Hashimoto Ryota 橋本良太

Researcher Number	60433786
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 順天堂大学, 医学部, 准教授 2021 – 2023: 順天堂大学, 医学部, 准教授 2018 – 2020: 順天堂大学, 医学部, 助教 2016: 順天堂大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Integrated Nutrition Science
Keywords	Principal Investigator 動脈硬化 / 酸化ＬＤＬ / マクロファージ / 泡沫化 / 酸化LDL / ビタミンB2 / シスチン / システイン Except Principal Investigator 再生血管 / 動脈硬化 … More / マクロファージ / 血管内皮細胞 / 慢性炎症 / iNOS / JAK-STAT経路 / MAPK / NO / 誘導型一酸化窒素合成酵素 / IL-12 / Toll様受容体 / JAK-STATシグナル / マイトジェン活性化プロテインキナーゼ / LPS / サイトカイン / サプリメント / 糖尿病 / コレステロール / 泡沫化 / 泡沫細胞 / スカベンジャー受容体 / 酸化LDL / システイン / シスチン / 虚血-再灌流障害 / 一酸化窒素合成酵素 / フコイダン / 血管弛緩反応 / 一酸化窒素 Less

TLRアゴニストの抗腫瘍作用をMEK阻害薬併用で促進させるPrincipal Investigator
- Principal Investigator
  
  橋本良太
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Juntendo University
炎症性マクロファージのiNOS制御による動脈硬化進展抑制および再生血管変性予防
- Principal Investigator
  
  加藤洋一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Juntendo University
Does excessive Vitamin B2 intake exacerbate the atherosclerosis?Principal Investigator
- Principal Investigator
  
  Ryota Hashimoto
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Juntendo University
Elucidation of the mechanism of atherosclerosis development by the nonessential fatty acid cysteine and its effect on regenerating blood vessels
- Principal Investigator
  
  Katoh Youichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Juntendo University
Does excessive cysteine intake exacerbate the atherosclerosis?Principal Investigator
- Principal Investigator
  
  Hashimoto Ryota
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Juntendo University
Investigation of the mechanism of nitric oxide production by an extract of brown marine algae and its usefulness as a functional food
- Principal Investigator
  
  Iesaki Takafumi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Integrated Nutrition Science
- Research Institution
  Juntendo University

All 2023 2022 2020 2019 2018

All Journal Article Presentation

[Journal Article] MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling.2023
- Author(s)
  Hashimoto-R, Koide-H, Katoh-Y
- Journal Title
  
  Cell Death Discov. 2023 Oct 13;9(1):374.
  
  Volume: 9 Issue: 1 Pages: 374-374
- DOI
  10.1038/s41420-023-01674-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K11711
[Journal Article] Long-term glucocorticoid treatment increases CD204 expression by activating the MAPK pathway and enhances modified LDL uptake in murine macrophages2023
- Author(s)
  Hashimoto-R, Koide-H, Katoh-Y
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 151 Issue: 1 Pages: 46-53
- DOI
  10.1016/j.jphs.2022.11.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11775, KAKENHI-PROJECT-20K19648, KAKENHI-PROJECT-22K11711
[Journal Article] G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation2022
- Author(s)
  Hashimoto Ryota、Gupte Sachin A.
- Journal Title
  
  Vascular Pharmacology
  
  Volume: 144 Pages: 106976-106976
- DOI
  10.1016/j.vph.2022.106976
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17977, KAKENHI-PROJECT-20K19648
[Journal Article] JAK-STAT-dependent regulation of scavenger receptors in LPS-activated murine macrophages2020
- Author(s)
  Hashimoto Ryota、Kakigi Ryo、Miyamoto Yuki、Nakamura Kyoko、Itoh Seigo、Daida Hiroyuki、Okada Takao、Katoh Youichi
- Journal Title
  
  European Journal of Pharmacology
  
  Volume: 871 Pages: 172940-172940
- DOI
  10.1016/j.ejphar.2020.172940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11775, KAKENHI-PROJECT-16K01836, KAKENHI-PROJECT-18K17977
[Journal Article] Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension2020
- Author(s)
  Hashimoto Ryota、Lanier Gregg M.、Dhagia Vidhi、Joshi Sachindra R.、Jordan Allan、Waddell Ian、Tuder Rubin、Stenmark Kurt R.、Wolin Michael S.、McMurtry Ivan F.、Gupte Sachin A.
- Journal Title
  
  American Journal of Physiology-Lung Cellular and Molecular Physiology
  
  Volume: 318 Issue: 2 Pages: L386-L401
- DOI
  10.1152/ajplung.00327.2019
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17977
[Journal Article] Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation2020
- Author(s)
  Joshi Sachindra Raj、Kitagawa Atsushi、Jacob Christina、Hashimoto Ryota、Dhagia Vidhi、Ramesh Amrit、Zheng Connie、Zhang Hui、Jordan Allan、Waddell Ian、Leopold Jane、Hu Cheng-Jun、McMurtry Ivan F.、D’Alessandro Angelo、Stenmark Kurt R.、Gupte Sachin A.
- Journal Title
  
  American Journal of Physiology-Lung Cellular and Molecular Physiology
  
  Volume: 318 Issue: 4 Pages: L773-L786
- DOI
  10.1152/ajplung.00001.2020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17977
[Journal Article] Phorbol 12-myristate 13-acetate (PMA) suppresses high Ca2+-enhanced adipogenesis in bone marrow stromal cells2019
- Author(s)
  Hashimoto Ryota、Miyamoto Yuki、Itoh Seigo、Daida Hiroyuki、Okada Takao、Katoh Youichi
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 69 Issue: 5 Pages: 741-748
- DOI
  10.1007/s12576-019-00690-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K11775, KAKENHI-PROJECT-16K01836
[Journal Article] A simple method to increase the proportion of bonemarrow-derived macrophages positive for M-CSFR using the reducing agent dithiothreitol (DTT)2018
- Author(s)
  Hashimoto-R, Daida-H, Okada-T, Katoh-Y
- Journal Title
  
  Methods X
  
  Volume: 5 Pages: 1540-1548
- DOI
  10.1016/j.mex.2018.11.014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01836, KAKENHI-PROJECT-18K17977
[Presentation] G6PD and CYP450 Enzyme Regulate Hematopoietic Stem Cell Biology: Implication to Pulmonary Artery Remodeling in Pulmonary Hypertension2018
- Author(s)
  Ryota Hashimoto, Sachindra Raj Joshi, Houli Jiang, Jorge H. Capdevila, Michal Laniado Schwartzman, Sachin A. Gupte
- Organizer
  American Heart Association’s Scientific Sessions 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K17977
[Presentation] Glucocorticoid decreases uptake of Ac-LDL through suppression of JAK-STAT pathway in macrophages2018
- Author(s)
  Ryota Hashimoto, Ryo Kakigi, Kyoko Nakamura, Yuki Miyamoto, Hiroyuki Daida, Takao Okada, Youichi Katoh
- Organizer
  第2回日本循環器学会基礎研究フォーラム
- Data Source
  KAKENHI-PROJECT-18K17977
[Presentation] Glucocorticoid decreases uptake of Ac-LDL through suppression of JAK-STATpathway in bone marrow-derived macrophages2018
- Author(s)
  Ryota Hashimoto, Yuki Miyamoto, Ryo Kakigi, Kyoko Nakamura, Hiroyuki Daida, Takao Okada, Youichi Katoh
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K17977

1. Katoh Youichi (00231259)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. Iesaki Takafumi (10348956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Kakigi Ryo (70614931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 渡邉マキノ (00255655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hashimoto Ryota 橋本 良太

Research Projects

Research Products

Co-Researchers

TLRアゴニストの抗腫瘍作用をMEK阻害薬併用で促進させるPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

炎症性マクロファージのiNOS制御による動脈硬化進展抑制および再生血管変性予防

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Does excessive Vitamin B2 intake exacerbate the atherosclerosis?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of atherosclerosis development by the nonessential fatty acid cysteine and its effect on regenerating blood vessels

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Does excessive cysteine intake exacerbate the atherosclerosis?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism of nitric oxide production by an extract of brown marine algae and its usefulness as a functional food

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term glucocorticoid treatment increases CD204 expression by activating the MAPK pathway and enhances modified LDL uptake in murine macrophages2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] JAK-STAT-dependent regulation of scavenger receptors in LPS-activated murine macrophages2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phorbol 12-myristate 13-acetate (PMA) suppresses high Ca2+-enhanced adipogenesis in bone marrow stromal cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A simple method to increase the proportion of bonemarrow-derived macrophages positive for M-CSFR using the reducing agent dithiothreitol (DTT)2018

Author(s)

Journal Title

DOI

Data Source

Hashimoto Ryota 橋本良太