MITSUHASHI Shinya 三橋進也

Researcher Number	60526672
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2016: 北海道大学, (連合)農学研究科(研究院), 特任講師 2015: 北海道大学, (連合)農学研究科(研究院), その他 2014: 北海道大学, 大学院農学研究院, 特任講師 2012 – 2014: 北海道大学, (連合)農学研究科(研究院), 特任講師 2009: 北海道大学, 大学院・農学研究院, 学術研究員
Review Section/Research Field	Principal Investigator Applied microbiology Except Principal Investigator Bioorganic chemistry / Wood science / Bioproduction chemistry/Bioorganic chemistry
Keywords	Principal Investigator ポルフィリン / 構造決定 / 単離 / 真正細菌 / 生育因子 / 難培養性微生物 Except Principal Investigator タンデム型不斉エポキシ化 / 構造ー活性相関 / セルレニン / 構造活性相関 … More / 全合成 / エポジムノラクタム / オートファジー / 嫌気条件 / リグニン / ムコン酸 / 生分解 / 嫌気的 / ムコン酸類 / muconic acid / anaerobic culture / muconate / lignin / MF-κB / ATM / リン酸化 / 阻害剤 / 1型ホスファターゼ / トウトマイセチン / RPS3a / IKK / NF-κB / TNFα / PP1 Less

Structure and function of the novel autophagy inducer, (+)-epogymnolactam
- Principal Investigator
  
  Ubukata Makoto
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Hokkaido University
Sphingomonas sp.の生産する異種微生物生育因子の単離・構造決定Principal Investigator
- Principal Investigator
  
  三橋進也
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied microbiology
- Research Institution
  Hokkaido University
The evaluation of anaerobic muconates metabolism and ethanol fermentation
- Principal Investigator
  
  SHIGETOMI Kengo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Wood science
- Research Institution
  Hokkaido University
Focused proteomics of phosphorylated proteins using tautomycetin and its application
- Principal Investigator
  
  UBUKATA Makoto
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Hokkaido University

All 2017 2016 2015 2014 2010 2009 2008 2007 Other

All Journal Article Presentation Patent

[Journal Article] Quercetin inhibits advanced glycation end product formation via chelating metal ions, trapping methylglyoxal, and trapping reactive oxygen species.2017
- Author(s)
  M.N.I. Buiyan, S. Mitsuhashi, K. Shigetomi, and M. Ubukata
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 81 Pages: 882-890
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450135
[Journal Article] Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp. through interspecies mutualism.2016
- Author(s)
  M.N.I. Bhuiyan, R. Takai, S. Mitsuhashi, K. Shigetomi, Y. Tanaka, Y. Kamagata, and M. Ubukata
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 69 Pages: 97-103
- NAID
  120005749616
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450135
[Journal Article] Mycophenolic acid and its derivative as potential chemotherapeutic agents targeting inosine monophosphate dehydrogenase in Trypanosoma congolense.2016
- Author(s)
  K. Suganuma, A.E. Sarwono, S. Mitsuhashi, M. Jxkalski, T. Okada, M. Nthatisi, J. Yamagishi, M. Ubukata, and N. Inoue
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 60 Pages: 4391-4393
- NAID
  120006390948
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450135
[Journal Article] (+)-Epogymnolactam, a novel autophagy iducer from mycerial culture of Gymnopus sp.2015
- Author(s)
  S. Mitsuhashi, C. Shindo, K. Shigetomi, T. Miyamoto, and M. Ubukata
- Journal Title
  
  Phytochemistry
  
  Volume: 114 Pages: 155-159
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450135
[Journal Article] First total synthesis of (+)-epogymnolactam, a novel autophagy inducer2015
- Author(s)
  Y. Okado, K. Shigetomi, S. Mitsuhashi, and M. Ubukata
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 68 Pages: 721-724
- NAID
  120005768785
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26450135
[Journal Article] (+)-Epogymnolactam, a novel autophagy inducer from mycelial culture of Gymnopus sp.2014
- Author(s)
  S. Mitsuhashi, C. Shindo, K. Shigetomi, T. Miyamoto, and M. Ubukata
- Journal Title
  
  Phytochemistry
  
  Volume: なし Pages: 163-167
- DOI
  10.1016/j.phytochem.2014.08.012
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26450135
[Journal Article] Low molecular weight lignin suppresses activation of NF-kB and HTV promoter2008
- Author(s)
  S. Mitsuhashi, et.al.
- Journal Title
  
  BioOrgahic&Medicinal Chelnistry 16
  
  Pages: 2645-2650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19208011
[Journal Article] Tautomycetin suppresses the TNFalpha/NF-kappaB pathway viainhibition of IKK activation.2008
- Author(s)
  S. Mitsuhashi, et.al.
- Journal Title
  
  International Journal of Oncology 33
  
  Pages: 1027-1035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19208011
[Journal Article] Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation2008
- Author(s)
  S. Mitsuhashi, M. Ubukata, 他5名 (7番目)
- Journal Title
  
  Int. J. Oncol. 33
  
  Pages: 1027-1035
- Data Source
  KAKENHI-PROJECT-19208011
[Journal Article] Pyrogallol structure in polyphenol is involved in apoptoshis-induction on HEK293T and K562 cells2008
- Author(s)
  S. Mitsuhashi, M. Ubukata, 他3名 (5番目)
- Journal Title
  
  Molecules 13
  
  Pages: 2998-3006
- Data Source
  KAKENHI-PROJECT-19208011
[Journal Article] Low molecular lignin suppresses activation of NF-κB and HIV-1 promoter2007
- Author(s)
  S. Mitsuhashi, M. Ubukata, 他3名 (5番目)
- Journal Title
  
  Bioorg. Med. Chem. 16
  
  Pages: 2645-2650
- Data Source
  KAKENHI-PROJECT-19208011
[Patent] メイラード反応抑制剤2010
- Inventor(s)
  生方信, 永松龍一郎, 三橋進也
- Industrial Property Rights Holder
  国立大学法人北海道大学
- Industrial Property Number
  2010-038455
- Filing Date
  2010-02-24
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] オートファジー誘導物質(+)-Epogymnolactamの単離・構造決定および全合成2014
- Author(s)
  岡戸祐治、新藤千波耶、重冨顕吾、三橋進也、生方　信
- Organizer
  日本農芸化学会　北海道支部講演会
- Place of Presentation
  北海道大学学術交流会館（札幌市）
- Year and Date
  2014-12-13
- Data Source
  KAKENHI-PROJECT-26450135
[Presentation] Sphingomonas sp.GF9株の生産するCatellibacterium nectariphilum AST4T株生育因子の単離2014
- Author(s)
  三橋進也、Mohammad Nazrul Islam Bhuiyan、重冨顕吾、高井亮吾、鎌形洋一、生方信
- Organizer
  日本農芸化学会2014年度（平成26年度）大会
- Place of Presentation
  神奈川県川崎市明治大学生田キャンパス
- Data Source
  KAKENHI-PROJECT-25660051
[Presentation] Study on the novel substrate of protein phosphatase type 1 using tautomycetin2010
- Author(s)
  Y. Li, S. Mitsuhashi, M. Ubukata
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  東京
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] 北海道産キノコからの抗腫瘍活性物質の単離・構造決定と生物活性試験2010
- Author(s)
  三橋進也, 他
- Organizer
  第60回日本木材学会大会
- Place of Presentation
  宮崎
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] 6-Tuliposide Bの類縁体合成と構造活性相関研究2009
- Author(s)
  重冨顕吾、三橋進也、荘司種明、生方信
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  マリンメッセ福岡(福岡)
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] 生理活性物質トウトマイセチンを使ったPP1の役割と機能解析12009
- Author(s)
  三橋進也、岡田只士、島礼、菊池九二三、生方信
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  マリンメッセ福岡(福岡)
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] 生理活性物質トウトマイセチンを使ったPP1の役割と機能解析12009
- Author(s)
  三橋進也, 岡日只士, 島礼, 菊池九二三, 生方信
- Organizer
  日本農芸化学会2009年度大会
- Place of Presentation
  福岡
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] PP1 positively regulates the Raf/ERK and TNF/NF-κB pathway.2009
- Author(s)
  S.Mitsuhashi, et al.
- Organizer
  BIT Life Science 2nd Annual Cancer World Cancer Congress 2009
- Place of Presentation
  Beijing, China
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] Usage of tautomycetin reveals that protein serin/threonine phophatasel positively regulates NF-・B signaling2008
- Author(s)
  Y. Li, S. Mitsuhashi, M. Ubukata
- Organizer
  日本農芸化学会2008年度大会
- Place of Presentation
  名城大学天白キャンパス(名古屋)
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] Usage of tautomycetin reveals that protein serine/threonine phosphatase 1 positively regulates NF-κB signaling2008
- Author(s)
  Y. Li, S. Mitsuhashi, M. Ubukata
- Organizer
  日本農芸化学会2008年度大会2008年度大会
- Place of Presentation
  名古屋
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] 低分子リグニンによるNF-kBの活性化の抑制2008
- Author(s)
  三橋進也, 岸本崇生, 浦木康光, 生方信
- Organizer
  日本農芸化学会2008年度大会
- Place of Presentation
  名城大学天白キャンパス(名古屋)
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] Analysis of the role of protein phosphatase type 1 in TNFα/NF-κB pathway by using tautomycetin2007
- Author(s)
  Y. Li, S. Mitsuhashi, M. Ubukata
- Organizer
  平成19年度第一回学術講演会
- Place of Presentation
  札幌
- Year and Date
  2007-07-28
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] Analysis of the role of protein phosphatase type 1 in TNF a/NF-kB path way by using tautomycetin2007
- Author(s)
  Y. Li, S. Mitsuhashi, M. Ubukata
- Organizer
  平成19年度第一回合同学術講演会
- Place of Presentation
  北海道大学農学部総合研究棟多目的室(札幌)
- Year and Date
  2007-07-28
- Data Source
  KAKENHI-PROJECT-19208011
[Presentation] Sphingomonas sp.の異種バクテリアに対する増殖因子の探索
- Author(s)
  髙井亮吾、Mohammad Nazrul Islam Bhuiyan、三橋進也、鎌形洋一、生方信
- Organizer
  日本木材学会北海道支部・平成25年度研究発表会
- Place of Presentation
  北海道旭川市大雪クリスタルホール
- Data Source
  KAKENHI-PROJECT-25660051
[Presentation] Growth promoting compound produced by Sphingomonas sp. (GF9) for vigorous growth of Catellibacterium nectariphilum strain AST4T.
- Author(s)
  Mohammad Nazrul Islam Bhuiyan, Shinya Mitsuhashi, Kengo Shigetomi, Yoichi Kamagata, Makoto Ubukata
- Organizer
  平成２５年度公益社団法人日本農芸化学会北海道支部夏期シンポジウム
- Place of Presentation
  北海道旭川市国際会議場
- Data Source
  KAKENHI-PROJECT-25660051

1. UBUKATA Makoto (60168739)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
2. SHIGETOMI Kenngo (20547202)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results

MITSUHASHI Shinya 三橋 進也

Research Projects

Research Products

Co-Researchers

Structure and function of the novel autophagy inducer, (+)-epogymnolactam

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Sphingomonas sp.の生産する異種微生物生育因子の単離・構造決定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The evaluation of anaerobic muconates metabolism and ethanol fermentation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Focused proteomics of phosphorylated proteins using tautomycetin and its application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Quercetin inhibits advanced glycation end product formation via chelating metal ions, trapping methylglyoxal, and trapping reactive oxygen species.2017

Author(s)

Journal Title

Data Source

[Journal Article] Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp. through interspecies mutualism.2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Mycophenolic acid and its derivative as potential chemotherapeutic agents targeting inosine monophosphate dehydrogenase in Trypanosoma congolense.2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] (+)-Epogymnolactam, a novel autophagy iducer from mycerial culture of Gymnopus sp.2015

Author(s)

Journal Title

Data Source

[Journal Article] First total synthesis of (+)-epogymnolactam, a novel autophagy inducer2015

Author(s)

Journal Title

NAID

Data Source

[Journal Article] (+)-Epogymnolactam, a novel autophagy inducer from mycelial culture of Gymnopus sp.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low molecular weight lignin suppresses activation of NF-kB and HTV promoter2008

Author(s)

Journal Title

Data Source

[Journal Article] Tautomycetin suppresses the TNFalpha/NF-kappaB pathway viainhibition of IKK activation.2008

Author(s)

Journal Title

Data Source

[Journal Article] Tautomycetin suppresses the TNFalpha/NF-kappaB pathway via inhibition of IKK activation2008

Author(s)

Journal Title

Data Source

[Journal Article] Pyrogallol structure in polyphenol is involved in apoptoshis-induction on HEK293T and K562 cells2008

Author(s)

Journal Title

Data Source

[Journal Article] Low molecular lignin suppresses activation of NF-κB and HIV-1 promoter2007

Author(s)

Journal Title

Data Source

[Patent] メイラード反応抑制剤2010

Inventor(s)

Industrial Property Rights Holder

Industrial Property Number

MITSUHASHI Shinya 三橋進也