Takahashi Hiroyuki 高橋博之

… Alternative Names

TAKAHASHI Hiroyuki 高橋博之

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Researcher Number	60377330
Other IDs
Affiliation (Current)	2025: 北里大学, 医療衛生学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 北里大学, 医療衛生学部, 教授 2017: 北里大学, 医療衛生学部, 教授 2010 – 2016: 北里大学, 医学部, 講師 2009: University of Toyama, 大学院・医学薬学研究部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related / Human pathology / General internal medicine (including Psychosomatic medicine)
Keywords	Principal Investigator 直腸癌 / 癌幹細胞ニッチ / β-カテニン / 簇出 / S100A4 / 進行大腸癌 / PD1 / PDL1 / 進行期直腸癌 / 癌免疫監視回避機構 … More / PD-L1 / NCRT / がん幹細胞 / βーカテニン / 化学・放射線療法 / 上皮間葉転換 / 化学放射線療法 / 癌幹細胞 / 胃腺腫 / 胃腺癌 / β‐カテニン / 病理組織診断 / 胃良悪性境界病変 / SV40トランスジェニックマウ / SV40トランスジェニックマウス / 抗癌剤 / 抗腫瘍効果 / 十全大補湯 Less

進行期直腸癌のS100A4依存性癌幹細胞ニッチ形成を標的とした新規治療戦略Principal Investigator
- Principal Investigator
  
  高橋博之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kitasato University
Association of nuclear beta-catenin and PD1/PDL1 expression with cancer stem niche in advanced rectal cancerPrincipal Investigator
- Principal Investigator
  
  Takahashi Hiroyuki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kitasato University
Possible role of nuclear b-catenin in resistance to preoperative chemoradiotherapy in locally advanced rectal cancerPrincipal Investigator
- Principal Investigator
  
  Takahashi Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
A combination of nuclear beta-catenin and atypical scores as useful diagnostic markers for borderline malignancy of gastric tumours.Principal Investigator
- Principal Investigator
  
  HIROYUKI Takahashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Kitasato University
oriental medicine has an effect on cancer : Molecular Pathological investigation about antitumor effect of Juzen-taiho-toPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hiroyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kitasato University
  University of Toyama

All 2023 2022 2017 2016 2015 2014 2013 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] A combination of stromal <scp>PD‐L1</scp> and tumoral nuclear β‐catenin expression as an indicator of colorectal carcinoma progression and resistance to chemoradiotherapy in locally advanced rectal carcinoma2022
- Author(s)
  Takahashi Hiroyuki、Watanabe Hirono、Hashimura Miki、Matsumoto Toshihide、Yokoi Ako、Nakagawa Mayu、Ishibashi Yu、Ito Takashi、Ohhigata Kensuke、Saegusa Makoto
- Journal Title
  
  The Journal of Pathology: Clinical Research
  
  Volume: 8 Issue: 5 Pages: 458-469
- DOI
  10.1002/cjp2.285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07397, KAKENHI-PROJECT-19K07421
[Journal Article] Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma.2017
- Author(s)
  Akiya M, Yamazaki M, Matsumoto T, Kawashima Y, Oguri Y, Kajita S, Kijima D, Chiba R, Yokoi A, Takahashi H, Kodera Y, Saegusa M.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 38 Pages: 63646-63664
- DOI
  10.18632/oncotarget.18882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15250, KAKENHI-PROJECT-17K19926, KAKENHI-PROJECT-17H02206, KAKENHI-PROJECT-15K08385
[Journal Article] Possible role of nuclear beta-catenin in resistance to preoperative chemoradiotherapy in locally advanced rectal cancer2017
- Author(s)
  Hiroyuki Takahashi, Kie Nakamura, Akane Usami, Tomoko Tsuruta, Miki Hashimura, Toshihide Matsumoto, Makoto Saegusa
- Journal Title
  
  Histopathology
  
  Volume: 印刷中 Issue: 2 Pages: 227-237
- DOI
  10.1111/his.13227
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08385
[Journal Article] A combination of nuclear β-catenin and atypical scores as useful diagnostic markers for borderline malignancy of gastric tumours.2014
- Author(s)
  Takahashi H, Ohkuma T, Tsuruta T, Saegusa M.
- Journal Title
  
  Histopathology
  
  Volume: 65 Issue: 6 Pages: 828-838
- DOI
  10.1111/his.12513
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790361
[Journal Article] Frequent β-catenin gene mutations in atypical polypoid adenomyoma of the uterus.2014
- Author(s)
  Takahashi, H., Yoshida, T., Matsumoto, T., Kameda, Y., Takano, Y., Tazo, Y., Inoue, H, Saegusa, M.
- Journal Title
  
  Hum Pathol
  
  Volume: 45 Issue: 1 Pages: 33-40
- DOI
  10.1016/j.humpath.2013.06.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590452, KAKENHI-PROJECT-24790361
[Journal Article] The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas2011
- Author(s)
  Zheng HC, Xia P, Xu XY, Takahashi H, Takano Y.
- Journal Title
  
  Hum Pathol
  
  Volume: 42 Pages: 424-33
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] Parafibromin expression is an independent prognostic factor for colorectal carcinomas2011
- Author(s)
  Zheng HC, Wei ZL, Xu XY, Nie XC, Yang X, Takahashi H, Takano Y.
- Journal Title
  
  Hum Pathol
  
  Volume: 42 Pages: 1089-102
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas2011
- Author(s)
  Zheng HC, Xia P, Xu XY, Takahashi H, Takano Y
- Journal Title
  
  Hum Pathol
  
  Volume: 42 Pages: 424-433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] Parafibromin expression is an independent prognostic factor for colorectal carcinomas2011
- Author(s)
  Zheng HC, Wei ZL, Xu XY, Nie XC, Yang X, Takahashi H, Takano Y
- Journal Title
  
  Hum Pathol
  
  Volume: 42 Pages: 1089-1102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis2011
- Author(s)
  Takahashi H, Wang JP, Zheng HC, Masuda S, Takano Y
- Journal Title
  
  Histol Histopathol
  
  Volume: 26 Pages: 663-671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis2011
- Author(s)
  Takahashi H, Wang JP, Zheng HC, Masuda S, Takano Y.
- Journal Title
  
  Histol Histopathol
  
  Volume: 26 Pages: 663-71
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] REG IV overexpression in an early stage of colorectal carcinogenesis : An immunohistochemical study.2010
- Author(s)
  Li XH, Zheng Y, Zheng HC, Takahashi H, Yang XH, Masuda S, Takano Y.
- Journal Title
  
  Histol Histopathol. 25
  
  Pages: 473-484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] The screening of viral risk factors in tongue and pharyngolaryngeal squamous carcinoma.2010
- Author(s)
  Zheng Y, Xia P, Zheng HC, Takahashi H, Masuda S, Takano Y.
- Journal Title
  
  Anticancer Res.
  
  Volume: 30 Pages: 1233-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas.2010
- Author(s)
  Zheng HC, Xu XY, Xing YN, Wei ZL, Takahashi, H, Masuda S, Takano Y.
- Journal Title
  
  Hum Pathol.
  
  Volume: 41 Pages: 724-736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] The role of Reg IV gene and its encoding product in gastric carcino genesis.2010
- Author(s)
  Zheng HC, Xu,XY, Yu M, Takahashi H, Masuda S, Takano Y.
- Journal Title
  
  Hum Pathol. 41
  
  Pages: 59-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes.2010
- Author(s)
  Zheng HC, Zheng YS, Xia P, Xu XY, Xing YN, Takahashi H, Guan YF, Takano Y.
- Journal Title
  
  Histol Histopathol.
  
  Volume: 25 Pages: 445-452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice.2009
- Author(s)
  Zheng HC, Nakamura T, Zheng Y, Nakanishi Y, Tabuchi Y, Uchiyama A, Takahashi H, Takano Y.
- Journal Title
  
  J Cancer Res Clin Oncol. 135
  
  Pages: 1521-1532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790624
[Journal Article] PTEN expression and mutation in colorectal carcinomas.2009
- Author(s)
  Li XH, Zheng HC, Takahashi H, Masuda S, Yang XH, Takano Y.
- Journal Title
  
  Oncol Rep. 22
  
  Pages: 757-764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790624
[Presentation] 進行大腸癌におけるS100A4発現の意義2023
- Author(s)
  原田　洋平、深川　菜央美、伊藤　隆、石橋　侑、橋村　美紀、小栗　康子、松本　俊英、高橋　博之、三枝　信
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K06967
[Presentation] 進行期直腸癌のb-カテニン/EMT誘導癌幹細胞化による化学・放射線療法の耐性機構の解析2017
- Author(s)
  高橋博之，橋村美紀，松本俊英，三枝信
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] The role of nuclear beta-catenin in resistance to preoperative chemoradiotherapy in rectal carcinoma2017
- Author(s)
  高橋博之、橋村美紀、松本俊英、三枝信
- Organizer
  第106回日本病理学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2017-04-27
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] 進行期直腸癌のβ-カテニン/EMT誘導癌幹細胞化による化学・放射線療法の耐性機構の解析2016
- Author(s)
  高橋博之、宇佐美茜、千葉理紗子、橋村美紀、三枝　信
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] 進行期直腸癌のb-カテニン/EMT誘導癌幹細胞化による化学・放射線療法の耐性機構の解析2015
- Author(s)
  高橋博之、中村貴恵、鶴田智子、三枝　信
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K08385
[Presentation] 子宮ポリープ状異型腺筋腫におけるβ-カテニン遺伝子異常の意義2013
- Author(s)
  高橋博之、梶田咲美乃、鶴田智子、　橋村美紀、　亀田陽一、高野康雄、三枝　信
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  北海道札幌市
- Data Source
  KAKENHI-PROJECT-24790361
[Presentation] The roles of ING5 during colorectal carcinogenesis and subsequent progression.2010
- Author(s)
  Zheng Huachuan, 高橋博之, 高野康雄
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京都)
- Data Source
  KAKENHI-PROJECT-21790624
[Presentation] 難治性黄疸の原因と考えられた総胆管peribiliary cystの一剖検例2010
- Author(s)
  高橋博之, 三輪重治, 野本一博, 林伸一, 常山幸一, 高野康雄
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21790624
[Presentation] 難治性黄疸の原因と考えられた総胆管peribiliary cystの一剖検例2010
- Author(s)
  高橋博之, 三輪重治, 野本一博, 林伸一, 常山幸一, 高野康雄
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京都)
- Data Source
  KAKENHI-PROJECT-21790624
[Presentation] 鋸歯状ポリープ-腺癌経路を示唆する癌と臨床病理学的事項の関係の検討2009
- Author(s)
  高橋博之, 中嶋隆彦, 藤本誠, 三輪重治, 野本一博, 林伸一, 常山幸一, 高野康雄
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790624
[Presentation] 自然発症肥満・糖尿病モデル(TSOD)マウスの肝病変NAFLD/NASHモデルとしての有用性.2009
- Author(s)
  常山幸一, 藤本誠, 野本一博, 高橋博之, 林伸一, 三輪重治, 高野康雄
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790624
[Presentation] Lipomatous myofibroblastomaの1例2009
- Author(s)
  野本一博, 中西ゆう子, 三輪重治, 高橋博之, 林伸一, 常山幸一, 高野康雄
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21790624
[Presentation] β-カテニンによる胃良悪性境界病変の新規病理組織診断ツールの確立
- Author(s)
  高橋博之、大熊拓也、三枝　信
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島県広島市
- Data Source
  KAKENHI-PROJECT-24790361

1. Saegusa Makoto (00265711)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
2. TAKANO Yasuo (60142022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
3. Hashimura Miki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. Nakamura Kie

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. Usami Akane

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 梶田咲美乃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 松本俊英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 吉田功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Hiroyuki 高橋 博之

TAKAHASHI Hiroyuki 高橋 博之

Research Projects

Research Products

Co-Researchers

進行期直腸癌のS100A4依存性癌幹細胞ニッチ形成を標的とした新規治療戦略Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Association of nuclear beta-catenin and PD1/PDL1 expression with cancer stem niche in advanced rectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Possible role of nuclear b-catenin in resistance to preoperative chemoradiotherapy in locally advanced rectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A combination of nuclear beta-catenin and atypical scores as useful diagnostic markers for borderline malignancy of gastric tumours.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

oriental medicine has an effect on cancer : Molecular Pathological investigation about antitumor effect of Juzen-taiho-toPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A combination of stromal <scp>PD‐L1</scp> and tumoral nuclear β‐catenin expression as an indicator of colorectal carcinoma progression and resistance to chemoradiotherapy in locally advanced rectal carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of LEFTY as a molecular marker for ovarian clear cell carcinoma.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible role of nuclear beta-catenin in resistance to preoperative chemoradiotherapy in locally advanced rectal cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A combination of nuclear β-catenin and atypical scores as useful diagnostic markers for borderline malignancy of gastric tumours.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frequent β-catenin gene mutations in atypical polypoid adenomyoma of the uterus.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas2011

Author(s)

Journal Title

Data Source

[Journal Article] Parafibromin expression is an independent prognostic factor for colorectal carcinomas2011

Author(s)

Journal Title

Data Source

[Journal Article] The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas2011

Author(s)

Journal Title

Data Source

[Journal Article] Parafibromin expression is an independent prognostic factor for colorectal carcinomas2011

Author(s)

Journal Title

Data Source

[Journal Article] Overexpression of GRP78 and GRP94 is involved in colorectal carcinogenesis2011

Author(s)

Journal Title

Data Source

Takahashi Hiroyuki 高橋博之

TAKAHASHI Hiroyuki 高橋博之