ISOBE Aki 磯部晶

Researcher Number	60397619
Affiliation (based on the past Project Information) *help	2011 – 2016: 大阪大学, 医学(系)研究科(研究院), 助教 2013 – 2015: 大阪大学, 医学系研究科, 助教 2011: 大阪大学, 大学院・医学研究科, 助教 2010 – 2011: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology
Keywords	Principal Investigator IL-6 / 腹膜播種 / 卵巣癌腹膜播種 / IL-６ / M2ﾏｸﾛﾌｧｰｼﾞ / M2マクロファージ / 骨髄由来細胞 / tocilizumab / TAM / 卵巣癌 … More Except Principal Investigator … More 卵巣癌 / 低酸素刺激 / マイクロRNA / 腹膜播種 / パクリタキセル耐性 / エクソソーム / 卵巣がん / バイオマーカー / CD44 miR-99a / paclitaxel / exosome / microRNA / peritoneal dissemination / Ovarian cancer / 接着 / 接着因子 / 子宮内膜症 / PlGF / NF-κBシグナル / 分子標的治療 / 抗血管新生治療 / VEGF / NF-κB シグナル / 抗血管新生療法 / Eカドヘリン / 脱落膜細胞 / 絨毛細胞 / 絨毛羊膜炎 / プロスタグランジン / インターロイキン / 前期破水 / 常位胎盤早期剥離 / 骨髄由来細胞 / 腹膜中皮細胞 / everolimus / 卵巣明細胞腺癌 / 明細胞腺癌 / 耐性化機構 / Trabectedin / 耐性化 / mTORC1阻害薬 / mTORC1 / mTORC2 Less

Why is the treatment of peritoneal dissemination so difficult? Analyses focusing on microRNA and exosome.
- Principal Investigator
  
  Sawada Kenjiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Investigate the adhesion molecules that control the progression of endometriosis.
- Principal Investigator
  
  Hashimoto Kae
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Devoleping a novel anti-angiogenic therapy focused on placental growth factor secreted by ovarian cancer cells
- Principal Investigator
  
  SAKATA Masahiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Identification of myeloid derived cells which regulates ovarian cancer disseminationPrincipal Investigator
- Principal Investigator
  
  ISOBE Aki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Potential role of mTORC2 as a therapeutic target in epithelial ovarian cancer
- Principal Investigator
  
  MABUCHI Seiji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Identification of micro RNAs which affected by tumor microenvironments of ovarian cancer and analysis of a potential as a therapeutic target
- Principal Investigator
  
  SAWADA Kenjiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
The molecular analysis of placental abruption using in vitro placental model
- Principal Investigator
  
  KIMURA Tadashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Analysis of functional role of intereukin-6 secreted by tumor-associated macrophage in ovarian cancer ascitesPrincipal Investigator
- Principal Investigator
  
  ISOBE Aki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University

All 2015 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] IKKβ Regulates VEGF Expression and Is a Potential Therapeutic Target for Ovarian Cancer as an Anti-angiogenic Treatment2015
- Author(s)
  Kinose, Y. Sawada, K. Makino, H. Ogura, T. Mizuno, T. Suzuki, N. Fujikawa, T. Morii, E. Nakamura, K. Sawada, I. Toda, A. Hashimoto, K. Isobe, A. Mabuchi, S. Ohta, T. Itai, A. Morishige, K. I. Kurachi, H. Kimura, T
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 14 Issue: 4 Pages: 909-19
- DOI
  10.1158/1535-7163.mct-14-0696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592515, KAKENHI-PROJECT-26293360, KAKENHI-PROJECT-26462519, KAKENHI-PROJECT-26670725
[Journal Article] Interleukin 6 receptor is an independent prognostic factor and a potential therapeutic target of ovarian cancer.2015
- Author(s)
  Isobe A, Sawada K, Kinose Y, Ohyagi-Hara C, Nakatsuka E, Makino H, Ogura T, Mizuno T, Suzuki N, Morii E, Nakamura K, Sawada I, Toda A, Hashimoto K, Mabuchi S, Ohta T, Morishige K, Kurachi H, Kimura T.
- Journal Title
  
  PloS One
  
  Volume: 10 Issue: 2 Pages: e0118080-e0118080
- DOI
  10.1371/journal.pone.0118080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293360
[Journal Article] miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression2013
- Author(s)
  Ohyagi-Hara C, Sawada K, Mabuchi S, Takahashi T, Kurachi H
- Journal Title
  
  Am J Pathol
  
  Volume: 182(5) Issue: 5 Pages: 1876-1889
- DOI
  10.1016/j.ajpath.2013.01.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390308, KAKENHI-PROJECT-23592443, KAKENHI-PROJECT-23592447, KAKENHI-PROJECT-23890102, KAKENHI-PROJECT-24249080, KAKENHI-PROJECT-24590459, KAKENHI-PROJECT-24659723, KAKENHI-PROJECT-25293342, KAKENHI-PROJECT-25462588
[Journal Article] miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin alpha5 Expression2013
- Author(s)
  Ohyagi-Hara, C. Sawada, K. Kamiura, S. Tomita, Y. Isobe, A. Hashimoto, K. Kinose, Y. Mabuchi, S. Hisamatsu, T. Takahashi, T. Kumasawa, K. Nagata, S. Morishige, K. I. Lengyel, E. Kurachi, H. Kimura, T.
- Journal Title
  
  Am J Pathol
  
  Volume: 182 Pages: 1876-1889
- Data Source
  KAKENHI-PROJECT-23592447
[Journal Article] Aldosterone stimulates the proliferation of uterine leiomyoma cells.2010
- Author(s)
  Isobe A, Takeda T, Wakabayashi A, Tsuiji K, Li B., et al.
- Journal Title
  
  Gynecol Endocrinol
  
  Volume: 26 Pages: 372-377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791529
[Presentation] The significance of vascular endothelial growth factor C in the lymphangiogenesis and lymph node metastasis of ovarian cancer2013
- Author(s)
  Hisamatsu, T. Mabuchi, S. Sasano, T. Takahashi, R. Kawano, M. Matsumoto, Y. Hashimoto, K. Isobe, A. Sawada, K. Sakata, M. Kimura, T.
- Organizer
  The 104th Annual Meeting American Association for Cancer Research
- Place of Presentation
  Washington DC, U.S.A
- Data Source
  KAKENHI-PROJECT-23592446
[Presentation] 卵巣癌組織におけるインターロイキン6(IL-6)とその受容体の発現が予後に与える影響の解析2013
- Author(s)
  磯部晶澤田健二郎小倉寛則木瀬康人川島英理子牧野弘水野智子木村正森重健一郎
- Organizer
  第65回日本産科婦人科学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24791702
[Presentation] 卵巣癌進展を制御する腹水骨髄由来細胞の同定とその役割の解析2013
- Author(s)
  磯部晶
- Organizer
  第66回日本産科婦人科学会学術講演会
- Place of Presentation
  さっぽろ芸文館
- Year and Date
  2013-05-12
- Data Source
  KAKENHI-PROJECT-24791702
[Presentation] 卵巣癌組織におけるインターロイキン6(IL-6)とその受容体の発現が予後に与える影響の解析2013
- Author(s)
  磯部晶. 澤田健二郎. 小倉寛則. 木瀬康人. 川島英理子. 牧野弘. 水野智子.木村正. 森重健一郎
- Organizer
  第65回日本産科婦人科学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659779
[Presentation] 卵巣癌組織におけるインターロイキン 6 (IL-6) とその受容体の発現が予後に与える影響の解析2013
- Author(s)
  磯部晶
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2013-04-18
- Data Source
  KAKENHI-PROJECT-24791702
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第52回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659779
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-23592447
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-24791702
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-23592446
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第52回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592447
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-23659779
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第52回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23592446
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第52回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第52回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24791702
[Presentation] 上皮性卵巣癌におけるmTOR complex 2 (mTORC2) の発現とその臨床的意義の検討2012
- Author(s)
  久松武志、馬淵誠士、河野まひる、橋本香映、磯部晶、澤田健二郎、木村正
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 卵巣がん進展時の腹水中に大量に存在する骨髄由来細胞が果たす役割の解明2011
- Author(s)
  磯部晶.澤田健二郎.大八木知史.若林敦子.馬淵誠士.森重健一郎.木村正
- Organizer
  第63回日本産科婦人科学会
- Place of Presentation
  大阪
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22791529
[Presentation] Analysis of functional role of interleukin-6 secreted by tumor-associated macrophages in ovarian cancer ascites2011
- Author(s)
  Isobe, A. Sawada, K. Ohyagi, C. Mabuchi, S. Wakabayashi, A. Morishige, K. Kimura, T
- Organizer
  American Association for Cancer Research 102^<nd> Annual Meeting 2011
- Place of Presentation
  Orland, USA
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-22791529
[Presentation] 卵巣がん進展時の腹水中に大量に存在する骨髄由来細胞が果たす役割の解明2011
- Author(s)
  磯部晶
- Organizer
  第63回日本産科婦人科学会学術講演会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-22791529
[Presentation] Analysis of functional role of interleukin-6 secreted by tumor-associated macrophages in ovarian cancer ascites2011
- Author(s)
  Isobe, A.
- Organizer
  American Association for Cancer Research 102nd Annual Meeting 2011
- Place of Presentation
  アメリカ
- Data Source
  KAKENHI-PROJECT-23592447
[Presentation] Analysis of functional role of interleukin-6 secreted by tumor-associated macrophages in ovarian cancer ascites2010
- Author(s)
  Isobe, A. Sawada, K. Ohyagi, C. Mabuchi, S. Kimura, T
- Organizer
  第69回日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22791529
[Presentation] Analysis of functional role of interleukin-6 secreted by tumor-associated macrophage in ovarian cancer ascites.2010
- Author(s)
  Isobe A, Sawada K, Ohyagi C, Mabuchi S, Kimura T.
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22791529
[Presentation] 絨毛膜羊膜炎胎盤におけるInterleukin-6(IL-6)産生細胞の同定とそれを標的とした早産治療の可能性の検討
- Author(s)
  戸田有朱香. 澤田健二郎. 橋本香映. 澤田育子. 磯部　晶. 木瀬康人. 坂田正博. 木村　正
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 低酸素環境下で発現が変動する microRNA の網羅的解析を通じた卵巣癌腹膜播種抑制の分子標的治療の可能性-低酸素刺激で発現低下を示すmiR-199a-3pはc-Metの発現抑制を通じて播種進展を抑制する
- Author(s)
  木瀬康人. 澤田健二郎. 中村幸司. 牧野　弘. 水野智子. 橋本香映. 磯部　晶. 馬淵誠士. 坂田正博. 森重健一郎. 木村　正
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 低酸素環境下で発現が変動する microRNA の網羅的解析を通じた卵巣癌腹膜播種抑制の分子標的治療の可能性-低酸素刺激で発現低下を示すmiR-199a-3pはc-Metの発現抑制を通じて播種進展を抑制する
- Author(s)
  木瀬康人. 澤田健二郎. 中村幸司. 牧野　弘. 水野智子. 橋本香映. 磯部　晶. 馬淵誠士. 坂田正博. 森重健一郎. 木村　正
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-26293360

1. MABUCHI Seiji (00452441)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
2. SAWADA Kenjiro (00452392)

# of Collaborated Projects: 6 results

# of Collaborated Products: 17 results
3. HASHIMOTO Kae (90612078)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
4. KIMURA Tadashi (90240845)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. SAKATA Masahiro (10260639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. Kinose Yasuto

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. Nakamura Koji

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. Yoshimura Akihiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 高橋俊文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 倉智博久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISOBE Aki 磯部 晶

Research Projects

Research Products

Co-Researchers

Why is the treatment of peritoneal dissemination so difficult? Analyses focusing on microRNA and exosome.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigate the adhesion molecules that control the progression of endometriosis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Devoleping a novel anti-angiogenic therapy focused on placental growth factor secreted by ovarian cancer cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of myeloid derived cells which regulates ovarian cancer disseminationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Potential role of mTORC2 as a therapeutic target in epithelial ovarian cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of micro RNAs which affected by tumor microenvironments of ovarian cancer and analysis of a potential as a therapeutic target

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular analysis of placental abruption using in vitro placental model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of functional role of intereukin-6 secreted by tumor-associated macrophage in ovarian cancer ascitesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] IKKβ Regulates VEGF Expression and Is a Potential Therapeutic Target for Ovarian Cancer as an Anti-angiogenic Treatment2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interleukin 6 receptor is an independent prognostic factor and a potential therapeutic target of ovarian cancer.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin α5 expression2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin alpha5 Expression2013

Author(s)

Journal Title

Data Source

[Journal Article] Aldosterone stimulates the proliferation of uterine leiomyoma cells.2010

Author(s)

Journal Title

Data Source

[Presentation] The significance of vascular endothelial growth factor C in the lymphangiogenesis and lymph node metastasis of ovarian cancer2013

Author(s)

Organizer

Place of Presentation

Data Source

ISOBE Aki 磯部晶