Nagashima Shigeo 長嶋茂雄

… Alternative Names

NAGASHIMA Mshigeo 長嶋茂雄

NAGASHIMA Shigeo 長嶋茂雄

Less

Researcher Number	60433116
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2023: 自治医科大学, 医学部, 准教授 2016 – 2022: 自治医科大学, 医学部, 講師 2010 – 2014: 自治医科大学, 医学部, 講師 2010: 札幌医科大学, 医学部, 助教 2007 – 2008: Sapporo Medical University, School of Medicine Department of Hygiene, School of Medicine Department of Hygiene
Review Section/Research Field	Principal Investigator Virology / Basic Section 49060:Virology-related Except Principal Investigator Hygiene / Virology
Keywords	Principal Investigator E型肝炎ウイルス / エクソソーム / 粒子形成 / 感染感受性 / 細胞内侵入 / 受容体 / 感染初期過程 / エンベロープ / 放出 / 増殖抑制 … More / スクリーニング / 化合物 / レポーターアッセイ / HiBiTタグ / ライフサイクル / 薬剤スクリーニング / ウイルス放出 / 生物発光タンパク質 / レプリコン / レポーターウイルス / 許容性 / 細胞間伝播 / 感染許容性 / 細胞内輸送 / マイクロアレイ / 細胞侵入 / エクソソーム分泌経路 / 出芽 / 多胞体 / ESCRT機構 / MVB経路 / エンドソーム輸送 / Vps4 / Tsg101 / MVB 経路 / E 型肝炎ウイルス … More Except Principal Investigator 分子疫学 / multidrug efflux pump / molecular epidemiology / resistance gene / antiseptics / enterococcus / 型別 / 浸淫状況 / 消毒済 / 多剤排出蛋白 / 耐性遺伝子 / 消毒剤 / 腸球菌 / MVB sorting / 放出機構 / Tsg101 / PSAPモチーフ / ORF3蛋白質 / ゲノム変異 / 劇症肝炎 / 感染性cDNAクローン / 細胞レセプター候補分子 / 吸着 / 感受性細胞 / 感染性 cDNA クローン / 感染培養系 / E型肝炎ウイルス / 市中感染 / コアグラーゼ型 / MLST / スタフィロコアグラーゼ / 遺伝子型 / PVL / MRSA / 黄色ブドウ球菌 / 下痢 / プロテオーム / 生理学 / 熱帯地域 / B群 / B 群 / 新興型 / アジア / 下痢症 / 成人 / 新種 / ロタウイルス Less

Identification of compounds that inhibit the early and late steps of hepatitis E virus infection and analysis of their inhibitory effects on the virus growthPrincipal Investigator
- Principal Investigator
  
  長嶋茂雄
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Jichi Medical University
Functional evaluation of the candidate proteins of hepatitis E virus receptor and identification of host factors involved in the permissibility of infectionPrincipal Investigator
- Principal Investigator
  
  Nagashima Shigeo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Jichi Medical University
Identification and functional analysis of host factors involved in early steps of hepatitis E virus infectionPrincipal Investigator
- Principal Investigator
  
  Nagashima Shigeo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Research on mechanism of hepatitis E virus egress utilizing membrane trafficPrincipal Investigator
- Principal Investigator
  
  NAGASHIMA Shigeo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particlesPrincipal Investigator
- Principal Investigator
  
  NAGASHIMA Shigeo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEV
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Study on prevalence of PVL-positive Staphylococcus aureus and MRSA with the use of novel molecular epidemiologic methods
- Principal Investigator
  
  KOBAYASHI Nobumichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Sapporo Medical University
Study of characteristics and prevalence of novel species rotavirus detected in Asia
- Principal Investigator
  
  KOBAYASHI Nobumichi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Sapporo Medical University
外来病原因子による下痢発症生理におけるプロテオーム解析
- Principal Investigator
  
  石埜正穂
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hygiene
- Research Institution
  Sapporo Medical University
Identification and prevalence of antiseptip resistance genes in enterococci
- Principal Investigator
  
  KOBAYAHI Nobumichi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Sapporo Medical University

[Journal Article] Chronic hepatitis E in an elderly immunocompetent patient who achieved a sustained virologic response with ribavirin treatment2023
- Author(s)
  Takakusagi Satoshi、Takagi Hitoshi、Yamazaki Yuichi、Kosone Takashi、Nagashima Shigeo、Takahashi Masaharu、Murata Kazumoto、Okamoto Hiroaki
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 16 Issue: 2 Pages: 206-215
- DOI
  10.1007/s12328-022-01733-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07105
[Journal Article] Development of a HiBiT-tagged reporter hepatitis E virus and its utility as an antiviral drug screening platform2023
- Author(s)
  Nagashima Shigeo、Primadharsini Putu Prathiwi、Nishiyama Takashi、Takahashi Masaharu、Murata Kazumoto、Okamoto Hiroaki
- Journal Title
  
  Journal of Virology
  
  Volume: 97 Issue: 9
- DOI
  10.1128/jvi.00508-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07105, KAKENHI-PROJECT-22K07991, KAKENHI-PROJECT-22K15478
[Journal Article] Development and Characterization of Efficient Cell Culture Systems for Genotype 1 Hepatitis E Virus and Its Infectious cDNA Clone2023
- Author(s)
  Primadharsini Putu Prathiwi、Nagashima Shigeo、Tanaka Toshinori、Jirintai Suljid、Takahashi Masaharu、Murata Kazumoto、Okamoto Hiroaki
- Journal Title
  
  Viruses
  
  Volume: 15 Issue: 4 Pages: 845-845
- DOI
  10.3390/v15040845
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07105, KAKENHI-PROJECT-22K15478, KAKENHI-PROJECT-22K07991
[Journal Article] Three Distinct Reporter Systems of Hepatitis E Virus and Their Utility as Drug Screening Platforms2023
- Author(s)
  Primadharsini Putu Prathiwi、Nagashima Shigeo、Nishiyama Takashi、Okamoto Hiroaki
- Journal Title
  
  Viruses
  
  Volume: 15 Issue: 10 Pages: 1989-1989
- DOI
  10.3390/v15101989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07105, KAKENHI-PROJECT-22K15478
[Journal Article] Infection Dynamics and Genomic Mutations of Hepatitis E Virus in Naturally Infected Pigs on a Farrow-to-Finish Farm in Japan: A Survey from 2012 to 20212023
- Author(s)
  Takahashi Masaharu、Kunita Satoshi、Nishizawa Tsutomu、Ohnishi Hiroshi、Primadharsini Putu Prathiwi、Nagashima Shigeo、Murata Kazumoto、Okamoto Hiroaki
- Journal Title
  
  Viruses
  
  Volume: 15 Issue: 7 Pages: 1516-1516
- DOI
  10.3390/v15071516
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07105, KAKENHI-PROJECT-22K07991, KAKENHI-PROJECT-22K15478
[Journal Article] First detection and characterization of rat hepatitis E Virus (HEV-C1) in Japan2022
- Author(s)
  Takahashi Masaharu、Kunita Satoshi、Kawakami Manri、Kadosaka Teruki、Fujita Hiromi、Takada Nobuhiro、Miyake Masao、Kobayashi Tominari、Ohnishi Hiroshi、Nagashima Shigeo、Murata Kazumoto、Okamoto Hiroaki
- Journal Title
  
  Virus Research
  
  Volume: 314 Pages: 198766-198766
- DOI
  10.1016/j.virusres.2022.198766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07105
[Journal Article] Ritonavir Blocks Hepatitis E Virus Internalization and Clears Hepatitis E Virus In Vitro with Ribavirin2022
- Author(s)
  Primadharsini Putu Prathiwi、Nagashima Shigeo、Takahashi Masaharu、Murata Kazumoto、Okamoto Hiroaki
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 11 Pages: 2440-2440
- DOI
  10.3390/v14112440
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07105, KAKENHI-PROJECT-22K07991, KAKENHI-PROJECT-22K15478
[Journal Article] Identification of hepatitis E virus in wild sika deer in Japan2022
- Author(s)
  Takahashi Masaharu、Nishizono Akira、Kawakami Manri、Fukui Emiko、Isogai Emiko、Matsuoka Hiroyuki、Yamamoto Seigo、Mizuo Hitoshi、Nagashima Shigeo、Murata Kazumoto、Okamoto Hiroaki
- Journal Title
  
  Virus Research
  
  Volume: 308 Pages: 198645-198645
- DOI
  10.1016/j.virusres.2021.198645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07579
[Journal Article] Development of Recombinant Infectious Hepatitis E Virus Harboring the nanoKAZ Gene and Its Application in Drug Screening2022
- Author(s)
  Primadharsini Putu Prathiwi、Nagashima Shigeo、Nishiyama Takashi、Takahashi Masaharu、Murata Kazumoto、Okamoto Hiroaki
- Journal Title
  
  Journal of Virology
  
  Volume: 96 Issue: 6
- DOI
  10.1128/jvi.01906-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07579, KAKENHI-PROJECT-20K22771
[Journal Article] Subclinical hepatitis E virus (HEV) infection detected by nucleic acid amplification test on blood donation: short-term positivity for immunoglobulin G class of antibody against HEV2022
- Author(s)
  Hasegawa Izumi、Nakano Tatsunori、Koguchi Hiroki、Jinno Naruomi、Hirashima Noboru、Nagashima Shigeo、Takahashi Masaharu、Murata Kazumoto、Okamoto Hiroaki
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 15 Issue: 4 Pages: 750-754
- DOI
  10.1007/s12328-022-01635-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07105, KAKENHI-PROJECT-22K07991
[Journal Article] Identification and a full genome analysis of novel camel hepatitis E virus strains obtained from Bactrian camels in Mongolia2021
- Author(s)
  Nishizawa Tsutomu、Takahashi Masaharu、Tsatsralt-Od Bira、Nyamdavaa Khurelbaatar、Dulmaa Nyamkhuu、Osorjin Byankhuu、Tseren-Ochir Erdene-Ochir、Sharav Tumenjargal、Bayasgalan Chimedtseren、Sukhbaatar Boldbaatar、Nagashima Shigeo、Murata Kazumoto、Okamoto Hiroaki
- Journal Title
  
  Virus Research
  
  Volume: 299 Pages: 198355-198355
- DOI
  10.1016/j.virusres.2021.198355
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07579
[Journal Article] Mechanism of Cross-Species Transmission, Adaptive Evolution and Pathogenesis of Hepatitis E Virus2021
- Author(s)
  Primadharsini Putu Prathiwi、Nagashima Shigeo、Okamoto Hiroaki
- Journal Title
  
  Viruses
  
  Volume: 13 Issue: 5 Pages: 909-909
- DOI
  10.3390/v13050909
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07579, KAKENHI-PROJECT-20K22771
[Journal Article] Production of capsid proteins of rat hepatitis E virus in Escherichia coli and characterization of self-assembled virus-like particles2021
- Author(s)
  Kobayashi Tominari、Takahashi Masaharu、Ohta Satoshi、Nagashima Shigeo、Primadharsini Putu Prathiwi、Mulyanto、Kunita Satoshi、Murata Kazumoto、Okamoto Hiroaki
- Journal Title
  
  Virus Research
  
  Volume: 302 Pages: 198483-198483
- DOI
  10.1016/j.virusres.2021.198483
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07579, KAKENHI-PROJECT-20K22771
[Journal Article] A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis in Heart and Kidney Transplant Recipients in Japan2020
- Author(s)
  Owada Y, Oshiro Y, Inagaki Y, Harada H, Fujiyama N, Kawagishi N, Yagisawa T, Usui J, Akutsu N, Itabashi Y, Saito K, Watarai Y, Ichimaru N, Imamura R, Kyakuno M, Ide K, Shibuya Y, Okabe Y, Ono M, Sasaki K, Shiose A, Yamagishi K, Ohnishi H, Nagashima S, et al.
- Journal Title
  
  Transplantation
  
  Volume: 104 Issue: 2 Pages: 437-444
- DOI
  10.1097/tp.0000000000002801
- NAID
  120007132798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07579
[Journal Article] IFN-λ3 as a host immune response in acute hepatitis E virus infection2020
- Author(s)
  Murata K, Kang JH, Nagashima S, Matsui T, Karino Y, Yamamoto Y, Atarashi T, Oohara M, Uebayashi M, Sakata H, Matsubayashi K, Takahashi K, Arai M, Mishiro S, Sugiyama M, Mizokami M, Okamoto H.
- Journal Title
  
  Cytokine
  
  Volume: 125 Pages: 154816-154816
- DOI
  10.1016/j.cyto.2019.154816
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07579, KAKENHI-PROJECT-17K09448
[Journal Article] Multivesicular body sorting and the exosomal pathway are required for the release of rat hepatitis E virus from infected cells2020
- Author(s)
  Primadharsini PP, Nagashima S, Takahashi M, Kobayashi T, Nishiyama T, Nishizawa T, Yasuda J, Mulyanto, Okamoto H.
- Journal Title
  
  Virus Research
  
  Volume: 278 Pages: 197868-197868
- DOI
  10.1016/j.virusres.2020.197868
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07579
[Journal Article] Prevalence and genotype/subtype distribution of hepatitis E virus (HEV) among wild boars in Japan: Identification of a genotype 5 HEV strain2020
- Author(s)
  Takahashi Masaharu、Nishizawa Tsutomu、Sato Yukihiro、Miyazaki Shinichi、Aikawa Tatsuya、Ashida Kozo、Tamaru Tomoko、Oguro Kunihiko、Hayakawa Fumihiro、Matsuoka Hiroyuki、Ozaki Hideaki、Kodera Yuuji、Irokawa Masahiko、Hirose Hideo、Nagashima Shigeo、Kawakami Manri、Mizuo Hitoshi、Okamoto Hiroaki、Murata Kazumoto
- Journal Title
  
  Virus Research
  
  Volume: 287 Pages: 198106-198106
- DOI
  10.1016/j.virusres.2020.198106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07579
[Journal Article] Clinical and virologic features of hepatitis E virus infection at a university hospital in Japan between 2000 and 20192020
- Author(s)
  Sato Naoto、Watanabe Shunji、Miura Kouichi、Morimoto Naoki、Takaoka Yoshinari、Nomoto Hiroaki、Isoda Norio、Nagashima Shigeo、Takahashi Masaharu、Okamoto Hiroaki、Yamamoto Hironori
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 92 Issue: 12 Pages: 3572-3583
- DOI
  10.1002/jmv.26248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07579
[Journal Article] The spontaneous clearance of hepatitis E virus (HEV) and emergence of HEV antibodies in a transfusion-transmitted chronic hepatitis E case after completion of chemotherapy for acute myeloid leukemia2020
- Author(s)
  Okano H, Nakano T, Ito R, Tanaka A, Hoshi Y, Matsubayashi K, Asakawa H, Nose K, Tsuruga S, Tochio T, Kumazawa H, Isono Y, Tanaka H, Matsusaki S, Sase T, Saito T, Mukai K, Nishimura A, Kawakami K, Nagashima S, et al.
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 13 Issue: 2 Pages: 252-259
- DOI
  10.1007/s12328-019-01024-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07579
[Journal Article] Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitro2019
- Author(s)
  Nishiyama T, Kobayashi T, Jirintai S, Nagashima S, Primadharsini PP, Nishizawa T, Okamoto H.
- Journal Title
  
  Antiviral Research
  
  Volume: 170 Pages: 104570-104570
- DOI
  10.1016/j.antiviral.2019.104570
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07579
[Journal Article] Changing clinical and molecular characteristics of hepatitis E virus infection in Mie Prefecture, Japan: Disappearance of indigenous subtype 3e strains2019
- Author(s)
  Nakano T, Okano H, Takahashi M, Nagashima S, Shiraki K, Oya Y, Inoue H, Ohmori S, Tsukimoto M, Satoshi I, Fujimoto S, Kobayashi M, Yamawaki M, Kumagai M, Ninomiya J, Maekawa T, Kojima Y, Araki J, Hamaoka S, Horiike S, Yoshimura H, Takeuchi K, Itoh K, Akachi S, Uraki S, Yamamoto N, Ogura S, Sugimoto K, et al.
- Journal Title
  
  Hepatology Research
  
  Volume: 49 Issue: 9 Pages: 1003-1014
- DOI
  10.1111/hepr.13357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07579
[Journal Article] Genetic Variability and Evolution of Hepatitis E Virus2019
- Author(s)
  Primadharsini PP, Nagashima S, Okamoto H.
- Journal Title
  
  Viruses
  
  Volume: 11 Issue: 5 Pages: 456-456
- DOI
  10.3390/v11050456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07579
[Journal Article] Screening of novel drugs for inhibiting hepatitis E virus replication2019
- Author(s)
  Nishiyama T, Kobayashi T, Jirintai S, Kii I, Nagashima S, Primadharsini PP, Nishizawa T, Okamoto H.
- Journal Title
  
  Journal of Virological Methods
  
  Volume: 270 Pages: 1-11
- DOI
  10.1016/j.jviromet.2019.04.017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07579, KAKENHI-PROJECT-19H02856
[Journal Article] Hepatitis E virus subtype 3f strains isolated from Japanese hepatitis patients with no history of travel to endemic areas ? The origin analyzed by molecular evolution2018
- Author(s)
  Nakano Tatsunori、Takahashi Masaharu、Takahashi Kazuaki、Nagashima Shigeo、Suzuki Yusuke、Nishigaki Yoichi、Tomita Eiichi、Okano Hiroshi、Oya Yumi、Shiraki Katsuya、Takase Kojiro、Sugimoto Kazushi、Koyama Junichi、Mizuo Hitoshi、Ikezawa Kazuto、Aikawa Tatsuya、Arai Masahiro、Okamoto Hiroaki
- Journal Title
  
  Virology
  
  Volume: 513 Pages: 146-152
- DOI
  10.1016/j.virol.2017.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08817
[Journal Article] An analysis of two open reading frames (ORF3 and ORF4) of rat hepatitis E virus genome using its infectious cDNA clones with mutations in ORF3 or ORF42018
- Author(s)
  Tanggis、Kobayashi Tominari、Takahashi Masaharu、Jirintai Suljid、Nishizawa Tsutomu、Nagashima Shigeo、Nishiyama Takashi、Kunita Satoshi、Hayama Emiko、Tanaka Takeshi、Mulyanto、Okamoto Hiroaki
- Journal Title
  
  Virus Research
  
  Volume: 249 Pages: 16-30
- DOI
  10.1016/j.virusres.2018.02.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19144, KAKENHI-PROJECT-16K08817
[Journal Article] Characterization of the Quasi-Enveloped Hepatitis E Virus Particles Released by the Cellular Exosomal Pathway2017
- Author(s)
  Nagashima Shigeo、Takahashi Masaharu、Kobayashi Tominari、Nishizawa Tsutomu、Nishiyama Takashi、Primadharsini Putu Prathiwi、Okamoto Hiroaki、Tanggis
- Journal Title
  
  Journal of Virology
  
  Volume: 91 Issue: 22
- DOI
  10.1128/jvi.00822-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08817, KAKENHI-PROJECT-16K19144
[Journal Article] Full-length genome of a novel genotype 3 hepatitis E virus strain obtained from domestic pigs in Japan2017
- Author(s)
  Primadharsini PP, Miyake M, Kunita S, Nishizawa T, Takahashi M, Nagashima S, Tanggis, Ohnishi H, Kobayashi T, Nishiyama T, Jirintai S, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 240 Pages: 147-153
- DOI
  10.1016/j.virusres.2017.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08817, KAKENHI-PROJECT-16K19144
[Journal Article] Full-length genomic sequences of new subtype 1g hepatitis E virus strains obtained from four patients with imported or autochthonous acute hepatitis E in Japan2017
- Author(s)
  Nishizawa Tsutomu、Primadharsini Putu Prathiwi、Namikawa Masashi、Yamazaki Yuichi、Uraki Satoko、Okano Hiroshi、Horiike Shinichiro、Nakano Tatsunori、Takaki Shintaro、Kawakami Manri、Nagashima Shigeo、Takahashi Masaharu、Okamoto Hiroaki
- Journal Title
  
  Infection, Genetics and Evolution
  
  Volume: 55 Pages: 343-349
- DOI
  10.1016/j.meegid.2017.10.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08817
[Journal Article] Clinical and virological features of acute hepatitis E in Gunma prefecture, Japan between 2004 and 2015.2017
- Author(s)
  Yamazaki Y, Naganuma A, Arai Y, Takeuchi S, Kobayashi T, Takakusagi S, Hatanaka T, Hoshino T, Namikawa M, Hashizume H, Takizawa D, Ohyama T, Suzuki H, Horiguchi N, Takagi H, Sato K, Kakizaki S, Kusano M, Nagashima S, Takahashi M, Okamoto H, Yamada M.
- Journal Title
  
  Hepatology Research
  
  Volume: 47 Issue: 5 Pages: 435-445
- DOI
  10.1111/hepr.12765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08817
[Journal Article] Full-length genomic sequence analysis of new subtype 3k hepatitis E virus isolates with 99.97% nucleotide identity obtained from two consecutive acute hepatitis patients in a city in northeast Japan2017
- Author(s)
  Miura Masahito、Inoue Jun、Tsuruoka Mio、Nishizawa Tsutomu、Nagashima Shigeo、Takahashi Masaharu、Shimosegawa Tooru、Okamoto Hiroaki
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 89 Issue: 6 Pages: 1116-1120
- DOI
  10.1002/jmv.24743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08817
[Journal Article] Autochthonous sporadic acute hepatitis E caused by two distinct subgenotype 3b hepatitis E virus strains with only 90% nucleotide identity2017
- Author(s)
  Yamaguchi Yasuko、Takagi Hitoshi、Suzuki Yuhei、Maruhashi Kyoko、Kosone Takashi、Kakizaki Satoru、Sato Ken、Yamada Masanobu、Nagashima Shigeo、Takahashi Masaharu、Okamoto Hiroaki
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 10 Issue: 2 Pages: 168-173
- DOI
  10.1007/s12328-017-0718-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08817
[Journal Article] Distinct changing profiles of hepatitis A and E virus infection among patients with acute hepatitis in Mongolia: The first report of the full genome sequence of a novel genotype 1 hepatitis E virus strain2017
- Author(s)
  Tsatsralt-Od Bira、Primadharsini Putu Prathiwi、Nishizawa Tsutomu、Ohnishi Hiroshi、Nagashima Shigeo、Takahashi Masaharu、Jirintai Suljid、Nyamkhuu Dulmaa、Okamoto Hiroaki
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 90 Issue: 1 Pages: 84-92
- DOI
  10.1002/jmv.24907
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08817
[Journal Article] Production of monoclonal antibodies against the ORF3 protein of rat hepatitis E virus (HEV) and demonstration of the incorporation of the ORF3 protein into enveloped rat HEV particles.2016
- Author(s)
  Takahashi M, Kobayashi T, Tanggis, Jirintai S, Mulyanto, Nagashima S, Nishizawa T, Kunita S, Okamoto H.
- Journal Title
  
  Archives of Virology
  
  Volume: 161 Pages: 3391-3404
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08817
[Journal Article] Characterization and epitope mapping of monoclonal antibodies raised against rat hepatitis E virus capsid protein: An evaluation of their neutralizing activity in a cell culture system.2016
- Author(s)
  Kobayashi T, Takahashi M, Tanggis, Mulyanto, Jirintai S, Nagashima S, Nishizawa T, Okamoto H.
- Journal Title
  
  Journal of Virological Methods
  
  Volume: 233 Pages: 78-88
- DOI
  10.1016/j.jviromet.2016.03.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08817, KAKENHI-PROJECT-16K19144
[Journal Article] Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone.2016
- Author(s)
  Nagashima S, Kobayashi T, Tanaka T, Tanggis, Jirintai S, Takahashi M, Nishizawa T, Okamoto H.
- Journal Title
  
  Virus Research
  
  Volume: 223 Pages: 170-180
- DOI
  10.1016/j.virusres.2016.07.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08817, KAKENHI-PROJECT-16K19144
[Journal Article] The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 22014
- Author(s)
  Nagashima S, Takahashi M, Jirintai S, Tanggis, Kobayashi T, Nishizawa T, Okamoto H
- Journal Title
  
  Archives of Virology
  
  Volume: 159 Issue: 5 Pages: 979-991
- DOI
  10.1007/s00705-013-1912-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines2014
- Author(s)
  Jirintai S, Tanggis, Mulyanto, Suparyatmo JB, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 185 Pages: 92-102
- DOI
  10.1016/j.virusres.2014.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains2014
- Author(s)
  Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Kawakami M, Sonoda Y, Suzuki T, Yamamoto S, Shigemoto K, Ashida K, Sato Y, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 180 Pages: 59-69
- DOI
  10.1016/j.virusres.2013.12.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] Characterization of sporadic acute hepatitis E and comparison of hepatitis E virus genomes in acute hepatitis patients and pig liver sold as food in Mie, Japan2014
- Author(s)
  Okano H, Takahashi M, Isono Y, Tanaka H, Nakano T, Oya Y, Sugimoto K, Ito K, Ohmori S, Maegawa T, Kobayashi M, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Hepatology Research
  
  Volume: 印刷中 Issue: 10
- DOI
  10.1111/hepr.12216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies2014
- Author(s)
  Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Kouki T, Yashiro T, Okamoto H
- Journal Title
  
  Journal of General Virology
  
  Volume: 95 Issue: 10 Pages: 2166-2175
- DOI
  10.1099/vir.0.066910-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis2014
- Author(s)
  Mulyanto, Suparyatmo JB, Andayani IG, Khalid, Takahashi M, Ohnishi H, Jirintai S, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 179 Pages: 102-112
- DOI
  10.1016/j.virusres.2013.10.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan2013
- Journal Title
  
  Hepatol Res
  
  Volume: 印刷中 Issue: 6 Pages: 694-699
- DOI
  10.1111/hepr.12155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-25860343
[Journal Article] Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia2013
- Author(s)
  Mulyanto
- Journal Title
  
  Archives of Virology
  
  Volume: 158 Issue: 1 Pages: 87-96
- DOI
  10.1007/s00705-012-1462-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia2013
- Author(s)
  Mulyanto, Depamede SN, Sriasih M, Takahashi M, Nagashima S, Jirintai S, Nishizawa T, Okamoto H
- Journal Title
  
  Arch Virol
  
  Volume: 158(1) Pages: 87-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells2012
- Author(s)
  D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Res
  
  Volume: 170(1-2) Pages: 126-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains : demonstration of HEV infectivity of porcine liver sold as food2012
- Author(s)
  Takahashi H
- Journal Title
  
  Archives of Virology
  
  Volume: 157 Issue: 2 Pages: 235-246
- DOI
  10.1007/s00705-011-1153-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food2012
- Author(s)
  Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Mizuo H, Yazaki Y, Okamoto H
- Journal Title
  
  Arch Virol
  
  Volume: 157(2) Pages: 235-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells2012
- Author(s)
  Jirintai S
- Journal Title
  
  Virus Research
  
  Volume: 170 Issue: 1-2 Pages: 126-137
- DOI
  10.1016/j.virusres.2012.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions2011
- Author(s)
  Nagashima S
- Journal Title
  
  Journal of General Virology
  
  Volume: 92 Issue: 12 Pages: 2838-2848
- DOI
  10.1099/vir.0.035378-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions.2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai S, Tanaka T, Nishizawa T, Yasuda J, Okamoto H.
- Journal Title
  
  J Gen Virol
  
  Volume: 92(Pt 12) Pages: 2838-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes2011
- Author(s)
  Sato Y, Sato H, Naka K, Furuya S, Tsukiji H, Kitagawa K, Sonoda Y, Usui T, Sakamoto H, Yoshino S, Shimizu Y, Takahashi M, Nagashima S, Jirintai, Nishizawa T, Okamoto H.
- Journal Title
  
  Arch Virol
  
  Volume: 156(8) Pages: 1345-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype2011
- Author(s)
  Takahashi M, Nishizawa T, Sato H, Sato Y, Jirintai, Nagashima S, Okamoto H
- Journal Title
  
  J Gen Virol
  
  Volume: 92(Pt 4) Pages: 902-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells.2011
- Author(s)
  Nagashima S
- Journal Title
  
  Journal of General Virology
  
  Volume: 92 Pages: 269-278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Yamada K, Nishizawa T, Okamoto H
- Journal Title
  
  J Gen Virol
  
  Volume: 92(Pt 2) Pages: 269-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Hepatitis E Virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation2010
- Author(s)
  Takahashi M, Tanaka T, Takahashi H, Hoshino Y, Nagashima S, Jirintai, Mizuo H, Yazaki Y, Takagi T, Azuma M, Kusano E, Isoda N, Sugano K, Okamoto H.
- Journal Title
  
  J Clin Microbiol
  
  Volume: 48(4) Pages: 1112-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A nationwide survey of hepatitis E virus infection in the general population of Japan2010
- Author(s)
  Takahashi M, Tamura K, Hoshino Y, Nagashima S, Yazaki Y, Mizuo H, Iwamoto S, Okayama M, Nakamura Y, Kajii E, Okamoto H.
- Journal Title
  
  J Med Virol
  
  Volume: 82(2) Pages: 271-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia2010
- Author(s)
  Jinshan, Jirintai, Manglai D, Takahashi M, Nagashima S, Okamoto H
- Journal Title
  
  China. Arch Virol
  
  Volume: 155(8) Pages: 1217-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Full genomic analysis of a human group A rotavirus G9P[6] strain from Eastern India provides evidence for porcine to human interspecies transmission2009
- Author(s)
  Mukherjee A, Dutta D, Ghosh S, Bagchi P, Chattopadhyay S, Nagashima S, Kobayashi N, Dutta P, Krishnan T, Naik TN, Chawla-Sarkar M.
- Journal Title
  
  Archives of Virology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406018
[Journal Article] Phylogenetic analysis of rotaviruses with predominant G3 and emerging G9 genotypes from adults and children in Wuhan, China2009
- Author(s)
  Wang Y-H, Kobayashi N, Zhou X, Nagashima S, Zhu Z-R Peng J-S, Liu M-Q, Hu Q, Zhou D-J, Watanabe S, Ishino M.
- Journal Title
  
  Journal of Medical Virology 81
  
  Pages: 382-389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406018
[Journal Article] Diversity of staphylocoagulase and identification of novel variants of staphylocoagulase gene in Staphylococcus aureus2008
- Author(s)
  Kinoshita, M., Kobayashi, N., Nagashima, S., Ishino, M., Otokozawa, S., Mise, K., Sumi, A., Tsutsumi, H., Uehara, N., Watanabe, N., Endo, M
- Journal Title
  
  Microbiology and Immunology (in press)
- NAID
  10027684464
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590521
[Journal Article] Genetic characterization of Staphylococcus aureus isolates carrying Panton-Valentine leukocidin genes in Bangladesh.2008
- Author(s)
  Afroz S, Kobayashi N, Nagashima S, Alam MM, Hossain ABMB, Rahman A, Islam MR, Lutfor AB, Muazzam N, Khan MAH, Paul SK, Shamsuzzaman AKM, Mahmud MC, Musa AKM, Hossain MA.
- Journal Title
  
  Jpn J Infect Dis 61
  
  Pages: 393-396
- NAID
  40016249990
- Data Source
  KAKENHI-PROJECT-20590608
[Journal Article] Identical rearrangement of NSP3 genes found in three independently isolated virus clones derived from mixed infection and multiple passages of rotaviruses2008
- Author(s)
  Alam MM, Kobayashi N, Ishino M, Nagashima S, Paul SK, Chawla-Sarkar M, Krishnan T, Naik TN.
- Journal Title
  
  Arch Virol 153
  
  Pages: 555-559
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406018
[Journal Article] Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus Rotavirus.2008
- Author(s)
  Nagashima S, et al.
- Journal Title
  
  Journal of Medical Virology 80
  
  Pages: 2023-2033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406018
[Journal Article] Whole genomic characterization of a human rotavirus strain B219 belonging to a novel group of the genus Rotavirus2008
- Author(s)
  Nagashima S, Kobayashi N, Ishino M, Alam MM, Ahmed MU, Paul SK, Ganesh B, Chawla-Sarkar M, Krishnan T, Naik TN, Wang Y-H.
- Journal Title
  
  J Med Virol 80
  
  Pages: 2023-2033
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406018
[Journal Article] Phylogenetic analysis of rotaviruses with genotypes G1, G2, G9 and G12 in Bangladesh : evidence for a close relationship between rotaviruses from children and adults2008
- Author(s)
  Paul SK, Kobayashi N, Nagashima S, Ishino M, Watanabe S, Alam MM, Ahmed MU, Hossain MA, Naik TN.
- Journal Title
  
  Archives of Virology 153
  
  Pages: 1999-2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406018
[Journal Article] A high genomic similarity between European type hepatitis E virus subgenotype 3e Jirintai S, Jinshan, Tanggis, Manglai 18. strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan
- Author(s)
  Okano H, Nakano T, Sugimoto K, Takahashi K, Nagashima S, Takahashi M, Arai M, Okamoto H
- Journal Title
  
  Jinshan, Tanggis, Manglai
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] 3種類のE型肝炎ウイルス(HEV)レポーターシステムを利用した抗HEV薬スクリーニングの有用性の評価2023
- Author(s)
  長嶋茂雄、プトゥプラティウィプリマダルシニ、高橋雅春、村田一素、岡本宏明
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07105
[Presentation] 発光タグHiBiTを保有する組換えE型肝炎ウイルスの開発と薬剤スクリーニングへの応用2022
- Author(s)
  長嶋茂雄、プトゥプラティウィプリマダルシニ、西山尚志、高橋雅春、村田一素、岡本宏明
- Organizer
  第69回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07105
[Presentation] Functional analysis of a highly conserved YXXΦ motif in the ORF2 protein of hepatitis E virus2021
- Author(s)
  Shigeo Nagashima、Putu Prathiwi Primadharsini、Masaharu Takahashi、Hiroaki Okamoto、Kazumoto Murata
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07579
[Presentation] The tight junction protein ZO-1 is necessary for growth of hepatitis E virus in cultured cells2019
- Author(s)
  Shigeo Nagashima, Putu Prathiwi Primadharsini, Tominari Kobayashi, Masaharu Takahashi, Hiroaki Okamoto
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07579
[Presentation] Cathepsin L is required for entry step of hepatitis E virus2018
- Author(s)
  Shigeo Nagashima, Putu Prathiwi Primadharsini, Tominari Kobayashi, Masaharu Takahashi, Takashi Nishiyama, Tsutomu Nishizawa, Hiroaki Okamoto
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08817
[Presentation] Capsids of hepatitis E virus particles are individually covered by lipid membranes2017
- Author(s)
  Shigeo Nagashima, Masaharu Takahashi, Tominari Kobayashi, Tanggis, Putu Prathiwi Primadharsini, Takashi Nishiyama, Tsutomu Nishizawa, Hiroaki Okamoto
- Organizer
  第65回日本ウイルス学会学術集会大阪
- Data Source
  KAKENHI-PROJECT-16K08817
[Presentation] Cathepsin L is required for entry step of hepatitis E virus2017
- Author(s)
  Shigeo Nagashima, Masaharu Takahashi, Tominari Kobayashi, Tanggis, Tsutomu Nishizawa, Takashi Nishiyama, Putu Prathiwi Primadharsini, Hiroaki Okamoto
- Organizer
  International Union of Microbiological Societies 2017 Singapore
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08817
[Presentation] Characterization of hepatitis E virus cell entry2016
- Author(s)
  Shigeo Nagashima, Tominari Kobayashi, Tanggis, Masaharu Takahashi, Tsutomu Nishizawa, Hiroaki Okamoto
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-16K08817
[Presentation] E型肝炎ウイルスの細胞侵入・放出機構の解明2015
- Author(s)
  長嶋茂雄
- Organizer
  Liver Forum in Kyoto 第17回学術集会
- Place of Presentation
  京都（京都ホテルオークラ）
- Year and Date
  2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-25860343
[Presentation] 細胞内膜輸送系を利用したE型肝炎ウイルスの放出機構の解析2013
- Author(s)
  長嶋茂雄、高橋雅春、吉林台、小林富成、西澤勉、岡本宏明
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25860343
[Presentation] 培養細胞から放出された E 型肝炎ウイルスの粒子表面に存在する膜成分の抗原性の解析2012
- Author(s)
  長嶋茂雄、高橋雅春、吉林台、西澤勉、小林富成、岡本宏明
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-11-14
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] 培養細胞から放出されたE型肝炎ウイルスの粒子表面に存在する膜成分の抗原性の解析2012
- Author(s)
  長嶋茂雄
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] 培養細胞から放出されたE型肝炎ウイルスの粒子表面に存在する膜成分の抗原性の解析2012
- Author(s)
  長嶋茂雄
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪国際会議場(大阪市)
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] Tsg101 and vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011
- Author(s)
  Nagashima S
- Organizer
  14^<th> International Congress of Virology
- Place of Presentation
  札幌市
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus.2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H.
- Organizer
  15th International Congress of Virology (第59回日本ウイルス学会学術集会)
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H
- Organizer
  15thInternational Congress of Virology (第59回日本ウイルス学会学術集会)
- Place of Presentation
  札幌
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] Tsg101 and vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011
- Author(s)
  Nagashima, S., Takahashi, M., Jirintai, Tanaka, T., Nishizawa, T., Yasuda J, Okamoto, H
- Organizer
  XV International Congress of Virology
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] Genetic diversity of enterococci harboring high-level gentamicin resistance genes aac(6')-Ie-aph(2")-Ia or aph(2")-Ie in a Japanese hospital2010
- Author(s)
  小林宣道, 渡辺祥二郎, 長嶋茂雄, D.キニョネス, 漆原範子
- Organizer
  第14回国際感染症学会
- Place of Presentation
  米国・マイアミ
- Year and Date
  2010-03-12
- Data Source
  KAKENHI-PROJECT-20590608
[Presentation] Genetic diversity of enterococci harboring high-level gentamicin resistance genes aac(6')-Ie-aph(2")-Ia or aph(2")-Ie in a Japanese hospital.2010
- Author(s)
  Kobayashi N, Watanabe S, Nagashima S, Quinones D, Urushibara N
- Organizer
  14th International Congress on Infectious Diseases.
- Place of Presentation
  マイアミ、米国
- Year and Date
  2010-03-10
- Data Source
  KAKENHI-PROJECT-20590608
[Presentation] E型肝炎ウイルスのORF3蛋白質に認められるPSAPチーフのウイルス放出における機能解析2010
- Author(s)
  長嶋茂雄
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  徳島市
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] Molecular epidemiologic study of norovirus in sporadic cases of gastroenteritis in all age groups in Wuhan, China, 20082009
- Author(s)
  Wang Y-H, Kobayashi N, Peng J-S, Nagashima S, Zhou X, Yang T, Hu Q, Zhou D-J.
- Organizer
  8th Asia Pacific Congress of Medical Virology
- Place of Presentation
  香港
- Year and Date
  2009-02-26
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] Phylogenetic relatedness of G1, G3, and G9 rotaviruses between children and adults in Wuhan, China2009
- Author(s)
  Kobayashi N, Wang Y-H, Zhou X, Nagashima S, Peng J-S, Zhu Z-R, Liu M-Q, Hu Q, Zhou D-J.
- Organizer
  8th Asia Pacific Congress of Medical Virology
- Place of Presentation
  香港
- Year and Date
  2009-02-28
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] Phylogenetic analysis of G4P[6] rotavirus strain R479 isolated in Wuhan, China2009
- Author(s)
  Kobayashi N, Wang Y-H, Peng J-S, Nagashima S, Zhou X, Hu Q, Zhou D-J.
- Organizer
  8th Asia Pacific Congress of Medical Virology
- Place of Presentation
  香港
- Year and Date
  2009-02-26
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] 下利便におけるプロテオーム解析2009
- Author(s)
  石埜正穂、長嶋茂雄、三瀬敬治、小林宣道
- Organizer
  第79回日本衛生学会総会
- Place of Presentation
  東京
- Year and Date
  2009-03-31
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] Phylogenetic analysis of predominant G2, emerging G9 and G12 rotaviruses from children and adults in Bangladesh2008
- Author(s)
  Paul SK, Nagashima S, Kobayashi N, Ishino M, Watanabe S, Alam MM, Ahmed MU.
- Organizer
  The 42nd Joint Working Conference on Viral Diseases, The U.S.-Japan Cooperative Medical Science Program
- Place of Presentation
  長崎
- Year and Date
  2008-05-27
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] バングラデシュにおける小児および成人下痢症由来A群ロタウイルスの遺伝子学的解析.2008
- Author(s)
  長嶋茂雄
- Organizer
  日本ウイルス学会
- Place of Presentation
  岡山市
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] Whole sequence analysis of novel group rotavirus B219 and group B rotaviruses2008
- Author(s)
  Kobayashi N, Nagashima S, Alam M, Wang Y-H, Krishnan T, Chawla-Sarkar M.
- Organizer
  The 7th Japan-China International Conference of Virology
- Place of Presentation
  東京
- Year and Date
  2008-06-02
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] Molecular epidemiology of rotaviruses in Wuhan, China, Jun. 2006-Feb. 2008 : predominance of variant G3 strains and increase of G9 strains2008
- Author(s)
  Wang Y-H, Kobayashi N, Zhou X, Nagashima, S, Zhu Z-R, Sun S-H, Liu M-Q, Peng J-S, Hu Q, Zhou D-J.
- Organizer
  The 7th Japan-China International Conference of Virology
- Place of Presentation
  東京
- Year and Date
  2008-06-02
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] バングラデシュ(マイメンシン市)における小児および成人下痢症由来A群ロタウイルスの分子疫学的解析.2008
- Author(s)
  長嶋茂雄
- Organizer
  第78回日本衛生学会
- Place of Presentation
  熊本市民会館
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] "Host cellular proteins" : key determinants of rotavirus infection and pathogenesis2008
- Author(s)
  Chawla-Sarkar M, Dutta D, Bagchi P, Krishnan T, Nagashima S, Kobayashi N.
- Organizer
  Asian-African Research Forum on Emerging and Reemerging Infections
- Place of Presentation
  札幌
- Year and Date
  2008-12-16
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] 中国・武漢市における成人および小児下痢症由来G1, G3, G9 ロタウイルスの分子疫学的解析2008
- Author(s)
  小林宣道、長嶋茂雄、石埜正穂、渡辺祥二郎、Wang Yuanhong, Zhou Xuan
- Organizer
  第56回日本ウイルス学会
- Place of Presentation
  岡山
- Year and Date
  2008-10-27
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] バングラデシュ(マイメンシン市)における小児および成人下痢症由来A群ロタウイルスの分子疫学的解析2008
- Author(s)
  長嶋茂雄、渡辺祥二郎、石埜正穂、小林宣道
- Organizer
  第78回日本衛生学会
- Place of Presentation
  熊本
- Year and Date
  2008-03-29
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] バングラデシュにおける小児および成人下痢症由来A群ロタウイルスの遺伝子学的解析2008
- Author(s)
  長嶋茂雄、Paul Shyamal, 渡辺祥二郎、石埜正穂、小林宣道
- Organizer
  第56回日本ウイルス学会
- Place of Presentation
  岡山
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] 成人下痢症由来の新奇なヒトロタウイルスB219 株の分子疫学的解析2007
- Author(s)
  長嶋茂雄、石埜正穂、小林宣道
- Organizer
  第77回日本衛生学会
- Place of Presentation
  大阪
- Year and Date
  2007-03-28
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] 中国・武漢市における成人・小児下痢症由来A 群ロタウイルスの分子疫学的解析2007
- Author(s)
  小林宣道、石埜正穂、長嶋茂雄、三瀬敬治、鷲見紋子
- Organizer
  第77回日本衛生学会
- Place of Presentation
  大阪
- Year and Date
  2007-03-28
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] Whole genome characterization of a human rotavirus strain B219 that belongs to a novel rotavirus group2007
- Author(s)
  Nagashima S, Ishino M, Kobayashi N, Alam MM, Ahmed MU.
- Organizer
  The 41st Joint Working Conference on Viral Diseases, The U.S.-Japan Cooperative Medical Science Program
- Place of Presentation
  Baltimore, USA
- Year and Date
  2007-07-24
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] B群ヒトロタウイルスのVP1およびVP3遺伝子配列の解析2007
- Author(s)
  長嶋茂雄、石埜正穂、小林宣道
- Organizer
  第55回日本ウイルス学会
- Place of Presentation
  札幌
- Year and Date
  2007-10-22
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] Genetic characterization of Panton-Valentine leukocidine-producing Staphylococcus aureus in Bangladesh2006
- Author(s)
  Kobayashi, N., Afroz, S., Khan, MAH, Nagashima, S., Otokozawa, S., Wang, YH
- Organizer
  10th Western Pacific Congress on Chemotherapy and Infectious Diseases
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2006-12-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590521
[Presentation] 成人下痢症由来の新種ヒトロタウイルスB219 株の遺伝子解析2006
- Author(s)
  長嶋茂雄、石埜正穂、小林宣道
- Organizer
  第54回日本ウイルス学会
- Place of Presentation
  名古屋
- Year and Date
  2006-11-09
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] Diversity of staphylocoagulase genes and identification of a putative novel coagulase type in Staphylococcus aureus2006
- Author(s)
  Kobayashi, N., Kinoshita, M., Tsutsumi, H., Ishino, M., Nagashima, S., Mise, K., Uehara, N., Watanabe, N
- Organizer
  10th Western Pacific Congress on Chemotherapy and Infectious Diseases
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2006-12-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590521
[Presentation] 中国・武漢市における成人・小児下痢症由来A 群ロタウイルスの分子疫学的解析2006
- Author(s)
  小林宣道、石埜正穂、長嶋茂雄、三瀬敬治、鷲見紋子
- Organizer
  第54回日本ウイルス学会
- Place of Presentation
  名古屋
- Year and Date
  2006-11-20
- Data Source
  KAKENHI-PROJECT-18406018
[Presentation] E型肝炎ウイルスの細胞侵入機構の解析
- Author(s)
  長嶋茂雄、吉林台、小林富成、唐吉思、高橋雅春、西澤勉、岡本宏明
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25860343

1. ISHINO Masaho (30232325)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
2. KOBAYASHI Nobumichi (80186759)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
3. SUMI Ayako (10363699)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. OKAMOTO Hiroaki (30177092)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
5. TAKAHASHI Masaharu (70326841)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
6. KOBAYASHI Tominari (00634164)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
7. MISE Keiji (30200025)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
8. NISHIZAWA Tsutomu (30306112)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
9. TANIGUCHI Koki (40094213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. URUSHIBARA Noriko (80396308)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. YASUDA Jiro (10282518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. YASHIRO Takashi (80119859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. KOUKI Tom (70350436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 田中利典 (30146154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. T.N Naik

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. T Krishnan

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
17. M Chawla-sarkar

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
18. S.K Paul

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. M.M Alam

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. T.S Aung

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. Y-H Wang

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
22. X Zhou

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

Nagashima Shigeo 長嶋 茂雄

NAGASHIMA Mshigeo 長嶋 茂雄

NAGASHIMA Shigeo 長嶋 茂雄

Research Projects

Research Products

Co-Researchers

Identification of compounds that inhibit the early and late steps of hepatitis E virus infection and analysis of their inhibitory effects on the virus growthPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional evaluation of the candidate proteins of hepatitis E virus receptor and identification of host factors involved in the permissibility of infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and functional analysis of host factors involved in early steps of hepatitis E virus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on mechanism of hepatitis E virus egress utilizing membrane trafficPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particlesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEV

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on prevalence of PVL-positive Staphylococcus aureus and MRSA with the use of novel molecular epidemiologic methods

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of characteristics and prevalence of novel species rotavirus detected in Asia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

外来病原因子による下痢発症生理におけるプロテオーム解析

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and prevalence of antiseptip resistance genes in enterococci

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Chronic hepatitis E in an elderly immunocompetent patient who achieved a sustained virologic response with ribavirin treatment2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a HiBiT-tagged reporter hepatitis E virus and its utility as an antiviral drug screening platform2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development and Characterization of Efficient Cell Culture Systems for Genotype 1 Hepatitis E Virus and Its Infectious cDNA Clone2023

Author(s)

Journal Title

DOI

Nagashima Shigeo 長嶋茂雄

NAGASHIMA Mshigeo 長嶋茂雄

NAGASHIMA Shigeo 長嶋茂雄