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NAKAHARA Kenji  中原 健次

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… Alternative Names

中原 健次  ナカハラ ケンジ

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Researcher Number 80250934
Affiliation (based on the past Project Information) *help 2007: Yamagata University, Faculty of Medicine, Associate Professor
1999 – 2006: Dep Ob-Gyn, School of Medicine, Yamagata University, Assist. Professor, 医学部, 講師
2004: 国立大学法人山形大学, 医学部, 講師
1996 – 1998: Yamagata Univ.OB/GYN Assistant, 医学部, 助手
1994: 山形大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Obstetrics and gynecology
Except Principal Investigator
Obstetrics and gynecology / Obstetrics and gynecology / Biological Sciences
Keywords
Principal Investigator
顆粒膜細胞 / 卵巣 / アポトーシス / 卵胞閉鎖 / APOPTOSIS / OVARY / ATRESIA OF FOLLICLE / GRANULOSA CELL / INTRACELLULAR SIGNAL TRANSDUCTION / Steroidgenesis … More / NO / growth hormone / 卵胞発育 / マクロファージ / マウス / 細胞内シグナル伝達 / 卵の質 / シグナル伝達 / 卵胞 … More
Except Principal Investigator
エストロゲン受容体 / エストロゲン / 上皮成長因子(EGF) / 転写制御 / 卵胞 / CD44 / MAPキナーゼ / 細胞周期 / テロメラーゼ / アポトーシス / cyclin D1 / シスプラチン耐性 / タキソール耐性 / マウス卵巣癌モデル / シグナル伝達関連因子 / アポトーシス関連因子 / ERK経路 / Akt経路 / BAD / インスリン様増殖因子(IGF)-1 / 欠失変異 / シグナル伝達 / 核内分布 / GFPキメラ蛋白 / 変異遺伝子 / AF-2ドメイン / 蛍光顕微鏡 / 共焦点レーザー顕微鏡 / 受精 / 胚発育 / 卵管特異糖蛋白 / カルシウム オスシレーション / 顕微受精 / カルシウムオスシレーション / 顕微授精 / 透明帯 / 卵管分泌性糖蛋白 / 卵の糖代謝 / steroidogenesis / 細胞内カルシウム / アポト-ジス / 卵子 / 精子 / 卵管因子 / 子宮筋gap junction / fertilization / embryo / oviduct glycoprotein / Ca-oscillation / microinsemination / 顆粒膜細胞 / steroid産生 / アポトージス / 卵透明帯 / Ovarian follicle / Granulosa Cell / Steroidogenesis / Apoptosis / 繊毛細胞 / 接着因子 / 浸潤能 / 遊走能 / インテグリン / 絨毛細胞 / 細胞接着因子 / 上皮成長因子 (EGF) / 細胞浸潤能 / ケモタキシス / 細胞浸潤 / 転写因子 / trophoblast / adhesion molecule / invasion / chemokinesis / integrin / epidermal growth factor (EGF) / gene transcription / 卵の質 / 酸化ストレス / 8-OHdG / グルタチオンリダクターゼ / 卵 / 胚 / 凍結 / ヒアルロン酸 / quality of oocyte / oxidative stress / cell cycle / 8 OhdG / glutathione reductase / 動脈硬化 / リン酸化 / MAPキナーゼ経路 / 選択的エストロゲン受容体修飾薬 / 乳がん / ラロキシフェン / 血管平滑筋 / PI3K / Akt / NFκB経路 / nongenomicな作用 / 増殖 / サイクリンD1 / Rb蛋白 / プロモーター / p38経路 / 細胞内情報伝達 / estrogen receptor / atherosclerosis / apoptosis / phosphorylation / MAP kinase pathway / selective estrogen receptor modulator / mammary carcinoma / 卵巣癌 / 分子標的治療 / EGF受容体 / シグナル伝達経路 / 抗癌剤 / EGF受容体(EGFR) / DNA損傷 / ovanan cancer / molecular tareeted therapy / EGF receptor / sienal transduction / anti cancer drug Less
  • Research Projects

    (12 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (27 People)
  •  Study for the development of molecular therapy targeting the signal transduction pathway through epidermal growth factor receptor

    • Principal Investigator
      KURACHI Hirohisa
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  卵巣癌の薬剤耐性化機構の解明と耐性化に関与する分子を標的とする治療法の開発

    • Principal Investigator
      OUMICHI Masahide
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  リガンド依存性・非依存性のエストロゲン受容体活性化と核内分布変化を可視化する試み

    • Principal Investigator
      倉智 博久
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  Antiatherogenic action of estrogen through inhibition of pathological proliferation in vascular smooth muscle sells

    • Principal Investigator
      KURACHI Hirohisa
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  EVALUATION OF OOCYTES QUALITY THOROUGH ANALYSIS OF APOPTOTIC SIGNAL TRANSDUCTION IN FOLLICLES.Principal Investigator

    • Principal Investigator
      NAKAHARA Kenji
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      YAMAGATA UNIVERSITY
  •  Study of factors regulating the development of follicles, oocytes and embryos

    • Principal Investigator
      SAITO Hidekazu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  ELUCIDATION OF MAKING ATRETIC FOLLICLES VIA APOPTOSIS AND MECHANISM OF INTRACELLULAR APOPTOTIC SIGNALSPrincipal Investigator

    • Principal Investigator
      NAKAHARA Kenji
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      YAMAGATA UNIVERSITY
  •  Differentiation- dependent regulation of adhesion molecules in trophoblast cells

    • Principal Investigator
      KURACHI Hirohisa, 西尾 幸浩
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
      Osaka University
  •  Studies on the regulatory mechanism of interaction between the development of ovulatry follicle and ovum in the ovary.

    • Principal Investigator
      HIROI Masahiko
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      YAMAGATA UNIVERSITY
  •  卵胞発育・閉鎖機構における免疫機序および黄体退縮機序の解明Principal Investigator

    • Principal Investigator
      中原 健次
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  亜鉛及び銅イオン動態がステロイドホルモン・レセプター動態に及ぼす影響Principal Investigator

    • Principal Investigator
      中原 健次
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University
  •  Mechanism of fertilization and embryo development

    • Principal Investigator
      HIROI Masahiko
    • Project Period (FY)
      1993 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Yamagata University

All 2006

All Journal Article

  • [Journal Article] Clinical outcome and risk factors for recurrence in borderline ovarian tumours.2006

    • Author(s)
      Yokoyama Y, Moriya T, Takano T, Shoji T, Takahasi O, Nakahara K, Yamada H, Yaegashi N, Okamura K, Izutsu T, Sugiyama T, Tanaka T, Kurachi H, Sato A, Tase T, Mizunuma H.
    • Journal Title

      Br J Cancer 94(11)

      Pages: 1586-1591

    • Data Source
      KAKENHI-PROJECT-17390445
  • [Journal Article] Usefulness of intraovarian artery pulsatility and resistance indices measurement on the day of follicle aspiration for the assessment of oocyte quality.2006

    • Author(s)
      Du B, Takahashi K, Ishida GM, Nakahara K, Saito H, Kurachi H.
    • Journal Title

      Fertil Steril 85(2)

      Pages: 366-370

    • Data Source
      KAKENHI-PROJECT-17390445
  • 1.  KURACHI Hirohisa (40153366)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 2 results
  • 2.  SAITO Hidekazu (90125766)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  TAKAHASHI Kazuhiro (20292427)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 4.  SAITO Takakazu (00272071)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  OUMICHI Masahide (10283764)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  TANAKA Eiichi (20322000)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  HIROI Masahiko (60018364)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  SAKATA Masahiro (10260639)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  TEZUKA Naohiro (60261690)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  TAKAHASHI Toshifumi (20302292)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  KAWACHIYA Satoshi (30322001)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  ARAKI Yoshihiko (70250933)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  HIRAYAMA Toshio (60238392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  ITOH Mariko (40292429)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  YAMAMOTO Toshiya (80283787)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MORISHIGE Kenichirou (90283788)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  TUTUMI Seiji (50323168)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  ABE Akiko (30359567)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  HAYASAKA Tadashi (10375339)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  田坂 慶一 (50155058)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  五十嵐 秀樹 (80333970)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  小宮 雄一 (70234888)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  川越 慎之助 (10018880)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  太田 信彦 (40301072)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  西尾 幸浩 (30303952)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  清野 朝史 (00311580)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  吉田 雅人 (20312738)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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