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Hyodo Ichinosuke  兵頭 一之介

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… Alternative Names

HYODO ICHINOSUKE  兵頭 一之介

HYODO Ichinosuke  兵頭 一之介

兵頭 一之介  ヒョウドウ イチノスケ

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Researcher Number 60416469
Affiliation (Current) 2025: 独立行政法人国立病院機構四国がんセンター(臨床研究センター), その他部局等, 医師
Affiliation (based on the past Project Information) *help 2020: 独立行政法人国立病院機構四国がんセンター(臨床研究センター), その他部局等, 医師
2018 – 2019: 筑波大学, 医学医療系, 教授
2011 – 2016: 筑波大学, 医学医療系, 教授
2010: 筑波大学, 大学院・人間総合科学研究科, 教授
2007 – 2008: 筑波大学, 大学院・人間総合科学研究科, 教授
2005: University of Tsukuba, Graduate school, professor, 大学院, 教授
Review Section/Research Field
Principal Investigator
Applied pharmacology / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Gastroenterology / Applied pharmacology / Digestive surgery / Laboratory medicine
Keywords
Principal Investigator
p53 / MDM2 / p53腫瘍抑制遺伝子 / TP53変異細胞 / iASPP / ΔNp73 / p73活性化 / がん / p73 / SIRT1 / siRNA / 胃癌 … More
Except Principal Investigator
… More 腫瘍融解ウイルス / 個別化医療 / 糖鎖分子マーカー / レクチン / 胆道系悪性腫瘍 / opioid receptor / pharmacogenetics / morphine / UGT2B7 / オピオイド受容体 / 遺伝子多型 / モルヒネ / ソラフェニブ / ワクシニアウイルス / 癌幹細胞 / 肝細胞癌 / 胆道癌 / 遺伝子化学療法 / UPRT / 5-fluorouracil / サイクロフォスファマイド / アデノウイルス / 遺伝子治療 Less
  • Research Projects

    (8 results)
  • Research Products

    (23 results)
  • Co-Researchers

    (21 People)
  •  A research for gastrointestinal cancer treatment targeting EGFR-p53 pathwayPrincipal Investigator

    • Principal Investigator
      HYODO ICHINOSUKE
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      National Hospital Organization Shikoku Cancer Center
      University of Tsukuba
  •  A basic research of p73 activation as a novel treatment for p53-mutant type cancerPrincipal Investigator

    • Principal Investigator
      HYODO Ichinosuke
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      University of Tsukuba
  •  Evaluation of cytotoxic effects of oncolytic vaccinia virus on cancer stem cells of liver cancers.

    • Principal Investigator
      Abei Masato
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tsukuba
  •  Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cellsPrincipal Investigator

    • Principal Investigator
      HYODO Ichinosuke
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      University of Tsukuba
  •  Evaluation of efficacy and safety of gene-chemotherapy for biliary cancers using oncolytic adenovirus armed with UPRT

    • Principal Investigator
      ABEI Masato
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      University of Tsukuba
  •  胆道系悪性腫瘍の個別化医療に向けたレクチンアレイによる糖鎖分子マーカーの探索

    • Principal Investigator
      正田 純一
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Laboratory medicine
    • Research Institution
      University of Tsukuba
  •  肝内結石症からの胆道発癌プロセスと糖鎖分子マーカー活用による肝内胆管癌の早期診断

    • Principal Investigator
      遠藤 隆志
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      University of Tsukuba
  •  Effects of morphine-related genotypes on the individualized morphine treatment in cancer patients

    • Principal Investigator
      OHASHI Kyoichi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      Oita University
      Hamamatsu University School of Medicine

All 2021 2015 2014 2013 2012 2011 2010 2005

All Journal Article Presentation

  • [Journal Article] MDM4 as a Prognostic Factor for Patients With Gastric Cancer With Low Expression of p53.2021

    • Author(s)
      Zhang X, Yamamoto Y, Wang X, Sato M, Imanishi M, Sugaya A, Hirose M, Endo S, Moriwaki T, Yamato K, Hyodo I
    • Journal Title

      Anticancer Res.

      Volume: 41 Issue: 3 Pages: 1475-1483

    • DOI

      10.21873/anticanres.14906

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07288
  • [Journal Article] Enhanced G1 arrest and apoptosis via MDM4/MDM2 double knockdown and MEK inhibition in wild-type TP53 colon and gastric cancer cells with aberrant KRAS signaling2021

    • Author(s)
      Wang X, Yamamoto Y, Imanishi M, Zhang X, Sato M, Sugaya A, Hirose M, Endo S, Natori Y, Moriwaki T, Yamato K, Hyodo I
    • Journal Title

      Oncology Letters

      Volume: -

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07288
  • [Journal Article] Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib.2015

    • Author(s)
      Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shiota, Taro Yamashuita, Ichinosuke Hyodo, Yukio Nakamura.
    • Journal Title

      BMC Cancer

      Volume: 15 Issue: 1 Pages: 260-260

    • DOI

      10.1186/s12885-015-1297-7

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25460975
  • [Journal Article] Cyclophosphamide enhances antitumor efficacy of oncolytic adenovirus expressing uracil phosphoribosyltransferase (UPRT) in immunocompetent Syrian hamsters2013

    • Author(s)
      Hasegawa N, Abei M, Yokoyama KK, Fukuda K, Seo E, Kawashima R, Nakano Y, Yamada T, Nakade K, Hamada H, Obata Y, Hyodo I
    • Journal Title

      Int. J.Cancer

      Volume: PMID: 23444104(印刷中) Issue: 6 Pages: 1479-1488

    • DOI

      10.1002/ijc.28132

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590755, KAKENHI-PROJECT-23501277
  • [Journal Article] EpCAM- and EGFR- targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus2011

    • Author(s)
      Kawashima R, Abei M, Fukuda K, Nakamura K, Murata T, Wakayama M, Seo E, Hasegawa N, Mizuguchi H, Obata Y, Hyodo I, Hamada H, Yokoyama KK
    • Journal Title

      Int. J. Cancer

      Volume: 129巻 Pages: 1244-1253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590755
  • [Journal Article] Potent in vitroand in vivo anti-tumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells2011

    • Author(s)
      Endo S, Yamato K, Hirai S, MoriwakiT, Fukuda K, Suzuki H, Abei M, Nakagawa I, Hyodo I.
    • Journal Title

      Cancer Sci

      Volume: 102(3) Pages: 605-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590497
  • [Journal Article] Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.2011

    • Author(s)
      Endo S, Hyodo I, et al.
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 605-613

    • NAID

      10029291334

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590497
  • [Journal Article] Effect of opioid- μ receptor genotype on clinical effect of morphine2005

    • Author(s)
      Tateishi M, Uchida S, Eguchi K, Hyodo I, Oashi K
    • Journal Title

      Jap J Clin Pharmacol Ther 36 Suppl

      Pages: 185-185

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590436
  • [Journal Article] モルヒネの薬効におけるμ受容体遺伝子多型2005

    • Author(s)
      立石正登, 内田信也, 江口研二, 兵頭一之介, 大橋京一
    • Journal Title

      臨床薬理 36Suppl

      Pages: 185-185

    • Data Source
      KAKENHI-PROJECT-16590436
  • [Journal Article] モルヒネの薬効におけるμ受容体遺伝子多型2005

    • Author(s)
      立石正登, 内田信也, 江口研二, 兵頭一之介, 大橋京一
    • Journal Title

      臨床薬理 36 Suppl

      Pages: 185-185

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590436
  • [Presentation] Identification of A Hepatocellular Carcinoma Cell Line, Li-7, Capable of Monitoring The Differentiation of CD13(+)CD166(-) Cancer Stem Cells And Effects of Sorafenib.2015

    • Author(s)
      Takeshi Yamada, Masato Abei M, Inaho Danjoh, Ichinosuke Hyodo, Yukio Nakamura.
    • Organizer
      米国癌学会(AACR)2015
    • Place of Presentation
      米国フィラデルフィア,ペンシルバニアコンベンションセンター
    • Year and Date
      2015-04-20
    • Data Source
      KAKENHI-PROJECT-25460975
  • [Presentation] Identification of A Hepatocellular Carcinoma Cell Line, Ki-7, Capable of Monitoring the Differentiation of CD13(+)CD166(-) Cancer Stem Cells and Effects of Sorafenib.2015

    • Author(s)
      Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shiota, Taro Yamashita, Ichinosuke Hyodo, Yukio Nakamura.
    • Organizer
      米国癌学会(AACR)2015
    • Place of Presentation
      米国フィラデルフィア,ペンシルバニアコンベンションセンター
    • Year and Date
      2015-04-20
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460975
  • [Presentation] A hepatocellular carcinoma (HCC) line able to monitor cancer stem cells differentiation and the effects of drugs targeting CSC.2014

    • Author(s)
      Takeshi Yamada, Masato Abei M, Inaho Danjoh, Ichinosuke Hyodo, Yukio Nakamura.
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25
    • Data Source
      KAKENHI-PROJECT-25460975
  • [Presentation] UPRT遺伝子武装腫瘍融解アデノウイルスを用いた膵癌の遺伝子化学療法の基礎的検討 (2): シクロフォスファミドによる免疫抑制との併用効果2013

    • Author(s)
      長谷川直之,安部井誠人,福田邦明,兵頭一之介
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      かごしま県民交流センター,鹿児島
    • Year and Date
      2013-03-21
    • Data Source
      KAKENHI-PROJECT-22590755
  • [Presentation] UPRT遺伝子武装腫瘍融解アデノウイルスを用いた膵癌の遺伝子化学療法の基礎的検討 (1):免疫適格同種ハムスター膵癌モデルにおける有効性と安全性の評価2013

    • Author(s)
      長谷川直之,安部井誠人,福田邦明,兵頭一之介
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      かごしま県民交流センター,鹿児島
    • Year and Date
      2013-03-21
    • Data Source
      KAKENHI-PROJECT-22590755
  • [Presentation] 胃癌におけるMDM2及びp53蛋白発現の免疫組織学的検討2012

    • Author(s)
      兵頭 一之介
    • Organizer
      日本消化器病学会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Data Source
      KAKENHI-PROJECT-22590497
  • [Presentation] Efficacy and safety of oncolytic adenovirus combined with UPRT/5-FU suicide gene system: Evaluation in syngenic pancreas cancer model in immunocompetent,adenovirus-permissive Syrian hamsters.2012

    • Author(s)
      Hasegawa N, Abei M, Fukuda K,Kawashima R,Seo E, WakayamaM, Hamada H, Yokoyama KK, Obata Y, Hyodo I
    • Organizer
      第18回日本遺伝子治療学会総会
    • Place of Presentation
      熊本テルサ,熊本
    • Year and Date
      2012-06-29
    • Data Source
      KAKENHI-PROJECT-22590755
  • [Presentation] Efficacy and safety of gene-chemo therapy using oncolytic adenovirus expressing uracil phosphoribosyl transferase (UPRT) followed by 5-fluorouracil administration in syngenic pancreatic and biliary cancers in immunocompetent adenoviruspermissive Syrian ha2012

    • Author(s)
      Hasegawa N, Abei M, Fukuda K,SeoE, Wakayama M, KawashimaR, Murata T, Hamada H, YokoyamaKK, Obata Y, Hyodo I.
    • Organizer
      第15回米国遺伝子・細胞治療学会
    • Place of Presentation
      ペンシルベニア・コンベンションセンター,フィラデルフィア,アメリカ合衆国
    • Year and Date
      2012-05-17
    • Data Source
      KAKENHI-PROJECT-22590755
  • [Presentation] Targeted and armed oncolytic vaccinia virus JX-594 for treating advanced liver cancers: Recent advances in global clinical trials and our clinical trial plan in Japan.2012

    • Author(s)
      Abei, M, Hyodo I, Kirn DH
    • Organizer
      第18回日本遺伝子治療学会総会
    • Place of Presentation
      熊本テルサ,熊本
    • Year and Date
      2012-06-30
    • Data Source
      KAKENHI-PROJECT-22590755
  • [Presentation] Immunosuppression enhances the Efficacy of oncolytic adenovirus-mediated uracil phosphoribosyl Transferase (UPRT)/ 5-fluorouracil suicide gene therapy in immunocompetent adenoviruspermissive Syrian hamsters2012

    • Author(s)
      Hasegawa N, Abei M, Fukuda K,Seo E,Wakayama M, Kawashima R, Hamada H, Yokoyama KK, Obata Y, Hyodo I
    • Organizer
      2012国際癌遺伝子・細胞治療学会(ISCGT)
    • Place of Presentation
      フラマホテル,シンガポール
    • Year and Date
      2012-10-04
    • Data Source
      KAKENHI-PROJECT-22590755
  • [Presentation] The anti-tumor effect of MDM2 antagonist nutlin-3 in gastric cancer cell in vitro and in vivo2010

    • Author(s)
      Endo S, Suzuki H, Hirai S, Hyodo I, Yamato K
    • Organizer
      第101回米国癌学会第101回米国癌学会
    • Place of Presentation
      ワシントン,米国
    • Year and Date
      2010-04-20
    • Data Source
      KAKENHI-PROJECT-22590497
  • [Presentation] EpCAM and EGFR-targeted selective gene therapy for biliary cancers using Z33-fiber modified adenovirus.2010

    • Author(s)
      Abei M, Kawashima R, Fukuda K, Nakamura K, Murata T,Yokoyama KK,Hamada H, Hyodo I
    • Organizer
      第16回日本遺伝子治療学会総会
    • Place of Presentation
      栃木県総合文化センター,宇都宮
    • Year and Date
      2010-07-02
    • Data Source
      KAKENHI-PROJECT-22590755
  • [Presentation] ヒト胃癌細胞株におけるMDM2阻害剤nutlin-3の抗腫瘍効果について2010

    • Author(s)
      遠藤慎治,鈴木英雄,平井祥子,兵頭一之介,大和建嗣
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場,大阪市
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-22590497
  • 1.  ABEI Masato (20261802)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  正田 純一 (90241827)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  大河内 信弘 (40213673)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  平林 淳 (40156691)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  山本 祥之 (00649288)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  SUZUKI Hideo (00400672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  FUKUDA Kuniaki (50447257)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 8.  HAMADA Hirofumi (00189614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 9.  NAGATA KYOSUKE (40180492)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  YAMASHITA TATSUROU (90377432)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  OHASHI Kyoichi (20137714)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 12.  EGUCHI Kenji (30349336)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 13.  UCHIDA Shinya (80372522)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 14.  KOTEGAWA Tsutomu (20264343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  遠藤 隆志 (60223690)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  中村 幸夫 (60231479)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 17.  遠藤 慎治 (40625919)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  大和 建嗣 (50174751)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  橋本 久邦 (10009558)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  YAMASHITA Taro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  阿部井 誠人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 14 results

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