ABE Kazuhiro 阿部一啓

Researcher Number	60596188
Other IDs	https://orcid.org/0000-0003-2681-5921
Affiliation (Current)	2025: 北海道大学, 理学研究院, 教授
Affiliation (based on the past Project Information) *help	2024: 北海道大学, 理学研究院, 教授 2015 – 2023: 名古屋大学, 細胞生理学研究センター, 准教授 2012 – 2015: 名古屋大学, 細胞生理学研究センター, 助教 2014: 名古屋大学, 大学院創薬科学研究科/細胞生理学研究センター, 助教
Review Section/Research Field	Principal Investigator Functional biochemistry / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Biophysics
Keywords	Principal Investigator P型ATPase / 膜タンパク質 / 胃プロトンポンプ / 能動輸送体 / P-type ATPase / 膜輸送体 / プロトンポンプ / Cryo-EM / 構造解析 / 生化学 … More / 電子線結晶学 / 極低温電子顕微鏡 / フリッパーゼ / 脂質 / AI / structgural biology / biochemistry / Flippase / gastric proton pump / membrane protein / 蛋白質 / P-type ATPases / 構造生物学 / Cryo EM / X線結晶構造解析 / 胃 / 機能生物化学 / H,K-ATPase / 電子顕微鏡 / 生体エネルギー変換 … More Except Principal Investigator 膜タンパク質 / 電子線結晶学 / 構造生物学 / H+,K+-ATPase / 水チャネル / 膜タンパク質の生理機能 / 単粒子解析法 / 結晶学 / 単粒子解析 / チャネル / 構造生理学 / クライオ電子顕微鏡 / H+K+-ATPase / H+, K+-ATPase / アクアポリン-4 / 三次元構造 / 電子顕微鏡 / aquaporin-4 / アクアポリン / 二次元結晶 / 高分解能電子顕微鏡解析 / プロトンポンプ / 構造解析 / ナトリウムチャネル / アセチルコリン受容体 / クローディン / ギャップ結合チャネル / イオンチャネル Less

物質不均衡分布形成原理の理解を目指した能動輸送体P型ATPaseの構造機能生理学Principal Investigator
- Principal Investigator
  
  阿部一啓
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Hokkaido University
Strucutral physiology of P-type ATPasesPrincipal Investigator
- Principal Investigator
  
  ABE Kazuhiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Nagoya University
Structural physiology of the gastric proton pumpPrincipal Investigator
- Principal Investigator
  
  Abe Kazuhiro
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Nagoya University
Studies in structural physiology of channels
- Principal Investigator
  
  FUJIYOSHI Yoshinori
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biophysics
- Research Institution
  Tokyo Medical and Dental University
  Nagoya University
Investigation for the mechanism of the gastric proton pump that generates the steepest cation gradientPrincipal Investigator
- Principal Investigator
  
  Abe Kazuhiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Nagoya University
Unique mechanisms of gastric proton pump revealed byPrincipal Investigator
- Principal Investigator
  
  ABE Kazuhiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Functional biochemistry
- Research Institution
  Nagoya University
Structural and functional study of membrane proteins based on electron crystallography
- Principal Investigator
  
  FUJIYOSHI Yoshinori
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University
  Kyoto University
Electron crystallographic analysis of two dimensional crystals of membrane proteins maintaining proton gradient
- Principal Investigator
  
  TANI Kazutoshi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University
  Kyoto University

[Journal Article] Specific protonation of acidic residues confers K+ selectivity to the gastric proton pump2024
- Author(s)
  Madapally Hridya Valia、Abe Kazuhiro、Dubey Vikas、Khandelia Himanshu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 1 Pages: 105542-105542
- DOI
  10.1016/j.jbc.2023.105542
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02426
[Journal Article] Deep learning driven de novo drug design based on gastric proton pump structures2023
- Author(s)
  Abe Kazuhiro、Ozako Mami、Inukai Miki、Matsuyuki Yoe、Kitayama Shinnosuke、Kanai Chisato、Nagai Chiaki、Gopalasingam Chai C.、Gerle Christoph、Shigematsu Hideki、Umekubo Nariyoshi、Yokoshima Satoshi、Yoshimori Atsushi
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 956-956
- DOI
  10.1038/s42003-023-05334-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02426
[Journal Article] An unusual conformation from Na+-sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na+-binding2023
- Author(s)
  Abe Kazuhiro、Nishizawa Tomohiro、Artigas Pablo
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1870 Issue: 7 Pages: 119543-119543
- DOI
  10.1016/j.bbamcr.2023.119543
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02426
[Journal Article] A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities2023
- Author(s)
  Artigas Pablo、Meyer Dylan J.、Young Victoria C.、Spontarelli Kerri、Eastman Jessica、Strandquist Evan、Rui Huan、Roux Beno?t、Birk Matthew A.、Nakanishi Hanayo、Abe Kazuhiro、Gatto Craig
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 52
- DOI
  10.1073/pnas.2313999120
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02426
[Journal Article] Three structures of PSI-LHCI from Chlamydomonas reinhardtii suggest a resting state re-activated by ferredoxin2023
- Author(s)
  Gerle Christoph、Misumi Yuko、Kawamoto Akihiro、Tanaka Hideaki、Kubota-Kawai Hisako、Tokutsu Ryutaro、Kim Eunchul、Chorev Dror、Abe Kazuhiro、Robinson Carol V.、Mitsuoka Kaoru、Minagawa Jun、Kurisu Genji
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Bioenergetics
  
  Volume: 1864 Issue: 4 Pages: 148986-148986
- DOI
  10.1016/j.bbabio.2023.148986
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23H04958, KAKENHI-PROJECT-21H02417, KAKENHI-PROJECT-21H02426
[Journal Article] Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms2022
- Author(s)
  Young Victoria C.、Nakanishi Hanayo、Meyer Dylan J.、Nishizawa Tomohiro、Oshima Atsunori、Artigas Pablo、Abe Kazuhiro
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 5270-5270
- DOI
  10.1038/s41467-022-32793-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03165, KAKENHI-PROJECT-21H02426
[Journal Article] Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump2022
- Author(s)
  Tanaka Saki、Morita Mikio、Yamagishi Tatsuya、Madapally Hridya Valia、Hayashida Kenichi、Khandelia Himanshu、Gerle Christoph、Shigematsu Hideki、Oshima Atsunori、Abe Kazuhiro
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 65 Issue: 11 Pages: 7843-7853
- DOI
  10.1021/acs.jmedchem.2c00338
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19215, KAKENHI-PROJECT-19H03165, KAKENHI-PROJECT-21H02426
[Journal Article] Cryo-EM of the ATP11C flippase reconstituted in Nanodiscs shows a distended phospholipid bilayer inner membrane around transmembrane helix 22022
- Author(s)
  Nakanishi Hanayo、Hayashida Kenichi、Nishizawa Tomohiro、Oshima Atsunori、Abe Kazuhiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 1 Pages: 101498-101498
- DOI
  10.1016/j.jbc.2021.101498
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06064, KAKENHI-PROJECT-21K19215, KAKENHI-PROJECT-20H03216, KAKENHI-PROJECT-21H02426
[Journal Article] Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations2021
- Author(s)
  Abe Kazuhiro、Yamamoto Kenta、Irie Katsumasa、Nishizawa Tomohiro、Oshima Atsunori
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 5709-5709
- DOI
  10.1038/s41467-021-26024-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03216, KAKENHI-PROJECT-20K09193, KAKENHI-PROJECT-21K19215, KAKENHI-PROJECT-21H02426
[Journal Article] Crystal structure of a human plasma membrane phospholipid flippase2020
- Author(s)
  Nakanishi Hanayo、Irie Katsumasa、Segawa Katsumori、Hasegawa Kazuya、Fujiyoshi Yoshinori、Nagata Shigekazu、Abe Kazuhiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 30 Pages: 10180-10194
- DOI
  10.1074/jbc.ra120.014144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05785, KAKENHI-PROJECT-20H00451, KAKENHI-PROJECT-17H03653, KAKENHI-PROJECT-18H02615, KAKENHI-PROJECT-19K22394
[Journal Article] Isoform-selective regulation of mammalian cryptochromes2020
- Author(s)
  Miller Simon、Son You Lee、Aikawa Yoshiki、Makino Eri、Nagai Yoshiko、Srivastava Ashutosh、Oshima Tsuyoshi、Sugiyama Akiko、Hara Aya、Abe Kazuhiro、Hirata Kunio、Oishi Shinya、Hagihara Shinya、Sato Ayato、Tama Florence、Itami Kenichiro、Kay Steve A.、Hatori Megumi、Hirota Tsuyoshi
- Journal Title
  
  Nature Chemical Biology
  
  Volume: - Issue: 6 Pages: 676-685
- DOI
  10.1038/s41589-020-0505-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19171, KAKENHI-PROJECT-18H02555, KAKENHI-PROJECT-19H05463, KAKENHI-PROJECT-17H03653, KAKENHI-PROJECT-18H02402, KAKENHI-PROJECT-18K06316, KAKENHI-PROJECT-19K22693, KAKENHI-PROJECT-19H03266
[Journal Article] Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids2020
- Author(s)
  Burendei Batuujin、Shinozaki Ruriko、Watanabe Masakatsu、Terada Tohru、Tani Kazutoshi、Fujiyoshi Yoshinori、Oshima Atsunori
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 7
- DOI
  10.1126/sciadv.aax3157
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-19H03165, KAKENHI-PROJECT-17K19347, KAKENHI-PROJECT-17H03683
[Journal Article] Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM2020
- Author(s)
  Nakanishi Hanayo、Nishizawa Tomohiro、Segawa Katsumori、Nureki Osamu、Fujiyoshi Yoshinori、Nagata Shigekazu、Abe Kazuhiro
- Journal Title
  
  Cell Reports
  
  Volume: 32 Issue: 13 Pages: 108208-108208
- DOI
  10.1016/j.celrep.2020.108208
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05785, KAKENHI-PROJECT-20H00451, KAKENHI-PROJECT-17H03653, KAKENHI-PROJECT-18H02615, KAKENHI-PROJECT-19K22394, KAKENHI-PROJECT-20H03216
[Journal Article] Isoform-selective regulation of mammalian cryptochromes2020
- Author(s)
  Simon Miller, You Lee Son, Yoshiki Aikawa, Eri Makino, Yoshiko Nagai, Ashutosh Srivastava, Tsuyoshi Oshima, Akiko Sugiyama, Aya Hara, Kazuhiro Abe, Kunio Hirata, Shinya Oishi, Shinya Hagihara, Ayato Sato, Florence Tama, Kenichiro Itami, Steve A. Kay, Megumi Hatori & Tsuyoshi Hirota
- Journal Title
  
  Nat. Chem. Biol.
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03653
[Journal Article] Purified F-ATP synthase forms a Ca2+dependent high-conductance channel matching the mitochondrial permeability transition pore.2019
- Author(s)
  Urbani A,Giorgio V,Carrer A, Franchin C,Arrigoni G, Jiko C,Abe K,Maeda S, Sginzawa-Itoh K, Bogers JF, McMillan DG, Gerle C, Szabo I, Bernardi P
- Journal Title
  
  Nature communications
  
  Volume: 4341 Issue: 1 Pages: 4341-4341
- DOI
  10.1038/s41467-019-12331-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15749, KAKENHI-PROJECT-17H03646, KAKENHI-PROJECT-17H03647, KAKENHI-PROJECT-17H03653
[Journal Article] A single K+-binding site in the crystal structure of the gastric proton pump2019
- Author(s)
  Yamamoto Kenta、Dubey Vikas、Irie Katsumasa、Nakanishi Hanayo、Khandelia Himanshu、Fujiyoshi Yoshinori、Abe Kazuhiro
- Journal Title
  
  eLife
  
  Volume: 8
- DOI
  10.7554/elife.47701
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-17H03653, KAKENHI-PROJECT-17K17795
[Journal Article] K+ binding and proton redistribution in the E2P state of the H+, K+-ATPase2018
- Author(s)
  Dubey Vikas、Han Minwoo、Kopec Wojciech、Solov’yov Ilia A.、Abe Kazuhiro、Khandelia Himanshu
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-018-30885-w
- Data Source
  KAKENHI-PROJECT-17H03653
[Journal Article] Crystal structures of the gastric proton pump2018
- Author(s)
  Abe Kazuhiro、Irie Katsumasa、Nakanishi Hanayo、Suzuki Hiroshi、Fujiyoshi Yoshinori
- Journal Title
  
  Nature
  
  Volume: 556 Issue: 7700 Pages: 214-218
- DOI
  10.1038/s41586-018-0003-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-17K17795, KAKENHI-PROJECT-17H03653
[Journal Article] The cryo-EM structure of gastric H+,K+-ATPase with bound BYK99, a high-affinity member of K+-competitive, imidazo[1,2-a]pyridine inhibitors2017
- Author(s)
  Abe Kazuhiro、Shimokawa Jun、Naito Mao、Munson Keith、Vagin Olga、Sachs George、Suzuki Hiroshi、Tani Kazutoshi、Fujiyoshi Yoshinori
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 6632-6632
- DOI
  10.1038/s41598-017-06698-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19347, KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-17H03653, KAKENHI-PROJECT-15H05641
[Journal Article] Two-dimensional crystallization of gastric H+,K+-ATPase for structural analysis by electron crystallography2016
- Author(s)
  Abe K.
- Journal Title
  
  Methods in Mol. Biol.
  
  Volume: 1377 Pages: 433-458
- DOI
  10.1007/978-1-4939-3179-8_39
- ISBN
  9781493931781, 9781493931798
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26711005
[Journal Article] Cryo-electron microscopy for structure analyses of membrane proteins in the lipid bilayer2016
- Author(s)
  Abe K. & Fujiyoshi Y.
- Journal Title
  
  Current Opinion in Structural Biology
  
  Volume: 39 Pages: 71-79
- DOI
  10.1016/j.sbi.2016.06.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26711005
[Journal Article] Isoration of H+,K+-ATPase-enriched membrane fraction from pig stomach2016
- Author(s)
  Abe K ., Olesen C.
- Journal Title
  
  Methods in Mol. Biol.
  
  Volume: 1377 Pages: 19-28
- DOI
  10.1007/978-1-4939-3179-8_4
- ISBN
  9781493931781, 9781493931798
- Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26711005
[Journal Article] Systematic comparison of molecular conformations of H+,K+-ATPase reveals an important contribution of the A-M2 linker for the luminal gating.2014
- Author(s)
  K. Abe, K. Tani and Y. Fujiyoshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 289 Issue: 44 Pages: 30590-30601
- DOI
  10.1074/jbc.m114.584623
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-22227004, KAKENHI-PROJECT-26440024, KAKENHI-PROJECT-26711005
[Journal Article] Carbon sandwich preparation preserves quality of two-dimensional crystals for cryo-electron microscopy2013
- Author(s)
  F. Yang, K. Abe, K. Tani and Y. Fujiyoshi
- Journal Title
  
  Microscopy
  
  Volume: 62 Pages: 597-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770147
[Journal Article] The four-transmembrane protein IP39 of Euglena forms strand by a trimeric unit repeat.2013
- Author(s)
  H. Suzuki, Y Ito, Y Yamazaki, K Mineta, M Uji, K. Abe, K. Tani, Y. Fujiyoshi and S. Tsukita.
- Journal Title
  
  Nature Commun.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22227004
[Journal Article] The four-transmembrane protein IP39 of Euglena forms strands by a trimeric unit repeat2013
- Author(s)
  Suzuki, H., Ito, Y., Yamazaki, Y., Mineta, K.,Uji, M., Abe, K., Tani, K., Fujiyoshi, Y. &Tsukita, S.
- Journal Title
  
  Nat. Commun.
  
  Volume: 4(10.1038/ncomms2731) Pages: 1766-1766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24870014
[Journal Article] Carbon sandwich preparation preserves quality of two-dimensional crystals for cryo-electron microscopy.2013
- Author(s)
  F. Yang, K. Abe, K. Tani and Y. Fujiyoshi
- Journal Title
  
  Microscopy
  
  Volume: 62 Issue: 6 Pages: 597-606
- DOI
  10.1093/jmicro/dft038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22227004, KAKENHI-PROJECT-24870014
[Journal Article] Strand formation by a trimeric unit repeat of four-transmembrane proteins in Euglena2013
- Author(s)
  H. Suzuki, Y. Ito, Y. Yamazaki, K. Mineta, M. Uji, K. Abe, K. Tani, Y. Fujiyoshi and S. Tsukita
- Journal Title
  
  Nat. Commun
  
  Volume: 4 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770147
[Journal Article] Carbon sandwich preparation preserves quality of two-dimensional crystals for cryo-electron microscopy2013
- Author(s)
  Yang, F., Abe, K. Tani, K. & Fujiyoshi, Y.
- Journal Title
  
  Microscopy (Oxf)
  
  Volume: 62(10.1093/jmicro/dft038) Pages: 597-606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24870014
[Journal Article] Cryo-EM structure of gastric H+,K+-ATPase with a single occupied cation-binding site.2012
- Author(s)
  Abe, K., Tani, K., Friedrich, T. & Fujiyoshi, Y.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 109 Pages: 18401-18406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24870014
[Journal Article] Cryo-EM structure of gastric H+,K+-ATPase with a single occupied cation binding site2012
- Author(s)
  Abe, K., Tani, K., Friedrich, T. & Fujiyoshi,Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A.
  
  Volume: 109(10.1073/pnas) Pages: 18401-18406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24870014
[Journal Article] Cryo-EM structure of gastric H+, K+-ATPase with a single occupied cation-binding site2012
- Author(s)
  K. Abe, K. Tani, T. Friedrich and Y. Fujiyoshi
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A.
  
  Volume: 109 Pages: 18401-18406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770147
[Journal Article] Cryo-EM structure of gastric H+,K+-ATPase with a single occupied cation-binding site.2012
- Author(s)
  K. Abe, K. Tani, T. Friedrich and Y. Fujiyoshi
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A.
  
  Volume: 109 Issue: 45 Pages: 18401-18406
- DOI
  10.1073/pnas.1212294109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22227004, KAKENHI-PROJECT-22770147
[Journal Article] Conformational rearrangement of gastric H^+,K^+-ATPase induced by an acid suppressant2011
- Author(s)
  K.Abe, K.Tani, Y.Fujiyoshi
- Journal Title
  
  Nature Commun.
  
  Volume: 2 Issue: 1
- DOI
  10.1038/ncomms1154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22227004
[Journal Article] Conformational rearrangement of gastric H^+, K^+-ATPase induced by an acid suppressant.2011
- Author(s)
  K.Abe
- Journal Title
  
  Nature Commun.
  
  Volume: 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22227004
[Journal Article] Conformational rearrangement of gastric H^+,K^+-ATPase induced by an acid suppressant.2011
- Author(s)
  K.Abe
- Journal Title
  
  Nat.Commun.
  
  Volume: 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770147
[Journal Article] Conformational rearrangement of gastric H^+, K^+-ATPase induced by an acid suppressant2011
- Author(s)
  K. Abe, K. Tani and Y. Fujiyoshi
- Journal Title
  
  Nat. Commun
  
  Volume: 2 Pages: 155-155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770147
[Journal Article] Structural and functional characterization of H^+,K^+-ATPase with bound fluorinated phosphate analogs.2010
- Author(s)
  K.Abe
- Journal Title
  
  J.Struct.Biol.
  
  Volume: 170 Pages: 60-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770147
[Journal Article] Structural and functional characterization of H^+, K^+-ATPase with bound fluorinated phosphate analogs2010
- Author(s)
  K. Abe, K. Tani and Y. Fujiyoshi
- Journal Title
  
  J. Struct. Biol
  
  Volume: 170 Pages: 60-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22770147
[Presentation] ナトリウムポンプのつくりかた2023
- Author(s)
  阿部一啓
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02426
[Presentation] How to make a Na+ pump2022
- Author(s)
  Kazuhiro Abe
- Organizer
  The 60th Annual Meeting of the Biophysical Society of Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02426
[Presentation] Structural Physiology of the Gastric Proton pump and the Lipid Flippase2022
- Author(s)
  Kazuhiro Abe
- Organizer
  P-Type ATPases in Health and Disease
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02426
[Presentation] 細胞膜フリッパーゼATP11Cの構造機能解析2020
- Author(s)
  阿部一啓
- Organizer
  第93回日本生化学会
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] Crystal structures of the gastric proton pump - molecular basis for the binding of acid suppressants, H+-extrusion and K+-counter-transport2020
- Author(s)
  Kazuhiro Abe
- Organizer
  日本薬学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] 『細胞死を司るポンプ』脂質フリッパーゼATP11Cの結晶構造とCryoEM構造2020
- Author(s)
  阿部一啓
- Organizer
  日本生体エネルギー研究会
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] Structural basis of the proton extrusion mechanism of the gastric proton pump2020
- Author(s)
  Kazuhiro Abe
- Organizer
  第97回日本生理学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] X線結晶学とクライオ電顕で得られた構造情報の上手な活用法　～胃プロトンポンプの構造解析を例として～2019
- Author(s)
  阿部一啓
- Organizer
  2019年度生理研研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] Structural basis for the H+-extrusion and the K+-occlusion of the gastric proton pump2019
- Author(s)
  Kazuhiro Abe
- Organizer
  Society of General Physiology /SOBLA 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] Crystal structure of the gastric proton pump2019
- Author(s)
  Kazuhiro Abe
- Organizer
  World Laureates Forum 2nd conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] 胃プロトンポンプの輸送機構に対する構造基盤2019
- Author(s)
  Kazuhiro Abe
- Organizer
  生物物理第57回年会台湾‐日本　二国間シンポジウム：X線結晶構造解析とクライオ電顕2019
- Invited
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] Molecular mechanisms for the drug binding, H+-extrusion and the K+ counter-transport2019
- Author(s)
  Kazuhiro Abe
- Organizer
  Academia Sinica IBC seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] 胃の強酸性化の分子メカニズム ‐胃プロトンポンプの結晶構造解析2018
- Author(s)
  阿部一啓
- Organizer
  生体エネルギー研究会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] Crystal structures of the gastric proton pump2018
- Author(s)
  Abe K
- Organizer
  AsCA
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] 胃プロトンポンプの結晶構造によって明らかになったH+排出機構2018
- Author(s)
  阿部一啓
- Organizer
  大阪大学蛋白質研究所セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] Structural basis for the H+ extrusion and the transport stoichiometry of the gastric proton pump2018
- Author(s)
  Abe K
- Organizer
  Frontiers in P-type ATPase Research 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] 胃の強酸性化の秘密2018
- Author(s)
  阿部一啓
- Organizer
  創薬等ライフサイエンス研究支援基盤事業　平成30年度BINDS公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] Structural and functional analysis of gastric proton pump and acid suppressants2017
- Author(s)
  Abe K.
- Organizer
  ConBio2017
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] Structural and functional analysis of gastric H+,K+-ATPase2017
- Author(s)
  Abe K.
- Organizer
  The 15th international conference on Na,K-ATPase and related transport ATPases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03653
[Presentation] 胃プロトンポンプの構造生理学2016
- Author(s)
  阿部一啓
- Organizer
  千里ライフサイエンスセミナーＫ２　トランスポーターと創薬～構造と病態からのアプローチ～
- Place of Presentation
  千里ライフサイエンスセンター　大阪
- Invited
- Data Source
  KAKENHI-PROJECT-26711005
[Presentation] Electron crystallographic analysis of gastric proton pump2016
- Author(s)
  Abe K.
- Organizer
  IPR Seminar "Introduction and overview of cryo-electron microscopy"
- Place of Presentation
  Osaka
- Year and Date
  2016-02-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26711005
[Presentation] Structural physiology of gastric proton pump2015
- Author(s)
  Abe K.
- Organizer
  Denmark-Japan Joint Workshop on Ion Transport Proteins
- Place of Presentation
  Yokohama
- Year and Date
  2015-09-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26711005
[Presentation] 胃H+,K+-ATPaseの胃酸抑制剤結合状態についての考察2015
- Author(s)
  阿部一啓
- Organizer
  日本生体エネルギー研究会　第４１回　討論会
- Place of Presentation
  東京
- Year and Date
  2015-12-22
- Data Source
  KAKENHI-PROJECT-26711005
[Presentation] Antagonist-bound structure of gastric proton pump2015
- Author(s)
  Abe K.
- Organizer
  第５３回日本生物物理学会年会
- Place of Presentation
  金沢
- Year and Date
  2015-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-26711005
[Presentation] 胃プロトンポンプ　H+,K+-ATPaseの構造生理学2014
- Author(s)
  阿部一啓
- Organizer
  九州地区　生理薬理系研究会
- Place of Presentation
  福岡医科大学
- Year and Date
  2014-12-09
- Invited
- Data Source
  KAKENHI-PROJECT-26711005
[Presentation] Unique properties and conserved conformational changes found in gastric H+,K+-ATPase2013
- Author(s)
  K. Abe
- Organizer
  Nagoya Symposium
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22770147
[Presentation] Unique properties and conserved conformational changes found in gastric H+,K+-ATPase2013
- Author(s)
  Kazuhiro Abe
- Organizer
  Nagoya Symposium
- Place of Presentation
  Nagoya University
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] 胃プロトンポンプの極低温電子顕微鏡による構造解析2013
- Author(s)
  阿部一啓
- Organizer
  大阪大学タンパク質研究所セミナー　第4回神経科学と構造生物学の融合研究会
- Place of Presentation
  岡崎
- Invited
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] Biochemical and electron crystallographic studies of gastric proton pump2013
- Author(s)
  Abe, K.
- Organizer
  The 86th Annual Meeting of the Japanese Biochemical Society
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] Biochemical and Electron crystallographic Studies of Gastric Proton Pump2013
- Author(s)
  Abe K.
- Organizer
  The 86th Annual Meeting of the Japanese Biochemical Society,
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] 胃プロトンポンプの生化学と電子線結晶構造解析2013
- Author(s)
  阿部一啓
- Organizer
  日本生化学会平成25年度奨励賞受賞講演
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] 胃プロトンポンプの生化学と電子線結晶構造解析2013
- Author(s)
  阿部一啓
- Organizer
  日本生化学会平成25 年度奨励賞受賞講演
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] 胃プロトンポンプの極低温電子顕微鏡による構造解析2013
- Author(s)
  阿部一啓
- Organizer
  大阪大学タンパク質研究所セミナー第4回神経科学と構造生物学の融合研究会
- Place of Presentation
  岡崎
- Invited
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] 電子顕微鏡のイメージから膜タンパク質の立体構造を再構成する2013
- Author(s)
  阿部一啓
- Organizer
  第23回分析化学講習会愛知地区講演会
- Place of Presentation
  名古屋大学
- Invited
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] Strand-forming polymerization of four-transmembrane proteins in Euglena through intermolecular interactions of tandem trimers2013
- Author(s)
  伊藤泰行, 鈴木博視, 山崎裕自, 峯田克彦, 氏昌未, 阿部一啓, 谷一寿, 藤吉好則, 月田早智子
- Organizer
  第62回日本細胞生物学会大会
- Place of Presentation
  ウィンクあいち
- Data Source
  KAKENHI-PROJECT-22770147
[Presentation] Unique properties and conserved conformational changes found in gastric H+,K+-ATPase2013
- Author(s)
  Abe, K
- Organizer
  Nagoya Symposium
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] Cryo-EM structures of gastric proton pump2013
- Author(s)
  Kazuhiro Abe
- Organizer
  FAOBMB mini symposium
- Place of Presentation
  Morioka, Iwate
- Invited
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] 電子顕微鏡のイメージから膜タンパク質の立体構造を再構成する2013
- Author(s)
  阿部一啓
- Organizer
  第23回分析化学講習会　愛知地区講演会
- Place of Presentation
  名古屋大学
- Invited
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] Cryo-EM structures of gastric proton pump.2013
- Author(s)
  Abe K.
- Organizer
  FAOBMB Mini-symposium
- Place of Presentation
  Iwate Medical University
- Invited
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] Cryo-EM structure of gastric protonpump2013
- Author(s)
  Abe, K
- Organizer
  FAOBMB mini symposium
- Place of Presentation
  Morioka, Iwate (Invited)
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] 対向輸送カチオンを一つだけ結合した胃H+,K+-ATPase の8Å 分解能での立体構造2012
- Author(s)
  阿部一啓
- Organizer
  日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] 電子線結晶学による胃プロトンポンプの立体構造解析2012
- Author(s)
  阿部一啓
- Organizer
  日本生体エネルギー研究会
- Place of Presentation
  岡山大学
- Invited
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] 胃プロトンポンプの構造生理学
- Author(s)
  阿部一啓
- Organizer
  第9回トランスポーター研究会
- Place of Presentation
  名古屋市立大学
- Year and Date
  2014-06-14 – 2014-06-15
- Invited
- Data Source
  KAKENHI-PROJECT-26711005
[Presentation] 電子線結晶学による胃プロトンポンプの立体構造解析
- Author(s)
  阿部　一啓
- Organizer
  日本生体エネルギー研究会
- Place of Presentation
  岡山大学
- Invited
- Data Source
  KAKENHI-PROJECT-24870014
[Presentation] Structural and biochemical analysis of gastric H+,K+-ATPase in E2P-analogue conformations.
- Author(s)
  Abe K.
- Organizer
  14th International Conference Na,K-ATPase and related ATPases: Structure, mechanism, cell biology, health and diseas
- Place of Presentation
  Lunteren, Netherlands
- Year and Date
  2014-08-30 – 2014-09-05
- Invited
- Data Source
  KAKENHI-PROJECT-26711005
[Presentation] Systematic comparison of the molecular conformation of gastric H+,K+-ATPase in E2P state analogs
- Author(s)
  阿部一啓
- Organizer
  日本生体エネルギー研究会　第40回討論会
- Place of Presentation
  愛媛大学
- Year and Date
  2014-12-11 – 2014-12-13
- Invited
- Data Source
  KAKENHI-PROJECT-26711005
[Presentation] Electron crystallographic analysis of gastric proton pump.
- Author(s)
  Abe K.
- Organizer
  JEM Next-Generation Microscopic Science, Opening Symposium “Toward Cross-disciplinary researches between Life and Material Sciences”
- Place of Presentation
  Awaji
- Year and Date
  2014-11-03 – 2014-11-04
- Invited
- Data Source
  KAKENHI-PROJECT-26711005
[Presentation] 対向輸送カチオンを一つだけ結合した胃H+,K+-ATPaseの8Å分解能での立体構造
- Author(s)
  阿部　一啓
- Organizer
  日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24870014
[]

1. FUJIYOSHI Yoshinori (80142298)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
2. OHSHIMA Atsunori (80456847)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. TANI Kazutoshi (20541204)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. 入江克雅 (20415087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. NISHIZAWA Tomohiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 長田重一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 廣田毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 栗栖源嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 川本晃大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 慈幸千真理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ABE Kazuhiro 阿部 一啓

Research Projects

Research Products

Co-Researchers

物質不均衡分布形成原理の理解を目指した能動輸送体P型ATPaseの構造機能生理学Principal Investigator

Principal Investigator

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Strucutral physiology of P-type ATPasesPrincipal Investigator

Principal Investigator

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Review Section

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Structural physiology of the gastric proton pumpPrincipal Investigator

Principal Investigator

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Research Institution

Studies in structural physiology of channels

Principal Investigator

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Investigation for the mechanism of the gastric proton pump that generates the steepest cation gradientPrincipal Investigator

Principal Investigator

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Unique mechanisms of gastric proton pump revealed byPrincipal Investigator

Principal Investigator

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Structural and functional study of membrane proteins based on electron crystallography

Principal Investigator

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Research Institution

Electron crystallographic analysis of two dimensional crystals of membrane proteins maintaining proton gradient

Principal Investigator

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Research Institution

[Journal Article] Specific protonation of acidic residues confers K+ selectivity to the gastric proton pump2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deep learning driven de novo drug design based on gastric proton pump structures2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An unusual conformation from Na+-sensitive non-gastric proton pump mutants reveals molecular mechanisms of cooperative Na+-binding2023

Author(s)

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DOI

Data Source

[Journal Article] A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities2023

Author(s)

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DOI

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[Journal Article] Three structures of PSI-LHCI from Chlamydomonas reinhardtii suggest a resting state re-activated by ferredoxin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure and function of H+/K+ pump mutants reveal Na+/K+ pump mechanisms2022

Author(s)

Journal Title

ABE Kazuhiro 阿部一啓