Kaihara Keiko 貝原恵子

Researcher Number	60638641
Other IDs
Affiliation (Current)	2025: 岡山大学, 総合技術部, 技術専門職員
Affiliation (based on the past Project Information) *help	2023 – 2024: 岡山大学, 総合技術部, 技術専門職員 2017 – 2023: 岡山大学, 医学部, 技術専門職員
Review Section/Research Field	Principal Investigator Basic Section 90110:Biomedical engineering-related / Biomedical engineering/Biomaterial science and engineering Except Principal Investigator Basic Section 90110:Biomedical engineering-related / Basic Section 55030:Cardiovascular surgery-related
Keywords	Principal Investigator NOX4 / 活性酸素（ROS） / 心不全 / メカノトランスダクション / 疑似微小重力装置搭載型蛍光顕微鏡 / 蛍光遠心顕微鏡 / 重力変化 / カルシウムハンドリング / 心筋細胞 / 活性酸素 … More / NADPHオキシダーゼ（NOX）4 / NOX4（NADPH Oxidase ) / 活性酸素 ( ROS ) / NOX4 ( NADPH Oxidase ) / 生理活性 / 循環器・高血圧 / 生理学 / 活性酸素( ROS ) / NADPH oxidase 4（NOX4) / 圧負荷 / 単離心筋細胞 / 活性酸素（ROS) / NADPH oxidase 4 … More Except Principal Investigator ミトコンドリア膜電位 / 心筋力学 / メカノトランスダクション / 酸化ストレス / 機械的負荷 / 活性酸素 / 機械感受性 / カーボンファイバー / FrankーStarlingの法則 / 単離心筋細胞の力学機能評価 / 長さ張力関係 / ヒト単離心筋細胞 Less

Effects of gravity-mediated mechanotransduction on cardiomyocyte calcium handlingPrincipal Investigator
- Principal Investigator
  
  貝原恵子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Okayama University
Force-Length Relationによる単離ヒト心筋細胞の機能評価
- Principal Investigator
  
  小松弘明
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Okayama University
The Role of ROS Signaling in Regulating Myocardial Mechanosensitive Responses and Its Application to Heart Failure Therapy
- Principal Investigator
  
  Iribe Gentaro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Asahikawa Medical College
Investigation of NOX4-mediated mechanotransduction in mechanically-induced cardiac failurePrincipal Investigator
- Principal Investigator
  
  貝原恵子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Okayama University
Physiological and pathophysiological role of NOX4 in cardiac mechano-transductionPrincipal Investigator
- Principal Investigator
  
  Kaihara Keiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Okayama University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Stretch‐induced reactive oxygen species contribute to the Frank-Starling mechanism2023
- Author(s)
  Kaihara Keiko、Kai Hiroaki、Chiba Yumiko、Naruse Keiji、Iribe Gentaro
- Journal Title
  
  The Journal of Physiology
  
  Volume: - Issue: 18 Pages: 1-16
- DOI
  10.1113/jp284283
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12640, KAKENHI-PROJECT-22K16125, KAKENHI-PROJECT-21K20886, KAKENHI-PROJECT-20K12598, KAKENHI-PROJECT-21H04960
[Journal Article] High hydrostatic pressure induces slow contraction in mouse cardiomyocytes2023
- Author(s)
  Yamaguchi Yohei、Nishiyama Masayoshi、Kai Hiroaki、Kaneko Toshiyuki、Kaihara Keiko、Iribe Gentaro、Takai Akira、Naruse Keiji、Morimatsu Masatoshi
- Journal Title
  
  Biophysical Journal
  
  Volume: 122 Issue: 1 Pages: 267-267
- DOI
  10.1016/j.bpj.2022.11.2940
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12598, KAKENHI-PROJECT-21H04960
[Journal Article] High hydrostatic pressure induces slow contraction in mouse cardiomyocytes2022
- Author(s)
  Yamaguchi Yohei、Nishiyama Masayoshi、Kai Hiroaki、Kaneko Toshiyuki、Kaihara Keiko、Iribe Gentaro、Takai Akira、Naruse Keiji、Morimatsu Masatoshi
- Journal Title
  
  Biophysical Journal
  
  Volume: 121 Issue: 17 Pages: 3286-3294
- DOI
  10.1016/j.bpj.2022.07.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12598, KAKENHI-PROJECT-21K12645, KAKENHI-PROJECT-21K15338, KAKENHI-PUBLICLY-22H05697, KAKENHI-PLANNED-21H05128, KAKENHI-PROJECT-21H04960, KAKENHI-PROJECT-23K23190
[Journal Article] Ischemia Enhances the Acute Stretch-Induced Increase in Calcium Spark Rate in Ventricular Myocytes2020
- Author(s)
  Breanne A. Cameron, Hiroaki Kai, Keiko Kaihara, Gentaro Iribe and T. Alexander Quinn
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 11 Pages: 289-298
- DOI
  10.3389/fphys.2020.00289
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01359
[Journal Article] Mechano-sensitivity of mitochondrial function in mouse cardiac myocytes2017
- Author(s)
  Iribe Gentaro、Kaihara Keiko、Yamaguchi Yohei、Nakaya Michio、Inoue Ryuji、Naruse Keiji
- Journal Title
  
  Progress in Biophysics and Molecular Biology
  
  Volume: 130 Pages: 315-322
- DOI
  10.1016/j.pbiomolbio.2017.05.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01359, KAKENHI-PUBLICLY-17H05510, KAKENHI-PROJECT-26220203, KAKENHI-PROJECT-15H04678, KAKENHI-PROJECT-17H03984
[Presentation] Role of Physiological Assessment in the Treatment of Congenital Heart Disease2024
- Author(s)
  Yasuhiro Kotani, Hiroaki Komatsu, Keiko Kaihara, Keiji Naruse, Gentaro Iribe, Shingo Kasahara,
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K12598
[Presentation] Single cell mechanics of human-cardiomyocytes assessed by cellular force-length relationships2023
- Author(s)
  Hiroaki Komatsu, Yasuhiro Kotani, Keiko Kaihara, Keiji Naruse,Shingo Kasahara, Gentaro Iribe.
- Organizer
  日本生理学会第100回記念大会
- Data Source
  KAKENHI-PROJECT-20K12598
[Presentation] 新たな蛍光顕微鏡を用いた過重力下のオルガネラ挙動の解明2023
- Author(s)
  貝原恵子　松浦宏治　成瀬恵治
- Organizer
  第62回日本生体医工学会大会
- Data Source
  KAKENHI-PROJECT-20K12598
[Presentation] ヒト単離心筋細胞における長さ張力関係を用いた力学機能評価2022
- Author(s)
  小松　弘明，小谷　恭弘，貝原　恵子，成瀬　恵治，笠原　真悟，入部　玄太郎
- Organizer
  第45回日本生体医工学会中国四国支部大会
- Data Source
  KAKENHI-PROJECT-20K12598
[Presentation] Role of NOX4-TRPV1 interaction on single cell mechanics in mouse ventricular cardiomyocytes.2022
- Author(s)
  Keiko Kaihara, Keiji Naruse, Gentaro Iribe.
- Organizer
  第99回　日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K12598
[Presentation] 過重力下における細胞内小器官観測可能な新たな蛍光遠心顕微鏡の開発2022
- Author(s)
  貝原恵子，成瀬恵治
- Organizer
  第61回日本生体医工学会
- Data Source
  KAKENHI-PROJECT-20K12598
[Presentation] Effects of NOX4-induced ROS on single cell mechanics in mouse ventricular cardiomyocytes.2021
- Author(s)
  Keiko Kaihara, Keiji Naruse, Gentaro Iribe
- Organizer
  第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会　合同大会
- Data Source
  KAKENHI-PROJECT-20K12598
[Presentation] Involvement of myocardial acute stretch-induced ROS production in pressure overload-induced contractile dysfunction in mouse hearts2020
- Author(s)
  Keiko Kaihara, Keiji Naruse, Gentaro Iribe
- Organizer
  第59回日本生体医工学会大会
- Data Source
  KAKENHI-PROJECT-20K12598
[Presentation] Effects of NADPH oxidase (NOX) 4 on single cell mechanics in mouse ventricular cardiomyocytes.2020
- Author(s)
  貝原恵子、成瀬恵治、入部玄太郎
- Organizer
  第97回　日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K01359
[Presentation] Role of pannexin hemichannel on stretch-induced mitochondrial hyperpolarization in cardiomyocytes2019
- Author(s)
  Daisuke Katsura, Gentaro Iribe, Keiko Kaihara, Keiji Naruse.
- Organizer
  9th FAOPS CONGRESS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01359
[Presentation] マウス心筋の伸展誘発性活性酸素産生およびミトコンドリア過分極におけるパネキシンヘミチャネルの役割2019
- Author(s)
  桂大輔、貝原恵子、赤嶺透子、成瀬恵治、入部玄太郎
- Organizer
  第71回　日本生理学会中国四国地方会
- Data Source
  KAKENHI-PROJECT-17K01359
[Presentation] 心筋バイオメカニクス制御におけるプリン作動性シグナリングの役割2019
- Author(s)
  赤嶺透子、貝原恵子、桂大輔、成瀬恵治、入部玄太郎
- Organizer
  第42回　日本生体医工学会中国四国支部大会
- Data Source
  KAKENHI-PROJECT-17K01359
[Presentation] Effects of stretch-induced reactive oxygen species on single cell mechanics in mouse ventricular cardiomyocytes.2018
- Author(s)
  Keiko Kaihara, Gentaro Iribe ,Yohei Hayama, Hiroaki Kai, Keiji Naruse
- Organizer
  第95回　日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K01359
[Presentation] Single cell mechanics effects of NADPH oxidase (NOX) 4 in mouse ventricular cardiomyocytes.2018
- Author(s)
  Keiko Kaihara, Gentaro Iribe, Hiroaki Kai, Keiji Naruse.
- Organizer
  第56回　生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17K01359
[Presentation] Effects of stretch-induced reactive oxygen species on calcium handling in mouse ventricular cardiomyocytes2018
- Author(s)
  Hiroaki Kai, Gentaro Iribe, Keiko Kaihara, Yohei Yamaguchi, Keiji Naruse
- Organizer
  第95回　日本生理学会大会
- Data Source
  KAKENHI-PROJECT-17K01359

1. Iribe Gentaro (90284885)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
2. 成瀬恵治 (40252233)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. 小松弘明 (40894952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小谷恭弘 (90534678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山口陽平 (40831912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 金子智之 (80638643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 千葉弓子 (70835777)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 松浦宏治 (70443223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kaihara Keiko 貝原 恵子

Research Projects

Research Products

Co-Researchers

Effects of gravity-mediated mechanotransduction on cardiomyocyte calcium handlingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Force-Length Relationによる単離ヒト心筋細胞の機能評価

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The Role of ROS Signaling in Regulating Myocardial Mechanosensitive Responses and Its Application to Heart Failure Therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of NOX4-mediated mechanotransduction in mechanically-induced cardiac failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological and pathophysiological role of NOX4 in cardiac mechano-transductionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Stretch‐induced reactive oxygen species contribute to the Frank-Starling mechanism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High hydrostatic pressure induces slow contraction in mouse cardiomyocytes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High hydrostatic pressure induces slow contraction in mouse cardiomyocytes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ischemia Enhances the Acute Stretch-Induced Increase in Calcium Spark Rate in Ventricular Myocytes2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechano-sensitivity of mitochondrial function in mouse cardiac myocytes2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Role of Physiological Assessment in the Treatment of Congenital Heart Disease2024

Author(s)

Organizer

Data Source

[Presentation] Single cell mechanics of human-cardiomyocytes assessed by cellular force-length relationships2023

Author(s)

Organizer

Data Source

[Presentation] 新たな蛍光顕微鏡を用いた過重力下のオルガネラ挙動の解明2023

Author(s)

Organizer

Data Source

[Presentation] ヒト単離心筋細胞における長さ張力関係を用いた力学機能評価2022

Author(s)

Organizer

Data Source

[Presentation] Role of NOX4-TRPV1 interaction on single cell mechanics in mouse ventricular cardiomyocytes.2022

Author(s)

Organizer

Data Source

[Presentation] 過重力下における細胞内小器官観測可能な新たな蛍光遠心顕微鏡の開発2022

Kaihara Keiko 貝原恵子