Okita Naoyuki 沖田直之

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OKITA Naoyuki 沖田直之

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Researcher Number	60453841
Other IDs
Affiliation (Current)	2025: 山陽小野田市立山口東京理科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 山陽小野田市立山口東京理科大学, 薬学部, 講師 2017: 公益財団法人佐々木研究所, 附属研究所, 部長(移行) 2015: 公益財団法人佐々木研究所, 附属佐々木研究所, 研究員 2014 – 2015: 公益財団法人佐々木研究所, 付属研究所, 研究員 2013 – 2015: 公益財団法人佐々木研究所, その他部局等, 研究員 2011 – 2013: 東京理科大学, 薬学部, 助教 2008: 東京理科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Metabolomics / Medical pharmacy Except Principal Investigator Experimental pathology / Basic Section 59040:Nutrition science and health science-related / Applied health science
Keywords	Principal Investigator 2型糖尿病 / 膵島 / 機能疲弊 / 分化転換 / 膵島障害 / 膵島傷害 / 膵島ニッチ / ストレス応答 / Nutlin-3a / Parp1 … More / プロテアソーム / p53 / 虚血再灌流障害 / Caylin2 / Nutlin3a / PARP1 … More Except Principal Investigator カロリー制限 / ミトコンドリア / 脂肪組織 / ミトファジー / ミトコンドリアシグナルペプチダーゼ / Mipep / 肥満症 / 脂肪細胞 / ノックアウトマウス / 寿命 / 老化 / リポジストロフィー / エネルギー代謝 / MIPEP / リポディストロフィー / スプライシング制御 / 脂質代謝 / スプライシング / 体内時計 / リソソーム / PARIS / ミトコンドリア生合成 / PINK1/PARKIN / SIRT3 / ミトコンドリア品質管理 / ミトコンドリア病 / ミトコンドリアシグナルペプチターゼ / ミトコンドリアの品質管理 / Srebp-1c / 白色脂肪組織（WAT） / カロリーの制限（CR） / Sirt3 / シグナルペプチダーゼ / 品質管理 / ユビキチンリガーゼ / WWP1 / p53 / 炎症 / 細胞傷害 / LXR / SREBPI / SREBP1 Less

膵β細胞における機能疲弊と分化転換の可塑性・可逆性が織りなす糖尿病病態の多様性Principal Investigator
- Principal Investigator
  
  沖田直之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Reguratory mechanisms of lifespan by altered energy metabolism via splicing control
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science
Molecular basis of transdifferentiation mechanism in type 2 diabetes mellitus ~for establishment of personalized therapy for type 2 diabetes~Principal Investigator
- Principal Investigator
  
  OKITA Naoyuki
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Dysregulation of lysosome/mitochondrial interaction in obese adipose tissue
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo University of Science
Comprehensive mitochondrial quality control and its collapse in metabolic diseases
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science
Challenge for diabetes therapy based on understanding of stress signals in pancreatic islet nichePrincipal Investigator
- Principal Investigator
  
  Okita Naoyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Sasaki Foundation
Functional Analysis of a Novel Obesity-associated E3 Ubiquitin Ligase WWP1
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science
Development of therapeutic agents for ischemia/reperfusion injury utilizing a novel regulatory mechanism of Parp1Principal Investigator
- Principal Investigator
  
  OKITA Naoyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tokyo University of Science
Suppressed cellular damage and inflammation, and altered metabolism by caloric restriction via SREBP1/LXR
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science

[Book] AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging (chapter Autophagy in adipose tissue )2016
- Author(s)
  Mizunoe Y, Sudo Y, Okita N, Higami Y
- Total Pages
  23
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-25860759
[Book] Section 15. Other determinants of sensitivity, PARP Inhibitors for Cancer Therapy (Edited by Curtin N, Sharma R)2015
- Author(s)
  Okita N, Shibata A
- Total Pages
  593
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25860759
[Journal Article] Bioactive TNIIIA2 Sequence in Tenascin-C Is Responsible for Macrophage Foam Cell Transformation; Potential of FNIII14 Peptide Derived from Fibronectin in Suppression of Atherosclerotic Plaque Formation2024
- Author(s)
  Iyoda Takuya、Ohishi Asayo、Wang Yunong、Yokoyama Miyabi-Shara、Kazama Mika、Okita Naoyuki、Inouye Sachiye、Nakagawa Yoshimi、Shimano Hitoshi、Fukai Fumio
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 3 Pages: 1825-1825
- DOI
  10.3390/ijms25031825
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K10894, KAKENHI-PROJECT-22H00474
[Journal Article] Heat shock‐induced heme oxygenase‐1 expression in a mouse hepatoma cell line is dependent on <scp>HSF1</scp> and modified by <scp>NRF2</scp> and <scp>BACH1</scp>2022
- Author(s)
  Inouye Sachiye、Kubo Takanori、Miyamoto Takafumi、Iyoda Takuya、Okita Naoyuki、Akagi Reiko
- Journal Title
  
  Genes to Cells
  
  Volume: 27 Issue: 12 Pages: 719-730
- DOI
  10.1111/gtc.12986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-21K19064, KAKENHI-PROJECT-23K23562, KAKENHI-PROJECT-23K24297
[Journal Article] Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids2022
- Author(s)
  Tagawa Ryoma、Kobayashi Masaki、Sakurai Misako、Yoshida Maho、Kaneko Hiroki、Mizunoe Yuhei、Nozaki Yuka、Okita Naoyuki、Sudo Yuka、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1793-1793
- DOI
  10.3390/ijms23031793
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-22K17814, KAKENHI-PROJECT-20K19686
[Journal Article] Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle2021
- Author(s)
  Yuhei Mizunoe, Masaki Kobayashi, Hiroki Saito, Akifumi Goto, Ryota Migitaka, Kumi Miura, Naoyuki Okita, Yuka Sudo, Ryoma Tagawa, Miki Yoshida, Ai Umemori, Yoshimi Nakagawa, Hitoshi Shimano, Yoshikazu Higami
- Journal Title
  
  Experimental gerontology
  
  Volume: 154 Pages: 111519-111519
- DOI
  10.1016/j.exger.2021.111519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J00407, KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
[Journal Article] Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes2020
- Author(s)
  Kobayashi Masaki、Yasukawa Hiromine、Arikawa Tomoya、Deguchi Yusuke、Mizushima Natsumi、Sakurai Misako、Onishi Shoichi、Tagawa Ryoma、Sudo Yuka、Okita Naoyuki、Higashi Kyohei、Higami Yoshikazu
- Journal Title
  
  FEBS Open Bio
  
  Volume: 11 Issue: 1 Pages: 185-194
- DOI
  10.1002/2211-5463.13055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
[Journal Article] WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism2020
- Author(s)
  Hoshino Shunsuke、Kobayashi Masaki、Tagawa Ryoma、Konno Ryutaro、Abe Takuro、Furuya Kazuhiro、Miura Kumi、Wakasawa Hiroki、Okita Naoyuki、Sudo Yuka、Mizunoe Yuhei、Nakagawa Yoshimi、Nakamura Takeshi、Kawabe Hiroshi、Higami Yoshikazu
- Journal Title
  
  FEBS Open Bio
  
  Volume: 10 Issue: 3 Pages: 306-315
- DOI
  10.1002/2211-5463.12795
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
[Journal Article] Is PARP-1 Inhibitor (Nutlin3a) Effective on Hepatic Ischemia-Reperfusion Injury?2020
- Author(s)
  Kawahara Daisuke、Yamanouchi Kosho、Okita Naoyuki、Higami Yoshikazu、Inoue Yusuke、Ito Shinichiro、Hidaka Masaaki、Kanetaka Kengo、Fujita Fumihiko、Eguchi Susumu
- Journal Title
  
  Surgery, Gastroenterology and Oncology
  
  Volume: 25 Issue: 4 Pages: 189-189
- DOI
  10.21614/sgo-25-4-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11119
[Journal Article] Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes2020
- Author(s)
  Mizunoe Yuhei、Kobayashi Masaki、Hoshino Shunsuke、Tagawa Ryoma、Itagawa Rei、Hoshino Ayana、Okita Naoyuki、Sudo Yuka、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 634-634
- DOI
  10.1038/s41598-020-57428-6
- NAID
  120007165462
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-18K17953, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-17H02179
[Journal Article] Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line2020
- Author(s)
  Kobayashi Masaki、Ishizaki Yuka、Owaki Mika、Matsumoto Yoko、Kakiyama Yuri、Hoshino Shunsuke、Tagawa Ryoma、Sudo Yuka、Okita Naoyuki、Akimoto Kazunori、Higami Yoshikazu
- Journal Title
  
  Oncotarget
  
  Volume: 11 Issue: 18 Pages: 1653-1665
- DOI
  10.18632/oncotarget.27581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20K07207, KAKENHI-PROJECT-20K19686
[Journal Article] Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue.2019
- Author(s)
  Namiki Fujii, Seira Uta, Masaki Kobayashi, Tsugumichi Sato, Naoyuki Okita, Yoshikazu Higami
- Journal Title
  
  Experimental gerontology
  
  Volume: 118 Pages: 55-64
- DOI
  10.1016/j.exger.2019.01.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
[Journal Article] Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes2019
- Author(s)
  Kobayashi Masaki、Hoshino Shunsuke、Abe Takuro、Okita Naoyuki、Tagawa Ryoma、Nagai Wataru、Konno Ryutaro、Suzuki Yuki、Furuya Kazuhiro、Ishikawa Natsumi、Okado Hitoshi、Oku Misako、Iwamoto Machiko、Miura Yuri、Sudo Yuka、Higami Yoshikazu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 508 Issue: 1 Pages: 117-122
- DOI
  10.1016/j.bbrc.2018.11.127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-17H02179
[Journal Article] ウエスタンブロッティングの改変によるペプチドホルモンの分離検出2018
- Author(s)
  沖田直之
- Journal Title
  
  理大科学フォーラム
  
  Volume: 35 Pages: 40-45
- NAID
  40021694698
- Data Source
  KAKENHI-PROJECT-18K11119
[Journal Article] Differential response to caloric restriction of retroperitoneal, epididymal, and subcutaneous adipose tissue depots in rats2018
- Author(s)
  Narita Takumi、Kobayashi Masaki、Itakura Kaho、Itagawa Rei、Kabaya Riho、Sudo Yuka、Okita Naoyuki、Higami Yoshikazu
- Journal Title
  
  Exp Gerontol
  
  Volume: 104 Pages: 127-137
- DOI
  10.1016/j.exger.2018.01.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways2018
- Author(s)
  Mizunoe Yuhei、Kobayashi Masaki、Sudo Yuka、Watanabe Shukoh、Yasukawa Hiromine、Natori Daiki、Hoshino Ayana、Negishi Arisa、Okita Naoyuki、Komatsu Masaaki、Higami Yoshikazu
- Journal Title
  
  Redox Biol.
  
  Volume: 15 Pages: 115-124
- DOI
  10.1016/j.redox.2017.09.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-17H02179
[Journal Article] Taurine is an amino acid with the ability to activate autophagy in adipocytes.2018
- Author(s)
  Kaneko H, Kobayashi M, Mizunoe Y, Yoshida M, Yasukawa H, Hoshino S, Itagawa R, Furuichi T, Okita N, Sudo Y, Imae M, Higami Y
- Journal Title
  
  Amino Acids
  
  Volume: 50 Issue: 5 Pages: 527-535
- DOI
  10.1007/s00726-018-2550-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia2018
- Author(s)
  Sudo Yuka、Otsuka Hiroki、Miyakawa Ryota、Goto Akifumi、Kashiwase Yohei、Terawaki Kiyoshi、Miyano Kanako、Hirao Yuto、Taki Kanari、Tagawa Ryoma、Kobayashi Masaki、Okita Naoyuki、Uezono Yasuhito、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 12 Pages: 3852-3852
- DOI
  10.3390/ijms19123852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
[Journal Article] Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice2017
- Author(s)
  Mizunoe Yuhei、Sudo Yuka、Okita Naoyuki、Hiraoka Hidenori、Mikami Kentaro、Narahara Tomohiro、Negishi Arisa、Yoshida Miki、Higashibata Rikako、Watanabe Shukoh、Kaneko Hiroki、Natori Daiki、Furuichi Takuma、Yasukawa Hiromine、Kobayashi Masaki、Higami Yoshikazu
- Journal Title
  
  Autophagy
  
  Volume: 13 Issue: 4 Pages: 642-653
- DOI
  10.1080/15548627.2016.1274850
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Modified Western blotting for insulin and other diabetes-associated peptide hormones.2017
- Author(s)
  Okita N, Higami Y, Fukai F, Kobayashi M, Mitarai M, Sekiya T, Sasaki T.
- Journal Title
  
  Sci Rep
  
  Volume: 7:6949 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-017-04456-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461346, KAKENHI-PROJECT-17H02179
[Journal Article] Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction2017
- Author(s)
  Fujii Namiki、Narita Takumi、Okita Naoyuki、Kobayashi Masaki、Furuta Yurika、Chujo Yoshikazu、Sakai Masahiro、Yamada Atsushi、Takeda Kanae、Konishi Tomokazu、Sudo Yuka、Shimokawa Isao、Higami Yoshikazu
- Journal Title
  
  Aging Cell
  
  Volume: 16 Issue: 3 Pages: 508-517
- DOI
  10.1111/acel.12576
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction2017
- Author(s)
  Kobayashi Masaki、Takeda Kanae、Narita Takumi、Nagai Keita、Okita Naoyuki、Sudo Yuka、Miura Yuri、Tsumoto Hiroki、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
- Journal Title
  
  FEBS Lett.
  
  Volume: 591 Issue: 24 Pages: 4067-4073
- DOI
  10.1002/1873-3468.12914
- NAID
  120007134579
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01811, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-17H02179
[Journal Article] Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats.2015
- Author(s)
  Naoyuki Okita, Takuro Tsuchiya, Mayumi Fukushima, Kaho Itakura, Keiko Yuguchi, Takumi Narita, Yukari Hashizume, Yuka Sudo, Takuya Chiba, Isao Shimokawa, Yoshikazu Higami,
- Journal Title
  
  EXPERIMENTAL GERONTOLOGY
  
  Volume: 63 Pages: 59-66
- DOI
  10.1016/j.exger.2015.01.043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860200, KAKENHI-PROJECT-25860759, KAKENHI-PROJECT-25282027
[Journal Article] Poly(ADP-ribose) Polymerase Inhibitor (PJ34) Reduces Pulmonary Ischemia-Reperfusion Injury in Rats2014
- Author(s)
  Hatachi G, Tsuchiya T, Miyazaki T, Matsumoto K, Yamasaki N, Okita N, Nagashima A, Higami Y, Nagayasu T
- Journal Title
  
  Transplantation
  
  Volume: 98 Issue: 6 Pages: 618-624
- DOI
  10.1097/tp.0000000000000305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860759
[Journal Article] Inhibitory effect of p53 in mitochondrial content and function during adipogenesis.2014
- Author(s)
  Okita N, Ishikawa N, Oku M, Nagai W, Suzuki Y, Mizunoe Y, Matsushima S, Mikami K, Okado H, Sasaki T, Higami Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 446 Issue: 1 Pages: 91-97
- DOI
  10.1016/j.bbrc.2014.02.059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860759
[Journal Article] CHK1 cleavage in programmed cell death is regulated by caspase and non-caspase family proteases2013
- Author(s)
  Okita N (Corresponding author), Yoshimura M, Watanabe K, Minato S, Kudo Y, Higami Y, Tanuma S
- Journal Title
  
  Biochimica et Biophysica Acta-General Subjects
  
  Volume: 1830 Pages: 2204-2213
- Data Source
  KAKENHI-PROJECT-23790201
[Journal Article] カロリー制限による白色脂肪組織を中心とした脂質代謝の活性化2012
- Author(s)
  藤井波木、沖田直之、樋上賀一
- Journal Title
  
  基礎老化研究
  
  Volume: 36巻3号 Pages: 31-38
- NAID
  10031121034
- Data Source
  KAKENHI-PROJECT-23790201
[Journal Article] DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by intramolecular mechanism2012
- Author(s)
  Okita N (Corresponding author), Minato S, Ohmi E, Tanuma S, Higami Y
- Journal Title
  
  FEBS Letters
  
  Volume: 586 Pages: 3974-3979
- Data Source
  KAKENHI-PROJECT-23790201
[Journal Article] Revesible induction of PARP1 degradation by p53 inducible cis-imidazoline compounds2012
- Author(s)
  Nagai W, Okita N (Co-1st author and corresponding author), Matsumoto H, Okado H, Oku M, Higami Y
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 421 Pages: 21-25
- Data Source
  KAKENHI-PROJECT-23790201
[Journal Article] Autophagosomes accumulate in differentiated and hypertrophic adipocytes in a p53-independent manner2012
- Author(s)
  Mikami K, Okita N, Tokunaga Y, Ichikawa T, Okazaki T, Takemoto K, Nagai W, Matsushima S, Higami Y
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 427 Pages: 758-763
- Data Source
  KAKENHI-PROJECT-23790201
[Journal Article] Reversible induction of PARP1 degradation by p53-inducible cis-imidazoline compounds.2012
- Author(s)
  Nagai W, Okita N, Matsumoto H, Okado H, Oku M, Higami Y
- Journal Title
  
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  
  Volume: 421(1) Issue: 1 Pages: 15-19
- DOI
  10.1016/j.bbrc.2012.03.091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790201
[Journal Article] Differential Responses of White Adipose Tissue and Brown Adipose Tissue to Caloric Restriction in Rats2012
- Author(s)
  Okita N, Hayashida Y, Kojima Y, Fukushima M, Yuguchi K, Mikami K, Yamauchi A, Watanabe K, Noguchi M, Nakamura M, Toda T, Higami Y
- Journal Title
  
  Mechanisms of Ageing and Development
  
  Volume: 133 Pages: 255-266
- Data Source
  KAKENHI-PROJECT-23790201
[Journal Article] DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism.2012
- Author(s)
  Okita N, Minato S, Ohmi E, Tanuma S, Higami Y.
- Journal Title
  
  FEBS Lett.
  
  Volume: 586 Issue: 22 Pages: 3974-3979
- DOI
  10.1016/j.febslet.2012.09.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590107, KAKENHI-PROJECT-23300365, KAKENHI-PROJECT-23790201
[Journal Article] Caloric restriction-associated remodeling of rat white adipose tissue: Effects on the growth hormone/insulin-like growth factor-1 axis2012
- Author(s)
  Chujo Y, Fujii N, Okita N (Co-1st author), Konishi T, Narita T, Yamada A, Haruyama Y, Tashiro K, Chiba T, Shimokawa I, Higami Y
- Journal Title
  
  sterol regulatory element binding protein-1 and macrophage infiltration
- Data Source
  KAKENHI-PROJECT-23790201
[Journal Article] An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts2011
- Author(s)
  Matsushima S, Okita N, Oku M, Nagai W, Kobayashi M, Higami Y
- Journal Title
  
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  
  Volume: 407(3) Issue: 3 Pages: 557-561
- DOI
  10.1016/j.bbrc.2011.03.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790201
[Journal Article] Bacterial production of recombinant human poly(ADP-ribose) glycohydrolase2011
- Author(s)
  Okita N (Corresponding author), Ohta R, Ashizawa D, Yamada Y, Abe H, Abe T, Tanuma S
- Journal Title
  
  Protein Expression and Purification
  
  Volume: 75 Pages: 230-235
- Data Source
  KAKENHI-PROJECT-23790201
[Journal Article] An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts2011
- Author(s)
  Matsushima S, Okita N (Co-1st author and corresponding author), Oku M, Nagai W, Kobayashi M, Higami Y
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 407 Pages: 557-61
- Data Source
  KAKENHI-PROJECT-23790201
[Patent] Method of treating ischemia/reperfusion2012
- Inventor(s)
  樋上賀一、沖田直之、松島慎吾
- Industrial Property Rights Holder
  東京理科大学TLO
- Filing Date
  2012
- Overseas
- Data Source
  KAKENHI-PROJECT-23790201
[Patent] METHOD OF TREATING ISCHEMIA/ REPERFUSION INJURY2012
- Inventor(s)
  樋上賀一、沖田直之、松島慎吾
- Industrial Property Rights Holder
  東京理科大学
- Filing Date
  2012-01-27
- Overseas
- Data Source
  KAKENHI-PROJECT-23790201
[Presentation] Western blottingのプロトコール改変による低分子量ペプチドの分離検出-糖尿病関連ペプチドホルモンを実施例として-2019
- Author(s)
  沖田直之、樋上賀一、深井文雄、小林正樹、御手洗光来、関谷剛男、佐々木敬
- Organizer
  第60回日本生化学会中四国支部大会
- Data Source
  KAKENHI-PROJECT-18K11119
[Presentation] 皮下脂肪と内臓脂肪におけるカロリー制限への応答の相違2017
- Author(s)
  成田匠、小林正樹、須藤結香、沖田直之、樋上賀一
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Novel regulatory mechanism of PARP1 protein mediated by MDM2 inhibitors.2016
- Author(s)
  Okita N., Matsushima S., Nagai W., Higami Y.
- Organizer
  The International Postgraduate Conference 2016
- Place of Presentation
  Noda, Chiba, Japan
- Year and Date
  2016-02-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25860759
[Presentation] 新たなカロリー制限の分子メカニズム　～脂肪代謝と脂肪組織のリモデリング～2015
- Author(s)
  成田匠、沖田直之、須藤結香、樋上賀一
- Organizer
  老化促進モデルマウス（SAM)研究協議会・第30回研究発表会
- Place of Presentation
  岐阜市岐阜大学サテライトキャンパス
- Year and Date
  2015-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26670193
[Presentation] Chk1 cleavage by both CASP and non-CASP family proteases during programmed cell death2012
- Author(s)
  Okita N, Yoshimura M, Watanabe K, Minato S, Tanuma S, Higami Y
- Organizer
  The 1st International Postgraduate Conference 2012 at University of technology MARA
- Place of Presentation
  Malaysia
- Data Source
  KAKENHI-PROJECT-23790201
[Presentation] Chk1 cleavage by both CASP and non-CASP family proteases during programmed cell death2012
- Author(s)
  Okita N., et al.
- Organizer
  The 1st International Postgraduate Conference 2012
- Place of Presentation
  Shah alam, Malaysia
- Data Source
  KAKENHI-PROJECT-23790201
[Presentation] Parp1タンパク新規制御機構～虚血再灌流障害治療法への応用に向けて～2011
- Author(s)
  沖田直之
- Organizer
  第10回国際バイオエクスポ
- Place of Presentation
  東京ビッグサイト（東京）
- Data Source
  KAKENHI-PROJECT-23790201
[Presentation] PARP1 タンパク新規制御機構～虚血再灌流障害治療法への応用に向けて～2011
- Author(s)
  沖田直之、松島慎吾、奥美紗子、永井恒、小林正樹、樋上賀一
- Organizer
  第10回国際バイオ EXPO
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23790201
[Presentation] 細胞周期制御因子 CHK1 キナーゼによる細胞運命の制御2011
- Author(s)
  沖田直之
- Organizer
  日本薬学会関東支部大会若手シンポジウム
- Data Source
  KAKENHI-PROJECT-23790201
[Presentation] カロリー制限時の白色脂肪組織におけるSrebp-1 支配的遺伝子発現変動の網羅的解析2009
- Author(s)
  仲條良和、沖田直之、伊藤麻希子、鈴木智典、宮崎智、樋上賀一
- Organizer
  第32回日本基礎老化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590396

1. HIGAMI Yoshikazu (90253640)

# of Collaborated Projects: 7 results

# of Collaborated Products: 16 results
2. 小林正樹 (30795612)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. SHIMOKAWA Isao (70187475)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. CHIBA Takuya (40336152)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 中川嘉 (80361351)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. SUDO Yuka (70646695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 柴田淳史 (30707633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 野口満 (00325648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 三浦ゆり (00216574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 近藤洋介 (30778204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 小松雅明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 佐々木敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 田沼靖一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okita Naoyuki 沖田 直之

OKITA Naoyuki 沖田 直之

Research Projects

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Co-Researchers

膵β細胞における機能疲弊と分化転換の可塑性・可逆性が織りなす糖尿病病態の多様性Principal Investigator

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Reguratory mechanisms of lifespan by altered energy metabolism via splicing control

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Molecular basis of transdifferentiation mechanism in type 2 diabetes mellitus ~for establishment of personalized therapy for type 2 diabetes~Principal Investigator

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Dysregulation of lysosome/mitochondrial interaction in obese adipose tissue

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Comprehensive mitochondrial quality control and its collapse in metabolic diseases

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Challenge for diabetes therapy based on understanding of stress signals in pancreatic islet nichePrincipal Investigator

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Functional Analysis of a Novel Obesity-associated E3 Ubiquitin Ligase WWP1

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Development of therapeutic agents for ischemia/reperfusion injury utilizing a novel regulatory mechanism of Parp1Principal Investigator

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Suppressed cellular damage and inflammation, and altered metabolism by caloric restriction via SREBP1/LXR

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[Book] AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging (chapter Autophagy in adipose tissue )2016

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[Book] Section 15. Other determinants of sensitivity, PARP Inhibitors for Cancer Therapy (Edited by Curtin N, Sharma R)2015

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[Journal Article] Bioactive TNIIIA2 Sequence in Tenascin-C Is Responsible for Macrophage Foam Cell Transformation; Potential of FNIII14 Peptide Derived from Fibronectin in Suppression of Atherosclerotic Plaque Formation2024

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[Journal Article] Heat shock‐induced heme oxygenase‐1 expression in a mouse hepatoma cell line is dependent on <scp>HSF1</scp> and modified by <scp>NRF2</scp> and <scp>BACH1</scp>2022

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[Journal Article] Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids2022

Okita Naoyuki 沖田直之

OKITA Naoyuki 沖田直之