Sakata Masahiro 坂田正博

… Alternative Names

SAKATA Masahiro 坂田正博

坂田正浩サカタマサヒロ

坂田正博サカタマサヒロ

Less

Researcher Number	10260639
Affiliation (Current)	2022: 大阪大学, 医学部附属病院, 准教授
Affiliation (based on the past Project Information) *help	2012 – 2014: 大阪大学, 医学部附属病院, 准教授 2008: 大阪大学, 医学部・附属病院, 准教授 2007: 大阪大学, 医学部附属病院, 准教授 2004 – 2006: Osaka University, Hospital, Associate professor, 医学部附属病院, 助教授 2000 – 2003: Osaka University Graduate School of Medicine, Lecturer, 医学系研究科, 講師 … More 2001: Osaka University, School of Medicine, Assistant, 医学部, 助手 1999 – 2001: 大阪大学, 医学系研究科, 助手 1997: 阪大, 医学部, 助手 1994 – 1996: 大阪大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology / Biological Sciences
Keywords	Principal Investigator 胎盤 / グルコーストランスポーター / GLUT / Rho / Oct3 / 4 / hCG / GLUT1 / HIF / Id-1 … More / BMP-4 / trophoblast / ノザンブロット解析 / ウェスタンブロット解析 / グルコース / 糖尿病 / トランスポーター / 卵巣癌 / 抗血管新生療法 / NF-κB シグナル / VEGF / 抗血管新生治療 / 分子標的治療 / NF-κBシグナル / PlGF / 低分子量Gタンパク / RhoGDI / C3トキシン / 受精 / 細胞分裂 / G-protein / blastcyst / morula / ES細胞 / trohoblast / BMP4 / 絨毛細胞 / ES cell … More Except Principal Investigator Rho / エストロゲン / 絨毛細胞 / 卵巣癌 / MAP kinase / ERα / 転写因子 / 浸潤能 / インテグリン / 転写制御 / マイクロアレイ / ラロキシフェン / HUVEC / プロモーターマイクロアレイ / 血管内皮 / シスプラチン / アポトーシス / ERK / JNK / IMT / eNOS / PDGF / atherosclerosis / hypoxia-inducible factor / apoptosis / survival factor / Akt / Rho-kinase / FRET / 細胞分化 / 転写調節機構 / Id-1 / SP-1 / NF-1 / シスプラチン耐性 / タキソール耐性 / マウス卵巣癌モデル / シグナル伝達関連因子 / アポトーシス関連因子 / ERK経路 / Akt経路 / BAD / EGF / PKC(protein kinase C) / CRE(cyclic AMP responsive element) / 選択的エストロゲン受容体調節薬 / siRNA / co-regulator / MCF-7細胞 / ヒト血管平滑筋細胞 / CHIP / Co-activator / Co-repressor / エストロゲン受容体 / co-activator / co-repressor / 乳腺 / 血管平滑筋 / 薬剤反応性 / シグナル伝達 / トランスレーショナルリサーチ / 癌 / タキソール / NFkB / SiRNA / IAPファミリー / アデノウイルス / 子宮筋腫 / メタボリックシンドローム / アンジオテンシン / アルドステロン / アディポネクチン / クルクミン / 移植モデル / ヒト子宮筋腫モデル / メトホルミン / PPARγ / AMPK / mTOR / スピロノラクトン / アンギオテンシン / ELT-3細胞 / ヌードマウス / 高血圧 / GnRHアゴニスト / 耐性 / G1期停止 / DNA損傷 / ヒト卵巣癌 / トランスプラチン / c-Jun / 耐性化 / 燐酸化 / GnRH / 増殖抑制 / GnRH受容体 / MEK inhibitor / SOS / GnRH agonists / Cisplatin / Resistance / Ovarian cancer / G1 arrest / エストロゲンレセプター / NO / パルスドップラー / 閉経 / 脂質 / P-セレクチン / IMT(intima media thickness) / NOS / estradiol / estrogen receptor / P-selection / 繊毛細胞 / 接着因子 / 遊走能 / 上皮成長因子(EGF) / 細胞接着因子 / 上皮成長因子 (EGF) / 細胞浸潤能 / ケモタキシス / 細胞浸潤 / MAPキナーゼ / trophoblast / adhesion molecule / invasion / chemokinesis / integrin / epidermal growth factor (EGF) / gene transcription / 脂質代謝 / Lipoprotein Lipase / マトリツクスメタロプロテイネース / マトリックスメタロプロテイネー / 肥満 / 動脈硬化 / LPL / Estrogen / lipoprotein lipase / ER-α / matrix metalloproteinase / 胞胚 / 絨毛 / 低酸素 / 播種 / hypoxia-inducible factor 1α / ES細胞 / 卵 / グリーンマウス / マトリゲル / blastcyst / chirion / low-oxygen condition / ovarian cancer / dissemination / 血管内皮能 / Brachial artery flow-mediated dilatation / 内皮細胞損傷修復 / 血管内皮機能 / 両側卵巣摘出術 / Survival factor / 血管内皮細胞 / estrogen / raloxifene / vasodilatation / 妊娠中毒症 / 血管攣縮 / 血管内皮障害 / 低分子量G蛋白 / preeclampsia / vasoconstriction / endothelial dysfunction / monomeric G protein Less

Devoleping a novel anti-angiogenic therapy focused on placental growth factor secreted by ovarian cancer cellsPrincipal Investigator
- Principal Investigator
  
  SAKATA Masahiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Uterine leiomyoma and metabolic syndrome-a new therapeutic strategy
- Principal Investigator
  
  TAKEDA Takashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Tohoku University
Analysis of chemo-resistance genes with promoter micro-array in ovarian cancer
- Principal Investigator
  
  OHMICHI Masahide
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka Medical College
選択的エストロゲン受容体調節薬の組織特異的な分子制御機構
- Principal Investigator
  
  大道正英
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka Medical College
  Osaka University
卵巣癌の薬剤耐性化機構の解明と耐性化に関与する分子を標的とする治療法の開発
- Principal Investigator
  
  大道正英
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
絨毛細胞の浸潤能、遊走能制御機構の解明
- Principal Investigator
  
  西尾幸浩
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
A possible role of monomeric GTPase Rho family in the pathogenesis of preeclampsia-New approach to analyse the pathogenesis of preeclampsia-
- Principal Investigator
  
  TAHARA Masahiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
絨毛細胞の分化を制御する転写因子の解析
- Principal Investigator
  
  武田卓
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
FRETを用いたエキソサイトーシス時のリガンド、受容体の細胞内移動の解析
- Principal Investigator
  
  TASAKA Keiichi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Analysis of the interaction between fetal cells and maternal cells in placenta formation using green-mouse embryos
- Principal Investigator
  
  TASAKA Keiichi
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Trophoblast cells differentiation during placenta development is defined by many transcription factors that act as molecular switches to activate or repress specific gene expressionsPrincipal Investigator
- Principal Investigator
  
  SAKATA Masahiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Cardioprotective effect of estrogen and raloxifene
- Principal Investigator
  
  OHMICHI Masahide
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
  Yamagata University
Regulation mechanism of lipid metabolism related gene by estrogen β
- Principal Investigator
  
  TASAKA Keiichi, 山本敏也
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Mechanism of anti-atherosclerotic effect of estrogen
- Principal Investigator
  
  MORISHIGE Kenichiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
Differentiation- dependent regulation of adhesion molecules in trophoblast cells
- Principal Investigator
  
  KURACHI Hirohisa, 西尾幸浩
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Yamagata University
  Osaka University
The expression and function of the small GTPase Rho in the oocyte during fertilization and cell divisionPrincipal Investigator
- Principal Investigator
  
  SAKATA Masahiro
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
The antiproliferative effect of GnRH agonists and the mechanism of the resistance to cisplatin in human ovarian cancer cell line
- Principal Investigator
  
  OHMICHI Masahide
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
胎盤における輸送担体（トランスポーター）の制御に関する研究Principal Investigator
- Principal Investigator
  
  坂田正博
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University
胎盤におけるグルコース輸送担体(グルコーストランスポーター)の制御に関する研究Principal Investigator
- Principal Investigator
  
  坂田正博
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Osaka University

All 2013 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Estradiol and raloxifene induce the proliferation of osteoblasts through G-protein-coupled receptor GPR302013
- Author(s)
  Noda-Seino, H. Sawada, K. Hayakawa, J. Ohyagi-Hara, C. Mabuchi, S. Takahashi, K. Nishio, Y. Sakata, M. Kurachi, H. Kimura, T.
- Journal Title
  
  J Endocrinol Invest
  
  Volume: 36 Pages: 21-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592515
[Journal Article] Antiproliferative effect of adiponectin on rat uterine leiomyoma ELT-3 cells.2011
- Author(s)
  Wakabayashi A, Takeda T, Tsuiji K, Li B, Sakata M, Morishige KI, Yaegashi N, Kimura T.
- Journal Title
  
  Gynecol Endocrinol.
  
  Volume: 27 Pages: 33-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591945
[Journal Article] Aldosterone stimulates the proliferation of uterine leiomyoma2010
- Author(s)
  Isobe A, Takeda T, Wakabayashi A, Tsuiji K, Li B, Sakata M, Yaegashi N, Kimura T
- Journal Title
  
  Gynecol Endocrinol. 26(5)
  
  Pages: 372-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591945
[Journal Article] Aldosterone stimulates the proliferation of uterine leiomyoma2010
- Author(s)
  Isobe A, Takeda T, Wakabayashi A, Tsuiji K, Li B, Sakata M, Yaegashi N, Kimura T.
- Journal Title
  
  Gynecol Endocrinol. (未定, 印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591945
[Journal Article] Antiproliferative effect of adiponectin on rat uterine leiomyoma ELT-3 cells.2010
- Author(s)
  Wakabayashi A, Takeda T, Tsuiji K, Li B, Sakata M, Morishige KI, Yaegashi N, Kimura T.
- Journal Title
  
  Gynecol Endocrinol. May 26(Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591945
[Journal Article] Repressive effect of the phytoestrogen genistein on estradiol-induced uterine leiomyoma cell proliferation2009
- Author(s)
  Miyake A, Takeda T, Isobe A, Wakabayashi A, Nishimoto F, Morishige KI, Sakata M, Kimura T.
- Journal Title
  
  Gynecological Endocrinology. 25
  
  Pages: 403-409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591945
[Journal Article] Metal Transcription Factor-1 is Involved in Hypoxia-Dependent Regulation of Placenta Growth Factor in Trophoblast-Derived Cells.2009
- Author(s)
  Nishimoto F, Sakata M, Minekawa R, Okamoto Y, Miyake A, Isobe A, Yamamoto T, Takeda T, Ishida E, Sawada K, Morishige KI, Kimura T.
- Journal Title
  
  Endocrinology. 150
  
  Pages: 1801-1808
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591945
[Journal Article] Up-regulation of{alpha}5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation.2009
- Author(s)
  Arimoto-Ishida E, Sakata M, Sawada K, Nakayama M, Nishimoto F, Mabuchi S, Takeda T, Yamamoto T, Isobe A, Okamoto Y, Lengyel E, Suehara N, Morishige KI, Kimura T.
- Journal Title
  
  Endocrinology. 150
  
  Pages: 4306-43115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591945
[Journal Article] Dual repressive effect of angiotensin II-type 1 receptor blocker telmisartan on angiotensin II-induced and estradiol-induced uterine leiomyoma cell proliferation2008
- Author(s)
  Isobe, S. Takeda, T. Sakata, M. Miyake, A. Yamamoto, T. Minekawa, R. Nishimoto, F. Okamoto, Y. Walker, L. Kimura, T.
- Journal Title
  
  Hum Reprod 23
  
  Pages: 440-446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591945
[Journal Article] Relationship between metabolic syndrome and uterine leiomyomata : a case-control study2008
- Author(s)
  Takeda, T. Sakata, M. Isobe, A. Miyake, A. Nishimoto, F. Ota, Y. Kamiura, S. Kimura, T.
- Journal Title
  
  Gynecol Obstet Invest 66
  
  Pages: 14-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591945
[Presentation] アディポネクチンは子宮筋腫細胞増殖を抑制する2009
- Author(s)
  若林敦子、武田卓、三宅麻子、磯部晶、石田絵美、西本文人、森重健一郎、坂田正博、木村正
- Organizer
  第61回日本産科婦人科学会
- Place of Presentation
  京都
- Year and Date
  2009-04-03
- Data Source
  KAKENHI-PROJECT-20591945
[Presentation] メタボリックシンドロームは子宮筋腫発症の危険因子か?2008
- Author(s)
  武田卓、坂田正博、三宅麻子、磯部晶、西本文人、太田行信、森重健一郎、上浦祥司、木村正
- Organizer
  第60回日本産科婦人科学会
- Place of Presentation
  横浜
- Year and Date
  2008-04-12
- Data Source
  KAKENHI-PROJECT-20591945
[Presentation] 婦人科癌治療後により生じる骨密度低下に対するリセドロン酸ナトリウム水和物（リセドロネート）の有用性の検討
- Author(s)
  木瀬康人. 澤田健二郎. 戸田有朱香. 笹野智之. 澤田育子. 松本有里. 坂田正博. 木村　正
- Organizer
  第29回日本女性医学学会
- Place of Presentation
  東京
- Year and Date
  2014-11-01 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 絨毛膜羊膜炎胎盤におけるInterleukin-6(IL-6)産生細胞の同定とそれを標的とした早産治療の可能性の検討
- Author(s)
  戸田有朱香. 澤田健二郎. 橋本香映. 澤田育子. 磯部　晶. 木瀬康人. 坂田正博. 木村　正
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-24592515
[Presentation] 低酸素環境下で発現が変動する microRNA の網羅的解析を通じた卵巣癌腹膜播種抑制の分子標的治療の可能性-低酸素刺激で発現低下を示すmiR-199a-3pはc-Metの発現抑制を通じて播種進展を抑制する
- Author(s)
  木瀬康人. 澤田健二郎. 中村幸司. 牧野　弘. 水野智子. 橋本香映. 磯部　晶. 馬淵誠士. 坂田正博. 森重健一郎. 木村　正
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-24592515

1. TASAKA Keiichi (50155058)

# of Collaborated Projects: 12 results

# of Collaborated Products: 0 results
2. OHMICHI Masahide (10283764)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
3. MORISHIGE Kenichiro (90283788)

# of Collaborated Projects: 7 results

# of Collaborated Products: 7 results
4. KURACHI Hirohisa (40153366)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
5. TAHARA Masahiro (00294091)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
6. TAKEDA Takashi (20301260)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
7. 西尾幸浩 (30303952)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
8. YAMAMOTO Toshiya (80283787)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. MINEKAWA RYOKO (10359838)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. NAKAHARA Kenji (80250934)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. TAKAHASHI Kazuhiro (20292427)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. TAKEHARA Mikio (40298766)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. KANEMURA Masanori (40298782)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. HAYAKAWA Jun (80397736)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. HASHOMOTO Namiko (60379253)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. SAWADA Kenjiro (00452392)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
17. MABUCHI Seiji (00452441)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
18. TERAI Yoshito (90278531)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YAMASHITA Yoshiki (50268207)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. TANABE Akiko (70454543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SASAKI Hiroshi (80432491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KAMEGAI Hideki (30204639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ISOBE Aki (60397619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
24. HASHIMOTO Kae (90612078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
25. TEZUKA Naohiro (60261690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 楢原敬二郎 (60368074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 奥田喜代司 (90131325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 築地謙治 (40528155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 池上博雅 (10184409)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 齋藤英和 (90125766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 吉田雅人 (20312738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 築地賢治

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Sakata Masahiro 坂田 正博

SAKATA Masahiro 坂田 正博

坂田 正浩 サカタ マサヒロ

坂田 正博 サカタ マサヒロ

Research Projects

Research Products

Co-Researchers

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Trophoblast cells differentiation during placenta development is defined by many transcription factors that act as molecular switches to activate or repress specific gene expressionsPrincipal Investigator

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Sakata Masahiro 坂田正博

SAKATA Masahiro 坂田正博

坂田正浩サカタマサヒロ

坂田正博サカタマサヒロ