Isobe Noriko 磯部紀子

Researcher Number	60452752
Other IDs
Affiliation (Current)	2025: 九州大学, 医学研究院, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 九州大学, 医学研究院, 教授 2021: 九州大学, 医学研究院, 准教授 2020: 九州大学, 医学研究院, 特任准教授 2017 – 2019: 九州大学, 医学研究院, 准教授
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Basic Section 52020:Neurology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 8:Sociology and related fields / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator 多発性硬化症 / 遺伝子解析 / mRNA品質管理機構 / 重症化因子 / 視神経脊髄炎スペクトラム障害 / 中枢神経系自己免疫性疾患 / 性染色体 / 一塩基多型 / HLA / 疾患感受性遺伝子 … More / SNP / 遺伝的刷り込み / エピジェネティクス / 関連解析 / 遺伝的凝集度 / 片親起源効果 / 疾患多様性 / 遺伝的要因 / パスウェイ解析 / 遺伝子型表現型関連解析 … More Except Principal Investigator 多発性硬化症 / 自己抗体 / 環境因子 / 視神経脊髄炎 / 視神経脊髄炎スペクトラム障害 / バイオマーカー / 神経障害性疼痛 / ノド抗体 / 慢性炎症性脱髄性多発神経炎 / 脱髄疾患 / 神経免疫疾患 / 免疫細胞 / 疾患修飾薬 / B細胞 / CD20陽性T細胞 / 抗CD20抗体 / 免疫治療 / ランビエ絞輪 / peripheral nerve / node of Ranvier / autoantibody / demyelinaiton / multiple sclerosis / 治療選択 / 予後不良因子 / 遺伝的要因 / 医療体制 / 多様な働き方 / 職場環境 / 医療職 / 海外研究 / キャリアの継続 / 医療環境の国際比較 / 働き方改革 / 持続可能な医療体制 / 高度専門職 / 精神的健康度 / 労働衛生的視点 / キャリア継続 / 女性医療人 / 脊髄障害 / BKチャネル / KCNMA1 / アストロサイト / 遺伝環境リスク / 抗核抗体 / PlexinD1 / NF155 / 慢性炎症性脱髄性多発神経根炎 / 神経内科疾患 / アトピー性脊髄炎 / アトピー / 遺伝子 / 自己免疫 / 進行性多層背白質脳症 / HLA / JCウイルス / 進行性多巣性白質脳症 / 腸内細菌叢 / 米 / 食事 / 免疫細胞解析 / 喫煙 / コメ摂取 Less

Elucidation of inflammation regulatory mechanisms in central nervous system autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  磯部紀子
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
免疫学的視点からみた中枢性神経障害性疼痛の病態解明ならびに新規治療法開発
- Principal Investigator
  
  藤井敬之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
CD20陽性T細胞とB細胞に注目した多発性硬化症病態の解明
- Principal Investigator
  
  篠田紘司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
中枢神経炎症性疾患の治療を遺伝・免疫・血清学的指標を用いて最適化する方法の確立
- Principal Investigator
  
  渡邉充
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyushu University
Elucidation of mechanisms of central and peripheral nervous system demyelination caused by newly discovered anti-nodal antibodies in autoimmune nodopathy
- Principal Investigator
  
  吉良潤一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  International University of Health and Welfare
Identification of interaction between sex chromosomes and HLA in central nervous system autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  Isobe Noriko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Development of an international survey and research on diverse work styles of healthcare professionals toward a sustainable healthcare system
- Principal Investigator
  
  Chishaki Akiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 8:Sociology and related fields
- Research Institution
  Fukuoka Nursing College
Novel therapy for spinal cord damage of neuromyelitis optica via regulation of BK channel
- Principal Investigator
  
  Matsushita Takuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Development of treatment for multiple sclerosis based on rice consumption, a newly identified environmental risk factor
- Principal Investigator
  
  Watanabe Mitsuru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Elucidation and Prevention of Progressive Multifocal Leukoencephalopathy Induced by Disease-Modifying Drugs in Japanese Patients with Multiple Sclerosis
- Principal Investigator
  
  Kawano Yuji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
Elucidation of autoimmune mechanisms and developement of novel therapy for demyelinating diseases based on genetic and envrionmental risk factors and disease-specific anti-neural antibodies
- Principal Investigator
  
  Kira Jun-ichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  International University of Health and Welfare
  Kyushu University
Parent-of-origin effect in multiple sclerosis susceptibilityPrincipal Investigator
- Principal Investigator
  
  Isobe Noriko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyushu University
パスウェイバーデン解析に基づく多発性硬化症リスク遺伝子の疾患多様性への寄与の解明Principal Investigator
- Principal Investigator
  
  磯部紀子
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Kyushu University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] 多発性硬化症のコホート研究2024
- Author(s)
  磯部　紀子
- Journal Title
  
  脳神経内科
  
  Volume: 100 Pages: 26-28
- Data Source
  KAKENHI-PROJECT-21K07464
[Journal Article] Effect of smoking on disease activity in multiple sclerosis patients treated with dimethyl fumarate or fingolimod2023
- Author(s)
  Tanaka E, Watanabe M, Fukumoto S, Masaki K, Yamasaki R, Matsushita T, Isobe N
- Journal Title
  
  Mult Scler Relat Disord
  
  Volume: - Pages: 104513-104513
- DOI
  10.1016/j.msard.2023.104513
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07464, KAKENHI-PROJECT-22K07351, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-23K06965
[Journal Article] Granulocyte activation markers in cerebrospinal fluid differentiate acute neuromyelitis spectrum disorder from multiple sclerosis.2023
- Author(s)
  Leppert D, Watanabe M, Schaedelin S, Piehl F, Furlan R, Gastaldi M, Lambert J, Evertsson B, Fink K, Matsushita T, Masaki K, Isobe N, Kira JI, Benkert P, Maceski A, Willemse E, Oechtering J, Orleth A, Meier S, Kuhle J.
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07464
[Journal Article] A case report of anti-N-methyl-d-aspartate receptor encephalitis with chromosomally integrated human herpesvirus 6.2023
- Author(s)
  Iwao K, Watanabe M, Mukaino T, Fujii T, Yamasaki R, Isobe N.
- Journal Title
  
  Neurol Clin Neurosci.
  
  Volume: 11 Issue: 1 Pages: 52-54
- DOI
  10.1111/ncn3.12681
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07464
[Journal Article] Polygenic risk score association with multiple sclerosis susceptibility and phenotype in Europeans2022
- Author(s)
  Shams Hengameh、Shao Xiaorong、Santaniello Adam、Kirkish Gina、Harroud Adil、Ma Qin、Isobe Noriko、Schaefer Catherine、McCauley Jacob L.、Cree Bruce A. C.、Didonna Alessandro、Baranzini Sergio E.、Patsopoulos Nikolaos A.、Hauser Stephen L.、Barcellos Lisa F.、Henry Roland G.、Oksenberg Jorge R.、et al.
- Journal Title
  
  Brain
  
  Volume: - Issue: 2 Pages: 645-656
- DOI
  10.1093/brain/awac092
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07464
[Journal Article] Choroid Plexus Volume in Multiple Sclerosis vs Neuromyelitis Optica Spectrum Disorder: A Retrospective, Cross-sectional Analysis2022
- Author(s)
  Fukumoto S, Watanabe M, Masaki K, Matsushita T, Isobe N, Kira JI, et al.
- Journal Title
  
  Neurol Neuroimmunol Neuroinflamm
  
  Volume: 9 Issue: 3
- DOI
  10.1212/nxi.0000000000001147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-21K07464
[Journal Article] Serum anti-oligodendrocyte autoantibodies in patients with multiple sclerosis detected by a tissue-based immunofluorescence assay2021
- Author(s)
  Miyachi Y, Fujii T, Yamasaki R, Tsuchimoto D, Iinuma K, Sakoda A, Fukumoto S, Matsushita T, Masaki K, Isobe N, Nakabeppu Y, Kira J.
- Journal Title
  
  Front Neurol
  
  Volume: 12 Pages: 681980-681980
- DOI
  10.3389/fneur.2021.681980
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-21K07464, KAKENHI-PROJECT-21K15700
[Journal Article] High Resolution Haplotype Analyses of Classical HLA Genes in Families With Multiple Sclerosis Highlights the Role of HLA-DP Alleles in Disease Susceptibility2021
- Author(s)
  Osoegawa Kazutoyo、Creary Lisa E.、Montero-Mart?n Gonzalo、Mallempati Kalyan C.、Gangavarapu Sridevi、Caillier Stacy J.、Santaniello Adam、Isobe Noriko、Hollenbach Jill A.、Hauser Stephen L.、Oksenberg Jorge R.、Fern?ndez-Vi?a Marcelo A.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12
- DOI
  10.3389/fimmu.2021.644838
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07464
[Journal Article] A new clustering method identifies multiple sclerosis‐specific T‐cell receptors2021
- Author(s)
  Hayashi Fumie、Isobe Noriko、Glanville Jacob、Matsushita Takuya、Maimaitijiang Guzailiayi、Fukumoto Shoko、Watanabe Mitsuru、Masaki Katsuhisa、Kira Jun‐ichi
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 8 Issue: 1 Pages: 163-176
- DOI
  10.1002/acn3.51264
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K22910
[Journal Article] Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in Japanese multiple sclerosis2021
- Author(s)
  Hayashi F, Isobe N, Cossu D, Yokoyama K, Sakoda A, Matsushita T, Hattori N, Kira J
- Journal Title
  
  J Neuroimmunol
  
  Volume: 360 Pages: 577701-577701
- DOI
  10.1016/j.jneuroim.2021.577701
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-21K07464
[Journal Article] Update on the management of multiple sclerosis during the COVID-19 pandemic and post pandemic: An international consensus statement2021
- Author(s)
  Reyes Saul、Cunningham Anthony L.、Kalincik Tomas、Havrdova Eva Kubala、Isobe Noriko、Pakpoor Julia、Airas Laura、Bunyan Reem F.、van der Walt Anneke、Oh Jiwon、Mathews Joela、Mateen Farrah J.、Giovannoni Gavin
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 357 Pages: 577627-577627
- DOI
  10.1016/j.jneuroim.2021.577627
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07464
[Journal Article] HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica spectrum disorders based on Japan MS/NMOSD Biobank data2021
- Author(s)
  Watanabe M. Nakamura Y. Sato S. Niino M. Fukaura H. Tanaka M. Ochi H. et al
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 607-607
- DOI
  10.1038/s41598-020-79833-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07997, KAKENHI-PROJECT-20K07899, KAKENHI-PROJECT-18K10743, KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20H00529, KAKENHI-PROJECT-21K07467, KAKENHI-PROJECT-21K11165
[Journal Article] Environmental risk factors for multiple sclerosis in Japanese people2020
- Author(s)
  Sakoda A, Matsushita T, Nakamura Y, Watanabe M, Shinoda K, Masaki K, Isobe N, Yamasaki R, Kira J.
- Journal Title
  
  Multiple Sclerosis and Related Disorders
  
  Volume: 38 Pages: 101872-101872
- DOI
  10.1016/j.msard.2019.101872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19K07995, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-20K07889
[Journal Article] Contribution of cortical lesions to cognitive impairment in Japanese patients with multiple sclerosis2020
- Author(s)
  Shinoda K, et al.
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 5228-5228
- DOI
  10.1038/s41598-020-61012-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-19H01045
[Journal Article] Contribution of cortical lesions to cognitive impairment in Japanese patients with multiple sclerosis.2020
- Author(s)
  Shinoda K, Matsushita T, Nakamura Y, Masaki K, Sakai S, Nomiyama H, Togao O, Hiwatashi A, Niino M, Isobe N, Kira J.
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 5228-5228
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07529
[Journal Article] Two susceptible HLA-DRB1 alleles for multiple sclerosis differentially regulate anti-JC virus antibody serostatus along with fingolimod2020
- Author(s)
  Watanabe Mitsuru、Nakamura Yuri、Isobe Noriko、Tanaka Masami、Sakoda Ayako、Hayashi Fumie、Kawano Yuji、Yamasaki Ryo、Matsushita Takuya、Kira Jun-ichi
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 17 Issue: 1 Pages: 206-206
- DOI
  10.1186/s12974-020-01865-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07997, KAKENHI-PROJECT-19H01045
[Journal Article] Central nervous system-specific antinuclear antibodies in patients with multiple sclerosis2020
- Author(s)
  Fujii T, Yamasaki R, Miyachi Y, Nagata S, Maimaitijiang G, Nakamura Y, Shinoda K, Matsushita T, Isobe N, Kira J.
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 409 Pages: 116619-116619
- DOI
  10.1016/j.jns.2019.116619
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19K17037, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K20470
[Journal Article] Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis2020
- Author(s)
  Zhao Y, Yamasaki R, Yamaguchi H, Nagata S, Une H, Cui Y, Masaki K, Nakamuta Y, Iinuma K, Watanabe M, Matsushita T, Isobe N, Kira J.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 4 Pages: 2160-2169
- DOI
  10.1073/pnas.1901294117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-19H01045
[Journal Article] Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans2020
- Author(s)
  Nakatsuka Nathan、Patterson Nick、Patsopoulos Nikolaos A.、Altemose Nicolas、Tandon Arti、Beecham Ashley H.、McCauley Jacob L.、Isobe Noriko、Hauser Stephen、De Jager Philip L.、Hafler David A.、Oksenberg Jorge R.、Reich David
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 16902-16902
- DOI
  10.1038/s41598-020-74035-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529
[Journal Article] Painful trigeminal neuropathy associated with anti-Plexin D1 antibody2020
- Author(s)
  Fujii Takayuki、Yamasaki Ryo、Miyachi Yukino、Iinuma Kyoko、Hashimoto Yu、Isobe Noriko、Matsushita Takuya、Kira Jun-ichi
- Journal Title
  
  Neurology - Neuroimmunology Neuroinflammation
  
  Volume: 7 Issue: 5
- DOI
  10.1212/nxi.0000000000000819
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17037, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-18K07529
[Journal Article] Unique HLA haplotype associations in IgG4 anti-neurofascin 155 antibody-positive chronic inflammatory demyelinating polyneuropathy2020
- Author(s)
  Ogata H, Isobe N, Zhang X, Yamasaki R, Fujii T, Machida A, Morimoto N, Kaida K, Masuda T, Ando Y, Kuwahara M, Kusunoki S, Nakamura Y, Matsushita T, Kira J.
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 339 Pages: 577139-577139
- DOI
  10.1016/j.jneuroim.2019.577139
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-18K15454, KAKENHI-PROJECT-18K15455
[Journal Article] Risk HLA-DRB1 alleles differentially influence brain and lesion volumes in Japanese patients with multiple sclerosis2020
- Author(s)
  Fukumoto S, Nakamura Y, Watanabe M, Isobe N, Matsushita T, Sakoda A, Hiwatashi A, Shinoda K, Yamasaki R, Tsujino A, Kira J.
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 413 Pages: 116768-116768
- DOI
  10.1016/j.jns.2020.116768
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-19K21317
[Journal Article] Distinct microglial and macrophage distribution patterns in the concentric and lamellar lesions in Bal?'s disease and neuromyelitis optica spectrum disorders2020
- Author(s)
  Hayashida Shotaro、Masaki Katsuhisa、Suzuki Satoshi O.、Yamasaki Ryo、Watanabe Mitsuru、Koyama Sachiko、Isobe Noriko、Matsushita Takuya、Takahashi Kazuya、Tabira Takeshi、Iwaki Toru、Kira Jun‐ichi
- Journal Title
  
  Brain Pathology
  
  Volume: 30 Issue: 6 Pages: 1144-1157
- DOI
  10.1111/bpa.12898
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-19H01045
[Journal Article] Genetic factors for susceptibility to and manifestations of neuromyelitis optica2020
- Author(s)
  Matsushita Takuya、Masaki Katsuhisa、Isobe Noriko、Sato Shinya、Yamamoto Ken、Nakamura Yuri、Watanabe Mitsuru、Suenaga Toshihiko、Kira Jun‐ichi、the Japan Multiple Sclerosis Genetic Consortium
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 7 Issue: 11 Pages: 2082-2093
- DOI
  10.1002/acn3.51147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07869, KAKENHI-PROJECT-20K07889, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-18K07529
[Journal Article] Cerebrospinal fluid cytokine/chemokine/growth factor profiles in idiopathic hypertrophic pachymeningitis.2019
- Author(s)
  Zhang X, et al
- Journal Title
  
  J Neuroimmunol.
  
  Volume: 330 Pages: 38-43
- DOI
  10.1016/j.jneuroim.2019.01.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19663, KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-20K20470
[Journal Article] Discriminative clinical and neuroimaging features of motor-predominant hereditary diffuse leukoencephalopathy with axonal spheroids and primary progressive multiple sclerosis: A preliminary cross-sectional study2019
- Author(s)
  Saitoh B, Yamasaki R, Hiwatashi A, Matsushita T, Hayashi S, Mitsunaga Y, Maeda Y, Isobe N, Yoshida K, Ikeda S, Kira J.
- Journal Title
  
  Multiple Sclerosis and Related Disorders
  
  Volume: 31 Pages: 22-31
- DOI
  10.1016/j.msard.2019.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19K07996, KAKENHI-PROJECT-20K20470
[Journal Article] Long-term use of interferon-β in multiple sclerosis increases Vδ1(-)Vδ2(-)Vγ9(-) γδ T cells that are associated with a better outcome2019
- Author(s)
  Maimaitijiang G, Watanabe M, Shinoda K, Isobe N, Nakamura Y, Masaki K, Matsushita T, Yoshikai Y, Kira J.
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 16 Issue: 1 Pages: 179-179
- DOI
  10.1186/s12974-019-1574-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-20K20470, KAKENHI-PLANNED-16H06496
[Journal Article] Serum GFAP and neurofilament light as biomarkers of disease activity and disability in NMOSD2019
- Author(s)
  Watanabe M, Nakamura Y, Michalak Z, Isobe N, Barro C, Leppert D, Matsushita T, Hayashi F, Yamasaki R, Kuhle J, Kira J.
- Journal Title
  
  Neurology
  
  Volume: 93 Issue: 13
- DOI
  10.1212/wnl.0000000000008160
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-20K20470
[Journal Article] Intrathecal cytokine profile in neuropathy with anti‐neurofascin 155 antibody2019
- Author(s)
  Ogata H, Zhang X, Yamasaki R, Fujii T, Machida A, Morimoto N, Kaida K, Masuda T, Ando Y, Kuwahara M, Kusunoki S, Nakamura Y, Matsushita T, Isobe N, Kira J.
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 6 Issue: 11 Pages: 2304-2316
- DOI
  10.1002/acn3.50931
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-19H01045, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-18K15454, KAKENHI-PROJECT-18K15455
[Journal Article] Spinal cord involvement by atrophy and associations with disability are different between multiple sclerosis and neuromyelitis optica spectrum disorder2019
- Author(s)
  Nakamura Y, Liu Z, Fukumoto S, Shinoda K, Sakoda A, Matsushita T, Hayashida S, Isobe N, Watanabe M, Hiwatashi A, Yamasaki R, Kira J.
- Journal Title
  
  European Journal of Neurology
  
  Volume: 27 Issue: 1 Pages: 92-99
- DOI
  10.1111/ene.14038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07529, KAKENHI-PROJECT-20K20470, KAKENHI-PROJECT-19K21317
[Journal Article] The genetic diversity of multiple sclerosis risk among Hispanic and African American populations living in the United States2019
- Author(s)
  Beecham AH, Amezcua L, Chinea A, Manrique CP, Rubi C, Isobe N, Lund BT, Santaniello A, Beecham GW, Burchard EG, Comabella M, Patsopoulos N, Fitzgerald K, Calabresi PA, De Jager P, Conti DV, Delgado SR, Oksenberg J, McCauley JL.
- Journal Title
  
  Multiple Sclerosis Journal
  
  Volume: in press Issue: 11 Pages: 1329-1339
- DOI
  10.1177/1352458519863764
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529
[Journal Article] Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation2019
- Author(s)
  Didonna A, Canto E, Shams H, Isobe N, Zhao C, Caillier S, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR.
- Journal Title
  
  Journal of Autoimmunity
  
  Volume: 101 Pages: 56-69
- DOI
  10.1016/j.jaut.2019.04.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529
[Journal Article] Oral phase dysphagia in facial onset sensory and motor neuronopathy2018
- Author(s)
  Watanabe M, Shiraishi W, Yamasaki R, Isobe N, Sawatsubashi M, Yasumatsu R, Nakagawa T, Kira, JI.
- Journal Title
  
  Brain and Behavior
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-17H06938
[Journal Article] Association of Decreased Percentage of Vδ2+Vγ9+ γδ T Cells With Disease Severity in Multiple Sclerosis2018
- Author(s)
  Maimaitijiang G, Shinoda K, Nakamura Y, Masaki K, Matsushita T, Isobe N, Yamasaki R, Yoshikai Y, Kira J.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 1-10
- DOI
  10.3389/fimmu.2018.00748
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06938, KAKENHI-PROJECT-15K09341, KAKENHI-PLANNED-16H06496, KAKENHI-PROJECT-16H02657, KAKENHI-PROJECT-17K19663
[Journal Article] Genetics in multiple sclerosis: Updates in the era of big data2018
- Author(s)
  Isobe N.
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 9 Issue: 1 Pages: 19-24
- DOI
  10.1111/cen3.12443
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06938
[Journal Article] Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients2018
- Author(s)
  Canto E, MS-EPIC Study Group、Isobe N, Didonna A, Hauser SL, Oksenberg JR.
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 15 Issue: 1 Pages: 72-72
- DOI
  10.1186/s12974-018-1105-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06938
[Journal Article] Emerging importance of big data in neuroimmunological research2018
- Author(s)
  Isobe N.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 9 Issue: 1 Pages: 3-3
- DOI
  10.1111/cen3.12451
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06938
[Journal Article] MS（multiple sclerosis）とCIS（clinically isolated syndrome）の最新の診断基準．2017
- Author(s)
  磯部紀子、吉良潤一．
- Journal Title
  
  脊椎脊髄ジャーナル
  
  Volume: 30 Pages: 743-747
- Data Source
  KAKENHI-PROJECT-17H06938
[Journal Article] CONGRESS REPORT; American Academy of Neurology 2017 Annual Meeting.2017
- Author(s)
  Isobe N.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 8 Pages: 273-275
- Data Source
  KAKENHI-PROJECT-17H06938
[Presentation] 中枢神経自己免疫性疾患におけるステロイド使用と椎体骨折との関連2024
- Author(s)
  吉良雄一、山崎友梨乃、渡邉充、田中栄蔵、篠田紘司、眞﨑勝久、磯部紀子
- Organizer
  神経免疫班合同半会議
- Data Source
  KAKENHI-PROJECT-23K06964
[Presentation] 神経免疫疾患における補体の役割2023
- Author(s)
  磯部　紀子
- Organizer
  第59回日本補体学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] 多発性硬化症におけるγδ型T細胞の病態関与と治療反応性バイオマーカーとしての有用性の検討2023
- Author(s)
  渡邉充、松尾江梨子、篠田紘司、田中栄蔵、小柳彩乃、福元尚子、眞﨑勝久、松下拓哉、吉良潤一、磯部紀子
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06964
[Presentation] 大きく変わった多発性硬化症治療の現在2023
- Author(s)
  磯部　紀子
- Organizer
  日本神経学会九州地区生涯教育講演会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] 多発性硬化症における頭部全脊髄MRIでの多発T2病変とフマル酸ジメチルによる再発抑制効果との関連性の検討2023
- Author(s)
  田中栄蔵、渡邉充、篠田紘司、眞﨑勝久、松下拓哉、磯部紀子
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06964
[Presentation] Clinical Features of Eight Patients Presenting with Concentric Lesions like Balo's Concentric Sclerosis2023
- Author(s)
  Kazunori Iwao, Katsuhisa Masaki, Yuichi Kira, Eizo Tanaka, Mitsuru Watanabe, Koji Shinoda, Takeshi Miura, Noriko Isobe
- Organizer
  the 15th Congress of the Pan-Asian Committee on Treatment and Research in Multiple Sclerosis (PACTRIMS) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06964
[Presentation] 多発性硬化症の診療2023
- Author(s)
  磯部　紀子
- Organizer
  第 2 回神経免疫診療医育成セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] The Genetic of Neuroimmunology2023
- Author(s)
  Noriko Isobe
- Organizer
  ASIA PACIFIC School of Neuroimmunology (APSNI)
- Invited
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] Anti-Annexin A2 autoantibodies relate to neuropathic pain2023
- Author(s)
  Kaoru Kashu, Takayuki Fujii, Hidenori Ogata, Sato Yoshidomi, Ryo Yamasaki, Noriko Isobe.
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K06945
[Presentation] 多発性硬化症におけるγδ型T細胞の病態関与と治療反応性バイオマーカーとしての有用性の検討2023
- Author(s)
  渡邉充, 松尾江梨子, 篠田紘司, 田中栄蔵, 小栁文乃, 福元尚子, 眞﨑勝久, 松下拓也, 吉良潤一, 磯部紀子
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] 末梢性神経障害性疼痛患者における抗Annexin A2抗体の保有率および抗体陽性患者の臨床的特徴の解明2023
- Author(s)
  賀集薫、藤井敬之、緒方英紀、吉富小都、山﨑亮、磯部紀子.
- Organizer
  第34回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06945
[Presentation] An Update on The Treatment Options for Multiple Sclerosis in Asian Population2023
- Author(s)
  Noriko Isobe
- Organizer
  Malang Integrated Education in Neurology Meeting XI (MIELUM-XI)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] 神経障害性疼痛患者における抗Annexin A2抗体の保有率および抗体陽性患者の臨床的特徴の解明2023
- Author(s)
  賀集薫、藤井敬之、緒方英紀、吉富小都、山﨑亮、磯部紀子.
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06945
[Presentation] Factors Associated with Glatiramer Acetate Efficacy in Japanese Multiple Sclerosis.2022
- Author(s)
  Eizo Tanaka, Mitsuru Watanabe, Shoko Fukumoto, Koki Suezumi, Katsuhisa Masaki, Takuya Matsushita, Noriko Isobe.
- Organizer
  14th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] Association between HLA subtype and efficacy of glatiramer acetate in Japanese multiple sclerosis2022
- Author(s)
  田中栄蔵、渡邉充、福元尚子、眞﨑勝久、松下拓也、磯部紀子
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Genetic and environmental factors in multiple sclerosis.2022
- Author(s)
  Noriko Isobe
- Organizer
  18th Asian Oceanian Congress of Neurology and 29th Annual Conference of the Indian Academy of Neurology
- Invited
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] Association between HLA subtype and efficacy of glatiramer acetate in Japanese multiple sclerosis.2022
- Author(s)
  Eizo Tanaka, Mitsuru Watanabe, Shoko Fukumoto, Katsuhisa Masaki, Takuya Matsushita, Noriko Isobe
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] 多発性硬化症の病因と治療戦略2022
- Author(s)
  磯部紀子
- Organizer
  2021年度日本神経学会北海道地区生涯教育講演会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] 日本人多発性硬化症患者における高次脳機能とMRIパラメータ変化との関連.2022
- Author(s)
  福元尚子, 渡邉充, 新野正明, 松下拓也, 眞﨑勝久, 迫田礼子, 林史恵, 吉良潤一, 磯部紀子
- Organizer
  第34回日本神経免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] Low gray matter volume can predict cognitive decline in Japanese patients with multiple sclerosis.2022
- Author(s)
  Shoko Fukumoto, Mitsuru Watanabe, Masaaki Niino, Katsuhisa Masaki, Takuya Matsushita, Ayako Sakoda, Fumie Hayashi, Jun-ichi Kira, Noriko Isobe
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] 日本人多発性硬化症患者におけるグラチラマー酢酸塩の有効性に関与する因子の検討.2022
- Author(s)
  田中栄蔵, 渡邉充, 福元尚子, 眞﨑勝久, 松下拓也, 磯部紀子
- Organizer
  第34回日本神経免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] Dimethyl fumarate treatment showed unique change of γδ T cell subsets in multiple sclerosis patients2022
- Author(s)
  Mitsuru Watanabe, Eriko Matsuo, Shoko Fukumoto, Eizo Tanaka, Katsuhisa Masaki, Takuya Matsushita, Jun-ichi Kira, Noriko Isobe
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07351
[Presentation] 多発性硬化症の病因・病態と治療2022
- Author(s)
  磯部　紀子
- Organizer
  第50回日本臨床免疫学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] Dimethyl fumarate treatment showed unique change of γδ T cell subsets in multiple sclerosis patients2022
- Author(s)
  渡邉充、松尾江梨子、福元尚子、田中栄蔵、眞﨑勝久、松下拓也、吉良潤一、磯部紀子
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Multiple sclerosis: strategies for future precision medicine2021
- Author(s)
  Noriko Isobe
- Organizer
  The 33rd Annual Meeting of the Japanese Society for Neuroimmunology
- Invited
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] Iguratimod improves a secondary progressive multiple sclerosis (SPMS) model by therapeutic administration.2021
- Author(s)
  Satoshi Nagata, Ryo Yamasaki, Ezgi Ozdemir, Hiroo Yamaguchi, Katsuhisa Masaki, Jun-ichi Kira, Noriko Isobe:
- Organizer
  15th Congress of the International Society of Neuroimmunology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] 再発寛解型多発性硬化症におけるfingolimod内服下での喫煙と再発の検討2021
- Author(s)
  田中栄蔵、渡邉充、松下拓也、吉良潤一、磯部紀子
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Smoking is a risk factor of relapse in patients with relapsing-remitting multiple sclerosis under fingolimod treatment2021
- Author(s)
  Eizo Tanaka, Mitsuru Watanabe, Katsuhisa Masaki, Takuya Matsushita, Noriko Isobe
- Organizer
  ECTRIMS 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Smoking effect on disease activity in relapsing-remitting multiple sclerosis patients treated with fingolimod or dimethyl fumarate2021
- Author(s)
  Eizo Tanaka, Mitsuru Watanabe, Shoko Fukumoto, Katsuhisa Masaki, Takuya Matsushita, Noriko Isobe
- Organizer
  PACTRIMS 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] 多発性硬化症において期待される新たな治療戦略2021
- Author(s)
  磯部紀子
- Organizer
  第39回日本神経治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] Correlation between cognitive and brain MRI parameters in Japanese patients with multiple sclerosis.2021
- Author(s)
  Shoko Fukumoto, Mitsuru Watanabe, Masaaki Niino, Katsuhisa Masaki, Takuya Matsushita, Ayako Sakoda, Fumie Hayashi, Jun-ichi Kira, Noriko Isobe
- Organizer
  ECTRIMS 2021 The Digital Experience 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Association between smoking and relapse in patients with relapsing-remitting multiple sclerosis under fingolimod treatment2021
- Author(s)
  Eizo Tanaka, Mitsuru Watanabe, Takuya Matsushita, Noriko Isobe
- Organizer
  WCN 2021 (XXV World Congress of Neurology)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Continued increase of multiple sclerosis and neuromyelitis optica in the 5th nationwide survey2021
- Author(s)
  Noriko Isobe1 Masaaki Niino, Mitsuru Watanabe, Ichiro Nakashima, Takuya Matsushita, Yasunari Sakai, Jin Nakahara, Izumi Kawachi, Hirofumi Ochi, Yuji Nakatsuji, Juichi Fujimori, Kenji Kufukihara, Koshi Nakamura, Kiyomi Sakata, Makoto Matsui, Jun-ichi Kira
- Organizer
  62nd Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] Epidemiology of neuromyelitis optica spectrum disorders2021
- Author(s)
  Noriko Isobe
- Organizer
  62nd Annual Meeting of the Japanese Society of Neurology
- Invited
- Data Source
  KAKENHI-PROJECT-21K07464
[Presentation] 第5回全国調査が示す多発性硬化症・視神経脊髄炎総患者数の増加．2020
- Author(s)
  磯部紀子、新野正明、松下拓也、中村優理、中島一郎、渡邉充、酒井康成、迫田礼子、中原仁、河内泉、越智博文、中辻裕司、福元尚子、林史恵、中村好一、中村幸志、坂田清美、嶋田莉奈子、松井真、吉良潤一．
- Organizer
  第32回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] Frequent subclinical cranial nerve involvement in anti-neurofascin 155 antibody-positive CIDP2020
- Author(s)
  Ogata H, Zhang X, Inamizu S, Yamasaki R, Matsushita T, Isobe N, Kira J
- Organizer
  2020 Peripheral Nerve Society Annual Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Continued increase of multiple sclerosis and neuromyelitis optica in Japan. Updates from the 5th Nationwide survey2020
- Author(s)
  Kira J, Isobe N, Niino M, et al.
- Organizer
  145th Annual Meeting of the American Neurological Association 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Two subtypes of anti-neurofascin 155/contactin-1 antibody-negative CIDP by CSF cytokine profiling2020
- Author(s)
  Zhang X, Ogata H, Yamasaki R, Kaida K, Kuwahara M, Kusunoki S, Matsushita T, Isobe N, Kira J
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Serum glial fibrillary acidic protein, but not S100B or neurofilament light chain predicts future relapses in neuromyelitis optica spectrum disorders.2020
- Author(s)
  Watanabe M, Isobe N, Matsushita T, Maceski AM, Nakamura Y, Masaki K, Kira J, Leppert D, Kuhle J
- Organizer
  MSVirtual2020 (8th Joint ACTRIMS-ECTRIMS Meeting)
- Invited
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] 免疫介在性疾患の病因追究手段としてのHLAその他の遺伝子解析手法の原理と臨床的意義づけ2020
- Author(s)
  磯部紀子
- Organizer
  第32回日本神経免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] Protective effect of rice on multiple sclerosis susceptibility via CD4+ effector T cell reduction2020
- Author(s)
  Sakoda A, Matsushita T, Watanabe M, Maimaitijiang G, Shinoda K, Isobe N, Kira J.
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Genetic approach for disease heterogeneity of multiple sclerosis: for the era of precision medicine. Perspectives on Personalized Medicine for Multiple Sclerosis.2019
- Author(s)
  Isobe N.
- Organizer
  12th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] Genetic studies on Japanese multiple sclerosis and neuromyelitis optica spectrum disorders.2019
- Author(s)
  Takuya Matsushita, Shinya Sato, Ken Yamamoto, Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Jun-ichi Kira, the Japan Multiple Sclerosis Genetics Consortium
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology. 2019.5.22. Osaka, Japan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] 日本人多発性硬化症における疾患修飾薬関連進行性多巣性白質脳症発症リスクにHLAアリル多型が関与する2019
- Author(s)
  渡邉充、中村優理、磯部紀子、田中正美、松下拓也、河野祐治、迫田礼子、林史恵、吉良潤一
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] 表現型不一致の一卵性品胎における多発性硬化症関連Ｔ細胞受容体レパトア解析．2019
- Author(s)
  磯部紀子、林史恵、渡邉充、松下拓也、岡本幸市、吉良潤一．
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] 日本人における視神経脊髄炎の環境要因についての検討2019
- Author(s)
  迫田礼子、松下拓也、中村優理、渡邉充、磯部紀子、吉良潤一
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Genome-wide association studies for neuromyelitis optica and the clinical phenotypes.2019
- Author(s)
  Takuya Matsushita, Shinya Sato, Ken Yamamoto, Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Jun-ichi Kira, the Japan Multiple Sclerosis Genetics Consortium
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology. 2019.5.22. Osaka, Japan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Central nervous system-specific antinuclear antibodies associated with secondary progression and greater disability in MS.2019
- Author(s)
  Takayuki Fujii, Ryo Yamasaki, Yukino Miyachi, Satoshi Nagata, Guzailiayi Maimaitijiang, Yuri Nakamura, Koji Shinoda, Takuya Matsushita, Noriko Isobe, Jun-ichi Kira
- Organizer
  ECTRIMS 2019. 2019.9.13. Stockholm, Sweden.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Environmental factors for neuromyelitis optica spectrum disorders (NMOSD) in Japanese population.2019
- Author(s)
  Ayako Sakoda, Takuya Matsushita, Yuri Nakamura, Mitsuru Watanabe, Koji Shinoda, Noriko Isobe, Jun-ichi Kira
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology. 2019.5.24. Osaka, Japan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] HLA-DRB1*04:05陽性MS患者におけるサイトメガロウイルス（CMV）関連T細胞受容体の同定．2019
- Author(s)
  林史恵、磯部紀子、Jacob Glanville、松下拓也、吉良潤一．
- Organizer
  第31回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] A novel risk molecule associated with neurological impairment identified by genome-wide association studies for neuromyelitis optica.2019
- Author(s)
  Takuya Matsushita, Katsuhisa Masaki, Shinya Sato, Ken Yamamoto, Mitsuru Watanabe, Yuri Nakamura, Noriko Isobe, Jun-ichi Kira, the Japan Multiple Sclerosis Genetics Consortium
- Organizer
  The 6th MS Summer College in Fukuoka. 2019.8.3. Fukuoka, Japan.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] T cell receptor repertoire in a monozygotic triplet discordant for multiple Sclerosis.2019
- Author(s)
  Isobe N, Hayashi F, Matsushita T, Okamoto K, Kira JI.
- Organizer
  35th Congress of The European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] 抗neurofascin 155抗体関連ニューロパチー全国調査結果.2019
- Author(s)
  緒方英紀, 山﨑亮, 磯部紀子, 角谷真人, 海田賢一, 松井真, 桑原聡, 楠進, 吉良潤一
- Organizer
  第31回日本神経免疫学会学術集会. 2019.9.26. 千葉.
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Increase of Mycobacterium avium subsp. Paratuberculosis (MAP) antibody in multiple sclerosis2019
- Author(s)
  Isobe N, Hayashi F, Cossu D, Yokoyama K, Maimatijiang G, Nakamura Y, Matsushita T, Kira JI.
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] 米食の予防効果は多発性硬化症でみられるが視神経脊髄炎関連疾患ではみられない2019
- Author(s)
  迫田礼子、松下拓也、中村優理、渡邉充、磯部紀子、吉良潤一
- Organizer
  第37回日本神経治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Increase of EBV lytic infection in Japanese patients with multple sclerosis.2019
- Author(s)
  Isobe N, Dilek HF, Sakoda A, Hayashi F, Watanabe M, Matsushita T, Kira JI.
- Organizer
  The 12th Congress of the PACTRIMS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] Progressive multifocal leukoencephalopathy in the era of disease-modifying therapies. Genetic backgrounds of Japanese MS and JC virus antibody.2019
- Author(s)
  Isobe N.
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] The first nationwide survey results of IgG4 anti-neurofascin155 (NF155) antibody-positive neuropathy.2019
- Author(s)
  Hidenori Ogata, Ryo Yamasaki, Masato Kadoya, Kenichi Kaida, Makoto Matsui, Satoshi Kuwabara, Susumu Kusunoki, Noriko Isobe, Jun-ichi Kira
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology. 2019.5.22. Osaka, Japan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01045
[Presentation] Effect of HLA class II alleles on JCV infection in Japanese patients with multiple sclerosis2019
- Author(s)
  Watanabe M, Nakamura Y, Isobe N, Tanaka M, Sakoda A, Hayashi F, Matsushita T, Kira J.
- Organizer
  35th Congress of ECTRIMS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Disease-characteristic TCRs recognize CMV in Japanese MS with HLA-DRB1*04:05; a novel approach with GLIPH.2019
- Author(s)
  Hayashi F, Isobe N, Glanville J, Matsushita T, Kira J.
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] Environmental factors for neuromyelitis optica spectrum disorders (NMOSD) in Japanese population.2019
- Author(s)
  Sakoda A, Matsushita T, Nakamura Y, Watanabe M, Shinoda K, Isobe N, Kira J.
- Organizer
  60th Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-19K07995
[Presentation] Genetic risk factors for MS in non-Caucasian populations.2018
- Author(s)
  Isobe N.
- Organizer
  10th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06938
[Presentation] Parent-of-origin genetic effects in multiple sclerosis.2018
- Author(s)
  Isobe N, Tsai A, Caillier SJ, Santaniello A, Kira JI, Hauser SL, Oksenberg JR.
- Organizer
  34th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] パスウェイバーデン解析による多発性硬化症リスク遺伝子の疾患多様性への寄与の検討2018
- Author(s)
  磯部紀子、UCSF MS EPIC team
- Organizer
  第29回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06938
[Presentation] Parent-of-origin effects in multiple sclerosis2018
- Author(s)
  Isobe N, Tsai A, Caillier SJ, Santaniello A, Kira J, Hauser SL, Oksenberg JR.
- Organizer
  第59回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] 片親起源効果を用いた新規多発性硬化症リスク遺伝子の探索2018
- Author(s)
  磯部紀子、Andy Tsai、Stacy J Caillier、Adam Santaniello、松下拓也、吉良潤一、Stephen L. Hauser、Jorge R. Oksenberg．
- Organizer
  第30回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] Multiple sclerosis: from genetics to epigenetics.2018
- Author(s)
  Isobe N.
- Organizer
  The 6th LingNan-Internatinoal Neurology and Neuroimmunology Meeting (LINIM, 2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07529
[Presentation] Genetic descriptors of a multiple sclerosis cohort2018
- Author(s)
  Isobe N, for the University of California San Francisco MS-EPIC team.
- Organizer
  The 69th American Academy of Neurology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06938

1. Matsushita Takuya (00533001)

# of Collaborated Projects: 9 results

# of Collaborated Products: 57 results
2. Watanabe Mitsuru (30748009)

# of Collaborated Projects: 8 results

# of Collaborated Products: 34 results
3. Kira Jun-ichi (40183305)

# of Collaborated Projects: 5 results

# of Collaborated Products: 44 results
4. 山崎亮 (10467946)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
5. 中村優理 (40822375)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
6. 真崎勝久 (90612903)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
7. 藤井敬之 (30822481)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
8. 緒方英紀 (90778838)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. Maimaitijiang Guzailiayi (60887107)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. Kawano Yuji (20333479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Chishaki Akiko (60216497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 萬谷博 (20321870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 海田賢一 (40531190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. 加藤聖子 (10253527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 澤渡浩之 (30757034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 錦谷まりこ (40327333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 工藤孔梨子 (50644796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 中島直樹 (60325529)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 川波祥子 (70449940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 樗木浩朗 (70607093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 伊豆倉理江子 (80805292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 永吉絹子 (90761015)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 矢口貴博 (30434947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 今村友裕 (30725122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 張旭 (60892669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 松本省二 (00570772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 篠田紘司 (70747998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Isobe Noriko 磯部 紀子

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Elucidation of inflammation regulatory mechanisms in central nervous system autoimmune diseasesPrincipal Investigator

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Identification of interaction between sex chromosomes and HLA in central nervous system autoimmune diseasesPrincipal Investigator

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Parent-of-origin effect in multiple sclerosis susceptibilityPrincipal Investigator

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パスウェイバーデン解析に基づく多発性硬化症リスク遺伝子の疾患多様性への寄与の解明Principal Investigator

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[Journal Article] 多発性硬化症のコホート研究2024

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[Journal Article] Effect of smoking on disease activity in multiple sclerosis patients treated with dimethyl fumarate or fingolimod2023

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Isobe Noriko 磯部紀子