Shimoda Masashi 下田将司

… Alternative Names

SHIMODA Masashi 下田将司

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Researcher Number	60388957
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2024: 川崎医科大学, 医学部, 講師 2014 – 2022: 川崎医科大学, 医学部, 講師 2007: Kawasaki Medical School, Department of Medicine, Assistant 2006: 川崎医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator 消化管糖輸送 / SGLT2阻害薬 / 臓器連関 / 糖代謝 / 糖尿病 / インクレチン / 消化管 / 腎臓 Except Principal Investigator インスリン転写因子 / ブドウ糖毒性 … More / 膵β細胞 / 糖尿病 / RNAメチレーション / 膵β細胞ブドウ糖毒性 / SGLT2阻害薬 / インクレチン受容体 / 新規糖尿病治療薬 / 膵β細胞糖毒性 / 転写因子 / インスリン遺伝子 / β-cell restoration / β-cell mass / oxidative stress / pioglitazone / diet therapy / LCM method / impaired β-cell function / db gene / 肥満2型糖尿病モデル / 膵ラ氏島遺伝子発現 / 膵β細胞機能 / db遺伝子ヘテロ接合体マウス / db遺伝子ホモ接合体マウス / 膵β細胞機能保護 / 膵β細胞量 / 酸化ストレス / ピオグリタゾン / 食事介入 / LCM法 / 膵β細胞機能不全 / db遺伝子 / endosome / インスリン / グルカゴン / GKラット / GLP-1R / GLP-1産生細胞 / 膵ラ氏島α細胞 / 糖尿病GKラット / 膵ラ氏島GLP-1のparacrine機構 / 膵ラ氏島GLP-1のautocrine機構 / 膵GLP-1受容体 / 膵GLP-1分泌 / autocrine作用 / GLP-1受容体 / GLP-1 / 膵α細胞 / 膵インクレチン / 膵灌流 / 膵ラ氏島機能 Less

ブドウ糖毒性が膵ラ氏島のm6A RNAメチル化不全に与える影響
- Principal Investigator
  
  木村友彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
Renal-Gastrointestinal Interactions in the Regulation of Glucose MetabolismPrincipal Investigator
- Principal Investigator
  
  Shimoda Masashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
Comprehensive searching for compounds which can directly enhance MafA and/or PDX-1 expression
- Principal Investigator
  
  Kaneto Hideaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kawasaki Medical School
Investigation of novel diabetic medicine based on glucose toxicity
- Principal Investigator
  
  Hideaki Kaneto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
Influence to type 2 diabetes by SGLT2 inhibitor ; Elucidation of link between kidney and intestinePrincipal Investigator
- Principal Investigator
  
  Shimoda Masashi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
Physiological role of pancreatic incretin on the functional regulation of pancreatic islet cells
- Principal Investigator
  
  Kaku Kohei
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School
Research for molecular mechanism of diabetes development in obese type 2 diabetes model db/db mice
- Principal Investigator
  
  KAKU Kohei
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kawasaki Medical School

All 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Favorable effects of GLP-1 receptor activator against pancreatic beta-cell glucose toxicity and the development of arteriosclerosis: “The earlier, the better” in therapy with incretin-based medicine.2021
- Author(s)
  Kaneto H, Kimura T, Shimoda M, Obata A, Sanada J, Fushimi Y, Nakanishi S, Mune T, and Kaku K.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 22 Issue: 15 Pages: 7917-7917
- DOI
  10.3390/ijms22157917
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
[Journal Article] Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class2021
- Author(s)
  Kaneto H, Obata A, Kimura T, Shimoda M, Kinoshita T, Matsuoka TA, Kaku K.
- Journal Title
  
  Int J Mol Sci .
  
  Volume: 22 Issue: 6 Pages: 3062-3062
- DOI
  10.3390/ijms22063062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18016, KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
[Journal Article] Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History2021
- Author(s)
  Kaneto H, Kimura T, Obata A, Shimoda M, Kaku K.
- Journal Title
  
  Int J Mol Sci .
  
  Volume: 22 Issue: 5 Pages: 2596-2596
- DOI
  10.3390/ijms22052596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18016, KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-21K08540
[Journal Article] Notable underlying mechanism for pancreatic beta-cell dysfunction and atherosclerosis: Pleiotropic role of incretin and insulin signaling in various situation.2020
- Author(s)
  Kaneto H, Obata A, Kimura T, Shimoda M, Sanada J, Fushimi Y, Katakami N, Matsuoka T, and Kaku K.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 24 Pages: 1-13
- DOI
  10.3390/ijms21249444
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08990, KAKENHI-PROJECT-19K18016
[Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019
- Author(s)
  Obata A, Kimura T, Obata Y, Shimoda M, Kinoshita T, Kohara K, Okauchi S, Hirukawa H, Kamei S, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetologia
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019
- Author(s)
  Obata A, Kimura T, Obata Y, Shimoda M, Kinoshita T, Kohara K, Okauchi S, Hirukawa H, Kamei S, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetologia
  
  Volume: 62 Issue: 12 Pages: 1225-1236
- DOI
  10.1007/s00125-019-04982-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08990
[Journal Article] Durability of protective effect of dulaglutide on pancreatic beta-cells in diabetic mice: GLP-1 receptor expression is not reduced at all even after long-term exposure to dulaglutide.2018
- Author(s)
  Kimura T, Obata A, Shimoda M, Hirukawa H, Kanda-Kimura Y, Nogami Y, Kohara K, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetes Metab.
  
  Volume: 44 Pages: 250-260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic beta-cells in obese diabetic db/db mice: The earlier and longer, the better.2018
- Author(s)
  Kimura T, Obata A, Shimoda M, Okauchi S, Kanda-Kimura Y, Nogami Y, Hirukawa H, Kohara K, Nakanishi S, Mune T, Kaku K, and Kaneto H.
- Journal Title
  
  Diabetes Obes. Metab.
  
  Volume: 20 Pages: 2442-2457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Pancreatic alpha-cells in diabetic rats express active GLP-1 receptor: Evidence for GLP-1 signaling that regulates intra-islet paracrine mechanism.2018
- Author(s)
  Nakashima K, Kaneto H, Shimoda M, Kimura T, and Kaku K.
- Journal Title
  
  Scientific Rep.
  
  Volume: 1 Issue: 1 Pages: 1-14
- DOI
  10.1038/s41598-018-21751-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Increase of cortisol / ACTH ratio after chronic treatment with liraglutide in subjects with type 2 diabetes mellitus.2017
- Author(s)
  Kamei S, Kaneto H, Tanabe A, Kinoshita T, Obata A, Kimura T, Hirukawa H, Tatsumi F, Shimoda M, Kohara K, Anno T, Nakanishi S, Mune T, and Kaku K.
- Journal Title
  
  Diabetes Metab
  
  Volume: 43 Issue: 4 Pages: 398-399
- DOI
  10.1016/j.diabet.2017.01.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Beneficial effects of SGLT2 inhibitors for preservation of pancreatic beta-cell function and reduction of insulin resistance.2017
- Author(s)
  Kaneto H, Obata A, Kimura T, Shimoda M, Okauchi S, Shimo N, Matsuoka T, and Kaku K.
- Journal Title
  
  J. Diabetes
  
  Volume: 9 Issue: 3 Pages: 219-225
- DOI
  10.1111/1753-0407.12494
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice.2016
- Author(s)
  Okauchi S, Shimoda M, Obata A, Kimura T, Hirukawa H, Kohara K, Mune T, Kaku K, Kaneto H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 470 Issue: 3 Pages: 772-782
- DOI
  10.1016/j.bbrc.2015.10.109
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461350, KAKENHI-PROJECT-16K09770
[Journal Article] Clinical effects of liraglutide are possibly influenced by hypertriglyceridemia and remaining pancreatic beta-cell function in subjects with type 2 diabetes mellitus.2016
- Author(s)
  Tanabe A, Kaneto H, Kamei S, Hirukawa H, Shimoda M, Kimura T, Obata A, Okauchi S, Tatsumi F, Kohara K, Mune T, and Kaku K.
- Journal Title
  
  J. Diabetes Complications
  
  Volume: 30 Pages: 1201-1203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Promising diabetes therapy based on the molecular mechanism for glucose toxicity: Usefulness of SGLT2 inhibitors as well as incretin-related drugs.2016
- Author(s)
  Kaneto H, Obata A, Shimoda M, Kimura T, Hirukawa H, Okauchi S, Matsuoka T, and Kaku K.
- Journal Title
  
  Curr. Med. Chem.
  
  Volume: 23 Pages: 3044-3051
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09770
[Journal Article] Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes.2015
- Author(s)
  Kimura T, Kaneto H, Shimoda M, Hirukawa H, Okauchi S, Kohara K, Hamamoto S, Tawaramoto K, Hashiramoto S, Kaku K
- Journal Title
  
  Mol Cell Endocrinol
  
  Volume: 400 Pages: 78-89
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461350
[Journal Article] Dietary restriction preserves the mass and function of pancreatic β cells via cell kinetic regulation and suppression of oxidative/ER stress in diabetic mice.2015
- Author(s)
  Kanda Y, Hashiramoto M, Shimoda M, Hamamoto S, Tawaramoto K, Kimura T, Hirukawa H, Nakajima K, Kaku K
- Journal Title
  
  J Nutr Biochem
  
  Volume: 26 Pages: 219-226
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461350
[Journal Article] Combination of DPP-4 inhibitor and PPARγ agonist exerts protective effects on pancreatic β-cells in diabetic db/db mice through the augmentation of IRS-2 expression.2015
- Author(s)
  Hirukawa H, Kaneto H, Shimoda M, Kimura T, Okauchi S, Obata A, Kohara K, Hamamoto S, Tawaramoto K, Hashiramoto M, Kaku K
- Journal Title
  
  Mol Cell Endocrinol
  
  Volume: 413 Pages: 49-60
- DOI
  10.1016/j.mce.2015.06.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461350
[Presentation] Effects of luseogliflozin on intestinal glucose absorption in diabetic mice: -Upregulation of glucose transporter expression by chronic treatment with luseogliflozin2017
- Author(s)
  Masashi Shimoda, Atsushi Obata, Seizo Okauchi, Tomohiko Kimura, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku and Hideaki Kaneto
- Organizer
  77th Scientific Sessions , American Diabetes Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19548
[Presentation] SGLT2阻害薬Luseogliflozinの慢性投与は消化管糖輸送担体発現を増加させ, 消化管糖吸収を促進する2017
- Author(s)
  下田将司, 小畑淳史,木下智絵, 木村友彦, 小原健司, 中西修平, 加来浩平, 金藤秀明
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19548
[Presentation] 糖尿病モデルラットのα細胞におけるGIP/GIP受容体の発現とGLP-1/GLP-1受容体との相違性2016
- Author(s)
  中島弘二、金藤秀明、木村友彦、下田将司、加来浩平
- Organizer
  第５９回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26461350
[Presentation] 糖尿病モデルラットのα細胞におけるGIP/GIP受容体の発現とGLP-1/GLP-1受容体との相違性2016
- Author(s)
  中島弘二、金藤秀明、木村友彦、下田将司、加来浩平
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26461350
[Presentation] 膵α細胞および消化管由来のGLP-1とGIPの分泌機構の相違性
- Author(s)
  中島弘二、下田将司、木村友彦、蛭川英典、岡内省三、加来浩平
- Organizer
  第５７回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26461350
[Presentation] 糖尿病モデルラット膵α細胞にはGLP-1受容体が発現しGLP-1のautocrine機構が存在する
- Author(s)
  中島弘二、木村友彦、岡内省三、下田将司、金藤秀明、加来浩平
- Organizer
  第５８回日本糖尿病学会年次学術集会
- Place of Presentation
  海峡メッセ下関（山口県下関市）
- Year and Date
  2015-05-21 – 2015-05-23
- Data Source
  KAKENHI-PROJECT-26461350

1. Hideaki Kaneto (80448034)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
2. 小畑淳史 (10771298)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
3. 木村友彦 (50454830)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
4. Kaku Kohei (10116709)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. KOTANI Ko (10388928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HASHIRAMOTO Mitsuru (40346680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KANDA Yukiko (40351895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 片倉幸乃 (40858247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 真田淳平 (70771301)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKASHIMA Koji

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. HIRUKAWA Hidenori

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. OKAUCHI Seizo

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. SHIGETO Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. IKEDA Shiori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NOGAMI Yuka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Rorsman Patrik

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Shimoda Masashi 下田 将司

SHIMODA Masashi 下田 将司

Research Projects

Research Products

Co-Researchers

ブドウ糖毒性が膵ラ氏島のm6A RNAメチル化不全に与える影響

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Renal-Gastrointestinal Interactions in the Regulation of Glucose MetabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive searching for compounds which can directly enhance MafA and/or PDX-1 expression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of novel diabetic medicine based on glucose toxicity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Influence to type 2 diabetes by SGLT2 inhibitor ; Elucidation of link between kidney and intestinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Physiological role of pancreatic incretin on the functional regulation of pancreatic islet cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for molecular mechanism of diabetes development in obese type 2 diabetes model db/db mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Favorable effects of GLP-1 receptor activator against pancreatic beta-cell glucose toxicity and the development of arteriosclerosis: “The earlier, the better” in therapy with incretin-based medicine.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Notable underlying mechanism for pancreatic beta-cell dysfunction and atherosclerosis: Pleiotropic role of incretin and insulin signaling in various situation.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019

Author(s)

Journal Title

Data Source

[Journal Article] Vascular endothelial PDK1 plays pivotal roles for maintenance of pancreatic beta-cell mass and function in adult male mice.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Durability of protective effect of dulaglutide on pancreatic beta-cells in diabetic mice: GLP-1 receptor expression is not reduced at all even after long-term exposure to dulaglutide.2018

Author(s)

Journal Title

Data Source

Shimoda Masashi 下田将司

SHIMODA Masashi 下田将司