Yokoyama Yuki 横山雄起

… Alternative Names

Yokoyama Yuhki 横山雄起

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Researcher Number	60615714
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院医学系研究科, 助教 2022 – 2024: 大阪大学, 大学院医学系研究科, 助教 2018 – 2022: 大阪大学, 医学系研究科, 助教 2017: 大阪大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 49010:Pathological biochemistry-related / Pathological medical chemistry Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 53010:Gastroenterology-related / Basic Section 42020:Veterinary medical science-related / Basic Section 90130:Medical systems-related / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 62010:Life, health and medical informatics-related
Keywords	Principal Investigator 三次元ゲノム構造 / 大腸癌 / リンチ症候群 / ノンコーディングRNA / CCAT1 / KLF5 / 癌 / ゲノム / 癌幹細胞 / エピジェネティクス … More Except Principal Investigator … More 癌幹細胞 / DDS / sCA / 癌微小環境 / KLF5 / 大腸癌 / 遠隔診断 / クロマチンパターン / 細胞診断 / ホモロジー / Sox2 / SOX2 / 癌精巣抗原 / 転移 / 多分子制御 / 核酸医療 / 核酸療法 / 扁平上皮癌 / 犬 / 消化器癌 / 特異抗体 / 放射線 / 癌幹細胞性 / Lrig1 / 抗体治療 / 核酸治療 / 中皮腫 / 核酸医薬 / 悪性中皮腫 / Sdc4 / IFN alpha / インターフェロンアルファ / CpG / 肝細胞癌 / データの構造化 / ホモロジープロファイル法 / ビッグデータ / クロマチン解析 / ホモロジー法 / 効果増強 / 高分子薬剤 / 腫瘍間質 / 癌間質 / ナノ粒子 / 高分子製剤 / ICG / インテグリン / 微小環境 / インテグリンB1 / 高分子医薬 / シングルセル解析 / ヒト検体 / 動物モデル / 間葉系幹細胞 / 浮遊中皮細胞 / 腹膜播種 / 中皮細胞 / 浮遊播種病変 / 卵巣癌 / 三次元ゲノム構造 / ｐ５３ / ノックアウトマウス / 遺伝子発現 / p53 / 大腸がん / MAF / クロマチン / 画像診断 Less

MSH2プロモーターの異常活性化が三次元ゲノム構造を介して大腸癌の悪性化に与える影響Principal Investigator
- Principal Investigator
  
  横山雄起
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  The University of Osaka
犬口腔扁平上皮癌の根治を目指した全身投与可能な核酸療法の確立
- Principal Investigator
  
  野口俊助
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Osaka University
多分子標的型核酸と高性能化DDSによって転移性癌をリセットするムーンショット計画
- Principal Investigator
  
  山本浩文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Osaka University
正常細胞に影響を与えない癌幹細胞特異抗体の取得
- Principal Investigator
  
  幸田志穂里
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
正常組織に影響を与えない癌幹細胞標的分子の探索
- Principal Investigator
  
  奥崎大介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
未分化マーカーを指標とした新規癌幹細胞マーカーの取得
- Principal Investigator
  
  吉村大士
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
KLF5を基軸とした新たな癌関連分子制御メカニズムの解明
- Principal Investigator
  
  三代雅明
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Sapporo Medical University
  Osaka University
リンチ症候群関連大腸癌の病態に寄与する三次元ゲノム構造の解明Principal Investigator
- Principal Investigator
  
  横山雄起
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
シングルセル解析を駆使した癌幹細胞の捕捉と新規治療法の開発
- Principal Investigator
  
  Shamma A.A.Awad
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
A strategy for improving tumor microenvironment that contributes to the efficacy of macromolecular drugs.
- Principal Investigator
  
  Yamamoto Hirofumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Osaka University
Development of lung cytodiagnosis support system using homology profile method
- Principal Investigator
  
  Nakane Kazuaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Osaka University
Therapy against HCC by potential ability of CpG endowed by DDS
- Principal Investigator
  
  Tsujimura Naoto
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka University
Elucidation of significance of Sdc4 in malignant mesothelioma and development of novel therapy
- Principal Investigator
  
  Shibata Satoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka University
Mechanism of cancer stem cell maintenance by Lrig1 using transgenic mice
- Principal Investigator
  
  Makino Shunichiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Elucidation of the role of the MAF gene in the occurrence and progression of colorectal cancer
- Principal Investigator
  
  Okuzaki Daisuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka University
Identification of KLF5 related three-dimensional genome structure
- Principal Investigator
  
  Otsuka Masahisa
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Investigation of cancer stem-like properties of ovarian cancer cells associated with the floating mesothelium
- Principal Investigator
  
  Shishido Akemi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Osaka University
The regulation mechanism of KLF5 and CCAT1 gene expression via three-dimensional genome structurePrincipal Investigator
- Principal Investigator
  
  Yokoyama Yuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Osaka University
Cytological image analysis via the concept of the homology
- Principal Investigator
  
  Nakane Kazuaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Osaka University
Elucidation of three dimensional genome organization by Brd4 that confers cancer stemnessPrincipal Investigator
- Principal Investigator
  
  Yokoyama Yuhki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University

All 2023 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Tumor-suppressive role of the musculoaponeurotic fibrosarcoma gene in colorectal cancer2023
- Author(s)
  Itakura Hiroaki、Hata Tsuyoshi、Okuzaki Daisuke、Takeda Koki、Iso Kenji、Qian Yamin、Morimoto Yoshihiro、Adachi Tomohiro、Hirose Haruka、Yokoyama Yuhki、Ogino Takayuki、Miyoshi Norikatsu、Takahashi Hidekazu、Uemura Mamoru、Mizushima Tsunekazu、Hinoi Takao、Mori Masaki、Doki Yuichiro、Eguchi Hidetoshi、Yamamoto Hirofumi
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 4 Pages: 106478-106478
- DOI
  10.1016/j.isci.2023.106478
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08356, KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-23K27671
[Journal Article] A quantitative evaluation method utilizing the homology concept to assess the state of chromatin within the nucleus of lung cancer2023
- Author(s)
  Yokoyama Yuhki、Kanayama Kazuki、Iida Kento、Onishi Masako、Nagatomo Tadasuke、Ito Mayu、Nagumo Sachiko、Kawahara Kunimitsu、Morii Eiichi、Nakane Kazuaki、Yamamoto Hirofumi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1
- DOI
  10.1038/s41598-023-46213-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03839
[Journal Article] Improved In Vivo Delivery of Small RNA Based on the Calcium Phosphate Method2021
- Author(s)
  Wu Xin、Yokoyama Yuhki、Takahashi Hidekazu、Kouda Shihori、Yamamoto Hiroyuki、Wang Jiaqi、Morimoto Yoshihiro、Minami Kazumasa、Hata Tsuyoshi、Shamma Awad、Inoue Akira、Ohtsuka Masahisa、Shibata Satoshi、Kobayashi Shogo、Akai Shuji、Yamamoto Hirofumi
- Journal Title
  
  Journal of Personalized Medicine
  
  Volume: 11 Issue: 11 Pages: 1160-1160
- DOI
  10.3390/jpm11111160
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07632, KAKENHI-PROJECT-21H04831
[Presentation] 大腸癌の発生・進展における MAF 遺伝子の役割解明2021
- Author(s)
  板倉弘明、奥崎大介、横山雄起、関戸悠紀、波多豪、荻野崇之、三吉範克、高橋秀和、植村守、土岐祐一郎、江口英利、山本浩文
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08356
[Presentation] 大腸癌における三次元ゲノム構造を介したKLF5遺伝子発現制御メカニズム2020
- Author(s)
  横山雄起、武田和、藤田敏次、奥崎大介、杉山真美、浅井香穂、高橋秀和、藤井穂高、森正樹、山本浩文
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16541
[Presentation] ホモロジー概念を用いた大腸癌発生過程の数理学的病理診断2019
- Author(s)
  松田美和、中根和昭、横山雄起、南雲サチ子、森井英一、山本浩文
- Organizer
  第30回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-18H03333
[Presentation] The identification of KLF5 enhancer region in colorectal cancer2019
- Author(s)
  Yuhki Yokoyama, Takashi Takeda, Kumi Kitagawa, Daisuke Okuzaki, Toshitsugu Fujita, Hodaka Fujii, Hirofumi Yamamoto
- Organizer
  KEYSTONE SYMPOSIA 3D Genome:Gene Regulation and Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15618
[Presentation] BET阻害剤はALDH1A1遺伝子のスーパーエンハンサーを標的として卵巣癌のALDH活性を抑制する2018
- Author(s)
  横山雄起、武田和、北川公望、森誠司、水島恒和、森正樹、松浦成昭、山本浩文
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15618
[Presentation] 大腸癌細胞株におけるBET阻害剤JQ1の効果2018
- Author(s)
  武田和、横山雄起、北川公望、三吉範克、高橋秀和、原口直紹、西田尚弘、畑泰司、松田宙、水島恒和、土岐祐一郎、森正樹、山本浩文
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K15618

1. Yamamoto Hirofumi (30322184)

# of Collaborated Projects: 17 results

# of Collaborated Products: 5 results
2. Okuzaki Daisuke (00346131)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
3. 江口英利 (90542118)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 森正樹 (70190999)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. Nakane Kazuaki (10298804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. Shibata Satoshi (00423153)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 安藤幸滋 (20608864)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 伊藤心二 (90382423)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 中川貴之 (40447363)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 赤井周司 (60192457)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 名取幸和 (40572912)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. Otsuka Masahisa (20597455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Shishido Akemi (30838909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Tsujimura Naoto (10804198)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Makino Shunichiro (60745446)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 堤康嘉 (30450141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Shamma A.A.Awad (50402839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 橘理恵 (90435462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 河原邦光 (70755313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 高橋秀和 (10528508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小泉雅彦 (90186594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 幸田志穂里 (00866593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 三代雅明 (70645077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 野口俊助 (10701295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 古家優 (30500706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 坂東聡史 (50990660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 谷口博昭 (90563289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 吉村大士 (90882233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. MINAMI Kazumasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yokoyama Yuki 横山 雄起

Yokoyama Yuhki 横山 雄起

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MSH2プロモーターの異常活性化が三次元ゲノム構造を介して大腸癌の悪性化に与える影響Principal Investigator

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リンチ症候群関連大腸癌の病態に寄与する三次元ゲノム構造の解明Principal Investigator

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Yokoyama Yuki 横山雄起

Yokoyama Yuhki 横山雄起