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Okita Naoyuki  沖田 直之

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OKITA Naoyuki  沖田 直之

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Researcher Number 60453841
Other IDs
Affiliation (Current) 2025: 山陽小野田市立山口東京理科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help 2018 – 2023: 山陽小野田市立山口東京理科大学, 薬学部, 講師
2017: 公益財団法人佐々木研究所, 附属研究所, 部長(移行)
2015: 公益財団法人佐々木研究所, 附属佐々木研究所, 研究員
2014 – 2015: 公益財団法人佐々木研究所, 付属研究所, 研究員
2013 – 2015: 公益財団法人佐々木研究所, その他部局等, 研究員
2011 – 2013: 東京理科大学, 薬学部, 助教
2008: 東京理科大学, 薬学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 59040:Nutrition science and health science-related / Metabolomics / Medical pharmacy
Except Principal Investigator
Experimental pathology / Basic Section 59040:Nutrition science and health science-related / Applied health science
Keywords
Principal Investigator
2型糖尿病 / 膵島 / 機能疲弊 / 分化転換 / 膵島障害 / 膵島傷害 / 膵島ニッチ / ストレス応答 / Nutlin-3a / Parp1 … More / プロテアソーム / p53 / 虚血再灌流障害 / Caylin2 / Nutlin3a / PARP1 … More
Except Principal Investigator
カロリー制限 / ミトコンドリア / 脂肪組織 / ミトファジー / ミトコンドリアシグナルペプチダーゼ / Mipep / 肥満症 / 脂肪細胞 / ノックアウトマウス / 寿命 / 老化 / リポジストロフィー / エネルギー代謝 / MIPEP / リポディストロフィー / スプライシング制御 / 脂質代謝 / スプライシング / 体内時計 / リソソーム / PARIS / ミトコンドリア生合成 / PINK1/PARKIN / SIRT3 / ミトコンドリア品質管理 / ミトコンドリア病 / ミトコンドリアシグナルペプチターゼ / ミトコンドリアの品質管理 / Srebp-1c / 白色脂肪組織(WAT) / カロリーの制限(CR) / Sirt3 / シグナルペプチダーゼ / 品質管理 / ユビキチンリガーゼ / WWP1 / p53 / 炎症 / 細胞傷害 / LXR / SREBPI / SREBP1 Less
  • Research Projects

    (9 results)
  • Research Products

    (49 results)
  • Co-Researchers

    (13 People)
  •  膵β細胞における機能疲弊と分化転換の可塑性・可逆性が織りなす糖尿病病態の多様性Principal Investigator

    • Principal Investigator
      沖田 直之
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Tokyo University of Science, Yamaguchi
  •  Reguratory mechanisms of lifespan by altered energy metabolism via splicing control

    • Principal Investigator
      Higami Yoshikazu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Tokyo University of Science
  •  Molecular basis of transdifferentiation mechanism in type 2 diabetes mellitus ~for establishment of personalized therapy for type 2 diabetes~Principal Investigator

    • Principal Investigator
      OKITA Naoyuki
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Tokyo University of Science, Yamaguchi
  •  Dysregulation of lysosome/mitochondrial interaction in obese adipose tissue

    • Principal Investigator
      Higami Yoshikazu
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied health science
    • Research Institution
      Tokyo University of Science
  •  Comprehensive mitochondrial quality control and its collapse in metabolic diseases

    • Principal Investigator
      Higami Yoshikazu
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo University of Science
  •  Challenge for diabetes therapy based on understanding of stress signals in pancreatic islet nichePrincipal Investigator

    • Principal Investigator
      Okita Naoyuki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      Sasaki Foundation
  •  Functional Analysis of a Novel Obesity-associated E3 Ubiquitin Ligase WWP1

    • Principal Investigator
      HIGAMI Yoshikazu
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo University of Science
  •  Development of therapeutic agents for ischemia/reperfusion injury utilizing a novel regulatory mechanism of Parp1Principal Investigator

    • Principal Investigator
      OKITA Naoyuki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Tokyo University of Science
  •  Suppressed cellular damage and inflammation, and altered metabolism by caloric restriction via SREBP1/LXR

    • Principal Investigator
      HIGAMI Yoshikazu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo University of Science

All 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009

All Journal Article Presentation Book Patent

  • [Book] AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging (chapter Autophagy in adipose tissue )2016

    • Author(s)
      Mizunoe Y, Sudo Y, Okita N, Higami Y
    • Total Pages
      23
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-25860759
  • [Book] Section 15. Other determinants of sensitivity, PARP Inhibitors for Cancer Therapy (Edited by Curtin N, Sharma R)2015

    • Author(s)
      Okita N, Shibata A
    • Total Pages
      593
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-25860759
  • [Journal Article] Bioactive TNIIIA2 Sequence in Tenascin-C Is Responsible for Macrophage Foam Cell Transformation; Potential of FNIII14 Peptide Derived from Fibronectin in Suppression of Atherosclerotic Plaque Formation2024

    • Author(s)
      Iyoda Takuya、Ohishi Asayo、Wang Yunong、Yokoyama Miyabi-Shara、Kazama Mika、Okita Naoyuki、Inouye Sachiye、Nakagawa Yoshimi、Shimano Hitoshi、Fukai Fumio
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 3 Pages: 1825-1825

    • DOI

      10.3390/ijms25031825

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K10894, KAKENHI-PROJECT-22H00474
  • [Journal Article] Heat shock‐induced heme oxygenase‐1 expression in a mouse hepatoma cell line is dependent on <scp>HSF1</scp> and modified by <scp>NRF2</scp> and <scp>BACH1</scp>2022

    • Author(s)
      Inouye Sachiye、Kubo Takanori、Miyamoto Takafumi、Iyoda Takuya、Okita Naoyuki、Akagi Reiko
    • Journal Title

      Genes to Cells

      Volume: 27 Issue: 12 Pages: 719-730

    • DOI

      10.1111/gtc.12986

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-21K19064, KAKENHI-PROJECT-23K23562, KAKENHI-PROJECT-23K24297
  • [Journal Article] Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids2022

    • Author(s)
      Tagawa Ryoma、Kobayashi Masaki、Sakurai Misako、Yoshida Maho、Kaneko Hiroki、Mizunoe Yuhei、Nozaki Yuka、Okita Naoyuki、Sudo Yuka、Higami Yoshikazu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 3 Pages: 1793-1793

    • DOI

      10.3390/ijms23031793

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-22K17814, KAKENHI-PROJECT-20K19686
  • [Journal Article] Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle2021

    • Author(s)
      Yuhei Mizunoe, Masaki Kobayashi, Hiroki Saito, Akifumi Goto, Ryota Migitaka, Kumi Miura, Naoyuki Okita, Yuka Sudo, Ryoma Tagawa, Miki Yoshida, Ai Umemori, Yoshimi Nakagawa, Hitoshi Shimano, Yoshikazu Higami
    • Journal Title

      Experimental gerontology

      Volume: 154 Pages: 111519-111519

    • DOI

      10.1016/j.exger.2021.111519

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19J00407, KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
  • [Journal Article] Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes2020

    • Author(s)
      Kobayashi Masaki、Yasukawa Hiromine、Arikawa Tomoya、Deguchi Yusuke、Mizushima Natsumi、Sakurai Misako、Onishi Shoichi、Tagawa Ryoma、Sudo Yuka、Okita Naoyuki、Higashi Kyohei、Higami Yoshikazu
    • Journal Title

      FEBS Open Bio

      Volume: 11 Issue: 1 Pages: 185-194

    • DOI

      10.1002/2211-5463.13055

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
  • [Journal Article] WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism2020

    • Author(s)
      Hoshino Shunsuke、Kobayashi Masaki、Tagawa Ryoma、Konno Ryutaro、Abe Takuro、Furuya Kazuhiro、Miura Kumi、Wakasawa Hiroki、Okita Naoyuki、Sudo Yuka、Mizunoe Yuhei、Nakagawa Yoshimi、Nakamura Takeshi、Kawabe Hiroshi、Higami Yoshikazu
    • Journal Title

      FEBS Open Bio

      Volume: 10 Issue: 3 Pages: 306-315

    • DOI

      10.1002/2211-5463.12795

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
  • [Journal Article] Is PARP-1 Inhibitor (Nutlin3a) Effective on Hepatic Ischemia-Reperfusion Injury?2020

    • Author(s)
      Kawahara Daisuke、Yamanouchi Kosho、Okita Naoyuki、Higami Yoshikazu、Inoue Yusuke、Ito Shinichiro、Hidaka Masaaki、Kanetaka Kengo、Fujita Fumihiko、Eguchi Susumu
    • Journal Title

      Surgery, Gastroenterology and Oncology

      Volume: 25 Issue: 4 Pages: 189-189

    • DOI

      10.21614/sgo-25-4-189

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K11119
  • [Journal Article] Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes2020

    • Author(s)
      Mizunoe Yuhei、Kobayashi Masaki、Hoshino Shunsuke、Tagawa Ryoma、Itagawa Rei、Hoshino Ayana、Okita Naoyuki、Sudo Yuka、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 634-634

    • DOI

      10.1038/s41598-020-57428-6

    • NAID

      120007165462

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-18K17953, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-17H02179
  • [Journal Article] Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line2020

    • Author(s)
      Kobayashi Masaki、Ishizaki Yuka、Owaki Mika、Matsumoto Yoko、Kakiyama Yuri、Hoshino Shunsuke、Tagawa Ryoma、Sudo Yuka、Okita Naoyuki、Akimoto Kazunori、Higami Yoshikazu
    • Journal Title

      Oncotarget

      Volume: 11 Issue: 18 Pages: 1653-1665

    • DOI

      10.18632/oncotarget.27581

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20K07207, KAKENHI-PROJECT-20K19686
  • [Journal Article] Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue.2019

    • Author(s)
      Namiki Fujii, Seira Uta, Masaki Kobayashi, Tsugumichi Sato, Naoyuki Okita, Yoshikazu Higami
    • Journal Title

      Experimental gerontology

      Volume: 118 Pages: 55-64

    • DOI

      10.1016/j.exger.2019.01.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
  • [Journal Article] Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes2019

    • Author(s)
      Kobayashi Masaki、Hoshino Shunsuke、Abe Takuro、Okita Naoyuki、Tagawa Ryoma、Nagai Wataru、Konno Ryutaro、Suzuki Yuki、Furuya Kazuhiro、Ishikawa Natsumi、Okado Hitoshi、Oku Misako、Iwamoto Machiko、Miura Yuri、Sudo Yuka、Higami Yoshikazu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 508 Issue: 1 Pages: 117-122

    • DOI

      10.1016/j.bbrc.2018.11.127

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-17H02179
  • [Journal Article] ウエスタンブロッティングの改変によるペプチドホルモンの分離検出2018

    • Author(s)
      沖田直之
    • Journal Title

      理大科学フォーラム

      Volume: 35 Pages: 40-45

    • NAID

      40021694698

    • Data Source
      KAKENHI-PROJECT-18K11119
  • [Journal Article] Differential response to caloric restriction of retroperitoneal, epididymal, and subcutaneous adipose tissue depots in rats2018

    • Author(s)
      Narita Takumi、Kobayashi Masaki、Itakura Kaho、Itagawa Rei、Kabaya Riho、Sudo Yuka、Okita Naoyuki、Higami Yoshikazu
    • Journal Title

      Exp Gerontol

      Volume: 104 Pages: 127-137

    • DOI

      10.1016/j.exger.2018.01.016

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H02179
  • [Journal Article] Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways2018

    • Author(s)
      Mizunoe Yuhei、Kobayashi Masaki、Sudo Yuka、Watanabe Shukoh、Yasukawa Hiromine、Natori Daiki、Hoshino Ayana、Negishi Arisa、Okita Naoyuki、Komatsu Masaaki、Higami Yoshikazu
    • Journal Title

      Redox Biol.

      Volume: 15 Pages: 115-124

    • DOI

      10.1016/j.redox.2017.09.007

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-17H02179
  • [Journal Article] Taurine is an amino acid with the ability to activate autophagy in adipocytes.2018

    • Author(s)
      Kaneko H, Kobayashi M, Mizunoe Y, Yoshida M, Yasukawa H, Hoshino S, Itagawa R, Furuichi T, Okita N, Sudo Y, Imae M, Higami Y
    • Journal Title

      Amino Acids

      Volume: 50 Issue: 5 Pages: 527-535

    • DOI

      10.1007/s00726-018-2550-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H02179
  • [Journal Article] Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia2018

    • Author(s)
      Sudo Yuka、Otsuka Hiroki、Miyakawa Ryota、Goto Akifumi、Kashiwase Yohei、Terawaki Kiyoshi、Miyano Kanako、Hirao Yuto、Taki Kanari、Tagawa Ryoma、Kobayashi Masaki、Okita Naoyuki、Uezono Yasuhito、Higami Yoshikazu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 12 Pages: 3852-3852

    • DOI

      10.3390/ijms19123852

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
  • [Journal Article] Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice2017

    • Author(s)
      Mizunoe Yuhei、Sudo Yuka、Okita Naoyuki、Hiraoka Hidenori、Mikami Kentaro、Narahara Tomohiro、Negishi Arisa、Yoshida Miki、Higashibata Rikako、Watanabe Shukoh、Kaneko Hiroki、Natori Daiki、Furuichi Takuma、Yasukawa Hiromine、Kobayashi Masaki、Higami Yoshikazu
    • Journal Title

      Autophagy

      Volume: 13 Issue: 4 Pages: 642-653

    • DOI

      10.1080/15548627.2016.1274850

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H02179
  • [Journal Article] Modified Western blotting for insulin and other diabetes-associated peptide hormones.2017

    • Author(s)
      Okita N, Higami Y, Fukai F, Kobayashi M, Mitarai M, Sekiya T, Sasaki T.
    • Journal Title

      Sci Rep

      Volume: 7:6949 Issue: 1 Pages: 1-11

    • DOI

      10.1038/s41598-017-04456-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461346, KAKENHI-PROJECT-17H02179
  • [Journal Article] Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction2017

    • Author(s)
      Fujii Namiki、Narita Takumi、Okita Naoyuki、Kobayashi Masaki、Furuta Yurika、Chujo Yoshikazu、Sakai Masahiro、Yamada Atsushi、Takeda Kanae、Konishi Tomokazu、Sudo Yuka、Shimokawa Isao、Higami Yoshikazu
    • Journal Title

      Aging Cell

      Volume: 16 Issue: 3 Pages: 508-517

    • DOI

      10.1111/acel.12576

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H02179
  • [Journal Article] Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction2017

    • Author(s)
      Kobayashi Masaki、Takeda Kanae、Narita Takumi、Nagai Keita、Okita Naoyuki、Sudo Yuka、Miura Yuri、Tsumoto Hiroki、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
    • Journal Title

      FEBS Lett.

      Volume: 591 Issue: 24 Pages: 4067-4073

    • DOI

      10.1002/1873-3468.12914

    • NAID

      120007134579

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K01811, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-17H02179
  • [Journal Article] Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats.2015

    • Author(s)
      Naoyuki Okita, Takuro Tsuchiya, Mayumi Fukushima, Kaho Itakura, Keiko Yuguchi, Takumi Narita, Yukari Hashizume, Yuka Sudo, Takuya Chiba, Isao Shimokawa, Yoshikazu Higami,
    • Journal Title

      EXPERIMENTAL GERONTOLOGY

      Volume: 63 Pages: 59-66

    • DOI

      10.1016/j.exger.2015.01.043

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25860200, KAKENHI-PROJECT-25860759, KAKENHI-PROJECT-25282027
  • [Journal Article] Poly(ADP-ribose) Polymerase Inhibitor (PJ34) Reduces Pulmonary Ischemia-Reperfusion Injury in Rats2014

    • Author(s)
      Hatachi G, Tsuchiya T, Miyazaki T, Matsumoto K, Yamasaki N, Okita N, Nagashima A, Higami Y, Nagayasu T
    • Journal Title

      Transplantation

      Volume: 98 Issue: 6 Pages: 618-624

    • DOI

      10.1097/tp.0000000000000305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860759
  • [Journal Article] Inhibitory effect of p53 in mitochondrial content and function during adipogenesis.2014

    • Author(s)
      Okita N, Ishikawa N, Oku M, Nagai W, Suzuki Y, Mizunoe Y, Matsushima S, Mikami K, Okado H, Sasaki T, Higami Y.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 446 Issue: 1 Pages: 91-97

    • DOI

      10.1016/j.bbrc.2014.02.059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25860759
  • [Journal Article] CHK1 cleavage in programmed cell death is regulated by caspase and non-caspase family proteases2013

    • Author(s)
      Okita N (Corresponding author), Yoshimura M, Watanabe K, Minato S, Kudo Y, Higami Y, Tanuma S
    • Journal Title

      Biochimica et Biophysica Acta-General Subjects

      Volume: 1830 Pages: 2204-2213

    • Data Source
      KAKENHI-PROJECT-23790201
  • [Journal Article] カロリー制限による白色脂肪組織を中心とした脂質代謝の活性化2012

    • Author(s)
      藤井波木、沖田直之、樋上賀一
    • Journal Title

      基礎老化研究

      Volume: 36巻3号 Pages: 31-38

    • NAID

      10031121034

    • Data Source
      KAKENHI-PROJECT-23790201
  • [Journal Article] DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by intramolecular mechanism2012

    • Author(s)
      Okita N (Corresponding author), Minato S, Ohmi E, Tanuma S, Higami Y
    • Journal Title

      FEBS Letters

      Volume: 586 Pages: 3974-3979

    • Data Source
      KAKENHI-PROJECT-23790201
  • [Journal Article] Revesible induction of PARP1 degradation by p53 inducible cis-imidazoline compounds2012

    • Author(s)
      Nagai W, Okita N (Co-1st author and corresponding author), Matsumoto H, Okado H, Oku M, Higami Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 421 Pages: 21-25

    • Data Source
      KAKENHI-PROJECT-23790201
  • [Journal Article] Autophagosomes accumulate in differentiated and hypertrophic adipocytes in a p53-independent manner2012

    • Author(s)
      Mikami K, Okita N, Tokunaga Y, Ichikawa T, Okazaki T, Takemoto K, Nagai W, Matsushima S, Higami Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 427 Pages: 758-763

    • Data Source
      KAKENHI-PROJECT-23790201
  • [Journal Article] Reversible induction of PARP1 degradation by p53-inducible cis-imidazoline compounds.2012

    • Author(s)
      Nagai W, Okita N, Matsumoto H, Okado H, Oku M, Higami Y
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

      Volume: 421(1) Issue: 1 Pages: 15-19

    • DOI

      10.1016/j.bbrc.2012.03.091

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790201
  • [Journal Article] Differential Responses of White Adipose Tissue and Brown Adipose Tissue to Caloric Restriction in Rats2012

    • Author(s)
      Okita N, Hayashida Y, Kojima Y, Fukushima M, Yuguchi K, Mikami K, Yamauchi A, Watanabe K, Noguchi M, Nakamura M, Toda T, Higami Y
    • Journal Title

      Mechanisms of Ageing and Development

      Volume: 133 Pages: 255-266

    • Data Source
      KAKENHI-PROJECT-23790201
  • [Journal Article] DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism.2012

    • Author(s)
      Okita N, Minato S, Ohmi E, Tanuma S, Higami Y.
    • Journal Title

      FEBS Lett.

      Volume: 586 Issue: 22 Pages: 3974-3979

    • DOI

      10.1016/j.febslet.2012.09.048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590107, KAKENHI-PROJECT-23300365, KAKENHI-PROJECT-23790201
  • [Journal Article] Caloric restriction-associated remodeling of rat white adipose tissue: Effects on the growth hormone/insulin-like growth factor-1 axis2012

    • Author(s)
      Chujo Y, Fujii N, Okita N (Co-1st author), Konishi T, Narita T, Yamada A, Haruyama Y, Tashiro K, Chiba T, Shimokawa I, Higami Y
    • Journal Title

      sterol regulatory element binding protein-1 and macrophage infiltration

    • Data Source
      KAKENHI-PROJECT-23790201
  • [Journal Article] An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts2011

    • Author(s)
      Matsushima S, Okita N, Oku M, Nagai W, Kobayashi M, Higami Y
    • Journal Title

      BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

      Volume: 407(3) Issue: 3 Pages: 557-561

    • DOI

      10.1016/j.bbrc.2011.03.061

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790201
  • [Journal Article] Bacterial production of recombinant human poly(ADP-ribose) glycohydrolase2011

    • Author(s)
      Okita N (Corresponding author), Ohta R, Ashizawa D, Yamada Y, Abe H, Abe T, Tanuma S
    • Journal Title

      Protein Expression and Purification

      Volume: 75 Pages: 230-235

    • Data Source
      KAKENHI-PROJECT-23790201
  • [Journal Article] An Mdm2 antagonist, Nutlin-3a, induces p53-dependent and proteasome-mediated poly(ADP-ribose) polymerase1 degradation in mouse fibroblasts2011

    • Author(s)
      Matsushima S, Okita N (Co-1st author and corresponding author), Oku M, Nagai W, Kobayashi M, Higami Y
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 407 Pages: 557-61

    • Data Source
      KAKENHI-PROJECT-23790201
  • [Patent] Method of treating ischemia/reperfusion2012

    • Inventor(s)
      樋上賀一、沖田直之、松島慎吾
    • Industrial Property Rights Holder
      東京理科大学TLO
    • Filing Date
      2012
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23790201
  • [Patent] METHOD OF TREATING ISCHEMIA/ REPERFUSION INJURY2012

    • Inventor(s)
      樋上賀一、沖田直之、松島慎吾
    • Industrial Property Rights Holder
      東京理科大学
    • Filing Date
      2012-01-27
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23790201
  • [Presentation] Western blottingのプロトコール改変による低分子量ペプチドの分離検出-糖尿病関連ペプチドホルモンを実施例として-2019

    • Author(s)
      沖田直之、樋上賀一、深井文雄、小林正樹、御手洗光来、関谷剛男、佐々木敬
    • Organizer
      第60回日本生化学会中四国支部大会
    • Data Source
      KAKENHI-PROJECT-18K11119
  • [Presentation] 皮下脂肪と内臓脂肪におけるカロリー制限への応答の相違2017

    • Author(s)
      成田匠、小林正樹、須藤結香、沖田直之、樋上賀一
    • Organizer
      第38回日本肥満学会
    • Data Source
      KAKENHI-PROJECT-17H02179
  • [Presentation] Novel regulatory mechanism of PARP1 protein mediated by MDM2 inhibitors.2016

    • Author(s)
      Okita N., Matsushima S., Nagai W., Higami Y.
    • Organizer
      The International Postgraduate Conference 2016
    • Place of Presentation
      Noda, Chiba, Japan
    • Year and Date
      2016-02-27
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25860759
  • [Presentation] 新たなカロリー制限の分子メカニズム ~脂肪代謝と脂肪組織のリモデリング~2015

    • Author(s)
      成田匠、沖田直之、須藤結香、樋上賀一
    • Organizer
      老化促進モデルマウス(SAM)研究協議会・第30回研究発表会
    • Place of Presentation
      岐阜市岐阜大学サテライトキャンパス
    • Year and Date
      2015-07-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670193
  • [Presentation] Chk1 cleavage by both CASP and non-CASP family proteases during programmed cell death2012

    • Author(s)
      Okita N, Yoshimura M, Watanabe K, Minato S, Tanuma S, Higami Y
    • Organizer
      The 1st International Postgraduate Conference 2012 at University of technology MARA
    • Place of Presentation
      Malaysia
    • Data Source
      KAKENHI-PROJECT-23790201
  • [Presentation] Chk1 cleavage by both CASP and non-CASP family proteases during programmed cell death2012

    • Author(s)
      Okita N., et al.
    • Organizer
      The 1st International Postgraduate Conference 2012
    • Place of Presentation
      Shah alam, Malaysia
    • Data Source
      KAKENHI-PROJECT-23790201
  • [Presentation] Parp1タンパク新規制御機構~虚血再灌流障害治療法への応用に向けて~2011

    • Author(s)
      沖田直之
    • Organizer
      第10回国際バイオエクスポ
    • Place of Presentation
      東京ビッグサイト(東京)
    • Data Source
      KAKENHI-PROJECT-23790201
  • [Presentation] PARP1 タンパク新規制御機構~虚血再灌流障害治療法への応用に向けて~2011

    • Author(s)
      沖田直之、松島慎吾、奥美紗子、永井恒、小林正樹、樋上賀一
    • Organizer
      第10回国際バイオ EXPO
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23790201
  • [Presentation] 細胞周期制御因子 CHK1 キナーゼによる細胞運命の制御2011

    • Author(s)
      沖田直之
    • Organizer
      日本薬学会関東支部大会 若手シンポジウム
    • Data Source
      KAKENHI-PROJECT-23790201
  • [Presentation] カロリー制限時の白色脂肪組織におけるSrebp-1 支配的遺伝子発現変動の網羅的解析2009

    • Author(s)
      仲條 良和、沖田 直之、伊藤 麻希子、鈴木 智典、宮崎 智、樋上 賀一
    • Organizer
      第32回日本基礎老化学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19590396
  • 1.  HIGAMI Yoshikazu (90253640)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 16 results
  • 2.  小林 正樹 (30795612)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 3.  SHIMOKAWA Isao (70187475)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  CHIBA Takuya (40336152)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  中川 嘉 (80361351)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  SUDO Yuka (70646695)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  柴田 淳史 (30707633)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  野口 満 (00325648)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  三浦 ゆり (00216574)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  近藤 洋介 (30778204)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  小松 雅明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  佐々木 敬
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  田沼 靖一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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