SEGUCHI OSAMU 瀬口理

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SEGUCHI Osamu 瀬口理

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Researcher Number	60570869
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 病院, 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立研究開発法人国立循環器病研究センター, 病院, 客員研究員 2017 – 2021: 国立研究開発法人国立循環器病研究センター, 病院, 医長 2015 – 2016: 国立研究開発法人国立循環器病研究センター, 病院, 医師 2015: 国立循環器病研究センター, 病院, 医師 2014: 独立行政法人国立循環器病研究センター, 病院移植部, 研究員 2012 – 2014: 独立行政法人国立循環器病研究センター, 病院, 医師
Review Section/Research Field	Principal Investigator Cardiovascular medicine / Basic Section 53020:Cardiology-related / Circulatory organs internal medicine Except Principal Investigator Cardiovascular medicine / General surgery / Circulatory organs internal medicine
Keywords	Principal Investigator 劇症型心筋炎 / 筋ジストロフィー / 補助人工心臓 / 重症心不全 / 心臓移植 / 2次性心筋症 / 希少心筋疾患 / 創薬 / 心不全 / 拡張相肥大型心筋症 … More / 肺高血圧 / 先天代謝異常症 / 膜型人工肺 / 臨床 / 移植・再生医療 / 循環器・高血圧 / 機械的循環補助 / 人工心臓 / cardiac-MLCK / ペプチド創薬 / リン酸化酵素 / 遺伝子 / 心筋症 … More Except Principal Investigator 循環器・高血圧 / ゼブラフィッシュ / 補助人工心臓 / 心移植 / 心臓外科 / 人工臓器 / 三尖弁閉鎖不全症 / 大動脈弁閉鎖不全症 / 僧帽弁閉鎖不全症 / 三尖弁閉鎖不全 / 大動脈弁閉鎖不全 / 僧帽弁閉鎖不全 / 左心補助人工心臓 / 遺伝子変異 / 肥大型心筋症 / 虚血性心疾患 / 心筋保護 / 心筋梗塞 / 虚血性疾患 / トランスレーショナルリサーチ / 心筋症 / 心不全 / heart failure / cardiomyopathy / genetics Less

希少心筋疾患に対する重症心不全診療指針の確立Principal Investigator
- Principal Investigator
  
  瀬口理
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Establishment of clinical guidelines for rare cardiac disease complicated by advanced heart failurePrincipal Investigator
- Principal Investigator
  
  Seguchi Osamu
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Analisys valve function and morphorogic change in the patients with long-support LVAD
- Principal Investigator
  
  HATA HIROKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
The role of myosin regulatory light chain phosphorylation in heart diseases
- Principal Investigator
  
  KITAKAZE Msafumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Novel cardiovascular drug discovery based on the cardiac-MLCK signalingsPrincipal Investigator
- Principal Investigator
  
  Osamu Seguchi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Identification and purification of cardiac fibroblast-specific FGF23 receptor
- Principal Investigator
  
  KITAKAZE Masafumi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Analysis of the pathogenesis in hypertophic cardiomyopathy by using zebrafish models.
- Principal Investigator
  
  Hodatsu Akihiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Kanazawa University
Cardiac Myosin Light Chain Kinase Mutation as a Cause of Cardiomyopathies
- Principal Investigator
  
  KONNO Tetsuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kanazawa University
Development of novel drugs for heart failure treatment based on modulating kinase activity of cardiac-MLCKPrincipal Investigator
- Principal Investigator
  
  SEGUCHI Osamu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute

All 2024 2023 2022 2021 2020 2019 2018 2015

All Journal Article Presentation

[Journal Article] Heart transplantation with super-aged donors older than 65 years2024
- Author(s)
  Hada Tasuku、Seguchi Osamu、Kitahata Nana、Komeyama Shotaro、Mochizuki Hiroki、Watanabe Takuya、Kainuma Satoshi、Fukushima Satsuki、Tsukamoto Yasumasa、Fujita Tomoyuki、Kobashigawa Jon、Fukushima Norihide
- Journal Title
  
  JHLT Open
  
  Volume: 4 Pages: 100083-100083
- DOI
  10.1016/j.jhlto.2024.100083
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08413
[Journal Article] Prognostic impact of lung computed tomography density in cardiogenic shock patients with veno‐arterial extracorporeal membrane oxygenation2023
- Author(s)
  Hada Tasuku、Seguchi Osamu、Mochizuki Hiroki、Watanabe Takuya、Tadokoro Naoki、Kainuma Satoshi、Fukushima Satsuki、Tsukamoto Yasumasa、Noguchi Teruo、Fujita Tomoyuki、Fukushima Norihide
- Journal Title
  
  Artificial Organs
  
  Volume: 47 Issue: 11 Pages: 1742-1751
- DOI
  10.1111/aor.14627
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08413, KAKENHI-PROJECT-21H03017
[Journal Article] Successful heart transplantation in a patient with adolescent-onset dilated cardiomyopathy secondary to propionic acidaemia: a case report.2022
- Author(s)
  Seguchi O, Toda K, Hamada Y, Fujita T, Fukushima N.
- Journal Title
  
  Eur Heart J Case Rep.
  
  Volume: 6 Issue: 6
- DOI
  10.1093/ehjcr/ytac202
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08413
[Journal Article] Impact of sleep-disordered breathing on ventricular tachyarrhythmias after left ventricular assist device implantation.2022
- Author(s)
  Kumai Y, Seguchi O, Mochizuki H, Kimura Y, Iwasaki K, Kuroda K, Nakajima S, Matsumoto Y, Watanabe T, Yanase M, Sata M, Fukushima S, Fujita T, Chikamori T, Kobayashi J, Fukushima N.
- Journal Title
  
  J Artif Organs
  
  Volume: 25 Issue: 3 Pages: 223-230
- DOI
  10.1007/s10047-021-01307-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08413, KAKENHI-PROJECT-21H03017, KAKENHI-PROJECT-19K09256
[Journal Article] Pulmonary Vascular Reverse Remodeling After Left Ventricular Assist Device Implantation in Patients With Pulmonary Hypertension.2022
- Author(s)
  Anegawa E, Seguchi O, Mochizuki H, Kuroda K, Doi Nakajima S, Watanabe T, Yanase M, Tadokoro N, Fukushima S, Fujita T, Fukushima N.
- Journal Title
  
  ASAIO J
  
  Volume: 69 Issue: 2 Pages: 151-158
- DOI
  10.1097/mat.0000000000001739
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08413, KAKENHI-PROJECT-19K09256
[Journal Article] Implantation of ventricular assist devices in hypertrophic cardiomyopathy with left ventricular systolic dysfunction.2021
- Author(s)
  Yagi N, Seguchi O, Mochizuki H, Kuroda K, Nakajima S, Watanabe T, Yanase M, Tadokoro N, Fukushima S, Fujita T, Fukushima N.
- Journal Title
  
  ESC Heart Failure
  
  Volume: 8 Issue: 6 Pages: 5513-5522
- DOI
  10.1002/ehf2.13653
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08413
[Journal Article] Mechanical Circulatory Support Combined With Immunosuppression for the Treatment of Giant Cell Myocarditis　― A Single-Center Experience in Japan ―2020
- Author(s)
  Nakajima-Doi S, Mochizuki H, Iwasaki K, Kuroda K, Watanabe T, Tadokoro N, Okada A, Asaumi Y, Kanzaki H, Fukushima S, Seguchi O, Yanase M, Izumi C, Fujita T, Kobayashi J, Fukushima N.
- Journal Title
  
  Circ J
  
  Volume: 84 Issue: 5 Pages: 815-819
- DOI
  10.1253/circj.CJ-19-0847
- NAID
  130007835088
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2020-04-24
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09546, KAKENHI-PROJECT-20K08413
[Journal Article] Impact of cardiac myosin light chain kinase gene mutation on development of dilated cardiomyopathy2019
- Author(s)
  Hodatsu A, Fujino N, Uyama Y, Tsukamoto O, Imai-Okazaki A, Yamazaki S, Seguchi O, Konno T, Hayashi K, Kawashiri MA, Asano Y, Kitakaze M, Takashima S, Yamagishi M
- Journal Title
  
  ESC Heart Fail
  
  Volume: 6 Issue: 2 Pages: 06-415
- DOI
  10.1002/ehf2.12410
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09578, KAKENHI-PROJECT-18K08100, KAKENHI-PROJECT-18H04050, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-15H04826, KAKENHI-PROJECT-19K08553, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-18K15863, KAKENHI-PROJECT-17K09082, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-19H03652
[Journal Article] Heart Transplantation Ameliorates Ambulation Capacity in Patients With Muscular Dystrophy　― An Analysis of 9 Cases ―2019
- Author(s)
  Seguchi O, Kuroda K, Fujita T, Kumai Y, Nakajima S, Watanabe T, Yanase M, Matsumoto Y, Fukushima S, Kimura K, Fukushima N.
- Journal Title
  
  Circ J
  
  Volume: 83 Issue: 3 Pages: 684-686
- DOI
  10.1253/circj.CJ-18-1060
- NAID
  130007603745
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2019-02-25
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09546
[Journal Article] Left ventricular assist device implantation in an adult male with Danon disease.2019
- Author(s)
  Kuroda K, Seguchi O, Matama H, Kimura Y, Iwasaki K, Toda K, Kikuchi N, Kumai Y, Nakajima S, Matsumoto Y, Watanabe T, Yanase M, Fukushima S, Tomoyuki F, Kobayashi J, Fukushima N.
- Journal Title
  
  J Cardiol Cases.
  
  Volume: 3 Issue: 3 Pages: 106-109
- DOI
  10.1016/j.jccase.2019.06.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09546
[Journal Article] Impact of mitral valve intervention with left ventricular assist device implantation on postoperative outcomes and morphologic change2018
- Author(s)
  Hata Hiroki、Fujita Tomoyuki、Ishibashi-Ueda Hatsue、Kuroda Kensuke、Seguchi Osamu、Matsumoto Yorihiko、Yanase Masanobu、Sato Takuma、Nakajima Seiko、Fukushima Norihide、Kobayashi Junjiro
- Journal Title
  
  Journal of Artificial Organs
  
  Volume: 21 Issue: 2 Pages: 164-171
- DOI
  10.1007/s10047-017-1010-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10446
[Presentation] Cardiac Transplantation for Patients with Muscular Dystrophy2019
- Author(s)
  Osamu Seguchi
- Organizer
  60th Annual Meeting of The Japanese Society of Neurology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09546
[Presentation] Cardiac Transplantation in Patients with Muscular Dystrophy2019
- Author(s)
  瀬口　理
- Organizer
  日本神経学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09546
[Presentation] 神経・筋疾患合併心不全に対する植込型補助人工心臓2018
- Author(s)
  瀬口理
- Organizer
  第66回日本心臓病学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09546
[Presentation] Left ventricular Assist Device Support Provides Drastic Restration of Gene Expression Together with Mtocardial Recovery in Patients with Advanced Heart Failure2015
- Author(s)
  Kensuke Kuroda, Osamu Seguchi, et al.
- Organizer
  ISHLT 2015
- Place of Presentation
  Nice, France
- Year and Date
  2015-04-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461138
[Presentation] 左室補助人工心臓装着による病理学的所見の変化2015
- Author(s)
  黒田健輔　瀬口理　その他
- Organizer
  心筋生検研究会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-12-11
- Data Source
  KAKENHI-PROJECT-26461138

1. KITAKAZE Masafumi (20294069)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. TAKASHIMA Seiji (90379272)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. YAMAZAKI Satoru (70348796)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 朝倉正紀 (80443505)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 中野敦 (90648106)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ITO Shin

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. IMAZU Miki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. FUKUDA Hiroki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. KONNO Tetsuo (50377389)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Hodatsu Akihiko (00623662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HATA HIROKI (80638198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 小林順二郎 (20393233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 藤田知之 (10457012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 福嶌教偉 (30263247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 植田初江 (40522983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 松本順彦 (10781908)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 戸田宏一 (40379235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 吉川泰司 (40570594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 堂前圭太郎 (20774219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 吉岡大輔 (40645959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. Kuroda Kensuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. Minamino Naoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. Nishigori Mitsuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. MIN Kyung-Duk

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. SHINDO Kazuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. HITUMOTO Taturo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. NAKAJIMA Yuri

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. ASANO Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. TSUKAMOTO Osamu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SEGUCHI OSAMU 瀬口 理

SEGUCHI Osamu 瀬口 理

Research Projects

Research Products

Co-Researchers

希少心筋疾患に対する重症心不全診療指針の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of clinical guidelines for rare cardiac disease complicated by advanced heart failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analisys valve function and morphorogic change in the patients with long-support LVAD

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of myosin regulatory light chain phosphorylation in heart diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel cardiovascular drug discovery based on the cardiac-MLCK signalingsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and purification of cardiac fibroblast-specific FGF23 receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the pathogenesis in hypertophic cardiomyopathy by using zebrafish models.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cardiac Myosin Light Chain Kinase Mutation as a Cause of Cardiomyopathies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel drugs for heart failure treatment based on modulating kinase activity of cardiac-MLCKPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Heart transplantation with super-aged donors older than 65 years2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic impact of lung computed tomography density in cardiogenic shock patients with veno‐arterial extracorporeal membrane oxygenation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful heart transplantation in a patient with adolescent-onset dilated cardiomyopathy secondary to propionic acidaemia: a case report.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of sleep-disordered breathing on ventricular tachyarrhythmias after left ventricular assist device implantation.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pulmonary Vascular Reverse Remodeling After Left Ventricular Assist Device Implantation in Patients With Pulmonary Hypertension.2022

SEGUCHI OSAMU 瀬口理

SEGUCHI Osamu 瀬口理

[Journal Article] Mechanical Circulatory Support Combined With Immunosuppression for the Treatment of Giant Cell Myocarditis　― A Single-Center Experience in Japan ―2020

[Journal Article] Heart Transplantation Ameliorates Ambulation Capacity in Patients With Muscular Dystrophy　― An Analysis of 9 Cases ―2019