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Ishikawa Fumihiro  石川 文博

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ISHIKAWA Fumihiro  石川 文博

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Researcher Number 60515667
Other IDs
Affiliation (Current) 2025: 昭和医科大学, 大学共同利用機関等の部局等, 准教授
Affiliation (based on the past Project Information) *help 2023: 昭和大学, 大学共同利用機関等の部局等, 准教授
2020 – 2022: 昭和大学, 大学共同利用機関等の部局等, 講師
2019 – 2021: 昭和大学, 薬学部, 講師
2009 – 2018: 昭和大学, 薬学部, 助教
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related
Except Principal Investigator
Pathological medical chemistry / Basic Section 49010:Pathological biochemistry-related / Basic Section 48030:Pharmacology-related / Cell biology
Keywords
Principal Investigator
ミトコンドリア / アノイキス / 活性酸素種 / 転移 / レドックス / がん転移 / 足場非依存性増殖 / DICD / 代謝 / 足場依存的生存 / がん / エネルギー代謝 / 癌 … More
Except Principal Investigator
… More ミトコンドリア / MMP9 / 活性酸素 / HMGA2 / Integrin β4 / 転移抑制 / 細胞接着 / Rac1 / integrin beta4 / 代謝ストレス応答 / 臓器横断的癌治療薬 / ミトコンドリアストレス応答機構 / 呼吸鎖 / AMPK / ミトコンドリアストレス応答 / p21cip1 / 電子伝達系 / ミトコンドリア電子伝達系 / エネルギー代謝 / NAD+ / サイクリン依存性キナーゼ阻害因子p21Cip1 / ミトコンドリア呼吸鎖 / NOX4 / MMP-9 / NADPH oxidase 4 / 活性酸素種 / E2F1 / ミトコンドリア呼吸鎖活性 / 肝細胞がん / ミトコンドリアDNA変異 / ミトコンドリアDNA / 足場非依存性増殖能 / HIC-5 / がん転移抑制 / 足場非依存性増殖 / プロテインキチーゼC / チオレドキシン / 膜電位 / TGFβ / CHOP-10 / CREB Less
  • Research Projects

    (10 results)
  • Research Products

    (43 results)
  • Co-Researchers

    (3 People)
  •  転移抑制を目指したRac1によるintegrin β4の分解抑制機構の解明

    • Principal Investigator
      森 一憲
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Showa University
  •  Respiratory chain activity as a target of tumor-agnostic therapy in highly glycolytic/low respiratory tumors

    • Principal Investigator
      柴沼 質子
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48030:Pharmacology-related
    • Research Institution
      Showa University
  •  Impact of mitochondrial complex I activity on cancer cell proliferation: importance of NAD+ levels

    • Principal Investigator
      Kazunori Mori
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Showa University
  •  SUZ12 supresses anoikis by alleviating oxidative stress in cancer cellsPrincipal Investigator

    • Principal Investigator
      Ishikawa Fumihiro
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Showa University
  •  A mitochondrial ROS pathway controls matrix metalloproteinase 9 levels and invasive properties in RAS-activated cancer cells

    • Principal Investigator
      Mori Kazunori
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Showa University
  •  Significance of mitochondrial DNA mutations in cancer cells: induction of HMGA2 in response to DNA damage

    • Principal Investigator
      Shibanuma Motoko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Showa University
  •  The mechanisms underlying repression of glycolysis by detachment and its significance in detachment-induced cell deathPrincipal Investigator

    • Principal Investigator
      ISHIKAWA FUMIHIRO
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Showa University
  •  Suppressive role of the adaptor protein Hic-5 in anchorage-independent cell growth

    • Principal Investigator
      KAZUNORI Mori
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Showa University
  •  Regulation of anoikis by mitochondrial activity and its ablation duringoncogenesisPrincipal Investigator

    • Principal Investigator
      ISHIKAWA Fumihiro
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Showa University
  •  A potential role of mitochondria-mediated signaling in induction of malignancy and stemness by TGF.

    • Principal Investigator
      SHIBANUMA Motoko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cell biology
    • Research Institution
      Showa University

All 2023 2022 2021 2020 2019 2017 2016 2012 2011 2010 2009 Other

All Journal Article Presentation

  • [Journal Article] An indispensable role of TAZ in anoikis resistance promoted by OTUB1 deubiquitinating enzyme in basal-like triple-negative breast cancer cells2023

    • Author(s)
      Hidetsugu Nakagawa, Masato Higurashi, Fumihiro Ishikawa, Kazunori Mori, Motoko Shibanuma
    • Journal Title

      Biochem Biophys Res Commun .

      Volume: 649 Pages: 1-9

    • DOI

      10.1016/j.bbrc.2023.01.080

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06917, KAKENHI-PROJECT-22K15516, KAKENHI-PROJECT-21K06809
  • [Journal Article] HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA-less cancer cells2022

    • Author(s)
      Maruyama Tsuyoshi、Saito Koji、Higurashi Masato、Ishikawa Fumihiro、Kohno Yohko、Mori Kazunori、Shibanuma Motoko
    • Journal Title

      Cancer Science

      Volume: 114 Issue: 1 Pages: 152

    • DOI

      10.1111/cas.15582

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K06809, KAKENHI-PROJECT-22K06917, KAKENHI-PROJECT-22K15516
  • [Journal Article] Rac1-mediated sustained β4 integrin level develops reattachment ability of breast cancer cells after anchorage loss.2021

    • Author(s)
      Mori K, Higurashi M, Ishikawa F, Shibanuma M.
    • Journal Title

      Cancer Sci.

      Volume: 112 Issue: 8 Pages: 3205-3217

    • DOI

      10.1111/cas.14985

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07390
  • [Journal Article] Intracellular redox and mitochondrial regulaiton by transforming growth factor-b-its implication in induction of epithelial-mesenchymal transition2016

    • Author(s)
      Motoko Shibanuma, Kazunori Mori, Fumihiro Ishikawa
    • Journal Title

      J. Cell Signal.

      Volume: 印刷中

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26460399
  • [Journal Article] A HIC-5- and KLF4-dependent mechanism transactivates p21(Cip1) in response to anchorage loss.2012

    • Author(s)
      Mori K, Hamanaka H, Oshima Y, Araki Y, Ishikawa F, Nose K, Shibanuma M.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 287 Issue: 46 Pages: 38854-38865

    • DOI

      10.1074/jbc.m112.377721

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590390
  • [Journal Article] Importance of mitochondrial dysfunction in oxidative stress responses : A comparative study of gene expression profiles2011

    • Author(s)
      Shibanuma, M., Inoue, A., Ushida, K., Uchida, T., Ishikawa, F., Mori, K., and Nose, K.
    • Journal Title

      Free Radic. Res

      Volume: 45 Pages: 672-680

    • Data Source
      KAKENHI-PROJECT-21570205
  • [Journal Article] Transcriptional induction of MMP-10 by TGF-β, mediated by activation of MEF2A and downregulation class lla HDACs.2010

    • Author(s)
      Ishikawa, F., Miyoshi, H., Nose, K., Shibanuma, M.
    • Journal Title

      Oncogene 29

      Pages: 909-919

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Journal Article] Transcriptional induction of MMP-10 by TGF-., mediated by activation of MEF2A and down-regulation of class IIa HDACs2010

    • Author(s)
      Ishikawa, F., Miyoshi, H., Nose, K., and Shibanuma, M.
    • Journal Title

      Oncogene

      Volume: 29 Pages: 909-919

    • Data Source
      KAKENHI-PROJECT-21570205
  • [Journal Article] Competitive nuclear export of cyclin D1 and Hic-5 regulates anchorage-dependence of cell growth and survival2009

    • Author(s)
      Mori, K., Hirao, E., Toya, Y., Oshima, Y., Ishikawa, F., Nose, K., and Shibanuma, M.
    • Journal Title

      Mol. Biol Cell

      Volume: 20 Pages: 218-232

    • Data Source
      KAKENHI-PROJECT-21570205
  • [Journal Article] Gene expression profiling identifies a role for CHOP-10 during inhibition of the mitochondrial respiratory chain2009

    • Author(s)
      Ishikawa, F., Akimoto, T., Yamamoto, H., Araki, Y., Yoshie, T., Mori, K., Hayashi, H., Nose, K., and Shibanuma, M.
    • Journal Title

      J. Biochem

      Volume: 146 Pages: 123-132

    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] NAD+-SIRT3/6によるp21Cip1発現制御と癌細胞増殖制御2023

    • Author(s)
      日暮大渡、森一憲、中川 英嗣、石川文博、柴沼質子
    • Organizer
      第82回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06809
  • [Presentation] Polycomb-group protein SUZ12 suppresses anoikis by alleviating oxidative stress in cancer cells2023

    • Author(s)
      Ishikawa F, Mori K, Shibanuma M
    • Organizer
      日本薬学会第143年会(札幌)
    • Data Source
      KAKENHI-PROJECT-18K06969
  • [Presentation] HMGA2/IGFBP1/AKT経路によるP27KIP1分解機構の制御と癌治療標的としての意義2022

    • Author(s)
      丸山剛、齊藤光次、日暮大渡、石川文博、河野葉子、森一憲、柴沼質子
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K06809
  • [Presentation] Role of TAZ in promoting cell survival upon anchorage loss in breast cancer cells2022

    • Author(s)
      Hidetsugu Nakagawa, Fumihiro Ishikawa, Kazunori Mori, Motoko Shibanuma
    • Organizer
      The 81 st annual meeting of the Japanese Cancer Association
    • Data Source
      KAKENHI-PROJECT-22K06917
  • [Presentation] Epigenetic control of p21Cip1 expression and cell proliferation by respiratory chain complex I via NAD+ supply2021

    • Author(s)
      Masato Higurashi, Kazunori Mori, Fumihiro Ishikawa, Motoko Shibanuma
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07390
  • [Presentation] ポリコーム群タンパク質SUZ12は酸化ストレスを緩和することでアノイキスを抑制する2021

    • Author(s)
      石川文博、森一憲、柴沼質子
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K06969
  • [Presentation] Rac1-mediated and sustained β4 integrin expression supports persistence of reattachment ability in breast cancer cells2021

    • Author(s)
      Kazunori Mori, Masato Higurashi, Fumihiro Ishikawa, Motoko Shibanuma
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07390
  • [Presentation] The impact of mitochondrial complex I activity on p21Cip1 expression: the importance of NAD+ levels2020

    • Author(s)
      Kazunori Mori, Masato Higurashi, Fumihiro Ishikawa, Motoko Shibanuma
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07390
  • [Presentation] Impact of mitochondrial complex I activity on cancer cell proliferation: importance of NAD+ levels2019

    • Author(s)
      Mori, K., Higurashi, M., Ishikawa, F., and Shibanuma, M.
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K07390
  • [Presentation] ミトコンドリア呼吸鎖複合体IはNAD+の供給を介してp21Cip1の発現を制御する2019

    • Author(s)
      日暮 大渡、森 一憲、石川 文博、柴沼 質子
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K07390
  • [Presentation] Polycomb group protein SUZ12 suppresses anoikis by alleviating oxidative stress in cancer cells2019

    • Author(s)
      Fumihiro Ishikawa, Kazunori Mori and Motoko Shibanuma
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-18K06969
  • [Presentation] The HIC-5-NOX4-mtROS axis regulates metastasis of RAS-activated cancer cells by affecting MMP9 mRNA stability2017

    • Author(s)
      Kazunori Mori, Tetsu Uchida, Toshihiko Yoshie, Yuko Mizote, Fumihiro Ishikawa, Masato Katsuyama, and Motoko Shibanuma
    • Organizer
      EMBO Conference on Redox Biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08317
  • [Presentation] HIC-5によるNOX4依存性細胞内レドックス制御とMMP-9発現制御2016

    • Author(s)
      森一憲、石川文博、柴沼質子
    • Organizer
      第75回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26460399
  • [Presentation] ポリコームタンパク質SUZ12は乳がん細胞の足場非依存的な生存を促進する2016

    • Author(s)
      石川文博、森一憲、柴沼質子
    • Organizer
      第75回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-08
    • Data Source
      KAKENHI-PROJECT-26460399
  • [Presentation] HIC-5 acts as a negative regulator for MMP-9 expression by inhibiting NOX4 expression in oncogenic RAS-driven cancers2016

    • Author(s)
      Kazunori Mori, Fumihiro Ishikawa, and Motoko Shibanuma
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15K08317
  • [Presentation] 肝細胞がんに対する新規治療戦略:ATM/ATR-HMGA2経路の遮断による老化形質誘導の可能性2016

    • Author(s)
      日暮大渡、斉藤光次、河野葉子、石川文博、森一憲、青木武士、村上雅彦、瀧本雅文、柴沼質子
    • Organizer
      第75回 日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26460399
  • [Presentation] Phenotypic disruption of mammary epithelial cells caused by mitochondrial dysfunction and the underlying Mechanisms2012

    • Author(s)
      Shibanuma, M., Mori, K., Ishikawa, F.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Banff, Albert, Canada
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] Phenotypic disruption of mammary epithelial cells caused by mitochondrial dysfunction and the underlying mechanisms2012

    • Author(s)
      Shibanuma, M., Mori, K., Ishikawa, F.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Banff, Albert, Canada
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] 脱接着誘導性細胞死に伴う細胞内代謝系の変化とその意義2012

    • Author(s)
      磯崎 玄、杉山 祥子、関戸 匡恵、石川 文博、柴沼 質子
    • Organizer
      日本薬学会関東支部大会
    • Place of Presentation
      昭和大学 旗の台キャンパス(東京)
    • Year and Date
      2012-10-13
    • Data Source
      KAKENHI-PROJECT-23790378
  • [Presentation] Impact of mitochondrial transcription/replication downregulation on cell growth/survival and metastatic potential2012

    • Author(s)
      石川 文博、森 一憲、柴沼 質子
    • Organizer
      日本癌学会
    • Place of Presentation
      ホテルロイトン札幌 (札幌)
    • Data Source
      KAKENHI-PROJECT-23790378
  • [Presentation] Adhesion-sensitive transcriptional regulation of p21Cip is dependent on the molecular scaffold HIC-5 and KLF42012

    • Author(s)
      Kazunori Mori, Fumihiro Ishikawa, Motoko Shibanuma
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌
    • Data Source
      KAKENHI-PROJECT-24590390
  • [Presentation] 細胞接着斑蛋白質Hic-5によるがん細胞の足場非依存性増殖/造腫瘍能の抑制性制御2011

    • Author(s)
      森一憲、石川文博、柴沼質子
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] Phenotypic disruption of mammary epithelial cells caused by mitochondrial dysfunction and the underlying mechanisms2011

    • Author(s)
      Shibanuma, M., Mori, K., Ishikawa, F.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] ミトコンドリア機能不全によるEMTプログラムの活性化と上皮形質の破綻2011

    • Author(s)
      柴沼質子、森一憲、石川文博
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] ミトコンドリア機能不全により誘導される上皮細胞形質の変化2010

    • Author(s)
      石川文博、森一憲、柴沼質子
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] ミトコンドリア特異的転写因子TFAM発現抑制による腫瘍の転移能抑制の可能性2010

    • Author(s)
      内田徹、石川文博、森一憲、柴沼質子
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] Mitochondria-mediated signaling cascade plays a role in the regulation of gene expression by TGF2010

    • Author(s)
      Shibanuma, M., Kaneko, E., Sugimoto, T., Wakamatsu, M., Mori, K., Ishikawa, F.
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] ミトコンドリア機能不全により誘導される上皮細胞形質の変化2010

    • Author(s)
      石川文博, 他
    • Organizer
      第69回日本癌学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] ミトコンドリア由来ROSによるTGFβ遺伝子発現の抑制的制御機構の存在について2009

    • Author(s)
      石川文博、金子瑛美、柴沼質子
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] Transcriptional induction of MMP10 by TGF. mediated by MEF2 and class IIa HDACs2009

    • Author(s)
      Ishikawa, F., Kaneko, E., Yoshie, T., Nose, K., Shibanuma, M.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Vancouver, British Columbia, Canada
    • Year and Date
      2009-03-17
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] ミトコンドリア由来ROSによるTGFβ遺伝子発現の抑制的制御機構の存在について2009

    • Author(s)
      石川文博, 金子瑛美, 柴沼質子
    • Organizer
      第32回 日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-10
    • Data Source
      KAKENHI-PROJECT-21570205
  • [Presentation] HIC-5 regulates TGF-b-stimulated MMP-9 expression, anchorage-independent growth, and metastasis of breast cancer cells

    • Author(s)
      Kazunori MORI, Fumihiro ISHIKAWA, Motoko SHIBANUMA
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24590390
  • [Presentation] TRAILはp38 MAPKの活性化を介して脱接着誘導性細胞死を制御する

    • Author(s)
      石川 文博
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-25860247
  • 1.  MORI Kazunori (60349040)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 33 results
  • 2.  SHIBANUMA Motoko (60245876)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 35 results
  • 3.  日暮 大渡 (50882487)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results

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* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

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