Ohtsuki Gen 大槻元

… Alternative Names

大槻元オオツキゲン

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Researcher Number	60723278
Other IDs	https://orcid.org/0000-0003-3004-5886
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定教授
Affiliation (based on the past Project Information) *help	2023: 京都大学, 医学研究科, 特定教授 2020 – 2021: 京都大学, 医学研究科, 特定教授 2017: 京都大学, 白眉センター, 特定准教授 2015 – 2016: 京都大学, 学内共同利用施設等, 准教授 2014: 九州大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Basic Section 46010:Neuroscience-general-related / Neurophysiology / General neuroscience Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator 免疫誘導型可塑性 / 精神疾患 / 発達期社会敗北ストレス / 妊娠期母体免疫活性化 / 学習障害 / 内因性興奮性可塑性 / シナプス可塑性 / 小脳 / 精神疾患モデル / 複合炎症ストレス … More / 4細胞同時パッチクランプ記録 / 3次元位置機能解析 / 多細胞同時パッチクランプ / 大脳皮質一次視覚野 / ３次元位置機能解析 / 機能発達 / 細胞位置機能解析 / 生体下Ca2+イメージング / 一次視覚野 / 大脳皮質 / 遺伝子改変マウス / クローン細胞 … More Except Principal Investigator 分子メカニズム / 社交性 / アンヘドニア / エピジェネティクス / 個体差 / レジリエンス / ストレス脆弱性 / うつ病 / 神経回路 / ストレス / 精神疾患 / 脳内炎症 / マウスモデル / 思春期 / 社会性ストレス Less

複合炎症精神疾患モデルマウスの小脳機能低下の神経生理学的機序解明Principal Investigator
- Principal Investigator
  
  大槻元
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Kyoto University
心の健康増進をめざしたストレス感受性の生物学的基盤の解明
- Principal Investigator
  
  内田周作
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nagoya City University
  Kyoto University
Dimensional approaches to psychiatric disorders associated with circuit abnormalities induced by genetic and environmental insults combined with inflammation in the brain
- Principal Investigator
  
  Sakurai Takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Kyoto University
Analysis of the functional development of clonally-related neurons in the visual cortexPrincipal Investigator
- Principal Investigator
  
  Ohtsuki Gen
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  Kyoto University
  Kyushu University

All 2024 2023 2022 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons2024
- Author(s)
  Kawatake-Kuno Ayako、Li Haiyan、Inaba Hiromichi、Hikosaka Momoka、Ishimori Erina、Ueki Takatoshi、Garkun Yury、Morishita Hirofumi、Narumiya Shuh、Oishi Naoya、Ohtsuki Gen、Murai Toshiya、Uchida Shusaku
- Journal Title
  
  Neuron
  
  Volume: Feb 19 Issue: 8 Pages: 00049-7
- DOI
  10.1016/j.neuron.2024.01.023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K05978, KAKENHI-PROJECT-21K07593, KAKENHI-PROJECT-23K21413, KAKENHI-PROJECT-23K24789
[Journal Article] Editorial: Cerebellum-related learning and psychiatric diseases2023
- Author(s)
  Ohtsuki Gen、Kim Taegon、Sun Peng、Chen Yongjun、Ugo D'Angelo Egidio
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 13;17 Pages: 1132286-1132286
- DOI
  10.3389/fncel.2023.1132286
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K05978
[Journal Article] Environmental stress insults in 2HIT model synergistically produce disorder-associated microglia and macrophages in the cerebellum2023
- Author(s)
  Yamawaki Yuki、Parvez Md Sorwer Alam、Wada Yayoi、Oe Souichi、Hirahara Yukie、Koike Taro、Hikosaka Momoka、Kumagai Asuka、Matsui Sae、Sakurai Takeshi、Kitada Masaaki、Narumiya Shuh、Ohtsuki Gen
- Journal Title
  
  Research Square
  
  Volume: posted 21 Feb.
- DOI
  10.21203/rs.3.rs-2555653/v1
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K05978
[Journal Article] Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex2022
- Author(s)
  Yamawaki Yuki、Wada Yayoi、Matsui Sae、Ohtsuki Gen
- Journal Title
  
  Current Research in Neurobiology
  
  Volume: 3 Pages: 100028-100028
- DOI
  10.1016/j.crneur.2022.100028
- NAID
  120007191373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03547
[Journal Article] Synaptic Potential and Plasticity of an SK2 Channel Gate Regulate Spike Burst Activity in Cerebellar Purkinje Cells2018
- Author(s)
  Ohtsuki Gen、Hansel Christian
- Journal Title
  
  iScience
  
  Volume: 1 Pages: 49-54
- DOI
  10.1016/j.isci.2018.02.001
- NAID
  120006719402
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710002
[Journal Article] Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells.2016
- Author(s)
  Grasselli G, He Q, Wan V, Adelman JP, Ohtsuki G, Hansel C.
- Journal Title
  
  Cell Reports
  
  Volume: 14 Issue: 11 Pages: 2546-2553
- DOI
  10.1016/j.celrep.2016.02.054
- NAID
  120005829371
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710002
[Journal Article] The Spontaneous Ataxic Mouse Mutant Tippy is Characterized by a Novel Purkinje Cell Morphogenesis and Degeneration Phenotype.2015
- Author(s)
  Shih EK, Sekerková G, Ohtsuki G, Aldinger KA, Chizhikov VV, Hansel C, Mugnaini E, Millen KJ.
- Journal Title
  
  Cerebellum
  
  Volume: 14 Issue: 3 Pages: 292-307
- DOI
  10.1007/s12311-014-0640-x
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710002
[Presentation] Environmental stress insults in 2HIT model synergistically produce disorder-associated microglia and macrophages in the cerebellum2023
- Author(s)
  大槻元
- Organizer
  第46回日本神経科学大会シンポジウム口演
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K05978
[Presentation] Impairments of synaptic transmission and plasticity in the cerebellum of psychiatric disorder mouse models via developmental complex inflammatory stress2023
- Author(s)
  Momoka Hikosaka, Nobutake Hosoi, Yuki Yamawaki, and Gen Ohtsuki
- Organizer
  第46回日本神経科学大会ポスター発表
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K05978
[Presentation] Environmental stress insults in 2HIT model synergistically produce reactive microglia including DAMIMCs in the cerebellum2023
- Author(s)
  Gen Ohtsuki
- Organizer
  京都大学第3回研究交流サロンポスター発表
- Data Source
  KAKENHI-PROJECT-23K05978
[Presentation] Induction mechanism for the bacterial endotoxin-triggered excitability plasticity in cerebellar Purkinje neurons through microglia.2017
- Author(s)
  大槻　元
- Organizer
  第40回日本神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710002
[Presentation] Bacterial endotoxin induces excitability plasticity in cerebellar Purkinje neurons2017
- Author(s)
  Gen Ohtsuki
- Organizer
  the Cell Symposium: Neuro-Immune Axis: Reciprocal Regulation in Development, Health, & Disease.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710002
[Presentation] Functional Diversification in Clonal Cells after Eye-Opening in Mouse Visual Cortex2015
- Author(s)
  Gen Ohtsuki
- Organizer
  Mini-symposium:　　Wiring and Plasticity in the Brain
- Place of Presentation
  京都大学　大学院理学研究科
- Year and Date
  2015-07-24
- Invited
- Data Source
  KAKENHI-PROJECT-26710002
[Presentation] Functional Diversification in Clonal Cells after Eye-Opening in Mouse Visual Cortex.2015
- Author(s)
  Gen Ohtsuki, Carlos Lois, and Kenichi Ohki
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場、神戸国際展示場
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26710002
[Presentation] Inside of the head.2015
- Author(s)
  Gen Ohtsuki
- Organizer
  白眉セミナー
- Place of Presentation
  京都大学　白眉センター
- Year and Date
  2015-11-10
- Data Source
  KAKENHI-PROJECT-26710002

1. Sakurai Takeshi (90615717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 内田周作 (10403669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. OHKI Kenichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Ohtsuki Gen 大槻 元

大槻 元 オオツキ ゲン

Research Projects

Research Products

Co-Researchers

複合炎症精神疾患モデルマウスの小脳機能低下の神経生理学的機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

心の健康増進をめざしたストレス感受性の生物学的基盤の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dimensional approaches to psychiatric disorders associated with circuit abnormalities induced by genetic and environmental insults combined with inflammation in the brain

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the functional development of clonally-related neurons in the visual cortexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Editorial: Cerebellum-related learning and psychiatric diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Environmental stress insults in 2HIT model synergistically produce disorder-associated microglia and macrophages in the cerebellum2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex2022

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Synaptic Potential and Plasticity of an SK2 Channel Gate Regulate Spike Burst Activity in Cerebellar Purkinje Cells2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] The Spontaneous Ataxic Mouse Mutant Tippy is Characterized by a Novel Purkinje Cell Morphogenesis and Degeneration Phenotype.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Environmental stress insults in 2HIT model synergistically produce disorder-associated microglia and macrophages in the cerebellum2023

Author(s)

Organizer

Data Source

[Presentation] Impairments of synaptic transmission and plasticity in the cerebellum of psychiatric disorder mouse models via developmental complex inflammatory stress2023

Author(s)

Organizer

Data Source

[Presentation] Environmental stress insults in 2HIT model synergistically produce reactive microglia including DAMIMCs in the cerebellum2023

Author(s)

Organizer

Data Source

[Presentation] Induction mechanism for the bacterial endotoxin-triggered excitability plasticity in cerebellar Purkinje neurons through microglia.2017

Ohtsuki Gen 大槻元

大槻元オオツキゲン