Osone Shinya 大曽根眞也

Researcher Number	60708717
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2019: 京都府立医科大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator CAR-T療法 / FLT3 / CD19 / ピギーバックトランスポゾンベクター / 急性リンパ性白血病 / KMT2A再構成 / CAR-T細胞療法 / 乳児 / JAK阻害剤 / CAR-T細胞

The development of CAR-T therapy targeting FLT3 and CD19 for infant acute lymphoblastic leukemiaPrincipal Investigator
- Principal Investigator
  
  大曽根眞也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Development of CAR-T cell therapy for KMT2A-rearranged acute lymphoblastic leukemiaPrincipal Investigator
- Principal Investigator
  
  Osone Shinya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto Prefectural University of Medicine

All 2022 2021 2019

All Journal Article Presentation

[Journal Article] Targeting FLT3-specific chimeric antigen receptor T cells for acute lymphoblastic leukemia with KMT2A rearrangement2022
- Author(s)
  Suematsu Masaya、Yagyu Shigeki、Yoshida Hideki、Osone Shinya、Nakazawa Yozo、Sugita Kanji、Imamura Toshihiko、Iehara Tomoko
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 4 Pages: 957-968
- DOI
  10.1007/s00262-022-03303-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07825, KAKENHI-PROJECT-20K07641
[Journal Article] Supportive care for hemostatic complications associated with pediatric leukemia: a national survey in Japan2019
- Author(s)
  Shinya Osone, Keitaro Fukushima, Michihiro Yano, Mariko Kakazu, Hirozumi Sano, Yoko Kato, Yuichi Shinkoda, Kunihiro Shinoda, Naoko Mori, Souichi Adachi
- Journal Title
  
  International Journal of Hematology
  
  Volume: 110 Issue: 6 Pages: 743-750
- DOI
  10.1007/s12185-019-02740-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08326, KAKENHI-PROJECT-17H04110
[Journal Article] Disordered hemostasis associated with severely depressed fibrinolysis demonstrated using a simultaneous thrombin and plasmin generation assay during L‐asparaginase induction therapy in pediatric acute lymphoblastic leukemia2019
- Author(s)
  Ishihara Takashi、Nogami Keiji、Ochi Satoshi、Ishida Toshiaki、Kosaka Yoshiyuki、Sawada Akihisa、Inoue Masami、Osone Shinya、Imamura Toshihiko、Hosoi Hajime、Shima Midori
- Journal Title
  
  Pediatric Blood & Cancer
  
  Volume: 67 Issue: 1
- DOI
  10.1002/pbc.28016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08304, KAKENHI-PROJECT-19K08326
[Journal Article] Cellular and molecular characteristics of established neuroblastoma cell lines.2019
- Author(s)
  Tohru Sugimoto, Hiroshi Kuroda, Sigeki Yagyu, Takahiro Gotoh, Shinya Osone, Shinchi Tamura, Tomoko Iehara, Hajime Hosoi
- Journal Title
  
  Journal of Cancer Research and Therapeutic Oncology
  
  Volume: 7 Pages: 1-15
- DOI
  10.17303/jcrto.2019.7.201
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08326
[Journal Article] Successful treatment with 2-chlorodeoxyadenosine of refractory pediatric Langerhans cell histiocytosis with initial involvement of the gastrointestinal tract2019
- Author(s)
  Azusa Mayumi, Toshihiko Imamura, Kenichi Sakamoto, Takeshi Ota, Shinya Osone, Ikuya Usami, Hajime Hosoi
- Journal Title
  
  International Journal of Hematology
  
  Volume: 110 Issue: 6 Pages: 756-762
- DOI
  10.1007/s12185-019-02711-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] Development of multi-antigen specific chimeric antigen receptor T cells for acute lymphoblastic leukemia with rearrangement of KMT2A gene.2021
- Author(s)
  Suematsu M, Yagyu S, Osone S, et al.
- Organizer
  第63回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] BRCA1とMLH1の胚細胞変異を有する急性巨核芽球性白血病（AMKL）の1例2019
- Author(s)
  末松正也，今村俊彦，大曽根眞也，堂　淳子，吉田仁典，加藤元博，細井　創
- Organizer
  第61回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] 再発B前駆細胞型急性リンパ性白血病のクローン進化の検討2019
- Author(s)
  眞弓あずさ，今村俊彦，飯島友加，冨井敏宏，西島　大，友安千紘，矢野未央，田村真一，大曽根眞也，石田宏之，白石友一，黒田啓史，宮野　悟，堀部敬三，小川誠治，眞田　昌，細井　創
- Organizer
  第122回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] 小児がん拠点病院である当院における終末期在宅医療の現状2019
- Author(s)
  宮地　充，柳生茂希，大曽根眞也，土屋邦彦，今村俊彦，家原知子，細井　創
- Organizer
  第57回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] FANCI遺伝子変異が同定された乳児期発症ファンコニ―貧血の1例2019
- Author(s)
  浦田貴代，今村俊彦，大曽根眞也，村松秀城，高橋義行，細井　創
- Organizer
  第61回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08326
[Presentation] 類白血病反応を伴った1型高IgE症候群の乳児例2019
- Author(s)
  野田佳奈子，今村俊彦，大曽根眞也，岡本圭祐，井澤和司，金兼弘和，牧野　茂，今宿晋作，細井　創
- Organizer
  第61回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08326

1. 家原知子 (20285266)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 今村俊彦 (30444996)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. 柳生茂希 (10572547)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 細井創 (20238744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. NOGAMI Keiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 嶋緑倫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 石原卓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Osone Shinya 大曽根 眞也

Research Projects

Research Products

Co-Researchers

The development of CAR-T therapy targeting FLT3 and CD19 for infant acute lymphoblastic leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of CAR-T cell therapy for KMT2A-rearranged acute lymphoblastic leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Targeting FLT3-specific chimeric antigen receptor T cells for acute lymphoblastic leukemia with KMT2A rearrangement2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Supportive care for hemostatic complications associated with pediatric leukemia: a national survey in Japan2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disordered hemostasis associated with severely depressed fibrinolysis demonstrated using a simultaneous thrombin and plasmin generation assay during L‐asparaginase induction therapy in pediatric acute lymphoblastic leukemia2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cellular and molecular characteristics of established neuroblastoma cell lines.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful treatment with 2-chlorodeoxyadenosine of refractory pediatric Langerhans cell histiocytosis with initial involvement of the gastrointestinal tract2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Development of multi-antigen specific chimeric antigen receptor T cells for acute lymphoblastic leukemia with rearrangement of KMT2A gene.2021

Author(s)

Organizer

Data Source

[Presentation] BRCA1とMLH1の胚細胞変異を有する急性巨核芽球性白血病（AMKL）の1例2019

Author(s)

Organizer

Data Source

[Presentation] 再発B前駆細胞型急性リンパ性白血病のクローン進化の検討2019

Author(s)

Organizer

Data Source

[Presentation] 小児がん拠点病院である当院における終末期在宅医療の現状2019

Author(s)

Organizer

Data Source

[Presentation] FANCI遺伝子変異が同定された乳児期発症ファンコニ―貧血の1例2019

Author(s)

Organizer

Data Source

[Presentation] 類白血病反応を伴った1型高IgE症候群の乳児例2019

Author(s)

Organizer

Data Source

Osone Shinya 大曽根眞也