Ito Ryoji 伊藤亮治

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ITO Ryoji 伊藤亮治

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Researcher Number	60425436
Other IDs	https://orcid.org/0000-0003-2903-2332
Affiliation (Current)	2024: 公益財団法人実中研, 実験動物応用研究部, 室長
Affiliation (based on the past Project Information) *help	2024: 公益財団法人実中研, 実験動物応用研究部, 室長 2021 – 2023: 公益財団法人実験動物中央研究所, 実験動物応用研究部, 室長 2019 – 2021: 公益財団法人実験動物中央研究所, 実験動物研究部, 室長 2017 – 2019: 公益財団法人実験動物中央研究所, 実験動物研究部, 室長代理 2016: 公益財団法人実験動物中央研究所, 実験動物研究部, 研究員 … More 2012 – 2015: 公益財団法人実験動物中央研究所, その他部局等, 研究員 2012: 公益財団法人実験動物中央研究所, 免疫研究室, 研究員 2011: 公益財団法人実験動物中央研究所, 実験動物研究部・免疫研究室, 研究員 2010: (財)実験動物中央研究所, 実験動物研究部・免疫研究室, 研究員 2009: Central Institute for Experimental Animals, 免疫研究室, 研究員 2009: Central Institute for Experimental Animals, 免疫研究室, 研究員 2008: Central Institute for Experimental Animals, 実験動物研究部・免疫研究室, 研究員 2007: Central Institute for Experimental Animals, 実験動物研究部・免疫研究室, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Laboratory animal science / Laboratory animal science Except Principal Investigator Basic Section 52010:General internal medicine-related / Basic Section 42040:Laboratory animal science-related / Basic Section 53030:Respiratory medicine-related / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Laboratory animal science
Keywords	Principal Investigator ヒト化マウス / アレルギー / ヒト型抗体 / NOG-W41マウス / 造血幹細胞の増幅 / アトピー性皮膚炎 / 好酸球 / アレルギー性皮膚炎 / アトピー性皮膚炎モデル / 前臨床モデル … More / 喘息モデル / 喘息 / 気管支喘息 / ヒト免疫 / アレルギーモデル / ヒト遺伝子導入NOGマウス / ヒト抗体産生 / ヒト抗体 / 疾患モデル / B2細胞 … More Except Principal Investigator ヒト化マウス / ヒト糞便移植 / ヒト免疫系マウス / 無菌マウス / 喘息 / 気管支喘息 / アレルギー / 動物モデル / 免疫ヒト化マウス / ヒトマスト細胞 / 心身相関 / マスト細胞 / 心理社会的ストレス / ストレス / ヒト肺マスト細胞 / ヒト脳マスト細胞 / 腸管免疫 / 腸内細菌叢 / ステロイド抵抗性 / ハウスダスト / IgE / ステロイド / 気道過敏性 / 好酸球 / TSLP / IL-33 / iPS / IPS細胞 / 分化 / 免疫不全マウス / 胸腺 / 造血幹細胞 / iPS細胞 / 評価技術 / 乳がん患者 / ワクチン / 妊娠免疫 Less

デュアルヒト化マウスを用いたICIのバイオマーカーとなる腸内細菌叢の探索
- Principal Investigator
  
  何裕遥
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Central Institute for Experimental Medicine and Life Science
Elucidation of psychosomatic correlation mechanisms using the brain immune environment of immuno-humanized mice
- Principal Investigator
  
  丸岡秀一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Nihon University
気道上皮・骨髄・免疫ヒト化マウスの開発と難治性気道疾患克服に向けた研究基盤の確立
- Principal Investigator
  
  権寧博
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nihon University
高生着性次世代NOGマウスの開発と汎用的ヒト化マウス作製の基盤技術構築Principal Investigator
- Principal Investigator
  
  伊藤亮治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Central Institute for Experimental Animals
ヒトの腸内細菌叢と免疫系を再構築したデュアルヒト化マウスの開発
- Principal Investigator
  
  何裕遥
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Central Institute for Experimental Animals
免疫ヒト化マウスを用いた心理社会的ストレス関連喘息の分子病態の解明
- Principal Investigator
  
  丸岡秀一郎
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Nihon University
Development of atopic dermatitis models using humanized mice for eosinophil target therapyPrincipal Investigator
- Principal Investigator
  
  Ito Ryoji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Central Institute for Experimental Animals
Establishment and analysis of humanized murine model for refractory asthma
- Principal Investigator
  
  GON Yasuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nihon University
Approaches to standardization of humanized mice by transplanting human hematopoietic stem cells (HSC) and thymus generated from induced pluripotent stem (iPS) cells.
- Principal Investigator
  
  ITO MAMORU
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Central Institute for Experimental Animals
Establishment of a humoral immunity evaluation system based on the pregnant immunity system
- Principal Investigator
  
  KAMETANI Yoshie
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokai University
Development of human allergic asthma models using next-generation humanized mice for drug discoveryPrincipal Investigator
- Principal Investigator
  
  Ito Ryoji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Development of novel humanized mouse model recapiturated human allergic responses.Principal Investigator
- Principal Investigator
  
  Ito Ryoji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Development of human antibody producing mice with human immune systemsPrincipal Investigator
- Principal Investigator
  
  ITO Ryoji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals
Development of novel humanized NOG mice producing human IgG antibodyPrincipal Investigator
- Principal Investigator
  
  ITO Ryoji
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Central Institute for Experimental Animals

[Book] NOGマウス2019
- Author(s)
  伊藤守
- Total Pages
  4
- Publisher
  公益社団法人日本実験動物協会 Labio 21
- ISBN
- Data Source
  KAKENHI-PROJECT-18H03975
[Book] Humanized Mice for HIV Research2015
- Author(s)
  Ryoji Ito, Ikumi Katano and Mamoru Ito
- Total Pages
  8
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25430099
[Book] Humanized Mice Current Topics in Microbiology and Immunology2008
- Author(s)
  R. Ito
- Total Pages
  199
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-19700373
[Journal Article] Chemically defined cytokine-free expansion of human haematopoietic stem cells2023
- Author(s)
  Sakurai Masatoshi、Ishitsuka Kantaro、Ito Ryoji、Wilkinson Adam C.、Kimura Takaharu、Mizutani Eiji、Nishikii Hidekazu、Sudo Kazuhiro、Becker Hans Jiro、Takemoto Hiroshi、Sano Tsubasa、Kataoka Keisuke、Takahashi Satoshi、Nakamura Yukio、Kent David G　et al.
- Journal Title
  
  Nature
  
  Volume: 615 Issue: 7950 Pages: 127-133
- DOI
  10.1038/s41586-023-05739-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-21F21108, KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-23K21401
[Journal Article] High-progesterone environment preserves T cell competency by evading glucocorticoid effects on immune regulation.2022
- Author(s)
  Hirofumi Kashiwagi, Yumiko Goto, Hitoshi Ishimoto, Yoshie Kametani, et al.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 1-19
- DOI
  10.3389/fimmu.2022.1000728
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07828, KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-21K16823
[Journal Article] Efficient differentiation of human neutrophils with recapitulation of emergency granulopoiesis in human G-CSF knockin humanized mice2022
- Author(s)
  Ito Ryoji、Katano Ikumi、Kwok Immanuel W.H.、Ng Lai Guan、Ida-Tanaka Miyuki、Ohno Yusuke、Mu Yunmei、Celhar Teja、Yen Chan Jerry Kok、Takahashi Takeshi、Goto Motohito、Ogura Tomoyuki、Takahashi Riichi、Ito Mamoru
- Journal Title
  
  Cell Reports
  
  Volume: 41 Issue: 12 Pages: 111841-111841
- DOI
  10.1016/j.celrep.2022.111841
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02396, KAKENHI-PROJECT-20K06477
[Journal Article] Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors2022
- Author(s)
  Tanaka Yosuke....Goyama Susumu、Komatsu Norio、Takaku Tomoiku、Kitamura Toshio
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 271-271
- DOI
  10.1038/s41467-021-27928-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03685, KAKENHI-PROJECT-19H03688, KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-21K08376, KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-20H00537
[Journal Article] ヒト化マウスを用いたアレルギー疾患解析2021
- Author(s)
  伊藤亮治
- Journal Title
  
  臨床免疫アレルギー科
  
  Volume: 76 Pages: 229-234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06477
[Journal Article] DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes2021
- Author(s)
  Kayamori Kensuke、Nagai Yurie、Zhong Cheng、Kuribayashi Wakako、Oshima Motohiko、Nakajima-Takagi Yaeko、Yamashita Masayuki、Mimura Naoya、Becker Hans Jiro、Izawa Kiyoko、Yamazaki Satoshi、Iwano Satoshi、Ito Ryoji、Lennox William、Sheedy Josephine、Yokote Koutaro、Iwama Atsushi
- Journal Title
  
  Blood Advances
  
  Volume: 5 Issue: 2 Pages: 438-450
- DOI
  10.1182/bloodadvances.2020001461
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-20K21612, KAKENHI-PLANNED-19H05746, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-20J21190, KAKENHI-PROJECT-20H03178, KAKENHI-PROJECT-21K08366
[Journal Article] HER2-antigen-specific humoral immune response in breast cancer lymphocytes transplanted in hu-PBL hIL-4 NOG mice2021
- Author(s)
  Ohno Yusuke、Ohshima Shino、Miyamoto Asuka、Kametani Fuyuki、Ito Ryoji、Tsuda Banri、Kasama Yukie、Nakada Shunsuke、Kashiwagi Hirofumi、Seki Toshiro、Yasuda Atsushi、Ando Kiyoshi、Ito Mamoru、Tokuda Yutaka、Kametani Yoshie
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 12798-12798
- DOI
  10.1038/s41598-021-92311-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06477
[Journal Article] Improved engraftment of human peripheral blood mononuclear cells in NOG MHC double knockout mice generated using CRISPR/Cas92021
- Author(s)
  Ka Yuyo、Katano Ikumi、Nishinaka Eiko、Welcker Jochen、Mochizuki Misa、Kawai Kenji、Goto Motohito、Tomiyama Kayo、Ogura Tomoyuki、Yamamoto Taichi、Ito Mamoru、Ito Ryoji、Takahashi Riichi
- Journal Title
  
  Immunology Letters
  
  Volume: 229 Pages: 55-61
- DOI
  10.1016/j.imlet.2020.11.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06477
[Journal Article] Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody2021
- Author(s)
  Katano Ikumi、Hanazawa Asami、Otsuka Iyo、Yamaguchi Takuya、Mochizuki Misa、Kawai Kenji、Ito Ryoji、Goto Motohito、Kagawa Takahiro、Takahashi Takeshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 21087-21087
- DOI
  10.1038/s41598-021-00641-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06477
[Journal Article] Generation of Novel Human Red Blood Cell-Bearing Humanized Mouse Models Based on C3-Deficient NOG Mice2021
- Author(s)
  Yamaguchi Takuya、Katano Ikumi、Otsuka Iyo、Ito Ryoji、Mochizuki Misa、Goto Motohito、Takahashi Takeshi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 671648-671648
- DOI
  10.3389/fimmu.2021.671648
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06477
[Journal Article] Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells2021
- Author(s)
  Bo Wang, Shoichi Iriguchi, Masazumi Waseda, Norihiro Ueda, Tatsuki Ueda, Huaigeng Xu, Atsutaka Minagawa, Akihiro Ishikawa, Hisashi Yano, Tomoko Ishi, Ryoji Ito, Motohito Goto, Riichi Takahashi, Yasushi Uemura, Akitsu Hotta and Shin Kaneko
- Journal Title
  
  Nature Biomedical Engineering
  
  Volume: in press Issue: 5 Pages: 429-440
- DOI
  10.1038/s41551-021-00730-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23863, KAKENHI-PROJECT-19K16688, KAKENHI-PROJECT-20K06477
[Journal Article] Establishment of an integrated automated embryonic manipulation system for producing genetically modified mice2021
- Author(s)
  Eto Tomoo、Ueda Hiroki、Ito Ryoji、Takahashi Tsukasa、Watanabe Toshiaki、Goto Motohito、Sotomaru Yusuke、Tanaka Nobuaki、Takahashi Riichi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 15770-15770
- DOI
  10.1038/s41598-021-91148-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-20H05764, KAKENHI-PROJECT-19H01056, KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-21K06005, KAKENHI-PROJECT-20H03177
[Journal Article] Capturing differential 1 allele-level expression and genotypes of all classical HLA loci and haplotypes by a new capture RNA-Seq method.2020
- Author(s)
  Fumiko Yamamoto, Shingo Suzuki, Akiko Mizutani, Atsuko Shigenari, Sayaka Ito, Yoshie Kametani, Shunichi Kato, Marcelo Anibal Fernandez-Vina, Makoto Murata, Satoko Morishima, Yasuo Morishima, Masafumi Tanaka, Jerzy K Kulski, Seiamak Bahram, Takashi Shiina
- Journal Title
  
  Frontiers in Immunology
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03571
[Journal Article] Efficacy of the novel tubulin polymerization inhibitor PTC‐028 for myelodysplastic syndrome2020
- Author(s)
  Zhong Cheng、Kayamori Kensuke、Koide Shuhei、Shinoda Daisuke、Oshima Motohiko、Nakajima‐Takagi Yaeko、Nagai Yurie、Mimura Naoya、Sakaida Emiko、Yamazaki Satoshi、Iwano Satoshi、Miyawaki Atsushi、Ito Ryoji、Tohyama Kaoru、Yamaguchi Kiyoshi、Furukawa Yoichi、Lennox William、Sheedy Josephine、Weetall Marla、Iwama Atsushi
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 12 Pages: 4336-4347
- DOI
  10.1111/cas.14684
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-20K07563, KAKENHI-PROJECT-20K21612, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707
[Journal Article] Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse2020
- Author(s)
  Katano Ikumi、Ito Ryoji、Kawai Kenji、Takahashi Takeshi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 1-9
- DOI
  10.3389/fimmu.2020.532684
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-18H02368
[Journal Article] Bovine β-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-3/hGM-CSF transgenic mice2020
- Author(s)
  Ito Ryoji、Katano Ikumi、Otsuka Iyo、Takahashi Takeshi、Suemizu Hiroshi、Ito Mamoru、Simons Peter J
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 3 Pages: 183-189
- DOI
  10.1093/intimm/dxaa067
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06477, KAKENHI-PROJECT-18H02368
[Journal Article] Exacerbation of pathogenic Th17-cell-mediated cutaneous graft-versus-host-disease in human IL-1β and IL-23 transgenic humanized mice.2019
- Author(s)
  Ito R, Katano I, Otsuka I, Hanazawa A, Takahashi T, Kawai K, Yagoto M, Goto M, Ogura T, Takahashi R, Ito M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 516 Issue: 2 Pages: 480-485
- DOI
  10.1016/j.bbrc.2019.06.094
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-18H02368
[Journal Article] ヒト化IL-3/GM-CSFトランスジェニックマウス2019
- Author(s)
  伊藤亮治
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 71 Pages: 533-537
- Data Source
  KAKENHI-PROJECT-17H03571
[Journal Article] ヒト化マウスの作製とヒト疾患モデルへの応用2019
- Author(s)
  伊藤亮治
- Journal Title
  
  実験動物技術
  
  Volume: 54 Pages: 85-90
- Data Source
  KAKENHI-PROJECT-17H03571
[Journal Article] Recent Advances in Allergy Research Using Humanized Mice2019
- Author(s)
  Ito Ryoji、Maruoka Shuichiro、Gon Yasuhiro、Katano Ikumi、Takahashi Takeshi、Ito Mamoru、Izuhara Kenji、Nunomura Satoshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 11 Pages: 2740-2740
- DOI
  10.3390/ijms20112740
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07482, KAKENHI-PROJECT-19K08613, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-18H02368
[Journal Article] Humanized Mice as an Effective Evaluation System for Peptide Vaccines and Immune Checkpoint Inhibitors.2019
- Author(s)
  Kametani Y, Ohno Y, Ohshima S, Tsuda B, Yasuda A, Seki T, Ito R, Tokuda Y.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Issue: 24 Pages: 6337-6337
- DOI
  10.3390/ijms20246337
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-17K11298
[Journal Article] Significance of humanized mouse models for the evaluation of the humoral immune response against cancer vaccines.2018
- Author(s)
  Yoshie Kametani*, Asuka Miyamoto, Toshiro Seki, Ryoji Ito, Sonoko Habu, Yutaka Tokuda
- Journal Title
  
  Personalized Medicine Universe,
  
  Volume: 7 Pages: 13-18
- DOI
  10.1016/j.pmu.2018.04.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03571
[Journal Article] NOGマウスを用いた新しいxeno-GVHDモデル2018
- Author(s)
  伊藤亮治、伊藤守
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 70 Pages: 101-106
- NAID
  40021629079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07103
[Journal Article] A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis2018
- Author(s)
  Ito R, Maruoka S, Soda K, Katano I, Kawai K, Yagoto M, Hanazawa A, Takahashi T, Ogura T, Goto M, Takahashi R, Toyoshima S, Okayama Y, Izuhara K, Gon Y, Hashimoto S, Ito M, Nunomura S.
- Journal Title
  
  JCI Insight
  
  Volume: 3 Issue: 21
- DOI
  10.1172/jci.insight.121580
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07482, KAKENHI-PROJECT-16H05343, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-16K07103
[Journal Article] 次世代型ヒト化マウスの開発と創薬研究への応用2018
- Author(s)
  伊藤亮治
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 151 Pages: 160-165
- NAID
  130006655005
- Data Source
  KAKENHI-PROJECT-17H03571
[Journal Article] Enhanced Antibody Responses in a Novel NOG Transgenic Mouse with Restored Lymph Node Organogenesis2018
- Author(s)
  Takahashi Takeshi、Katano Ikumi、Ito Ryoji、Goto Motohito、Abe Hayato、Mizuno Seiya、Kawai Kenji、Sugiyama Fumihiro、Ito Mamoru
- Journal Title
  
  Front Immunol.
  
  Volume: 8 Pages: 2017-2017
- DOI
  10.3389/fimmu.2017.02017
- NAID
  120007134527
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-16H06276
[Journal Article] CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity2018
- Author(s)
  Negishi Naoko、Sato Takehito、Yamashita-Kanemaru Yumi、Shibuya Kazuko、Uchida Koichiro、Kametani Yoshie、Yagita Hideo、Kitaura Jiro、Okumura Ko、Habu Sonoko
- Journal Title
  
  ImmunoHorizons
  
  Volume: 2 Issue: 10 Pages: 338-348
- DOI
  10.4049/immunohorizons.1800033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05169, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-17H04217
[Journal Article] Comprehensive Analysis of the Activation and Proliferation Kinetics and Effector Functions of Human Lymphocytes, and Antigen Presentation Capacity of Antigen-Presenting Cells in Xenogeneic Graft-Versus-Host Disease2018
- Author(s)
  Kawasaki Yasufumi、Sato Kazuya、Hayakawa Hiroko、Takayama Norihito、Nakano Hirofumi、Ito Ryoji、Mashima Kiyomi、Oh Iekuni、Minakata Daisuke、Yamasaki Ryoko、Morita Kaoru、Ashizawa Masahiro、Yamamoto Chihiro、Hatano Kaoru、Fujiwara Shin-ichiro、Ohmine Ken、Muroi Kazuo、Kanda Yoshinobu
- Journal Title
  
  Biology of Blood and Marrow Transplantation
  
  Volume: 印刷中 Issue: 8 Pages: 1563-1574
- DOI
  10.1016/j.bbmt.2018.04.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430168, KAKENHI-PROJECT-18K08369, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-16K07103
[Journal Article] Development of the next generation humanized mouse for drug discovery2018
- Author(s)
  Ito Ryoji
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 151 Issue: 4 Pages: 160-165
- DOI
  10.1254/fpj.151.160
- NAID
  130006655005
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07103
[Journal Article] B-cell populations are expanded in breast cancer patients compared with healthy controls.2018
- Author(s)
  Tsuda B, Miyamoto A, Yokoyama K, Ogiya R, Oshitanai R, Terao M, Morioka T, Niikura N, Okamura T, Miyako H, Saito Y, Suzuki Y, Kametani Y, Tokuda Y
- Journal Title
  
  Breast Cancer
  
  Volume: 印刷中 Issue: 3 Pages: 284-291
- DOI
  10.1007/s12282-017-0824-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03571
[Journal Article] NOGマウスを用いた新しいxeno-GVHDモデル2018
- Author(s)
  伊藤亮治、伊藤守
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 70 Pages: 101-106
- NAID
  40021629079
- Data Source
  KAKENHI-PROJECT-17H03571
[Journal Article] The significance of humanized mouse models for the evaluation of the humoral immune response against cancer vaccines.2018
- Author(s)
  Yoshie Kametani*, Asuka Miyamoto, Toshiro Seki, Ryoji Ito, Sonoko Habu, Yutaka Tokuda
- Journal Title
  
  Personalized Medicine Universe
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03571
[Journal Article] Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice2018
- Author(s)
  Hanazawa Asami、Ito Ryoji、Katano Ikumi、Kawai Kenji、Goto Motohito、Suemizu Hiroshi、Kawakami Yutaka、Ito Mamoru、Takahashi Takeshi
- Journal Title
  
  Front Immunol.
  
  Volume: 9 Pages: 1-16
- DOI
  10.3389/fimmu.2018.00152
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-16K18404, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-26221005
[Journal Article] NOG-hIL-4-Tg, a new humanized mouse model for producing tumor antigen-specific IgG antibody by peptide vaccination2017
- Author(s)
  Kametani Yoshie、Katano Ikumi、Miyamoto Asuka、Kikuchi Yusuke、Ito Ryoji、Muguruma Yukari、Tsuda Banri、Habu Sonoko、Tokuda Yutaka、Ando Kiyoshi、Ito Mamoru
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 6 Pages: 0179239-0179239
- DOI
  10.1371/journal.pone.0179239
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-17H03572
[Journal Article] A novel in vivo model for predicting myelotoxicity of chemotherapeutic agents using IL-3/GM-CSF transgenic humanized mice2017
- Author(s)
  Ito R.、Nagai D.、Igo N.、Okuda Y.、Sekine K.、Ichimura E.、Katano I.、Mizushima T.、Goto M.、Ohnishi Y.、Ito M.、Okamoto K.
- Journal Title
  
  Toxicol Lett.
  
  Volume: 281 Pages: 152-157
- DOI
  10.1016/j.toxlet.2017.09.013
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-17H03571
[Journal Article] A novel xenogeneic graft-versus-host disease model for investigating the pathological role of human CD4+ or CD8+ T cells using immunodeficient NOG mice.2017
- Author(s)
  Ito R, Katano I, Kawai K, Yagoto M, Takahashi T, Ka Y, Ogura T, Takahashi R, Ito M
- Journal Title
  
  American Journal of Transplantation
  
  Volume: 5 Issue: 5 Pages: 1216-1228
- DOI
  10.1111/ajt.14116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290034, KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-16K18405, KAKENHI-PROJECT-17H03571
[Journal Article] Humanized mouse models: Application to human diseases2017
- Author(s)
  Ito Ryoji、Takahashi Takeshi、Ito Mamoru
- Journal Title
  
  J Cell Physiol.
  
  Volume: 233 Issue: 5 Pages: 3723-3728
- DOI
  10.1002/jcp.26045
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-18H03975
[Journal Article] Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses2017
- Author(s)
  Yaguchi Tomonori、Kobayashi Asuka、Inozume Takashi、Morii Kenji、Nagumo Haruna、Nishio Hiroshi、Iwata Takashi、Ka Yuyo、Katano Ikumi、Ito Ryoji、Ito Mamoru、Kawakami Yutaka
- Journal Title
  
  Cell Mol Immunol.
  
  Volume: 印刷中 Issue: 11 Pages: 1-10
- DOI
  10.1038/cmi.2017.106
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-16K10148, KAKENHI-PROJECT-26221005, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-15K09783
[Journal Article] Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse2017
- Author(s)
  Katano Ikumi、Nishime Chiyoko、Ito Ryoji、Kamisako Tsutomu、Mizusawa Takuma、Ka Yuyo、Ogura Tomoyuki、Suemizu Hiroshi、Kawakami Yutaka、Ito Mamoru、Takahashi Takeshi
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 17230-17230
- DOI
  10.1038/s41598-017-17442-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-26221005, KAKENHI-PROJECT-17H03571, KAKENHI-PROJECT-16K18405
[Journal Article] Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.2016
- Author(s)
  Sato K, Oiwa R, Kumita W, Henry R, Sakuma T, Ito R, Nozu R, Inoue T, Katano I, Sato K, Okahara N, Okahara J, Shimizu Y, Yamamoto M, Hanazawa K, Kawakami T, Kametani Y, Suzuki R, Takahashi T, Weinstein EJ, Yamamoto T, Sakakibara Y, Habu S, Hata J, Okano H, Sasaki E.
- Journal Title
  
  Cell Stem Cell
  
  Volume: 19 Issue: 1 Pages: 127-138
- DOI
  10.1016/j.stem.2016.06.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290034, KAKENHI-PROJECT-16K07103, KAKENHI-PROJECT-16K18405, KAKENHI-PROJECT-16K18478
[Journal Article] Visualization of the human CD4(+) T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/gammac(null) (NOG) mice by retrogenic expression of the human TCR gene2015
- Author(s)
  Takahashi, T. Katano, I. Ito, R. Ito, M.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 456 Issue: 1 Pages: 219-224
- DOI
  10.1016/j.bbrc.2014.11.062
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-25430099, KAKENHI-PROJECT-25871075, KAKENHI-PROJECT-26290034
[Journal Article] Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2-Producing Transgenic NOG Mouse2015
- Author(s)
  Katano, I. Takahashi, T. Ito, R. Kamisako, T. Mizusawa, T. Ka, Y. Ogura, T. Suemizu, H. Kawakami, Y. Ito, M.
- Journal Title
  
  J Immunol
  
  Volume: 194 Issue: 7 Pages: 3513-3525
- DOI
  10.4049/jimmunol.1401323
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-25871075, KAKENHI-PROJECT-26221005, KAKENHI-PROJECT-26290034, KAKENHI-PROJECT-25430099
[Journal Article] ヒト化マウスを用いたヒトアレルギーモデルの確立2015
- Author(s)
  伊藤亮治
- Journal Title
  
  アレルギーの臨床
  
  Volume: 478 Pages: 1164-8
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25430099
[Journal Article] NOD-Rag2null IL-2Rγnull mice: an alternative to NOG mice for generation of humanized mice.2014
- Author(s)
  Katano I, Ito R, Kamisako T, Eto T, Ogura T, Kawai K, Suemizu H, Takahashi T, Kawakami Y, Ito M.
- Journal Title
  
  Exp Anim.
  
  Volume: 63 Pages: 321-330
- NAID
  130004677826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430099
[Journal Article] Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged-12014
- Author(s)
  Negishi N, Suzuki D, Ito R, Irie N, Matsuo K, Yahata T, Nagano K, Aoki K, Ohya K, Hozumi K, Ando K, Tamaoki N, Ito M, Habu S
- Journal Title
  
  Experimental Hematology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430099
[Journal Article] Effective expansion of engrafted human hematopoietic stem cells in bone marrow of mice expressing human Jagged-12014
- Author(s)
  Negishi, N. Suzuki, D. Ito, R. Irie, N. Matsuo, K. Yahata, T. Nagano, K. Aoki, K. Ohya, K. Hozumi, K. Ando, K. Tamaoki, N. Ito, M. Habu, S.
- Journal Title
  
  Exp Hematol
  
  Volume: 42 Issue: 6 Pages: 487-94
- DOI
  10.1016/j.exphem.2014.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-24590361, KAKENHI-PROJECT-25430099
[Journal Article] Establishment of a Human Allergy Model Using Human IL-3/GM-CSF-Transgenic NOG Mice.2013
- Author(s)
  Ito, R., T. Takahashi, I. Katano, K. Kawai, T. Kamisako, T. Ogura, M. Ida-Tanaka, H. Suemizu, S. Nunomura, C. Ra, A. Mori, S. Aiso, and M. Ito.
- Journal Title
  
  J Immunol
  
  Volume: 191 Issue: 6 Pages: 2890-2899
- DOI
  10.4049/jimmunol.1203543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-23590561, KAKENHI-PROJECT-25430099, KAKENHI-PROJECT-25871075
[Journal Article] Efficient in vivo depletion of CD8+ T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration2013
- Author(s)
  Yoshida T, Suzuki S, Iwasaki Y, Kaneko A, Saito A, Enomoto Y, Higashino A, Watanabe A, Suzuki J, Inoue K, Kuroda T, Takada M, Ito R, Ito M, Akari H
- Journal Title
  
  Immunology Letters.
  
  Volume: 154 Issue: 1-2 Pages: 12-17
- DOI
  10.1016/j.imlet.2013.08.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J01032, KAKENHI-PROJECT-24500379, KAKENHI-PROJECT-24700428, KAKENHI-PUBLICLY-25110716, KAKENHI-PROJECT-25250003, KAKENHI-PROJECT-25430099, KAKENHI-PROJECT-25640011, KAKENHI-PROJECT-25670218
[Journal Article] Efficient xenoengraftment in severe immunodeficient NOD/Shi-scid IL2rgammanull mice is attributed to a lack of CD11c+B220+CD122+ cells2012
- Author(s)
  Ito, R.
- Journal Title
  
  J Immunol
  
  Volume: 189 Issue: 9 Pages: 4313-20
- DOI
  10.4049/jimmunol.1200820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-22700458
[Journal Article] Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γc^<null> mouse2012
- Author(s)
  Suzuki M, Takahashi T, Katano I, Ito R, Ito M, Harigae H, Ishii N, Sugamura K.
- Journal Title
  
  Int Immunol
  
  Volume: 24 Issue: 4 Pages: 243-52
- DOI
  10.1093/intimm/dxs045
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059005, KAKENHI-PROJECT-21390114, KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-22700458, KAKENHI-PROJECT-23590561, KAKENHI-PROJECT-24390118, KAKENHI-PROJECT-24659487
[Journal Article] Current advances in humanized mouse models2012
- Author(s)
  Ito, R.
- Journal Title
  
  Cell Mol Immunol
  
  Volume: 9 Issue: 3 Pages: 208-14
- DOI
  10.1038/cmi.2012.2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-22700458
[Journal Article] Efficient Xenoengraftment in Severe Immunodeficient NOD/Shi-scid IL2rγnull Mice Is Attributed to a Lack of CD11c+B220+CD122+ Cells.2012
- Author(s)
  Ito Ryoji
- Journal Title
  
  Journal of Immunology
  
  Volume: 189 Pages: 4313-4320
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700458
[Journal Article] Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts2012
- Author(s)
  Ito, R.
- Journal Title
  
  Exp Hematol
  
  Volume: 40 Issue: 11 Pages: 953-963
- DOI
  10.1016/j.exphem.2012.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22220007, KAKENHI-PROJECT-22700458
[Journal Article] Immunodeficient NOD-scid IL-2Rγ(null) mice do not display T and B cell leakiness2011
- Author(s)
  Katano I, Ito R, Eto T, Aiso S, Ito M
- Journal Title
  
  Exp Anim
  
  Volume: 60(2) Pages: 181-186
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21512274
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700458
[Journal Article] Highly sensitive model for xenogenic-GVHD using severe immunodeficient NOG mice2009
- Author(s)
  Ito R
- Journal Title
  
  Transplantation 87
  
  Pages: 1654-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700373
[Journal Article] The analysis of the functions of human B and T cells in humanized NOD/shi-scid/ gammac (null) (NOG) mice (hu-HSC NOG mice)2009
- Author(s)
  Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiya S, Sugamura K.
- Journal Title
  
  Int Immunol 21
  
  Pages: 843-58
- Data Source
  KAKENHI-PROJECT-19700373
[Journal Article] Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice2009
- Author(s)
  Ito R, Katano I, Kawai K, Hirata H, Ogura T, Kamisako T, Eto T, Ito M.
- Journal Title
  
  Transplantation 15
  
  Pages: 1654-8
- Data Source
  KAKENHI-PROJECT-19700373
[Journal Article] Antigen-specific antibody production of human B cells in NOG mice reconstituted with the human immune system2008
- Author(s)
  Ito R, Shiina M, Saito Y, Tokuda Y, Kametani Y, Habu S.
- Journal Title
  
  Curr Top Microbiol Immunol 324(Review)
  
  Pages: 95-107
- Data Source
  KAKENHI-PROJECT-19700373
[Patent] ヒト好中球が分化するヒトG-CSFノックインげっ歯類2019
- Inventor(s)
  伊藤亮治
- Industrial Property Rights Holder
  伊藤亮治
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16K07103
[Presentation] Improvement of human hematopoiesis in c-kit mutant NOG mice transferred with human HSCs2022
- Author(s)
  Ryoji Ito, Yunmei Mu, Yuyo Ka, Yusuke Ohno, Motohito Goto, Riichi Takahashi, Mamoru Ito
- Organizer
  第８４回日本血液学会
- Data Source
  KAKENHI-PROJECT-20K06477
[Presentation] ステロイド抵抗性喘息ヒト化マウスモデルを用いたベンラリズマブの治療効果検討2022
- Author(s)
  山田志保，豊島翔太，丸岡秀一郎，曽田香織，伊藤亮治，岡山吉道，權　寧博
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07400
[Presentation] ステロイド抵抗性喘息ヒト化マウスモデルを用いたベンラリズマブの治療効果検討2022
- Author(s)
  山田志保，豊島翔太，丸岡秀一郎，曽田香織，伊藤亮治，岡山吉道，權　寧博
- Organizer
  第3回日本喘息学会総会学術大会
- Data Source
  KAKENHI-PROJECT-21K07400
[Presentation] 微圧差センサを用いた吸入訓練　吸入療法における行動療法的アプローチの可能性2022
- Author(s)
  伊藤玲子，中川一人，肥田不二夫，釋　文雄，權　寧博，丸岡秀一郎
- Organizer
  第26回日本心療内科学会総会学術大会
- Data Source
  KAKENHI-PROJECT-21K07400
[Presentation] ヒト樹状細胞が分化する免疫系ヒト化マウスの開発2022
- Author(s)
  伊藤亮治、Yunmei Mu、大野裕介，後藤元人、高橋利一、伊藤守
- Organizer
  第69回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-20K06477
[Presentation] ステロイド抵抗性喘息ヒト化マウスモデルを用いたベンラリズマブの治療効果を検討2022
- Author(s)
  山田志保, 豊島翔太, 丸岡秀一郎, 曽田香織, 伊藤亮治, 岡山吉道, 權　寧博
- Organizer
  第71回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07400
[Presentation] 免疫不全マウスの開発とヒト化マウスへの応用2022
- Author(s)
  伊藤亮治
- Organizer
  第３６回日本下垂体研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06477
[Presentation] Human neutrophil differentiation in HSC-transferred NOG hG-CSF knock-in mice2022
- Author(s)
  Ryoji Ito, Ikumi Katano, Immanuel W.H. Kwok, Lai Guan Ng, Miyuki Ida-Tanaka, Yusuke Ohno, Teja Celhar, Motohito Goto, Riichi Takahashi, Mamoru Ito
- Organizer
  International workshop on humanized mice 6th
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06477
[Presentation] ヒト化IgE依存性喘息モデルの作製2022
- Author(s)
  山田志保, 豊島翔太，丸岡秀一郎，伊藤亮治，岡山吉道，權　寧博
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K07400
[Presentation] ヒト化自然免疫型喘息モデルを用いたベンラリズマブの治療効果検討2021
- Author(s)
  豊島翔太, 丸岡秀一郎, 曽田香織, 伊藤亮治, 山田志保,岡山吉道, 權寧博
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-21K07400
[Presentation] ヒト化自然免疫型喘息モデルを用いたベンラリズマブの治療効果検討; ミニシンポジウム13 喘息（自然免疫・性差）2021
- Author(s)
  豊島翔太, 丸岡秀一郎, 曽田香織, 伊藤亮治, 山田志保, 岡山吉道, 權　寧博
- Organizer
  第70回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08613
[Presentation] Development of human neutrophils in hG-CSF knockin NOG mouse transferred with human HSC2019
- Author(s)
  Ryoji Ito,
- Organizer
  103rd American Assosiation of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] NOG hIL-3/GM-CSF/IL-5 Tgマウスを用いたIL-33,ダニアレルゲン誘導型ヒト喘息モデルの開発2019
- Author(s)
  丸岡秀一郎, 伊藤亮治, 布村聡, 豊島翔太, 岡山吉道, 出原賢治, 橋本　修, 伊藤守, 權　寧博
- Organizer
  第59回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K08613
[Presentation] 次世代型免疫系ヒト化マウスと創薬研究2019
- Author(s)
  伊藤亮治
- Organizer
  第６６回日本実験動物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] NOG hIL-3/GM-CSF/IL-5 Tgマウスを用いたIL-33, ダニ誘導型ヒト喘息モデルの開発2019
- Author(s)
  山田志保, 丸岡秀一郎, 伊藤亮治, 布村聡, 豊島翔太, 岡山吉道, 出原賢治, 橋本　修, 伊藤守, 權　寧博
- Organizer
  第68回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-19K08613
[Presentation] Recent advances in GVHD study using humanized mice2019
- Author(s)
  Ryoji Ito
- Organizer
  hu-NITシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] CD4. A and CD4. B recognizing monoclonal antibody can detect Th activation condition of Microminipigs.2019
- Author(s)
  Shino Ohshima, Tatsuya Matsubara, Hitoshi Kitagawa, Asako Ando, Yoshie Kametani
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] 6.NOG-hIL-4-Tgマウスを用いた乳がん患者免疫応答とグルココルチコイドの関連性解析2019
- Author(s)
  大野裕介、大木廉太郎、大島志乃、津田万里、關敏郎、伊藤亮治、亀谷美恵
- Organizer
  日本下垂体研究会第34回学術集会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] Beta-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-3/GM-CSF Tg mice2019
- Author(s)
  伊藤亮治
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] ヒト化マウスNOGマウスを用いたヒト妊娠免疫の解析2019
- Author(s)
  大野裕介、宮本あすか、清水智香、柏木寛史、伊藤亮治、關敏郎、亀谷美恵
- Organizer
  第66回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] PD-1抗体副作用の抑制を目的とした妊娠関連プロテアーゼインヒビターを模倣する修飾ペプチド化合物の開発2019
- Author(s)
  亀谷美恵、石本人士、徳田裕、伊藤亮治、真鍋良幸
- Organizer
  第４回橋渡し研究戦略的推進プログラムシンポジウム
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] 乳癌新規ペプチドワクチン開発のためのヒト化マウスモデル2019
- Author(s)
  田俊輔、大木廉太朗、宮本あすか、伊藤亮治、津田万里、亀谷美恵
- Organizer
  第66回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] Progesterone effects on pregnant humoral immunity using humanized mice.2019
- Author(s)
  Yusuke Ohno, Tomoka Shimizu, Hirofumi Kashiwagi, Yumiko Goto, Toshiro Seki, Ryoji Ito, Hitoshi Ishimoto, Yoshie Kametani
- Organizer
  第14回国際生殖免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] CD155-transducing signaling through TIGIT plays an important role in transmission of tolerant state and suppression capacity.2018
- Author(s)
  Naoko Negishi, Takehito Sato, Yumi Kanemaru, Kazuko Shibuya, Koichiriro Uchida, Yoshie Kametani, Ko Okumura, Sonoko Habu
- Organizer
  第47回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] Humanized mouse as a model of human pregnant immunity.2018
- Author(s)
  Yusuke Ohno, Asuka Miyamoto, Ryoji Ito, Yoshie Kametani
- Organizer
  第47回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] ヒト妊娠免疫モデルとしての妊娠ヒト化マウスの解析2018
- Author(s)
  大野裕介、伊藤亮治、和泉俊一郎、伊藤守、亀谷美恵
- Organizer
  第33回日本下垂体研究会学術集会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] ヒト化マウスを用いたヒト妊娠免疫の解析2018
- Author(s)
  大野裕介、宮本あすか、伊藤亮治、亀谷美恵
- Organizer
  第33回日本生殖免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] 妊娠ヒト化マウスにおけるヒト白血球の動態解析2018
- Author(s)
  大野裕介、小島美香、木南理仁、伊藤守、亀谷美恵
- Organizer
  第65回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] Human G-CSF knockin NOG mice support the differentiation of human neutrophils and recapitulate an emergency granulopoiesis after bacterial infections2018
- Author(s)
  伊藤亮治
- Organizer
  第80回日本血液学会
- Data Source
  KAKENHI-PROJECT-16K07103
[Presentation] A humanized mouse model to study asthmatic airway inflammation via human IL-33/IL-13 axis2018
- Author(s)
  伊藤亮治
- Organizer
  2nd International symposium of humanized mouse model
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07103
[Presentation] Human CD4+ T cell-mediated cutaneous-GVHD in hIL-1b/IL-23 transgenic NOG mice2018
- Author(s)
  伊藤亮治
- Organizer
  第65回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-16K07103
[Presentation] Identification of CD4.B subtype of Microminipigs by a new monoclonal antibodies.2018
- Author(s)
  Shino Ohshima, Hitoshi Kitagawa, Asako Ando, Yoshie Kametani
- Organizer
  第47回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] ヒト化NOG-IL-4-Tgマウスを用いたペプチドワクチン投与効果の解析2017
- Author(s)
  宮本あすか、片野いくみ、伊藤亮治、津田万里、徳田裕、垣生園子、伊藤守、亀谷美恵
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] A novel in vivo model for predicting myelotoxicity of chemotherapeutic agents using IL-3/GM-CSF transgenic humanized mice2017
- Author(s)
  伊藤亮治
- Organizer
  実験動物学会
- Data Source
  KAKENHI-PROJECT-16K07103
[Presentation] NOG-IL-4-Tgマウスを用いたヒト組織移植の検討2017
- Author(s)
  宮本あすか、片野いくみ、伊藤亮治、津田万里、徳田裕、垣生園子、伊藤守、亀谷美恵
- Organizer
  第32回日本下垂体研究会学術集会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] Production of specific IgG against HER2 peptide is decreased in NOG-IL4-Tg mice transplanted with breast cancer patients PBMC:2017
- Author(s)
  Asuka Miyamoto, Ikumi Katano, Ryoji Ito, Banri Tsuda, Yutaka Tokuda, Sonoko Habu, Mamoru Ito, Yoshie Kametani
- Organizer
  第46回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] ト妊娠モデルとしての妊娠ヒト化マウス作製2017
- Author(s)
  大野裕介、小島美香、木南理仁、和泉俊一郎、伊藤亮治、伊藤守、亀谷美恵
- Organizer
  第32回日本下垂体研究会学術集会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] NOG-IL-4-tgを用いたヒト体液性免疫応答評価系の確立2017
- Author(s)
  亀谷美恵、宮本あすか、片野いくみ、伊藤亮治、津田万里、安藤清志、垣生園子、伊藤守、徳田裕
- Organizer
  国際個別化医療学会　2017年10月28日
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] Pregnant humanized mouse as a model of human pregnant immunity2017
- Author(s)
  Yusuke Ohno, Mika Kojima, Rihito Kinami, Shun-ichiro Izumi, Ryoji Ito, Mamoru Ito, Yoshie Kametani
- Organizer
  第46回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-17H03571
[Presentation] Generation of human asthmatic airway inflammation model by administration of IL-33 into novel humanized IL-3/GM-CSF/IL-5 transgenic NOG mice.2016
- Author(s)
  Ryoji Ito, Satoshi Nunomura, Ikumi Katano, Takeshi Takahashi, and Mamoru Ito
- Organizer
  5th International Workshop on Humanized Mice
- Place of Presentation
  チューリッヒ、スイス
- Year and Date
  2016-01-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430099
[Presentation] NOG hIL-3/GM-CSF/IL-5 Tgマウスを用いたIL-33誘導型ヒト喘息モデルの開発2016
- Author(s)
  伊藤亮治
- Organizer
  日本実験動物学会
- Place of Presentation
  川崎
- Year and Date
  2016-05-17
- Data Source
  KAKENHI-PROJECT-16K07103
[Presentation] A novel xenogeneic graft-versus-host disease model for investigating the pathological role of human CD4+ or CD8+ T cells using immunodeficient NOG mice2016
- Author(s)
  伊藤亮治
- Organizer
  日本免疫学会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K07103
[Presentation] NOG hIL-3/GM-CSF/IL-5 Tgマウスを用いたIL-33誘導型ヒト喘息モデルの開発2016
- Author(s)
  伊藤亮治
- Organizer
  アレルギー好酸球研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-16K07103
[Presentation] Intratracheal administration of IL-33 effectively induces eosinophilic airway inflammation in novel humanized NOG mice.2015
- Author(s)
  Ryoji Ito, Satoshi Nunomura, Ikumi Katano, Takeshi Takahashi, and Mamoru Ito
- Organizer
  日本免疫学会
- Place of Presentation
  札幌
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25430099
[Presentation] IgE-mediated allergic responses in human mast cells in humanized NOG mice expressing human IL-3 and GM-CSF2013
- Author(s)
  Ryoji Ito, Takeshi Takahashi, Ikumi Katano, Kenji Kawai, Satoshi Nunomura, Chisei Ra, Akio Mori, Sadakazu Aiso, Mamoru Ito
- Organizer
  第１５回国際免疫学会
- Place of Presentation
  イタリア・ミラノ
- Data Source
  KAKENHI-PROJECT-25430099
[Presentation] 生体内ヒトアレルギー応答を可能にしたヒト化マウスの開発2013
- Author(s)
  Ryoji Ito, Ikumi Katano, Takeshi Takahashi, Mamoru Ito
- Organizer
  第４２回日本免疫学会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-25430099
[Presentation] ヒトアレルギー反応を起こすヒト化モデルマウスの開発2013
- Author(s)
  伊藤亮治
- Organizer
  第６０回日本実験動物学会
- Place of Presentation
  茨城・つくば市
- Data Source
  KAKENHI-PROJECT-25430099
[Presentation] Human mast cell mediated allergic responses in humanized NOG mouse expressing human IL-3 and GM-CSF2013
- Author(s)
  Ryoji Ito, Takeshi Takahashi, Ikumi Katano, Kenji Kawai, Mamoru Ito
- Organizer
  4th International Workshop on Humanized mice
- Place of Presentation
  韓国・ソウル
- Data Source
  KAKENHI-PROJECT-25430099
[Presentation] Functional maturation of human myeloid cells in a NOD/SCID/IL2rγnull (NOG) transgenic humanized mouse strain expressing human IL-3 and GM-CSF2012
- Author(s)
  伊藤亮治
- Organizer
  日本免疫学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-22700458
[Presentation] ヒトIL-3/GM-CSFトランスジェニックNOGマウスにおけるヒトミエロイド系細胞の分化亢進2012
- Author(s)
  伊藤亮治
- Organizer
  日本実験動物学会
- Place of Presentation
  別府国際コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22700458
[Presentation] Establishment of efficient humanized mice improved myelopoiesis by using human IL-3/GM-CSF transgenic NOG mouse2012
- Author(s)
  伊藤亮治
- Organizer
  第59回日本実験動物学会
- Place of Presentation
  別府
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-22700458
[Presentation] ヒトIL-3/GM-CSFトランスジェニックNOGマウスを用いたヒトアレルギーモデルの確立2012
- Author(s)
  伊藤亮治
- Organizer
  第62回日本アレルギー学会
- Place of Presentation
  大阪
- Year and Date
  2012-11-29
- Data Source
  KAKENHI-PROJECT-22700458
[Presentation] Development of a human allergy model animal using novel NOG transgenic humanized mouse strain expressing human IL-3 and GM-CSF2012
- Author(s)
  伊藤亮治
- Organizer
  第41回日本免疫学会
- Place of Presentation
  神戸
- Year and Date
  2012-12-01
- Data Source
  KAKENHI-PROJECT-22700458
[Presentation] ヒトIL-3/GM-CSFトランスジェニックNOGマウスを用いたヒトアレルギーモデルの確立2012
- Author(s)
  伊藤亮治
- Organizer
  日本アレルギー学会
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-22700458
[Presentation] A novel humanized mouse model : improvement of human myelopoiesis in IL-3/GM-CSF transgenic NOG mouse reconstituted with human hematopoietic stem cells2012
- Author(s)
  伊藤亮治
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉県:幕張メッセ
- Year and Date
  2012-11-27
- Data Source
  KAKENHI-PROJECT-22700458
[Presentation] NOG IL-3/GM-CSF Tgマウスにおける機能的ヒトミエロイド系細胞分化2011
- Author(s)
  伊藤亮治
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22700458
[Presentation] Interferon-gamma produced by IKDC has a crucial role in suppression of xeno-GVHD in NOG mice2010
- Author(s)
  Ito Ryoji
- Organizer
  International Workshop on Dendritic Cells
- Place of Presentation
  Lugano, Swiss
- Year and Date
  2010-09-27
- Data Source
  KAKENHI-PROJECT-22700458
[Presentation] Pathological state in Xeno-GVHD induced by human CD4 or CD8 T cells2010
- Author(s)
  伊藤亮治
- Organizer
  14th International Congress of Immunology in Kobe
- Place of Presentation
  Japan
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-22700458
[Presentation] Interferon-gamma produced by IKDC has a crucial role in suppression of xeno-GVHD in NOG mice2010
- Author(s)
  伊藤亮治
- Organizer
  11th International Symposium on Dendritic Cells in Lugano
- Place of Presentation
  Swiss
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22700458
[Presentation] High sensitivity to xeno-GVHD in severely immunodeficient NOG mice is attributable to dysfunction of dendritic cells2009
- Author(s)
  Ryoji Ito, Ikumi Katano, Tomoyuki Ogura, Kenji Kawai, Mamoru Ito
- Organizer
  2nd International Workshop on Humanized Mice
- Data Source
  KAKENHI-PROJECT-19700373
[Presentation] IFNγ producing killer dendritic cells have a suppressive effect on xeno-GVHD in NOG mice2009
- Author(s)
  Ryoji Ito, Ikumi Katano, Kenji Kawai, Mamoru Ito
- Organizer
  第39回日本免疫学会
- Data Source
  KAKENHI-PROJECT-19700373
[Presentation] High sensitivity to xeno-GVHD in severely immunodeficient NOG mice is attributable to dysfunction of dendritic cells2009
- Author(s)
  伊藤亮治
- Organizer
  2^<nd> International Workshop on Humanized Mice
- Place of Presentation
  St.Olofskapel of the Barbizon hotel, Amsterdam
- Year and Date
  2009-04-03
- Data Source
  KAKENHI-PROJECT-19700373
[Presentation] ヒトDelta-like 1トランスジェニックNOGマウスに発症する骨硬化はヒト造血系の再構築を抑制する2008
- Author(s)
  伊藤亮治、小倉智幸、入江奈緒子、松尾光一、垣生園子、伊藤守
- Organizer
  第26回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-19700373
[Presentation] 重度免疫不全NOGマウスを用いた高GVHD感受性モデル2008
- Author(s)
  伊藤亮治、小倉智幸、川井健司、伊藤守
- Organizer
  第55回日本実験動物学会
- Data Source
  KAKENHI-PROJECT-19700373
[Presentation] Dendritic cells have a suppressive effect on xeno-GVHD in novel immunodeficient NOG mice2008
- Author(s)
  Ryoji ITO, Ikumi KATANO, Tomoyuki OGURA, Kenji KAWAI, Mamoru ITO
- Organizer
  10th International Symposium on Dendritic Cells
- Data Source
  KAKENHI-PROJECT-19700373

1. GON Yasuhiro (80339316)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. 丸岡秀一郎 (80599358)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
3. 何裕遥 (90640772)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 岡山吉道 (80292605)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. KAMETANI Yoshie (50338787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 24 results
6. ITO MAMORU (00176364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. 真鍋良幸 (00632093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 徳田裕 (20163975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
9. 清水哲男 (00339326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 鈴木大介 (10439698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. GOTO Yumiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. YAHATA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. Sato Kazuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. Kanemaru Yumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. SUEMIZU Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. KATANO Ikumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. 石本人士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 安藤潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 高橋武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
20. 石井直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 渋谷和子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 大嶺謙

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 合山進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 王博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 渡部聡朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ito Ryoji 伊藤 亮治

ITO Ryoji 伊藤 亮治

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高生着性次世代NOGマウスの開発と汎用的ヒト化マウス作製の基盤技術構築Principal Investigator

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Development of atopic dermatitis models using humanized mice for eosinophil target therapyPrincipal Investigator

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Development of human allergic asthma models using next-generation humanized mice for drug discoveryPrincipal Investigator

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Development of novel humanized mouse model recapiturated human allergic responses.Principal Investigator

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Development of human antibody producing mice with human immune systemsPrincipal Investigator

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Development of novel humanized NOG mice producing human IgG antibodyPrincipal Investigator

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Ito Ryoji 伊藤亮治

ITO Ryoji 伊藤亮治