Hirose Yumiko 廣瀬由美子 (堀由美子)

… Alternative Names

堀由美子

Hori Yumiko 堀由美子

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Researcher Number	60528785
Other IDs
Affiliation (Current)	2025: 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 2025: 大阪大学, 大学院医学系研究科, 招へい教員
Affiliation (based on the past Project Information) *help	2024: 大阪大学, 大学院医学系研究科, 招へい教員 2021 – 2023: 独立行政法人国立病院機構大阪医療センター(臨床研究センター), その他部局等, 研究員 2021: 独立行政法人国立病院機構大阪医療センター(臨床研究センター), 医学系研究科, 招へい教員 2018 – 2019: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related Except Principal Investigator Basic Section 57020:Oral pathobiological science-related
Keywords	Principal Investigator PIK3CA / 静脈奇形 / 脈管異常 / シロリムス / mTOR / リンパ管奇形 / TEK / ｍTOR / リンパ管腫 / 脈管奇形 / ｍTOR阻害薬 / 難治性リンパ管異常 / リンパ管異常 … More Except Principal Investigator … More 細胞内ｃAMP / シングルセル解析 / 未分化間葉系幹細胞 / 機能亢進型GNAS変異疾患 / 骨髄間質細胞 / 細網線維 / シグナル伝達異常 / 骨髄間質幹細胞 / 線維性骨異形成症 / 機能亢進型GNAS変異 Less

遺伝子異常に基づく静脈奇形の病態解明・新規治療法開発Principal Investigator
- Principal Investigator
  
  廣瀬由美子 (堀由美子)
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Osaka University
Pathogenesis of fibrous dysplasia using hyperfunctional GNAS-mutant mice and drug discovery
- Principal Investigator
  
  Toyosawa Satoru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Osaka University
Establishing criteria for pathological diagnosis of lymphatic malformation in anticipation of regulatory approval of the mTOR inhibitor sirolimus.Principal Investigator
- Principal Investigator
  
  Hirose Yumiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  National Hospital Organization Osaka National Hospital Institute for Clinical Reserch
Analysis of mTOR Pathway Expression in Lymphatic malformation and Related diseasesPrincipal Investigator
- Principal Investigator
  
  Hori Yumiko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Comprehensive phenotypic and genomic characterization of venous malformations2024
- Author(s)
  Hirose Katsutoshi、Hori Yumiko、Ozeki Michio、Motooka Daisuke、Hata Kenji、Tahara Shinichiro、Matsui Takahiro、Kohara Masaharu、Maruyama Kazuaki、Imanaka-Yoshida Kyoko、Toyosawa Satoru、Morii Eiichi
- Journal Title
  
  Human Pathology
  
  Volume: 145 Pages: 48-55
- DOI
  10.1016/j.humpath.2024.02.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19433, KAKENHI-PROJECT-23K15949, KAKENHI-PROJECT-21K07838, KAKENHI-PROJECT-21K15384, KAKENHI-PROJECT-23K27391
[Journal Article] 血管腫・血管奇形の病理2023
- Author(s)
  堀由美子、森井英一、大須賀慶悟、廣瀬勝俊
- Journal Title
  
  脈管学
  
  Volume: 63 Pages: 85-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15384
[Journal Article] A Case of Multifocal Lymphangioendotheliomatosis With Thrombocytopenia and Changes in Coagulopathy2023
- Author(s)
  Nagao Daiki、Ozeki Michio、Nozawa Akifumi、Yasue Shiho、Sasai Hideo、Endo Saori、Kato Takazumi、Hori Yumiko、Ohnishi Hidenori
- Journal Title
  
  Journal of Pediatric Hematology/Oncology
  
  Volume: 45 Issue: 3 Pages: e384-e388
- DOI
  10.1097/mph.0000000000002597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07838, KAKENHI-PROJECT-21K15384
[Journal Article] Pediatric case of acquired progressive lymphatic anomaly treated with sirolimus2023
- Author(s)
  Komamizu Sayano、Ozeki Michio、Hayashi Daichi、Endo Saori、Hori‐Hirose Yumiko、Sasaki Satoru、Ohnishi Hidenori
- Journal Title
  
  Pediatrics International
  
  Volume: 65 Issue: 1
- DOI
  10.1111/ped.15497
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15384, KAKENHI-PROJECT-21K07838
[Journal Article] これからの脈管異常診療において求められる病理診断2022
- Author(s)
  堀由美子、森井英一、廣瀬勝俊
- Journal Title
  
  診断病理
  
  Volume: 39 Pages: 247-254
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15384
[Journal Article] PIK3CA mutation correlates with mTOR pathway expression but not clinical and pathological features in Fibfibroipose vascular anomaly (FAVA)2022
- Author(s)
  Yumiko Hori, Katsutoshi Hirose, Michio Ozeki, Kenji Hata, Daisuke Motooka, Shinichiro Tahara, Takahiro Matsui, Masaharu Kohara, Hiroki Higashihara, Yusuke Ono, Kaishu Tanaka, Satoru Toyosawa & Eiichi Morii
- Journal Title
  
  Diagnostic Pathology
  
  Volume: 17 Issue: 1 Pages: 19-19
- DOI
  10.1186/s13000-022-01199-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15384, KAKENHI-PROJECT-21K07838, KAKENHI-PROJECT-20K16192
[Journal Article] 血管腫・血管奇形2021
- Author(s)
  堀由美子, 廣瀬勝俊, 眞能正幸, 森井英一
- Journal Title
  
  病理と臨床
  
  Volume: 39 Pages: 1123-1127
- Data Source
  KAKENHI-PROJECT-21K15384
[Journal Article] 特集脈管異常のアップデート- 新ISSVA分類で深める病態の理解- 脈管異常の病理診断2021
- Author(s)
  堀由美子, 廣瀬勝俊, 森井英一
- Journal Title
  
  画像診断
  
  Volume: 41 Issue: 12 Pages: 1199-1207
- DOI
  10.15105/GZ.0000002522
- ISSN
  0285-0524, 2432-1281
- Year and Date
  2021-09-25
- Data Source
  KAKENHI-PROJECT-21K15384
[Journal Article] Analysis of mTOR pathway expression in lymphatic malformation and related diseases.2020
- Author(s)
  Hori Y, Ozeki M, Hirose K, Matsuoka K, Matsui T, Kohara M, Tahara S, Toyosawa S, Fukao T, Morii E.
- Journal Title
  
  Pathology International
  
  Volume: - Issue: 6 Pages: 323-329
- DOI
  10.1111/pin.12913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15079
[Presentation] 線維性異形成症モデルの検討：骨格系幹細胞におけるGsα 構成的活性化が骨形成に及ぼす影響2024
- Author(s)
  兵頭美穂, 廣瀬勝俊, 宇佐美悠, 芝原巧, 豊澤悟
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 線維性異形成症モデルマウスの解析2024
- Author(s)
  廣瀬勝俊, 兵頭美穂, 宇佐美悠, 芝原巧, 豊澤悟
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 線維性異形成症モデルマウスの検討：骨格系幹細胞におけるGsα構成的活性化が骨形成に及ぼす影響2023
- Author(s)
  兵頭美穂, 廣瀬勝俊, 宇佐美悠, 豊澤悟
- Organizer
  歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 静脈奇形におけるTEK遺伝子変異の臨床病理学的意義2023
- Author(s)
  堀由美子、廣瀬勝俊、松井崇浩、豊澤悟、森井英一
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K15384
[Presentation] 線維性異形成症モデルの検討：LepR＋骨髄間質細胞におけるGsalpha構成的活性化が骨2023
- Author(s)
  豊澤悟、阿部真土、廣瀬勝俊、兵頭美穂、宇佐美悠、佐藤淳
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 線維性異形成症モデルの検討：骨格系幹細胞におけるGsα;構成的活性化が骨形成に及ぼす影響2023
- Author(s)
  兵頭美穂、廣瀬勝俊、宇佐美悠、豊澤悟
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 線維性異形成症モデルマウス作製の試み2023
- Author(s)
  兵頭美穂, 廣瀬勝俊, 芝原巧, 宇佐美悠, 鵜澤成一, 豊澤悟
- Organizer
  日本臨床口腔病理学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 線維性骨異形成症の病態解明を目指したモデルマウスの作製2023
- Author(s)
  兵頭美穂, 廣瀬勝俊, 宇佐美悠, 豊澤悟
- Organizer
  日本口腔科学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 血管腫・血管奇形の病態診断2023
- Author(s)
  堀由美子
- Organizer
  第19回血管腫血管奇形学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15384
[Presentation] 血管腫血管奇形診療の最新の知見－血管腫・血管奇形の病理－2022
- Author(s)
  堀由美子, 廣瀬勝俊, 森井英一
- Organizer
  第63回日本脈管学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15384
[Presentation] 線維性異形成症モデルの検討：骨髄間質幹細胞におけるGsα構成的活性化が骨形成に及ぼす影響2022
- Author(s)
  豊澤悟、阿部真土、廣瀬勝俊、宇佐美悠、佐藤淳
- Organizer
  第111回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 3.FFPE検体を用いた、静脈奇形の病理所見・免疫組織化学染色・遺伝子変異の包括的解析2022
- Author(s)
  堀由美子, 小関道夫, 森井英一, 廣瀬勝俊
- Organizer
  第18回日本血管腫血管奇形学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15384
[Presentation] GNAS遺伝子変異マウスを用いたFibrous dysplasia の病態解析2022
- Author(s)
  兵頭美穂、廣瀬勝俊、宇佐美悠、豊澤悟
- Organizer
  第33回日本臨床口腔病理学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 診断・治療に難渋している左大腿脈管性腫瘍の一例2022
- Author(s)
  林大地, 小関道夫, 野沢明文, 遠渡沙緒理, 大西秀典, 加藤充純, 堀由美子
- Organizer
  第18回日本血管腫血管奇形学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15384
[Presentation] Osteocytic constitutive activation of Gαs activity exerts an anabolic effect on the bone.2022
- Author(s)
  Hirose K, Naniwa K, Hyodo M, Usami Y, Abe M, Hata K, Inubushi T, Toyosawa S
- Organizer
  American Society for Bone and Mineral Research 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 脈管奇形の分類－静脈奇形・リンパ管奇形を中心に－2022
- Author(s)
  堀由美子
- Organizer
  第111回日本病理学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15384
[Presentation] 線維性異形成症モデルの検討: 骨髄間質幹細胞におけるGsα構成的活性化が骨形成に及ぼす影響2022
- Author(s)
  豊澤　悟、阿部真土、廣瀬勝俊、宇佐美悠、佐藤　淳
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] ISSVA分類に基づいた「血管腫」の病理診断と従来の分類との対比2021
- Author(s)
  堀　由美子
- Organizer
  第120回日本皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-21K15384
[Presentation] Fibro-adipose vascular anomaly (FAVA) における遺伝子変異と臨床病理学的所見との関連2021
- Author(s)
  堀由美子, 廣瀬勝俊, 小関道夫, 森井英一
- Organizer
  第17回日本血管腫血管奇形学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15384
[Presentation] Fibro-adipose vascular anomaly (FAVA)におけるmTOR関連因子の免疫組織学的検討2021
- Author(s)
  右近琴, 堀由美子, 廣瀬勝俊 , 松井崇浩, 清川博貴, 荒牧典子, 鈴木沙知, 中山ロバート, 井上正則, 森井英一
- Organizer
  第110回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K15384
[Presentation] リンパ管異常症におけるmTOR関連蛋白発現の免疫組織学的検討2019
- Author(s)
  堀由美子、松岡健太郎、森井英一
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K15079
[Presentation] 血管腫・血管奇形の病理診断2019
- Author(s)
  堀由美子
- Organizer
  第16回日本血管腫血管奇形学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15079

1. 廣瀬勝俊 (00824898)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
2. Toyosawa Satoru (30243249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
3. 鵜澤成一 (30345285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 阿部真土 (40448105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 宇佐美悠 (80444579)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. 松井崇浩 (50747037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 田熊一敞 (90289025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OZEKI Michio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 森井英一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirose Yumiko 廣瀬 由美子 (堀 由美子)

堀由美子

Hori Yumiko 堀 由美子

Research Projects

Research Products

Co-Researchers

遺伝子異常に基づく静脈奇形の病態解明・新規治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathogenesis of fibrous dysplasia using hyperfunctional GNAS-mutant mice and drug discovery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishing criteria for pathological diagnosis of lymphatic malformation in anticipation of regulatory approval of the mTOR inhibitor sirolimus.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of mTOR Pathway Expression in Lymphatic malformation and Related diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Comprehensive phenotypic and genomic characterization of venous malformations2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 血管腫・血管奇形の病理2023

Author(s)

Journal Title

Data Source

[Journal Article] A Case of Multifocal Lymphangioendotheliomatosis With Thrombocytopenia and Changes in Coagulopathy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pediatric case of acquired progressive lymphatic anomaly treated with sirolimus2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] これからの脈管異常診療において求められる病理診断2022

Author(s)

Journal Title

Data Source

[Journal Article] PIK3CA mutation correlates with mTOR pathway expression but not clinical and pathological features in Fibfibroipose vascular anomaly (FAVA)2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 血管腫・血管奇形2021

Author(s)

Journal Title

Data Source

[Journal Article] 特集 脈管異常のアップデート- 新ISSVA分類で深める病態の理解- 脈管異常の病理診断2021

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] Analysis of mTOR pathway expression in lymphatic malformation and related diseases.2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 線維性異形成症モデルの検討：骨格系幹細胞におけるGsα 構成的活性化が 骨形成に及ぼす影響2024

Author(s)

Organizer

Data Source

[Presentation] 線維性異形成症モデルマウスの解析2024

Author(s)

Hirose Yumiko 廣瀬由美子 (堀由美子)

Hori Yumiko 堀由美子

[Journal Article] 特集脈管異常のアップデート- 新ISSVA分類で深める病態の理解- 脈管異常の病理診断2021

[Presentation] 線維性異形成症モデルの検討：骨格系幹細胞におけるGsα 構成的活性化が骨形成に及ぼす影響2024

[Presentation] 静脈奇形におけるTEK遺伝子変異の臨床病理学的意義2023