Hosokawa Hiroyuki 細川裕之

… Alternative Names

HOSOKAWA HIROYUKI 細川裕之

細川裕之ホソカワヒロユキ

HOSOKAWA Hiroyuki 細川裕之

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Researcher Number	60431756
Other IDs	https://orcid.org/0000-0002-9592-2889
Affiliation (Current)	2025: 東海大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 東海大学, 医学部, 准教授 2021: 東海大学, 医学部, 講師 2019 – 2020: 東海大学, 医学部, 特任講師 2014: 千葉大学, 医学(系)研究科(研究院), 助教 2012: 千葉大学, 大学院・医学研究院, 助教 … More 2011 – 2012: 千葉大学, 医学(系)研究科(研究院), 助教 2007 – 2009: Chiba University, 大学院・医学研究院, 助教 2006: 千葉大学, 大学院医学研究院, 助手 Less
Review Section/Research Field	Principal Investigator Immunology / Basic Section 54010:Hematology and medical oncology-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields Except Principal Investigator Immunology
Keywords	Principal Investigator GATA3 / 細胞運命決定 / T細胞 / アレルギー / Th2細胞 / 転写因子ネットワーク / Notchシグナル / 翻訳後修飾 / Th2 / マスター転写因子 … More / Bcl11b / ILC2 / RUNX転写因子 / プロテオミクス解析 / 細胞の運命決定 / T細胞初期分化 / 系列決定 / 遺伝子発現制御 / 転写因子 / 発生段階特異的 / 転写制御ネットワーク / 造血幹細胞 / T前駆細胞 / IL-5 / アレルギー･ぜんそく / 発現制御 / アレルギー・ぜんそく / プロテオミクス / クロマチン / ユビキチン化 / Bmi-1 / Th1 / ポリコーム群遺伝子 / 免疫学 … More Except Principal Investigator Trithorax / Polycomb / Memory T cell / Asthma / Allergy / Chromatin remodeling / Immunology / 発生・分化 / シグナル伝達 / トライソラックス / ポリコーム / 記憶T細胞 / アレルギー・喘息 / クロマチンリモデリング / 免疫学 Less

Notch-dependent functional conversion of RUNX transcription factors regulates the initiation of T-lineage programPrincipal Investigator
- Principal Investigator
  
  細川裕之
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokai University
Are the cell-type specific actions of master transcription factors controlled by the organization of functional protein complexes?Principal Investigator
- Principal Investigator
  
  細川裕之
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Tokai University
Stage-specific roles of Notch signaling on induction of T cell development from hematopoietic progenitor cellsPrincipal Investigator
- Principal Investigator
  
  HOSOKAWA HIROYUKI
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokai University
活性型/抑制型GATA3複合体の形成と制御メカニズムの解明Principal Investigator
- Principal Investigator
  
  細川裕之
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Functions of posttranscriptional regulation of GATA3 in Th2 cellsPrincipal Investigator
- Principal Investigator
  
  HOSOKAWA Hiroyuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Identification of the functional molecular complexes of GATA3 in Th2 cells.Principal Investigator
- Principal Investigator
  
  HOSOKAWA Hiroyuki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
ポリコーム群遺伝子Bmi-1によるGATA3のタンパク質安定性制御機構の解明Principal Investigator
- Principal Investigator
  
  細川裕之
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Immunology
- Research Institution
  Chiba University
Regulation of chromatin remodeling in differentiation and maintenance of Th1/Th2 cells
- Principal Investigator
  
  NAKAYAMA Toshinori
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Chiba University

[Book] 医学のあゆみ2014
- Author(s)
  細川裕之、中山俊憲
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-26460569
[Journal Article] GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma2022
- Author(s)
  Suzuki Sawako、Venkatesh Divya、Kanda Hiroaki、Nakayama Akitoshi、Hosokawa Hiroyuki、Lee Eunyoung、Miki Takashi、Stockwell Brent R.、Yokote Koutaro、Tanaka Tomoaki、Prives Carol
- Journal Title
  
  Cancer Research
  
  Volume: 82 Issue: 18 Pages: 3209-3222
- DOI
  10.1158/0008-5472.can-21-3914
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07205, KAKENHI-PROJECT-22K08325, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-21K19398, KAKENHI-PROJECT-23K24062
[Journal Article] Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis2022
- Author(s)
  Fujimoto Masanori、Yokoyama Masataka、Kiuchi Masahiro、Hosokawa Hiroyuki、Nakayama Akitoshi、Hashimoto Naoko、Sakuma Ikki、Nagano Hidekazu、Yamagata Kazuyuki、Kudo Fujimi、Manabe Ichiro、Lee Eunyoung、Hatano Ryo、Onodera Atsushi、Hirahara Kiyoshi、Yokote Koutaro、Miki Takashi、Nakayama Toshinori、Tanaka Tomoaki
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 1-21
- DOI
  10.1038/s41467-022-33171-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08524, KAKENHI-PROJECT-22K07205, KAKENHI-PROJECT-22K08619, KAKENHI-PROJECT-22K08644, KAKENHI-PROJECT-22K15485, KAKENHI-PROJECT-20KK0373, KAKENHI-ORGANIZER-21H05120, KAKENHI-PLANNED-21H05121, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20H03685, KAKENHI-PROJECT-21H02974, KAKENHI-PROJECT-20K07561, KAKENHI-PROJECT-20K08397, KAKENHI-PROJECT-20K08583, KAKENHI-PROJECT-21K19398, KAKENHI-PROJECT-20KK0351, KAKENHI-PROJECT-23K24062, KAKENHI-PROJECT-23K24147
[Journal Article] Transcription factor Zbtb1 interacts with bridging factor Lmo2 and maintains the T-lineage differentiation capacity of lymphoid progenitor cells2022
- Author(s)
  Koizumi Maria、Kama Yuichi、Hirano Ken-ichi、Endo Yusuke、Tanaka Tomoaki、Hozumi Katsuto、Hosokawa Hiroyuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 11 Pages: 102506-102506
- DOI
  10.1016/j.jbc.2022.102506
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16331, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20H03455
[Journal Article] Transcription factors regulate early T?cell development via redeployment of other factors2021
- Author(s)
  Hosokawa Hiroyuki、Masuhara Kaori、Koizumi Maria
- Journal Title
  
  BioEssays
  
  Volume: 43 Issue: 5 Pages: 2000345-2000345
- DOI
  10.1002/bies.202000345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03692
[Journal Article] Notch signaling supports the appearance of follicular helper T cells in the Peyer's patches concomitantly with the reduction of regulatory T cells2021
- Author(s)
  Yazawa M, Hosokawa H, Koizumi M, Hirano KI, Imai J, Hozumi K.
- Journal Title
  
  Int Immunol
  
  Volume: 33(9) Issue: 9 Pages: 469-478
- DOI
  10.1093/intimm/dxab032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20K07330
[Journal Article] LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice2021
- Author(s)
  Hirano K., Hosokawa H., Koizumi M., Endo Y., Yahata T., and Hozumi K
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.68227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21618, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20H03455, KAKENHI-PROJECT-20K07330, KAKENHI-PROJECT-23K21386
[Journal Article] Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium2021
- Author(s)
  Hirano KI, Hosokawa H, Yahata T, Ando K, Tanaka M, Imai J, Yazawa M, Ohtsuka M, Negishi N, Habu S, Sato T, Hozumi K.
- Journal Title
  
  Front Immunol
  
  Volume: 13 Pages: 852427-852427
- DOI
  10.3389/fimmu.2022.852427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-20K07330, KAKENHI-PROJECT-22K08042, KAKENHI-PROJECT-23K21386
[Journal Article] Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching2021
- Author(s)
  Shin Boyoung、Hosokawa Hiroyuki、Romero-Wolf Maile、Zhou Wen、Masuhara Kaori、Tobin Victoria R.、Levanon Ditsa、Groner Yoram、Rothenberg Ellen V.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 4
- DOI
  10.1073/pnas.2019655118
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03692
[Journal Article] Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells2021
- Author(s)
  Hosokawa Hiroyuki、Koizumi Maria、Masuhara Kaori、Romero-Wolf Maile、Tanaka Tomoaki、Nakayama Toshinori、Rothenberg Ellen V.
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 218(8) Issue: 8 Pages: 1-16
- DOI
  10.1084/jem.20202648
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20383, KAKENHI-PROJECT-19H05650, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-19H03708, KAKENHI-PROJECT-21K19398
[Journal Article] Cell type-specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells.2020
- Author(s)
  Hosokawa H, Romero-Wolf M, Yang Q, Motomura Y, Levanon D, Groner Y, Moro K, Tanaka T, Rothenberg EV.
- Journal Title
  
  J Exp Med.
  
  Volume: 217(1) Issue: 1
- DOI
  10.1084/jem.20190972
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05286, KAKENHI-PROJECT-19H03692, KAKENHI-PROJECT-19H03708
[Journal Article] AMBRA1 controls antigen-driven activation and proliferation of naive T cells2020
- Author(s)
  Masuhara Kaori、Akatsuka Hisako、Tokusanai Mizuki、Li Chenyang、Iida Yumi、Okada Yoshinori、Suzuki Takahiro、Ohtsuka Masato、Inoue Ituro、Kimura Minoru、Hosokawa Hiroyuki、Hozumi Katsuto、Sato Takehito
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 2 Pages: 107-118
- DOI
  10.1093/intimm/dxaa063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03692
[Journal Article] How transcription factors drive choice of the T cell fate2020
- Author(s)
  Hosokawa Hiroyuki、Rothenberg Ellen V.
- Journal Title
  
  Nature Reviews Immunology
  
  Volume: 21 Issue: 3 Pages: 162-176
- DOI
  10.1038/s41577-020-00426-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03692
[Journal Article] Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development2020
- Author(s)
  Romero-Wolf Maile、Shin Boyoung、Zhou Wen、Koizumi Maria、Rothenberg Ellen V.、Hosokawa Hiroyuki
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 219 Issue: 10
- DOI
  10.1083/jcb.202005093
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03692
[Journal Article] Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development.2014
- Author(s)
  Mishima Y, Wang C, Miyagi S, Saraya A, Hosokawa H, Mochizuki-Kashio M, Nakajima-Takagi Y, Koide S, Negishi M, Sashida G, Naito T, Ishikura T, Onodera A, Nakayama T, Tenen DG, Yamaguchi N, Koseki H, Taniuchi I, Iwama A.
- Journal Title
  
  Nature Communications
  
  Volume: 18 Issue: 1 Pages: 5872-5882
- DOI
  10.1038/ncomms6872
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-14J40042, KAKENHI-PROJECT-24249054, KAKENHI-PROJECT-25460599, KAKENHI-PROJECT-25860351, KAKENHI-PUBLICLY-26114720, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26293109, KAKENHI-PROJECT-26460569, KAKENHI-PROJECT-26461396
[Journal Article] The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-・ and suppresses TH2 differentiation2012
- Author(s)
  Kuwahara, M., Yamashita, M., Shinoda, K., Tofukuji, S., Onodera, A., Shinnakasu, R., Motohashi, S., Hosokawa, H., Tumes, D., Iwamura, C., Lefebvre, V., and Nakayama, T.
- Journal Title
  
  Nat. Immunol
  
  Volume: 13(8) Issue: 8 Pages: 778-786
- DOI
  10.1038/ni.2362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591093, KAKENHI-PROJECT-23390075, KAKENHI-PROJECT-23592624, KAKENHI-PROJECT-23659240, KAKENHI-PROJECT-23790522, KAKENHI-PROJECT-23790523, KAKENHI-PROJECT-23890030, KAKENHI-PROJECT-24592083, KAKENHI-PROJECT-24790459
[Journal Article] Type II membrane protein CD69 regulates the formation of resting T-helper memory2012
- Author(s)
  Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Zehentmeier, S., Hosokawa, H., Iwamura, C, Koseki, H., Tumes, D.J., Radbruch, A., Nakayama T.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: (in press) Issue: 19 Pages: 7409-7414
- DOI
  10.1073/pnas.1118539109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J56132, KAKENHI-PUBLICLY-22021011, KAKENHI-PROJECT-22591093, KAKENHI-PROJECT-22689014, KAKENHI-PROJECT-23659240, KAKENHI-PROJECT-23790522, KAKENHI-PROJECT-23890030
[Journal Article] Sublingual administration of Lactobacillus paracasei KW3110 inhibits Th2-dependent allergic responses via upregulation of PD-L2 on dendritic cells.2012
- Author(s)
  Inamine, A., Sakurai, D., Horiguchi, S., Yonekura, S., Hanazawa, T., Hosokawa, H., Matuura-Suzuki, A., Nakayama, T., and Okamoto, Y.
- Journal Title
  
  Clin. Immunol.
  
  Volume: 143 Issue: 2 Pages: 170-179
- DOI
  10.1016/j.clim.2012.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790522
[Journal Article] Murine Schnurri-2 controls Natural Killer cell function and lymphoma development2012
- Author(s)
  Yamashita, J., Iwamura, C., Mitsumori, K., Hosokawa, H., Sasaki, T., Takahashi, M., Tanaka, H., Kaneko, K., Hanazawa, A., Watanabe, Y., Shinoda, K., Tumes, D., Motohashi, S., Nakayama, T.
- Journal Title
  
  Leuk.Lymphoma
  
  Volume: 53 Issue: 3 Pages: 479-486
- DOI
  10.3109/10428194.2011.625099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J56132, KAKENHI-PROJECT-21390147, KAKENHI-PROJECT-21591808, KAKENHI-PROJECT-22790452, KAKENHI-PROJECT-23592624, KAKENHI-PROJECT-23659240, KAKENHI-PROJECT-23790522, KAKENHI-PROJECT-23890030, KAKENHI-PROJECT-24592083
[Journal Article] Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development.2012
- Author(s)
  Lavial, F., Bessonnard, S., Ohnishi, Y., Tsumura, A., Chandrashekran, A., Fenwick, M., Tomaz, R. A., Hosokawa, H., Nakayama, T., Chambers, I., Hiiragi, T., Chazaud, C., and Azuara, V.
- Journal Title
  
  Genes Dev.
  
  Volume: 26 Issue: 13 Pages: 1445-1458
- DOI
  10.1101/gad.188193.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790522
[Journal Article] Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA32011
- Author(s)
  Endo, Y., Iwamura, C., Kuwahara, M., Suzuki, A., Sugaya, K., Tumes, J. D., Tokoyoda, K. Hosokawa, H., Yamashita, M. Nakayama, T
- Journal Title
  
  Immunity
  
  Volume: 35 Issue: 5 Pages: 733-745
- DOI
  10.1016/j.immuni.2011.08.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390147, KAKENHI-PUBLICLY-22021008, KAKENHI-PUBLICLY-22021011, KAKENHI-PROJECT-22591093, KAKENHI-PROJECT-22689014, KAKENHI-PROJECT-22790452, KAKENHI-PROJECT-23659240, KAKENHI-PROJECT-23790522
[Journal Article] Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA32011
- Author(s)
  Horiuchi, S., Onodera, A., Hosokawa, H., Watanabe, Y., Tanaka, T., Sugano, S., SuzukiY. Nakayama, T
- Journal Title
  
  J. Immunol
  
  Volume: 186 Issue: 11 Pages: 6378-6389
- DOI
  10.4049/jimmunol.1100179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390147, KAKENHI-PROJECT-22591093, KAKENHI-PROJECT-23659240, KAKENHI-PROJECT-23790522, KAKENHI-PROJECT-23790523, KAKENHI-PROJECT-221S0002
[Journal Article] Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice.2009
- Author(s)
  Kitajima, M., Iwamura, C., Miki, H.T., Shinoda, K., Endo, Y., Watanabe, Y., Shinnakasu, R., Hosokawa, H., Hashimoto, K., Motohashi, S., Koseki, H., Ohara, O., Yamashita, M., Nakayama, T.
- Journal Title
  
  J. Immunol. 183
  
  Pages: 5388-5396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790367
[Journal Article] cAMPQ1 activation by PACAP/VIP stimulates IL-6 release and inhibits osteoblastic differentiation through VPAC2 receptor in osteoblastic MC3T3 cells.2009
- Author(s)
  Nagata, A., Tanaka, T., Minezawa, A., Poyurovsky, M., Mayama, T., Suzuki, S., Hashimoto, N., Yoshida, T., Suyama, K., Miyata, A., Hosokawa, H., Nakayama, T., Tatsuno, I.
- Journal Title
  
  J. Cell. Physiol. 221
  
  Pages: 75-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790367
[Journal Article] CD69 controls the pathogenesis of allergic airway inflammation.2009
- Author(s)
  Miki, H.T., Hasegawa, A., Iwamura, C., Shinoda, K., Tofukuji, S., Watanabe, Y., Hosokawa, H., Motohashi, S., Hashimoto, K., Shirai, M., Yamashita, M., Nakayama, T.
- Journal Title
  
  J. Immunol. 183
  
  Pages: 8203-8215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790367
[Journal Article] Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation.2008
- Author(s)
  Shinnakasu, R., Yamashita, M., Kuwahara, M., Hosokawa, H., Hasegawa, A., Motohashi, S., Nakayama, T.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 28216-28225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790367
[Journal Article] Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo -1722008
- Author(s)
  Ito, T., Hasegawa, A., Hosokawa, H., Yamashita, M., Motohashi, S., Naka, T., Okamoto, Y., Fujita, Y., Ishii, Y., Taniguchi, M., Yano, I., Nakayama, T.
- Journal Title
  
  Int. Immunol. 20
  
  Pages: 849-860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790367
[Journal Article] Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene.2008
- Author(s)
  Yamashita, M., Kuwahara, M., Suzuki, A. 、, Hirahara, K., Shinnakasu, R., Hosokawa, H., Hasegawa, A., Motohashi, S., Iwama, A., Nakayama, T.
- Journal Title
  
  Exp. Med. 205
  
  Pages: 1109-1120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790367
[Journal Article] Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells.2008
- Author(s)
  Hossain, M.B., Hosokawa, H., Hasegawa, A., Watarai, H., Taniguchi, M., Yamashita, M., Nakayama, T.
- Journal Title
  
  Immunology 125
  
  Pages: 377-386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790367
[Journal Article] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3.2006
- Author(s)
  Hosokawa, H.
- Journal Title
  
  J. Immunol. 177
  
  Pages: 7656-7664
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390139
[Journal Article] Regulation of Th2 development by Polycomb group gene bmi-1 through the stabilization of GATA3.2006
- Author(s)
  Hosokawa, H.
- Journal Title
  
  J. Immunol. 177・12
  
  Pages: 7656-7664
- Data Source
  KAKENHI-PROJECT-17390139
[Journal Article] Regulation of Th2 cell development by Polvcomb group gene bmi-1 through the stabilization of GATA32006
- Author(s)
  Hosokawa, H.
- Journal Title
  
  J. Immunol 177
  
  Pages: 7656-7664
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390139
[Journal Article] Regulation of Th2 cell development by polycomb group gene bmi-1 throug the stabilization of GATA3.2006
- Author(s)
  Hosokawa, H.
- Journal Title
  
  J. Immunol. 177・11
  
  Pages: 7656-7664
- Data Source
  KAKENHI-PROJECT-18890046
[Presentation] Etv6 is a Tcf7- and Hes1-independent Notch target gene in the initiation of the T-lineage program2024
- Author(s)
  Kenichi Hirano, Hiroyuki Hosokawa
- Organizer
  第52回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03692
[Presentation] T細胞の発生を誘導するNotchシグナルの全容の解明2023
- Author(s)
  平野健一、細川裕之
- Organizer
  京都T cell conference
- Data Source
  KAKENHI-PROJECT-19H03692
[Presentation] Etv6 is a Tcf7- and Hes1-independent Notch target gene in the initiation of the T-lineage program2023
- Author(s)
  Kenichi Hirano, Hiroyuki Hosokawa
- Organizer
  FASEB
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03692
[Presentation] Notch signaling triggers T-lineage program via Tcf7-dependnent and -independent mechanisms2022
- Author(s)
  Ken-ichi Hirano, Hiroyuki Hosokawa
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03692
[Presentation] Notch signaling triggers T-lineage program via Tcf7-dependnent and -independent mechanisms2022
- Author(s)
  Hiroyuki Hosokawa
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03692
[Presentation] Notch-dependent functional conversion of Runx1 at the initiation of T-lineage program2022
- Author(s)
  Yuichi Kama, Hiroyuki Hosokawa
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03692
[Presentation] 初期T 細胞分化におけるPU.1 発現抑制メカニズムの解析2019
- Author(s)
  細川裕之
- Organizer
  Kyoto T Cell Conference
- Data Source
  KAKENHI-PROJECT-19H03692
[Presentation] T細胞の初期発生において転写因子PU.1はコファクターを再配置することにより遺伝子発現を制御する2019
- Author(s)
  細川裕之
- Organizer
  日本分子生物学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03692
[Presentation] GATA3 and Runx1 repress PU.1 expression in early T cell development2019
- Author(s)
  Hiroyuki Hosokawa, Katsuto Hozumi, Ellen Rothenberg
- Organizer
  日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-19H03692
[Presentation] GATA3 and Runx1 repress PU.1 expression in early T cell development2019
- Author(s)
  Hiroyuki Hosokawa, Ellen Rothenberg
- Organizer
  FASEB 'The Molecular Mechanisms of Immune Cell Development and Function Coference'
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03692
[Presentation] Functionally distinct GATA3 complexes regulate Th2 cell differentiation and proliferation.2014
- Author(s)
  Hosokawa, H., Shinoda, K., Suzuki, A., Ito, T., and Nakayama, T.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都府
- Year and Date
  2014-12-12
- Data Source
  KAKENHI-PROJECT-26460569
[Presentation] The polycomb protein Ezh2 regulates differentiation and plasticity of CD4 T helper type-1 and type-2 cells.2014
- Author(s)
  Tumes, J. D., Onodera, A., Hosokawa, H., Koseki, H., Suzuki, Y., Motohashi, S., and Nakayama, T.
- Organizer
  第24回Kyoto T cell Conference
- Place of Presentation
  京都府京都市
- Year and Date
  2014-05-17
- Data Source
  KAKENHI-PROJECT-26460569
[Presentation] Functionally distinct GATA3 complexes regulate Th2 cell differentiation and proliferation.2014
- Author(s)
  細川裕之、加藤美紀、中山俊憲
- Organizer
  第24回Kyoto T cell Conference
- Place of Presentation
  京都府京都市
- Year and Date
  2014-05-17
- Data Source
  KAKENHI-PROJECT-26460569
[Presentation] Epigenetic regulation of helper T cells by Polycomb and Trithorax complexes2013
- Author(s)
  Onodera, A., Horiuchi, S., Sasaki, T., Hosokawa, H., Watanabe, Y., Suzuki, Y., and Nakayama, T.
- Organizer
  International Symposium on Genome Science
- Place of Presentation
  Tokyo
- Year and Date
  2013-01-09
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] 中山俊憲GATA3/Ruvbl2複合体によるCdkn2c(p18,Ink4c)の転写制御を介したTh2細胞増殖制御メカニズムの解析2012
- Author(s)
  細川裕之、田中知明、加藤美紀、遠山裕之、鈴木茜
- Organizer
  第22回Kyoto T cell Conference
- Place of Presentation
  京都
- Year and Date
  2012-07-07
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] CD69 regulates the formationof resting T-helper memory2012
- Author(s)
  Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Hosokawa, H., Iwamura, C., Koseki, H., Tumes, D., Radbruch, A., and Nakayama, T.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2012-12-06
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] Genome-wide gene expression profiling revealed a critical role for GATA3 inthe maintenance of the Th2 cell phenotype2012
- Author(s)
  Sasaki, T., Onodera, A., Hosokawa, H., Watanabe, Y., Horiuchi, S., Yamashita, J., and Nakayama, T.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2012-12-05
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] GATA3 ChIP-sequence解析を用いたTh2特異的遺伝子の転写調節機構の解明/ Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3.2011
- Author(s)
  堀内周、小野寺淳、細川裕之、渡邊友紀子、中山俊憲
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] Eomesodermin controls IL-5 production in memory Th2 cells through the inhibition of GATA3 activity.2011
- Author(s)
  遠藤裕介、小野寺淳、細川裕之、中山俊憲
- Organizer
  第21回Kyoto T Cell Conference
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] マウス Schnurri-2 は NK細胞の機能とリンパ腫の発症を制御する/Murine Schnurri-2 controls Natural Killer cell function and lymphoma development2011
- Author(s)
  Yamashita, J., Iwamura, C., Hosokawa, H., Sasaki, T., Tumes, D., Motohashi, S., and Nakayama, T.
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] 肺炎球菌の血流感染及び肺炎における、IL-13による宿主防御の役割/ Protective role of IL-13 in sepsis and respiratory infection against S. pneumoniae.2011
- Author(s)
  Yamamoto, N., DelaCruz, C., Takahashi, M., Fujita, T., Hosokawa, H., Nakayama, T., Akahori, Y., Yamamoto, H., Kawakami, K., Askenase, W. P., and Kanemitsu, K
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] 肺炎球菌の血流感染及び肺炎における、IL-13による宿主防御の役割/Protective role of IL-13 in sepsis and respiratory infection against S. pneumoniae2011
- Author(s)
  Yamamoto, N., DelaCruz, C., Takahashi, M., Fujita, T., Hosokawa, H., Nakayama, T., Akahori, Y., Yamamoto, H., Kawakami, K.,Askenase, W. P., and Kanemitsu, K.
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] STAT6によって誘導されるポリコ-ムとトライソラックスの置換反応/STAT6-mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance of GATA3 expression in Th2 cells2011
- Author(s)
  Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Horiuchi, S., Watanabe, Y., and Nakayama, T.
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] STAT6によって誘導されるポリコ－ムとトライソラックスのー置換反応/ STAT6-mediated displacement of Polycomb by Trithorax complex establishes long-term maintenance of GATA3 expression in Th2 cells.2011
- Author(s)
  Onodera, A., Yamashita, M., Endo, Y., Kuwahara, M., Tofukuji, S., Hosokawa, H., Horiuchi, S., Watanabe, Y., and Nakayama, T.
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] マウスSchnurri-2はNK細胞の機能とリンパ腫の発症を制御する/ Murine Schnurri-2 controls Natural Killer cell function and lymphoma development.2011
- Author(s)
  Yamashita, J., Iwamura, C., Hosokawa, H., Sasaki, T., Tumes, D., Motohashi, S., and Nakayama, T.
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] Transcription factor MLL regulates IL-4 mediated anti-tumor response by tumor specific memory Th2 cells2009
- Author(s)
  Hosokawa, H
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20790367
[Presentation] Regulation of memory Th cell survival and function by the polycomb and trithorax group gene products.2009
- Author(s)
  Nakayama, T., Hosokawa, H.
- Organizer
  The 5th International Workshop of Kyoto T Cell Conference 2009
- Place of Presentation
  京都
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20790367
[Presentation] Transcription factor MLL regulates IL-4 mediated anti -tumor response by tumor specific memory Th2 cells2009
- Author(s)
  Hosokawa, H.
- Organizer
  39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-20790367
[Presentation] Lymphoid enhancer factor 1(LEF1)はGATA3に会合しその機能を調節する/Lymphoid enhancer factor interacts with GATA3 and controls its function in T helper type 2 cells2008
- Author(s)
  細川裕之
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790367
[Presentation] BCG Tokyo-172から分離精製したLAM/LM分子によるHuman Th1分化誘導機構/Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172.2008
- Author(s)
  Ito, T., Hosokawa, H.
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-20790367
[Presentation] Bmi1はNoxa遺伝子の発現抑制を介してメモリーTh細胞の生存を制御する/Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene.2008
- Author(s)
  Yamashita, M., Hosokawa, H.
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20790367
[Presentation] Lymphoid enhancer factor 1 (LEF1)はGATA3に会合しその機能を調節する/Lymphoid enhancer factor interacts with GATA3 and controls its function in T helper type 2 cells2008
- Author(s)
  細川裕之
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-20790367
[Presentation] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3.2007
- Author(s)
  Hosokawa, H.
- Organizer
  Chromatin Structure & Function
- Place of Presentation
  Antigua
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390139
[Presentation] Regulation of Th2 cell development by Polycomb group genebmi-1 through the stabilization of GATA32007
- Author(s)
  Hosokawa, H.
- Organizer
  Chromatin Structure & Function, 2007
- Place of Presentation
  Andgua
- Data Source
  KAKENHI-PROJECT-18890046
[Presentation] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA32007
- Author(s)
  Hosokawa, H.
- Organizer
  Chromatin Structure & Function
- Place of Presentation
  Antigua
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390139
[Presentation] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA32007
- Author(s)
  Hosokawa, H.
- Organizer
  Chromathin Structure & Function
- Place of Presentation
  Antigua
- Data Source
  KAKENHI-PROJECT-17390139
[Presentation] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA32006
- Author(s)
  Hosokawa, H.
- Organizer
  The 36th Annual meeting of the Japanese Society for Immunology
- Place of Presentation
  Osaka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390139
[Presentation] Regulation of Th2 cell development by Polycomb group gene bmi-1 through the stabilization of GATA3.2006
- Author(s)
  Hosokawa, H.
- Organizer
  第36回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390139
[Presentation] GATA3/Ruvbl2複合体によるCdkn2c (p18, Ink4c)の転写制御を介したTh2細胞増殖制御メカニズムの解析
- Author(s)
  細川裕之、田中知明、加藤美紀、遠山裕之、鈴木茜、中山俊憲
- Organizer
  Kyoto T cell Conference
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] Genome-wide gene expression profiling revealed a critical role for GATA3 in the maintenance of the Th2 cell phenotype.
- Author(s)
  Sasaki, T., Onodera, A., Hosokawa, H., Watanabe, Y., Horiuchi, S., Yamashita, J., and Nakayama, T.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] CD69 regulates the formation of resting T-helper memory.
- Author(s)
  Shinoda, K., Tokoyoda, K., Hanazawa, A., Hayashizaki, K., Hosokawa, H., Iwamura, C., Koseki, H., Tumes, D., Radbruch, A., and Nakayama, T.
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23790522
[Presentation] Epigenetic regulation of helper T cells by Polycomb and Trithorax complexes.
- Author(s)
  Onodera A., Horiuchi S., Sasaki T., Hosokawa H., Watanabe Y., Suzuki Y., Nakayama T.
- Organizer
  International Symposium on Genome Science
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790522

1. NAKAYAMA Toshinori (50237468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. 遠藤裕介 (80612192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. MORO Kazuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 今井仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 田中知明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 中山哲俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 佐久間一基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 平野健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosokawa Hiroyuki 細川 裕之

HOSOKAWA HIROYUKI 細川 裕之

細川 裕之 ホソカワ ヒロユキ

HOSOKAWA Hiroyuki 細川 裕之

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Research Products

Co-Researchers

Notch-dependent functional conversion of RUNX transcription factors regulates the initiation of T-lineage programPrincipal Investigator

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Are the cell-type specific actions of master transcription factors controlled by the organization of functional protein complexes?Principal Investigator

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Stage-specific roles of Notch signaling on induction of T cell development from hematopoietic progenitor cellsPrincipal Investigator

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活性型/抑制型GATA3複合体の形成と制御メカニズムの解明Principal Investigator

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Functions of posttranscriptional regulation of GATA3 in Th2 cellsPrincipal Investigator

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Identification of the functional molecular complexes of GATA3 in Th2 cells.Principal Investigator

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ポリコーム群遺伝子Bmi-1によるGATA3のタンパク質安定性制御機構の解明Principal Investigator

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Regulation of chromatin remodeling in differentiation and maintenance of Th1/Th2 cells

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[Book] 医学のあゆみ2014

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[Journal Article] GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma2022

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[Journal Article] Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis2022

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[Journal Article] Transcription factor Zbtb1 interacts with bridging factor Lmo2 and maintains the T-lineage differentiation capacity of lymphoid progenitor cells2022

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[Journal Article] Transcription factors regulate early T?cell development via redeployment of other factors2021

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[Journal Article] Notch signaling supports the appearance of follicular helper T cells in the Peyer's patches concomitantly with the reduction of regulatory T cells2021

Hosokawa Hiroyuki 細川裕之

HOSOKAWA HIROYUKI 細川裕之

細川裕之ホソカワヒロユキ

HOSOKAWA Hiroyuki 細川裕之