NAGAYA Noritoshi 永谷憲歳

Researcher Number	60372116
Affiliation (based on the past Project Information) *help	2008: 循環器病センター, 研究員 2006 – 2007: 国立循環器病センター研究所, 先進医学工学センター, 部長 2005 – 2007: 国立循環器病センター, 再生医療部, 部長 2004 – 2007: 国立循環器病センター研究所, 再生医療部, 部長 2005 – 2006: National Cardiovascular Center Research Institute, Department of Regenrative Medicine, Head, 再生医療部, 部長 2005 – 2006: 国立循環器病センター, 研究所, 部長 2004: 国立循環器病センター研究所, 再生医療部, 室長
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine Except Principal Investigator Circulatory organs internal medicine / Experimental pathology / General surgery / Respiratory organ internal medicine
Keywords	Principal Investigator 薬理学 / 発現抑制 / 循環器・高血圧 / シグナル伝達 / 核酸 / サイトカイン / 炎症 / 肺血管透過性亢進 / アポトーシス / アドレノメデュリン / 急性肺障害 … More Except Principal Investigator … More Ghrelin / disease-model animal / lvmphangiogenesis / angiogenesis / mouse / chimera / vasodilatineg peptide / receptor activity-modifying Protein / Adrenomedullin / 血管新生 / 脈管形成 / 疾患モデル動物 / キメラマウス / 血管作動性ペプチド / 受容体修飾因子 / アドレノメデュリン / Hypertrophy / Fibrosis / Cardiac Remodeling / Myocardial Infarction / 拡張型心筋症 / 心不全 / 心臓リモデリング / 心筋梗塞 / グレリン / FACS / 抗MHC class I抗体 / 骨髄移植 / 正常免疫能マウス / 血清補体活性 / 免疫不全マウス / ブタ骨髄細胞 / 骨髄内骨髄移植 / 間葉系幹細胞 / 免疫寛容 / 異種移植 / 右室肥大 / 肺血管リモデリング / 慢性低酸素 / 慢性閉塞性肺疾患 / 肺高血圧症 / エラスターゼ / 低酸素 / 抗炎症効果 / 摂食亢進作用 / グレリン(ghrelin) / ラット / 生体内拍動心臓 / 細胞内Ca^<2+>放出機構 / リアノジン / βアドレナリン受容体刺激 / ミオシン間距離 / 心筋収縮タンパク / 心肥大 / 高血圧ラット / ナノテクノロジー / 小角散乱 / X線回折法 / 放射光 / クロスブリッジ動態 / 心筋収縮タンパク質 Less

siRNAを用いた肺高血圧治療法の開発Principal Investigator
- Principal Investigator
  
  永谷憲歳
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Production and characterization of Adrenomedullin (-/-)<->(+/+) and RAMP2(-/-)<-> (+/+) chimeric mice
- Principal Investigator
  
  SAKURAI Takayuhi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shinshu University
肺高血圧ラットモデルにおけるグレリンの抗炎症作用に関する検討
- Principal Investigator
  
  木村弘
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nara Medical University
循環調節ペプチドを用いた新たな難治性肺疾患治療の開発Principal Investigator
- Principal Investigator
  
  永谷憲歳
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
異種移植における免疫寛容導入を目的とした間葉系幹細胞・骨髄同時移植モデルの確立
- Principal Investigator
  
  江口寛, 川野淳
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Osaka University
放射光を用いた心筋クロスブリッジ動態の実時間解析法の確立と臨床応用
- Principal Investigator
  
  白井幹康
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Hiroshima International University
Ghrelin suppresses cardiac sympathetic activity and attenuates early left ventricular remodeling in rats with myocardial infarction
- Principal Investigator
  
  KISHIMOTO Ichiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute

All 2008 2007 2006 2005 2004 Other

All Journal Article

[Journal Article] Single Injection of a Sustained-release Prostacyclin Analog Improves Pulmonary Hypertension in Rats.2008
- Author(s)
  Obata H, Sakai Y, Ohnishi S, Takeshita S, Mori H, Kodama M, Kangawa K, Aizawa Y, Nagaya N.
- Journal Title
  
  Am J Respir Crit Care Med. 177
  
  Pages: 195-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590927
[Journal Article] Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats.2007
- Author(s)
  Itoh T, Obata H, Murakami S, Hamada K, Kangawa K, Kimura H, Nagaya N.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol. 293
  
  Pages: 446-452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590927
[Journal Article] CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis. Biochem Biophys Res Commun.2007
- Author(s)
  Obata H, Yanagawa B, Tanaka K, Ohnishi S, Kataoka M, Miyahara Y, Ishibashi-Ueda H, Kodama M, Aizawa Y, Kangawa K, Nagaya N
- Journal Title
  
  Biochem Biophys Res Commun. 27・356
  
  Pages: 60-66
- Data Source
  KAKENHI-PROJECT-17659250
[Journal Article] Effect of Hypoxia on Gene Expression of Bone Marrow-derived Mesenchymal Stem Cells and Mononuclear Cells.2007
- Author(s)
  Ohnishi S, Yasuda T, Kitamura S, Nagaya N
- Journal Title
  
  Stem Cells (in press)
- Data Source
  KAKENHI-PROJECT-17659250
[Journal Article] A prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice.2006
- Author(s)
  Murakami S, Nagaya N, Itoh T, Kataoka M, Iwase T, Horio T, Miyahara Y, Sakai Y, Kangawa K, Kimura H.
- Journal Title
  
  Am J Physiol Lung Cell Mol Physiol 290・1
- Data Source
  KAKENHI-PROJECT-17659250
[Journal Article] Treatment of cachexia with ghrelin in patients with COPD.2005
- Author(s)
  Nagaya N, Itoh T, Murakami S, Oya H, Uematsu M, Miyatake K, Kangawa K.
- Journal Title
  
  Chest 128
  
  Pages: 1187-1193
- Data Source
  KAKENHI-PROJECT-17659250
[Journal Article] Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension.2004
- Author(s)
  Nagaya, N.
- Journal Title
  
  Circulation 109
  
  Pages: 351-356
- Data Source
  KAKENHI-PROJECT-16659210
[Journal Article] Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats
- Author(s)
  Takefumi Itoh, Noritoshi Nagaya, Shinsuke Murakami, Kaoru Hamada, Kenji Kangawa, Hiroshi Kimura
- Journal Title
  
  Am J Respir Crit Care Med (Revise)
- Data Source
  KAKENHI-PROJECT-17659250

1. KANGAWA Kenji (00112417)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. 江口寛 (20379267)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 佐田正晴 (20162399)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KISHIMOTO Ichiro (80312221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SAKURAI Takayuhi (80317825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHINDO Takayuki (90345215)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SATO Masahiro (30287099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHIMOSAWA Tatsuo (90231365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 白井幹康 (70162758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 菅弘之 (90014117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 西浦直亀 (70132933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 木村弘 (20195374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 濱田薫 (80228535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 玉置伸二 (30347546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 須崎康恵 (30382302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 米田和之 (70405380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 盛英三 (90146598)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 川野淳 (60133138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 大西俊介 (10443475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 山原研一 (50450888)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ピアーソンジェームズ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAGAYA Noritoshi 永谷 憲歳

Research Projects

Research Products

Co-Researchers

siRNAを用いた肺高血圧治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Production and characterization of Adrenomedullin (-/-)<->(+/+) and RAMP2(-/-)<-> (+/+) chimeric mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肺高血圧ラットモデルにおけるグレリンの抗炎症作用に関する検討

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

循環調節ペプチドを用いた新たな難治性肺疾患治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

異種移植における免疫寛容導入を目的とした間葉系幹細胞・骨髄同時移植モデルの確立

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

放射光を用いた心筋クロスブリッジ動態の実時間解析法の確立と臨床応用

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ghrelin suppresses cardiac sympathetic activity and attenuates early left ventricular remodeling in rats with myocardial infarction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Single Injection of a Sustained-release Prostacyclin Analog Improves Pulmonary Hypertension in Rats.2008

Author(s)

Journal Title

Data Source

[Journal Article] Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats.2007

Author(s)

Journal Title

Data Source

[Journal Article] CNP infusion attenuates cardiac dysfunction and inflammation in myocarditis. Biochem Biophys Res Commun.2007

Author(s)

Journal Title

Data Source

[Journal Article] Effect of Hypoxia on Gene Expression of Bone Marrow-derived Mesenchymal Stem Cells and Mononuclear Cells.2007

Author(s)

Journal Title

Data Source

[Journal Article] A prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice.2006

Author(s)

Journal Title

Data Source

[Journal Article] Treatment of cachexia with ghrelin in patients with COPD.2005

Author(s)

Journal Title

Data Source

[Journal Article] Effects of adrenomedullin inhalation on hemodynamics and exercise capacity in patients with idiopathic pulmonary arterial hypertension.2004

Author(s)

Journal Title

Data Source

[Journal Article] Adrenomedullin ameliorates lipopolysaccharide-induced acute lung injury in rats

Author(s)

Journal Title

Data Source

NAGAYA Noritoshi 永谷憲歳