Ajiro Masahiko 網代将彦

Researcher Number	60761864
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 研究所, 主任研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人国立がん研究センター, 研究所, 主任研究員 2021 – 2022: 京都大学, 医学研究科, 特定講師 2019 – 2020: 京都大学, 医学研究科, 特定助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 48040:Medical biochemistry-related Except Principal Investigator Broad Section H / Chemical biology
Keywords	Principal Investigator RNAスプライシング / SRSF2 / SF3B1 / スプライシング異常 / ネオ抗原 / TCR-T / がん免疫 / 選択的スプライシング / CLK / 深部イントロン … More / SRSF / スプライシング / 人工知能 / CLK阻害剤 / 家族性自律神経異常症 / 嚢胞性線維症 / がん / 偽エクソン / アンチセンス核酸薬 / 低分子化合物 / 疾患モデル動物 / スプライシング変異 / スプライシング抗原 / RNAバイオロジー / 病原性スプライシング / 遺伝病 / 癌免疫 … More Except Principal Investigator スプライシング / RNAプロセシング / 液－液相分離 / RNA結合蚕白質 / SRタンパク質 / 病的液-液相分離 / 転写 / RNA ポリメラーゼII / SRタンパク / 病的液-液相分 / iPS / CRISPR / kibans / トランスクリプトーム / RNA病モデル / モデルトランスクリプトーム解析 / トランスクリプトーム解析 / RNA病 / スプライシング介入ルール / 遺伝子性疾患 / ポストゲノム創薬 / スプライシング制御 / 遺伝性疾患 Less

Cancer immune therapeutics targeting aberrant RNA splicing productsPrincipal Investigator
- Principal Investigator
  
  網代将彦
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  National Cancer Center Japan
Synthetic investigation of pathological phase separation of RNA-binding proteins
- Principal Investigator
  
  萩原正敏
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section H
- Research Institution
  Kyoto University
Functional study for CLK-dependent pseudo exon in genetic diseasesPrincipal Investigator
- Principal Investigator
  
  Ajiro Masahiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal Models
- Principal Investigator
  
  Hagiwara Masatoshi
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book Patent

[Book] 実験医学2023年8月号／スプライスネオ抗原誘導によるがん免疫療法の展開2023
- Author(s)
  網代将彦
- Total Pages
  133
- Publisher
  羊土社
- ISBN
  9784758125703
- Data Source
  KAKENHI-PROJECT-23K27379
[Book] スプライシング疾患の低分子創薬に向けて―家族性自律神経失調症に対する候補化合物RECTAS (Drug development targeting splicing diseases―Therapeutic potential of RECTAS for familial dysautonomia)（「医学のあゆみ」誌2022
- Author(s)
  網代将彦、萩原正敏
- Total Pages
  2
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-19K07367
[Book] 月刊メディカル・サイエンス・ダイジェスト　8月号 Vol.46 No.9 2020 通巻610号2020
- Author(s)
  網代将彦、萩原正敏
- Total Pages
  57
- Publisher
  ニュー・サイエンス社
- Data Source
  KAKENHI-PROJECT-15H05721
[Journal Article] Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration2024
- Author(s)
  Mamiko Yamada, Kazuhiro Maeta, Hisato Suzuki, Ryo Kurosawa, Toshiki Takenouchi, Tomonari Awaya , Masahiko Ajiro , Atsuko Takeuchi, Hisahide Nishio , Masatoshi Hagiwara , Fuyuki Miya, Masafumi Matsuo, Kenjiro Kosaki
- Journal Title
  
  Sci Rep .
  
  Volume: - Issue: 1 Pages: 6506-6506
- DOI
  10.1038/s41598-024-56704-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15873, KAKENHI-PROJECT-22KJ2023, KAKENHI-PROJECT-21K07762, KAKENHI-PROJECT-23K27379
[Journal Article] Tertiary lymphoid structure and neutrophil?lymphocyte ratio coordinately predict outcome of pembrolizumab2023
- Author(s)
  Komura K,Tokushige S, Ishida M, Hirosuna K,Yamazaki S,Nishimura K,Ajiro M,Ohno T,Nakamori K,Kinoshita S,Tsujino T, Maenosono R,Yoshikawa Y, Takai T, Tsutsumi T,Taniguchi K,Tanaka T,Takahara K, Inamoto T,Hirose Y, Ono F,Shiraishi Y,Yoshimi A,Azuma H.
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 12 Pages: 4622-31
- DOI
  10.1111/cas.15976
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09386, KAKENHI-PROJECT-21H04828, KAKENHI-PROJECT-23K21471, KAKENHI-PROJECT-23K27379
[Journal Article] Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy2023
- Author(s)
  Sakamoto Tetsunori、Ajiro Masahiko、Watanabe Akira、Matsushima Shingo、Ueda Keiji、Hagiwara Masatoshi
- Journal Title
  
  BMC Cancer
  
  Volume: 23 Issue: 1 Pages: 20-23
- DOI
  10.1186/s12885-023-10540-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H05042
[Journal Article] The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer2023
- Author(s)
  Komura K, Hirosuna K, Tokushige S, Nishimura K, Ishida M, Hayashi T, Ura A, Ohno T, Yamazaki S, Nakamori K, Kinoshita S, Tsujino T, Maenosono R, Ajiro M, Yoshikawa Y, Takai T, Tsutsumi T, Taniguchi K, Tanaka T, Takahara K, Konuma T, Inamoto T, Hirose Y, Ono F, Shiraishi Y, Yoshimi A#, Azuma H.
- Journal Title
  
  Molecular Cancer
  
  Volume: 22 Issue: 1 Pages: 185-185
- DOI
  10.1186/s12943-023-01897-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K17431, KAKENHI-PROJECT-21K09386, KAKENHI-PROJECT-21H04828, KAKENHI-PROJECT-23K21471, KAKENHI-PROJECT-23K27379
[Journal Article] PDIVAS: Pathogenicity predictor for Deep-Intronic Variants causing Aberrant Splicing2023
- Author(s)
  Kurosawa Ryo、Iida Kei、Ajiro Masahiko、Awaya Tomonari、Yamada Mamiko、Kosaki Kenjiro、Hagiwara Masatoshi
- Journal Title
  
  BMC Genomics
  
  Volume: 24 Issue: 1 Pages: 601-601
- DOI
  10.1186/s12864-023-09645-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KJ2023, KAKENHI-PROJECT-23K27379
[Journal Article] Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer2022
- Author(s)
  Matsushima Shingo、Ajiro Masahiko、Iida Kei、Chamoto Kenji、Honjo Tasuku、Hagiwara Masatoshi
- Journal Title
  
  Science Translational Medicine
  
  Volume: 14 Issue: 673 Pages: 30-14
- DOI
  10.1126/scitranslmed.abn6056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07310, KAKENHI-PROJECT-21H05042
[Journal Article] Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia2021
- Author(s)
  Masahiko Ajiro, Tomonari Awaya, Young Jin Kim, Kei Iida, Masatsugu Denawa, Nobuo Tanaka, Ryo Kurosawa, Shingo Matsushima, Saiko Shibata, Tetsunori Sakamoto, Rolenz Studer, Adrian R. Krainer, and Masatoshi Hagiwara
- Journal Title
  
  Nature Communications
  
  Volume: in press
- NAID
  120007141965
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07367
[Journal Article] Switching of OAS1 splicing isoforms mitigates SARS-CoV-2 infection2021
- Author(s)
  Iida Kei、Ajiro Masahiko、Muramoto Yukiko、Takenaga Toru、Denawa Masatsugu、Kurosawa Ryo、Noda Takeshi、Hagiwara Masatoshi
- Journal Title
  
  BioRXiv
  
  Volume: -
- DOI
  10.1101/2021.08.23.457314
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07367, KAKENHI-PROJECT-20K07310
[Journal Article] CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer2021
- Author(s)
  Simon Uzor, Sean R Porazinski, Ling Li, Bethany Clark, Masahiko Ajiro, Kei Iida, Masatoshi Hagiwara, Abdullah A Alqasem, Claire M Perks, Ian D Wilson, Sebastian Oltean, and Michael R Ladomery
- Journal Title
  
  Scientific Reports
  
  Volume: 11(1) Issue: 1 Pages: 7963-7963
- DOI
  10.1038/s41598-021-86908-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07367
[Journal Article] Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia2021
- Author(s)
  Ajiro Masahiko、Awaya Tomonari、Kim Young Jin、Iida Kei、Denawa Masatsugu、Tanaka Nobuo、Kurosawa Ryo、Matsushima Shingo、Shibata Saiko、Sakamoto Tetsunori、Studer Lorenz、Krainer Adrian R.、Hagiwara Masatoshi
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4507-4507
- DOI
  10.1038/s41467-021-24705-5
- NAID
  120007141965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07367
[Journal Article] RNAスプライシング異常を標的とした創薬展開/Drug Development by Targeting Aberrant RNA Splicing2020
- Author(s)
  網代将彦、萩原正敏
- Journal Title
  
  Medical Science Digest
  
  Volume: 46(9) Pages: 550-554
- Data Source
  KAKENHI-PROJECT-19K07367
[Journal Article] Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion2020
- Author(s)
  Saiko Shibata, Masahiko Ajiro (#), and Masatoshi Hagiwara (#)
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 27(12) Issue: 12 Pages: 1472-1482
- DOI
  10.1016/j.chembiol.2020.08.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07367, KAKENHI-PROJECT-15H05721
[Journal Article] Oncogenic splicing factor SRSF3 regulates ILF3 alternative splicing to promote cancer cell proliferation and transformation2019
- Author(s)
  Rong Jia, Masahiko Ajiro, Lulu Yu, Philip McCoy Jr. and Zhi-Ming Zheng
- Journal Title
  
  RNA
  
  Volume: 25 Issue: 5 Pages: 630-644
- DOI
  10.1261/rna.068619.118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07367
[Journal Article] ―スプライシング応答の可視化― スプライシング変異から挑むプレシジョンメディシン2019
- Author(s)
  網代将彦
- Journal Title
  
  Precission Medicine
  
  Volume: 2 Pages: 483-486
- Data Source
  KAKENHI-PROJECT-19K07367
[Journal Article] CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia2018
- Author(s)
  Ajiro Masahiko、Sakai Hiroyuki、Onogi Hiroshi、Yamamoto Makoto、Sumi Eriko、Sawada Teruo、Nomura Takashi、Kabashima Kenji、Hosoya Takamitsu、Hagiwara Masatoshi
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 24 Issue: 18 Pages: 4518-4528
- DOI
  10.1158/1078-0432.ccr-17-3119
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06414, KAKENHI-PROJECT-15H05721
[Journal Article] Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency2018
- Author(s)
  Boisson Bertrand、Honda Yoshitaka、Ajiro Masahiko、Bustamante Jacinta、Bendavid Matthieu、Gennery Andrew R.、Kawasaki Yuri、Ichishima Jose、Osawa Mitsujiro、Nihira Hiroshi、Shiba Takeshi、Tanaka Takayuki、Chrabieh Maya、Bigio Benedetta、Hur Hong、Itan Yuval、Liang Yupu、Okada Satoshi、et al.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 129 Issue: 2 Pages: 583-597
- DOI
  10.1172/jci124011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0228, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-16H05352, KAKENHI-PROJECT-16H05355, KAKENHI-PROJECT-17J08574, KAKENHI-PROJECT-19K07367
[Journal Article] Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression.2017
- Author(s)
  Ngoc NB, Okuno Y, Ajiro M, Iida K, Denawa M, Yamamoto M, Sakamoto N, Kagechika H, Hagiwara M
- Journal Title
  
  J Med Virol
  
  Volume: Epub ahead of print Issue: 7 Pages: 1224-1234
- DOI
  10.1002/jmv.24739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05282, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-16K15420
[Patent] 含窒素複素環化合物2022
- Inventor(s)
  萩原正敏　網代将彦　松島慎吾
- Industrial Property Rights Holder
  国立大学法人　京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-144961
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21H05042
[Patent] キナゾリン誘導体2022
- Inventor(s)
  萩原正敏　粟屋智就　網代将彦　五反田健徳
- Industrial Property Rights Holder
  国立大学法人　京都大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-178402
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21H05042
[Patent] スプライシング制御化合物による腫瘍免疫原性の向上2021
- Inventor(s)
  萩原正敏　網代将彦　松島慎吾
- Industrial Property Rights Holder
  萩原正敏　網代将彦　松島慎吾
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-144961
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21H05042
[Patent] ヒトパピローマウイルスの排除方法2019
- Inventor(s)
  萩原正敏、網代将彦、小野木博
- Industrial Property Rights Holder
  萩原正敏、網代将彦、小野木博
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K07367
[Patent] ウイルスを原因とする腫瘍を抑制する医薬組成物2019
- Inventor(s)
  萩原正敏、網代将彦、阪本哲紀
- Industrial Property Rights Holder
  萩原正敏、網代将彦、阪本哲紀
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K07367
[Patent] アルツハイマー病のための医薬組成物2019
- Inventor(s)
  萩原正敏、網代将彦
- Industrial Property Rights Holder
  萩原正敏、網代将彦
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K07367
[Patent] PHARMACEUTICAL COMPOSITION AND TREATMENT METHOD FOR GENETIC DISEASE ASSOCIATED WITH SPLICING ABNORMALITIES2019
- Inventor(s)
  萩原正敏、網代将彦
- Industrial Property Rights Holder
  萩原正敏、網代将彦
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Investigation of dysregulated RNA splicing for cancer immunity2023
- Author(s)
  Masahiko Ajiro, Shingo Matsushima, Kei Iida, Kazuki Nishimura, Kazumasa Komura, Haruhito Azuma, Masatoshi Hagiwara, and Akihide Yoshimi
- Organizer
  第24回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-23K27379
[Presentation] Cancer immunotherapy targeting aberrant RNA splicing regulation／RNAスプライシング異常を標的としたがん免疫治療2023
- Author(s)
  網代将彦、松島慎吾、飯田慶、西村一希、小村和正、東治人、萩原正敏、吉見昭秀
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K27379
[Presentation] Precision Medicine to Provide Resistance to SARS-CoV-2 Infection by Switching OAS1 Splicing Isoforms2021
- Author(s)
  Kei Iida, Masahiko Ajiro, Yukiko Muramoto, Toru Takenaga, Masatsugu Denawa, Ryo Kurosawa, Takeshi Noda, and Masatoshi Hagiwara
- Organizer
  Cold Spring Harbor Laboratory Eukaryotic mRNA Processing Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] A synonymous SCN5A variant p.E446E causing Brugada Syndrome via cryptic donor site splicing2021
- Author(s)
  Yuichi Sawayama, Koichi Kato, Masahiko Ajiro, Ryo Kurosawa, Seiko Ohno, Yoshihisa Nakagawa, Minoru Horie
- Organizer
  第85回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] New strategy for enhancing tumor immunity by splicing modulator-mediated splice-neoantigens2021
- Author(s)
  Shingo Matsushima, Masahiko Ajiro, Kei Iida, Kenji Chamoto, and Masatoshi Hagiwara
- Organizer
  京都大学発生細胞生物学システム生物学リトリート
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia2021
- Author(s)
  Masahiko Ajiro, Kei Iida, Tomonari Awaya, Krainer R. Adrian, and Masatoshi Hagiwara
- Organizer
  第22回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] 先天性QT延長症候群I型に対するスプライシング制御化合物の検討2021
- Author(s)
  牧ケ谷佳佑、牧山武、網代将彦、萩原正敏
- Organizer
  第７回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia2021
- Author(s)
  Masahiko Ajiro, Kei Iida, Tomonari Awaya, Krainer R. Adrian, and Masatoshi Hagiwara
- Organizer
  Cold Spring Harbor Laboratory Eukaryotic mRNA Processing Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Genome-wide Screening for Pseudo-exonic Variants and their Modulation by CLK Inhibitors2021
- Author(s)
  黒澤凌、網代将彦、萩原正敏
- Organizer
  京都大学医薬系研究交流サロン
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Comprehensive analysis of whole-genome sequence for deep-intronic splicing-associated variant2021
- Author(s)
  Ryo Kurosawa, Masahiko Ajiro, Kei Iida, Masatoshi Hagiwara
- Organizer
  第４４回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Boosted tumor immunogenicity by splicing modulation potentiates the response to immune checkpoint therapy2021
- Author(s)
  Shingo Matsushima, Masahiko Ajiro, Kenji Chamoto, Tasuku Honjo, Masatoshi Hagiwara
- Organizer
  第４４回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] 病原性深部イントロン変異の検出に向けたスクリーニング手法の検討2021
- Author(s)
  黒澤凌、網代将彦、飯田慶、粟屋智就、萩原正敏
- Organizer
  第７回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Precision Medicine to Provide Resistance to SARS-CoV-2 Infection by Switching OAS1 Splicing Isoforms2021
- Author(s)
  Kei Iida, Masahiko Ajiro, Yukiko Muramoto, Toru Takenaga, Masatsugu Denawa, Ryo Kurosawa, Takeshi Noda, Masatoshi Hagiwara
- Organizer
  第４４回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia2021
- Author(s)
  Masahiko Ajiro, Kei Iida, Tomonari Awaya, Krainer Adrian, Masatoshi Hagiwara
- Organizer
  第４４回日本分子生物学会年会ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] スプライシング標的化合物による筋疾患治療への挑戦2021
- Author(s)
  網代将彦、粟屋智就、萩原正敏
- Organizer
  第７回日本筋学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] スプライシング治療薬による遺伝病治療の試み2020
- Author(s)
  萩原正敏、伊藤慎二、網代将彦
- Organizer
  第45回日本医用マススペクトル学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] New strategy for enhancing tumor immunity by splicing modulator-mediated splice-neoantigens.2020
- Author(s)
  Shingo Matsushima, Masahiko Ajiro, Kei Iida, Kenji Chamoto, and Masatoshi Hagiwara
- Organizer
  京都大学発生細胞生物学システム生物学リトリート
- Invited
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Genome-wide Screening for Pseudo-exonic Variants and their Modulation by CLK Inhibitors2020
- Author(s)
  黒澤凌、網代将彦、萩原正敏
- Organizer
  京都大学メディカルイノベーション卓越大学院プログラム・医薬系研究交流サロン
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] 偽エクソン型スプライス変異の探索と化合物応答性評価/Investigation of pathogenic pseudo exons and their amendment by small molecules.2020
- Author(s)
  黒澤凌、網代将彦、萩原正敏
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Amending splicing defects by small molecule compounds/低分子化合物による病原性スプライシングの制御2020
- Author(s)
  Masahiko Ajiro, Masatoshi Hagiwara
- Organizer
  第43回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Application of Splice-Targeting Small Molecule Compounds for Pathogenic Pseudo Exons Caused by Deep-Intronic Mutations. 病原性深部イントロン変異に起因する偽エクソンを標的としたスプライシング制御化合物の検討2020
- Author(s)
  網代将彦、本田吉孝、八角高裕、萩原正敏
- Organizer
  京都大学メディカルイノベーション卓越大学院プログラム・医薬系研究交流サロン
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] CLK-SRSF経路の阻害による偽エクソン型スプライシング疾患の治療効果2020
- Author(s)
  網代将彦
- Organizer
  第21回　日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] 心ファブリー病に対するスプライシング制御化合物に関する研究開発2020
- Author(s)
  網代将彦、粟屋智就、田中信生、萩原正敏
- Organizer
  国立研究開発法人日本医療研究開発機構 2事業合同成果報告会「疾患克服への挑戦2019」
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] A synonymous SCN5A variant p.E446E causing Brugada Syndrome via cryptic donor site splicing2020
- Author(s)
  Yuichi Sawayama, Koichi Kato, Masahiko Ajiro, Ryo Kurosawa, Seiko Ohno, Yoshihisa Nakagawa, Minoru Horie
- Organizer
  第85回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] スプライシング異常を原因とする嚢胞性線維症に対する低分子治療薬の探索2019
- Author(s)
  柴田済子、網代将彦、萩原正敏
- Organizer
  第14回　日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Application of Splice-Targeting Small Molecule Compounds for Pathogenic Pseudo Exons Caused by Deep-Intronic Mutations2019
- Author(s)
  網代将彦、本田吉孝、八角高裕、萩原正敏
- Organizer
  京都大学メディカルイノベーション卓越大学院プログラム・医薬系研究交流サロン
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] 深部イントロン変異に起因する偽エクソンを標的としたCLK-SRSF経路阻害効果2019
- Author(s)
  網代将彦
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] Assessment of antiviral effect of FIT-039 against Kaposi’s sarcoma-associated herpesvirus.2019
- Author(s)
  Tetsunori Sakamoto, Masahiko Ajiro, Keiji Ueda, and Masatoshi Hagiwara
- Organizer
  世界をリードする次世代MD研究者・養成プロジェクト2019年度全国リトリート
- Invited
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] MTRR遺伝子偽エクソン型変異に対するCLK阻害化合物の検討2019
- Author(s)
  劉百香、網代将彦、萩原正敏
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Therapeutic effect of CLK inhibition for EDA-ID caused by the IVS4+866 C>T deep-intronic mutation of NEMO gene.2019
- Author(s)
  Masahiko Ajiro, Yoshitaka Honda, Jean Laurent Casanova, Takahiro Yasumi, and Masatoshi Hagiwara.
- Organizer
  Cold Spring Harbor Laboratory eukaryotic mRNA processing meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] Oncogenic role of splicing factor SRSF3 through ILF3 and targeting SR protein function by CLK inhibitor.2019
- Author(s)
  網代将彦、萩原正敏
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] NEMO異常症の偽エクソン型変異に対するCLKを標的とした治療戦略2019
- Author(s)
  網代将彦、本田吉孝、八角高祐、萩原正敏
- Organizer
  第14回　日本ケミカルバイオロジー学会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] 心ファブリー病に対するスプライシング制御化合物に関する研究開発2019
- Author(s)
  網代将彦、粟屋智就、田中信生、萩原正敏
- Organizer
  疾患克服への挑戦2019
- Invited
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] CLK-SRSF経路の阻害による偽エクソン型スプライシング疾患の治療効果2019
- Author(s)
  網代将彦
- Organizer
  第21回　日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] 深部イントロン変異に起因する偽エクソンを標的としたCLK-SRSF経路阻害効果2019
- Author(s)
  網代将彦、本田吉孝、八角高祐、萩原正敏
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07367
[Presentation] NEMO異常症の偽エクソン型変異に対するCLKを標的とした治療戦 CLK-targeting therapeutic strategy for NEMO-deficiency syndrome2019
- Author(s)
  網代将彦
- Organizer
  日本ケミカルバイオロジー学会第14回年会
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] Oncogenic role of splicing factor SRSF3 through ILF3 and targeting SR protein function by CLK inhibitor.2019
- Author(s)
  Masahiko Ajiro and Hagiwara Masatoshi
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] Therapeutic effect of CLK inhibition for EDA-ID caused by the IVS4+866 C>T deep-intronic mutation of NEMO gene2019
- Author(s)
  Masahiko Ajiro
- Organizer
  Cold Spring Harbor Meeting Eukaryotic mRNA Processing
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] CLK-SRSF経路の阻害による偽エクソン型スプライシング疾患の治療効果2019
- Author(s)
  網代将彦
- Organizer
  第21回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] Splicing therapy for cardiac Fabry Diseas2018
- Author(s)
  Masahiko Ajiro
- Organizer
  Cold Spring Harbor Asia Meeting RNA Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] CDK9 inhibitor FIT-039 suppresses viral oncogenes E6 and E7 with a therapeutic effect for HPV-induced neoplasia2018
- Author(s)
  Masahiko Ajiro
- Organizer
  International Chemical Biology Society (ICBS 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] CDK9 inhibitor FIT-039 suppresses viral oncogenes E6 and E7 and has therapeutic effect on HPV-induced neoplasia2018
- Author(s)
  Masahiko Ajiro
- Organizer
  WCP 2018 KYOTO 18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] Therapeutic effect of RECTAS for familial dysautonomia by activating SRSF6 on IKBKAP splicing enhancer2018
- Author(s)
  Masahiko Ajiro
- Organizer
  Cold Spring Harbor Asia Meeting RNA Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05721
[Presentation] SRSF6活性化によるIKBKAPスプライシング制御を介した家族性自律神経失調症に対するRECTASの治療効果検討 Therapeutic effect of RECTAS for familial dysautonomia by activating SRSF6 on IKBKAP splicing enhancer2018
- Author(s)
  網代将彦
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15H05721

1. Hagiwara Masatoshi (10208423)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 武内章英 (90436618)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 粟屋智就 (20589593)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 鶴山竜昭 (00303842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 奥野友紀子 (00372524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 飯田慶 (00387961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 大江賢治 (30419527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 細谷孝充 (60273124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 吉澤拓也 (50779056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 井上大地 (80735746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OKADA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. INAMOTO Teruo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 坂本直哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 東治人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 小野公二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 小村和正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 山田茉未子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 吉見昭秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ajiro Masahiko 網代 将彦

Research Projects

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Cancer immune therapeutics targeting aberrant RNA splicing productsPrincipal Investigator

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Synthetic investigation of pathological phase separation of RNA-binding proteins

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Functional study for CLK-dependent pseudo exon in genetic diseasesPrincipal Investigator

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Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal Models

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[Book] 実験医学2023年8月号／スプライスネオ抗原誘導によるがん免疫療法の展開2023

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[Book] スプライシング疾患の低分子創薬に向けて―家族性自律神経失調症に対する候補化合物RECTAS (Drug development targeting splicing diseases―Therapeutic potential of RECTAS for familial dysautonomia)（「医学のあゆみ」誌2022

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[Book] 月刊メディカル・サイエンス・ダイジェスト 8月号 Vol.46 No.9 2020 通巻610号2020

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[Journal Article] Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration2024

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[Journal Article] Tertiary lymphoid structure and neutrophil?lymphocyte ratio coordinately predict outcome of pembrolizumab2023

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[Journal Article] Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy2023

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[Journal Article] The Impact of FGFR3 Alterations on the Tumor Microenvironment and the Efficacy of Immune Checkpoint Inhibitors in Bladder Cancer2023

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[Journal Article] PDIVAS: Pathogenicity predictor for Deep-Intronic Variants causing Aberrant Splicing2023

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[Journal Article] Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer2022

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[Journal Article] Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia2021

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NAID

Data Source

[Journal Article] Switching of OAS1 splicing isoforms mitigates SARS-CoV-2 infection2021

Ajiro Masahiko 網代将彦

[Book] 月刊メディカル・サイエンス・ダイジェスト　8月号 Vol.46 No.9 2020 通巻610号2020