MUKAI Hidefumi 向井英史

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Mukai Hidefumi 向井英史

Hidefumi Mukai 向井英史

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Researcher Number	60570885
Other IDs
Affiliation (Current)	2025: 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 2025: 国立研究開発法人理化学研究所, 仁科加速器科学研究センター, 客員主管研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 2023: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 客員研究員 2021 – 2022: 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー 2018: 国立研究開発法人理化学研究所, 生命機能科学研究センター, ユニットリーダー 2015 – 2017: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー … More 2015: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 上級研究員 2013 – 2014: 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 基礎科学特別研究員 2010 – 2011: 独立行政法人理化学研究所, 分子プローブ動態応用研究チーム, 研究員 Less
Review Section/Research Field	Principal Investigator Tumor therapeutics / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 50:Oncology and related fields / Tumor biology and related fields / Tumor diagnostics / Radiation science Except Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 90120:Biomaterials-related / Respiratory surgery
Keywords	Principal Investigator がん治療 / 合成生物学 / 遺伝子改変細菌 / 細菌 / 細胞治療 / がん / PETイメージング / 生菌製剤 / 人工冬眠 / 細胞療法 … More / がん微小環境 / 一酸化窒素 / ペプチド / 抗体 / セラグノーシス / ナノ粒子 / 腫瘍環境応答 / 抗癌タンパク / 癌治療 / 抗がんタンパク / PET / 64Cu標識 / 神経接着分子 … More Except Principal Investigator 肝炎 / 放射標識 / ｍRNA / 脂質ナノ粒子 / PETイメージング / アップコンバージョン / DDS / 光線力学療法 / 無機ナノ粒子 / アップコンバージョン効果 / mRNA / ワクチン / 多色深部イメージング / 標的指向化 / ドラッグデリバリーシステム / Met / 環状ペプチド / 薬剤耐性 / イメージング / MET / HGF Less

PETを用いた肝疾患病態におけるmRNA内封脂質ナノ粒子の動態―遺伝子発現相関研究
- Principal Investigator
  
  毛利浩太
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Nagasaki University
人工冬眠マウスモデルを用いた新規がん治療標的の探索Principal Investigator
- Principal Investigator
  
  向井英史
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Nagasaki University
Development of innovative T cell-inducing vaccine drug based on mRNA delivery
- Principal Investigator
  
  Kawakami Shigeru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Nagasaki University
アップコンバージョンナノ粒子を基盤とした光線力学療法用製剤の開発
- Principal Investigator
  
  毛利浩太
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagasaki University
  Institute of Physical and Chemical Research
難治性がん治療用デザイナー細菌の開発Principal Investigator
- Principal Investigator
  
  向井英史
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Nagasaki University
Cancer microenvironmental remodeling with NO-producing bacterial machinePrincipal Investigator
- Principal Investigator
  
  Mukai Hidefumi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  Nagasaki University
  Institute of Physical and Chemical Research
Studies of drug resistance and micro-metastasis using macrocyclic peptides as molecular imaging probes
- Principal Investigator
  
  Hiroki Sato
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Respiratory surgery
- Research Institution
  Kanazawa University
Discovery of Cytotoxic T Lymphocyte-inspired Bacteria Machine for Cancer Therapeutic Use Based on Synthetic Biological ApproachPrincipal Investigator
- Principal Investigator
  
  Mukai Hidefumi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Institute of Physical and Chemical Research
Development of Therapeutic Bacteria Machine Packaging with the Production System of Anti-Cancer ProteinPrincipal Investigator
- Principal Investigator
  
  Hidefumi Mukai
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Institute of Physical and Chemical Research
Sophisticate Design of Nano-Particular Type PET Probes for Qualitative Diagnosis and Theragnosis of CancerPrincipal Investigator
- Principal Investigator
  
  Mukai Hidefumi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Institute of Physical and Chemical Research
PET imaging of neural specific cell adhesion molecule as an indication of axonal regenerationPrincipal Investigator
- Principal Investigator
  
  MUKAI Hidefumi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  The Institute of Physical and Chemical Research

All 2023 2022 2021 2018 2016 2015 2014 2013 2012 2011

All Journal Article Presentation Patent

[Journal Article] Effect of Cholesterol Content of Lipid Composition in mRNA-LNPs on the Protein Expression in the Injected Site and Liver After Local Administration in Mice2023
- Author(s)
  Kawaguchi Maho、Noda Marin、Ono Akari、Kamiya Mariko、Matsumoto Makoto、Tsurumaru Masako、Mizukami Shusaku、Mukai Hidefumi、Kawakami Shigeru
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 112 Issue: 5 Pages: 1401-1410
- DOI
  10.1016/j.xphs.2022.12.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03818
[Journal Article] Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives2023
- Author(s)
  Sugimoto Yuri、Suga Tadaharu、Umino Mizuki、Yamayoshi Asako、Mukai Hidefumi、Kawakami Shigeru
- Journal Title
  
  Drug Delivery
  
  Volume: 30 Issue: 1 Pages: 2191891-2191891
- DOI
  10.1080/10717544.2023.2191891
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-22H00593, KAKENHI-PROJECT-21H03818
[Journal Article] Influence of lipid composition of messenger RNA-loaded lipid nanoparticles on the protein expression via intratracheal administration in mice2023
- Author(s)
  Geng Longjian, Kato Naoya, Kodama Yukinobu, Mukai Hidefumi, Kawakami Shigeru
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 637 Pages: 122896-122896
- DOI
  10.1016/j.ijpharm.2023.122896
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J21334, KAKENHI-PROJECT-21H03818
[Journal Article] Microfluidic Post-Insertion Method for the Efficient Preparation of PEGylated Liposomes Using High Functionality and Quality Lipids2022
- Author(s)
  Sugimoto Yuri、Suga Tadaharu、Kato Naoya、Umino Mizuki、Yamayoshi Asako、Mukai Hidefumi、Kawakami Shigeru
- Journal Title
  
  International Journal of Nanomedicine
  
  Volume: Volume 17 Pages: 6675-6686
- DOI
  10.2147/ijn.s390866
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-22H00593, KAKENHI-PROJECT-21H03818, KAKENHI-PROJECT-20J21334
[Journal Article] Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics2022
- Author(s)
  Mukai Hidefumi, Ogawa Koki, Kato Naoya, Kawakami Shigeru
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 44 Pages: 100450-100450
- DOI
  10.1016/j.dmpk.2022.100450
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J21334, KAKENHI-PROJECT-21H03818
[Journal Article] Stability Study of mRNA-Lipid Nanoparticles Exposed to Various Conditions Based on the Evaluation between Physicochemical Properties and Their Relation with Protein Expression Ability2022
- Author(s)
  Kamiya Mariko、Matsumoto Makoto、Yamashita Kazuma、Izumi Tatsunori、Kawaguchi Maho、Mizukami Shusaku、Tsurumaru Masako、Mukai Hidefumi、Kawakami Shigeru
- Journal Title
  
  Pharmaceutics
  
  Volume: 14 Issue: 11 Pages: 2357-2357
- DOI
  10.3390/pharmaceutics14112357
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03818
[Journal Article] The current situation and perspectives of mRNA delivery to the kidney2022
- Author(s)
  Kawaguchi Maho、Kato Naoya、Kamiya Mariko、Mukai Hidefumi、Kawakami Shigeru
- Journal Title
  
  Drug Delivery System
  
  Volume: 37 Issue: 3 Pages: 253-262
- DOI
  10.2745/dds.37.253
- ISSN
  0913-5006, 1881-2732
- Year and Date
  2022-07-25
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03818, KAKENHI-PROJECT-20J21334
[Journal Article] Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain2022
- Author(s)
  Ogawa Koki、Kato Naoya、Yoshida Michiharu、Hiu Takeshi、Matsuo Takayuki、Mizukami Shusaku、Omata Daiki、Suzuki Ryo、Maruyama Kazuo、Mukai Hidefumi、Kawakami Shigeru
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 348 Pages: 34-41
- DOI
  10.1016/j.jconrel.2022.05.042
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09328, KAKENHI-PROJECT-22K12849, KAKENHI-PROJECT-20H04519, KAKENHI-PROJECT-20H04542, KAKENHI-PROJECT-20H04554, KAKENHI-PROJECT-21H03818, KAKENHI-PROJECT-20J21334, KAKENHI-PROJECT-21K15554
[Patent] 脂質性化合物、リポソーム、エクソソーム、脂質ナノ粒子及びドラッグデリバリーシステム2022
- Inventor(s)
  川上茂, 向井英史, 杉本友里, 海野水綺, 神谷万里子
- Industrial Property Rights Holder
  長崎大学
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] Development of local expression mRNA-loaded lipid nanoparticles based on a modification of novel peptide lipids2023
- Author(s)
  Mariko Kamiya, Makoto Matsumoto, Mizuki Umino, Hidefumi Mukai, Shigeru Kawakami
- Organizer
  2023 ICCP450/JSSX International Joint Meeting in Shizuoka
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] Ifluence of lipid composition of messenger RNA-loaded lipid nanoparticles on the protein expression via intratracheal administration in mice2023
- Author(s)
  Geng Longjian, Makoto Matsumoto, Mizuki Umino, Mariko Kamiya, Hidefumi Mukai, Shigeru Kawakami
- Organizer
  第28回創剤フォーラム若手研究会
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] mRNA 封入脂質ナノ粒子における KK ペプチド脂質の修飾量が物理化学的性質および肺における発現に及ぼす影響2023
- Author(s)
  大貝洋一郎, Geng Longjian, Yao Feijie, 神谷万里子, 向井英史, 川上茂
- Organizer
  日本バイオマテリアル学会2023年度九州ブロック研究発表会
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] In vivo での投与部位選択的高発現を目指した KK 脂質修飾 mRNA 封入脂質ナノ粒子の開発2023
- Author(s)
  神谷万里子, 向井英史, 川上茂
- Organizer
  遺伝子・デリバリー研究会第 22 回シンポジウム
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] mRNA封入脂質ナノ粒子の保存条件が物理化学的性質および発現に及ぼす影響2022
- Author(s)
  神谷万里子, 松本眞, 泉龍昇, 三浦樹幸, 向井英史, 川上茂
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] エレクトロポレーション法およびLNPを用いた樹状細胞への遺伝子およびmRNA導入法による発現特性ならびに抗原提示能の比較2022
- Author(s)
  神谷万里子, 実政澪, 仙波紗英, 山下和真, 松本眞, 泉龍昇, 三浦樹幸, 鶴丸雅子, 向井英史, 川上茂
- Organizer
  遺伝子・デリバリー研究会第21回シンポジウム
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] アップコンバージョンナノ粒子の表面修飾技術と体内動態特性評価2022
- Author(s)
  毛利浩太，造田真希，向井英史
- Organizer
  日本薬剤学会第3回超分子薬剤学FGシンポジウム
- Data Source
  KAKENHI-PROJECT-21K07207
[Presentation] mRNA封入脂質ナノ粒子の安定性、物理化学的性質、タンパク質発現の相関の評価2022
- Author(s)
  神谷万里子, 松本眞, 川口真帆, 水上修作, 向井英史, 川上茂
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] 筋肉内投与における脂質ナノ粒子コレステロール含有量のタンパク発現分布への影響2022
- Author(s)
  川口真帆, 小野亜佳莉, 神谷万里子, 水上修作, 向井英史, 川上茂
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] Luciferase mRNA封入脂質ナノ粒子の保存安定性に関する研究2021
- Author(s)
  神谷万里子, 川口真帆, 小野亜佳莉, 鶴丸雅子, 水上修作, 向井英史, 川上茂
- Organizer
  日本薬剤学会第2回超分子薬剤学FGシンポジウム
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] 核酸・mRNA医薬品ナノ粒子製剤の動態評価手法2021
- Author(s)
  向井英史, 川上茂
- Organizer
  日本薬物動態学会第36年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H03818
[Presentation] 静脈内投与後腫瘍組織に生着した大腸菌のプラスミド維持の評価2018
- Author(s)
  野村祥子、Erike Sukowati、高橋麻衣子、渡辺恭良、向井英史
- Organizer
  第34回日本DDS学会
- Data Source
  KAKENHI-PROJECT-17K19622
[Presentation] 核酸創薬におけるポジトロンエミッショントモグラフィーの活用2016
- Author(s)
  向井英史、渡辺恭良
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（横浜県・横浜市）
- Data Source
  KAKENHI-PROJECT-25710011
[Presentation] 生理条件下代謝開裂部位導入による64Cu標識ボンベシンアナログテトラマーを用いた癌PETイメージングの画像コントラスト改善2015
- Author(s)
  松村一史、向井英史、造田真希、高橋麻衣子、林中恵美、山下富義、橋田充、和田康弘、渡辺恭良
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  京王プラザホテル（東京都・新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-25710011
[Presentation] PETを中心とした分子イメージングによる個体レベルでの病態解明と診断・創薬への展開2015
- Author(s)
  向井英史、渡辺恭良
- Organizer
  日本分析化学会第64年会
- Place of Presentation
  九州大学伊都キャンパス（福岡県・福岡市）
- Invited
- Data Source
  KAKENHI-PROJECT-25710011
[Presentation] 64Cu標識前立腺癌標的ペプチドDUP-1の化学修飾がもたらす代謝安定性と腫瘍集積性の向上2014
- Author(s)
  松村一史、向井英史、造田真希、高橋麻衣子、林中恵美、山下富義、橋田充、和田康弘、渡辺恭良
- Organizer
  日本分子イメージング学会　第9回学会総会・学術集会
- Place of Presentation
  大阪府豊中市、千里ライフサイエンスセンター
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-25710011
[Presentation] 腫瘍組織内抗癌タンパク産生B. choshinensisの作製と抗腫瘍効果2014
- Author(s)
  向井英史、高橋麻衣子、渡辺恭良
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-30
- Data Source
  KAKENHI-PROJECT-25640095
[Presentation] Potential use of engineered B. choshinensis in in situ TNF-alpha production machine in the tumor of xenograft mice and its antitumor effects2014
- Author(s)
  Hidefumi Mukai, Maiko Takahashi, Yasuyoshi Watanabe
- Organizer
  41st Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-07-13
- Data Source
  KAKENHI-PROJECT-25640095
[Presentation] 化学修飾による64Cu標識ペプチドPETプローブの高機能化2014
- Author(s)
  松村一史、向井英史、造田真希、高橋麻衣子、林中恵美、山下富義、橋田充、和田康弘、渡辺恭良
- Organizer
  第54回生命科学夏の学校
- Place of Presentation
  滋賀県高島市、白浜荘
- Year and Date
  2014-08-29
- Data Source
  KAKENHI-PROJECT-25710011
[Presentation] 核酸医薬と分子イメージング2014
- Author(s)
  向井英史，渡辺恭良
- Organizer
  第5回探索臨床試験研究会
- Place of Presentation
  京都市
- Invited
- Data Source
  KAKENHI-PROJECT-25710011
[Presentation] Sturucture/biodistribution relationship of multi-arm PEGylated 64Cu-bombesin analogs as tumor imaging PET probes2014
- Author(s)
  Kazushi Matsumura, Hidefumi Mukai, Maki Zouda, Maiko Takahashi, Emi Hayashinaka, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida, Yasuhiro Wada, Yasuyoshi Watanabe
- Organizer
  2014 World Molecular Imaging Congress
- Place of Presentation
  Seoul, Korea, COEX Convention Center
- Year and Date
  2014-09-19
- Data Source
  KAKENHI-PROJECT-25710011
[Presentation] 適度な血中循環の延長と多点認識を目指した化学修飾による癌PETイメージング用ペプチドプロ―ブの改良2014
- Author(s)
  松村　一史、向井　英史、造田　真希、高橋　麻衣子、林中　恵美、川上　茂、山下　富義、橋田　充、和田　康弘、渡辺　恭良
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市　熊本大学
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-25710011
[Presentation] 樹状型ポリエチレングリコール修飾によるボンベシンアナログ誘導体PETプローブの腫瘍内貯留性向上2014
- Author(s)
  向井英史、松村一史、造田真希、高橋麻衣子、林中恵美、山下富義、橋田充、和田康弘、渡辺恭良
- Organizer
  日本分子イメージング学会　第9回学会総会・学術集会
- Place of Presentation
  大阪府豊中市、千里ライフサイエンスセンター
- Year and Date
  2014-05-23
- Data Source
  KAKENHI-PROJECT-25710011
[Presentation] 遺伝子改変B. choshinensisのがん治療における有用性2014
- Author(s)
  向井英史、高橋麻衣子、渡辺恭良
- Organizer
  平成26年度　がん若手研究者ワークショップ
- Place of Presentation
  長野県茅野市
- Year and Date
  2014-09-03
- Data Source
  KAKENHI-PROJECT-25640095
[Presentation] 核酸医薬・DDS開発におけるPETイメージング2013
- Author(s)
  向井英史，渡辺恭良
- Organizer
  第29回日本DDS学会学術集会
- Place of Presentation
  京都市　京都テルサ
- Year and Date
  2013-07-04
- Data Source
  KAKENHI-PROJECT-25710011
[Presentation] 未来の創薬・医療と分子イメージング技術～Drug Delivery System開発への応用を例として～2012
- Author(s)
  向井英史
- Organizer
  神戸学院大学ライフサイエンス産学連携研究センターLSC学術講演会
- Place of Presentation
  神戸市
- Year and Date
  2012-03-09
- Data Source
  KAKENHI-PROJECT-22791233
[Presentation] 分子イメージング技術とDDS開発の接点2011
- Author(s)
  向井英史,渡辺恭良
- Organizer
  第1回DDS製剤臨床応用フォーカスグループ合宿討論会
- Place of Presentation
  神奈川県箱根町
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22791233

1. Kawakami Shigeru (20322307)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. 毛利浩太 (30723697)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. Hiroki Sato (20781173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 砂川玄志郎 (70710250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 水上修作 (00508971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. 土居久志 (00421818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 坂本啓 (10528300)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 片岡洋祐 (40291033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 櫻井文教 (70370939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 山吉麻子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 日宇健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 松尾孝之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MUKAI Hidefumi 向井 英史

Mukai Hidefumi 向井 英史

Hidefumi Mukai 向井 英史

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PETを用いた肝疾患病態におけるmRNA内封脂質ナノ粒子の動態―遺伝子発現相関研究

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人工冬眠マウスモデルを用いた新規がん治療標的の探索Principal Investigator

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Development of innovative T cell-inducing vaccine drug based on mRNA delivery

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アップコンバージョンナノ粒子を基盤とした光線力学療法用製剤の開発

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難治性がん治療用デザイナー細菌の開発Principal Investigator

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Cancer microenvironmental remodeling with NO-producing bacterial machinePrincipal Investigator

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Studies of drug resistance and micro-metastasis using macrocyclic peptides as molecular imaging probes

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Discovery of Cytotoxic T Lymphocyte-inspired Bacteria Machine for Cancer Therapeutic Use Based on Synthetic Biological ApproachPrincipal Investigator

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Development of Therapeutic Bacteria Machine Packaging with the Production System of Anti-Cancer ProteinPrincipal Investigator

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Sophisticate Design of Nano-Particular Type PET Probes for Qualitative Diagnosis and Theragnosis of CancerPrincipal Investigator

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PET imaging of neural specific cell adhesion molecule as an indication of axonal regenerationPrincipal Investigator

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[Journal Article] Effect of Cholesterol Content of Lipid Composition in mRNA-LNPs on the Protein Expression in the Injected Site and Liver After Local Administration in Mice2023

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[Journal Article] Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives2023

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MUKAI Hidefumi 向井英史

Mukai Hidefumi 向井英史

Hidefumi Mukai 向井英史

[Presentation] mRNA 封入脂質ナノ粒子における KK ペプチド脂質の修飾量が物理化学的性質および肺における発現に及ぼす影響2023

[Presentation] In vivo での投与部位選択的高発現を目指した KK 脂質修飾 mRNA 封入脂質ナノ粒子の開発2023