AKAMINE TAKAHIRO 赤嶺孝祐

Researcher Number	60799435
Other IDs
Affiliation (Current)	2025: 大分大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2019 – 2024: 大分大学, 医学部, 助教 2017 – 2018: 大分大学, 医学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Ophthalmology Except Principal Investigator Basic Section 56060:Ophthalmology-related / Basic Section 53040:Nephrology-related / Basic Section 53050:Dermatology-related / Basic Section 48010:Anatomy-related
Keywords	Principal Investigator ROCK / 血管透過性 / ARDS / メタボローム解析 / 血液網膜関門 / トランスポーター / 時間薬理学 / 眼科薬理学 Except Principal Investigator Wnt/β-catenin / 細胞外マトリックス … More / TGF-β / 網膜色素上皮細胞 / ROCK / アクチン細胞骨格 / 加齢 / 薬剤性腎障害 / Rho / 眼内増殖性疾患 / CBP/β-catenin / TGF-βシグナル伝達 / TGF- β2シグナル伝達 / TGF-β2シグナル伝達 / 網膜色素上皮 / 高深度DIAリン酸化プロテオーム解析 / Wnt/β-catenin経路 / 増殖硝子体網膜症 / TSLP / アトピー / 皮膚恒常性 / SWI/SNF / ケラチノサイト / アトピー性皮膚炎 / 慢性炎症性皮膚疾患 / 胃がん / 炎症 / CagA / 炎症性脂質メディエーター / ピロリ菌 Less

メタボローム解析から迫るROCK血管透過性調節機序解明とARDS治療への応用Principal Investigator
- Principal Investigator
  
  赤嶺孝祐
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Oita University
Role of Actin Regulator ROCK in Age-Related Exacerbation of Drug-Induced Renal Injury
- Principal Investigator
  
  石崎敏理
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Oita University
Wnt/β-catenin経路を標的とした眼内増殖性疾患の治療法の開発
- Principal Investigator
  
  木許賢一
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Oita University
Investigation of pulmonary vascular permeability based on the ROCK signalingPrincipal Investigator
- Principal Investigator
  
  Akamine Takahiro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Oita University
Development of foundation for ARDS treatment based on controlling vascular permeabilityPrincipal Investigator
- Principal Investigator
  
  Akamine Takahiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Oita University
Gastric carcinogenesis caused by Helicoobacter pylori-induced inflammation
- Principal Investigator
  
  Hamada Fumihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Oita University
Investigation of skin homeostasis based on the regulation of actin cytoskeleton
- Principal Investigator
  
  Terabayashi Takeshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Oita University
Inhibition of Wnt/beta-catenin to treat proliferative vitreoretinopathy
- Principal Investigator
  
  Kimoto Kenichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Oita University
Analysis of blood-retinal barrier based on circadian expression of drug transporters.Principal Investigator
- Principal Investigator
  
  AKAMINE TAKAHIRO
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Ophthalmology
- Research Institution
  Oita University

All 2024 2022 2021 2020 2018

All Journal Article Presentation

[Journal Article] Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice2024
- Author(s)
  Akamine Takahiro、Terabayashi Takeshi、Sasaki Takako、Hayashi Riku、Abe Ichitaro、Hirayama Fumihiro、Nureki Shin‐ichi、Ikawa Masahito、Miyata Haruhiko、Tokunaga Akinori、Kobayashi Takashi、Hanada Katsuhiro、Thumkeo Dean、Narumiya Shuh、Ishizaki Toshimasa
- Journal Title
  
  FEBS Open Bio
  
  Volume: - Issue: 6 Pages: 906-921
- DOI
  10.1002/2211-5463.13802
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08384, KAKENHI-PROJECT-23K06356, KAKENHI-PROJECT-22K16175
[Journal Article] Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene2018
- Author(s)
  Katamune Chiharu、Koyanagi Satoru、Hashikawa Ken-ichi、Kusunose Naoki、Akamine Takahiro、Matsunaga Naoya、Ohdo Shigehiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 2 Pages: 547-558
- DOI
  10.1074/jbc.ra118.004942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17H06976
[Journal Article] Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model2018
- Author(s)
  Akamine Takahiro、Kusunose Naoki、Matsunaga Naoya、Koyanagi Satoru、Ohdo Shigehiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Issue: 1 Pages: 181-187
- DOI
  10.1016/j.bbrc.2018.05.209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17H06976
[Journal Article] Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (M?ller) cells2018
- Author(s)
  Kusunose Naoki、Akamine Takahiro、Kobayashi Yoshiyuki、Yoshida Shigeo、Kimoto Kenichi、Yasukochi Sai、Matsunaga Naoya、Koyanagi Satoru、Ohdo Shigehiro、Kubota Toshiaki
- Journal Title
  
  Japanese Journal of Ophthalmology
  
  Volume: 62 Issue: 6 Pages: 677-685
- DOI
  10.1007/s10384-018-0622-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-17H06976
[Presentation] The ROCK signaling regulates the pulmonary vascular permeability via maintenance of lung homeostasis.2022
- Author(s)
  赤嶺孝祐、寺林健、佐々木隆子、石崎敏理
- Organizer
  第96回薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K17217
[Presentation] チモサポニンAIIIは乳がん細胞の形態可塑性と遊走能を阻害する2021
- Author(s)
  寺林健、花田克浩、松岡茂、赤嶺孝祐、石崎敏理
- Organizer
  第94回　日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K08776
[Presentation] ROCKシグナリングから迫る新規肺血管透過性制御機構の解明2021
- Author(s)
  赤嶺孝祐、寺林健、佐々木隆子、石崎敏理
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K17217
[Presentation] バイカレインは乳がん細胞の形態可塑性と細胞運動を抑制する2020
- Author(s)
  寺林健、花田克浩、赤嶺孝祐、石崎敏理
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K08776
[Presentation] アクチン重合促進因子mDia1は圧負荷心肥大応答を制御し心機能維持に寄与する2020
- Author(s)
  安部一太郎、寺林健、赤嶺孝祐、髙橋尚彦、石崎敏理
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K08776
[Presentation] The clock gene DEC2 contributes to VEGF upregulation by modulating HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Muller) cells.2018
- Author(s)
  Takahiro AKAMINE, Naoki KUSUNOSE, Yoshiyuki KOBAYASHI, Shigeo YOSHIDA, Naoya MATSUNAGA, Satoru KOYANAGI, Kenichi KIMOTO, Shigehiro OHDO, and Toshiaki KUBOTA
- Organizer
  The 11th Joint Meeting of Japan-China-Korea Ophthalmologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06976

1. Terabayashi Takeshi (40452429)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. Kimoto Kenichi (50315339)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 石崎敏理 (70293876)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. Hamada Fumihiko (70252707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 村上和成 (00239485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 二宮遼 (00794041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 久保修一 (60898097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 橋本悟 (60352150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 花田克浩 (90581009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 久保田敏昭 (30205140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 楠瀬直喜

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

AKAMINE TAKAHIRO 赤嶺 孝祐

Research Projects

Research Products

Co-Researchers

メタボローム解析から迫るROCK血管透過性調節機序解明とARDS治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Actin Regulator ROCK in Age-Related Exacerbation of Drug-Induced Renal Injury

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Wnt/β-catenin経路を標的とした眼内増殖性疾患の治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of pulmonary vascular permeability based on the ROCK signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of foundation for ARDS treatment based on controlling vascular permeabilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Gastric carcinogenesis caused by Helicoobacter pylori-induced inflammation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of skin homeostasis based on the regulation of actin cytoskeleton

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Inhibition of Wnt/beta-catenin to treat proliferative vitreoretinopathy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of blood-retinal barrier based on circadian expression of drug transporters.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (M?ller) cells2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] The ROCK signaling regulates the pulmonary vascular permeability via maintenance of lung homeostasis.2022

Author(s)

AKAMINE TAKAHIRO 赤嶺孝祐