Koike Naoyoshi 小池直義

Researcher Number	60464913
Other IDs	https://orcid.org/0000-0003-1952-0252
Affiliation (based on the past Project Information) *help	2021 – 2022: 慶應義塾大学, 医学部(信濃町), 特任講師 2021: 慶應義塾大学, 医学部(信濃町), 講師 2018 – 2020: 慶應義塾大学, 医学部(信濃町), 助教
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related Except Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science
Keywords	Principal Investigator 放射線治療 / 心毒性 / 細胞骨格 / 放射線心毒性 / 放射線抵抗性 / 幹細胞 / 2-ニトロイミダゾール / がん幹細胞 / theranostics / 2－ニトロイミダゾール化合物 / 膠芽腫 / 低酸素 … More Except Principal Investigator … More グリオーマ / 膵癌 / 放射線増感剤 / 放射線生物学 / 放射線感受性 / 電子伝達系 / 放射線治療 / 実験動物 / 放射線性心毒性 / 放射線増感作用 / 悪性グリオーマ / 放射線 / 5-アミノレブリン酸 / ドラッグリポジショニング / 増感剤 / 放射線照射 / クロロキン / 膵臓癌 / オートファジー / 放射線抵抗性 / 5-ALA / 放射線増感 / 5-aminolevulinic acid / 放射線低線量照射 / 低線量照射 / 膠芽腫 / DNA損傷 / 細胞周期 / Glioma Less

実験動物モデルを用いた照射後心毒性解析と治療薬開発
- Principal Investigator
  
  深田淳一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Keio University
電子伝達系の阻害による放射線感受性増強に着目した新規膵がん治療の開発に関する研究
- Principal Investigator
  
  澤田将史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Keio University
光感受性物質による放射線増強効果を用いた悪性脳腫瘍に対する新規治療の開発
- Principal Investigator
  
  三島眞代
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Keio University
Pathological analysis and examination of cytoskeleton-targeted therapy for overcoming cardiotoxicity caused by radiationPrincipal Investigator
- Principal Investigator
  
  Naoyoshi Koike
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Keio University
ポルフィリン前駆体による悪性脳腫瘍に対する新規放射線増感治療の開発
- Principal Investigator
  
  川田哲也
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Keio University
Development of new radiation sensitization therapy by drug repositioning of chloroquine
- Principal Investigator
  
  SHIGEMATSU Naoyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Keio University
Identification and analysis of drugs for overcoming hypoxia in glioblastomaPrincipal Investigator
- Principal Investigator
  
  Koike Naoyoshi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Keio University
Minimally invasive cancer treatment strategy using hyper-radiosensitivity in low-dose repeat irradiation - a Glioblastoma study
- Principal Investigator
  
  Fukada Junichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Keio University

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Mean heart dose-based normal tissue complication probability model for pericardial effusion: a study in oesophageal cancer patients2021
- Author(s)
  Fukada Junichi、Fukata Kyohei、Koike Naoyoshi、Kota Ryuichi、Shigematsu Naoyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 18166-18166
- DOI
  10.1038/s41598-021-97605-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16801, KAKENHI-PROJECT-21K07606, KAKENHI-PROJECT-20K16708
[Journal Article] Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy.2020
- Author(s)
  Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, Nagano O.
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 1 Pages: 127-136
- DOI
  10.1111/cas.14224
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03583, KAKENHI-PROJECT-18J14396, KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-18K15602
[Journal Article] 2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche2020
- Author(s)
  Koike Naoyoshi、Kota Ryuichi、Naito Yoshiko、Hayakawa Noriyo、Matsuura Tomomi、Hishiki Takako、Onishi Nobuyuki、Fukada Junichi、Suematsu Makoto、Shigematsu Naoyuki、Saya Hideyuki、Sampetrean Oltea
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 450-462
- DOI
  10.1038/s42003-020-01165-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07671, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-20K16801, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07771
[Presentation] 神経膠腫術後照射における摘出腔シフトの影響2022
- Author(s)
  深田淳一、公田龍一、小池直義、茂松直之
- Organizer
  日本放射線腫瘍学会第34回学術大会
- Data Source
  KAKENHI-PROJECT-22K07673
[Presentation] 放射線治療前絶食の有無による胃の移動量定量解析2021
- Author(s)
  深田淳一, 公田龍一, 小池直義, 竹下諒, 茂松直之
- Organizer
  日本放射線腫瘍学会第34回学術大会
- Data Source
  KAKENHI-PROJECT-21K07606
[Presentation] 脳転移に対する定位照射直前のMRI再撮像の有用性2021
- Author(s)
  栗林徹, 深田淳一, 公田龍一, 小池直義, 舟越和人, 片山真
- Organizer
  第30回日本定位放射線治療学会
- Data Source
  KAKENHI-PROJECT-21K07606
[Presentation] Rhoキナーゼ阻害薬ファスジルは放射線による心弁膜線維化を改善する2020
- Author(s)
  小池直義, 深田淳一, 公田龍一, 茂松直之
- Organizer
  日本放射線腫瘍学会第33回学術大会
- Data Source
  KAKENHI-PROJECT-20K16801
[Presentation] 機械学習による胸部放射線照射後の予後予測因子と有害事象発症予測因子の探索2020
- Author(s)
  深田淳一、深田恭平、小池直義、公田龍一、茂松直之
- Organizer
  第58回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07771
[Presentation] 放射線照射後のマウス心臓の形態学的・病理学的検討2019
- Author(s)
  小池直義、深田淳一、公田龍一、伊藤章吾、湯浅慎介、茂松直之
- Organizer
  日本放射線腫瘍学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-18K07771
[Presentation] 低酸素ニッチ内癌幹細胞の放射線抵抗性の克服戦略2019
- Author(s)
  サンペトラオルテア、小池直義、佐谷秀行
- Organizer
  第78回日本癌学会学術大会
- Data Source
  KAKENHI-PROJECT-18K15602
[Presentation] 脳腫瘍幹細胞の低酸素応答と放射線抵抗性の克服2019
- Author(s)
  サンペトラオルテア、小池直義、佐谷秀行
- Organizer
  日本放射線腫瘍学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-18K15602
[Presentation] FDG-PETによる放射線療法効果判定と予後予測2019
- Author(s)
  元村祐介、深田淳一、中原理紀、小池直義、公田龍一、茂松直之
- Organizer
  日本放射線腫瘍学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-17K10492
[Presentation] マウス放射線肺臓炎モデルにおける病理学的検討2019
- Author(s)
  公田龍一、小池直義、深田淳一、茂松直之
- Organizer
  日本放射線腫瘍学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-18K07771

1. Fukada Junichi (50338159)

# of Collaborated Projects: 6 results

# of Collaborated Products: 7 results
2. 公田龍一 (00464834)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
3. 三島一彦 (00282640)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SHIGEMATSU Naoyuki (30178868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 川田哲也 (60234077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 三島眞代 (40897683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 澤田将史 (10824948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SAMPETREAN Oltea

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 永野修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koike Naoyoshi 小池 直義

Research Projects

Research Products

Co-Researchers

実験動物モデルを用いた照射後心毒性解析と治療薬開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

電子伝達系の阻害による放射線感受性増強に着目した新規膵がん治療の開発に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

光感受性物質による放射線増強効果を用いた悪性脳腫瘍に対する新規治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathological analysis and examination of cytoskeleton-targeted therapy for overcoming cardiotoxicity caused by radiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ポルフィリン前駆体による悪性脳腫瘍に対する新規放射線増感治療の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new radiation sensitization therapy by drug repositioning of chloroquine

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and analysis of drugs for overcoming hypoxia in glioblastomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Minimally invasive cancer treatment strategy using hyper-radiosensitivity in low-dose repeat irradiation - a Glioblastoma study

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mean heart dose-based normal tissue complication probability model for pericardial effusion: a study in oesophageal cancer patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 神経膠腫術後照射における摘出腔シフトの影響2022

Author(s)

Organizer

Data Source

[Presentation] 放射線治療前絶食の有無による胃の移動量定量解析2021

Author(s)

Organizer

Data Source

[Presentation] 脳転移に対する定位照射直前のMRI再撮像の有用性2021

Author(s)

Organizer

Data Source

[Presentation] Rhoキナーゼ阻害薬ファスジルは放射線による心弁膜線維化を改善する2020

Koike Naoyoshi 小池直義