Yano Tomoki 矢野智樹

… Alternative Names

YANO Tomoki 矢野智樹

Tomoki Yano 矢野智樹

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Researcher Number	20546121
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 講師
Affiliation (based on the past Project Information) *help	2024: 大阪大学, 医学系研究科, 助教 2022 – 2024: 慶應義塾大学, 医学部(信濃町), 特任講師 2018 – 2020: 大阪大学, 医学系研究科, 助教 2014 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Basic Section 44010:Cell biology-related / Cell biology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 細胞間接着 / 細胞骨格 / タイトジャンクション / NAFLD / NASH / 形態形成 / 分化機能 / 肝オルガノイド / オルガノイド / p38 … More / YAP / PTEN / vinculin / AMPK / cingulin / 細胞外ストレス / 上皮細胞 / AMP活性プロテインキナーゼ / アドヘレンスジャンクション / AMP活性化プロテインキナーゼ … More Except Principal Investigator TJ-MAPs / TJ-ストランド / アピカル細胞骨格 / TJ-アピカル複合体 / 細胞間バリア / TJストランド / クライオ電顕 / アピカル骨格 / TJMAP / 液-液相分離（LLPS） / アピカル膜 / クライオ電顕トモグラフィー / バリア病 / 細胞骨格 / 上皮細胞 / クローディン / タイトジャンクション / 上皮バリア Less

Exploration of Causative Genes for NAFLD and NASH Using Human Liver Organoids and Development of Potential TherapiesPrincipal Investigator
- Principal Investigator
  
  YANO Tomoki
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Keio University
Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers
- Principal Investigator
  
  Tsukita Sachiko
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Teikyo University
  Osaka University
The Elucidation of tumorigenesis mechanisms through signal transduction starting from tight junction.Principal Investigator
- Principal Investigator
  
  Yano Tomoki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Osaka University
AMP-activated protein kinase regulates the function of tight junction.Principal Investigator
- Principal Investigator
  
  Tomoki Yano
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University

All 2025 2024 2023 2022 2021 2020 2019 2018 2016 2015

All Journal Article Presentation Book Patent

[Book] Make Life Visible (Apical Cytoskeletons help define the barrier functions of epithelial cell sheets in biological systems.)2019
- Author(s)
  Tsukita, S., Yano,T., and Herawati, E.
- Total Pages
  292
- Publisher
  Springer Open
- ISBN
  9811379106
- Data Source
  KAKENHI-PROJECT-19H05468
[Journal Article] Generation of human adult hepatocyte organoids with metabolic functions2025
- Author(s)
  Igarashi Ryo、Oda Mayumi、Okada Ryo、Yano Tomoki、Takahashi Sirirat、Pastuhov Strahil、Matano Mami、Masuda Norio、Togasaki Kazuhiro、Ohta Yuki、Sato Saeko、Hishiki Takako、Suematsu Makoto、Itoh Manabu、Fujii Masayuki、Sato Toshiro
- Journal Title
  
  Nature
  
  Volume: - Issue: 8065 Pages: 1-10
- DOI
  10.1038/s41586-025-08861-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H04995, KAKENHI-PROJECT-21K05294, KAKENHI-PROJECT-22K07028, KAKENHI-PROJECT-23K27677, KAKENHI-PROJECT-23K05742, KAKENHI-PROJECT-24K08642
[Journal Article] Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons2024
- Author(s)
  Shiratsuchi Gen、Konishi Satoshi、Yano Tomoki、Yanagihashi Yuichi、Nakayama Shogo、Katsuno Tatsuya、Kashihara Hiroka、Tanaka Hiroo、Tsukita Kazuto、Suzuki Koya、Herawati Elisa、Watanabe Hitomi、Hirai Toyohiro、Yagi Takeshi、Kondoh Gen、Gotoh Shimpei、Tamura Atsushi、Tsukita Sachiko
- Journal Title
  
  EMBO Reports
  
  Volume: 25 Issue: 3 Pages: 1176-1207
- DOI
  10.1038/s44319-024-00066-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H04016, KAKENHI-PROJECT-19H05468, KAKENHI-PUBLICLY-22H05498, KAKENHI-PROJECT-23H00390, KAKENHI-PUBLICLY-24H01237, KAKENHI-PROJECT-21K09629
[Journal Article] Phase separation of an actin nucleator by junctional microtubules regulates epithelial function2023
- Author(s)
  Tsukita Kazuto、Kitamata Manabu、Kashihara Hiroka、Yano Tomoki、Fujiwara Ikuko、Day Timothy F.、Katsuno Tatsuya、Kim Jaewon、Takenaga Fumiko、Tanaka Hiroo、Park Sungsu、Miyata Makoto、Watanabe Hitomi、Kondoh Gen、Takahashi Ryosuke、Tamura Atsushi、Tsukita Sachiko
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 7
- DOI
  10.1126/sciadv.adf6358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03453, KAKENHI-PROJECT-21K09629, KAKENHI-PROJECT-21K15092, KAKENHI-PROJECT-19H05468
[Journal Article] Planar cell polarity induces local microtubule bundling for coordinated ciliary beating2021
- Author(s)
  Nakayama Shogo、Yano Tomoki、Namba Toshinori、Konishi Satoshi、Takagishi Maki、Herawati Elisa、Nishida Tomoki、Imoto Yasuo、Ishihara Shuji、Takahashi Masahide、Furuta Ken’ya、Oiwa Kazuhiro、Tamura Atsushi、Tsukita Sachiko
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 220 Issue: 7
- DOI
  10.1083/jcb.202010034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H05468, KAKENHI-PROJECT-19H03453, KAKENHI-PLANNED-18H05420
[Journal Article] A microtubule‐LUZP1 association around tight junction promotes epithelial cell apical constriction2020
- Author(s)
  Yano Tomoki、Tsukita Kazuto、Kanoh Hatsuho、Nakayama Shogo、Kashihara Hiroka、Mizuno Tomoaki、Tanaka Hiroo、Matsui Takeshi、Goto Yuhei、Komatsubara Akira、Aoki Kazuhiro、Takahashi Ryosuke、Tamura Atsushi、Tsukita Sachiko
- Journal Title
  
  The EMBO Journal
  
  Volume: 40 Issue: 2
- DOI
  10.15252/embj.2020104712
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16050, KAKENHI-PLANNED-19H05798, KAKENHI-PROJECT-18H02444, KAKENHI-PROJECT-19H03453, KAKENHI-PROJECT-19K16126, KAKENHI-PROJECT-19H05468, KAKENHI-ORGANIZER-19H05794, KAKENHI-PROJECT-21K15092
[Journal Article] Reciprocal Association between the Apical Junctional Complex and AMPK: A Promising Therapeutic Target for Epithelial/Endothelial Barrier Function?2019
- Author(s)
  Tsukita, K., Yano, T., Tamura, A., and Tsukita, S.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Issue: 23 Pages: 6012-6012
- DOI
  10.3390/ijms20236012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14696, KAKENHI-PROJECT-18H03999, KAKENHI-PROJECT-16H05121, KAKENHI-PROJECT-19H05468, KAKENHI-PROJECT-19H03453
[Journal Article] Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions.2019
- Author(s)
  Konishi S, Yano T, Tanaka H, Mizuno T, Kanoh H, Tsukita K, Namba T, Tamura A, Yonemura S, Gotoh S, Matsumoto H, Hirai T, Tsukita S.
- Journal Title
  
  Life Sci Alliance
  
  Volume: 2 Issue: 4 Pages: e201900414-e201900414
- DOI
  10.26508/lsa.201900414
- NAID
  120007144472
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08649, KAKENHI-PROJECT-19K16126, KAKENHI-PROJECT-18H03999, KAKENHI-PROJECT-18H02617, KAKENHI-PROJECT-18K14696, KAKENHI-PROJECT-16H05121, KAKENHI-PROJECT-19H05468, KAKENHI-PROJECT-19H03453
[Journal Article] AMPK-dependent phosphorylation of cingulin reversibly regulates its binding to actin filaments and microtubules2018
- Author(s)
  Tomoki Yano, Takayuki Torisawa, Kazuhiro Oiwa & Sachiko Tsukita
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 15550-15550
- DOI
  10.1038/s41598-018-33418-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14696, KAKENHI-PROJECT-18H03999
[Patent] 細胞外基質の非存在下でオルガノイドを培養するための薬剤2022
- Inventor(s)
  佐藤俊朗　矢野智樹
- Industrial Property Rights Holder
  佐藤俊朗　矢野智樹
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-153698
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-22K07028
[Presentation] 多繊毛協調運動の確立過程のライブイメージングによる解析2022
- Author(s)
  白土玄、小西聡史、矢野智樹、柏原宏香、中山彰吾、勝野達也、Elisa Herawati、後藤慎平、　近藤玄、渡邊仁美、田村　淳、月田　早智子
- Organizer
  第74回細胞生物学会
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] TJMAP2は微小管依存的な相分離により細胞接着部位のアクチン重合を制御する2022
- Author(s)
  月田和人, 　矢野智樹、藤原、DayTimothyFrancisFrancis, 勝野達也、柏原宏香、竹永富妙子、田中啓雄、田村淳、月田早智子
- Organizer
  第74回細胞生物学会
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] TJMAP2は微小管依存的な相分離により細胞接着部位のアクチン重合を制御する2022
- Author(s)
  月田和人, 　矢野智樹、藤原、Day Timothy Francis, 勝野達也、柏原宏香、竹永富妙子、田中啓雄、田村淳、月田早智子
- Organizer
  第74回細胞生物学会
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] StCldn18 deficiency activates signaling cascade towards gastric tumorigenesis in mice2021
- Author(s)
  Tamura, A. Suzuki, K., Tanaka, H., Yano, T., Hayashi, D., Sentani, K., Oshima, M., Yasui, W., and Tsukit, S.
- Organizer
  4th International Tight Junction Conference, Berlin (online conference)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] タイトジャンクションの変化はマウス胃腫瘍形成へのシグナルカスケードを活性化する2020
- Author(s)
  田村淳、鈴木浩也、田中啓雄、矢野智樹、仙谷和弘、大島正伸、安井弥、月田早智子
- Organizer
  第 79 回日本癌学会学術総会(Web 開催)
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] 研究人生中間地点におけるこれまでの視点とこれからの視点2020
- Author(s)
  矢野智樹
- Organizer
  日本畜産学会第 128 回大会(Web 開催)
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] 新規 PCP 制御因子 Daple による微小管ネットワーク制御機構の解明2020
- Author(s)
  中山彰吾、小西聡史、難波利典、高岸麻紀、矢野智樹、古田健也、石原秀至、大岩和弘、高橋雅英、月田早智子
- Organizer
  第 72 回日本細胞生物学会、オンライン(Web 開催)
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] 新規PCP制御因子Dapleによる微小管ネットワーク制御機構の解明2020
- Author(s)
  中山彰吾, 小西聡史, 難波利典, 高岸麻紀, 矢野智樹, 古田健也, 石原秀至, 大岩和弘, 高橋雅英, 月田早智子
- Organizer
  第72回日本細胞生物学会、オンライン(Web開催)
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] Role of the arrangement of basal bodies in establishment of the coordinated ciliary beating in multi-ciliated cells2019
- Author(s)
  Nakayama, S., Konishi, S., Yano, T., Herawati, E., Kashihara, H., Tamura, A.,and Tsukita, S.
- Organizer
  ASCB/EMBO 2019 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] Planar cell polarity-dependent distribution of apical microtubules in tracheal multiciliated cells2019
- Author(s)
  Nakayama,S., Herawati,E., Takagishi,M., Torisawa,T., Namba,T., Ishihara,S., Yano,T., Tamura,A., Furuta,K., Oiwa,K., Takahashi,M., and Tsukita, S.
- Organizer
  The 20th International Conference on Systems Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] 気管上皮における平面内細胞極性因子Dapleを介した多繊毛同調運動形成機構2019
- Author(s)
  中山彰吾,ヘラワティエリサ, 高岸麻紀, 鳥澤嵩征,難波利典、矢野智樹、石原秀至,大岩和弘,高橋雅英、月田早智子
- Organizer
  第66回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] Role of Cep128 in formation of the centriolar subdistal appendage2019
- Author(s)
  Kashihara, H., Chiba, S., Kanno, S., Suzuki, K., Yano, T., and Tsukita, S.
- Organizer
  ASCB/EMBO 2019 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05468
[Presentation] TJ-アピカル複合体-その1-cingulinによる構築2016
- Author(s)
  矢野智樹
- Organizer
  生体運動合同班会議プログラム
- Place of Presentation
  キャンパスプラザ京都
- Year and Date
  2016-01-08
- Data Source
  KAKENHI-PROJECT-26840068
[Presentation] AMP活性化キナーゼによるタイトジャンクションタンパク質cingulinの分子形態の制御機構の解明2015
- Author(s)
  矢野智樹
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26840068

1. Tsukita Sachiko (00188517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. Danev Radostin (50415931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 中村駿 (80882779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 後藤慎平 (50747219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 近藤玄 (40243258)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 田村淳 (00362525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
7. 田中啓雄 (70795905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 柏原宏香 (20966692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. 八木健 (10241241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 足澤悦子 (00446262)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 足立誠 (30335244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 鈴木貴 (40114516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 入江克雅 (20415087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 佐藤俊朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 松本久子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 後藤祐平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yano Tomoki 矢野 智樹

YANO Tomoki 矢野 智樹

Tomoki Yano 矢野 智樹

Research Projects

Research Products

Co-Researchers

Exploration of Causative Genes for NAFLD and NASH Using Human Liver Organoids and Development of Potential TherapiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel approach focusing on the tight junction-based paracellular barrier combined with the apical barrier toward understanding and manipulating epithelial barriers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Elucidation of tumorigenesis mechanisms through signal transduction starting from tight junction.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

AMP-activated protein kinase regulates the function of tight junction.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Make Life Visible (Apical Cytoskeletons help define the barrier functions of epithelial cell sheets in biological systems.)2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Generation of human adult hepatocyte organoids with metabolic functions2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phase separation of an actin nucleator by junctional microtubules regulates epithelial function2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Planar cell polarity induces local microtubule bundling for coordinated ciliary beating2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A microtubule‐LUZP1 association around tight junction promotes epithelial cell apical constriction2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reciprocal Association between the Apical Junctional Complex and AMPK: A Promising Therapeutic Target for Epithelial/Endothelial Barrier Function?2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ions.2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] AMPK-dependent phosphorylation of cingulin reversibly regulates its binding to actin filaments and microtubules2018

Author(s)

Journal Title

DOI

Data Source

[Patent] 細胞外基質の非存在下でオルガノイドを培養するための薬剤2022

Inventor(s)

Industrial Property Rights Holder

Yano Tomoki 矢野智樹

YANO Tomoki 矢野智樹

Tomoki Yano 矢野智樹

[Presentation] 新規 PCP 制御因子 Daple による微小管ネットワーク制御機構の解明2020