Ohtake Fumiaki 大竹史明

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OHTAKE Fumiaki 大竹史明

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Researcher Number	60447373
Other IDs
Affiliation (Current)	2025: 星薬科大学, 先端生命科学研究所, 准教授 2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員
Affiliation (based on the past Project Information) *help	2024 – 2025: 星薬科大学, 先端生命科学研究所, 准教授 2019 – 2023: 星薬科大学, 先端生命科学研究所, 特任准教授 2016 – 2019: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 2011 – 2015: 国立医薬品食品衛生研究所, 毒性部, 主任研究官 2011: 東京大学, 分子細胞生物学研究所, 講師 2007 – 2010: The University of Tokyo, 分子細胞生物学研究所, 助教
Review Section/Research Field	Principal Investigator Functional biochemistry / Biological Sciences / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological Sciences / Basic Section 43030:Functional biochemistry-related / Transformative Research Areas, Section (III) / Biological pharmacy / Molecular biology Except Principal Investigator Complex systems / General medical chemistry / Biological Sciences
Keywords	Principal Investigator ユビキチン / 翻訳後修飾 / 蛋白質 / シグナル伝達 / タンパク質分解 / プロテアソーム / 環境 / 転写因子 / 発現制御 / プロテオミクス … More / PROTAC / タンパク質 / 質量分析 / ダイオキシン受容体 / がん / プロテオスタシス / タンパク質分解誘導剤 / アポトーシス / 標的タンパク質分解 / 遺伝子 / 脂溶性化合物 / 蛋白質分解 / 脂溶性リガンド / 環境応答 / 転写制御 / 転写共役因子 / 蛋白分解 … More Except Principal Investigator 質量分析計 / ケモテクノロジー / p97 / 液－液相分離 / 標的タンパク質分解誘導剤 / 質量分析 / プロテアソーム / ユビキチン / 細胞ネットワーク / 転写制御複合体 / 軟骨細胞特異的 / 核内受容体転写共役因子群 / ゲノムネットワーク / 破骨細胞 / 骨芽細胞 / 異変男性ホルモン受容体 / 転写共役因子 / 前立腺特異的AR欠損マウス / ホルモン非依存性癌 / ホルモン依存性癌 / 性ホルモン非依存性 / ホルモン受容体 / 染色体構造調節 / 核内受容体共役因子 / 変異男性ホルモン受容体 / ホルモン非依存性 / 性ホルモン受容体 / 核内因子複合体群 / 細胞周期依存的 / 転写制御 Less

分岐型ユビキチン鎖が担う細胞内機能の包括的解明Principal Investigator
- Principal Investigator
  
  大竹史明
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Hoshi University
Regulation of lifespan of proteins by the ubiquitin codePrincipal Investigator
- Principal Investigator
  
  大竹史明
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Hoshi University
Elucidating the role of branched ubiquitin codePrincipal Investigator
- Principal Investigator
  
  大竹史明
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Hoshi University
Identification of a new ubiquitin proteoformPrincipal Investigator
- Principal Investigator
  
  Ohtake Fumiaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Hoshi University
Decryption of the ubiquitin code by chemo-technologies and advanced proteomics
- Principal Investigator
  
  SAEKI Yasushi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Elucidating the role of branched ubiquitin codePrincipal Investigator
- Principal Investigator
  
  Ohtake Fumiaki
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hoshi University
  Tokyo Metropolitan Institute of Medical Science
Construction of quantitative reporter system for branched ubiquitin chainsPrincipal Investigator
- Principal Investigator
  
  OHTAKE Fumiaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Role of the ubiquitin system in the regulation of gene expressionPrincipal Investigator
- Principal Investigator
  
  OHTAKE Fumiaki
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
  National Institute of Health Sciences
蛋白質分解制御による新たなシグナル伝達機構の解明Principal Investigator
- Principal Investigator
  
  大竹史明
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Characterization of the ubiquitin codePrincipal Investigator
- Principal Investigator
  
  OHTAKE Fumiaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  National Institute of Health Sciences
  The University of Tokyo
Molecular pathways of fat-soluble ligands through the ubiquitin systemPrincipal Investigator
- Principal Investigator
  
  OHTAKE Fumiaki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Institute of Health Sciences
タンパク質分解を介した核内受容体機能と生物学的意義の解明Principal Investigator
- Principal Investigator
  
  大竹史明
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
脂溶性リガンドを受容するセルセンサーの新たな分子作用機序の解明Principal Investigator
- Principal Investigator
  
  大竹史明
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Regulation of post-translational modifications through fat-soluble ligandsPrincipal Investigator
- Principal Investigator
  
  OHTAKE Fumiaki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokyo
骨代謝制御因子としての核内ステロイド受容体群の機能
- Principal Investigator
  
  加藤茂明
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokyo
リガンド依存性ユビキチンリガーゼの機能制御機構の解明Principal Investigator
- Principal Investigator
  
  大竹史明
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
The role of the nuclear receptors in cancer development
- Principal Investigator
  
  KATO Shigeaki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] The AH Receptor in Biology and Toxicology' Chapter 10. The E3 ubiquitin ligase activity of transcription factor AHR permits nong enomic regulation of biological pathways2012
- Author(s)
  Ohtake F., Kato S.(Chapter 10)
- Publisher
  WILEY
- Data Source
  KAKENHI-PUBLICLY-23117512
[Book] 現代栄養学を理解するための分子生物学入門(5章シグナル伝達)(加藤茂明・編)2010
- Author(s)
  大竹史明
- Publisher
  光生館
- Data Source
  KAKENHI-PROJECT-21770134
[Book] ダイオキシン受容体はリガンド依存性E3ユビキチンリガーゼである2008
- Author(s)
  大竹史明、藤井義明、加藤茂明
- Total Pages
  233
- Publisher
  実験医学増刊タンパク質の分解機構
- Data Source
  KAKENHI-PROJECT-19044014
[Book] 転写制御とエピジェネティクス(第15章核内受容体によるクロマチン転写の分子機構)(加藤茂明・編)2008
- Author(s)
  加藤茂明、藤木亮次、大竹史明
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-21770134
[Journal Article] cIAP1-based degraders induce degradation via branched ubiquitin architectures2022
- Author(s)
  Akizuki Yoshino、Morita Mai、Mori Yuki、Kaiho-Soma Ai、Dixit Shivani、Endo Akinori、Shimogawa Marie、Hayashi Gosuke、Naito Mikihiko、Okamoto Akimitsu、Tanaka Keiji、Saeki Yasushi、Ohtake Fumiaki
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 19 Issue: 3 Pages: 311-322
- DOI
  10.1038/s41589-022-01178-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H00419, KAKENHI-PROJECT-20K06568, KAKENHI-PROJECT-21K19040, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-18H05504, KAKENHI-PROJECT-21H02777
[Journal Article] Branched ubiquitin code: from basic biology to targeted protein degradation2022
- Author(s)
  Ohtake Fumiaki
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 171 Issue: 4 Pages: 361-366
- DOI
  10.1093/jb/mvac002
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-20K21408
[Journal Article] Quality Control: Maintaining molecular order and preventing cellular chaos2022
- Author(s)
  Neal Sonya、Ohtake Fumiaki、Cuervo Ana Maria、Hegde Ramanujan S.、Jakob Ursula、Lazarou Michael、Gilbert Wendy V.、Chen Zhijian J.、Tooze Sharon A.、Haber James E.、Walters Kylie J.、Hartl F. Ulrich
- Journal Title
  
  Molecular Cell
  
  Volume: 82 Issue: 8 Pages: 1390-1397
- DOI
  10.1016/j.molcel.2022.04.002
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05498
[Journal Article] Frontier of the ubiquitin code research2021
- Author(s)
  佐伯泰、遠藤彬則、大竹史明
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 31 Issue: 3 Pages: 136-142
- DOI
  10.14894/medchem.31.3_136
- NAID
  130008070855
- ISSN
  2432-8618, 2432-8626
- Year and Date
  2021-08-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05498
[Journal Article] MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL2021
- Author(s)
  Nakabayashi Osamu、Takahashi Hirotaka、Moriwaki Kenta、Komazawa-Sakon Sachiko、Ohtake Fumiaki、Murai Shin、Tsuchiya Yuichi、Koyahara Yuki、Saeki Yasushi、Yoshida Yukiko、Yamazaki Soh、Tokunaga Fuminori、Sawasaki Tatsuya、Nakano Hiroyasu
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 80-80
- DOI
  10.1038/s42003-020-01603-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07399, KAKENHI-PROJECT-19K07516, KAKENHI-PROJECT-20K05238, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-20K11589, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-19H02926, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-20H03475, KAKENHI-PROJECT-20K09231, KAKENHI-PROJECT-19K22541, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-18H02619, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-16H06276
[Journal Article] TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains2021
- Author(s)
  Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 7 Pages: 1411-1424.e7
- DOI
  10.1016/j.molcel.2021.01.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-17H01882, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22726, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-21H03604, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-20K21408
[Journal Article] Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation2021
- Author(s)
  Huang Yifan、Yokoe Hiromasa、Kaiho-Soma Ai、Takahashi Kazunori、Hirasawa Yusuke、Morita Hiroshi、Ohtake Fumiaki、Kanoh Naoki
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 33 Issue: 1 Pages: 142-151
- DOI
  10.1021/acs.bioconjchem.1c00490
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-20K21408
[Journal Article] Branched ubiquitin chains and acetylated ubiquitin2020
- Author(s)
  大竹史明
- Journal Title
  
  生化学
  
  Volume: 92 Issue: 1 Pages: 57-63
- DOI
  10.14952/SEIKAGAKU.2020.920057
- ISSN
  0037-1017
- Year and Date
  2020-02-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05498
[Journal Article] A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets2020
- Author(s)
  Watanabe Masashi、Saeki Yasushi、Takahashi Hidehisa、Ohtake Fumiaki、Yoshida Yukiko、Kasuga Yusuke、Kondo Takeshi、Yaguchi Hiroaki、Suzuki Masanobu、Ishida Hiroki、Tanaka Keiji、Hatakeyama Shigetsugu
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 592-592
- DOI
  10.1038/s42003-020-01328-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22408, KAKENHI-PUBLICLY-19H05280, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18H02378, KAKENHI-PROJECT-18H02607, KAKENHI-PROJECT-19K22401, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497
[Journal Article] Mass Spectrometry Technologies for Deciphering the Ubiquitin Code2020
- Author(s)
  Ohtake Fumiaki
- Journal Title
  
  Trends in Biochemical Sciences
  
  Volume: 45 Issue: 9 Pages: 820-821
- DOI
  10.1016/j.tibs.2020.04.008
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05498
[Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome2020
- Author(s)
  Yasuda Sayaka、Tsuchiya Hikaru、Kaiho Ai、Guo Qiang、Ikeuchi Ken、Endo Akinori、Arai Naoko、Ohtake Fumiaki、Murata Shigeo、Inada Toshifumi、Baumeister Wolfgang、Fernandez-Busnadiego Ruben、Tanaka Keiji、Saeki Yasushi
- Journal Title
  
  Nature
  
  Volume: 578 Issue: 7794 Pages: 296-300
- DOI
  10.1038/s41586-020-1982-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05500, KAKENHI-PUBLICLY-19H05281, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-18K14913, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-19H00997
[Journal Article] 分岐型ユビキチン鎖とアセチル化ユビキチン2020
- Author(s)
  大竹史明
- Journal Title
  
  生化学
  
  Volume: 91 Pages: 57-63
- Data Source
  KAKENHI-PROJECT-17H03986
[Journal Article] The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC2020
- Author(s)
  Fuseya Yasuhiro、Fujita Hiroaki、Kim Minsoo、Ohtake Fumiaki、Nishide Akira、Sasaki Katsuhiro、Saeki Yasushi、Tanaka Keiji、Takahashi Ryosuke、Iwai Kazuhiro
- Journal Title
  
  Nature Cell Biology
  
  Volume: 22 Issue: 6 Pages: 663-673
- DOI
  10.1038/s41556-020-0517-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16144, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-19H00997, KAKENHI-PLANNED-18H05498, KAKENHI-PUBLICLY-20H05319, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-19K06635, KAKENHI-PUBLICLY-20H05505
[Journal Article] Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.2020
- Author(s)
  Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
- Journal Title
  
  Commun. Biol.
  
  Volume: 3 Issue: 1 Pages: 163-163
- DOI
  10.1038/s42003-020-0882-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22541, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-17K19560, KAKENHI-PROJECT-19K22968, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-19H04837, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06937, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-18H05497
[Journal Article] Methods to measure ubiquitin chain length and linkage.2019
- Author(s)
  Ohtake, F., Tsuchiya, H., Tanaka, K., and Saeki, Y.
- Journal Title
  
  Methods Enzymol
  
  Volume: 618 Pages: 105-133
- DOI
  10.1016/bs.mie.2018.12.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-16K14702
[Journal Article] K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.2018
- Author(s)
  Ohtake, F., Tsuchiya, H., Saeki, Y., and Tanaka, K
- Journal Title
  
  PNAS
  
  Volume: 115 Issue: 7 Pages: 1401-1408
- DOI
  10.1073/pnas.1716673115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
[Journal Article] Ub-ProT reveals global length and composition of protein ubiquitylation in cells2018
- Author(s)
  Tsuchiya, H., Burana, D., Ohtake, F., Arai, N., Kaiho, A., Komada, M., Tanaka,K., and Saeki, Y.
- Journal Title
  
  Nature Commun
  
  Volume: 9 Issue: 1 Pages: 524-524
- DOI
  10.1038/s41467-018-02869-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PUBLICLY-17H05681, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
[Journal Article] The complexity of ubiquitin architecture.2016
- Author(s)
  Ohtake, F., and Tsuchiya, H
- Journal Title
  
  J Biochem
  
  Volume: 161 Pages: 125-133
- DOI
  10.1093/jb/mvw088
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H06882, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-16K14702
[Journal Article] The K48-K63 branched ubiquitin chain regulates NF-kappaB signaling2016
- Author(s)
  Ohtake F, Saeki Y, Ishido S, Kanno J, Tanaka K
- Journal Title
  
  Mol. Cell
  
  Volume: 64 Issue: 2 Pages: 251-266
- DOI
  10.1016/j.molcel.2016.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24112003, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-16K14702
[Journal Article] Ubiquitin acetylation inhibits polyubiquitin chain elongation.2015
- Author(s)
  Ohtake F, Saeki Y, Sakamoto K, Ohtake K, Nishikawa H, Tsuchiya H, Ohta T, Tanaka K, Kanno J.
- Journal Title
  
  EMBO Rep.
  
  Volume: 16 Issue: 2 Pages: 192-201
- DOI
  10.15252/embr.201439152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24112005, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26290042, KAKENHI-PROJECT-26291035, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-26870853, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-26000014
[Journal Article] Epigenetic Silencing of Core Histone Genes by HERS in Drosophila.2012
- Author(s)
  Ito S, 他　（Ohtake F: 18人中13番目）
- Journal Title
  
  Molecular Cell
  
  Volume: 45 Pages: 494-504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657112
[Journal Article] JMJD5, a JmiC-domain-containing protein, negatively regulates osteoclastogenesis through facilitating NFATc1 protein degradation2012
- Author(s)
  Youn MY, Yokoyama A, Fujiyama-Nakamura S, Ohtake F, Minehata KI, Yasuda H, Suzuki T, Kato S, Imai Y
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 12994-3004
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117512
[Journal Article] JMJD5, a JmjC-domain-containing protein, negatively regulates osteoclastogenesis through facilitating NFATc1 protein degradation.2012
- Author(s)
  Youn MY, Yokoyama A, Fujiyama-Nakamura S, Ohtake F, Minehata KI, Yasuda H, Suzuki T, Kato S, *Imai Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 12994-3004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657112
[Journal Article] JMJD5, a jmjC-domain-containing protein, negatively regulates osteoclastogenesis through facillitating NFATc1 protein degradation2012
- Author(s)
  Youn MY, Yokoyama A, Fujiyama-Nakamura S, Ohtake F, Minehara KI, Yasuda H, Suzuki T, Kato S, Imai Y
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 12994-3004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23687016
[Journal Article] Epigenetic Silencing of Core Histone Genes by HERS in Drosophila2012
- Author(s)
  Ito S, Fujiyama-Nakamura S, Kimura S, Lim J, Kamoshida Y, Shiozaki-Sato Y, Sawatsubashi S, Suzuki E, Tanabe M, Ueda T, Murata T, Kato H, Ohtake F, Fujiki R, Miki T, Kouzmenko A, Takeyama K, Kato S
- Journal Title
  
  Molecular Cell
  
  Volume: 45 Pages: 494-504
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117512
[Journal Article] JMJD5, a JmjC-domain-containing protein, negatively regulates osteoclastogenesis through facilitating NFATc1 protein degradation2012
- Author(s)
  Youn MY, 他(Ohtake F., 著者9人)
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 12994-13004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23687016
[Journal Article] Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system.2011
- Author(s)
  Ohtake F, Fujii-Kuriyama Y, Kawajiri K, Kato S.
- Journal Title
  
  J Steroid Biochem Mol Biol. (published on line)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770134
[Journal Article] Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system.2011
- Author(s)
  Ohtake F, Fujii-Kuriyama Y, Kawajiri K, Kato S
- Journal Title
  
  J Steroid Biochem Mol Biol
  
  Volume: (Published on line)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21026005
[Journal Article] Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system.2011
- Author(s)
  Ohtake F, Fujii-Kuriyama Y, Kawajiri K, Kato S
- Journal Title
  
  J Steroid Biochem Mol Biol
  
  Volume: (Published on line)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21025007
[Journal Article] Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system.2011
- Author(s)
  Ohtake F, Fujii-Kuriyama Y, Kawajiri K, Kato S
- Journal Title
  
  J Steroid Biochem Mol Biol
  
  Volume: (Published on line)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770134
[Journal Article] PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B.2011
- Author(s)
  Baba A, Ohtake F, Okuno Y, Yokota K, Okada M, Imai Y, Ni M, Meyer CA, Igarashi K, Kanno J, Brown M, Kato S.
- Journal Title
  
  Nat Cell Biol. (published on line)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770134
[Journal Article] GlcNAcylation of histone H2B facilitates its monoubiquitination2011
- Author(s)
  Fujiki R, Hashiba W, Sekine H, Yokoyama A, Chikanishi T, Ito S, Imai Y, Kim J, He HH, Igarashi K, Kanno J, Ohtake F, Kitagawa H, Roeder RG, Brown M, Kato S
- Journal Title
  
  Nature
  
  Volume: 480 Pages: 557-560
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23117512
[Journal Article] Hormonal gene regulation through DNA methylation and demethylation2010
- Author(s)
  Kouzmenko, A, Ohtake, F, Fujiki, R, Kato S
- Journal Title
  
  EPIGENOMICS 2(6)
  
  Pages: 765-774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770134
[Journal Article] Hormonal gene regulation through DNA methylation and demethylation2010
- Author(s)
  Kouzmenko, A ; Ohtake, F ; Fujiki, R, Kato S
- Journal Title
  
  Epigenomics
  
  Volume: 2 Pages: 765-774
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21025007
[Journal Article] Hormonal gene regulation through DNA methylation and demethylation2010
- Author(s)
  Kouzmenko, A ; Ohtake, F ; Fujiki, R, Kato S
- Journal Title
  
  Epigenomics
  
  Volume: 2 Pages: 765-774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770134
[Journal Article] Hormonal gene regulation through DNA methylation and demethylation2010
- Author(s)
  Kouzmenko, A ; Ohtake, F ; Fujiki, R, Kato S
- Journal Title
  
  Epigenomics
  
  Volume: 2 Pages: 765-774
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21026005
[Journal Article] DNA demethylation in hormone-induced transcriptional derepression2009
- Author(s)
  Kim, M., Kondo, T., Takada, I., Youn, M., Yamamoto, Y., Takahashi, S., Matsumoto, T., Fujiyama, S., Shirode, Y., Yamaoka, I., Kitagawa H., Takeyama, K., Shibuya, H., Ohtake, F., Kato, S.
- Journal Title
  
  Nature 461
  
  Pages: 1007-1012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249014
[Journal Article] Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.2009
- Author(s)
  Kawajiri, K., Kobayashi, Y., Ohtake, F., Ikuta, T., Matsushima, Y., Mimura, J., Pettersson, S., Pollenz, R.S., Sakaki, T., Hirokawa, T., Akiyama, T., Kurosumi, M., Poellinger, L., Kato, S., Fujii-Kuriyama, Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 106
  
  Pages: 13481-13486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013023
[Journal Article] DNA demethylation in hormone-induced transcriptional derepression.2009
- Author(s)
  Yamamoto Y, Takahashi S, Matsumoto T, Fujiyama S, Shirode Y, Yamaoka I, Kitagawa H, Takeyama K, Shibuya H, Ohtake F, Kato S.
- Journal Title
  
  Nature. 461(7266)
  
  Pages: 1007-1012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770134
[Journal Article] AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions.2009
- Author(s)
  Ohtake F, Fujii-Kuriyama Y, Kato S.
- Journal Title
  
  Biochem Pharmacol. 77(4)
  
  Pages: 474-484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770134
[Journal Article] Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+mice with natural ligands.2009
- Author(s)
  Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, Pettersson S, Pollenz RS, Sakaki T, Hirokawa T, Akiyama T, Kurosumi M, Poellinger L, Kato S, Fujii-Kuriyama Y.
- Journal Title
  
  Proc Natl Acad Sci U S A. 106(32)
  
  Pages: 13481-13486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21770134
[Journal Article] DNA demethylation in hormone-induced transcriptional derepression.2009
- Author(s)
  Kim, M., Kondo, T., Takada, I., Youn, M., Yamamoto, Y., Takahashi, S., Matsumoto, T., Fujiyama, S., Shirode, Y., Yamaoka, I., Kitagawa, H., Takeyama, K., Shibuya, H., Ohtake, F., Kato, S.
- Journal Title
  
  Nature 461
  
  Pages: 1007-1012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013023
[Journal Article] AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions2008
- Author(s)
  Ohtake F, Fujii-Kuriyama Y, Kato S.
- Journal Title
  
  Biochem Pharmacol 77
  
  Pages: 474-478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19044014
[Journal Article] Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings2008
- Author(s)
  Ohtake F, Baba A, Fujii-Kuriyama Y, Kato S.
- Journal Title
  
  Biochem Biophys Res Commun 370
  
  Pages: 541-546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19044014
[Journal Article] Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings2008
- Author(s)
  Ohtake F, Baba A, Fujii-Kuriyama Y, and Kato S
- Journal Title
  
  Biochem Biophys Res Commun On line掲載
  
  Pages: 19-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19044014
[Journal Article] Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings. Biochem.2008
- Author(s)
  Ohtake, F., Baba, A., Fujii-Kuriyama, Y., Kato, S.
- Journal Title
  
  Biophys. Res. Commun. 370
  
  Pages: 541-546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013023
[Journal Article] A histone lysine methyltransferase activated by non-canonical Wnt signaling suppresses PPAR-γtransactivation.2007
- Author(s)
  Takada, I., Mihara, M., Suzawa, M., Ohtake, F., Igarashi, M., Takeyama, K., Nakamura, T., Mezaki, Y., Takezawa, S., Yogiashi, Y., Kitagawa, H., Yamada, G., Takada, S., Minami, Y., Shibuya, H., Matsumoto, K., Kato, S.
- Journal Title
  
  Nat. Cell Biol. 9
  
  Pages: 1273-1285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013023
[Journal Article] A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation2007
- Author(s)
  Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, Igarashi M, Youn MY, Takeyama K, Nakamura T, Mezaki Y, Takezawa S, Yogiashi Y, Kitagawa H, Yamada G, Takada S, Minami Y, Shibuya H, Matsumoto K, Kato S.
- Journal Title
  
  Nat Cell Biol 9
  
  Pages: 1273-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19044014
[Journal Article] Dioxin receptor is a ligand-dependent E3 ubiquitin ligase2007
- Author(s)
  Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A., Nohara, K., Chiba, T., Fujii-Kuriyama, Y., Kato, S.
- Journal Title
  
  Nature 446
  
  Pages: 562-566
- NAID
  40015761666
- Data Source
  KAKENHI-PROJECT-17013023
[Journal Article] Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.2007
- Author(s)
  Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A., Nohara, K., Chiba, T., Fujii-Kuriyama, Y., Kato, S.
- Journal Title
  
  Nature 446
  
  Pages: 562-566
- NAID
  40015761666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013023
[Presentation] 標的タンパク質分解誘導剤によるネオユビキチンコード形成機構2022
- Author(s)
  大竹史明
- Organizer
  第95回日本生化学会大会シンポジウム「ユビキチン・プロテアソーム研究のニューフロンティア」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] Role of the branched ubiquitin chains in targeted protein degradation2022
- Author(s)
  Fumiaki Ohtake
- Organizer
  Ubiquitin New Frontier "from Neo-Biology to Targeted Protein Degradation"
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] 分岐型ユビキチン鎖は標的タンパク質分解誘導剤の作用を促進する2022
- Author(s)
  大竹史明、秋月慶乃
- Organizer
  日本ケミカルバイオロジー学会第16回年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] 化合物による標的タンパク質分解を誘導するユビキチンコード2021
- Author(s)
  大竹史明
- Organizer
  第94回日本生化学大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] Branched ubiquitin chains promote chemically-induced targeted protein degradation2021
- Author(s)
  大竹史明、相馬愛、秋月慶乃
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21408
[Presentation] Branched ubiquitin chains promote chemically-induced targeted protein degradation2021
- Author(s)
  大竹史明、相馬愛、秋月慶乃
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] 化合物による標的タンパク質分解を誘導するユビキチンコード2021
- Author(s)
  大竹史明
- Organizer
  第94回日本生化学大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K21408
[Presentation] 標的タンパク質分解薬におけるユビキチン分岐鎖と役割2021
- Author(s)
  大竹史明
- Organizer
  第40回日本認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] Role of ubiquitin chain architecture revealed by chemo-technology2020
- Author(s)
  Ohtake Fumiaki
- Organizer
  第93回日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21408
[Presentation] Role of ubiquitin chain architecture revealed by chemo-technology2020
- Author(s)
  Fumiaki Ohtake
- Organizer
  第93回日本生化学会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] Role of ubiquitin chain architecture revealed by chemo-technology2020
- Author(s)
  Fumiaki Ohtake
- Organizer
  第93回日本生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] プロテオミクス解析から明らかになるユビキチン修飾のバイオロジー2020
- Author(s)
  大竹史明
- Organizer
  第68回質量分析総合討論会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21408
[Presentation] プロテオミクス解析から明らかになるユビキチン修飾のバイオロジー2020
- Author(s)
  大竹史明
- Organizer
  第68回質量分析総合討論会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] プロテオミクス解析から明らかになるユビキチン修飾のバイオロジー2020
- Author(s)
  大竹史明
- Organizer
  日本質量分析学会第68回質量分析総合討論会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] 分岐型ユビキチン鎖によるタンパク質分解制御機構2019
- Author(s)
  大竹史明
- Organizer
  第8回TOBIRA研究フォーラム
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] 質量分析技術とケミカルツールでユビキチン鎖の複雑性に挑む2019
- Author(s)
  大竹史明
- Organizer
  第4回先端ケミカルバイオロジー研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] 質量分析技術とケミカルツールでユビキチン鎖の複雑性に挑む2019
- Author(s)
  大竹史明
- Organizer
  第4回先端ケミカルバイオロジー研究会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] ケモテクノロジーと質量分析計を活用したユビキチンコードの解読2019
- Author(s)
  佐伯泰、遠藤彬則、土屋光、大竹史明
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] Proteomic analysis of K48/K63 branched ubiquitin chains.2019
- Author(s)
  Ohtake F, Naito M, Saeki Y, Tanaka K.
- Organizer
  EMBO Conference「The ubiquitin system: Biology, mechanism, and roles in disease」
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] ケモテクノロジーと質量分析計を活用したユビキチンコードの解読2019
- Author(s)
  佐伯泰、遠藤彬則、土屋光、大竹史明
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] Post-translational modification code of ubiquitin in signal transduction and protein degradation2018
- Author(s)
  Fumiaki Ohtake, Yasushi Saeki, and Keiji Tanaka
- Organizer
  第91回日本生化学会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] The ubiquitin ligases ITCH and UBR5 regulate proteasomal degradation through K48/K63 branched ubiquitin chains.2018
- Author(s)
  Ohtake, F., Saeki, Y., and Tanaka, K.
- Organizer
  第41回日本分子生物学会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] The NEDD4 family ubiquitin ligase ITCH regulates proteasomal degradation by seeding branched ubiquitin chains.2018
- Author(s)
  Fumiaki Ohtake, Yasushi Saeki, and Keiji Tanaka
- Organizer
  FASEB Conference ”Ubiquitin and cellular regulation”
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05498
[Presentation] The ubiquitin ligases ITCH and UBR5 regulate proteasomal degradation through K48/K63 branched ubiquitin chains2018
- Author(s)
  Ohtake F, Saeki Y, Tanaka K.
- Organizer
  第41回日本分子生物学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] Post-translational modification code of ubiquitin in signal transduction and protein degradation2018
- Author(s)
  Ohtake F, Saeki Y, Tanaka K.
- Organizer
  第91回日本生化学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K14702
[Presentation] Post-translational modification code of ubiquitin in signal transduction and protein degradation2018
- Author(s)
  Ohtake F, Saeki Y, Tanaka K.
- Organizer
  第91回日本生化学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] The ubiquitin ligases ITCH and UBR5 regulate proteasomal degradation through K48/K63 branched ubiquitin chains2018
- Author(s)
  Ohtake F, Saeki Y, Tanaka K.
- Organizer
  第41回日本分子生物学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K14702
[Presentation] The NEDD4 family ubiquitin ligase ITCH regulates proteasomal degradation by seeding branched ubiquitin chains.2018
- Author(s)
  5.Ohtake F, Saeki Y, Tanaka K
- Organizer
  FASEB Conference「Ubiquitin and cellular regulation」
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14702
[Presentation] The NEDD4 family ubiquitin ligase ITCH regulates proteasomal degradation by seeding branched ubiquitin chains.2018
- Author(s)
  Ohtake F, Saeki Y, Tanaka K.
- Organizer
  FASEB Conference「Ubiquitin and cellular regulation」
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] 出芽酵母におけるK48/K63分岐型ポリユビキチン鎖の解析2017
- Author(s)
  河野有紗、大竹史明、佐伯泰、田中啓二
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K14702
[Presentation] 炎症応答を制御する新たなユビキチン・シグナル2017
- Author(s)
  大竹史明、田中啓二
- Organizer
  第44回日本毒性学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K14702
[Presentation] Role of the K48/K63 branched ubiquitin chains in signal transduction and proteasomal degradation.2017
- Author(s)
  Ohtake F., Tanaka K.
- Organizer
  EMBO conference「Ubiquitin and SUMO」
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] 出芽酵母におけるK48/K63分岐型ポリユビキチン鎖の解析2017
- Author(s)
  河野有紗、大竹史明、佐伯泰、田中啓二
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] Role of the K48/K63 branched ubiquitin chains in signal transduction and proteasomal degradation2017
- Author(s)
  Ohtake F., Tanaka K
- Organizer
  EMBO conference「Ubiquitin and SUMO」
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14702
[Presentation] 炎症応答を制御する新たなユビキチン・シグナル2017
- Author(s)
  大竹史明、田中啓二
- Organizer
  第44回日本毒性学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03986
[Presentation] Quantitative analysis of the branched ubiquitin chains2016
- Author(s)
  Ohtake F, Saeki Y, Tanaka K
- Organizer
  第39回日本分子生物学会シンポジウム
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Invited
- Data Source
  KAKENHI-PLANNED-24112004
[Presentation] Cellular function of the Lys48/Lys63 branched ubiquitin chain.2016
- Author(s)
  Ohtake F
- Organizer
  国際シンポジウム「Diverse functions of Ubiquitin : Degradation, Signaling, and Beyond」
- Place of Presentation
  京都大学（京都府京都市）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K14702
[Presentation] Ubiquitin acetylation regulates polyubiquitin chain elongation2016
- Author(s)
  Ohtake F, Saeki Y, Tanaka K
- Organizer
  FASEB Conference‘Ubiquitin and cellular regulation’
- Place of Presentation
  Big Sky、米国
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24112004
[Presentation] Quantitative analysis of the branched ubiquitin chains2016
- Author(s)
  Ohtake F, Saeki Y, Tanaka K
- Organizer
  第39回日本分子生物学会シンポジウム
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Invited
- Data Source
  KAKENHI-PROJECT-16K14702
[Presentation] Cellular function of the Lys48/Lys63 branched ubiquitin chain2016
- Author(s)
  Ohtake F
- Organizer
  国際シンポジウム「Diverse functions of Ubiquitin : Degradation, Signaling, and Beyond」
- Place of Presentation
  京都大学（京都府京都市）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24112004
[Presentation] ERαはUBE3CのユビキチンE3リガーゼ活性に対するリガンド依存的な調整因子として機能する2015
- Author(s)
  1.岡田麻衣子、大竹史明、西川裕之、佐伯泰、田中啓二、太田智彦.
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PLANNED-24112004
[Presentation] ERはリガンド依存的なユビキチン化制御因子として機能する2015
- Author(s)
  3.岡田　麻衣子、西川　裕之、呉　文文、大竹　史明、佐伯　泰、田中啓二、太田　智彦
- Organizer
  日本内分泌学会第33回内分泌代謝学サマーセミナー
- Place of Presentation
  福岡県柳川市
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PLANNED-24112004
[Presentation] Ligand-regulated degradation of AhR involves a post-translational modificati on for ubiquitin2011
- Author(s)
  Ohtake F, Fujii-Kuriyama Y, Kato S
- Organizer
  日本生化学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23657112
[Presentation] Ubiquitin acetylation facilitates degradation of dioxin receptor2011
- Author(s)
  Ohtake F
- Organizer
  分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PUBLICLY-23117512
[Presentation] Ligand-selective poly-ubiquitin chain formation of AhR, a component of E3 complex2010
- Author(s)
  Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  リーガロイヤルホテル、大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PUBLICLY-21025007
[Presentation] Ligand-selective poly-ubiquitylation of AhR involves a transcriptional co-regulator CBP2010
- Author(s)
  大竹史明、加藤茂明
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21770134
[Presentation] Ligand-selective poly-ubiquitin chain formation of AhR, a component of E3 complex2010
- Author(s)
  Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  リーガロイヤルホテル、大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PUBLICLY-21026005
[Presentation] Ligand-selective poly-ubiquitin chain formation of AhR, a component of E3 complex2010
- Author(s)
  Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪シンポジウム
- Data Source
  KAKENHI-PROJECT-21770134
[Presentation] A transcription factor, AhR, acts as a ligand-dependent E3 ubiquitin ligase2010
- Author(s)
  Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
- Organizer
  Korea-Japan chromatin meeting
- Place of Presentation
  韓国国際シンポジウム
- Data Source
  KAKENHI-PROJECT-21770134
[Presentation] Ligand-selective poly-ubiquitin chain formation of AhR, a component of E3 complex2010
- Author(s)
  Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  リーガロイヤルホテル、大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-21770134
[Presentation] Association of AhR with ER exerts adverse estrogen-related effects2009
- Author(s)
  大竹史明、藤井義明、加藤茂明
- Organizer
  日本環境ホルモン学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21770134
[Presentation] Ah receptor acts as a ligand-dependent ubiquitin ligase2009
- Author(s)
  Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
- Organizer
  堀場・CDBIシンポジウム
- Place of Presentation
  東京国際シンポジウム
- Data Source
  KAKENHI-PROJECT-21770134
[Presentation] A signal-dependent histone lysine demethylase complex2009
- Author(s)
  大竹史明
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21770134
[Presentation] A signal-dependent histone lysine demethylase complex2009
- Author(s)
  大竹史明
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PUBLICLY-21025007
[Presentation] AhR acts as a ligand-dependent E3 ubiquitin ligase2009
- Author(s)
  大竹史明、藤井義明、加藤茂明
- Organizer
  日本生化学会
- Place of Presentation
  大阪シンポジウム
- Data Source
  KAKENHI-PROJECT-21770134
[Presentation] A signal-dependent histone lysine demethylase complex2009
- Author(s)
  大竹史明
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PUBLICLY-21026005
[Presentation] PHF2/ARID5B is a signal-dependent histone demethylase2009
- Author(s)
  大竹史明、藤井義明、加藤茂明
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜シンポジウム
- Data Source
  KAKENHI-PROJECT-21770134
[Presentation] リガンド依存性転写因子はユビキチンリガーゼ複合体として機能する2008
- Author(s)
  大竹史明、藤井義明、加藤茂明
- Organizer
  第31回日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19044014
[Presentation] ユビキチンリガーゼを介した脂溶性リガンド情報伝達機構の解明2007
- Author(s)
  大竹史明、藤井義明、加藤茂明
- Organizer
  分子生物学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19044014

1. KITAGAWA Hirochika (20345234)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. TAKEYAMA Ken-ichi (30323570)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. KATO Shigeaki (60204468)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. TAKADA Ichiro (50361655)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. SAEKI Yasushi (80462779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 山本陽子 (30376644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 安彦行人 (40370944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 土屋光 (90760132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. SYODA Takuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 渡部昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 村田茂穂

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 森脇健太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 太田智彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 田中啓二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 伏屋康寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 石戸聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 徳永文稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohtake Fumiaki 大竹 史明

OHTAKE Fumiaki 大竹 史明

Research Projects

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分岐型ユビキチン鎖が担う細胞内機能の包括的解明Principal Investigator

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Regulation of lifespan of proteins by the ubiquitin codePrincipal Investigator

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Elucidating the role of branched ubiquitin codePrincipal Investigator

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Identification of a new ubiquitin proteoformPrincipal Investigator

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Decryption of the ubiquitin code by chemo-technologies and advanced proteomics

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Elucidating the role of branched ubiquitin codePrincipal Investigator

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Construction of quantitative reporter system for branched ubiquitin chainsPrincipal Investigator

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Role of the ubiquitin system in the regulation of gene expressionPrincipal Investigator

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蛋白質分解制御による新たなシグナル伝達機構の解明Principal Investigator

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Characterization of the ubiquitin codePrincipal Investigator

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Molecular pathways of fat-soluble ligands through the ubiquitin systemPrincipal Investigator

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タンパク質分解を介した核内受容体機能と生物学的意義の解明Principal Investigator

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脂溶性リガンドを受容するセルセンサーの新たな分子作用機序の解明Principal Investigator

Principal Investigator

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Ohtake Fumiaki 大竹史明

OHTAKE Fumiaki 大竹史明

[Book] 現代栄養学を理解するための分子生物学入門(5章シグナル伝達)(加藤茂明・編)2010

[Book] 転写制御とエピジェネティクス(第15章核内受容体によるクロマチン転写の分子機構)(加藤茂明・編)2008