SHIMAMURA MUNEHISA 島村宗尚

… Alternative Names

Munehisa Shimamura 島村宗尚

SHIMAMURA Munehisa 島村宗尚

島村宗尚シマムラムネヒサ

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Researcher Number	60422317
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 招へい教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 寄附講座教授 2016 – 2021: 大阪大学, 医学系研究科, 寄附講座准教授 2015: 大阪大学, 医学(系)研究科(研究院), 寄附講座准教授 2013: 大阪大学, 連合小児発達学研究科, 寄附講座准教授 2012: 大阪大学, その他の研究科, 准教授 … More 2012: 大阪大学, その他研究科, 准教授 2011: 大阪大学, 医学系研究科, 寄附講座准教授 2010 – 2011: 大阪大学, 連合小児発達学研究科, 寄附講座准教授 2010: 大阪大学, 医学系研究科, 寄付講座准教授 2007: 東大, 医学部附属病院 Less
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related / Neurosurgery / Cerebral neurosurgery Except Principal Investigator Basic Section 52010:General internal medicine-related / Basic Section 56020:Orthopedics-related / Basic Section 53020:Cardiology-related / Neurosurgery / General internal medicine (including Psychosomatic medicine)
Keywords	Principal Investigator 炎症 / 脳梗塞 / 神経再生 / Toll-like receptor / FAP / 血栓回収療法 / 脳血管障害 / 部分再開通 / RANKLペプチド / LGR … More / LGR4 / 血液脳関門 / 神経細胞死 / 脳血管障害学 / 骨髄由来免疫抑制細胞 / OPG / RANK / RANKL / ミクログリア / マクロファージ / 血管傷害モデル / 血管リモデリング / 血管障害モデル / 頭蓋内脳動脈 / マウス / 脂質異常症 / 脳血管形成術 / リモデリング / 脳血管内外科学 … More Except Principal Investigator 老化細胞 / 慢性炎症 / ワクチン / RANKL / 炎症 / NF-κB経路 / 骨粗鬆症 / 炎症性骨粗鬆症 / 閉経後骨粗鬆症 / NF-κB / MHP1 / エンドセリン受容体 / 動脈硬化 / 翻訳後修飾 / エンドセリン / アラーミン / 抗体 / 免疫　老化 / 癌 / 糖鎖 / 老化 / 免疫 / 複合糖質ワクチン / RANKLペプチド / ミクログリア / マクロファージ / Toll-like receptor / 合成ペプチド / RANK / 脳梗塞 / 糖尿病 / インターロイキン-6 / 周辺症状 / βアミロイド / 血管 / アルツハイマー病 / 認知機能 / 脳血管 / サイトカイン / 血液脳関門 / ベータ・アミロイド Less

脳梗塞後炎症免疫機構および神経再生におけるFAPの機能解明と治療応用への検討Principal Investigator
- Principal Investigator
  
  島村宗尚
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka University
Development of a novel osteoporosis treatment using Microglia-Healing Peptides 1 (MHP1)
- Principal Investigator
  
  蛯名耕介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Osaka University
動脈硬化発症プロセスにおける一酸化窒素修飾がもたらすエンドセリン受容体機能の検討
- Principal Investigator
  
  林宏樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Therapeutic vaccine for senolysis
- Principal Investigator
  
  Nakagami Hironori
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Osaka University
Pathophysiological analysis and development of therapy in partial reperfusion in ischemic strokePrincipal Investigator
- Principal Investigator
  
  Shimamura Munehisa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Osaka University
Investigation of vaccines using glycolipid antigens for anti-aging
- Principal Investigator
  
  Iwabu Yuka
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Osaka University
Development of novel immunotherapy for chronic inflammatory diseases
- Principal Investigator
  
  Nakagami Hironori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Osaka University
Clarification of roles of myeloid-derived suppressor cells on the regulation of post-ischemic inflammationPrincipal Investigator
- Principal Investigator
  
  Shimamura Munehisa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Osaka University
Development of a novel anti-inflammatory peptide targetting RANK signal in ischemic stroke
- Principal Investigator
  
  Kurinami Hitomi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Osaka University
Development of novel therapeutic approaches in ischemic stroke targeting regulation of inflammation through RANKL/RANK signalPrincipal Investigator
- Principal Investigator
  
  Munehisa Shimamura
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Osaka University
Development of a novel therapy for Alzheimer's disease based on vascular modification
- Principal Investigator
  
  MORISHITA Ryuichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Osaka University
Ctarification of pathophysiology of remodeling after intracranial artery inJury model in mice in dystipidemiaPrincipal Investigator
- Principal Investigator
  
  MUNEHISA Shimamura
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Osaka University
頭蓋内脳動脈における血管形成術後の再狭窄の病態解明と治療法の開発Principal Investigator
- Principal Investigator
  
  島村宗尚
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  The University of Tokyo

All 2021 2020 2019 2018 2016 2015 2014 2013 2012 2011 2010

All Journal Article Presentation Patent

[Journal Article] The CD153 vaccine is a senotherapeutic option for preventing the accumulation of senescent T cells in mice2020
- Author(s)
  Yoshida S, Nakagami H, Hayashi H, Ikeda Y, Sun J, Tenma A, Tomioka H, Kawano T, Shimamura M, Morishita R, Rakugi H.
- Journal Title
  
  Nat Commun
  
  Volume: 11(1) Issue: 1 Pages: 2482-2482
- DOI
  10.1038/s41467-020-16347-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02730
[Journal Article] Temporal and spatial profile of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in ischemic stroke in mice2019
- Author(s)
  Kawano T, Shimamura M, Nakagami H, Kanki H, Sasaki T, Mochizuki H.
- Journal Title
  
  PLOS ONE
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10720
[Journal Article] Therapeutic Vaccine Against S100A9 (S100 Calcium-Binding Protein A9) Inhibits Thrombosis Without Increasing the Risk of Bleeding in Ischemic Stroke in Mice2018
- Author(s)
  Kawano T, Shimamura M, Nakagami H, Iso T, Koriyama H, Takeda S, Baba K, Sasaki T, Sakaguchi M, Morishita R, Mochizuki H.
- Journal Title
  
  Hypertension
  
  Volume: 72(6) Issue: 6 Pages: 1355-1364
- DOI
  10.1161/hypertensionaha.118.11316
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09568, KAKENHI-PROJECT-18H02730
[Journal Article] A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke2016
- Author(s)
  Kurinami H, Shimamura M, Nakagami H, Shimizu H, Koriyama H, Kawano T, Wakayama K, Mochizuki H, Rakugi H, Morishita R
- Journal Title
  
  Sci Rep
  
  Volume: 29 Issue: 1
- DOI
  10.1038/srep38062
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K10300
[Journal Article] Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model2013
- Author(s)
  Munehisa Shimamura
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: 33 Issue: 8 Pages: 1153-1159
- DOI
  10.1038/jcbfm.2013.62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390145, KAKENHI-PROJECT-22390159, KAKENHI-PROJECT-24592063, KAKENHI-PROJECT-24659392, KAKENHI-PROJECT-25670390
[Journal Article] HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function2012
- Author(s)
  Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, Sato N, Koriyama H, Mori M, Gerardo Araujo R, Maeda A, Morishita R, Tamai K, Kaneda Y
- Journal Title
  
  FASEB J
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390145
[Journal Article] Role of Central Nervous System Periostin in Cerebral Ischemia2012
- Author(s)
  Munehisa Shimamura
- Journal Title
  
  Stroke
  
  Volume: 43 Issue: 4 Pages: 1108-1114
- DOI
  10.1161/strokeaha.111.636662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390145, KAKENHI-PROJECT-23390187, KAKENHI-PROJECT-24659349
[Journal Article] Role of Central Nervous System Periostin in Cerebral Ischemia2012
- Author(s)
  Shimamura M, Taniyama Y, Katsuragi N, Koibuchi N, Kyutoku M, Sato N, Allahtavakoli M, Wakayama K, Nakagami H, Morishita R
- Journal Title
  
  Stroke
  
  Volume: 43 Pages: 1108-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390145
[Journal Article] Experimental and clinical application of plasmid DNA in the field of central nervous diseases2011
- Author(s)
  Shimamura M, Sato N, Morishita R
- Journal Title
  
  Curr Gene Ther
  
  Volume: 11(6) Pages: 491-500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390145
[Journal Article] Reduction of brain A. by fluvastatin, an HMG-CoA reductase inhibitor, through increase in degradation of APP-CTFs and A. clearance.2010
- Author(s)
  Mitsuru Shinohara, Naoyuki Sato, Hitomi Kurinami, Daisuke Takeuchi, Shuko Takeda, Munehisa Shimamura, Toshihide Yamashita, Yasuo Uchiyama, Hiromi Rakugi, and Ryuichi Morishita
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 285 Pages: 22091-22102
- Data Source
  KAKENHI-PROJECT-22390145
[Journal Article] Reduction of Brain β-amyloid (Aβ) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, thrpugh increase in degradation of amyloid precursor protein C-terminal fragnents (APP-CTFs) and Aβ clearance2010
- Author(s)
  Shinohara M, Sato N, Kurinami H, Takeuchi D, Takeda S, Shimamura M, Yamashita T, Uchiyama Y, Rakugi H, Morishita R.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 285 Pages: 22091-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390145
[Patent] 炎症性サイトカイン分泌抑制活性を有するオリゴペプチド2015
- Inventor(s)
  栗波仁美、島村宗尚　他
- Industrial Property Rights Holder
  栗波仁美、島村宗尚　他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-102502
- Filing Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K10300
[Patent] 梗塞性疾患の予防または治療用医薬2014
- Inventor(s)
  島村宗尚
- Industrial Property Rights Holder
  島村宗尚
- Industrial Property Rights Type
  特許
- Filing Date
  2014
- Data Source
  KAKENHI-PROJECT-25462214
[Presentation] 部分再開通における脳梗塞の病態解析2021
- Author(s)
  島村宗尚
- Organizer
  第21回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-20K09388
[Presentation] 脳梗塞における部分再開通の病態解析2021
- Author(s)
  島村宗尚
- Organizer
  第11回日本脳血管・認知症学会総会
- Data Source
  KAKENHI-PROJECT-20K09388
[Presentation] 脳梗塞におけるPMN-MDSCの経時的および空間的発現解析2019
- Author(s)
  河野友裕、島村宗尚　他
- Organizer
  第44回日本脳卒中学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10720
[Presentation] A novel partial anosit-like RANKL peptide inhibiting TLR-induced inflammation in ischemic brain2016
- Author(s)
  島村宗尚
- Organizer
  日本神経学会
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-15K10300
[Presentation] 脳梗塞後の炎症を制御するRANKL-RANKシグナルについての検討2015
- Author(s)
  島村宗尚
- Organizer
  第21回国際個別化医療学会
- Place of Presentation
  大阪
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-25462214
[Presentation] RANKL-RANK is a novel anti-inflammatory signaling system in ischemic brain2015
- Author(s)
  島村宗尚
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  新潟
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-25462214
[Presentation] RANK シグナルをターゲットにした脳梗塞における新規治療法についての検討2015
- Author(s)
  島村宗尚
- Organizer
  第6回日本脳血管・認知症学会学術大会
- Place of Presentation
  東京
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-25462214
[Presentation] Role of OPG/RANKL/RANK System in Ischemic Brain in Mice.2014
- Author(s)
  Munehisa Shimamura
- Organizer
  International Stroke Meeting 2014
- Place of Presentation
  San Diego（アメリカ）
- Data Source
  KAKENHI-PROJECT-25462214
[Presentation] Novel Mouse Model of lntracranial Artery lnjury that lnduces Delayed Neointimal Hyperplasia and Long-lasting Perivascular lnflammmation.2012
- Author(s)
  島村宗尚、中神啓徳、三宅隆、志水秀郎、大窄マリアナ今日美、中神太志、久徳真梨子、郡山弘、森下竜一
- Organizer
  第76回日本循環器学会総会
- Place of Presentation
  福岡
- Year and Date
  2012-03-18
- Data Source
  KAKENHI-PROJECT-22791341
[Presentation] 脳血管形成術後再狭窄の病態解明を目的とした脳血管傷害モデルの開発.2011
- Author(s)
  島村宗尚、中神啓徳、若山幸示、三宅隆、久徳真理子、中神太志、大窄マリアナ今日美、郡山弘、森下竜一
- Organizer
  アンチエイジングフェスタ2011
- Place of Presentation
  大阪
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-22791341
[Presentation] スタチンによるアルツハイマー病予防効果の機序の解明2010
- Author(s)
  里直行、篠原充、島村宗尚、武田朱公、楽木宏実、森下竜一
- Organizer
  第18回日本血管生物医学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2010-12-01
- Data Source
  KAKENHI-PROJECT-22390145

1. Nakagami Hironori (20325369)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
2. 林宏樹 (20813364)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KURINAMI HITOMI (10638555)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. MORISHITA Ryuichi (40291439)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. SATO Naoyuki (70372612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. NAITO Kozue (70373397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Iwabu Yuka (30738266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 樂木宏実 (20252679)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 張今陽 (90869124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 蛯名耕介 (70612076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ISO Tatsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 樂木宏美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMAMURA MUNEHISA 島村 宗尚

Munehisa Shimamura 島村 宗尚

SHIMAMURA Munehisa 島村 宗尚

島村 宗尚 シマムラ ムネヒサ

Research Projects

Research Products

Co-Researchers

脳梗塞後炎症免疫機構および神経再生におけるFAPの機能解明と治療応用への検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel osteoporosis treatment using Microglia-Healing Peptides 1 (MHP1)

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

動脈硬化発症プロセスにおける一酸化窒素修飾がもたらすエンドセリン受容体機能の検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic vaccine for senolysis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological analysis and development of therapy in partial reperfusion in ischemic strokePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of vaccines using glycolipid antigens for anti-aging

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel immunotherapy for chronic inflammatory diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of roles of myeloid-derived suppressor cells on the regulation of post-ischemic inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel anti-inflammatory peptide targetting RANK signal in ischemic stroke

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutic approaches in ischemic stroke targeting regulation of inflammation through RANKL/RANK signalPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel therapy for Alzheimer's disease based on vascular modification

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ctarification of pathophysiology of remodeling after intracranial artery inJury model in mice in dystipidemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

頭蓋内脳動脈における血管形成術後の再狭窄の病態解明と治療法の開発Principal Investigator

SHIMAMURA MUNEHISA 島村宗尚

Munehisa Shimamura 島村宗尚

SHIMAMURA Munehisa 島村宗尚

島村宗尚シマムラムネヒサ