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Ohtake Fumiaki  大竹 史明

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OHTAKE Fumiaki  大竹 史明

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Researcher Number 60447373
Other IDs
Affiliation (Current) 2025: 星薬科大学, 先端生命科学研究所, 准教授
2025: 公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 研究員
Affiliation (based on the past Project Information) *help 2024 – 2025: 星薬科大学, 先端生命科学研究所, 准教授
2019 – 2023: 星薬科大学, 先端生命科学研究所, 特任准教授
2016 – 2019: 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員
2011 – 2015: 国立医薬品食品衛生研究所, 毒性部, 主任研究官
2011: 東京大学, 分子細胞生物学研究所, 講師
2007 – 2010: The University of Tokyo, 分子細胞生物学研究所, 助教
Review Section/Research Field
Principal Investigator
Functional biochemistry / Biological Sciences / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological Sciences / Basic Section 43030:Functional biochemistry-related / Transformative Research Areas, Section (III) / Biological pharmacy / Molecular biology
Except Principal Investigator
Complex systems / General medical chemistry / Biological Sciences
Keywords
Principal Investigator
ユビキチン / 翻訳後修飾 / 蛋白質 / シグナル伝達 / タンパク質分解 / プロテアソーム / 環境 / 転写因子 / 発現制御 / プロテオミクス … More / PROTAC / タンパク質 / 質量分析 / ダイオキシン受容体 / がん / プロテオスタシス / タンパク質分解誘導剤 / アポトーシス / 標的タンパク質分解 / 遺伝子 / 脂溶性化合物 / 蛋白質分解 / 脂溶性リガンド / 環境応答 / 転写制御 / 転写共役因子 / 蛋白分解 … More
Except Principal Investigator
質量分析計 / ケモテクノロジー / p97 / 液-液相分離 / 標的タンパク質分解誘導剤 / 質量分析 / プロテアソーム / ユビキチン / 細胞ネットワーク / 転写制御複合体 / 軟骨細胞特異的 / 核内受容体転写共役因子群 / ゲノムネットワーク / 破骨細胞 / 骨芽細胞 / 異変男性ホルモン受容体 / 転写共役因子 / 前立腺特異的AR欠損マウス / ホルモン非依存性癌 / ホルモン依存性癌 / 性ホルモン非依存性 / ホルモン受容体 / 染色体構造調節 / 核内受容体共役因子 / 変異男性ホルモン受容体 / ホルモン非依存性 / 性ホルモン受容体 / 核内因子複合体群 / 細胞周期依存的 / 転写制御 Less
  • Research Projects

    (17 results)
  • Research Products

    (113 results)
  • Co-Researchers

    (17 People)
  •  分岐型ユビキチン鎖が担う細胞内機能の包括的解明Principal Investigator

    • Principal Investigator
      大竹 史明
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Hoshi University
  •  Regulation of lifespan of proteins by the ubiquitin codePrincipal Investigator

    • Principal Investigator
      大竹 史明
    • Project Period (FY)
      2023 – 2027
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Hoshi University
  •  Elucidating the role of branched ubiquitin codePrincipal Investigator

    • Principal Investigator
      大竹 史明
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43030:Functional biochemistry-related
    • Research Institution
      Hoshi University
  •  Identification of a new ubiquitin proteoformPrincipal Investigator

    • Principal Investigator
      Ohtake Fumiaki
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Hoshi University
  •  Decryption of the ubiquitin code by chemo-technologies and advanced proteomics

    • Principal Investigator
      SAEKI Yasushi
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Elucidating the role of branched ubiquitin codePrincipal Investigator

    • Principal Investigator
      Ohtake Fumiaki
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hoshi University
      Tokyo Metropolitan Institute of Medical Science
  •  Construction of quantitative reporter system for branched ubiquitin chainsPrincipal Investigator

    • Principal Investigator
      OHTAKE Fumiaki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Functional biochemistry
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Role of the ubiquitin system in the regulation of gene expressionPrincipal Investigator

    • Principal Investigator
      OHTAKE Fumiaki
    • Project Period (FY)
      2012 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
      National Institute of Health Sciences
  •  蛋白質分解制御による新たなシグナル伝達機構の解明Principal Investigator

    • Principal Investigator
      大竹 史明
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Characterization of the ubiquitin codePrincipal Investigator

    • Principal Investigator
      OHTAKE Fumiaki
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Molecular biology
    • Research Institution
      National Institute of Health Sciences
      The University of Tokyo
  •  Molecular pathways of fat-soluble ligands through the ubiquitin systemPrincipal Investigator

    • Principal Investigator
      OHTAKE Fumiaki
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Functional biochemistry
    • Research Institution
      National Institute of Health Sciences
  •  タンパク質分解を介した核内受容体機能と生物学的意義の解明Principal Investigator

    • Principal Investigator
      大竹 史明
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  脂溶性リガンドを受容するセルセンサーの新たな分子作用機序の解明Principal Investigator

    • Principal Investigator
      大竹 史明
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Regulation of post-translational modifications through fat-soluble ligandsPrincipal Investigator

    • Principal Investigator
      OHTAKE Fumiaki
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokyo
  •  骨代謝制御因子としての核内ステロイド受容体群の機能

    • Principal Investigator
      加藤 茂明
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokyo
  •  リガンド依存性ユビキチンリガーゼの機能制御機構の解明Principal Investigator

    • Principal Investigator
      大竹 史明
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  The role of the nuclear receptors in cancer development

    • Principal Investigator
      KATO Shigeaki
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo

All 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book

  • [Book] The AH Receptor in Biology and Toxicology' Chapter 10. The E3 ubiquitin ligase activity of transcription factor AHR permits nong enomic regulation of biological pathways2012

    • Author(s)
      Ohtake F., Kato S.(Chapter 10)
    • Publisher
      WILEY
    • Data Source
      KAKENHI-PUBLICLY-23117512
  • [Book] 現代栄養学を理解するための分子生物学入門(5章 シグナル伝達)(加藤茂明・編)2010

    • Author(s)
      大竹史明
    • Publisher
      光生館
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Book] ダイオキシン受容体はリガンド依存性E3ユビキチンリガーゼである2008

    • Author(s)
      大竹史明、藤井義明、加藤茂明
    • Total Pages
      233
    • Publisher
      実験医学増刊 タンパク質の分解機構
    • Data Source
      KAKENHI-PROJECT-19044014
  • [Book] 転写制御とエピジェネティクス(第15章 核内受容体によるクロマチン転写の分子機構)(加藤茂明・編)2008

    • Author(s)
      加藤茂明、藤木亮次、大竹史明
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Journal Article] cIAP1-based degraders induce degradation via branched ubiquitin architectures2022

    • Author(s)
      Akizuki Yoshino、Morita Mai、Mori Yuki、Kaiho-Soma Ai、Dixit Shivani、Endo Akinori、Shimogawa Marie、Hayashi Gosuke、Naito Mikihiko、Okamoto Akimitsu、Tanaka Keiji、Saeki Yasushi、Ohtake Fumiaki
    • Journal Title

      Nature Chemical Biology

      Volume: 19 Issue: 3 Pages: 311-322

    • DOI

      10.1038/s41589-022-01178-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22H00419, KAKENHI-PROJECT-20K06568, KAKENHI-PROJECT-21K19040, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-18H05504, KAKENHI-PROJECT-21H02777
  • [Journal Article] Branched ubiquitin code: from basic biology to targeted protein degradation2022

    • Author(s)
      Ohtake Fumiaki
    • Journal Title

      The Journal of Biochemistry

      Volume: 171 Issue: 4 Pages: 361-366

    • DOI

      10.1093/jb/mvac002

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-20K21408
  • [Journal Article] Quality Control: Maintaining molecular order and preventing cellular chaos2022

    • Author(s)
      Neal Sonya、Ohtake Fumiaki、Cuervo Ana Maria、Hegde Ramanujan S.、Jakob Ursula、Lazarou Michael、Gilbert Wendy V.、Chen Zhijian J.、Tooze Sharon A.、Haber James E.、Walters Kylie J.、Hartl F. Ulrich
    • Journal Title

      Molecular Cell

      Volume: 82 Issue: 8 Pages: 1390-1397

    • DOI

      10.1016/j.molcel.2022.04.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Journal Article] Frontier of the ubiquitin code research2021

    • Author(s)
      佐伯 泰、遠藤 彬則、大竹 史明
    • Journal Title

      MEDCHEM NEWS

      Volume: 31 Issue: 3 Pages: 136-142

    • DOI

      10.14894/medchem.31.3_136

    • NAID

      130008070855

    • ISSN
      2432-8618, 2432-8626
    • Year and Date
      2021-08-01
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Journal Article] MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL2021

    • Author(s)
      Nakabayashi Osamu、Takahashi Hirotaka、Moriwaki Kenta、Komazawa-Sakon Sachiko、Ohtake Fumiaki、Murai Shin、Tsuchiya Yuichi、Koyahara Yuki、Saeki Yasushi、Yoshida Yukiko、Yamazaki Soh、Tokunaga Fuminori、Sawasaki Tatsuya、Nakano Hiroyasu
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1 Pages: 80-80

    • DOI

      10.1038/s42003-020-01603-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07399, KAKENHI-PROJECT-19K07516, KAKENHI-PROJECT-20K05238, KAKENHI-PROJECT-20K06611, KAKENHI-PROJECT-20K11589, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-19H02926, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-20H03475, KAKENHI-PROJECT-20K09231, KAKENHI-PROJECT-19K22541, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-18H02619, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-16H06276
  • [Journal Article] TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains2021

    • Author(s)
      Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
    • Journal Title

      Molecular Cell

      Volume: 81 Issue: 7 Pages: 1411-1424.e7

    • DOI

      10.1016/j.molcel.2021.01.023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-17H01882, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22726, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-21H03604, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-20K21408
  • [Journal Article] Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation2021

    • Author(s)
      Huang Yifan、Yokoe Hiromasa、Kaiho-Soma Ai、Takahashi Kazunori、Hirasawa Yusuke、Morita Hiroshi、Ohtake Fumiaki、Kanoh Naoki
    • Journal Title

      Bioconjugate Chemistry

      Volume: 33 Issue: 1 Pages: 142-151

    • DOI

      10.1021/acs.bioconjchem.1c00490

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-20K21408
  • [Journal Article] Branched ubiquitin chains and acetylated ubiquitin2020

    • Author(s)
      大竹 史明
    • Journal Title

      生化学

      Volume: 92 Issue: 1 Pages: 57-63

    • DOI

      10.14952/SEIKAGAKU.2020.920057

    • ISSN
      0037-1017
    • Year and Date
      2020-02-25
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Journal Article] A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets2020

    • Author(s)
      Watanabe Masashi、Saeki Yasushi、Takahashi Hidehisa、Ohtake Fumiaki、Yoshida Yukiko、Kasuga Yusuke、Kondo Takeshi、Yaguchi Hiroaki、Suzuki Masanobu、Ishida Hiroki、Tanaka Keiji、Hatakeyama Shigetsugu
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 592-592

    • DOI

      10.1038/s42003-020-01328-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22408, KAKENHI-PUBLICLY-19H05280, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18H02378, KAKENHI-PROJECT-18H02607, KAKENHI-PROJECT-19K22401, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497
  • [Journal Article] Mass Spectrometry Technologies for Deciphering the Ubiquitin Code2020

    • Author(s)
      Ohtake Fumiaki
    • Journal Title

      Trends in Biochemical Sciences

      Volume: 45 Issue: 9 Pages: 820-821

    • DOI

      10.1016/j.tibs.2020.04.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Journal Article] Stress- and ubiquitylation-dependent phase separation of the proteasome2020

    • Author(s)
      Yasuda Sayaka、Tsuchiya Hikaru、Kaiho Ai、Guo Qiang、Ikeuchi Ken、Endo Akinori、Arai Naoko、Ohtake Fumiaki、Murata Shigeo、Inada Toshifumi、Baumeister Wolfgang、Fernandez-Busnadiego Ruben、Tanaka Keiji、Saeki Yasushi
    • Journal Title

      Nature

      Volume: 578 Issue: 7794 Pages: 296-300

    • DOI

      10.1038/s41586-020-1982-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05500, KAKENHI-PUBLICLY-19H05281, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-18K14913, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-19H00997
  • [Journal Article] 分岐型ユビキチン鎖とアセチル化ユビキチン2020

    • Author(s)
      大竹史明
    • Journal Title

      生化学

      Volume: 91 Pages: 57-63

    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Journal Article] The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC2020

    • Author(s)
      Fuseya Yasuhiro、Fujita Hiroaki、Kim Minsoo、Ohtake Fumiaki、Nishide Akira、Sasaki Katsuhiro、Saeki Yasushi、Tanaka Keiji、Takahashi Ryosuke、Iwai Kazuhiro
    • Journal Title

      Nature Cell Biology

      Volume: 22 Issue: 6 Pages: 663-673

    • DOI

      10.1038/s41556-020-0517-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K16144, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-19H00997, KAKENHI-PLANNED-18H05498, KAKENHI-PUBLICLY-20H05319, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-19K06635, KAKENHI-PUBLICLY-20H05505
  • [Journal Article] Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.2020

    • Author(s)
      Oikawa D, Sato Y, Ohtake F, Komakura K, Hanada K, Sugawara K, Terawaki S, Mizukami Y, Phuong HT, Iio K, Obika S, Fukushi M, Irie T, Tsuruta D, Sakamoto S, Tanaka K, Saeki Y, Fukai S, Tokunaga F.
    • Journal Title

      Commun. Biol.

      Volume: 3 Issue: 1 Pages: 163-163

    • DOI

      10.1038/s42003-020-0882-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22541, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-17K19560, KAKENHI-PROJECT-19K22968, KAKENHI-PLANNED-16H06575, KAKENHI-PUBLICLY-19H04837, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06937, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-18H05497
  • [Journal Article] Methods to measure ubiquitin chain length and linkage.2019

    • Author(s)
      Ohtake, F., Tsuchiya, H., Tanaka, K., and Saeki, Y.
    • Journal Title

      Methods Enzymol

      Volume: 618 Pages: 105-133

    • DOI

      10.1016/bs.mie.2018.12.019

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K14913, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-16K14702
  • [Journal Article] K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.2018

    • Author(s)
      Ohtake, F., Tsuchiya, H., Saeki, Y., and Tanaka, K
    • Journal Title

      PNAS

      Volume: 115 Issue: 7 Pages: 1401-1408

    • DOI

      10.1073/pnas.1716673115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
  • [Journal Article] Ub-ProT reveals global length and composition of protein ubiquitylation in cells2018

    • Author(s)
      Tsuchiya, H., Burana, D., Ohtake, F., Arai, N., Kaiho, A., Komada, M., Tanaka,K., and Saeki, Y.
    • Journal Title

      Nature Commun

      Volume: 9 Issue: 1 Pages: 524-524

    • DOI

      10.1038/s41467-018-02869-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K14702, KAKENHI-PROJECT-26293018, KAKENHI-PUBLICLY-17H05681, KAKENHI-PROJECT-17H03986, KAKENHI-PROJECT-26000014
  • [Journal Article] The complexity of ubiquitin architecture.2016

    • Author(s)
      Ohtake, F., and Tsuchiya, H
    • Journal Title

      J Biochem

      Volume: 161 Pages: 125-133

    • DOI

      10.1093/jb/mvw088

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H06882, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-16K14702
  • [Journal Article] The K48-K63 branched ubiquitin chain regulates NF-kappaB signaling2016

    • Author(s)
      Ohtake F, Saeki Y, Ishido S, Kanno J, Tanaka K
    • Journal Title

      Mol. Cell

      Volume: 64 Issue: 2 Pages: 251-266

    • DOI

      10.1016/j.molcel.2016.09.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-24112003, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-16K14702
  • [Journal Article] Ubiquitin acetylation inhibits polyubiquitin chain elongation.2015

    • Author(s)
      Ohtake F, Saeki Y, Sakamoto K, Ohtake K, Nishikawa H, Tsuchiya H, Ohta T, Tanaka K, Kanno J.
    • Journal Title

      EMBO Rep.

      Volume: 16 Issue: 2 Pages: 192-201

    • DOI

      10.15252/embr.201439152

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-24112005, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-26290042, KAKENHI-PROJECT-26291035, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-26870853, KAKENHI-PLANNED-24112004, KAKENHI-PROJECT-26000014
  • [Journal Article] Epigenetic Silencing of Core Histone Genes by HERS in Drosophila.2012

    • Author(s)
      Ito S, 他 (Ohtake F: 18人中13番目)
    • Journal Title

      Molecular Cell

      Volume: 45 Pages: 494-504

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23657112
  • [Journal Article] JMJD5, a JmiC-domain-containing protein, negatively regulates osteoclastogenesis through facilitating NFATc1 protein degradation2012

    • Author(s)
      Youn MY, Yokoyama A, Fujiyama-Nakamura S, Ohtake F, Minehata KI, Yasuda H, Suzuki T, Kato S, Imai Y
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 12994-3004

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23117512
  • [Journal Article] JMJD5, a JmjC-domain-containing protein, negatively regulates osteoclastogenesis through facilitating NFATc1 protein degradation.2012

    • Author(s)
      Youn MY, Yokoyama A, Fujiyama-Nakamura S, Ohtake F, Minehata KI, Yasuda H, Suzuki T, Kato S, *Imai Y.
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 12994-3004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23657112
  • [Journal Article] JMJD5, a jmjC-domain-containing protein, negatively regulates osteoclastogenesis through facillitating NFATc1 protein degradation2012

    • Author(s)
      Youn MY, Yokoyama A, Fujiyama-Nakamura S, Ohtake F, Minehara KI, Yasuda H, Suzuki T, Kato S, Imai Y
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 12994-3004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23687016
  • [Journal Article] Epigenetic Silencing of Core Histone Genes by HERS in Drosophila2012

    • Author(s)
      Ito S, Fujiyama-Nakamura S, Kimura S, Lim J, Kamoshida Y, Shiozaki-Sato Y, Sawatsubashi S, Suzuki E, Tanabe M, Ueda T, Murata T, Kato H, Ohtake F, Fujiki R, Miki T, Kouzmenko A, Takeyama K, Kato S
    • Journal Title

      Molecular Cell

      Volume: 45 Pages: 494-504

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23117512
  • [Journal Article] JMJD5, a JmjC-domain-containing protein, negatively regulates osteoclastogenesis through facilitating NFATc1 protein degradation2012

    • Author(s)
      Youn MY, 他(Ohtake F., 著者9人)
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 12994-13004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23687016
  • [Journal Article] Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system.2011

    • Author(s)
      Ohtake F, Fujii-Kuriyama Y, Kawajiri K, Kato S.
    • Journal Title

      J Steroid Biochem Mol Biol. (published on line)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Journal Article] Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system.2011

    • Author(s)
      Ohtake F, Fujii-Kuriyama Y, Kawajiri K, Kato S
    • Journal Title

      J Steroid Biochem Mol Biol

      Volume: (Published on line)

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-21026005
  • [Journal Article] Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system.2011

    • Author(s)
      Ohtake F, Fujii-Kuriyama Y, Kawajiri K, Kato S
    • Journal Title

      J Steroid Biochem Mol Biol

      Volume: (Published on line)

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-21025007
  • [Journal Article] Cross-talk of dioxin and estrogen receptor signals through the ubiquitin system.2011

    • Author(s)
      Ohtake F, Fujii-Kuriyama Y, Kawajiri K, Kato S
    • Journal Title

      J Steroid Biochem Mol Biol

      Volume: (Published on line)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Journal Article] PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B.2011

    • Author(s)
      Baba A, Ohtake F, Okuno Y, Yokota K, Okada M, Imai Y, Ni M, Meyer CA, Igarashi K, Kanno J, Brown M, Kato S.
    • Journal Title

      Nat Cell Biol. (published on line)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Journal Article] GlcNAcylation of histone H2B facilitates its monoubiquitination2011

    • Author(s)
      Fujiki R, Hashiba W, Sekine H, Yokoyama A, Chikanishi T, Ito S, Imai Y, Kim J, He HH, Igarashi K, Kanno J, Ohtake F, Kitagawa H, Roeder RG, Brown M, Kato S
    • Journal Title

      Nature

      Volume: 480 Pages: 557-560

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23117512
  • [Journal Article] Hormonal gene regulation through DNA methylation and demethylation2010

    • Author(s)
      Kouzmenko, A, Ohtake, F, Fujiki, R, Kato S
    • Journal Title

      EPIGENOMICS 2(6)

      Pages: 765-774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Journal Article] Hormonal gene regulation through DNA methylation and demethylation2010

    • Author(s)
      Kouzmenko, A ; Ohtake, F ; Fujiki, R, Kato S
    • Journal Title

      Epigenomics

      Volume: 2 Pages: 765-774

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-21025007
  • [Journal Article] Hormonal gene regulation through DNA methylation and demethylation2010

    • Author(s)
      Kouzmenko, A ; Ohtake, F ; Fujiki, R, Kato S
    • Journal Title

      Epigenomics

      Volume: 2 Pages: 765-774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Journal Article] Hormonal gene regulation through DNA methylation and demethylation2010

    • Author(s)
      Kouzmenko, A ; Ohtake, F ; Fujiki, R, Kato S
    • Journal Title

      Epigenomics

      Volume: 2 Pages: 765-774

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-21026005
  • [Journal Article] DNA demethylation in hormone-induced transcriptional derepression2009

    • Author(s)
      Kim, M., Kondo, T., Takada, I., Youn, M., Yamamoto, Y., Takahashi, S., Matsumoto, T., Fujiyama, S., Shirode, Y., Yamaoka, I., Kitagawa H., Takeyama, K., Shibuya, H., Ohtake, F., Kato, S.
    • Journal Title

      Nature 461

      Pages: 1007-1012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249014
  • [Journal Article] Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands.2009

    • Author(s)
      Kawajiri, K., Kobayashi, Y., Ohtake, F., Ikuta, T., Matsushima, Y., Mimura, J., Pettersson, S., Pollenz, R.S., Sakaki, T., Hirokawa, T., Akiyama, T., Kurosumi, M., Poellinger, L., Kato, S., Fujii-Kuriyama, Y.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106

      Pages: 13481-13486

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013023
  • [Journal Article] DNA demethylation in hormone-induced transcriptional derepression.2009

    • Author(s)
      Yamamoto Y, Takahashi S, Matsumoto T, Fujiyama S, Shirode Y, Yamaoka I, Kitagawa H, Takeyama K, Shibuya H, Ohtake F, Kato S.
    • Journal Title

      Nature. 461(7266)

      Pages: 1007-1012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Journal Article] AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions.2009

    • Author(s)
      Ohtake F, Fujii-Kuriyama Y, Kato S.
    • Journal Title

      Biochem Pharmacol. 77(4)

      Pages: 474-484

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Journal Article] Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+mice with natural ligands.2009

    • Author(s)
      Kawajiri K, Kobayashi Y, Ohtake F, Ikuta T, Matsushima Y, Mimura J, Pettersson S, Pollenz RS, Sakaki T, Hirokawa T, Akiyama T, Kurosumi M, Poellinger L, Kato S, Fujii-Kuriyama Y.
    • Journal Title

      Proc Natl Acad Sci U S A. 106(32)

      Pages: 13481-13486

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Journal Article] DNA demethylation in hormone-induced transcriptional derepression.2009

    • Author(s)
      Kim, M., Kondo, T., Takada, I., Youn, M., Yamamoto, Y., Takahashi, S., Matsumoto, T., Fujiyama, S., Shirode, Y., Yamaoka, I., Kitagawa, H., Takeyama, K., Shibuya, H., Ohtake, F., Kato, S.
    • Journal Title

      Nature 461

      Pages: 1007-1012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013023
  • [Journal Article] AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions2008

    • Author(s)
      Ohtake F, Fujii-Kuriyama Y, Kato S.
    • Journal Title

      Biochem Pharmacol 77

      Pages: 474-478

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19044014
  • [Journal Article] Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings2008

    • Author(s)
      Ohtake F, Baba A, Fujii-Kuriyama Y, Kato S.
    • Journal Title

      Biochem Biophys Res Commun 370

      Pages: 541-546

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19044014
  • [Journal Article] Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings2008

    • Author(s)
      Ohtake F, Baba A, Fujii-Kuriyama Y, and Kato S
    • Journal Title

      Biochem Biophys Res Commun On line掲載

      Pages: 19-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19044014
  • [Journal Article] Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings. Biochem.2008

    • Author(s)
      Ohtake, F., Baba, A., Fujii-Kuriyama, Y., Kato, S.
    • Journal Title

      Biophys. Res. Commun. 370

      Pages: 541-546

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013023
  • [Journal Article] A histone lysine methyltransferase activated by non-canonical Wnt signaling suppresses PPAR-γtransactivation.2007

    • Author(s)
      Takada, I., Mihara, M., Suzawa, M., Ohtake, F., Igarashi, M., Takeyama, K., Nakamura, T., Mezaki, Y., Takezawa, S., Yogiashi, Y., Kitagawa, H., Yamada, G., Takada, S., Minami, Y., Shibuya, H., Matsumoto, K., Kato, S.
    • Journal Title

      Nat. Cell Biol. 9

      Pages: 1273-1285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013023
  • [Journal Article] A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation2007

    • Author(s)
      Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, Igarashi M, Youn MY, Takeyama K, Nakamura T, Mezaki Y, Takezawa S, Yogiashi Y, Kitagawa H, Yamada G, Takada S, Minami Y, Shibuya H, Matsumoto K, Kato S.
    • Journal Title

      Nat Cell Biol 9

      Pages: 1273-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19044014
  • [Journal Article] Dioxin receptor is a ligand-dependent E3 ubiquitin ligase2007

    • Author(s)
      Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A., Nohara, K., Chiba, T., Fujii-Kuriyama, Y., Kato, S.
    • Journal Title

      Nature 446

      Pages: 562-566

    • NAID

      40015761666

    • Data Source
      KAKENHI-PROJECT-17013023
  • [Journal Article] Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.2007

    • Author(s)
      Ohtake, F., Baba, A., Takada, I., Okada, M., Iwasaki, K., Miki, H., Takahashi, S., Kouzmenko, A., Nohara, K., Chiba, T., Fujii-Kuriyama, Y., Kato, S.
    • Journal Title

      Nature 446

      Pages: 562-566

    • NAID

      40015761666

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013023
  • [Presentation] 標的タンパク質分解誘導剤によるネオユビキチンコード形成機構2022

    • Author(s)
      大竹史明
    • Organizer
      第95回日本生化学会大会シンポジウム「ユビキチン・プロテアソーム研究のニューフロンティア」
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] Role of the branched ubiquitin chains in targeted protein degradation2022

    • Author(s)
      Fumiaki Ohtake
    • Organizer
      Ubiquitin New Frontier "from Neo-Biology to Targeted Protein Degradation"
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] 分岐型ユビキチン鎖は標的タンパク質分解誘導剤の作用を促進する2022

    • Author(s)
      大竹史明、秋月慶乃
    • Organizer
      日本ケミカルバイオロジー学会第16回年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] 化合物による標的タンパク質分解を誘導するユビキチンコード2021

    • Author(s)
      大竹史明
    • Organizer
      第94回日本生化学大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] Branched ubiquitin chains promote chemically-induced targeted protein degradation2021

    • Author(s)
      大竹史明、相馬愛、秋月慶乃
    • Organizer
      第44回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K21408
  • [Presentation] Branched ubiquitin chains promote chemically-induced targeted protein degradation2021

    • Author(s)
      大竹史明、相馬愛、秋月慶乃
    • Organizer
      第44回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] 化合物による標的タンパク質分解を誘導するユビキチンコード2021

    • Author(s)
      大竹史明
    • Organizer
      第94回日本生化学大会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K21408
  • [Presentation] 標的タンパク質分解薬におけるユビキチン分岐鎖と役割2021

    • Author(s)
      大竹史明
    • Organizer
      第40回日本認知症学会学術集会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] Role of ubiquitin chain architecture revealed by chemo-technology2020

    • Author(s)
      Ohtake Fumiaki
    • Organizer
      第93回日本生化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K21408
  • [Presentation] Role of ubiquitin chain architecture revealed by chemo-technology2020

    • Author(s)
      Fumiaki Ohtake
    • Organizer
      第93回日本生化学会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] Role of ubiquitin chain architecture revealed by chemo-technology2020

    • Author(s)
      Fumiaki Ohtake
    • Organizer
      第93回日本生化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] プロテオミクス解析から明らかになるユビキチン修飾のバイオロジー2020

    • Author(s)
      大竹史明
    • Organizer
      第68回質量分析総合討論会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K21408
  • [Presentation] プロテオミクス解析から明らかになるユビキチン修飾のバイオロジー2020

    • Author(s)
      大竹史明
    • Organizer
      第68回質量分析総合討論会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] プロテオミクス解析から明らかになるユビキチン修飾のバイオロジー2020

    • Author(s)
      大竹史明
    • Organizer
      日本質量分析学会第68回質量分析総合討論会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] 分岐型ユビキチン鎖によるタンパク質分解制御機構2019

    • Author(s)
      大竹史明
    • Organizer
      第8回TOBIRA研究フォーラム
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] 質量分析技術とケミカルツールでユビキチン鎖の複雑性に挑む2019

    • Author(s)
      大竹史明
    • Organizer
      第4回先端ケミカルバイオロジー研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] 質量分析技術とケミカルツールでユビキチン鎖の複雑性に挑む2019

    • Author(s)
      大竹史明
    • Organizer
      第4回先端ケミカルバイオロジー研究会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] ケモテクノロジーと質量分析計を活用したユビキチンコードの解読2019

    • Author(s)
      佐伯 泰、遠藤彬則、土屋 光、大竹史明
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] Proteomic analysis of K48/K63 branched ubiquitin chains.2019

    • Author(s)
      Ohtake F, Naito M, Saeki Y, Tanaka K.
    • Organizer
      EMBO Conference「The ubiquitin system: Biology, mechanism, and roles in disease」
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] ケモテクノロジーと質量分析計を活用したユビキチンコードの解読2019

    • Author(s)
      佐伯 泰、遠藤彬則、土屋 光、大竹史明
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] Post-translational modification code of ubiquitin in signal transduction and protein degradation2018

    • Author(s)
      Fumiaki Ohtake, Yasushi Saeki, and Keiji Tanaka
    • Organizer
      第91回日本生化学会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] The ubiquitin ligases ITCH and UBR5 regulate proteasomal degradation through K48/K63 branched ubiquitin chains.2018

    • Author(s)
      Ohtake, F., Saeki, Y., and Tanaka, K.
    • Organizer
      第41回日本分子生物学会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] The NEDD4 family ubiquitin ligase ITCH regulates proteasomal degradation by seeding branched ubiquitin chains.2018

    • Author(s)
      Fumiaki Ohtake, Yasushi Saeki, and Keiji Tanaka
    • Organizer
      FASEB Conference ”Ubiquitin and cellular regulation”
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05498
  • [Presentation] The ubiquitin ligases ITCH and UBR5 regulate proteasomal degradation through K48/K63 branched ubiquitin chains2018

    • Author(s)
      Ohtake F, Saeki Y, Tanaka K.
    • Organizer
      第41回日本分子生物学会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] Post-translational modification code of ubiquitin in signal transduction and protein degradation2018

    • Author(s)
      Ohtake F, Saeki Y, Tanaka K.
    • Organizer
      第91回日本生化学会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K14702
  • [Presentation] Post-translational modification code of ubiquitin in signal transduction and protein degradation2018

    • Author(s)
      Ohtake F, Saeki Y, Tanaka K.
    • Organizer
      第91回日本生化学会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] The ubiquitin ligases ITCH and UBR5 regulate proteasomal degradation through K48/K63 branched ubiquitin chains2018

    • Author(s)
      Ohtake F, Saeki Y, Tanaka K.
    • Organizer
      第41回日本分子生物学会シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K14702
  • [Presentation] The NEDD4 family ubiquitin ligase ITCH regulates proteasomal degradation by seeding branched ubiquitin chains.2018

    • Author(s)
      5.Ohtake F, Saeki Y, Tanaka K
    • Organizer
      FASEB Conference「Ubiquitin and cellular regulation」
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K14702
  • [Presentation] The NEDD4 family ubiquitin ligase ITCH regulates proteasomal degradation by seeding branched ubiquitin chains.2018

    • Author(s)
      Ohtake F, Saeki Y, Tanaka K.
    • Organizer
      FASEB Conference「Ubiquitin and cellular regulation」
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] 出芽酵母におけるK48/K63分岐型ポリユビキチン鎖の解析2017

    • Author(s)
      河野有紗、大竹史明、佐伯泰、田中啓二
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-16K14702
  • [Presentation] 炎症応答を制御する新たなユビキチン・シグナル2017

    • Author(s)
      大竹史明、田中啓二
    • Organizer
      第44回日本毒性学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K14702
  • [Presentation] Role of the K48/K63 branched ubiquitin chains in signal transduction and proteasomal degradation.2017

    • Author(s)
      Ohtake F., Tanaka K.
    • Organizer
      EMBO conference「Ubiquitin and SUMO」
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] 出芽酵母におけるK48/K63分岐型ポリユビキチン鎖の解析2017

    • Author(s)
      河野有紗、大竹史明、佐伯泰、田中啓二
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] Role of the K48/K63 branched ubiquitin chains in signal transduction and proteasomal degradation2017

    • Author(s)
      Ohtake F., Tanaka K
    • Organizer
      EMBO conference「Ubiquitin and SUMO」
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K14702
  • [Presentation] 炎症応答を制御する新たなユビキチン・シグナル2017

    • Author(s)
      大竹史明、田中啓二
    • Organizer
      第44回日本毒性学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03986
  • [Presentation] Quantitative analysis of the branched ubiquitin chains2016

    • Author(s)
      Ohtake F, Saeki Y, Tanaka K
    • Organizer
      第39回日本分子生物学会シンポジウム
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Invited
    • Data Source
      KAKENHI-PLANNED-24112004
  • [Presentation] Cellular function of the Lys48/Lys63 branched ubiquitin chain.2016

    • Author(s)
      Ohtake F
    • Organizer
      国際シンポジウム「Diverse functions of Ubiquitin : Degradation, Signaling, and Beyond」
    • Place of Presentation
      京都大学(京都府京都市)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K14702
  • [Presentation] Ubiquitin acetylation regulates polyubiquitin chain elongation2016

    • Author(s)
      Ohtake F, Saeki Y, Tanaka K
    • Organizer
      FASEB Conference‘Ubiquitin and cellular regulation’
    • Place of Presentation
      Big Sky、米国
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-24112004
  • [Presentation] Quantitative analysis of the branched ubiquitin chains2016

    • Author(s)
      Ohtake F, Saeki Y, Tanaka K
    • Organizer
      第39回日本分子生物学会シンポジウム
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K14702
  • [Presentation] Cellular function of the Lys48/Lys63 branched ubiquitin chain2016

    • Author(s)
      Ohtake F
    • Organizer
      国際シンポジウム「Diverse functions of Ubiquitin : Degradation, Signaling, and Beyond」
    • Place of Presentation
      京都大学(京都府京都市)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-24112004
  • [Presentation] ERαはUBE3CのユビキチンE3リガーゼ活性に対するリガンド依存的な調整因子として機能する2015

    • Author(s)
      1.岡田麻衣子、大竹史明、西川裕之、佐伯泰、田中啓二、太田智彦.
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PLANNED-24112004
  • [Presentation] ERはリガンド依存的なユビキチン化制御因子として機能する2015

    • Author(s)
      3.岡田 麻衣子、西川 裕之、呉 文文、大竹 史明、佐伯 泰、田中啓二、太田 智彦
    • Organizer
      日本内分泌学会 第33回内分泌代謝学サマーセミナー
    • Place of Presentation
      福岡県柳川市
    • Year and Date
      2015-07-09
    • Data Source
      KAKENHI-PLANNED-24112004
  • [Presentation] Ligand-regulated degradation of AhR involves a post-translational modificati on for ubiquitin2011

    • Author(s)
      Ohtake F, Fujii-Kuriyama Y, Kato S
    • Organizer
      日本生化学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-23657112
  • [Presentation] Ubiquitin acetylation facilitates degradation of dioxin receptor2011

    • Author(s)
      Ohtake F
    • Organizer
      分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Data Source
      KAKENHI-PUBLICLY-23117512
  • [Presentation] Ligand-selective poly-ubiquitin chain formation of AhR, a component of E3 complex2010

    • Author(s)
      Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      リーガロイヤルホテル、大阪
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PUBLICLY-21025007
  • [Presentation] Ligand-selective poly-ubiquitylation of AhR involves a transcriptional co-regulator CBP2010

    • Author(s)
      大竹史明、加藤茂明
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Presentation] Ligand-selective poly-ubiquitin chain formation of AhR, a component of E3 complex2010

    • Author(s)
      Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      リーガロイヤルホテル、大阪
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PUBLICLY-21026005
  • [Presentation] Ligand-selective poly-ubiquitin chain formation of AhR, a component of E3 complex2010

    • Author(s)
      Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪 シンポジウム
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Presentation] A transcription factor, AhR, acts as a ligand-dependent E3 ubiquitin ligase2010

    • Author(s)
      Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
    • Organizer
      Korea-Japan chromatin meeting
    • Place of Presentation
      韓国 国際シンポジウム
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Presentation] Ligand-selective poly-ubiquitin chain formation of AhR, a component of E3 complex2010

    • Author(s)
      Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      リーガロイヤルホテル、大阪
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Presentation] Association of AhR with ER exerts adverse estrogen-related effects2009

    • Author(s)
      大竹史明、藤井義明、加藤茂明
    • Organizer
      日本環境ホルモン学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Presentation] Ah receptor acts as a ligand-dependent ubiquitin ligase2009

    • Author(s)
      Fumiaki Ohtake, Yoshiaki Fujii-Kuriyama, Shigeaki Kato
    • Organizer
      堀場・CDBIシンポジウム
    • Place of Presentation
      東京 国際シンポジウム
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Presentation] A signal-dependent histone lysine demethylase complex2009

    • Author(s)
      大竹史明
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Presentation] A signal-dependent histone lysine demethylase complex2009

    • Author(s)
      大竹史明
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PUBLICLY-21025007
  • [Presentation] AhR acts as a ligand-dependent E3 ubiquitin ligase2009

    • Author(s)
      大竹史明、藤井義明、加藤茂明
    • Organizer
      日本生化学会
    • Place of Presentation
      大阪 シンポジウム
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Presentation] A signal-dependent histone lysine demethylase complex2009

    • Author(s)
      大竹史明
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-09
    • Data Source
      KAKENHI-PUBLICLY-21026005
  • [Presentation] PHF2/ARID5B is a signal-dependent histone demethylase2009

    • Author(s)
      大竹史明、藤井義明、加藤茂明
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜 シンポジウム
    • Data Source
      KAKENHI-PROJECT-21770134
  • [Presentation] リガンド依存性転写因子はユビキチンリガーゼ複合体として機能する2008

    • Author(s)
      大竹史明、藤井義明、加藤茂明
    • Organizer
      第31回日本分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Data Source
      KAKENHI-PROJECT-19044014
  • [Presentation] ユビキチンリガーゼを介した脂溶性リガンド情報伝達機構の解明2007

    • Author(s)
      大竹史明、藤井義明、加藤茂明
    • Organizer
      分子生物学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19044014
  • 1.  KITAGAWA Hirochika (20345234)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 3 results
  • 2.  TAKEYAMA Ken-ichi (30323570)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 3.  KATO Shigeaki (60204468)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 4.  TAKADA Ichiro (50361655)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 5.  SAEKI Yasushi (80462779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 6.  山本 陽子 (30376644)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  安彦 行人 (40370944)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  土屋 光 (90760132)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 9.  SYODA Takuji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  渡部 昌
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  村田 茂穂
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  森脇 健太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  太田 智彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  田中 啓二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  伏屋 康寛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  石戸 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  徳永 文稔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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