Hiroshima Yukihiko 廣島幸彦

… Alternative Names

HIROSHIMA Yukihiko 廣島幸彦

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Researcher Number	60718021
Other IDs
Affiliation (Current)	2025: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん治療学部(がんゲノム診療科), 部長 2025: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん治療学部, 医長 2025: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所, 医長 2025: 横浜市立大学, 医学研究科, 連携大学院客員准教授
Affiliation (based on the past Project Information) *help	2023: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん治療学部(がんゲノム診療科), 部長 2019 – 2023: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所, 医長 2021: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所がん治療学部, 部長 2021: 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所, 部長 2019: 横浜市立大学, 医学研究科, 客員講師 … More 2017 – 2018: 横浜市立大学, 附属病院, 助教 2015 – 2016: 横浜市立大学, 医学研究科, 客員研究員 2013 – 2015: 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 2013: 横浜市立大学, 医学研究科, 客員研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Tumor biology Except Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator 微小環境 / 膵癌 / PDX / TGFβ / SMAD4 / 癌関連線維芽細胞 / 癌間質相互作用 / エピゲノム / 転写因子 / CUT&Tag … More / ATAC-seq / CITE-seq / 癌微小環境 / 腫瘍免疫 / 遺伝子発現 / オルガノイド / realtime imaging / プロテオーム解析 / 間質 / TGFーβ / 蛍光イメージング / マウスモデル … More Except Principal Investigator 膵癌 / 浸潤 / がん微小環境 / CRMP4 / 免疫 / 転移性肝癌 / リン酸化 / 膵炎 / 転移 / 診断マーカー / 微小環境 / 低脂質 / 早期診断 / 腫瘍マーカー / 低栄養 / 低酸素 / Virtual dissection / PDXマウス / Virtual dissectionモデル / IRF-5 / TAM / NACRT / 性差 / 腫瘍関連マクロファージ / 癌免疫 / 術前化学放射線療法 / 膵癌間質組織 / 発癌 / 膵前癌病変 / 肝再生シグナル / ALPPS手術 / 門脈塞栓 / ALPPS / 肝切除 / 肝再生 / GSK3β / CDK5 / マウスモデル / Kras / CD13 / 肝転移 / 大腸癌 / E cadherin / CD44 / CD133 / 大腸癌肝転移 / 癌幹細胞 / イメージング / 間質 / ノックアウトマウス / 癌微小環境 Less

エピゲノム解析を用いたサブタイプ別の膵癌-間質相互作用マスター制御因子の探索Principal Investigator
- Principal Investigator
  
  廣島幸彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Prediction of cancer microenvironment using deconvolution analysis
- Principal Investigator
  
  Kasajima Rika
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Development of novel diagnostic markers for pancreatic cancer focused on the tumor microenvironment associated with hypoxia and nutrient depletion.
- Principal Investigator
  
  miyagi yohei
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanagawa Cancer Center Research Institute
The influence of neoadjuvant chemoradiotherapy upon tumor microenvironment in pancreatic cancer
- Principal Investigator
  
  ENDO Itaru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Yokohama City University
Discovering tumor microenvironment of pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Hiroshima Yukihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanagawa Cancer Center Research Institute
Evaluation of the function of CRMP4 in pancreatic cancer and precursor lesions
- Principal Investigator
  
  Yabushita Yasuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Yokohama City University
Liver regeneration after associating liver partition and portal vein occlusion for staged hepatectomy
- Principal Investigator
  
  Tanaka Kuniya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Yokohama City University
  Teikyo University
Proteomic analysis of stromal tissue of pancreas
- Principal Investigator
  
  ENDO Itaru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Yokohama City University
Color-coded intravital imaging demonstrates a transforming growth factor B antagonist selectively targets stromal cells in a human pancreatic-cancer orthotopic mouse modelPrincipal Investigator
- Principal Investigator
  
  HIROSHIMA Yukihiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Yokohama City University
Cancer stem cell in colorectal liver metastasis
- Principal Investigator
  
  TANAKA Kuniya
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Yokohama City University
Proteomic analysis targeting stroma of pancreatic cancer
- Principal Investigator
  
  ENDO Itaru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Yokohama City University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation Other

[Journal Article] Reduction of gender‐associated M2‐like tumor‐associated macrophages in the tumor microenvironment of patients with pancreatic cancer after neoadjuvant chemoradiotherapy2021
- Author(s)
  Matsuki Hiroki、Hiroshima Yukihiko、Miyake Kentaro、Murakami Takashi、Homma Yuki、Matsuyama Ryusei、Morioka Daisuke、Kurotaki Daisuke、Tamura Tomohiko、Endo Itaru
- Journal Title
  
  Journal of Hepato-Biliary-Pancreatic Sciences
  
  Volume: 28 Issue: 2 Pages: 174-182
- DOI
  10.1002/jhbp.883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07670
[Journal Article] Novel targets identified by integrated cancer-stromal interactome analysis of pancreatic adenocarcinoma.2020
- Author(s)
  Hiroshima Y, Kasajima R, Kimura Y, Komura D, Ishikawa S, Ichikawa Y, Bouvet M, Yamamoto N, Oshima T, Morinaga S, Singh SR, Hoffman RM, Endo I, Miyagi Y.
- Journal Title
  
  Cancer Lett.
  
  Volume: 469 Pages: 217-227
- DOI
  10.1016/j.canlet.2019.10.031
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02481, KAKENHI-PROJECT-17H04992, KAKENHI-PROJECT-19K09181, KAKENHI-PROJECT-19H03774
[Journal Article] Impact of associating liver partition and portal vein occlusion for staged hepatectomy on tumor growth in a mouse model of liver metastasis.2018
- Author(s)
  Kikuchi Y, Hiroshima Y, Matsuo K, Murakami T, Kawaguchi D, Kasahara K, Tanaka K.
- Journal Title
  
  Eur J Surg Oncol.
  
  Volume: 44 Issue: 1 Pages: 130-138
- DOI
  10.1016/j.ejso.2017.11.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10582
[Journal Article] Tumor-Targeting Salmonella typhimurium A1-R Promotes Tumoricidal CD8+ T Cell Tumor Infiltration and Arrests Growth and Metastasis in a Syngeneic Pancreatic-Cancer Orthotopic Mouse Model.2018
- Author(s)
  Murakami T, Hiroshima Y, Zhang Y, Zhao M, Kiyuna T, Hwang HK, Miyake K, Homma Y, Mori R, Matsuyama R, Chishima T, Ichikawa Y, Tanaka K, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  J Cell Biochem.
  
  Volume: 119 Issue: 1 Pages: 634-639
- DOI
  10.1002/jcb.26224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10582
[Journal Article] Color-coded intravital imaging demonstrates a transforming growth factor-β (TGF-β) antagonist selectively targets stromal cells in a human pancreatic-cancer orthotopic mouse model.2017
- Author(s)
  Murakami T, Hiroshima Y, Miyake K, Hwang HK, Kiyuna T, DeLong JC, Lwin TM, Matsuyama R, Mori R, Kumamoto T, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  Cell Cycle
  
  Volume: 25 Issue: 10 Pages: 1-7
- DOI
  10.1080/15384101.2017.1315489
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26830081
[Journal Article] Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.2017
- Author(s)
  Murakami T, Li S, Han Q, Tan Y, Kiyuna T, Igarashi K, Kawaguchi K, Hwang HK, Miyake K, Singh AS, Nelson SD, Dry SM, Li Y, Hiroshima Y, Lwin TM, DeLong JC, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM.
- Journal Title
  
  Oncotarget
  
  Volume: Epub ahead of print Issue: 22 Pages: 35630-35638
- DOI
  10.18632/oncotarget.15823
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26830081
[Journal Article] Modified ALPPS Procedures Avoiding Division of Portal Pedicles.2017
- Author(s)
  Tanaka K, Kikuchi Y, Kawaguchi D, Murakami T, Hiroshima Y, Matsuo K.
- Journal Title
  
  Ann Surgery
  
  Volume: 265 Issue: 2 Pages: e14-e20
- DOI
  10.1097/sla.0000000000001967
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10582
[Journal Article] Modified Liver Hanging Maneuver for En-bloc Right-sided Hepatectomy Combined with Total Caudate Lobectomy for Colon-Cancer Liver Metastasis and Hepatocellular Carcinoma.2016
- Author(s)
  Hiroshima Y, Matsuo K, Kawaguchi D, Kikuchi Y, Endo I, Koda K, Togo S, Hoffman RM, Tanaka K.
- Journal Title
  
  Anticancer Res.
  
  Volume: 36 Pages: 1729-1735
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070
[Journal Article] Caerulein-induced pancreatitis augments the expression and phosphorylation of collapsin response mediator protein 4.2016
- Author(s)
  Sato S, Nakamura F, Hiroshima Y, Nagashima Y, Kato I, Yamashita N, Goshima Y, Endo I
- Journal Title
  
  J Hepatobiliary Pancreat Sci
  
  Volume: 23 Issue: 7 Pages: 422-431
- DOI
  10.1002/jhbp.361
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460456, KAKENHI-PROJECT-26462070, KAKENHI-PROJECT-16K07062
[Journal Article] Effective fluorescence-guided surgery of liver metastasis using a fluorescent anti-CEA antibody.2016
- Author(s)
  Hiroshima Y, Lwin TM, Murakami T, Mawy AA, Kuniya T, Chishima T, Endo I, Clary BM, Hoffman RM, Bouvet M.
- Journal Title
  
  J Surg Oncol.
  
  Volume: 114 Issue: 8 Pages: 951-958
- DOI
  10.1002/jso.24462
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070, KAKENHI-PROJECT-26830081
[Journal Article] Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy.2016
- Author(s)
  Hiroshima Y, Maawy A, Zhang Y, Zhang N, Murakami T, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  Oncotarget
  
  Volume: 7 Pages: 71696-71702
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26830081
[Journal Article] Patient-derived mouse models of cancer need to be orthotopic in order to evaluate targeted anti-metastatic therapy.2016
- Author(s)
  Hiroshima Y, Maawy A, Zhang Y, Zhang N, Murakami T, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  Oncotarget.
  
  Volume: 7 Issue: 44 Pages: 71696-71702
- DOI
  10.18632/oncotarget.12322
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070
[Journal Article] Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model.2016
- Author(s)
  Murakami T, Singh AS, Kiyuna T, Dry SM, Li Y, James AW, Igarashi K, Kawaguchi K, DeLong JC, Zhang Y, Hiroshima Y, Russell T, Eckardt MA, Yanagawa J, Federman N, Matsuyama R, Chishima T, Tanaka K, Bouvet M, Endo I, Eilber FC, Hoffman RM.
- Journal Title
  
  Oncotarget.
  
  Volume: 7 Issue: 30 Pages: 47556-47564
- DOI
  10.18632/oncotarget.9879
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070
[Journal Article] Tumor-Targeting Salmonella typhimurium A1-R Arrests a Chemo-Resistant Patient Soft-Tissue Sarcoma in Nude Mice.2015
- Author(s)
  Hiroshima Y, Zhao M, Zhang Y, Zhang N, Maawy A, Murakami T, Mii S, Uehara F, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 8 Pages: e0134324-e0134324
- DOI
  10.1371/journal.pone.0134324
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070, KAKENHI-PROJECT-26830081, KAKENHI-PROJECT-24592009
[Journal Article] Therapeutic efficacy of tumor-targeting Salmonella typhimurium A1-R on human colorectal cancer liver metastasis in orthotopic nude-mouse models.2015
- Author(s)
  Murakami T, Hiroshima Y, Zhao M, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  Oncotarget
  
  Volume: 6 Issue: 31 Pages: 31368-31377
- DOI
  10.18632/oncotarget.5187
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070, KAKENHI-PROJECT-26830081, KAKENHI-PROJECT-24592009
[Journal Article] Selective efficacy of zoledronic acid on metastasis in a patient-derived orthotopic xenograph (PDOX) nude-mouse model of human pancreatic cancer.2015
- Author(s)
  Hiroshima Y, Maawy AA, Katz MH, Fleming JB, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  J Surg Oncol.
  
  Volume: 111(3) Issue: 3 Pages: 311-5
- DOI
  10.1002/jso.23816
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462070, KAKENHI-PROJECT-26830081
[Journal Article] Establishment of a patient-derived orthotopic Xenograft (PDOX) model of HER-2-positive cervical cancer expressing the clinical metastatic pattern.2015
- Author(s)
  Hiroshima Y, Zhang Y, Zhang N, Maawy A, Mii S, Yamamoto M, Uehara F, Miwa S, Yano S, Murakami T, Momiyama M, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Murata T, Endo I, Hoffman RM.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 2 Pages: e0117417-e0117417
- DOI
  10.1371/journal.pone.0117417
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830081
[Journal Article] Fluorescence-Guided Surgery of Liver Metastasis in Orthotopic Nude-Mouse Models.2015
- Author(s)
  Murakami T, Hiroshima Y, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 10 Pages: e0138752-e0138752
- DOI
  10.1371/journal.pone.0138752
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070, KAKENHI-PROJECT-26830081, KAKENHI-PROJECT-24592009
[Journal Article] Tumor-Targeting Salmonella typhimurium A1-R in Combination with Trastuzumab Eradicates HER-2-Positive Cervical Cancer Cells in Patient-Derived Mouse Models.2015
- Author(s)
  Hiroshima Y, Zhang Y, Zhao M, Zhang N, Murakami T, Maawy A, Mii S, Uehara F, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 6 Pages: e0120358-e0120358
- DOI
  10.1371/journal.pone.0120358
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830081
[Journal Article] Patient-derived orthotopic xenograft (PDOX) nude mouse model of soft-tissue sarcoma more closely mimics the patient behavior in contrast to the subcutaneous ectopic model.2015
- Author(s)
  Hiroshima Y, Zhang Y, Zhang N, Uehara F, Maawy A, Murakami T, Mii S, Yamamoto M, Miwa S, Yano S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  Anticancer Res.
  
  Volume: 35 Pages: 697-701
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830081
[Journal Article] Improved disease-free survival and overall survival after fluorescence-guided surgery of liver metastasis in an orthotopic nude mouse model.2015
- Author(s)
  Murakami T, Hiroshima Y, Zhang Y, Bouvet M, Chishima T, Tanaka K, Endo I, Hoffman RM.
- Journal Title
  
  J Surg Oncol.
  
  Volume: 112 Issue: 2 Pages: 119-124
- DOI
  10.1002/jso.23986
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070, KAKENHI-PROJECT-26830081
[Journal Article] Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model.2015
- Author(s)
  Murakami T, Hiroshima Y, Zhao M, Zhang Y, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  Oncotarget
  
  Volume: 6 Issue: 39 Pages: 41856-41862
- DOI
  10.18632/oncotarget.6170
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070, KAKENHI-PROJECT-26830081, KAKENHI-PROJECT-24592009
[Journal Article] Photoimmunotherapy Inhibits Tumor Recurrence After Surgical Resection on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model.2015
- Author(s)
  Hiroshima Y, Maawy A, Zhang Y, Guzman MG, Heim R, Makings L, Luiken GA, Kobayashi H, Tanaka K, Endo I, Hoffman RM, Bouvet M.
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 22 Issue: S3 Pages: 1469-1474
- DOI
  10.1245/s10434-015-4553-9
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830081
[Journal Article] Fluorescence-guided surgery, but not bright-light surgery, prevents local recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) model resistant to neoadjuvant chemotherapy (NAC).2015
- Author(s)
  Hiroshima Y, Maawy A, Zhang Y, Murakami T, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Endo I, Hoffman RM, Bouvet M.
- Journal Title
  
  Pancreatology
  
  Volume: 15 Issue: 3 Pages: 295-301
- DOI
  10.1016/j.pan.2015.02.008
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830081
[Journal Article] Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models.2014
- Author(s)
  Hiroshima Y, Zhang Y, Murakami T, Maawy A, Miwa S, Yamamoto M, Yano S, Sato S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Zhao M, Hoffman RM.
- Journal Title
  
  Oncotarget.
  
  Volume: 15;5(23). Pages: 12346-57
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462070
[Journal Article] Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models.2014
- Author(s)
  Hiroshima Y, Zhang Y, Murakami T, Maawy A, Miwa S, Yamamoto M, Yano S, Sato S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Zhao M, Hoffman RM.
- Journal Title
  
  Oncotarget
  
  Volume: 15;5(23) Pages: 12346-57
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592009
[Journal Article] The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid.2014
- Author(s)
  Hiroshima Y, Maawy A, Hassanein MK, Menen R, Momiyama M, Murakami T, Miwa S, Yamamoto M, Uehara F, Yano S, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  PLoS One.
  
  Volume: 12;9(8) Issue: 8 Pages: e103382-e103382
- DOI
  10.1371/journal.pone.0103382
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592009, KAKENHI-PROJECT-26462070, KAKENHI-PROJECT-26830081
[Journal Article] Fluorescence-guided surgery in combination with UVC irradiation cures metastatic human pancreatic cancer in orthotopic mouse models.2014
- Author(s)
  Hiroshima Y, Maawy A, Zhang Y, Sato S, Murakami T, Yamamoto M, Uehara F, Miwa S, Yano S, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  PLoS One.
  
  Volume: 12;9(6) Issue: 6 Pages: e99977-e99977
- DOI
  10.1371/journal.pone.0099977
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592009, KAKENHI-PROJECT-26830081
[Journal Article] Metastatic Recurrence in a Pancreatic Cancer Patient Derived Orthotopic Xenograft (PDOX) Nude Mouse Model Is Inhibited by Neoadjuvant Chemotherapy in Combination with Fluorescence-Guided Surgery with an Anti-CA 19-9-Conjugated Fluorophore.2014
- Author(s)
  Hiroshima Y, Maawy A, Zhang Y, Murakami T, Momiyama M, Mori R, Matsuyama R, Katz MH, Fleming JB, Chishima T, Tanaka K, Ichikawa Y, Endo I, Hoffman RM, Bouvet M.
- Journal Title
  
  PLoS One.
  
  Volume: 2;9(12) Issue: 12 Pages: e114310-e114310
- DOI
  10.1371/journal.pone.0114310
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462070, KAKENHI-PROJECT-26830081
[Journal Article] Hand-held high-resolution fluorescence imaging system for fluorescence-guided surgery of patient and cell-line pancreatic tumors growing orthotopically in nude mice.2014
- Author(s)
  Hiroshima Y, Maawy A, Sato S, Murakami T, Uehara F, Miwa S, Yano S, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  J Surg Res.
  
  Volume: 187(2) Issue: 2 Pages: 510-7
- DOI
  10.1016/j.jss.2013.11.1083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592018
[Journal Article] Successful fluorescence-guided surgery on human colon cancer patient-derived orthotopic xenograft mouse models using a fluorophore-conjugated anti-CEA antibody and a portable imaging system.2014
- Author(s)
  Hiroshima Y, Maawy A, Metildi CA, Zhang Y, Uehara F, Miwa S, Yano S, Sato S, Murakami T, Momiyama M, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  J Laparoendosc Adv Surg Tech A.
  
  Volume: 24(4) Issue: 4 Pages: 241-7
- DOI
  10.1089/lap.2013.0418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592018, KAKENHI-PROJECT-24592009, KAKENHI-PROJECT-26462070
[Journal Article] Efficacy of Salmonella typhimurium A1-R Versus Chemotherapy on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX).2014
- Author(s)
  Hiroshima Y, Zhao M, Maawy A, Zhang Y, Katz MH, Fleming JB, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  J Cell Biochem
  
  Volume: 115(7) Issue: 7 Pages: 1254-61
- DOI
  10.1002/jcb.24769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592018, KAKENHI-PROJECT-24592009, KAKENHI-PROJECT-24890081, KAKENHI-PROJECT-26460997, KAKENHI-PROJECT-26462070, KAKENHI-PROJECT-26830081
[Journal Article] Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models.2014
- Author(s)
  Hiroshima Y, Zhang Y, Murakami T, Maawy A, Miwa S, Yamamoto M, Yano S, Sato S, Momiyama M, Mori R, Matsuyama R, Chishima T, Tanaka K, Ichikawa Y, Bouvet M, Endo I, Zhao M, Hoffman RM.
- Journal Title
  
  Oncotarget.
  
  Volume: 15;5(23) Pages: 12346-57
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26830081
[Journal Article] Comparison of efficacy of Salmonella typhimurium A1-R and chemotherapy on stem-like and non-stem human pancreatic cancer cells.2013
- Author(s)
  Hiroshima Y, Zhao M, Zhang Y, Maawy A, Hassanein MK, Uehara F, Miwa S, Yano S, Momiyama M, Suetsugu A, Chishima T, Tanaka K, Bouvet M, Endo I, Hoffman RM.
- Journal Title
  
  Cell Cycle
  
  Volume: 1;12(17) Issue: 17 Pages: 2774-80
- DOI
  10.4161/cc.25872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592018, KAKENHI-PROJECT-24890081
[Journal Article] Collapsin response mediator protein 4 expression is associated with liver metastasis and poor survival in pancreatic cancer2013
- Author(s)
  Hiroshima Y, Nagashima Y et al
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 20 (Suppl 3) Issue: S3 Pages: 369-378
- DOI
  10.1245/s10434-012-2491-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590429, KAKENHI-PROJECT-23592018, KAKENHI-PROJECT-24500443
[Journal Article] Hand-Held High-Resolution Fluorescence Imaging System for Fluorescence-Guided Surgery of Patient and Cell-Line Pancreatic Tumors Growing Orthotopically in Nude Mice2013
- Author(s)
  Yukihiko Hiroshima, Ali Maawy, Sho Sato, Takashi Murakami, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo and Robert M. Hoffman
- Journal Title
  
  J Surg Res.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592018
[Journal Article] Successful fluorescence-guided surgery on human colon cancer patient-derived orthotopic xenograft (PDOX) mouse models using a fluorophore-conjugated anti-CEA antibody and a portable imaging system2013
- Author(s)
  Yukihiko Hiroshima, Ali Maawy, Cristina A. Metildi, Yong Zhang, Fuminari Uehara, Shinji Miwa, Shuya Yano, Sho Sato, Takashi Murakami, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo and Robert M. Hoffman
- Journal Title
  
  J Laparoendosc Adv Surg Tech A.
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592018
[Journal Article] Collapsin Response Mediator Protein 4 Expression is Associated with Liver Metastasis and Poor Survival in Pancreatic Cancer.2012
- Author(s)
  Hiroshima Yukihiko
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] 膵癌における予後不良因子としてのNFAT familyの検討2022
- Author(s)
  上岡祐人，廣島幸彦，河原慎之輔，村川正明，山本直人，玉川洋，大島貴，宮城洋平，利野靖，森永聡一郎
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09181
[Presentation] Impact of Nuclear Factor of Activated T-cells (NFAT) families as a poor prognostic factor in pancreatic cancer patients.2022
- Author(s)
  Yuto Kamioka, Yukihiko Hiroshima, Shinnosuke Kawahara, Masaaki Murakawa, Naoto Yamamoto, Hiroshi Tamagawa, Takashi Oshima, Yohei Miyagi, Yasushi Rino, Soichiro Morinaga
- Organizer
  ASCO-GI
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09181
[Presentation] NFAT family contributes to early recurrence in pancreatic ductal adenocarcinoma2020
- Author(s)
  廣島幸彦、笠島理加、大津敬、宮城洋平.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09181
[Presentation] Impact of comprehensive cancer-stromal interactome analysis in pancreatic cancer2019
- Author(s)
  Yukihiko Hiroshima, Rika Kasajima, Yayoi Kimura, Daisuke Komura, Shumpei Ishikawa, Yasushi Ichikawa, Itaru Endo, and Yohei Miyagi
- Organizer
  第78回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K09181
[Presentation] Transforming growth factor-beta (TGF-β) inhibitor modulates cancer stroma in a pancreatic cancer orthotopic mouse model2017
- Author(s)
  Takashi Murakami, Yukihiko Hiroshima, Kentaro Miyake, Tasuku Kiyuna, Ho Kyoung Hwang, Kei Kawaguchi, Jonathan C. DeLong, Thinzer M. Lwin, Kentaro Igarashi, Ryusei Matsuyama, Ryutaro Mori, Takafumi Kumamoto, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman.
- Organizer
  AACR Annual Meeting 2017
- Place of Presentation
  Washington, D.C., USA
- Year and Date
  2017-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830081
[Presentation] 動物モデルを用いたALLPSにおける肝再生のメカニズムの解明と腫瘍増殖への影響の検討2016
- Author(s)
  菊地祐太郎、廣島幸彦、川口大輔、村上　崇、松尾憲一、田中邦哉
- Organizer
  第24回日本消化器関連学会週間（JDDW2016）
- Place of Presentation
  兵庫
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-16K10582
[Presentation] Tumor-targeting Salmonella typhimurium A1-R efficacy on colon cancer liver metastasis alone and in combination with fluorescence-guided surgery2016
- Author(s)
  Takashi Murakami, Yukihiko Hiroshima, Yong Zhang, Ming Zhao, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, MIchael Bouvet, Itaru Endo, Robert M. Hoffman.
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830081
[Presentation] Remnant liver tumor growth activity during associating liver partition and portal vein ligation for staged hepatectomy (ALLPS)2016
- Author(s)
  Kikuchi Y, Hiroshima Y, Matsuo K, Murakami T, Kawaguchi D, Koda K, Yamazaki K, Ishida Y, Togo S, Tanaka K
- Organizer
  7th International Forum of Liver Surgery Osaka 2016
- Place of Presentation
  大阪
- Year and Date
  2016-04-10
- Data Source
  KAKENHI-PROJECT-16K10582
[Presentation] The relationship between pancreatic cancer and phosphorylation mechanism of CRMP42016
- Author(s)
  Keiichi Y, Nakamura F, Sato S, Hiroshima Y, Goshima Y, Endo I
- Organizer
  IAP/JPS/AOPA joint meeting 2016
- Place of Presentation
  Sendai International Center (Miyagi)
- Year and Date
  2016-08-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070
[Presentation] Tumor-targeting Salmonella typhimurium A1-R promotes CD8+ T cell infiltration in pancreatic cancer in an orthotopic syngeneic mouse model2016
- Author(s)
  Takashi Murakami, Yukihiko Hiroshima, Yong Zhang, Ming Zhao, Tasuku Kiyuna, Ryusei Matsuyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman.
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830081
[Presentation] Histologic features after surgery associating liver partition and portal vein ligation for staged hepatectomy (ALLPS) vs. those following hepatectomy with portal vein embolization2016
- Author(s)
  Matsuo K, Murakami T, Kawaguchi D, Hiroshima Y, Koda K, Yamazaki K, Ishida Y, Tanaka K
- Organizer
  7th International Forum of Liver Surgery Osaka 2016
- Place of Presentation
  大阪
- Year and Date
  2016-04-10
- Data Source
  KAKENHI-PROJECT-16K10582
[Presentation] Curative fluorescence-guided surgery of pancreatic cancer in combination with UVC irradiation in orthotopic mouse models2015
- Author(s)
  Yukihiko Hiroshima, Ali Maawy, Yong Zhang, Sho Sato, Takashi Murakami, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
- Organizer
  AACR
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24592009
[Presentation] Efficacy of photo-immunotherapy in combination with surgical resection on a pancreatic cancer patient derived orthotopic xenograft (PDOX)2015
- Author(s)
  Yukihiko Hiroshima, Ali Maawy, Yong Zhang, Sho Sato, Takashi Murakami, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
- Organizer
  AACR
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830081
[Presentation] Curative fluorescence-guided surgery of pancreatic cancer in combination with UVC irradiation in orthotopic mouse models2015
- Author(s)
  Yukihiko Hiroshima, Ali Maawy, Yong Zhang, Sho Sato, Takashi Murakami, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
- Organizer
  AACR
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070
[Presentation] Curative fluorescence-guided surgery of pancreatic cancer in combination with UVC irradiation in orthotopic mouse models2015
- Author(s)
  Yukihiko Hiroshima, Ali Maawy, Yong Zhang, Sho Sato, Takashi Murakami, Mako Yamamoto, Fuminari Uehara, Shinji Miwa, Shuya Yano, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
- Organizer
  AACR
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26830081
[Presentation] Fluorescence-guided surgery of liver metastasis in orthotopic nude-mouse models2015
- Author(s)
  Takashi Murakami, Yukihiko Hiroshima, Shinji Miwa, Shuya Yano, Makoto Toneri, Mako Yamamoto, Masashi Momiyama, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
- Organizer
  AACR
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462070
[Presentation] The correlation between the change of future liver remnant volume and functional capacity in ALPPS (associating liver partition and portal vein ligation for staged hepatectomy), and establishment of ALPPS model in rats2015
- Author(s)
  Kawaguchi Daisuke, Yukihiko Hiroshima, Takashi Murakami, Kenichi Matsuo, Chihiro Kosugi, Kiyohiko Syuto, Masashi Momiyama, Itaru Endo, Keiji Koda, Kuniya Tanaka
- Organizer
  AACR
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24592009
[Presentation] Establishment of a patient-derived orthotopic xenograft (PDOX) model of patient cervical cancer2014
- Author(s)
  Yukihiko Hiroshima1, Yong Zhang1, Ali Maawy2, Sho Sato3, Takashi Murakami3, Mako Yamamoto1, Fuminari Uehara1, Shinji Miwa1, Shuya Yano1, Masashi Momiyama3, Takashi Chishima3, Kuniya Tanaka3, Ali Maawy2, Itaru Endo3, Robert M. Hoffman1.
- Organizer
  AACR
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Zoledronic acid inhibits proliferation and metastasis of human pancreatic cancer in the patient-derived orthotopic xenograft (PDOX) model by targeting tumor-educated macrophages2014
- Author(s)
  Yukihiko Hiroshima1, Mohamed K. Hassenein1, Rhiana Menen1, Matthew H.g. Katz2, Jason B. Fleming2, Sho Sato3, Takashi Murakami3, Mako Yamamoto1, Fuminari Uehara1, Shinji Miwa1, Shuya Yano1, Masashi Momiyama3, Ali Maawy4, Takashi Chishima3, Kuniya Tanaka3, Michael Bouvet4, Itaru Endo3, Robert M. Hoffman1.
- Organizer
  AACR
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Efficacy of Salmonella typhimurium A1-R and anti-VEGF therapy on a patient-derived orthotopic xenograft (PDOX) pancreatic cancer model2014
- Author(s)
  Yukihiko Hiroshima1, Ming Zhao1, Matthew H.G. Katz2, Jason B. Fleming2, Sho Sato3, Takashi Murakami3, Mako Yamamoto1, Fuminari Uehara1, Shinji Miwa1, Shuya Yano1, Masashi Momiyama3, Yong Zhang1, Ali Maawy4, Takashi Chishima3, Kuniya Tanaka3, Michael Bouvet4, Itaru Endo3, Robert M. Hoffman1.
- Organizer
  AACR
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] The advantages of patient-derived orthotopic xenograft (PDOX) of metastatic cervical cancer for individualized therapy compared to the PDX model2014
- Author(s)
  Yukihiko Hiroshima1, Yong Zhang1, Ali Maawy2, Sho Sato3, Takashi Murakami3, Mako Yamamoto1, Fuminari Uehara1, Shinji Miwa1, Shuya Yano1, Masashi Momiyama3, Takashi Chishima3, Kuniya Tanaka3, Michael Bouvet2, Itaru Endo3, Robert M. Hoffman1.
- Organizer
  AACR
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Efficacy of neoadjuvant chemotherapy in combination with fluorescence-guided surgery on a pancreatic cancer patient-derived orthotopic xenograft (PDOX)2014
- Author(s)
  Yukihiko Hiroshima1, Ali Maawy1, Yong Zhang1, Sho Sato2, Takashi Murakami2, Mako Yamamoto1, Fuminari Uehara1, Shinji Miwa1, Shuya Yano1, Masashi Momiyama2, Takashi Chishima2, Kuniya Tanaka2, Michael Bouvet3, Itaru Endo2, Robert M. Hoffman1.
- Organizer
  AACR
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] UVC irradiation in combination with fluorescence-guided surgery cures metastatic human pancreatic cancer in orthotopic mouse models2014
- Author(s)
  Yukihiko Hiroshima1, Ali Maawy2, Sho Sato3, Takashi Murakami3, Mako Yamamoto1, Fuminari Uehara1, Shinji Miwa1, Shuya Yano1, Masashi Momiyama3, Takashi Chishima3, Kuniya Tanaka3, Michael Bouvet4, Itaru Endo3, Robert M. Hoffman1.
- Organizer
  AACR
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Tumor-educated macrophages promote proliferation of human pancreatic cancer cells in vitro and in vivo2013
- Author(s)
  Yukihiko Hiroshima, Masashi Momiyama, Mohamed Hassanein, Ali Maawy, Rhiana Menen, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
- Organizer
  AACR annual meeting
- Place of Presentation
  Washington, DC
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Fluorescence-guided surgery for human-patient colon cancer tumorgrafts using a fluorophore-conjugated anti-CEA antibody2013
- Author(s)
  Hiroshima Yukihiko
- Organizer
  AACR annual meeting
- Place of Presentation
  U.S.A., Washington, DC
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Efficacy of Salmonella typhimurium A1-R on chemoresistant stem-like human pancreatic cancer cells2013
- Author(s)
  Hiroshima Yukihiko
- Organizer
  AACR annual meeting
- Place of Presentation
  U.S.A., Washington, DC
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Salmonella typhimurium A1-R targets chemoresistant stem-like human pancreatic cancer cells2013
- Author(s)
  Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Ali Maawy, Mohamed K. Hassanein, Atsushi Suetsugu, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
- Organizer
  ASCO annual meeting
- Place of Presentation
  Chicago, IL
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Efficacy of Salmonella typhimurium A1-R on chemoresistant stem-like human pancreatic cancer cells2013
- Author(s)
  Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Ali Maawy, Mohamed Hassanein, Atsushi Suetsugu, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
- Organizer
  AACR annual meeting
- Place of Presentation
  Washington, DC
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Tumor-educated macrophages promote proliferation of human pancreatic cancer cells in vitro and in vivo2013
- Author(s)
  Hiroshima Yukihiko
- Organizer
  AACR annual meeting
- Place of Presentation
  U.S.A., Washington, DC
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Efficacy of Salmonella typhimurium A1-R treatment on human patient pancreatic tumorgrafts2013
- Author(s)
  Yukihiko Hiroshima, Ming Zhao, Matthew H.G. Katz, Jason B. Fleming, Atsushi Suetsugu, Yong Zhang, Ali Maawy, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
- Organizer
  AACR annual meeting
- Place of Presentation
  Washington, DC
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Salmonella typhimurium A1-R effectively targets human-patient pancreatic tumorgrafts in nude mice2013
- Author(s)
  Ming Zhao, Matthew H. G. Katz, Jason B. Fleming, Atsushi Suetsugu, Yong Zhang, Ali Maawy, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman, Yukihiko Hiroshima
- Organizer
  ASCO annual meeting
- Place of Presentation
  Chicago, IL
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Fluorescence-guided surgery for human-patient colon cancer tumorgrafts using a fluorophore-conjugated anti-CEA antibody2013
- Author(s)
  Yukihiko Hiroshima, Ali Maawy, Yong Zhang, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo, Robert M. Hoffman
- Organizer
  AACR annual meeting
- Place of Presentation
  Washington, DC
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Efficacy of Salmonella typhimurium A1-R treatment on human patient pancreatic tumorgrafts2013
- Author(s)
  Hiroshima Yukihiko
- Organizer
  AACR annual meeting
- Place of Presentation
  U.S.A., Washington, DC
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Collapsin response mediator protein 4 promotes tumor cell invasion and lethality of pancreatic cancer2012
- Author(s)
  Yukihiko Hiroshima, Fumio Nakamura, Hiroshi Miyamoto, Ryutaro Mori, Koichi Taniguchi, Ryusei Matsuyama, Kazuhisa Takeda, Hirotoshi Akiyama, Kuniya Tanaka, Yasushi Ichikawa, Yoji Nagashima, Yoshio Goshima, Itaru Endo
- Organizer
  AACR annual meeting
- Place of Presentation
  Chicago, IL
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Collapsin Response Mediator Protein 4 Promotes Tumor Cell Invasion and Lethality of Pancreatic Cancer2012
- Author(s)
  廣島　幸彦
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  アメリカ、シカゴ
- Data Source
  KAKENHI-PROJECT-23592018
[Presentation] Fluorescence-guided surgery with an anti-CA 19-9-conjugated fluorophore in combination with neoadjuvant chemotherapy inhibits metastatic recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) nude mouse model
- Author(s)
  Yukihiko Hiroshima1, Ali Maawy2, Yong Zhang3, Takashi Murakami4, Masashi Momiyama4, Ryutaro Mori4, Ryusei Matsuyama4, Matthew H. Katz5, Jason B. Fleming5, Takashi Chishima4, Kuniya Tanaka4, Yasushi ichikawa4, Itaru Endo4, Robert M. Hoffman6, Michael Bouvet
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-26830081
[Presentation] Curative fluorescence-guided surgery of pancreatic cancer in combination with UVC irradiation in orthotopic mouse models
- Author(s)
  Yukihiko Hiroshima1, Ali Maawy2, Yong Zhang1, Sho Sato3, Takashi Murakami1, Mako Yamamoto1, Fuminari Uehara1, Shinji Miwa1, Shuya Yano1, Masashi Momiyama3, Takashi Chishima3, Kuniya Tanaka3, Michael Bouvet2, Itaru Endo3, Robert M. Hoffman
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-26830081
[Presentation] Curative fluorescence-guided surgery of pancreatic cancer in combination with UVC irradiation in orthotopic mouse models
- Author(s)
  Yukihiko Hiroshima1, Ali Maawy2, Yong Zhang1, Sho Sato3, Takashi Murakami1, Mako Yamamoto1, Fuminari Uehara1, Shinji Miwa1, Shuya Yano1, Masashi Momiyama3, Takashi Chishima3, Kuniya Tanaka3, Michael Bouvet2, Itaru Endo3, Robert M. Hoffman2.
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-19 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-24592009
[Presentation] Fluorescence-guided surgery with an anti-CA 19-9-conjugated fluorophore in combination with neoadjuvant chemotherapy inhibits metastatic recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) nude mouse model
- Author(s)
  Yukihiko Hiroshima1, Ali Maawy2, Yong Zhang3, Takashi Murakami4, Masashi Momiyama4, Ryutaro Mori4, Ryusei Matsuyama4, Matthew H. Katz5, Jason B. Fleming5, Takashi Chishima4, Kuniya Tanaka4, Yasushi ichikawa4, Itaru Endo4, Robert M. Hoffman6, Michael Bouvet2.
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-26462070
[Presentation] Fluorescence-guided surgery with an anti-CA 19-9-conjugated fluorophore in combination with neoadjuvant chemotherapy inhibits metastatic recurrence in a pancreatic cancer patient derived orthotopic xenograft (PDOX) nude mouse model
- Author(s)
  Yukihiko Hiroshima1, Ali Maawy2, Yong Zhang3, Takashi Murakami4, Masashi Momiyama4, Ryutaro Mori4, Ryusei Matsuyama4, Matthew H. Katz5, Jason B. Fleming5, Takashi Chishima4, Kuniya Tanaka4, Yasushi ichikawa4, Itaru Endo4, Robert M. Hoffman6, Michael Bouvet2.
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-19 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-24592009
[Presentation] luorescence-guided surgery of liver metastasis in orthotopic nude-mouse models
- Author(s)
  Takashi Murakami1, Yukihiko Hiroshima1, Shinji Miwa1, Yano Shuya1, Makoto Toneri1, Mako Yamamoto1, Masashi Momiyama2, Takashi Chishima2, Kuniya Tanaka2, Michael Bouvet1, Satoshi Hasegawa2, Itaru Endo2, Robert M. Hoffman
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-26830081
[Presentation] Efficacy of photo-immunotherapy in combination with surgical resection on a pancreatic cancer patient derived orthotopic xenograft (PDOX)
- Author(s)
  Yukihiko Hiroshima1, Ali Maawy2, Takashi Murakami1, Nzola De Magalhães2, Daisuke Kawaguchi3, Kenichi Matsuo3, Kuniya Tanaka3, Michael Bouvet2, Robert M. Hoffman2, Itaru Endo1.
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-26462070
[Presentation] The correlation between the change of future remnant liver volume and functional capacity in ALPPS (associating liver partition and portal vein ligation for staged hepatectomy), and establishment of ALPPS model in rats
- Author(s)
  Daisuke Kawaguchi1, Yukihiko Hiroshima1, Takashi Murakami1, Kenichi Matsuo1, Chihiro Kosugi1, Kiyohiko Syuto1, Akimitsu Yamada2, Itaru Endo2, Keiji Koda1, Kuniya Tanaka
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-26830081
[Presentation] Fluorescence-guided surgery of liver metastasis in orthotopic nude-mouse models
- Author(s)
  Takashi Murakami1, Yukihiko Hiroshima1, Shinji Miwa1, Yano Shuya1, Makoto Toneri1, Mako Yamamoto1, Masashi Momiyama2, Takashi Chishima2, Kuniya Tanaka2, Michael Bouvet1, Satoshi Hasegawa2, Itaru Endo2, Robert M. Hoffman3.
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-19 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-24592009
[Presentation] The correlation between the change of future remnant liver volume and functional capacity in ALPPS (associating liver partition and portal vein ligation for staged hepatectomy), and establishment of ALPPS model in rats
- Author(s)
  Daisuke Kawaguchi1, Yukihiko Hiroshima1, Takashi Murakami1, Kenichi Matsuo1, Chihiro Kosugi1, Kiyohiko Syuto1, Akimitsu Yamada2, Itaru Endo2, Keiji Koda1, Kuniya Tanaka1.
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-19 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-24592009
[Presentation] Efficacy of photo-immunotherapy in combination with surgical resection on a pancreatic cancer patient derived orthotopic xenograft (PDOX)
- Author(s)
  Yukihiko Hiroshima1, Ali Maawy2, Takashi Murakami1, Nzola De Magalhães2, Daisuke Kawaguchi3, Kenichi Matsuo3, Kuniya Tanaka3, Michael Bouvet2, Robert M. Hoffman2, Itaru Endo1.
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-19 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-24592009
[Presentation] Efficacy of photo-immunotherapy in combination with surgical resection on a pancreatic cancer patient derived orthotopic xenograft (PDOX)
- Author(s)
  Yukihiko Hiroshima1, Ali Maawy2, Takashi Murakami1, Nzola De Magalhães2, Daisuke Kawaguchi3, Kenichi Matsuo3, Kuniya Tanaka3, Michael Bouvet2, Robert M. Hoffman2, Itaru Endo1.
- Organizer
  米国癌学会（AACR annual meeting 2015）
- Place of Presentation
  Philadelphia、米国
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-26830081
[]
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[]

1. ENDO Itaru (60211091)

# of Collaborated Projects: 4 results

# of Collaborated Products: 37 results
2. HIRANO Hisashi (00275075)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MORI Ryutaro (90596412)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. TANAKA Kuniya (10295503)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
5. 黒滝大翼 (10568455)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Yabushita Yasuhiro (80614693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Kasajima Rika (20630875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. miyagi yohei (00254194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 松尾憲一 (10363839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
10. 松山隆生 (30464548)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 本間祐樹 (60567618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 井元清哉 (10345027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山口類 (90380675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 森永聡一郎 (80244432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 長嶋洋治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 石川俊平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hiroshima Yukihiko 廣島 幸彦

HIROSHIMA Yukihiko 廣島 幸彦

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エピゲノム解析を用いたサブタイプ別の膵癌-間質相互作用マスター制御因子の探索Principal Investigator

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Discovering tumor microenvironment of pancreatic cancerPrincipal Investigator

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Color-coded intravital imaging demonstrates a transforming growth factor B antagonist selectively targets stromal cells in a human pancreatic-cancer orthotopic mouse modelPrincipal Investigator

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[Journal Article] Reduction of gender‐associated M2‐like tumor‐associated macrophages in the tumor microenvironment of patients with pancreatic cancer after neoadjuvant chemoradiotherapy2021

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[Journal Article] Novel targets identified by integrated cancer-stromal interactome analysis of pancreatic adenocarcinoma.2020

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[Journal Article] Impact of associating liver partition and portal vein occlusion for staged hepatectomy on tumor growth in a mouse model of liver metastasis.2018

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[Journal Article] Tumor-Targeting Salmonella typhimurium A1-R Promotes Tumoricidal CD8+ T Cell Tumor Infiltration and Arrests Growth and Metastasis in a Syngeneic Pancreatic-Cancer Orthotopic Mouse Model.2018

Author(s)

Hiroshima Yukihiko 廣島幸彦

HIROSHIMA Yukihiko 廣島幸彦