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TAKASHIMA Sachio  高嶋 幸男

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… Alternative Names

高嶋 幸男  タカシマ サチオ

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Researcher Number 70038743
External Links
Affiliation (Current) 2025: 国際医療福祉大学, 医療福祉学研究科, 教授
Affiliation (based on the past Project Information) *help 2011: 国際医療福祉大学, 柳川療育センター, 教授
2002 – 2006: International University of Health & Welfare, Professor, 大学院, 教授
2003: 国際医療福祉大学院大学, 医療福祉学研究科, 教授
2002: 国際医療福祉大学, 大学院・医療福祉学研究科, 教授
2001: 国立精神・神経センター, 神経研究所, 所長 … More
2001: 国立精神神経センター, 神経研究所, 部長
2000 – 2001: 国立精神神経センター, 神経研究所, 所長
1997 – 2001: 国立精神・神経センター, 神経研究所, 部長
2000: National Research Center for Neuroscience, Director, 所長
2000: National Institute of Neuroscience, NCNP, Director General, 神経研究所, 所長(研究職)
1999: 国立精神・神経センター, 武蔵病院・臨床検査部, 部長(研究職)
1999: 国立精神・神経センター, 神経研究所・検査部長室, 部長
1999: 精神神経セ
1998: 国立精神, 神経センター神経研究所, 部長(研究職)
1998: 国立精神, 神経センター神経研究所・疾病研究第2部, 部長
1998: 国立精神・神経センター, 疾病研究第2部, 部長
1997: National Institute of Neuroscience, National Center of Neurology and Psychiatry, Director of Department, 神経研究所2部, 部長
1997: National Institute of Neuroscience, National Center of Neurology and Psychiatory, Director of Department, 神経研究所・2部, 部長
1997: 国立精神・神経センター, 神経研究所・疾病研究第2部, 部長
1996 – 1997: 国立精神, 神経センター神経研究所, 部長
1996: 国立精神神経センター, 神経研究所・疾病第2部, 部長
1995: 国立精神・神経センター, 神経研究所・2部, 部長
1995: 国立精神神経センター神経研究所2部, 部長
1994: Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry., 神経研究所・疾病研究第2部, 部長
1993: 国立精神, 神経センター・神経研究所, 部長
1993: 国立精神・神経センター, 神経研究所・疾病研究第二部, 部長
1992: 国立精神・神経センター, 神経研究所疾病研究第2部, 部長
1990 – 1991: 国立精神・神経センター, 神経研究所・疾病研究第2部, 部長
1987: Head, Division of Mental Retardation and Birth Defect Research, National Center, 神経センター, 部長
1986: 鳥取大, 医学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Pediatrics / Embryonic/Neonatal medicine / Rehabilitation science/Welfare engineering
Except Principal Investigator
Pediatrics / Pediatrics / Human genetics / Embryonic/Neonatal medicine / 情報システム学(含情報図書館学)
Keywords
Principal Investigator
乳幼児突然死症候群 / MRI / brain damage / 免疫組織化学 / 脳室周囲白質軟化 / 神経細胞壊死 / 脳障害 / 新生児 / 中枢神経 / 神経伝達物質 … More / カテコラミン / 脳バンク / developmental disorder / neonate / care system / perinatal brain damage / cranial imaging / computer system / 発達障害 / 療育システム / 周産期脳障害 / 頭部画像 / コンピューターシステム / serotonin receptor / chatecholamine / neurotransmitter / respiratory regulation / brainstem / sudden infant death syndrome / セロトニン受容体 / 呼吸調節 / 脳幹 / monitoring / cerebral circulation / nitrogen oxide / 低酸素症 / 脳血流 / モニター / 脳循環調節 / 一酸化窒素 / brain banking / glia / brain malformation / leukomalacia / neuron death / immunohistochemistry / central nervous sytem / 神経細胞死 / 結節性硬化症 / 脳発達 / 脳組織バンク / 脳血管 / グリア / 脳形成異常 / 神経細胞懐死 / Peroxisome / SIDS / Leukomalacia / Hydrocephalus / Ferritin / Neuronal necrosis / Neonate / 呼吸中枢 / 髄鞘形成 / 白質軟化 / 周産期 / 神経堤 / 興奮性アミノ酸 / 乳児突然死症候群 / ペルオキシソーム / 水頭症 / フェリチン / down syndrome / brain anomaly / catecholamine / peroxisome / neuron / mental retardation / synapsis / 脳奇形 / ダウン症候群 / ペロキシゾ-ム / ニュ-ロン / 精神遅滞 / シナプシス / ドーパミン受容体 / グルタミン酸受容体 / 小児遺伝性神経疾患 / 新生児脳障害 … More
Except Principal Investigator
SIDS / neonate / methyl-CpG-binding protein2 / 遺伝子発現 / fukutin / hamartin / DCAMKL1 / doublecortin / ^<13>C breath test / calcium / stable isotope / trace element / Tuberous sclerosis / PAF / tuberin / アポトーシス / 結節性硬化症 / Bak / Dementia / Developmental delay / Synapsis / Dendrite / Neuron / 脳低酸素症 / ニユーロン / 脳発達 / 痴呆 / Dovn症候群 / 発達遅滞 / シナプシス / 樹状突起 / 神経細胞 / Neuroimaging / Memory / Cognitive function / Polymorphism / Laterality / Brain / グルタミン酸受容体 / 脳機能画像 / 記憶 / 脳機能 / 遺伝子多型 / 左右差 / 脳 / regenerative medicine / gene therapy / model mouse / neuromodulator / neurotransmitter / Rett Syndrome / 神経修飾因子 / 神経伝達物質 / Methyl-CpG-binding protein2 / 再生医学 / 遺伝子治療 / X^-) / ヘテロ(X / Y) / ヘミ(X^- / モデル動物 / methyl-CpG-binding Protein2 / Rett症候群 / apoptosis / brainstem / TUNEL / 新生児SIDS / 脳幹 / 新生児 / Sox family / Human fetal brain / Gene expression / fetal brain-specific expression / Differential display / Differential Display / ヒト胎児大脳 / Soxファミリー / ヒト胎児脳 / Fukuyama type congenital muscular dystrophy / Subcortical laminar heterotopia / Lissencephaly / 全前脳症 / telencephalin / Zellweger症候群 / Ekerラット / LIS1 / 福山型先天性筋ジストロフィー / 皮質下層状ヘテロトピア / 滑脳症 / neutron capture analysis / trace mineral / meonate / helycobacter pylor / trace elements / neutrone capture analysis / PAF acetylhydrolase / Tuberin / Apoptosis / Miller-Dieker syndrome / PAFアセチルハイドロラーゼ / Miller-Dieker症候群 / カフェイン / CPT II / SNP / ADORA2a / 痙攣重積 / ナトリウムチャネル / アデノシン受容体 / カルニチンパルミトイルトランスフェラーゼII / 小児神経学 / ミトコンドリア / イオンチャネル / サイトカイン / アデノシン / 痙攣重積型急性脳症 / 急性壊死性脳症 / 一塩基多型 / 遺伝子解析 / 急性脳症 / 高次脳機能障害 / 脳性麻痺 / 虚血性脳傷害 / 神経前駆細胞 / 超早産児 / 脳室周囲白質軟化症 / MERIT-9 / HL7 / DICOM / XML / 可搬性 / 病歴 / 情報開示 / 医療情報 / 微細構造 / 低酸素 / 培養神経細胞 Less
  • Research Projects

    (19 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (46 People)
  •  Etiology, pathology and pathogenesis of acute necrotizing encephalopathy and acute encephalopathy with biphasic seizures and late reduced diffusion

    • Principal Investigator
      MIZUGUCHI Masashi
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The University of Tokyo
  •  超未熟児に伴う脳障害の病態研究-神経幹細胞障害モデルと幹細胞移植治療への展望

    • Principal Investigator
      井上 健
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Establishment of follow-up care system of patients with developmental disabilities with electronic record card and prevention of brain damagePrincipal Investigator

    • Principal Investigator
      TAKASHIMA Sachio
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Rehabilitation science/Welfare engineering
    • Research Institution
      International University of Health and Welfare Graduate School
  •  Developmental mechanisms of higher cognitive functions: comprehensive analyses of genes involved in hemispheric laterality

    • Principal Investigator
      KIRA Ryutaro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      KYUSHU UNIVERCITY
  •  Molecular Besis of MeCP2 null-mutation Model Mouse and Gene Therapy

    • Principal Investigator
      MATSUISHI Toyojiro
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kurume University
  •  長期保存と再利用を目指した医療データの患者自身による携帯性に関する研究

    • Principal Investigator
      SIBAHARA Tetsutaro
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      情報システム学(含情報図書館学)
    • Research Institution
      Fukushima University
  •  Characteristics of apoptosis in the brainstem of neonatal SIDS victims

    • Principal Investigator
      SAWAGUCHI Toshiko
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Women's Medical University
  •  Identification and analysis of genes specially expressed in fetal and newborn brains

    • Principal Investigator
      YASUKOCHI Yukio
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human genetics
    • Research Institution
      Tokyo Medical and Dental University, Medical Research Institute
  •  Neuronal migration : its mechanism in normal development and pathologic changes in cerebral dysgenesis.

    • Principal Investigator
      MIZUGUCHI Masashi
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jichi Medical School
  •  胎児・新生児脳組織バンキングによる脳障害の分子発生病理学的研究Principal Investigator

    • Principal Investigator
      高嶋 幸男
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Genetic and molecular pathological studies on pathogens is of sudden infant death syndromePrincipal Investigator

    • Principal Investigator
      TAKASHI Sachio
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Pediatrics
    • Research Institution
      National Center of Neurology and Psychiatry
  •  Trace elements and their effect on ontogenic development of human

    • Principal Investigator
      HIROSHI Nishida
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      Tokyo Women's Medical University
  •  Molecular pathology of neuronal differentiation, migration and death in developmental disorders.

    • Principal Investigator
      MIZUGUCHI Masashi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jichi Medical School
  •  Molecular pathology on pathogenesis of brain damage using by developmental brain tissue bankingPrincipal Investigator

    • Principal Investigator
      TAKASHIMA Sachio
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      National Institute of Neuroscience, National Center of Neurology nad Psychiatry
  •  Exploitation of continuous monitoring apparatus of nitric oxide in vivoPrincipal Investigator

    • Principal Investigator
      TAKASHIMA Sachio
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pediatrics
    • Research Institution
      National Institute of Neuroscience, National Center of Neurology nad Psychiatry
  •  環境因子が培養神経細胞に及ぼす微細構造変化についての研究

    • Principal Investigator
      MITO Takashi
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      National Center of Neurology and Psychiatry
  •  A study on pathogenesis of perinatal brain damage by brain tissue banking systemPrincipal Investigator

    • Principal Investigator
      TAKASHIMA Sachio
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      National Institute of Neuroscience, National Center of Neurology and Psychiatry
  •  A study on synaptic transmission system in mental retardation.Principal Investigator

    • Principal Investigator
      TAKASHIMA Sachio
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      National Institute of Neuroscience, National center of Neurology and Psychiatry
  •  Experimental study on developmental delay and promotion of the brain.Principal Investigator

    • Principal Investigator
      ANDO Yukinori, 高嶋 幸男
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Division of Child Neurology, Tottori University School of Medicine

All 2006 2005 2004 2003 Other

All Journal Article Book

  • [Book] 乳幼児突然死症候群(有田秀穂編 : 呼吸の事典)2005

    • Author(s)
      小沢愉理, 高嶋幸男
    • Publisher
      朝倉書店
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Neuropathology of methylmalonic acidemia in a child2006

    • Author(s)
      高嶋 幸男
    • Journal Title

      Pediatr Neurol 34

      Pages: 156-159

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Early and late development of Notch 3 in human brains.2005

    • Author(s)
      高嶋 幸男
    • Journal Title

      Neuroembryology 3

      Pages: 13-18

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] 電子記録カードを用いた療育システムと障害予防2005

    • Author(s)
      高嶋 幸男
    • Journal Title

      日本重症心身学会誌 30(2)

      Pages: 173-173

    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Pathogenesis and prevention of pontosubicular necrosis.2005

    • Author(s)
      Takashima S, Ichinohe A, Itoh M
    • Journal Title

      Neuroembryology 3

      Pages: 42-46

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Approach from neuropathology on pathogenesis of SIDS.2005

    • Author(s)
      Ozawa Y, Takashima S, Tada H
    • Journal Title

      Japan SIDS Research Journal (Japanese) 5

      Pages: 38-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] SIDS2005

    • Author(s)
      Ozawa Y, Takashima S
    • Journal Title

      Dictionary of respiration(Arita H edn)(Asakura Pub., Tokyo)

      Pages: 313-324

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Expression of glutamate transporter subtypes during normal corticogenesis and type lissencephaly.2005

    • Author(s)
      Furuta A, Takashima S, Yokoo H, Rothstein JD, Wada K, Iwaki T
    • Journal Title

      Develop Brain Res 155

      Pages: 155-164

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Cystathionine β-synthase is enriched in the brains of Down7S patients.2005

    • Author(s)
      Ichinohe A, Kanaumi T, Takashima S, Enokido Y, Nagai Y, Kimura H
    • Journal Title

      Biochemical and Biophysical Research Communications 338

      Pages: 1547-1550

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Cystachionine β-synthse is enriched in the brains of Down' s patients2005

    • Author(s)
      高嶋 幸男
    • Journal Title

      Biochem Biophys Res Commun 338

      Pages: 1547-1550

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Pathogeneisis and prevention of pontosubicular necrosis.2005

    • Author(s)
      高嶋 幸男
    • Journal Title

      Neuroembryology 3

      Pages: 42-46

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Early and late development of Notch 3 in human brains.2005

    • Author(s)
      Ichinohe A, Takahashi K, Tabira T, Takashima S
    • Journal Title

      Neuroembryology 3

      Pages: 13-18

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Cystachionine β-synthse is enriched in the brains of Down's patients2005

    • Author(s)
      高嶋 幸男
    • Journal Title

      Biochem Biophys Res Commun(BBRC) 338

      Pages: 1547-1550

    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] SIDSの病因における脳病理からアプローチ2005

    • Author(s)
      高嶋 幸男
    • Journal Title

      日本SIDS学会誌 5

      Pages: 38-44

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Pathogenesis, plasticity and prevention of perinatal hypoxic- ischemic brain damage.2004

    • Author(s)
      Takashima S
    • Journal Title

      Abstract of 8th Asian and Oceanian Congress of Child Neurology, New Delhi, Oct 8

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] FLAIR (fluid attenuated inversion recovery)法MRI画像による新生児脳の髄鞘化と脳室周囲白質軟化症の観察2004

    • Author(s)
      高嶋 幸男
    • Journal Title

      日本周産期・新生児学会雑誌 40

      Pages: 70-75

    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] α 2-adrenergic ceptor subtype alterations in the brainstem in the sudden infant death syndrome.2004

    • Author(s)
      高嶋 幸男
    • Journal Title

      Pathophysiology 10

      Pages: 229-234

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] α2-adrenergic ceptor subtype alterations in the brainstem in the sudden infant death syndrome.2004

    • Author(s)
      高嶋 幸男
    • Journal Title

      Pathophysiology 10

      Pages: 229-234

    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Pathogenesis, plasticity and prevention of perinatal hypoxic-ischemic brain damage2004

    • Author(s)
      高嶋 幸男
    • Journal Title

      Indian J Pediatrics : Asean-Oseanian Congress of Child Neurology SS-1

      Pages: 1-1

    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] α2-adrenergic ceptor subtype alterations in the brainstem in the sudden infant death syndrome.2004

    • Author(s)
      Ozawa Y, Takashima S, Tada H
    • Journal Title

      Pathophysiology 10

      Pages: 229-234

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Developmental neurotransmitters pathology in SIDS.2004

    • Author(s)
      Takashima S
    • Journal Title

      Abstract of SIDS International Conference in Canada, Edmonton, July 3

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Absence of allelic loss in cytomegalic neurons of cortical tuber in the Ecker rat model of tuberous sclerosis.2004

    • Author(s)
      高嶋 幸男
    • Journal Title

      Acta Neuropathol 107

      Pages: 47-52

    • Data Source
      KAKENHI-PROJECT-16300185
  • [Journal Article] Myelin transcription factor 1 (MyT1) immuneoreactivity in infants with perivetricular Leukomalacia2003

    • Author(s)
      Hirayama A, Takashima S
    • Journal Title

      Developmental Brain Reseach 140

      Pages: 85-85

    • Data Source
      KAKENHI-PROJECT-14370255
  • [Journal Article] Myelin transcription factor 1 (MyT1) immuneoreactivity in infants with perivetricular Leukomalacia2003

    • Author(s)
      Hirayama A, Takashima S et al.
    • Journal Title

      Developmental Brain Reseach 140

      Pages: 85-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370255
  • [Journal Article] Myelin transcription factor 1 (MyT1) immuneoreactivity in infants with perivetricular Leukomalacia2003

    • Author(s)
      Hirayama A,...Takashima S
    • Journal Title

      Developmental Brain Reseach 140

      Pages: 85-85

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370255
  • [Journal Article] Brains of extremely premature infants with white matter injury also exhibit altered neural progenitor cells and cortical development.

    • Author(s)
      Deguchi K, Takashima S, Armstrong DL, Inoue K
    • Journal Title

      (In preparation)

    • Data Source
      KAKENHI-PROJECT-17659324
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