TANIMOTO Kousuke 谷本幸介

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TANIMOTO Kosuke 谷本幸介

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Researcher Number	60611613
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 特任講師
Affiliation (based on the past Project Information) *help	2023: 長崎大学, 熱帯医学・グローバルヘルス研究科, 客員研究員 2013 – 2022: 東京医科歯科大学, 難治疾患研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor therapeutics Except Principal Investigator Complex systems / Basic Section 54030:Infectious disease medicine-related / Medium-sized Section 50:Oncology and related fields / Tumor biology / Tumor diagnostics
Keywords	Principal Investigator スプライシング制御 / がん体細胞変異 / データベース / TCGA / がん体細胞バリアント / スプライシング / エピゲノム / HDAC阻害剤 / ヒストンアセチル化 / ヒストン脱アセチル化酵素阻害剤 … More Except Principal Investigator … More がん / オートファジー / マイクロRNA / ゲノム / バイオマーカー / オミクス解析 / オミクス / 分子標的治療 / システム生物学 / エピゲノム / 遺伝子発現解析 / 回復期 / 急性期 / シングルセル解析 / T細胞受容体 / メモリー細胞 / エフェクター細胞 / シングルセルｍRNA発現解析 / T 細胞レパトワ解析 / T細胞レセプター遺伝子 / 重症型デング熱 / 細胞障害性T細胞 / ヒト免疫応答性 / ワクチン開発 / デング熱 / 代謝 / 代謝酵素 / 染色体構造 / ヒストンメチル化 / 核内遺伝子配置 / CREB / HIF / クロマチン構造 / 遺伝子発現 / 低酸素応答 / 癌 / 核酸創薬 / 既存薬再配置 / 浸潤・転移 / がん特性 / 核酸抗がん薬 / がん抑制型マイクロRNA / がん悪性特性 / DR / がん代謝異常 / がん細胞文脈 / DDS / 核酸医薬 / 上皮間葉転換（EMT) / 細胞文脈 / chromothripsis / 全ゲノムシークエンス / 次世代型シークエンサー / HOC313 / 次世代シークエンサー / 口腔がん / DNA二重鎖切断 / マイクロビーム照射装置 / ゲノム不安定性 / ゲノム再構成 / 染色体粉砕 / Chromothripsis / 分子標的薬 / DNAメチル化 / 癌抑制遺伝子 / 癌遺伝子 / 難治がん / ビメンチン / EMT / 治療標的 / p62 / 上皮間葉転換 / がん個別化医療 / 遺伝子ネットワーク / がん抑制遺伝子 / がん遺伝子 / 分子標的 / 薬剤耐性 / miRNA / NRF2 / バイオリソース / がん治療標的分子 / ゲノム・エピゲノム解析 Less

Single cell analysis of TCR genotypes of CTL at recovery phase of acute Dengue infection
- Principal Investigator
  
  Hirayama Kenji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagasaki University
Massive identification of somatic variants in exonic splicing enhancers using public databasesPrincipal Investigator
- Principal Investigator
  
  Tanimoto Kousuke
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical and Dental University
Comprehensive analysis of 3D nuclear gene position involved in malignant transformation of hypoxic cancer
- Principal Investigator
  
  Nakayama Koh
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Asahikawa Medical College
  Tokyo Medical and Dental University
exploring direct target genes of HDAC inhibitor for epigenomic evidenced based medicinePrincipal Investigator
- Principal Investigator
  
  Tanimoto Kousuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokyo Medical and Dental University
Establishment of novel concept for cancer diagnostics and therapeutics based on the systematic comprehension of cellular context in cancer
- Principal Investigator
  
  Inazawa Johji
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Medical and Dental University
Comprehensive understanding of molecular carcinogenesis through omics analysis and development of molecular diagnostics for personalized medicine
- Principal Investigator
  
  Johji Inazawa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Tokyo Medical and Dental University
Chromothripsis-like pattern in cancer-cell genome after irradiation by a focused vertical micro-beam system, SPICE
- Principal Investigator
  
  INAZAWA Johji
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Medical and Dental University
Integrative omics analysis to explore molecular targets and biomarkers for personalized medicine in cancer
- Principal Investigator
  
  INAZAWA Johji
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Medical and Dental University

All 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] Massive computational identification of somatic variants in exonic splicing enhancers using The Cancer Genome Atlas2019
- Author(s)
  Tanimoto Kousuke、Muramatsu Tomoki、Inazawa Johji
- Journal Title
  
  Cancer Medicine
  
  Volume: 8 Issue: 17 Pages: 7372-7384
- DOI
  10.1002/cam4.2619
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-18H02688, KAKENHI-PROJECT-18K15305
[Journal Article] miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein2018
- Author(s)
  Tonouchi Erina、Gen Yasuyuki、Muramatsu Tomoki、Hiramoto Hidekazu、Tanimoto Kousuke、Inoue Jun、Inazawa Johji
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 4482-4482
- DOI
  10.1038/s41598-018-22767-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K14630, KAKENHI-PROJECT-15K19040, KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-18H02688
[Journal Article] miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer2017
- Author(s)
  Hiramoto Hidekazu、Muramatsu Tomoki、Ichikawa Daisuke、Tanimoto Kousuke、Yasukawa Satoru、Otsuji Eigo、Inazawa Johji
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1
- DOI
  10.1038/s41598-017-04191-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-16K14630
[Journal Article] Genome-wide screening of DNA methylation associated with lymph node metastasis in esophageal squamous cell carcinoma.2017
- Author(s)
  Nagata H, Kozaki K, Muramatsu T, Hiramoto H, Tanimoto K, Fujiwara N, Imoto S, Ichikawa D, Otsuji E, Miyano S, Kawano T, Inazawa J
- Journal Title
  
  Oncotarget
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-15H05908
[Journal Article] Genome-wide screening of DNA methylation associated with lymph node metastasis in esophageal squamous cell carcinoma2017
- Author(s)
  Nagata Hiroaki、Kozaki Ken-Ichi、Muramatsu Tomoki、Hiramoto Hidekazu、Tanimoto Kousuke、Fujiwara Naoto、Imoto Seiya、Ichikawa Daisuke、Otsuji Eigo、Miyano Satoru、Kawano Tatsuyuki、Inazawa Johji
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 23 Pages: 37740-37750
- DOI
  10.18632/oncotarget.17147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05908, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-16K14630
[Journal Article] Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma.2016
- Author(s)
  Oikawa Y, Morita KI, Kayamori K, Tanimoto K, Sakamoto K, Katoh H, Ishikawa S, Inazawa J, Harada H
- Journal Title
  
  Cancer Sci.
  
  Volume: 108 Issue: 2 Pages: 256-266
- DOI
  10.1111/cas.13126
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-16H02481, KAKENHI-PROJECT-16H05510
[Journal Article] Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced Cytotoxicity.2015
- Author(s)
  2. Fujiwara N, Inoue J, Kawano T, Tanimoto K, Kozaki K, Inazawa J
- Journal Title
  
  Cancer Res.
  
  Volume: 75 Issue: 18 Pages: 3890-3901
- DOI
  10.1158/0008-5472.can-15-0257
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08301, KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-25250019, KAKENHI-PROJECT-26670815, KAKENHI-PROJECT-26293067
[Journal Article] Simultaneous detection of both single nucleotide variations and copy number alterations by next-generation sequencing in Gorlin syndrome2015
- Author(s)
  Morita K, Naruto T, Tanimoto K, Yasukawa C, Oikawa Y, Masuda K, Imoto I, Inazawa J, Omura K, Harada H.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 11 Pages: e0140480-e0140480
- DOI
  10.1371/journal.pone.0140480
- NAID
  120006871193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08949, KAKENHI-PROJECT-15K15735, KAKENHI-PLANNED-15H05908, KAKENHI-PROJECT-25250019, KAKENHI-PROJECT-26293304
[Patent] 食道がんのリンパ節転移可能性のデータ取得方法2017
- Inventor(s)
  稲澤譲治、村松智輝、永田啓明、谷本幸介、河野辰幸　他2名
- Industrial Property Rights Holder
  国立大学法人東京医科歯科大学、株式会社ビー・エム・エル
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-036122
- Filing Date
  2017-02-28
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] 統合的 mRNA, miRNA 発現情報を基盤とした独自のマイクロ RNA標的遺伝子予測データベースの構築2019
- Author(s)
  内藤諒、村松智輝、谷本幸介、稲澤譲治
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein2018
- Author(s)
  Muramatsu T, Tonouchi E, Gen Y, Hiramoto H, Tanimoto K, Inoue J, Inazawa J
- Organizer
  AACR Annual Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] Exploring target genes of eukaryotic initiation factor 5A in cancer using RNA sequence analysis2016
- Author(s)
  Muramatsu T, Tanimoto K, Inazawa J
- Organizer
  AACR
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05908
[Presentation] Exploring target genes of eukaryotic initiation factor 5A in cancer using RNA sequence analysis2016
- Author(s)
  Muramatsu T, Tanimoto K, Inazawa J
- Organizer
  AACR
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25250019
[Presentation] Exploring target genes of eukaryotic initiation factor 5A in cancer using RNA sequence analysis2016
- Author(s)
  Muramatsu T, Tanimoto K, Inazawa J
- Organizer
  AACR2016 Annual Meeting
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05908

1. INAZAWA Johji (30193551)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
2. INOUE Jun (50568326)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. KOZAKI Ken-ichi (50270715)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Muramatsu Tomoki (90732553)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
5. Nakayama Koh (10451923)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Hirayama Kenji (60189868)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 玄泰行 (80596156)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 谷水直樹 (00333386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 與那城亮 (60453809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 水上修作 (00508971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. グエンフイティエン (20457526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 増田清士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TANIMOTO Kousuke 谷本 幸介

TANIMOTO Kosuke 谷本 幸介

Research Projects

Research Products

Co-Researchers

Single cell analysis of TCR genotypes of CTL at recovery phase of acute Dengue infection

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Massive identification of somatic variants in exonic splicing enhancers using public databasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of 3D nuclear gene position involved in malignant transformation of hypoxic cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

exploring direct target genes of HDAC inhibitor for epigenomic evidenced based medicinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of novel concept for cancer diagnostics and therapeutics based on the systematic comprehension of cellular context in cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive understanding of molecular carcinogenesis through omics analysis and development of molecular diagnostics for personalized medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chromothripsis-like pattern in cancer-cell genome after irradiation by a focused vertical micro-beam system, SPICE

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Integrative omics analysis to explore molecular targets and biomarkers for personalized medicine in cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Massive computational identification of somatic variants in exonic splicing enhancers using The Cancer Genome Atlas2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide screening of DNA methylation associated with lymph node metastasis in esophageal squamous cell carcinoma.2017

Author(s)

Journal Title

Data Source

[Journal Article] Genome-wide screening of DNA methylation associated with lymph node metastasis in esophageal squamous cell carcinoma2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma.2016

Author(s)

Journal Title

TANIMOTO Kousuke 谷本幸介

TANIMOTO Kosuke 谷本幸介