INOUE Makoto 井上誠

Researcher Number	60380987
External Links
Affiliation (based on the past Project Information) *help	2008 – 2009: 長崎大学, 大学院・医歯薬学総合研究科, 准教授 2007: Nagasaki University, 大学院・医歯薬学総合研究科, 講師 2005 – 2006: 長崎大学, 大学院医歯薬学総合研究科, 講師 2004 – 2005: Nagasaki University, Graduate School of Biomedical Sciences, Assistant Professor, 大学院・医歯薬学総合研究科, 講師
Review Section/Research Field	Principal Investigator General pharmacology / Neurophysiology and muscle physiology / Nerve anatomy/Neuropathology Except Principal Investigator Biological Sciences / Environmental pharmacy / Biological pharmacy / Pain science / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator リゾホスファチジン酸 / 脂質 / 可塑性 / サブスタンスP / LPA1受容体 / グリア / 神経因性疼痛 / LPA合成酵素 / 知覚神経 / LPC産生 … More / LPA産生 / グリア細胞 / 脊髄 / 行動解析 / 動物 / 視床 / 神経 / ストレス / 脳 / MRI / 蛍光蛋白質 / ミオグロビン / 神経回路 / 初代培養細胞 / ネットワーク / WGA / 可視化 … More Except Principal Investigator MAP2 / 神経ステロイド / ストレス / tubulin / WGA / グルココルチコイド / HPA axis / ナノメディシン / ストレス性精神疾患 / NDI / STI / Ca^<2+> / FGF-1 / S100A13 / スパイン / アクチン / スプラウティング / リゾホスファチジン酸 / 脱髄 / 神経因性疼痛 / FRAP / Tashiro's carbonless medium / microorganism library / source of carbon / clean-up of waters / contamination / microorganism / endocrine disrupting chemicals / 無機培地 / ライブラリー / 炭素源 / 無毒化 / 汚染 / 微生物 / 環境ホルモン / serum starvation / non-vesicular release / Stress / S100 / 低酸素 / 核移行 / 分泌 / ネクローシス / 神経細胞死 / 無血清 / non-classical release / BDNF / Eph / Cre-loxP / プロサイモシンアルファー / LTP / WGA-EGFP / コルチコステロン / ex vivo培養 / 電子顕微鏡 / ミエリン関連タンパク質 / シュワン細胞 / 脱髄 / Ramak束 / ミエリンタンパク質 / アロディニア / MAG / 神経可塑性 / シナプス / 微小管 / 麻薬依存ストレス変調 / プロサイモシンアルファー / 虚血性神経変性疾患 / 神経ネットワーク可視化 / Tubulin / 神経因性疹痛 / 神経発芽 / LPA産生 / ex vivo解析 / LPA合成酵素 / ミエリン蛋白質 / Mass imaging / 線維筋痛症 / LPA de novo合成 / 脊髄損傷 / WGAトランスジーン法 / 神経回路 / 脂質 / 脳・神経 / QCM法 / X線結晶化構造解析 / 樹状突起 / 微小管制御ナノシステム Less

ストレス性精神疾患の可視化とナノメディシン
- Principal Investigator
  
  植田弘師
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
神経極性を形づくる微小管重合を制御する神経ステロイド
- Principal Investigator
  
  植田弘師
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Research on the allodynia-involved sprouting mechanisms
- Principal Investigator
  
  UEDA Mutsumi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Nagasaki University
ストレス性精神疾患の可視化とナノメディシン
- Principal Investigator
  
  植田弘師
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
線維筋痛症および視床痛動物モデルの開発Principal Investigator
- Principal Investigator
  
  井上誠
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Nagasaki University
神経因性疼痛原因分子リゾホスファチジン酸の産生と脊髄ミクログリア活性化機構の解明Principal Investigator
- Principal Investigator
  
  井上誠
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Nagasaki University
ストレス性精神疾患の可視化とナノメディシン
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
神経極性を形づくる微小管重合を制御する神経ステロイド
- Principal Investigator
  
  植田弘師
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Identification of molecular targets to cure intractable neuropathic pain with nerve injury-induced demyelination
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Nagasaki University
特定中枢神経ネットワークのMRIによる非侵害的可視化技術の開発Principal Investigator
- Principal Investigator
  
  井上誠
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Nagasaki University
Functional proteomics analysis of non-vesicular release mechanisms in stress exposed neuron-role of stress-induced non-vesicular release Prion, NDI and FGF-1 in neuron
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
Preparation of microorganism library derived from soils of seacoast, river and lakes, and its utilization for the environmental clean-up from endocrine disrupting chemicals.
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Nagasaki University

All 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-induced Neuropathic Pain.2010
- Author(s)
  Ma L, Uchida H, Nagai J, Inoue M, Aoki J, Ueda H.
- Journal Title
  
  J Pharmacol Exp Ther. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist.2009
- Author(s)
  Ma L, Matsumoto M, Xie W, Inoue M, Ueda H.
- Journal Title
  
  J Neurochem 109(2)
  
  Pages: 603-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.2009
- Author(s)
  Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H.
- Journal Title
  
  Mol Pain 5
  
  Pages: 64-64
- NAID
  120006984666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain.2008
- Author(s)
  Inoue M, Ma L, Aoki J, Ueda H.
- Journal Title
  
  J Neurochem 107(6)
  
  Pages: 1556-65
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Simultaneous stimulation of spinal neurokinin 1 and NMDA receptors produces lysophosphatidylcholine, which undergoes autotaxin-mediated conversion to lysophosphatidic acid, an initiator of neuropathic pain2008
- Author(s)
  Inoue M, Ma L, Aoki J, Ueda H
- Journal Title
  
  J. Neurochem 107(6)
  
  Pages: 1556-1565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603008
[Journal Article] Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid2008
- Author(s)
  Makoto Inoue
- Journal Title
  
  Neuroscience
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603008
[Journal Article] Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.2008
- Author(s)
  Makoto Inoue
- Journal Title
  
  Neuroscience 152
  
  Pages: 296-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689010
[Journal Article] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.2008
- Author(s)
  Makoto Inoue
- Journal Title
  
  Molecular Pain 4
  
  Pages: 6-6
- NAID
  120006982424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18689010
[Journal Article] Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain2008
- Author(s)
  Makoto Inoue
- Journal Title
  
  Journal of Neurochemistry 107
  
  Pages: 1556-1565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.2008
- Author(s)
  Inoue M, Xie W, Matsushita Y, Chun J, Aoki J, Ueda H.
- Journal Title
  
  Neuroscience 152(2)
  
  Pages: 296-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Prothymosin alpha plays a key role in cell death mode-switch, a new concept for neurorrotective mechanisms in stroke.2008
- Author(s)
  Makoto Inoue
- Journal Title
  
  Molecular pain
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603008
[Journal Article] Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid2008
- Author(s)
  Makoto Inoue
- Journal Title
  
  Neuroscience (掲載確定)
  
  Pages: 296-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603008
[Journal Article] Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid2008
- Author(s)
  Inoue M, Xie W, Matsushita Y, Chun J, Aoki J, Ueda H
- Journal Title
  
  Neuroscience 152(2)
  
  Pages: 296-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603008
[Journal Article] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain2008
- Author(s)
  Makoto Inoue
- Journal Title
  
  Molecular Pain (E-pub)
- NAID
  120006982424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid2008
- Author(s)
  Makoto Inoue
- Journal Title
  
  Neuroscience 152
  
  Pages: 296-298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain2008
- Author(s)
  Makoto Inoue
- Journal Title
  
  Journal of Neurochermistry 107
  
  Pages: 1556-1565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603008
[Journal Article] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.2008
- Author(s)
  Inoue M, Ma L, Aoki J, Chun J, Ueda H.
- Journal Title
  
  Mol Pain 4
  
  Pages: 6-6
- NAID
  120006982424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] 神経傷害時の有髄A線維におけるトランスアクティベーション機構2007
- Author(s)
  井上誠
- Journal Title
  
  ペインクリニック 28
  
  Pages: 1013-1018
- Data Source
  KAKENHI-PROJECT-18689010
[Journal Article] 神経傷害時の有髄A線維におけるトランスアクティベーション機構ペインクリニック2007
- Author(s)
  井上誠, 植田弘師
- Journal Title
  
  28
  
  Pages: 1013-1018
- Data Source
  KAKENHI-PROJECT-19603008
[Journal Article] 神経傷害時の有髄A線維におけるトランスアクティベーション機構2007
- Author(s)
  井上誠
- Journal Title
  
  ペインクリニック 28
  
  Pages: 1013-1018
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Loss of spinal substance P pain transmission under the condition of LPA 1 receptor-mediated neuropathic pain.2006
- Author(s)
  Inoue et al.
- Journal Title
  
  Mol Pain 2
  
  Pages: 25-25
- NAID
  120006982430
- Data Source
  KAKENHI-PROJECT-18689010
[Journal Article] Inhibition of paclitaxel-Induced A-Fiber hypersensitization by gabapentin.2006
- Author(s)
  Matsumoto M, Inoue M, Hald A, Xie W, Ueda H
- Journal Title
  
  J Pharmacol Exp Ther. 318(2)
  
  Pages: 735-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain.2006
- Author(s)
  Inoue M, Yamaguchi A, Kawakami M, Chun J, Ueda H.
- Journal Title
  
  Mol Pain 2
  
  Pages: 25-25
- NAID
  120006982430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17109015
[Journal Article] Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain.2006
- Author(s)
  Inoue M
- Journal Title
  
  Mol Pain 2
  
  Pages: 25-29
- NAID
  120006982430
- Data Source
  KAKENHI-PROJECT-17109015
[Presentation] The de novo biosynthesis of lysophosphatidic acid (LPA), an initiator of neuropathic pain, following intense stimulation of primary afferent fiber2009
- Author(s)
  井上誠
- Organizer
  第82回日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-17109015
[Presentation] The de novo biosynthesis of lysophosphatidic acid (LPA), an initiator of neuropathic pain, following intense stimulation of primary afferent fiber2009
- Author(s)
  Inoue M, Ueda H
- Organizer
  第82 回日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-19603008
[Presentation] The de novo biosynthesis of lysophosphatidic acid (LPA), an initiator of neuropathic pain, following intense stimulation of primary afferent fiber2009
- Author(s)
  井上誠
- Organizer
  第82回日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2009-03-16
- Data Source
  KAKENHI-PROJECT-19603008
[Presentation] Autotaxin mediates the induction of nerve-injured neuropathic pain through the synthetic enzymic action for lysophosphatidic acid (LPA)2008
- Author(s)
  Ma L, Inoue M, Ueda H
- Organizer
  Asian Pain 2008
- Place of Presentation
  福岡
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19603008
[Presentation] Critical time period for lysophosphatidic acid (LPA)-signaling in nerve injury-typed neuropathic pain2008
- Author(s)
  Ma L, Inoue M, Ueda H
- Organizer
  第31 回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-19603008
[Presentation] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA)from lysophosphatidylcholine (LPC), initiates the sciatic nerve injury-induced neuropathic pain2008
- Author(s)
  Makoto Inoue
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington D. C
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-19603008
[Presentation] Nicotine analgesia and primary afferent cholinergic neuron2008
- Author(s)
  Matsumoto M, Inoue M, Ueda H
- Organizer
  Asian Pain 2008(第30回日本疼痛学会)
- Place of Presentation
  福岡
- Year and Date
  2008-07-20
- Data Source
  KAKENHI-PROJECT-19603008
[Presentation] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC), initiates the sciatic nerve injury-induced neuropathic pain2008
- Author(s)
  Makoto Inoue
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington D. C
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-17109015
[Presentation] Autotaxin, a synthetic enzyme of lysophosphatidicacid (LPA) from lysophosphatidylcholine (LPC), mediates the induction of nerve-injured neuropathic pain2008
- Author(s)
  Xie W, Inoue M, Ueda H
- Organizer
  第31 回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-19603008
[Presentation] Lysophosphatidylcholine (LPC) hydrolyzed by autotoxin/ATX into lysophosphatidic acid (LPA), induces neuropathic pain through LPA1 receptor2008
- Author(s)
  Xie W, Inoue M, Ueda H
- Organizer
  Asian Pain 2008
- Place of Presentation
  福岡
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19603008
[Presentation] Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC), initiates the sciatic nerve injury-induced neuropathic pain2008
- Author(s)
  Inoue M, Ueda H
- Organizer
  Society for Neuroscience
- Place of Presentation
  Washington D. C
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-19603008

1. UEDA Hiroshi (00145674)

# of Collaborated Projects: 10 results

# of Collaborated Products: 8 results
2. FUJITA Ryousuke (70380855)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. UEDA Mutsumi (30437834)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. UCHIDA Hitoshi (30549621)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 水野恭伸 (40311865)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 吉田明 (70257187)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. SUMIKAWA Koji (60028660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAKAGUCHI Suehiro (60274635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 芳本忠 (60088870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

INOUE Makoto 井上 誠

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線維筋痛症および視床痛動物モデルの開発Principal Investigator

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神経因性疼痛原因分子リゾホスファチジン酸の産生と脊髄ミクログリア活性化機構の解明Principal Investigator

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特定中枢神経ネットワークのMRIによる非侵害的可視化技術の開発Principal Investigator

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[Journal Article] Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-induced Neuropathic Pain.2010

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[Journal Article] Evidence for lysophosphatidic acid 1 receptor signaling in the early phase of neuropathic pain mechanisms in experiments using Ki-16425, a lysophosphatidic acid 1 receptor antagonist.2009

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[Journal Article] Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.2009

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INOUE Makoto 井上誠