Kawai Kentaro 河合健太郎

… Alternative Names

河合健太郎カワイケンタロウ

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Researcher Number	60826246
Other IDs
Affiliation (Current)	2025: 摂南大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 摂南大学, 薬学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 37030:Chemical biology-related Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 37030:Chemical biology-related
Keywords	Principal Investigator 薬物代謝酵素 / イミダゾリルフェノール誘導体 / 薬物動態学的増強因子（ブースター） / 低分子創薬 / アンテドラッグ / 薬物動態学的増強因子 Except Principal Investigator シメチジン / 阻害剤 / 多剤排出ポンプ / MATE1 … More / 歯周病菌 / アニリン誘導体 / 蛍光プローブ / プロリルトリペプチジルアミノペプチダーゼ / 酵素活性プローブ / アニリン / フッ素 / 小分子 / トリフルオロメチル基 / 蛍光性化合物 Less

アンテドラッグとして作用する、安全で新規な薬物動態学的増強因子の創出Principal Investigator
- Principal Investigator
  
  河合健太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Setsunan University
多剤耐性菌のMATE型多剤排出ポンプを選択的に阻害するリード化合物の創出
- Principal Investigator
  
  表雅章
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Setsunan University
Development of small molecule fluorescent compounds and elaboration of fluorescent probe for periodontal bacteria
- Principal Investigator
  
  Omote Masaaki
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Setsunan University

All 2024 2023 2022 2020 2019

All Journal Article Presentation

[Journal Article] Pentafluorosulfanyl-substituted biaryl derivatives as MATE-type transporter inhibitors targeting drug-resistant bacteria2024
- Author(s)
  Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 99 Pages: 117606-117606
- DOI
  10.1016/j.bmc.2024.117606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06514, KAKENHI-PROJECT-23K06125, KAKENHI-PROJECT-20K07059
[Journal Article] In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition2024
- Author(s)
  Kataoka Makoto、Takenaka Sae、Fujii Shota、Masada Takato、Minami Keiko、Takagi Toshihide、Omote Masaaki、Kawai Kentaro、Yamashita Shinji
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: - Pages: 101005-101005
- DOI
  10.1016/j.dmpk.2024.101005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K04969
[Journal Article] Fluorophenylalkyl-substituted cyanoguanidine derivatives as bacteria-selective MATE transporter inhibitors for the treatment of antibiotic-resistant infections2022
- Author(s)
  Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 74 Pages: 117042-117042
- DOI
  10.1016/j.bmc.2022.117042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07059, KAKENHI-PROJECT-22K06514
[Journal Article] Synthesis of Small Fluorescent Molecules and Evaluation of Photophysical Properties2020
- Author(s)
  Futa Ogawa, Yukiko Karuo, Ryuji Yamazawa, Kanae Miyanaga, Kazushige Hori, Keita Tani, Kengo Yamada, Yuki Saito, Kazumasa Funabiki, Atsushi Tarui, Kazuyuki Sato, Kiyoshi Ito, Kentaro Kawai, and Masaaki Omote*
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 85 Issue: 2 Pages: 1253-1258
- DOI
  10.1021/acs.joc.9b02857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05740, KAKENHI-PROJECT-17K05974
[Presentation] 細菌MATE型薬剤排出ポンプ阻害剤の探索合成と活性評価2023
- Author(s)
  新屋　進、河合健太郎、小林直木、軽尾友紀子、樽井　敦、佐藤和之、大塚正人、表　雅章
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] 細菌抗菌薬排出機構MATE型輸送体の新規阻害剤の探索合成と活性評価2023
- Author(s)
  新屋進, 河合健太郎, 小林直木, 軽尾友紀子, 樽井敦, 佐藤和之, 大塚正人, 表雅章
- Organizer
  第46回フッ素化学討論会
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] 薬物動態学的増強因子としての新規ベンジルオキシフェニルイミダゾール誘導体2023
- Author(s)
  河合健太郎、軽尾友紀子、樽井敦、佐藤和之、表雅章、山下伸二、片岡誠
- Organizer
  第51回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-23K04969
[Presentation] Development of a novel safe booster with antedrug characteristics to improve oral bioavailability of CYP3A Substrates2023
- Author(s)
  Makoto Kataoka, Shota Fujii , Takato Masada, Keiko Minami, Toshihide Takagi, Shinji Yamashita, Masaaki Omote, Kentaro Kawai
- Organizer
  2023 ICCP450/JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K04969
[Presentation] Exploration and Synthesis of Inhibitors Targeting the Bacterial Multidrug Efflux Pump MATE-type transporter2023
- Author(s)
  新屋進, 河合健太郎, 小林直木, 軽尾友紀子, 樽井敦, 佐藤和之, 大塚正人, 表雅章
- Organizer
  第40回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] Development of Selective Inhibitors Targeting Multi-antimicrobial extrusion transporter to Overcome Antibiotic Resistance2023
- Author(s)
  Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote
- Organizer
  23rd International Symposium on Fluorine Chemistry (ISFC) and the 9th International Symposium on Fluorous Technologies (ISoFT)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] CYP阻害活性を薬効とするアンテドラッグの開発：高阻害活性化合物の合成とその評価2023
- Author(s)
  藤井翔太、南景子、高木敏英、山下伸二、河合健太郎、表雅章、片岡誠
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-23K04969
[Presentation] 細菌多剤排出輸送体MATE阻害化合物の探索合成と活性評価2022
- Author(s)
  新屋　進、河合健太郎、小林直木、軽尾友紀子、樽井　敦、佐藤和之、大塚正人、表　雅章
- Organizer
  日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] 多剤耐性菌に有効な細菌選択的MATE 型輸送体阻害剤（SS-322）の創生2022
- Author(s)
  新屋　進, 河合健太郎, 小林直木, 軽尾友紀子, 樽井　敦, 佐藤和之, 大塚正人, 表　雅章
- Organizer
  創薬懇話会 2022 in名古屋
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] 多剤耐性菌に有効な細菌選択的MATE型輸送体阻害剤の創生2022
- Author(s)
  新屋　進, 河合健太郎, 小林直木, 軽尾友紀子, 樽井　敦, 佐藤和之, 大塚正人, 表　雅章
- Organizer
  第42回有機合成若手セミナー
- Data Source
  KAKENHI-PROJECT-22K06514
[Presentation] 歯周病菌産生酵素活性測定用プローブ合成と活性評価2022
- Author(s)
  軽尾友紀子、東野崇太、樽井敦、佐藤和之、山澤龍治、伊藤潔、河合健太郎、表雅章
- Organizer
  日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-19K05740
[Presentation] 歯周病菌の蛍光プローブ創製2022
- Author(s)
  軽尾友紀子、東野崇太、樽井敦、佐藤和之、河合健太郎、表雅章
- Organizer
  第45回フッ素化学討論会
- Data Source
  KAKENHI-PROJECT-19K05740
[Presentation] 2-Trifluoropropenylanilineを基本骨格とする低分子蛍光性有機化合物の合成と利用2019
- Author(s)
  小川風太、軽尾友紀子、谷敬太、樽井敦、佐藤和之、河合健太郎、表雅章
- Organizer
  第45回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-19K05740

1. Omote Masaaki (90299032)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
2. 軽尾友紀子 (30826235)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. 伊藤潔 (50201926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. 船曳一正 (50273123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 谷敬太 (60207165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 大塚正人 (30243489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. 片岡誠 (00340860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 小林直木

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawai Kentaro 河合 健太郎

河合 健太郎 カワイ ケンタロウ

Research Projects

Research Products

Co-Researchers

アンテドラッグとして作用する、安全で新規な薬物動態学的増強因子の創出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

多剤耐性菌のMATE型多剤排出ポンプを選択的に阻害するリード化合物の創出

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of small molecule fluorescent compounds and elaboration of fluorescent probe for periodontal bacteria

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Pentafluorosulfanyl-substituted biaryl derivatives as MATE-type transporter inhibitors targeting drug-resistant bacteria2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fluorophenylalkyl-substituted cyanoguanidine derivatives as bacteria-selective MATE transporter inhibitors for the treatment of antibiotic-resistant infections2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of Small Fluorescent Molecules and Evaluation of Photophysical Properties2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 細菌MATE型薬剤排出ポンプ阻害剤の探索合成と活性評価2023

Author(s)

Organizer

Data Source

[Presentation] 細菌抗菌薬排出機構MATE型輸送体の新規阻害剤の探索合成と活性評価2023

Author(s)

Organizer

Data Source

[Presentation] 薬物動態学的増強因子としての新規ベンジルオキシフェニルイミダゾール誘導体2023

Author(s)

Organizer

Data Source

[Presentation] Development of a novel safe booster with antedrug characteristics to improve oral bioavailability of CYP3A Substrates2023

Author(s)

Organizer

Data Source

[Presentation] Exploration and Synthesis of Inhibitors Targeting the Bacterial Multidrug Efflux Pump MATE-type transporter2023

Author(s)

Organizer

Data Source

[Presentation] Development of Selective Inhibitors Targeting Multi-antimicrobial extrusion transporter to Overcome Antibiotic Resistance2023

Author(s)

Organizer

Data Source

[Presentation] CYP阻害活性を薬効とするアンテドラッグの開発：高阻害活性化合物の合成とその評価2023

Author(s)

Organizer

Data Source

[Presentation] 細菌多剤排出輸送体MATE阻害化合物の探索合成と活性評価2022

Author(s)

Organizer

Data Source

[Presentation] 多剤耐性菌に有効な細菌選択的MATE 型輸送体阻害剤（SS-322）の創生2022

Author(s)

Organizer

Data Source

[Presentation] 多剤耐性菌に有効な細菌選択的MATE型輸送体阻害剤の創生2022

Kawai Kentaro 河合健太郎

河合健太郎カワイケンタロウ