Tsuchimochi Hirotsugu 土持裕胤

… Alternative Names

TSUCHIMOCHI Hirotsugu 土持裕胤

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Researcher Number	60379948
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 室長
Affiliation (based on the past Project Information) *help	2015 – 2023: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2012 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 室長 2011: 独立行政法人国立循環器病研究センター, 心臓生理機能部, 室長 2008: 広島大, 助教 2007: Hiroshima University, 大学院・保健学研究科, 助教 … More 2006: 広島大学, 大学院・保健学研究科, 助手 2006: 広島大学, 大学院保健学研究科, 助手 2004 – 2005: Yamaguchi Univ., School of Med., Research Associate, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Sports science / Basic Section 59020:Sports sciences-related / Basic Section 59040:Nutrition science and health science-related / Sports science Except Principal Investigator Cardiovascular medicine / Basic Section 59020:Sports sciences-related / Basic Section 48020:Physiology-related / General physiology / Embryonic/Neonatal medicine / Obstetrics and gynecology / Neurophysiology and muscle physiology / Rehabilitation science/Welfare engineering
Keywords	Principal Investigator 運動 / 心臓 / aging / daily exercise / venous return / fetal gene program / exogenous nitric oxide / hypertrophy / cardiac elasticity / エピゲノム … More / メタボリックメモリー / 低出生体重 / 脂質異常症 / 生活習慣病 / 耐糖能異常 / オープンクロマチン領域解析 / タンパク質発現 / 遺伝子発現 / 心機能 / エピゲノム修飾 / 食餌療法 / 運動療法 / メタボリックシンドローム / dorsal root ganglia / exercise pressor reflex / muscle afferent / cardiovascular system / autonomic nervous system / Exercise pressor reflex / 血圧 / 交感神経 / 感覚神経 / 運動昇圧反射 / TRPV1 / blood pressure / cardiac function / muscle afferents / exercise / 自律神経活動 / 自立神経活動 / 循環 / 心臓自律神経 / 自律神経 / 心拍数 / 迷走神経 / アドレナリン / 副腎髄質 / 交感神経活動 / 動的運動 / 神経新生 / 運動ストレス / ストレス / うつ病 / 脳内モノアミン神経 / 神経変性 … More Except Principal Investigator 循環器・高血圧 / 糖尿病 / SOD / 低酸素症 / NO / 胎仔脳 / 間歇的低酸素 / 交感神経活動 / exercise hyperemia / microangiography / EDH / KCaチャネル / 超音波血流測定 / 易疲労性 / AICAR / AMPK / Goto-Kakizakiラット / コリンアセチルトランスフェラーゼ / 非神経性コリン作動系 / 血管内皮細胞 / アセチルコリン / Ca2+依存性K+チャネル / 運動トレーニング / 内皮依存性過分極 / 骨格筋収縮 / 微小血管造影 / 内皮依存性血管拡張 / ageing / vasodilators / aging / coronary vessels / coronary / nitric oxide / oxidative stress / inflammation / senescence / diabetes / coronary circulation / 放射光Ｘ線回折法 / 心筋拡張機能障害 / 放射光X線回折法 / 心筋収縮タンパク質 / 心臓拡張機能障害 / 肺高血圧症 / 肺交感神経 / マクロファージ / 肺高血圧 / 生理学 / cyclosporin-A / caspase-3 inhibitor / superior colliculus / in vivo optical recordings / fetus / hypoxia / caspase-3 / 保護機構 / 細胞内Caイオン / 光学的イメージング / in vivo光単的イメージング / チトクロームc / アポトーシス誘導因子 / 発達脳 / in vivo光学的イメージング / 上丘 / チトクロームC / シクロスポリン-A / カスパーゼー3 / oxygen / ischemia / delivery / superoxide dismutase / umbilical cord occlusion / fetal brain / asphyxia / 脳性麻痺 / 胎児脳 / zinc diethyldithiocarbamate / 酸化還元酵素 / 活性酸素 / 低酸素 / 脳血流 / 臍帯 / 脳幹 / 胎児 / 酸素 / 虚血 / 出産 / スーパーオキサイドディスミュテース / 臍帯結紮 / 仮死 / 微小循環 / 肺交感神経活動 / 肺循環 / 高血圧自然発症ラット / 延髄微小循環 / 心臓血管中枢 / 高血圧 / 橋渡し研究 / 冠循環 / 心臓リモデリング / 不整脈 / 慢性心不全 / グレリン / 心拍変動 / 心臓マイクロダイアリシス / 心臓自律神経活動 / 拡張型心筋症 / 心筋梗塞 / 心不全 / β受容体 / α受容体 / 血管収縮 / 交感神経刺激 / 骨レモデリング / 骨交感神経 / カルシウム代謝 / ホルモン / 交感神経系 / 骨血流量 / 骨リモデリング Less

How does daily exercise contribute to maintaining the elasticity of the heart?Principal Investigator
- Principal Investigator
  
  土持裕胤
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  National Cardiovascular Center Research Institute
Investigation of the endothelium-dependent mechanism by which diabetes causes fatigability of skeletal muscle
- Principal Investigator
  
  Sonobe Takashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Nippon Medical School
  National Cardiovascular Center Research Institute
Multi-layered elucidation of the effects of exercise therapy for early metabolic syndromePrincipal Investigator
- Principal Investigator
  
  Tsuchimochi Hirotsugu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Cardiovascular Center Research Institute
Influence of non-vascular cells in accelerated coronary aging in diabetes
- Principal Investigator
  
  Pearson James
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Role of pulmonary sympathetic nerves in the regulation of the pulmonary circulation by beta-receptors on pulmonary macrophages during chronic intermittent hypoxia
- Principal Investigator
  
  SHIRAI Mikiyasu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  National Cardiovascular Center Research Institute
Synchrotron radiation investigation of cardiac contractile protein dynamics at end diastole in a type 2 prediabetes model rat
- Principal Investigator
  
  SHIRAI Mikiyasu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Investigation of the mechanism of the exercise pressor reflex using a selective chemical denervation method.Principal Investigator
- Principal Investigator
  
  Tsuchimochi Hirotsugu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  National Cardiovascular Center Research Institute
Role of microvascular dysfunction in the cardiovascular center for development of hypertension
- Principal Investigator
  
  Shirai Mikiyasu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Fundamental study on developing heart failure treatment targeting the central nervous system.
- Principal Investigator
  
  SIRAI Mikiyasu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  National Cardiovascular Center Research Institute
How is cardiac parasympathetic nerve activity controlled during exercise?Principal Investigator
- Principal Investigator
  
  TSUCHIMOCHI Hirotsugu
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Sports science
- Research Institution
  National Cardiovascular Center Research Institute
動的運動時の心循環応答に対する副腎髄質の役割Principal Investigator
- Principal Investigator
  
  土持裕胤
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Sports science
- Research Institution
  Hiroshima University
骨リモデリングの交感神経性調節
- Principal Investigator
  
  松川寛二
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Hiroshima University
オーバートレーニング症候群における神経新生とモノアミン神経の形態変化Principal Investigator
- Principal Investigator
  
  土持裕胤
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Sports science
- Research Institution
  Hiroshima University
  Yamaguchi University
Studies on the protective mechanism of the fetal brain against hypoxic-ischemic insult during delivery
- Principal Investigator
  
  NAKAMURA Shoji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamaguchi University
Effects of hypoxia on caspase-3 activity in fetal superior colliculus : in vivo optical imagings
- Principal Investigator
  
  SAKATA Yoshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Yamaguchi University

All 2024 2023 2022 2019 2018 2017 2016 2015 2014 2013 2012 2011 2008 2007 Other

All Journal Article Presentation

[Journal Article] Increased contribution of KCa channels to muscle contraction induced vascular and blood flow responses in sedentary and exercise trained ZFDM rats2022
- Author(s)
  Sonobe T, Tsuchimochi H, Maeda H, Pearson JT.
- Journal Title
  
  J Physiol
  
  Volume: 600 (12) Issue: 12 Pages: 2919-2938
- DOI
  10.1113/jp282981
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K11358
[Journal Article] Using Synchrotron Radiation Imaging Techniques to Elucidate the Actions of Hexarelin in the Heart of Small Animal Models2022
- Author(s)
  Waddingham Mark T.、Tsuchimochi Hirotsugu、Sonobe Takashi、Asano Ryotaro、Jin Huiling、Ow Connie P. C.、Schwenke Daryl O.、Katare Rajesh、Aoyama Kohki、Umetani Keiji、Hoshino Masato、Uesugi Kentaro、Shirai Mikiyasu、Ogo Takeshi、Pearson James T.
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 12 Pages: 1-15
- DOI
  10.3389/fphys.2021.766818
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16498, KAKENHI-PROJECT-20K17137, KAKENHI-PROJECT-19H03405, KAKENHI-PROJECT-22K16121
[Journal Article] Liraglutide Improves Renal Endothelial Function in Obese Zucker Rats on a High-Salt Diet.2019
- Author(s)
  Sukumaran V, Tsuchimochi H, Sonobe T, Shirai M, Pearson JT
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 363(3) Issue: 3 Pages: 375-388
- DOI
  10.1124/jpet.118.254821
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05126
[Journal Article] Analysis of the microvascular morphology and hemodynamics of breast cancer in mice using SPring-8 synchrotron radiation microangiography.2017
- Author(s)
  Torii M, Fukui T, Inoue M, Kanao S, Umetani K, Shirai M, Inagaki T, Tsuchimochi H, Pearson JT, Toi M.
- Journal Title
  
  J Synchrotron Radiat
  
  Volume: 24 Issue: 5 Pages: 1039-1047
- DOI
  10.1107/s1600577517008372
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16033, KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-16K15452
[Journal Article] Influence of coronary architecture on the variability in myocardial infarction induced by coronary ligation in rats.2017
- Author(s)
  Kainuma S, Miyagawa S, Fukushima S, Tsuchimochi H, Sonobe T, Fujii Y, Pearson JT, Saito A, Harada A, Toda K, Shirai M, Sawa Y.
- Journal Title
  
  PLoS One
  
  Volume: 12(8) Issue: 8 Pages: e0183323-e0183323
- DOI
  10.1371/journal.pone.0183323
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-16K15452
[Journal Article] Azilsartan ameliorates diabetic cardiomyopathy in young db/db mice through the modulation of ACE-2/ANG 1-7/Mas receptor cascade.2017
- Author(s)
  Sukumaran V, Tsuchimochi H, Tatsumi E, Shirai M, Pearson JT.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 144 Pages: 90-99
- DOI
  10.1016/j.bcp.2017.07.022
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-16K15452
[Journal Article] Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model.2017
- Author(s)
  Pearson JT, Yoshimoto M, Chen YC, Sultani R, Edgley AJ, Nakaoka H, Nishida M, Umetani K, Waddingham MT, Jin HL, Zhang Y, Kelly DJ, Schwenke DO, Inagaki T, Tsuchimochi H, Komuro I, Yamashita S, Shirai M.
- Journal Title
  
  Sci Rep
  
  Volume: Dec 22;7(1) Issue: 1 Pages: 18108-18108
- DOI
  10.1038/s41598-017-18485-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16033, KAKENHI-INTERNATIONAL-15K21716, KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-17H02100, KAKENHI-PROJECT-16K15452
[Journal Article] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats.2016
- Author(s)
  Chen YC, Inagaki T, Fujii Y, Schwenke DO, Tsuchimochi H, Edgley AJ, Umetani K, Zhang Y, Kelly DJ, Yoshimoto M, Nagai H, Evans RG, Kuwahira I, Shirai M, Pearson JT.
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol.
  
  Volume: 311(2) Issue: 2 Pages: 426-439
- DOI
  10.1152/ajpregu.00112.2016
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05126, KAKENHI-PROJECT-26860165, KAKENHI-PROJECT-16K15452, KAKENHI-PROJECT-15K21692
[Journal Article] Pulmonary Macrophages Attenuate Hypoxic Pulmonary Vasoconstriction via β3AR/iNOS Pathway in Rats Exposed to Chronic Intermittent Hypoxia2015
- Author(s)
  Hisashi Nagai, Ichiro Kuwahira, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Sayoko Ogura, Takashi Sonobe, Tadakatsu Inagaki, Yutaka Fujii, Rutsuko Yamaguchi, Lisa Wingenfeld, Keiji Umetani, Tatsuo Shimosawa, Kenichi Yoshida, Koichi Uemura, James T. Pearson, Mikiyasu Shirai
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 7 Pages: 1-20
- DOI
  10.1371/journal.pone.0131923
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-26461262
[Journal Article] Ghrelin supresses sympathetic hyper-excitation in acute heart failure in male rats - assessing centrally and peripherally mediated pathways2015
- Author(s)
  Shirai M, Joe N, Tsuchimochi H, Sonobe T, Schwenke DO.
- Journal Title
  
  Endocrinology
  
  Volume: 156 Issue: 9 Pages: 3309-3316
- DOI
  10.1210/en.2015-1333
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670413
[Journal Article] APJ Regulates Parallel Alignment of Arteries and Veins in the Skin.2015
- Author(s)
  Kidoya H, Naito H, Muramatsu F, Yamakawa D, Jia W, Ikawa M, Sonobe T, Tsuchimochi H, Shirai M, Adams RH, Fukamizu A, Takakura N.
- Journal Title
  
  Dev Cell.
  
  Volume: 33 Issue: 3 Pages: 247-259
- DOI
  10.1016/j.devcel.2015.02.024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14380, KAKENHI-PROJECT-15K18409, KAKENHI-INTERNATIONAL-15K21737, KAKENHI-PROJECT-25250014, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-26830072, KAKENHI-PROJECT-24300330
[Journal Article] Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension.2015
- Author(s)
  Waddingham MT, Edgley AJ, Astolfo A, Inagaki T, Fujii Y, Du CK, Zhan DY, Tsuchimochi H, Yagi N, Kelly DJ, Shirai M, Pearson JT.
- Journal Title
  
  Cardiovasc Diabetol
  
  Volume: 14 Issue: 1 Pages: 92-105
- DOI
  10.1186/s12933-015-0256-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21692, KAKENHI-PROJECT-15F15119, KAKENHI-PROJECT-26670413, KAKENHI-PROJECT-25860184
[Journal Article] readmill running improves hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography.2015
- Author(s)
  Sonobe T, Tsuchimochi H, Schwenke DO, Pearson JT, Shirai M.
- Journal Title
  
  Cardiovasc Diabetol
  
  Volume: 13 Issue: 1
- DOI
  10.1186/s12933-015-0217-0
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670413
[Journal Article] Beta2-adrenergic receptor-dependent attenuation of hypoxic pulmonary vasoconstriction prevents progression of pulmonary arterial hypertension in intermittent hypoxic rats2014
- Author(s)
  Hisashi Nagai, Ichiro Kuwahira, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Akina Nara, Tadakatsu Inagaki, Sayoko Ogura, Yutaka Fujii, Keiji Umetani, Tatsuo Shimosawa, Kenichi Yoshida, James T. Pearson, Koichi Uemura, Mikiyasu Shirai
- Journal Title
  
  PLOS ONE
  
  Volume: 10 Issue: 10 Pages: 1-10
- DOI
  10.1371/journal.pone.0110693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-26461262, KAKENHI-PROJECT-26670413
[Journal Article] Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve　activity following chronic intermittent hypoxia2014
- Author(s)
  Mikiyasu Shirai, Hirotsugu Tsuchimochi, Hisashi Nagai, Emily Gray, James Todd Pearson, Takashi Sonobe, Misa Yoshimoto, Tadakatsu Inagaki, Yutaka Fujii, Keiji Umetani, Ichiro Kuwahira, Daryl Schwenke
- Journal Title
  
  Basic Research in Cardiology
  
  Volume: 109 Issue: 5 Pages: 432-432
- DOI
  10.1007/s00395-014-0432-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350547, KAKENHI-PROJECT-25860184, KAKENHI-PROJECT-26670413
[Journal Article] Synchrotro radiation imaging for advancing our understanding of ardiovascular function2013
- Author(s)
  Mikiyasu Shirai, Daryl O. Schwenke, Hirotsugu Tsuchimochi, Keiji Umetani, Naoto Yagi, James T. Pearson
- Journal Title
  
  Circ Res
  
  Volume: 112(1) Issue: 1 Pages: 209-221
- DOI
  10.1161/circresaha.111.300096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22500423, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24249086
[Journal Article] In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anaesthetized mice.2013
- Author(s)
  Zhan DY, Du CK, Akiyama T, Sonobe T, Tsuchimochi H, Shirai M.
- Journal Title
  
  Auton Neurosci
  
  Volume: 176(1-2) Issue: 1-2 Pages: 91-94
- DOI
  10.1016/j.autneu.2013.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24790791
[Journal Article] Impaired pulmonary blood flow distribution in congestive heart failure assessed using synchrotron radiation microangiography.2013
- Author(s)
  Shirai M, Beard M, Pearson JT, Son obe T, Tsuchimochi H, Fujii Y, Gray E, Umetani K. Schwenke DO.
- Journal Title
  
  J Synchrotron Radiat
  
  Volume: 20(3) Issue: 3 Pages: 441-448
- DOI
  10.1107/s0909049513007413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-25350547
[Presentation] Effect of Inhaled Nitric Oxide (iNO) Therapy on Myocardial Reverse Remodeling in a Rat Model of Cardiac Hypertrophy: Exploring New Potential for iNO2024
- Author(s)
  Hirotsugu Tsuchimochi
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K10603
[Presentation] Characterization of in vivo nitric oxide kinetics and its physiological function in inhaled nitric oxide therapy in rats2023
- Author(s)
  Hirotsugu Tsuchimochi
- Organizer
  CVMW2023 KOBE
- Data Source
  KAKENHI-PROJECT-23K10603
[Presentation] Effects of AMPK activation on skeletal muscle contraction-induced vasodilation in the hindlimb of non-obese type 2 diabetes Goto-Kakizaki rats2023
- Author(s)
  Sonobe T, Tsuchimochi H, Pearson JT.
- Organizer
  The 100th Anniversary Annual Meeting of The Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-21K11358
[Presentation] ラット骨格筋収縮に伴う血管拡張能の可視的機能評価2022
- Author(s)
  曽野部崇，土持裕胤，Pearson James
- Organizer
  第34回呼吸研究会
- Data Source
  KAKENHI-PROJECT-21K11358
[Presentation] Cerebrovascular function in several models of pregnancy induced hypertension in rats2022
- Author(s)
  土持　裕胤
- Organizer
  日本生理学会
- Data Source
  KAKENHI-PROJECT-20K11526
[Presentation] Changes in the Right Coronary Microcirculation in Pulmonary Arterial Hypertension.2019
- Author(s)
  Waddingham MT, Jin H, Sonobe , Tsuchimochi H, Asano R, Shirai M, Ogo T, Pearson JT.
- Organizer
  9th Federation of the Asian and Oceanian Physiological Societies Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] Liraglutide treatment improves the coronary microcirculation in Zucker obese rats on high-salt diet.2019
- Author(s)
  Sukumaran V, Tsuchimochi H, Sonobe T, Shirai M, Pearson JT.
- Organizer
  JCS 2019
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] Sympathetic control of the left ventricular functions during treadmill exercise in conscious rats2018
- Author(s)
  Tsuchimochi H, Pearson JT.
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-15K01642
[Presentation] Microangiography Reveals the Protective Role of Liraglutide on Renal Microvascular Impairment in Rats with Metabolic Syndrome.2018
- Author(s)
  Sukumaran V, Tsuchimochi H, Tatsumi E, Shirai M, Pearson JT
- Organizer
  J Am Soc Nephrol
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] Understanding the pathogenesis of diastolic dysfunction: from the whole heart to the level of the myofilament proteins.2018
- Author(s)
  Waddingham MT, Tsuchimochi H, Sonobe T, Hamdani N, Yagi N, Shirai M, Pearson JT, Ogo T
- Organizer
  The 2nd JCS Council Forum on Basic CardioVascular Research.
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] Liraglutide treatment improves renal vascular function in Zucker rats as visualized by microangiography.2017
- Author(s)
  Sukumaran V, Tsuchimochi H, Tatsumi E, Shirai M and Pearson JT.
- Organizer
  American Society of Nephrology meeting Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15452
[Presentation] Beta-blockade prevents coronary microvascular endothelial dysfunction in non-obese salt-sensitive insulin resistant rats on a high salt diet2017
- Author(s)
  H Tsuchimochi, H Thambyah, AJ Edgley, T Inagaki, MT Waddingham, YC Chen, CK Du, DY Zhan, V Sukumaran, T Sonobe, K Umetani, M Shirai, JT Pearson
- Organizer
  ESC Congress 2017（Barcelona)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15452
[Presentation] Bolus ghrelin administration ameliorates the inflammatory response and oxidative stress during percutaneous cardiopulmonary support in a rat model.2017
- Author(s)
  Sukumaran V, Tsuchimochi H, Tatsumi E, Shirai M and Pearson JT.
- Organizer
  Experimental Biology meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15452
[Presentation] Beta-blockade prevents coronary microvascular endothelial dysfunction in non-obese salt-sensitive insulin resistant rats on a high salt diet.2017
- Author(s)
  H Tsuchimochi, H Thambyah, AJ Edgley, T Inagaki, MT Waddingham, YC Chen, CK Du, DY Zhan, V Sukumaran, T Sonobe, K Umetani, M Shirai, JT Pearson
- Organizer
  ESC Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] Short term administration of azilsartan ameliorates diabetic cardiomyopathy in db/db mice.2017
- Author(s)
  Sukumaran Vijayakumar, Hirotsugu Tsuchimochi, Mikiyasu Shirai, James Pearson
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松
- Data Source
  KAKENHI-PROJECT-16K15452
[Presentation] Effect of insulin resistance on compound 21 mediated coronary microvascular dilation in female rats in vivo.2017
- Author(s)
  JT Pearson, P Meagher, H Tsuchimochi, AJ Edgley, M Yoshimoto, MT Waddingham, YC Chen, KM Mirabito Colafella, LM Hilliard, K Umetani, RE Widdop, M Shirai, KM Denton
- Organizer
  ESC Congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] 低酸素により誘発される心肥大におけるカルシニュリンB用蛋白質3（CHP3)の新しい役割2017
- Author(s)
  金美花、若林繁夫、古林創史、土持裕胤、白井幹康、ピアソン　ジェームズ、大郷剛
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松
- Data Source
  KAKENHI-PROJECT-16K15452
[Presentation] Bolus ghrelin administration ameliorates the inflammatory response and oxidative stress during percutaneous cardiopulmonary support in a rat model.2017
- Author(s)
  Sukumaran V, Tsuchimochi H, Tatsumi E, Shirai M and Pearson JT.
- Organizer
  Experimental Biology meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] Short term administration of azilsartan ameliorates diabetic cardiomyopathy in db/db mice2017
- Author(s)
  Sukumaran Vijayakumar, Hirotsugu Tsuchimochi, Mikiyasu Shirai, James T Pearson
- Organizer
  第９４回日本生理学会総会
- Place of Presentation
  アクトシティー浜松
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] 低酸素により誘発される心肥大におけるカルシニュリンB様蛋白質3（CHP3）の新しい役割2017
- Author(s)
  金美花，若林繁夫，古林創史，土持裕胤，白井幹康，ピアソンジェームズ，大郷剛
- Organizer
  第９４回日本生理学会総会
- Place of Presentation
  アクトシティー浜松
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] Liraglutide treatment improves renal vascular function in Zucker rats as visualized by microangiography2017
- Author(s)
  Sukumaran V, Tsuchimochi H, Tatsumi E, Shirai M and Pearson JT.
- Organizer
  American Society of Nephrology meeting Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] ローキナーゼ及び酸化ストレスによる心筋サルコメア機能の調節作用2017
- Author(s)
  JT Pearson, H Tsuchimochi, N Yagi, M Shirai
- Organizer
  第94回日本生理学会大会（浜松）
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] ローキナーゼ及び酸化ストレスによる心筋サルコメア機能の調節作用2017
- Author(s)
  ピアソン　ジェームズ、土持裕胤、八木直人、白井幹康
- Organizer
  第94回日本生理学会大会
- Place of Presentation
  アクトシティ浜松
- Data Source
  KAKENHI-PROJECT-16K15452
[Presentation] ローキナーゼ及び酸化ストレスによる心筋サルコメア機能の調節作用2017
- Author(s)
  ピアソンジェームズ，土持裕胤，八木直人，白井幹康
- Organizer
  第９４回日本生理学会総会
- Place of Presentation
  アクトシティー浜松
- Data Source
  KAKENHI-PROJECT-16H05126
[Presentation] ローキナーゼ及び酸化ストレスによる心筋サルコメア機能の調節作用2017
- Author(s)
  JT Pearson, H Tsuchimochi, N Yagi, M Shirai
- Organizer
  第94回日本生理学会大会（浜松）
- Data Source
  KAKENHI-PROJECT-16K15452
[Presentation] Fluorescence imaging guided identification of autonomic nerve fibers and the measurement of their activities in vivo by using Thy1-YFP transgenic mice.2016
- Author(s)
  Tsuchimochi H, Inagaki T, Shirai M.
- Organizer
  The 93rd Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Sapporo
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-26670413
[Presentation] Exercise training attenuates the development of diabetic cardiomyopathy through modulating inflammation and oxidative stress2016
- Author(s)
  Sukumaran V, Inagaki T, Tsuchimochi H, Shirai M.
- Organizer
  The 93rd Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Sapporo
- Year and Date
  2016-03-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670413
[Presentation] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in young insulin resistant Goto-Kakizaki rats.2016
- Author(s)
  Perason J, Chen Y, Inagaki T, Fujii, Y, Schwenke D, Edgley A, Umetani K, Zhan Y, Yoshimoto M, Tsuchimochi H, Nagai H, Kuwahira I, Evans R, Shirai M.
- Organizer
  The 93rd Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  Sapporo
- Year and Date
  2016-03-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670413
[Presentation] Fluorescence imaging guided identification of autonomic nerve fibers and the measurement of their activities in vivo by using Thy1-YFP transgenic mice2016
- Author(s)
  土持裕胤、稲垣薫克、白井幹康
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K01642
[Presentation] Ghrelin acts directly on the CNS to suppress cardiac sympathetic tone and arrhythmias following acute myocardial infarction in rats2015
- Author(s)
  Shirai M, Joe N, Tsuchimochi H, Schwenke DO
- Organizer
  92th Annual Meeting of Japan Physiological Society
- Place of Presentation
  Kobe International Conference Center
- Year and Date
  2015-03-21
- Data Source
  KAKENHI-PROJECT-26670413
[Presentation] Implications of adenosine and muscarinic acetylcholine receptors on bradycardia during systemic episodic hypoxia in rats2014
- Author(s)
  土持　裕胤
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島市、日本
- Data Source
  KAKENHI-PROJECT-23680067
[Presentation] 初期糖尿病ラットの拍動心臓で検出されたクロスブリッジ形成・解離の異常2013
- Author(s)
  白井幹康、ジェンキンス・マシュー、曽野部崇、藤井豊、土持裕胤、吉本光佐、稲垣薫克、八木直人
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23650213
[Presentation] 慢性低酸素により生じる右心室肥大におけるNCS-1の働き2013
- Author(s)
  稲垣薫克、土持裕胤、西谷友重、若林繁夫、白井幹康
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-23650213
[Presentation] Contributions of central command and exercise pressor reflex on myocardial perfusion during exercise in rats2013
- Author(s)
  Hirotsugu Tsuchimochi
- Organizer
  Experimental Biology 2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23680067
[Presentation] 視床下部歩行誘発野の刺激は麻酔下ラットの心筋組織血流量を増加させる2013
- Author(s)
  土持裕胤、曽野部崇、稲垣薫克、白井幹康
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-23650213
[Presentation] Stimulation of subthalamic locomotor region stimulates myocardial perfusion in anesthetized rats2013
- Author(s)
  土持　裕胤
- Organizer
  日本生理学会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-23680067
[Presentation] 意識下ラットおよびマウスにおける運動時心筋血流の直接計測2012
- Author(s)
  土持裕胤、曽野部崇、白井幹康
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  長野
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23650213
[Presentation] 意識下ラットおよびマウスにおける運動時心筋血流量の直接計測2012
- Author(s)
  土持裕胤, 曽野部崇, 白井幹康
- Organizer
  日本生理学会大会
- Place of Presentation
  松本市(長野県)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23680067
[Presentation] In vivo dynamic synchrotron imaging of coronary endothelial dysfunction in rats with early stage diabetes.2012
- Author(s)
  Shirai M, Jenkins M, Pearson J, Sonobe T, Fujii Y, Tsuchimochi H, Yoshimoto M, Umetani K
- Organizer
  89th Annual Meeting of the Physiological Society of Japa
- Place of Presentation
  松本市総合体育館（長野）
- Data Source
  KAKENHI-PROJECT-23650213
[Presentation] 放射光微小血管造影法によるラット糖尿病冠動脈内皮障害の初期病態の検出2012
- Author(s)
  白井幹康、ジェンキンス・マシュー、ピアソン・ジェームズ、曽野部崇、藤井豊、土持裕胤、吉本光佐、梅谷啓二
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  長野
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23650213
[Presentation] 意識下ラットにおける運動時心筋血流量の直接計測2011
- Author(s)
  土持裕胤, 曽野部崇, 白井幹康
- Organizer
  日本体力医学会大会
- Place of Presentation
  下関市(山口県)
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-23680067
[Presentation] Stimulation of subthalamic locomotor region evokes rapid increases inadrenal preganglionic sympathetic nerve activity catecholamineoutput in anesthetized rats.2008
- Author(s)
  土持裕胤
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  京王プラザホテル東京(東京都新宿区)
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19700522
[Presentation] Effect of gadolinium, a stretch-activated ion channel blocker. 0n the cardiovascular responses during dynamic exercise in cats.2007
- Author(s)
  土持裕胤
- Organizer
  Experimental Biology 2007
- Place of Presentation
  ワシントンコンベンションセンター,(アメリカ合衆国)
- Year and Date
  2007-04-29
- Data Source
  KAKENHI-PROJECT-19700522
[Presentation] Stimulation of subthalamic locomotor region increases adrenalsympathetic nerve activity and catecholamine output adrenalmedulla in anesthetized rats.2007
- Author(s)
  土持裕胤
- Organizer
  国際自律神経学会サテライトシンポジウム
- Place of Presentation
  グランヴィアホテル和歌山(和歌山市)
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19700522
[Presentation] 動的運動時の心拍数調節におけるTRPV1チャネルおよびカプサイシン感受性神経の役割
- Author(s)
  土持　裕胤
- Organizer
  第69回日本体力医学会大会
- Place of Presentation
  長崎県長崎市
- Year and Date
  2014-09-19 – 2014-09-21
- Data Source
  KAKENHI-PROJECT-23680067
[Presentation] The Role of TRPV1-Expressing Neurons in the Control of Heart Rate During Dynamic Exercise in Rats
- Author(s)
  土持　裕胤
- Organizer
  Experimental Biology 2015
- Place of Presentation
  Boston, USA
- Year and Date
  2015-03-28 – 2015-04-01
- Data Source
  KAKENHI-PROJECT-23680067
[Presentation] 麻酔下マウスの心機能評価における体温調節の重要性
- Author(s)
  土持　裕胤
- Organizer
  第92回日本生理学会大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-03-21 – 2015-03-23
- Data Source
  KAKENHI-PROJECT-23680067
[Presentation] Even Small Changes in Body Temperature Can Affect the Cardiac Function in Anesthetized Mice
- Author(s)
  土持　裕胤
- Organizer
  Experimental Biology 2015
- Place of Presentation
  Boston, USA
- Year and Date
  2015-03-28 – 2015-04-01
- Data Source
  KAKENHI-PROJECT-23680067
[Presentation] Abnormal cross-bridge dynamics in the in situ beating rat heart in early diabetes
- Author(s)
  Shirai M, Jenkins M, Sonobe T, Fujii Y, Tsuchimochi H, Yoshimoto M, Inagaki T, Yagi N
- Organizer
  90th Annual Meeting of the Physiological Society of Japan
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23650213

1. SIRAI Mikiyasu (70162758)

# of Collaborated Projects: 4 results

# of Collaborated Products: 36 results
2. Pearson James (30261390)

# of Collaborated Projects: 4 results

# of Collaborated Products: 26 results
3. TO Seikon (90590646)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. INAGAKI TADAKATSU (20638366)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. SAKATA Yoshiyuki (10034927)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. FUJIOKA Takashi (50304473)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ISHIKAWA Akinori (40363098)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. Sonobe Takashi (70548289)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. AKIYAMA Tsuyoshi (70202554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MORIMOTO Satio (50202362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAKAMURA Shoji (80112051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KIN Mika (40746773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. SEN Toun (30616941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 松川寛二 (90165788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 川口浩太郎 (60263703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 川口章 (30195052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 中岡良和 (90393214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 岩田裕子 (80171908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YAGI Naoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. UMETANI Keiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
21. KIDOYA Hiroyasu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. MURAMATSU Fumitaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. FUJII Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. ワディンガムマーク.トーマス

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsuchimochi Hirotsugu 土持 裕胤

TSUCHIMOCHI Hirotsugu 土持 裕胤

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How does daily exercise contribute to maintaining the elasticity of the heart?Principal Investigator

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Multi-layered elucidation of the effects of exercise therapy for early metabolic syndromePrincipal Investigator

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Investigation of the mechanism of the exercise pressor reflex using a selective chemical denervation method.Principal Investigator

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How is cardiac parasympathetic nerve activity controlled during exercise?Principal Investigator

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動的運動時の心循環応答に対する副腎髄質の役割Principal Investigator

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オーバートレーニング症候群における神経新生とモノアミン神経の形態変化Principal Investigator

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Tsuchimochi Hirotsugu 土持裕胤

TSUCHIMOCHI Hirotsugu 土持裕胤