Ujiie Hideyuki 氏家英之

… Alternative Names

UJIIE HIDEYUKI 氏家英之

UJIIE Hideyuki 氏家英之

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Researcher Number	60374435
Other IDs
Affiliation (Current)	2025: 北海道大学, 医学研究院, 教授
Affiliation (based on the past Project Information) *help	2025: 北海道大学, 医学研究院, 教授 2020 – 2023: 北海道大学, 医学研究院, 教授 2016 – 2021: 北海道大学, 大学病院, 講師 2017: 北海道大学, 大学病院, 助教 2015: 北海道大学, 大学病院, 助教 2012 – 2013: 北海道大学, 北海道大学病院, 助教 2011 – 2013: 北海道大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related / Medium-sized Section 53:Organ-based internal medicine and related fields Except Principal Investigator Basic Section 53050:Dermatology-related / Dermatology
Keywords	Principal Investigator 水疱性類天疱瘡 / 制御性T細胞 / 17型コラーゲン / 免疫寛容 / BP180 / ノックアウトマウス / サイトカイン / 疾患モデル動物 / 自己免疫疾患 / Age-associated B cell … More / 水疱症 / 免疫チェックポイント阻害薬 / DPP-4阻害薬 / 7型コラーゲン / 類天疱瘡 / 加齢 / 尋常性天疱瘡 / mTEC / 胸腺 / トランスジェニックマウス / 皮膚炎 / 自己免疫性水疱症 / T細胞受容体 / アクティブマウスモデル / T細胞株 / BP230 / IPEX症候群 / Scurfyマウス / Th1/Th2 / ヒト化マウス … More Except Principal Investigator 自己免疫 / 皮膚病態学 / 17型コラーゲン / 水疱性類天疱瘡 / 自己免疫疾患 / 自己抗体 / 自己免疫性水疱症 / 皮膚癌 / 既存薬 / 核酸医薬 / 治療濃度 / 細胞周期 / 細胞死 / 薬剤スクリーニング / 血管肉腫 / CD203c / 好塩基球 / IgE / C1q / 抗原枯渇 / 病原性抗体 / NC16A / Fc結合タンパク / 補体 / 水疱症 / 7型コラーゲン / 後天性表皮水疱症 / Th17 / Th17細胞 / 経皮免疫 / 尋常性乾癬 / 皮膚病態斈 / 免疫寛容 / コラーゲン / 酵素 / 細胞・組織 / タンパク質 / 生体分子 / 皮膚病理学 / 補体活性化 / 抗体サブクラス / IgG1/IgG4 / 疾患モデル動物 / ヒト化マウス Less

HLAと薬剤に着目した自己免疫性水疱症の発症機序の解明Principal Investigator
- Principal Investigator
  
  氏家英之
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hokkaido University
Development of a novel therapeutic strategy for angiosarcoma through drug screening
- Principal Investigator
  
  中村秀樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hokkaido University
水疱性類天疱瘡におけるIgE自己抗体特異的皮膚炎症増幅機構の解明
- Principal Investigator
  
  泉健太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hokkaido University
Elucidation of the mechanism of the breakdown of cutaneous immune tolerance focusing on agingPrincipal Investigator
- Principal Investigator
  
  Ujiie Hideyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hokkaido University
エピトープスプレディング現象に着目した水疱性類天疱瘡の病態解明
- Principal Investigator
  
  西江渉
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hokkaido University
Elucidation of the mechanism of breakdown of cutaneous immune tolerance using an innovative mouse modelPrincipal Investigator
- Principal Investigator
  
  Ujiie Hideyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Hokkaido University
The impact of complement in blistering formation of pemphigoid
- Principal Investigator
  
  Iwata Hiroaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Hokkaido University
Generation of bullous pemphigoid antigen specific T cell clonesPrincipal Investigator
- Principal Investigator
  
  UJIIE Hideyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University
Novel bullous pemphigoid models induced by breaking tolerance to autoantigens.
- Principal Investigator
  
  Nishie Wataru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University
The role of Th17 cells in the pathogenesis of autoimmune blistering disease
- Principal Investigator
  
  Iwata Hiroaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University
Analysis of regulatory T cells and application for cell therapy in bullous pemphigoidPrincipal Investigator
- Principal Investigator
  
  Ujiie Hideyuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University
Production of a novel blistering disease model by regulating expression of collagen XVII
- Principal Investigator
  
  Nishie Wataru
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University
Development of novel treatment targeting complement for bullous pemphigoid
- Principal Investigator
  
  SHIBAKI Akihiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University
Analysis of the role of T cell subsets and the development of novel treatment for bullous pemphigoidPrincipal Investigator
- Principal Investigator
  
  UJIIE Hideyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 Other

All Journal Article Presentation Book

[Book] BIO Clinica 2022年8月臨時増刊号2022
- Author(s)
  氏家英之ほか　（編者：本田哲也）
- Total Pages
  92
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-21H02938
[Book] WHAT'S NEW in 皮膚科学 2022-20232022
- Author(s)
  氏家英之ほか　（編者：常深祐一郎、鶴田大輔）
- Total Pages
  178
- Publisher
  メディカルレビュー社
- ISBN
  9784779226199
- Data Source
  KAKENHI-PROJECT-21H02938
[Journal Article] Clinical-histopathological features and cancer gene analysis of cutaneous epithelioid angiosarcoma: A report of 4 cases2024
- Author(s)
  Tokuchi Keiko、Yanagi Teruki、Kurosawa Suguru、Kitamura Shinya、Maeda Takuya、Hsu Che Yuan、Miyamoto Kodai、Nishihara Hiroshi、Ujiie Hideyuki
- Journal Title
  
  JAAD Case Reports
  
  Volume: 46 Pages: 45-48
- DOI
  10.1016/j.jdcr.2023.11.039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07757
[Journal Article] Association of Genetic Variants of HLA-DQA1 with Bullous Pemphigoid Induced by Dipeptidyl Peptidase-4 Inhibitors2023
- Author(s)
  Ozeki Takeshi、Muramatsu Ken、Yoshimoto Norihiro、Ujiie Inkin、Izumi Kentaro、Iwata Hiroaki、Mushiroda Taisei、Ujiie Hideyuki
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 143 Issue: 11 Pages: 2219-2225.e5
- DOI
  10.1016/j.jid.2023.04.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02938
[Journal Article] Eribulin inhibits growth of cutaneous squamous cell carcinoma cell lines and a novel patient-derived xenograft2023
- Author(s)
  Hsu Che-Yuan、Yanagi Teruki、Maeda Takuya、Nishihara Hiroshi、Miyamoto Kodai、Kitamura Shinya、Tokuchi Keiko、Ujiie Hideyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 8650-8650
- DOI
  10.1038/s41598-023-35811-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08397, KAKENHI-PROJECT-23K07757
[Journal Article] Detection of a natural antibody targeting the shed ectodomain of BP180 in mice2023
- Author(s)
  Mai Yosuke、Izumi Kentaro、Mai Shoko、Nishie Wataru、Ujiie Hideyuki
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 112 Issue: 1 Pages: 15-22
- DOI
  10.1016/j.jdermsci.2023.07.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08421
[Journal Article] Native Autoantigen Complex Detects Pemphigoid Autoantibodies2023
- Author(s)
  Mai Shoko、Izumi Kentaro、Mai Yosuke、Natsuga Ken、Ishii Norito、Sawamura Daisuke、Schauer Franziska、Kiritsi Dimitra、Nishie Wataru、Ujiie Hideyuki
- Journal Title
  
  JID Innovations
  
  Volume: 3 Issue: 3 Pages: 100193-100193
- DOI
  10.1016/j.xjidi.2023.100193
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17334, KAKENHI-PROJECT-22K08419, KAKENHI-PROJECT-21K08316, KAKENHI-PROJECT-21H02938
[Journal Article] Eribulin for patients with metastatic extramammary Paget disease: Study protocol for a single‐arm phase II trial2023
- Author(s)
  Maeda Takuya、Yanagi Teruki、Tokuchi Keiko、Funakoshi Takeru、Horie Nao、Isoe Toshiyuki、Ito Yoichi M.、Sato Norihiro、Ujiie Hideyuki
- Journal Title
  
  Experimental Dermatology
  
  Volume: 33 Issue: 1
- DOI
  10.1111/exd.14993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07757
[Journal Article] A case of bullous pemphigoid developing under treatment with benralizumab for bronchial asthma2023
- Author(s)
  Tanaka Arisa、Fujimura Yu、Fuke Satoshi、Izumi Kentaro、Ujiie Hideyuki
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 50 Issue: 9 Pages: 1199-1202
- DOI
  10.1111/1346-8138.16811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02938
[Journal Article] Two cases of Hallopeau-type pemphigus vegetans with anti-desmoglein 1 and anti-desmocollin 3 antibodies without mucosal involvement.2023
- Author(s)
  Kawamura T, Muramatsu K, Orita A, Mai Y, Sugai T, Haga N, Fujimura Y, Miyauchi T, Izumi K, Koga H, Ishii N, Ujiie H.
- Journal Title
  
  J Eur Acad Dermatol Venereol
  
  Volume: 37 Issue: 4
- DOI
  10.1111/jdv.18704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08419, KAKENHI-PROJECT-21H02938
[Journal Article] Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases2022
- Author(s)
  Ujiie Hideyuki, Rosmarin David, Schon Michael P., et al.
- Journal Title
  
  Frontiers in Medicine
  
  Volume: 9
- DOI
  10.3389/fmed.2022.875492
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02938
[Journal Article] What's new in the pathogeneses and triggering factors of bullous pemphigoid2022
- Author(s)
  Ujiie Hideyuki
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 50 Issue: 2 Pages: 140-149
- DOI
  10.1111/1346-8138.16654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02938, KAKENHI-PROJECT-20K21590
[Journal Article] Super‐resolution imaging detects BP180 autoantigen in immunoglobulin M pemphigoid2021
- Author(s)
  Hirano Yoko、Iwata Hiroaki、Tsujuwaki Masumi、Mai Shoko、Mai Yosuke、Imafuku Keisuke、Izumi Kentaro、Koga Hiroshi、Ujiie Hideyuki
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 49 Issue: 3 Pages: 374-378
- DOI
  10.1111/1346-8138.16260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08786
[Journal Article] Prevalence of infectious diseases in patients with autoimmune blistering diseases2020
- Author(s)
  Ujiie Inkin、Ujiie Hideyuki、Yoshimoto Norihiro、Iwata Hiroaki、Shimizu Hiroshi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 47 Issue: 4 Pages: 378-384
- DOI
  10.1111/1346-8138.15244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04238
[Journal Article] Immune Reaction to Type XVII Collagen Induces Intramolecular and Intermolecular Epitope Spreading in Experimental Bullous Pemphigoid Models2019
- Author(s)
  Ujiie Hideyuki、Yoshimoto Norihiro、Natsuga Ken、Muramatsu Ken、Iwata Hiroaki、Nishie Wataru、Shimizu Hiroshi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 10 Pages: 1-10
- DOI
  10.3389/fimmu.2019.01410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04238
[Journal Article] Fc-binding proteins enhance autoantibody-induced BP180 depletion in pemphigoid2019
- Author(s)
  Iwata H, Kamaguchi M, Ujiie H, Ujiie I, Natsuga K, Nishie W, ShimizuH:
- Journal Title
  
  J Pathol
  
  Volume: 247 Issue: 3 Pages: 371-380
- DOI
  10.1002/path.5196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10141, KAKENHI-PROJECT-17K16317
[Journal Article] Clinical and immunological features of pemphigus relapse2019
- Author(s)
  Ujiie I.、Ujiie H.、Iwata H.、Shimizu H.
- Journal Title
  
  British Journal of Dermatology
  
  Volume: 180 Issue: 6 Pages: 1498-1505
- DOI
  10.1111/bjd.17591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04238
[Journal Article] Case of autoimmune intraepidermal and subepidermal blistering disease in which autoantibodies to desmoglein 1 and BP230 coexist2019
- Author(s)
  Sugai Tatsuro、Ujiie Hideyuki、Nakamura Hiroyuki、Kikuchi Kazuhiro、Iwata Hiroaki、Shimizu Hiroshi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 印刷中 Issue: 6
- DOI
  10.1111/1346-8138.14734
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04238
[Journal Article] High Expression of Collagen XVII Compensates for Its Depletion Induced by Pemphigoid IgG in the Oral Mucosa.2018
- Author(s)
  Kamaguchi M, Iwata H, Ujiie H, Natsuga K, Nishie W, Kitagawa Y, Shimizu H.
- Journal Title
  
  J Invest Dermatol.
  
  Volume: - Issue: 8 Pages: 1707-1715
- DOI
  10.1016/j.jid.2018.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10141, KAKENHI-PROJECT-17K16317
[Journal Article] Oral mucosa is a useful substrate for detecting autoantibodies of mucous membrane pemphigoid.2018
- Author(s)
  Kamaguchi M, Iwata H, Ujiie H, Izumi K, Natsuga K, Nishie W, Asaka T, Kitagawa Y, Shimizu H.
- Journal Title
  
  Br J Dermatol.
  
  Volume: 178 Issue: 2 Pages: e119-e121
- DOI
  10.1111/bjd.15925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10141, KAKENHI-PROJECT-17K16317
[Journal Article] The direct binding of collagen XVII and collagen IV is disrupted by pemphigoid autoantibodies2018
- Author(s)
  Kamaguchi Mayumi、Iwata Hiroaki、Nishie Wataru、Toyonaga Ellen、Ujiie Hideyuki、Natsuga Ken、Kitagawa Yoshimasa、Shimizu Hiroshi
- Journal Title
  
  Laboratory Investigation
  
  Volume: 99 Issue: 1 Pages: 48-57
- DOI
  10.1038/s41374-018-0113-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10120, KAKENHI-PROJECT-16K10141, KAKENHI-PROJECT-17K16317
[Journal Article] Characteristics of IgG subclasses and complement deposition in BP230-type bullous pemphigoid2018
- Author(s)
  Zheng M.、Ujiie H.、Iwata H.、Muramatsu K.、Yoshimoto N.、Ito T.、Ujiie I.、Shimizu S.、Sato-Matsumura K.C.、Shimizu H.
- Journal Title
  
  Journal of the European Academy of Dermatology and Venereology
  
  Volume: 33 Issue: 3 Pages: 595-600
- DOI
  10.1111/jdv.15325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04238
[Journal Article] Detection of anti-BP180 NC16A autoantibodies after the onset of dipeptidyl peptidase-IV inhibitor-associated bullous pemphigoid: a report of three patients2018
- Author(s)
  Mai Y.、Nishie W.、Izumi K.、Yoshimoto N.、Morita Y.、Watanabe M.、Toyonaga E.、Ujiie H.、Iwata H.、Fujita Y.、Nomura T.、Sato-Matsumura K.C.、Shimizu S.、Shimizu H.
- Journal Title
  
  British Journal of Dermatology
  
  Volume: 179 Issue: 3 Pages: 790-791
- DOI
  10.1111/bjd.16656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19531, KAKENHI-PROJECT-16H05365
[Journal Article] Bullous pemphigoid with the deposition of IgG2 but not IgG1, IgG3 nor IgG4 autoantibodies at the basement membrane zone2018
- Author(s)
  Yoshimoto N.、Ujiie H.、Zheng M.、Iwata H.、Kosumi H.、Hata H.、Shimizu H.
- Journal Title
  
  Journal of the European Academy of Dermatology and Venereology
  
  Volume: 32 Issue: 9
- DOI
  10.1111/jdv.14920
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04238
[Journal Article] C-Terminal Processing of Collagen XVII Induces Neoepitopes for Linear IgA Dermatosis Autoantibodies2017
- Author(s)
  Toyonaga Ellen、Nishie Wataru、Izumi Kentaro、Natsuga Ken、Ujiie Hideyuki、Iwata Hiroaki、Yamagami Jun、Hirako Yoshiaki、Sawamura Daisuke、Fujimoto Wataru、Shimizu Hiroshi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 137 Issue: 12 Pages: 2552-2559
- DOI
  10.1016/j.jid.2017.07.831
- NAID
  120006540048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10207, KAKENHI-PROJECT-17K16317, KAKENHI-PROJECT-26293254, KAKENHI-PROJECT-16H05365, KAKENHI-PROJECT-16K15539, KAKENHI-PROJECT-16K15541, KAKENHI-PROJECT-15KK0289
[Journal Article] Detection of mucous membrane pemphigoid autoantibodies by full-length BP180 enzyme-linked immunosorbent assay2017
- Author(s)
  Izumi Kentaro、Nishie Wataru、Mai Yosuke、Ujiie Hideyuki、Iwata Hiroaki、Natsuga Ken、Shimizu Hiroshi
- Journal Title
  
  J Dermatol Sci
  
  Volume: 88 Issue: 2 Pages: 247-248
- DOI
  10.1016/j.jdermsci.2017.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16317, KAKENHI-PROJECT-17K16318, KAKENHI-PROJECT-16H05365, KAKENHI-PROJECT-16K15539, KAKENHI-PROJECT-15KK0289
[Journal Article] Autoantibody profile differentiates between inflammatory and noninflammatory bullous pemphigoid.2016
- Author(s)
  Izumi K, Nishie W, Mai Y, Wada M, Natsuga K, Ujiie H, Iwata H, Yamagami J, Shimizu H
- Journal Title
  
  J Invest Dermatol
  
  Volume: 136 Issue: 11 Pages: 2201-2210
- DOI
  10.1016/j.jid.2016.06.622
- NAID
  120006360054
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05365, KAKENHI-PROJECT-15K19668, KAKENHI-PROJECT-16K15539
[Journal Article] In vivo analysis of IgE autoantibodies in bullous pemphigoid: A study of 100 cases.2015
- Author(s)
  Moriuchi R, Nishie W, Ujiie H, Natsuga K, Shimizu H.
- Journal Title
  
  J Dermatol Sci
  
  Volume: 78 Issue: 1 Pages: 21-25
- DOI
  10.1016/j.jdermsci.2015.01.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390274, KAKENHI-PROJECT-26670516, KAKENHI-PROJECT-15K19668
[Journal Article] Context-Dependent Regulation of Collagen XVII Ectodomain Shedding in Skin.2015
- Author(s)
  Nishie W, Natsuga K, Iwata H, Izumi K, Ujiie H, Toyonaga E, Hata H, Nakamura H, Shimizu H.
- Journal Title
  
  Am J Pathol
  
  Volume: in press Issue: 5 Pages: 1361-71
- DOI
  10.1016/j.ajpath.2015.01.012
- NAID
  120005752843
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390274, KAKENHI-PROJECT-25461661, KAKENHI-PROJECT-26670516, KAKENHI-PROJECT-15K19668
[Journal Article] Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and independent manner2012
- Author(s)
  Natsuga K, Nishie W, Shinkuma S, Ujiie H, Nishimura M, Sawamura D, Shimizu H
- Journal Title
  
  J Immunol
  
  Volume: (in press) Issue: 11 Pages: 5792-5799
- DOI
  10.4049/jimmunol.1003402
- NAID
  10031131103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689021, KAKENHI-PROJECT-23591635, KAKENHI-PROJECT-23659538, KAKENHI-PROJECT-23791242, KAKENHI-PROJECT-24390152, KAKENHI-PROJECT-24659514
[Journal Article] Evidence for pathogenicity of autoreactive T cells in autoimmune bullous diseases shown by animal disease models2012
- Author(s)
  Ujiie H, Shimizu H
- Journal Title
  
  Experimental Dermatology
  
  Volume: 21 Issue: 12 Pages: 901-5
- DOI
  10.1111/exd.12011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591635, KAKENHI-PROJECT-23791242
[Journal Article] Noncollagenous 16A domain of type XVII collagen-reactive CD4(+) T cells play a pivotal role in the development of active disease in experimental bullous pemphigoid model2012
- Author(s)
  Ujiie H, Shibaki A, Nishie W, Shinkuma S, Moriuchi R, Qiao H, Shimizu H
- Journal Title
  
  Clin Immunol
  
  Volume: 142 Issue: 2 Pages: 167-175
- DOI
  10.1016/j.clim.2011.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689021, KAKENHI-PROJECT-21249063, KAKENHI-PROJECT-23591635, KAKENHI-PROJECT-23659538, KAKENHI-PROJECT-23791242
[Journal Article] Mucous membrane pemphigoid with generalized blisters : IgA and IgG autoantibodies target both laminin-332 and type XVII collagen2012
- Author(s)
  Hayashi I, Shinkuma S, Shimizu S, Natsuga K, Ujiie H, Yasui C, Tsuchiya K, Nishie W, Shimizu H
- Journal Title
  
  Br J Dermatol
  
  Volume: (in press) Issue: 5 Pages: 1116-1120
- DOI
  10.1111/j.1365-2133.2011.10776.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20689021, KAKENHI-PROJECT-23659538, KAKENHI-PROJECT-23791242
[Presentation] Conformational epitope mapping of autoantibodies against BP180 in dipeptidyl peptidase-4 inhibitors-associated bullous pemphigoid2023
- Author(s)
  Shoko Mai, Kentaro Izumi, Yosuke Mai, Ken Natsuga, Wataru Nishie, and Hideyuki Ujiie
- Organizer
  International Societies for Investigative Dermatology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] 多彩な臨床像を呈する自己免疫性水疱症2023
- Author(s)
  氏家英之
- Organizer
  第122回日本皮膚科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] 類天疱瘡におけるステロイド全身療法の再考2023
- Author(s)
  氏家英之
- Organizer
  第87回日本皮膚科学会東京支部学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] 抗BP230抗体単独陽性の類天疱瘡2023
- Author(s)
  氏家英之
- Organizer
  日本皮膚科学会東北六県合同地方会学術大会第402回例会
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] Type XVII collagen-specific CD4+ T cell clones induce bullous pemphigoid in mice by producing IL-52023
- Author(s)
  Norihiro Yoshimoto, Ken Muramatsu, Takamasa Ito, Zheng Miao, Kentaro Izumi, Ken Natsuga, Hiroaki Iwata, Yoshinori Hasegawa, Hiroshi Shimizu, Hideyuki Ujiie
- Organizer
  International Societies for Investigative Dermatology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] NUDT15 variants among Japanese patients with autoimmune blistering diseases: a single-center retrospective observational study2023
- Author(s)
  Sho Katayama, Kentaro Izumi, Norihiro Yoshimoto, Inkin Ujiie, Hideyuki Ujiie
- Organizer
  International Societies for Investigative Dermatology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] 自己免疫性水疱症～知っておきたい基本知識と最新知見～2023
- Author(s)
  氏家　英之
- Organizer
  第152回日本皮膚科学会広島地方会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] Conformational epitope mapping of autoantibodies against BP180 in dipeptidyl peptidase-4 inhibitors-associated bullous pemphigoid2023
- Author(s)
  Mai S, Izumi K, Mai Y, Natsuga K, Nishie W, Ujiie H
- Organizer
  International Societies for Investigative Dermatology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08421
[Presentation] Basophil activation and low levels of circulating basophils correlate with clinical severity in bullous pemphigoid2023
- Author(s)
  Takuya Kawamura, Kentaro Izumi, Haruhisa Watanabe, Yosuke Mai, Shoko Mai, Sho Katayama, Norihiro Yoshimoto, Inkin Ujiie, Hideyuki Ujiie
- Organizer
  International Societies for Investigative Dermatology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] Th2 immune response in bullous pemphigoid.2023
- Author(s)
  Hideyuki Ujiie
- Organizer
  ISID 2023 Tokyo Satellite Meeting. International Symposium on Autoimmunity Targeting the Skin; Pemphigus, Pemphigoid, and Beyond
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] Bullous pemphigoid (BP) and premonitory BP2023
- Author(s)
  Hideyuki Ujiie
- Organizer
  25th World Congress of Dermatology Singapore 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] Type2炎症から読み解くアトピー性皮膚炎と類天疱瘡の病態と治療戦略2023
- Author(s)
  氏家英之
- Organizer
  第158回日本皮膚科学会徳島地方会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] NUDT15 variants among Japanese patients with autoimmune blistering diseases: a single-center retrospective observational study2023
- Author(s)
  Katayama S, Izumi K, Yoshimoto N, Ujiie I, Ujiie H
- Organizer
  International Societies for Investigative Dermatology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08421
[Presentation] Basophil activation and low levels of circulating basophils correlate with clinical severity in bullous pemphigoid2023
- Author(s)
  Kawamura T, Izumi K, Watanabe H, Mai Y, Mai S, Katayama S, Yoshimoto N, Ujie I, Ujiie H
- Organizer
  International Societies for Investigative Dermatology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08421
[Presentation] Aged mice produce IgM autoantibodies against the basement membrane zone2023
- Author(s)
  Chihiro Shiiya, Ken Muramatsu, Norihiro Yoshimoto, Sho Katayama, Takuya Kawamura, Shoko Mai, Yosuke Mai, Hiroyuki Kitahata, Ken Natsuga, Hiroaki Iwata, Kentaro Izumi, Hideyuki Ujiie
- Organizer
  International Societies for Investigative Dermatology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] Basophil activation and low levels of circulating basophils correlate with clinical severity in bullous pemphigoid2023
- Author(s)
  Takuya Kawamura, Kentaro Izumi, Haruhisa Watanabe, Yosuke Mai, Shoko Mia, Sho Katayama, Norihiro Yoshimoto, Inkin Ujiie, Hideyuki Ujiie
- Organizer
  International Societies for Investigative Dermatology 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] Type XVII collagen-specific CD4+ T cell clones induce the phenotype of bullous pemphigoid in mice by producing Th2 cytokines2022
- Author(s)
  Norihiro Yoshimoto, Ken Muramatsu, Takamasa Ito, Zheng Miao, Ken Natsuga, Wataru Nishie, Hiroaki Iwata, Yoshinori Hasegawa, Hiroshi Shimizu, Hideyuki Ujiie
- Organizer
  The 47th Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] 中枢性免疫寛容に着目した自己免疫性水疱症の発症機序の解明2022
- Author(s)
  氏家　英之
- Organizer
  第121回日本皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-20K21590
[Presentation] 口腔粘膜疾患の診断と治療～粘膜類天疱瘡を中心に～2022
- Author(s)
  氏家　英之
- Organizer
  第60回日本口腔科学会北日本地方部会/第48回日本口腔外科学会北日本支部学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02938
[Presentation] Clarification of the mechanism of the breakdown of self-tolerance in bullous pemphigoid2019
- Author(s)
  Ujiie H
- Organizer
  The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-17H04238
[Presentation] New insights into bullous pemphigoid.2019
- Author(s)
  Ujiie H
- Organizer
  The 24th World Congress of Dermatology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04238
[Presentation] Mechanism of autoantibody production in bullous pemphigoid2019
- Author(s)
  Ujiie H
- Organizer
  Japan-Singapore International Skin Conference 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04238
[Presentation] 全長XVII型コラーゲンを抗原としたELISAによる粘膜類天疱瘡患者自己抗体の検出2015
- Author(s)
  泉　健太郎、西江　渉、夏賀　健、岩田浩明、氏家英之、清水　宏
- Organizer
  第37回水疱症研究会
- Place of Presentation
  コラッセ福島、福島市
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-24390274
[Presentation] Detection of pathological cleavage sites and neoepitopes on collagen XVII, a major autoantigen for bullous pemphigoid.2013
- Author(s)
  Nishie W, Ujiie H, Izumi K, Shimizu H
- Organizer
  International Investigative Dermatology 2013
- Place of Presentation
  Edinburgh International Conference Centre (Edinburgh, Scotland)
- Data Source
  KAKENHI-PROJECT-24390274
[Presentation] Bullous pemphigoid autoantibodies induce skin fragility in neonatal mice in a complement-independent manner2013
- Author(s)
  Sasaoka T, Ujiie H, Nishie W, Shibaki A, Nakamura H, Shimizu H
- Organizer
  The 6th International Investigative Dermatology 2013
- Place of Presentation
  イギリス
- Year and Date
  2013-05-09
- Data Source
  KAKENHI-PROJECT-23591635
[Presentation] Bullous pemphigoid autoantibodies induce skin fragility in neonatal mice in a complement-independent manner.2013
- Author(s)
  Sasaoka T, Ujiie H, Nishie W, Shibaki A, Nakamura H, Shimizu H
- Organizer
  The 6th International Investigative Dermatology 2013
- Place of Presentation
  Edinburgh International Conference Centre （イギリス）
- Data Source
  KAKENHI-PROJECT-23591635
[Presentation] Monoclonal human IgG1 and IgG4 against COL17 induce skin fragility in neonatal COL17-humanized mice in a complement-independent manner.2012
- Author(s)
  Sasaoka T, Ujiie H, Nishie W, Shibaki A, Shinkuma S, Tanabe M, Nakamura H, Shimizu H
- Organizer
  The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  ロワジールホテル＆スパタワー那覇（沖縄県）
- Data Source
  KAKENHI-PROJECT-23591635
[Presentation] Monoclonal human IgG1 and IgG4 against COL17 induce skin fragility in neonatal COL17-humanized mice in a complement-independent manner2012
- Author(s)
  Sasaoka T, Ujiie H, Nishie W, Shibaki A, Shinkuma S, Tanabe M, Nakamura H, Shimizu H
- Organizer
  The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  沖縄県
- Year and Date
  2012-12-07
- Data Source
  KAKENHI-PROJECT-23591635
[Presentation] 新規水疱性類天疱瘡アクティブマウスモデルにおけるCD4陽性T細胞サブセットの役割の解析2012
- Author(s)
  氏家英之,西江渉,新熊悟,清水宏
- Organizer
  第111回日本皮膚科学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-23791242
[Presentation] Neoepitopes on the modified amino-terminus of the shed ectodomain of collagen XVII2012
- Author(s)
  Nishie w, Ujiie H, et al.
- Organizer
  The 43rd Annual Meeting of the European Society for Dermatological Research
- Place of Presentation
  Venice Lido Congress Centre, Venice, Italy
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-24390274
[Presentation] 新規水疱性類天疱瘡アクティブマウスモデルにおけるCD4陽性T細胞サブセットの役割の解析2012
- Author(s)
  氏家英之、西江　渉、新熊　悟、清水　宏
- Organizer
  第111回日本皮膚科学会総会
- Place of Presentation
  国立京都国際会館（京都府）
- Data Source
  KAKENHI-PROJECT-23791242
[Presentation] Context-dependent tight regulation of collagen XVII ectodomain shedding in skin.
- Author(s)
  Nishie W, Natsuga K, Izumi K, Ujiie H, Hata H, Nakamura H, Shimizu H
- Organizer
  The 39th Annual Meeting of the Japanese Society of Invesitigative Dermatology
- Place of Presentation
  ホテル阪急エキスポパーク（吹田市）
- Year and Date
  2014-12-12 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-24390274

1. Nishie Wataru (20443955)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
2. Iwata Hiroaki (20397334)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
3. NATSUGA KEN (70645457)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
4. 泉健太郎 (50793668)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
5. 柳輝希 (50755973)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. SHIBAKI Akihiko (40291231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. SHIMIZU Hiroshi (00146672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
8. SHINKUMA SATORU (00613788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 鄭ビョウ (50833802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 中村秀樹 (60435956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 前田拓哉 (60979102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. MURAMATSU KEN

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TOYONAGA ellen

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NOMURA Toshifumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 西原広史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 平子善章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 石井文人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 古賀浩嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ujiie Hideyuki 氏家 英之

UJIIE HIDEYUKI 氏家 英之

UJIIE Hideyuki 氏家 英之

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Co-Researchers

HLAと薬剤に着目した自己免疫性水疱症の発症機序の解明Principal Investigator

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Elucidation of the mechanism of the breakdown of cutaneous immune tolerance focusing on agingPrincipal Investigator

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Elucidation of the mechanism of breakdown of cutaneous immune tolerance using an innovative mouse modelPrincipal Investigator

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Generation of bullous pemphigoid antigen specific T cell clonesPrincipal Investigator

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Analysis of regulatory T cells and application for cell therapy in bullous pemphigoidPrincipal Investigator

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Analysis of the role of T cell subsets and the development of novel treatment for bullous pemphigoidPrincipal Investigator

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Ujiie Hideyuki 氏家英之

UJIIE HIDEYUKI 氏家英之

UJIIE Hideyuki 氏家英之