Tsukagoshi Mariko 塚越真梨子

Researcher Number	60781317
Other IDs
Affiliation (Current)	2025: 群馬大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 群馬大学, 大学院医学系研究科, 助教 2018 – 2023: 群馬大学, 大学院医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 癌微小環境 / サイトカイン / 肝癌 / 癌関連線維芽細胞 / GPR68 / コノフィリン / 肝星細胞 / 肝細胞癌 / 薬剤耐性 / Conophylline … More Except Principal Investigator … More OT-Iマウス / 抗原特異的疲弊化CD8T細胞 / 免疫治療耐性 / 骨格筋減少 / 免疫耐性獲得機構 / BCAA / Hepa1-6 / 肝癌 / 筋萎縮 / PGC-1α過剰発現マウス / シナジー効果 / 化学療法 / STMN1 / 温熱療法 / PIP化合物 / 膵癌 / STMN / 難治癌 / Vγ6γδ型T細胞 / IL-17産生γδ型Ｔ細胞 / 転移性肺腫瘍 / Vγ6陽性γδ型T細胞 / IL-17産生γδ型T細胞 / 腫瘍免疫 / 免疫チェックポイント分子 / 新規免疫チェックポイント分子 / 疲弊化CD8T細胞 / PGC-1αマウス / 肝筋連関 / 肝再生率 / PGC1αマウス / 肝筋相関 / 分岐鎖アミノ酸 / 肝切除 / 肝再生 / サルコペニア / Galectin 3阻害剤 / マウス皮下腫瘍モデル / 肝胆膵癌 / M2BPGi / 癌関連線維芽細胞 / 肝胆膵がん Less

酸性微小環境における肝癌細胞の応答機構の解明と新規治療戦略の開発Principal Investigator
- Principal Investigator
  
  塚越真梨子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
Impact of sarcopenia and creation of novel therapeutic targets by immunotherapeutic resistance mechanisms in hepatocellular carcinoma
- Principal Investigator
  
  新木健一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
STMN1を標的とした化学療法・温熱療法とのシナジーによる膵癌新規治療法の開発
- Principal Investigator
  
  渡辺亮
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma Institute of Public Health and Environmental Sciences
  Gunma University
Identification of novel immune check point molecules in exhausted CD8+ T cells
- Principal Investigator
  
  Yajima Toshiki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kagawa University
  Gunma University
Generation of novel cancer immune therapy by regulation of IL-17 producing gd T cells
- Principal Investigator
  
  Shirabe Ken
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Gunma University
Development of new therapeutic methods targeting cytokine regulators in cancer-related fibroblastsPrincipal Investigator
- Principal Investigator
  
  Tsukagoshi Mariko
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Gunma University
Evaluation of the effect of sarcopenia on liver regeneration from the viewpoint between liver and muscle correlation
- Principal Investigator
  
  Araki Kenichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
Development of innovative treatment targeting liver cancer associated fibroblastPrincipal Investigator
- Principal Investigator
  
  Tsukagoshi Mariko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
New humoral factor facilitates hepato-biliary and pancreatic cancer progression and development of innovative thrapy
- Principal Investigator
  
  Shirabe Ken
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis2021
- Author(s)
  Gantumur D, Harimoto N, Muranushi R, Hoshino K, Batbayar C, Hagiwara K, Yamanaka T, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Araki K, Yokobori T, Aishima S, Shirabe K.
- Journal Title
  
  Hepatol Res .
  
  Volume: Online ahead of print. Issue: 10 Pages: 1058-1063
- DOI
  10.1111/hepr.13648
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein-coupled Receptor 682021
- Author(s)
  Yamanaka T, Harimoto N, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, Gantumur D, Handa T, Ishii N, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Araki K, Umezawa K, Shirabe K.
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: Online ahead of print. Issue: 6 Pages: 1019-1028
- DOI
  10.1158/1535-7163.mct-20-0150
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-20K16352
[Journal Article] Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling2020
- Author(s)
  Dolgormaa Gantumur、Harimoto Norifumi、Ishii Norihiro、Yamanaka Takahiro、Hagiwara Kei、Tsukagoshi Mariko、Igarashi Takamichi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Handa Tadashi、Yokobori Takehiko、Oyama Tetsunari、Kuwano Hiroyuki、Shirabe Ken
- Journal Title
  
  British Journal of Cancer
  
  Volume: 123 Issue: 7 Pages: 1145-1153
- DOI
  10.1038/s41416-020-0971-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16199, KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-18K07665
[Journal Article] Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts2020
- Author(s)
  Yamanaka Takahiro、Harimoto Norifumi、Yokobori Takehiko、Muranushi Ryo、Hoshino Kouki、Hagiwara Kei、Gantumur Dolgormaa、Handa Tadashi、Ishii Norihiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Shirabe Ken
- Journal Title
  
  British Journal of Cancer
  
  Volume: 122 Issue: 7 Pages: 986-994
- DOI
  10.1038/s41416-020-0744-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02877, KAKENHI-PROJECT-20K16199
[Journal Article] Preoperative Mac‐2 binding protein glycosylation isomer level predicts postoperative ascites in patients with hepatic resection for hepatocellular carcinoma2019
- Author(s)
  Ishii Norihiro、Harimoto Norifumi、Araki Kenichiro、Muranushi Ryo、Hoshino Kouki、Hagiwara Kei、Gantumur Dolgormaa、Yamanaka Takahiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Shirabe Ken
- Journal Title
  
  Hepatology Research
  
  Volume: 49 Issue: 12 Pages: 1398-1405
- DOI
  10.1111/hepr.13412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02877
[Journal Article] High Co-expression of Large Tenascin C Splice Variants in Stromal Tissue and Annexin A2 in Cancer Cell Membranes is Associated with Poor Prognosis in Pancreatic Cancer2019
- Author(s)
  Hagiwara Kei、Harimoto Norifumi、Yokobori Takehiko、Muranushi Ryo、Hoshino Kouki、Gantumur Dorgormaa、Yamanaka Takahiro、Ishii Norihiro、Tsukagoshi Mariko、Igarashi Takamichi、Tanaka Hiroshi、Watanabe Akira、Kubo Norio、Araki Kenichiro、Hosouchi Yasuo、Shirabe Ken
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 27 Issue: 3 Pages: 924-930
- DOI
  10.1245/s10434-019-07708-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02877
[Presentation] 抗原特異的 CD8T 細胞の疲弊化誘導における各免疫チェックポイント分子の役割2022
- Author(s)
  村主　遼、矢島俊樹、星野弘毅、山中崇弘、萩原慶、塚越真梨子、石井範洋、渡辺亮、新木健一郎、播本憲史、調　憲
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] 抗 PD-1 抗体耐性メカニズムにおける疲弊化 CD8T 細胞での各免疫チェックポイント分子の役割2022
- Author(s)
  矢島　俊樹、村主遼、星野弘毅、吉川良平、大瀧容一、尾林海、中澤世識、河谷菜津子、矢澤友弘、塚越真梨子、調憲
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021
- Author(s)
  萩原慶、播本憲史、新木健一郎、久保憲生、渡辺亮、五十嵐隆通、塚越真梨子、石井範洋、星野弘毅、村主遼、調憲
- Organizer
  第121 回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09163
[Presentation] 抗原特異的CD8陽性T細胞の疲弊化誘導における各免疫チェックポイント分子の役割2021
- Author(s)
  村主　遼、矢島俊樹、星野弘毅、栗山健吾、塚越真梨子、山中崇弘、萩原慶、石井範洋、渡辺亮、新木健一郎、播本憲史、調　憲
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021
- Author(s)
  萩原慶、播本憲史、新木健一郎、久保憲生、渡辺亮、五十嵐隆通、塚越真梨子、石井範洋、星野弘毅、村主遼、調憲
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09163
[Presentation] 抗原特異的CD8Ｔ細胞誘導マウス腫瘍モデルを用いた動態解析2021
- Author(s)
  星野　弘毅、矢島俊樹、播本憲史、村主遼、萩原慶、山中崇弘、石井範洋、塚越真梨子、渡辺亮、新木健一郎、調　憲
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19518
[Presentation] 癌関連線維芽細胞が産生するサイトカインの制御に基づく，肝癌の新たな治療戦略2020
- Author(s)
  山中崇弘、播本憲史、村主遼、星野弘毅、萩原慶、石井範洋、塚越真梨子、五十嵐隆通、渡辺亮、久保憲生、新木健一郎、梅澤一夫、調憲
- Organizer
  第120回日本外科学会
- Data Source
  KAKENHI-PROJECT-18H02877

1. Shirabe Ken (70264025)

# of Collaborated Projects: 6 results

# of Collaborated Products: 12 results
2. Araki Kenichiro (60431706)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. 播本憲史 (00419582)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. Yajima Toshiki (20346852)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. 石井範洋 (00711508)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. 久保憲生 (10464744)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
7. 横堀武彦 (60420098)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. 渡辺亮 (60738847)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. 五十嵐隆通 (20648472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 市川聡 (60333621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大瀧容一 (00625402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 中澤世識 (60791978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 半田正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tsukagoshi Mariko 塚越 真梨子

Research Projects

Research Products

Co-Researchers

酸性微小環境における肝癌細胞の応答機構の解明と新規治療戦略の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impact of sarcopenia and creation of novel therapeutic targets by immunotherapeutic resistance mechanisms in hepatocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

STMN1を標的とした化学療法・温熱療法とのシナジーによる膵癌新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel immune check point molecules in exhausted CD8+ T cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of novel cancer immune therapy by regulation of IL-17 producing gd T cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new therapeutic methods targeting cytokine regulators in cancer-related fibroblastsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of the effect of sarcopenia on liver regeneration from the viewpoint between liver and muscle correlation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative treatment targeting liver cancer associated fibroblastPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New humoral factor facilitates hepato-biliary and pancreatic cancer progression and development of innovative thrapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Hepatic stellate cell as a Mac-2-binding protein-producing cell in patients with liver fibrosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conophylline Inhibits Hepatocellular Carcinoma by Inhibiting Activated Cancer-associated Fibroblasts Through Suppression of G Protein-coupled Receptor 682021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preoperative Mac‐2 binding protein glycosylation isomer level predicts postoperative ascites in patients with hepatic resection for hepatocellular carcinoma2019

Author(s)

Tsukagoshi Mariko 塚越真梨子

[Presentation] 抗原特異的 CD8T 細胞の疲弊化誘導における各免疫チェックポイント分子の役割2022

[Presentation] 抗 PD-1 抗体耐性メカニズムにおける疲弊化 CD8T 細胞での各免疫チェックポイント分子の役割2022

[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021

[Presentation] サルコペニアにおける肝切除後肝再生抑制に関する基礎的研究2021

[Presentation] 癌関連線維芽細胞が産生するサイトカインの制御に基づく，肝癌の新たな治療戦略2020