Irie Katsumasa 入江克雅

Researcher Number	20415087
Other IDs	https://orcid.org/0000-0002-8178-1552
Affiliation (Current)	2025: 和歌山県立医科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 和歌山県立医科大学, 薬学部, 准教授 2015 – 2020: 名古屋大学, 細胞生理学研究センター, 助教
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Basic Section 55050:Anesthesiology-related / General physiology Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological Sciences / Biophysics
Keywords	Principal Investigator 構造解析 / イオンチャネル / 分子動力学計算 / 電気生理 / 電気生理学 / イオン選択性 / 構造機能相関 / ナトリウムチャネル / 局所麻酔剤 / 構造生物学 … More / 局所麻酔薬 / 構造活性相関 / 構造生理学 / X線結晶構造解析 … More Except Principal Investigator 高速原子間力顕微鏡 / 電位依存性ナトリウムチャネル / 神経情報伝達 / 生物発光 / 神経活動 / TJ-MAPs / TJ-ストランド / アピカル細胞骨格 / TJ-アピカル複合体 / 細胞間バリア / TJストランド / クライオ電顕 / アピカル骨格 / TJMAP / 液-液相分離（LLPS） / アピカル膜 / クライオ電顕トモグラフィー / 細胞骨格 / 上皮細胞 / クローディン / タイトジャンクション / 上皮バリア / 電子線結晶学 / 膜タンパク質の生理機能 / 単粒子解析法 / 構造生物学 / 結晶学 / 単粒子解析 / 膜タンパク質 / チャネル / 構造生理学 / クライオ電子顕微鏡 Less

The master of ion selectivity of ion channelsPrincipal Investigator
- Principal Investigator
  
  入江克雅
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Wakayama Medical University
高速原子間力顕微鏡による電位依存性Na+チャネルの電位依存的活性調節機構の解明
- Principal Investigator
  
  角野歩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kanazawa University
Creation of a luminescence protein sensing electric potential
- Principal Investigator
  
  Nakatsu Toru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Wakayama Medical University
The structural analysis of the binding inhibition mechanism of local anesthetics using cryo-electron microscopy.Principal Investigator
- Principal Investigator
  
  Irie Katsumasa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Wakayama Medical University
  Nagoya University
Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers
- Principal Investigator
  
  月田早智子
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Teikyo University
  Osaka University
Structural and functional analysis of sodium selective permeation of voltage dependent sodium channelPrincipal Investigator
- Principal Investigator
  
  Irie Katsumasa
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Nagoya University
Studies in structural physiology of channels
- Principal Investigator
  
  FUJIYOSHI Yoshinori
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biophysics
- Research Institution
  Tokyo Medical and Dental University
  Nagoya University

All 2023 2022 2021 2020 2019 2018 2017 2016 Other

All Journal Article Presentation Other

[Journal Article] The structural basis of the divalent cation blocking on tetrameric cation channel2023
- Author(s)
  Irie Katsumasa、Oda Yoshinori、Sumikama Takashi、Oshima Atsunori、Fujiyoshi Yoshinori
- Journal Title
  
  Research Square
  
  Volume: -
- DOI
  10.21203/rs.3.rs-2252854/v1
- Data Source
  KAKENHI-PROJECT-20K09193
[Journal Article] Voltage sensors of a Na+ channel dissociate from the pore domain and form inter-channel dimers in the resting state2023
- Author(s)
  Sumino Ayumi、Sumikama Takashi、Shibata Mikihiro、Irie Katsumasa
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 7835-7835
- DOI
  10.1038/s41467-023-43347-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19290, KAKENHI-PROJECT-21H01771
[Journal Article] Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human α2δ1, a Voltage-Gated Calcium Channel Subunit2023
- Author(s)
  Kozai Daisuke、Numoto Nobutaka、Nishikawa Kouki、Kamegawa Akiko、Kawasaki Shohei、Hiroaki Yoko、Irie Katsumasa、Oshima Atsunori、Hanzawa Hiroyuki、Shimada Kousei、Kitano Yutaka、Fujiyoshi Yoshinori
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 435 Issue: 10 Pages: 168049-168049
- DOI
  10.1016/j.jmb.2023.168049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00451, KAKENHI-PROJECT-20K09193, KAKENHI-PROJECT-19H03165
[Journal Article] 細菌の祖先型イオンチャネルから探る、普遍的なカルシウム選択機構2021
- Author(s)
  下村　拓史・入江　克雅
- Journal Title
  
  生物物理
  
  Volume: 未定
- NAID
  130008068996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09193
[Journal Article] Selectivity Determinant of Ancestor-like Prokaryotic Calcium Channel2021
- Author(s)
  SHIMOMURA Takushi、IRIE Katsumasa
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 61 Issue: 4 Pages: 223-226
- DOI
  10.2142/biophys.61.223
- NAID
  130008068996
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09193
[Journal Article] The insights into calcium ion selectivity provided by ancestral prokaryotic ion channels2021
- Author(s)
  Irie Katsumasa
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 18 Issue: 0 Pages: 274-283
- DOI
  10.2142/biophysico.bppb-v18.033
- NAID
  130008124789
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09193
[Journal Article] Gastric proton pump with two occluded K+ engineered with sodium pump-mimetic mutations2021
- Author(s)
  Abe Kazuhiro、Yamamoto Kenta、Irie Katsumasa、Nishizawa Tomohiro、Oshima Atsunori
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 5709-5709
- DOI
  10.1038/s41467-021-26024-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03216, KAKENHI-PROJECT-20K09193, KAKENHI-PROJECT-21K19215, KAKENHI-PROJECT-21H02426
[Journal Article] A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence2020
- Author(s)
  Shimomura Takushi、Yonekawa Yoshiki、Nagura Hitoshi、Tateyama Michihiro、Fujiyoshi Yoshinori、Irie Katsumasa
- Journal Title
  
  eLife
  
  Volume: 9 Pages: 1-21
- DOI
  10.7554/elife.52828
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-17K08557, KAKENHI-PROJECT-17K17795
[Journal Article] A single K+-binding site in the crystal structure of the gastric proton pump2019
- Author(s)
  Yamamoto Kenta、Dubey Vikas、Irie Katsumasa、Nakanishi Hanayo、Khandelia Himanshu、Fujiyoshi Yoshinori、Abe Kazuhiro
- Journal Title
  
  eLife
  
  Volume: 8
- DOI
  10.7554/elife.47701
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-17H03653, KAKENHI-PROJECT-17K17795
[Journal Article] Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression2019
- Author(s)
  Kamiya Atsunori、Hayama Yohsuke、Kato Shigeki、Shimomura Akihiko、Shimomura Takushi、Irie Katsumasa、Kaneko Ryosuke、Yanagawa Yuchio、Kobayashi Kazuto、Ochiya Takahiro
- Journal Title
  
  Nature Neuroscience
  
  Volume: 22 Issue: 8 Pages: 1289-1305
- DOI
  10.1038/s41593-019-0430-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22474, KAKENHI-PROJECT-18K16408, KAKENHI-PUBLICLY-18H04707, KAKENHI-PUBLICLY-19H04895, KAKENHI-PROJECT-15H05791, KAKENHI-PROJECT-17H04365, KAKENHI-PROJECT-18K19950, KAKENHI-PROJECT-17K17795, KAKENHI-PROJECT-15KK0331
[Journal Article] Enhancement of the thermostability of mouse claudin-3 on complex formation with the carboxyl-terminal region of Clostridium perfringens enterotoxin improves crystal quality2018
- Author(s)
  Nakamura Shun、Fujiyoshi Yoshinori、Irie Katsumasa
- Journal Title
  
  Acta Crystallographica Section F Structural Biology Communications
  
  Volume: 74 Issue: 3 Pages: 150-155
- DOI
  10.1107/s2053230x18002005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K17795
[Journal Article] Optimized expression and purification of NavAb provide the structural insight into the voltage dependence2018
- Author(s)
  Irie Katsumasa、Haga Yukari、Shimomura Takushi、Fujiyoshi Yoshinori
- Journal Title
  
  FEBS Letters
  
  Volume: 592 Issue: 2 Pages: 274-283
- DOI
  10.1002/1873-3468.12955
- NAID
  120006473551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K17795
[Journal Article] Crystal structures of the gastric proton pump2018
- Author(s)
  Abe Kazuhiro、Irie Katsumasa、Nakanishi Hanayo、Suzuki Hiroshi、Fujiyoshi Yoshinori
- Journal Title
  
  Nature
  
  Volume: 556 Issue: 7700 Pages: 214-218
- DOI
  10.1038/s41586-018-0003-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05775, KAKENHI-PROJECT-17K17795, KAKENHI-PROJECT-17H03653
[Journal Article] Molecular determinants of prokaryotic voltage-gated sodium channels for recognition of local anesthetics.2016
- Author(s)
  T. Shimomura, K. Irie and Y. Fujiyoshi
- Journal Title
  
  FEBS Journal
  
  Volume: 283 Issue: 15 Pages: 2881-2895
- DOI
  10.1111/febs.13776
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05775
[Presentation] 結晶構造と分子動力学計算によるイオンチャネルにおける二価カチオンの阻害機構の解析2023
- Author(s)
  入江克雅
- Organizer
  日本薬学会第１４３年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09193
[Presentation] 原核生物由来ナトリウムチャネルに創出された二価カチオンによる電流阻害の分子機構2023
- Author(s)
  入江克雅
- Organizer
  日本生理学会第100回記念大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09193
[Presentation] Dissociation and inter-channel dimerization of voltage-sensor domains (VSD) of voltage-gated Na+ channel in the resting state2023
- Author(s)
  Ayumi Sumino, Takashi Sumikama, Leonardo Puppulin, Mikihiro Shibata, Katsumasa Irie
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-22K19290
[Presentation] 細菌のカルシウムチャネルが示すカルシウム選択的なイオン透過機構2022
- Author(s)
  入江克雅
- Organizer
  第95回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09193
[Presentation] 四量体型イオンチャネルにおける二価カチオンによる阻害機構の構造基盤の解析2022
- Author(s)
  入江克雅
- Organizer
  生理研研究会 ”構造情報を基盤とした膜機能分子の生理機能理解に向けて”
- Data Source
  KAKENHI-PROJECT-20K09193
[Presentation] The generation of the divalent cation blocking on tetrameric sodium channel2021
- Author(s)
  Katsumasa Irie, Yoshinori Oda and Atsunori Oshima
- Organizer
  第５９回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-20K09193
[Presentation] 細菌由来のイオンチャネルに見いだされたカルシウムの選択的透過と機能阻害2021
- Author(s)
  入江克雅
- Organizer
  生理研研究会”構造情報を基盤とした膜機能分子の生理機能理解に向けて”
- Invited
- Data Source
  KAKENHI-PROJECT-20K09193
[Presentation] 天然の原核生物由来カルシウムチャネルにおけるイオン透過選択性の進化とその決定残基の同定2020
- Author(s)
  入江克雅, 下村拓史, 米川佳樹, 名倉仁, 立山充博, 藤吉好則
- Organizer
  第58回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-20K09193
[Presentation] 新しい選択性フィルター配列を有する原核生物由来膜電位感受性カルシウムチャネルの同定と機能解析2019
- Author(s)
  下村拓史、米川佳樹、名倉仁、立山充博、藤吉好則、〇入江克雅
- Organizer
  "生理学研究所研究会「イオンチャネルと生体膜のダイナミズム：構造生物学の先にあるもの」"
- Data Source
  KAKENHI-PROJECT-17K17795
[Presentation] Tutorial for physiologists:“Practical Approaches to Protein Structural Information”2019
- Author(s)
  Katsumasa Irie
- Organizer
  9th FAOPS congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17795
[Presentation] Claudin-3の結晶構造が明らかにするタイトジャンクション形態の決定要素2019
- Author(s)
  中村駿, 入江克雅, 田中啓雄, 田村淳, 月田早智子, 藤吉好則
- Organizer
  第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] Unexpected primary sequence of the selectivity filter of endogenous prokaryotic voltage-gated calcium channel2018
- Author(s)
  Katsumasa Irie, Takushi Shimomura, Toshiki Yonekawa, Hitoshi Nagura, and Yoshinori Fujiyoshi
- Organizer
  The 49th NIPS International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17795
[Presentation] 複数の変異体を用いた原核生物由来ナトリウムチャネルの選択性フィルターの構造解析2018
- Author(s)
  入江克雅、中村駿、藤吉好則
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K17795
[Presentation] 構造生理学的アプローチによるナトリウムチャネルのイオン透過機構の解析2018
- Author(s)
  入江　克雅
- Organizer
  蛋白研セミナー：構造情報に基づいた膜イオン輸送タンパク質の生理機能の解明に向けて
- Invited
- Data Source
  KAKENHI-PROJECT-17K17795
[Presentation] Asymmetric interaction of permeating cation and local anesthetic with homo-tetrameric sodium channel2018
- Author(s)
  入江克雅
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17K17795
[Presentation] ナトリウムイオン選択的透過機構の解明を目指したNavAb変異体の構造解析2017
- Author(s)
  入江克雅
- Organizer
  第２回イオンチャネル研究会～チャネル七夕～
- Data Source
  KAKENHI-PROJECT-17K17795
[Presentation] 「四量体型ナトリウムチャネルの構造機能研究とその応用」2017
- Author(s)
  入江克雅
- Organizer
  第2回　医薬系3部局交流シンポジウム
- Data Source
  KAKENHI-PROJECT-17K17795
[Presentation] Characterization of prokaryotic voltage-gated calcium channel2017
- Author(s)
  Katsumasa Irie, Takushi Shimomura, Toshiki Yonekawa & Yoshinori Fujiyoshi
- Organizer
  第55回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17K17795
[Presentation] 四量体型ナトリウムチャネルにみられる透過イオンや阻害剤との非対称な相互作用2017
- Author(s)
  入江克雅
- Organizer
  平成29年度生理学研究所研究会「膜システムの機能的・構造的統合」
- Data Source
  KAKENHI-PROJECT-17K17795
[]

1. FUJIYOSHI Yoshinori (80142298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. Nakatsu Toru (50293949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 大嶋篤典 (80456847)

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4. 谷一寿 (20541204)

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5. 阿部一啓 (60596188)

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6. 月田早智子 (00188517)

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7. Danev Radostin (50415931)

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8. 中村駿 (80882779)

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9. 後藤慎平 (50747219)

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10. 近藤玄 (40243258)

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11. 田村淳 (00362525)

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12. 田中啓雄 (70795905)

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13. 柏原宏香 (20966692)

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14. 足澤悦子 (00446262)

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15. 足立誠 (30335244)

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16. 鈴木貴 (40114516)

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18. 角野歩 (80717140)

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19. 炭竈享司 (30579412)

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20. NISHIZAWA Tomohiro

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21. NUMOTO Nobutaka

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22. 亀川亜希子

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23. 小林和人

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Irie Katsumasa 入江 克雅

Research Projects

Research Products

Co-Researchers

The master of ion selectivity of ion channelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

高速原子間力顕微鏡による電位依存性Na+チャネルの電位依存的活性調節機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Creation of a luminescence protein sensing electric potential

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The structural analysis of the binding inhibition mechanism of local anesthetics using cryo-electron microscopy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural and functional analysis of sodium selective permeation of voltage dependent sodium channelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies in structural physiology of channels

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The structural basis of the divalent cation blocking on tetrameric cation channel2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Voltage sensors of a Na+ channel dissociate from the pore domain and form inter-channel dimers in the resting state2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human α2δ1, a Voltage-Gated Calcium Channel Subunit2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 細菌の祖先型イオンチャネルから探る、普遍的なカルシウム選択機構2021

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Selectivity Determinant of Ancestor-like Prokaryotic Calcium Channel2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] The insights into calcium ion selectivity provided by ancestral prokaryotic ion channels2021

Author(s)

Journal Title

DOI

NAID

ISSN

Irie Katsumasa 入江克雅

[Presentation] 結晶構造と分子動力学計算によるイオンチャネルにおける二価カチオンの阻害機構の解析2023

[Presentation] 原核生物由来ナトリウムチャネルに創出された二価カチオンによる電流阻害の分子機構2023

[Presentation] 四量体型イオンチャネルにおける二価カチオンによる阻害機構の構造基盤の解析2022