MASUDA Junichi 益田順一

Researcher Number	70173747
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2008 – 2010: Shimane University, 医学部, 教授 2003 – 2006: Shimane University, Professor, 医学部, 教授 1996 – 2002: Shimane Medical University, Professor, 医学部, 教授 1994 – 1995: 国立循環器病センター研究所, 室長 1994: 国立循環器病センター, 室長 … More 1993 – 1994: 国立循環器病センター研究所, 疫学部, 室長 1991: NCVC Research Institute, 疫学部, 室長 1990: 国立循環器病センター研究所, 循環動態機能部機能評価研究室, 室員 Less
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / 臨床疫学 / Laboratory medicine Except Principal Investigator 医薬分子機能学 / Circulatory organs internal medicine / Neurology / Neurology / Thoracic surgery / Applied health science
Keywords	Principal Investigator 動脈硬化 / マクロファージ / ラクナ梗塞 / methylated arginines / NO synthase / isoprostane / oxidative stress / lacunes / PVH / arteriosclerosis … More / cerebrovascular diseases / 一酸化窒素 / 多検体測定 / HPLC / ADMA / メチル化アルギニン / 一酸化窒素合成酵素 / イソプロステイン / 酸化ストレス / 白質変性 / 脳動脈硬化 / 脳血管障害 / hypertension / cytokine / biglycan / decorin / extracellular matrix / smoothh muscle cell / macrophage / stent / 血管形成術 / 組織適合性抗原 / 血管壊死 / 高血圧 / サイトカイン / バイグリカン / デコリン / 細胞外マトリックス / 平滑筋 / ステント / adhesion molecules / apoptosis / antigen-presenting cells / atherogenesis / macrophages / プロテインキナーゼC / チロシンリン酸化 / 細胞内情報伝達 / 単球遊走因子 / 単球 / 接着分子 / アポトーシス / 抗原提示細胞 / 冠動脈疾患 / トロンボモジュリン / トロンビン受容体 / 無症侯性脳梗塞 / Lp(a) / 遺伝子多型 / LDLコレステロール / リポ蛋白 / 遺伝子変異 / PAF-AH / 脳梗塞 … More Except Principal Investigator サイトカイン / triglyceride / cerebral stroke / cholesterol / quantitative trait locus / genetics / stroke-prone spontaneously hypertensive rats / 脳梗塞 / MRI / 活性酸素 / 炎症 / 細胞接着 / 白血球 / 血小板 / 平滑筋細胞 / PDGF / apoptosis / stroke medel rat / neurotrophic factors / stem cells / cell transplantation / regenerative medicine / cerebral infarction / 栄養因子 / ミクログリア / 骨髄間葉系幹細胞 / 神経幹細胞 / 脳梗塞モデルラット / リアルタイムPCR / 神経保護 / 移植 / アポトーシス / モデルラット / 神経栄養因子 / 幹細胞 / 細胞移植 / 再生医療 / Hemodialysis / Sulfated carbohydrate / Sialic acid / Reactive oxygen species / Leukocyte / Platelet / Cell adhesion / P-selectin / 細胞表面糖鎖 / 腫瘍壊死因子 / 炎症反応 / 生体適合性 / 抗接着療法 / 血液透析 / 硫酸化糖鎖 / シアル酸 / P-セレクチン / 脳卒中 / コレステロール / QTL / 量的形質 / 連鎖解析 / 脳卒中易発症自然発症高血圧ラット / Dementia / BLOOD PRESSURE / STROKE RECURRENCE / STROKE PATIENT / SILENT BRAIN INFARCTION / 無症侯性脳梗塞 / Stroop検査 / CP(a)Phenotype / 脳ドッグ / 脳血流 / 無症候性脳梗塞 / Wisconsin card sorting test / Lp(a)phenotype / 脳ドック / 脳卒中再発 / Lp(a)フェノタイプ / 高血圧 / 脳卒中家族歴 / 痴呆 / 血圧 / 脳血管障害再発 / 脳血管障害患者 / 無症候性脳血管障害 / CARBOHYDRATE CHAIN / SELECTIN / CYTOKINE / OXYGEN RADICAL / INFLAMMATION / CELL ADHESION / LEUKOCYTE / PLATELET / スーパーオキシド / TNF / 糖鎖 / セレクチン / Stent / Vein graft / Vein graft disease / HVJ liposome method / Gene transfection / 再狭窄 / 遺伝子治療 / 静脈グラフト病変 / アンチセンス / ステント / 静脈グラフト / Vein Graft Disease / HVJリボゾーム法 / 遺伝子導入 / Autocrine / Proliferation / Smooth Muscle Cells / Interferon Gamma / Cytokines / Atherosclerosis / 増殖抑制 / 平滑筋 / マクロファ-ジ / リンパ球 / PDGFレセプタ- / インタ-フェロン / 動脈硬化 / 頸動脈エコー / 肥満 / 疫学 / 危険因子 / 認知機能 / 生活満足度 / 食事習慣 / 遺伝子多型解析 / メタボリック症候群 / 健康調査 / 生活習慣病 / 横断研究 / ソーシャルキャピタル / コホート / 遺伝子多型 / 保健健康管理 Less

Long-term follow-up population study of rural residents for prediction and prophylaxis of life-style related diseasesPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Syuhei, 益田順一
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Shimane University
Regenerative medicine for cerebral infarction: Stem cell transplantation in the rat model of middle cerebral artery occlusion
- Principal Investigator
  
  NAGAI Atsushi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Shimane University
Genetic predisposition of cerebrovascular diseases and their prophylactic strategyPrincipal Investigator
- Principal Investigator
  
  MASUDA Junichi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  臨床疫学
- Research Institution
  Shimane University
Regulation of platelet-leukocyte interaction and pharmaceutical application
- Principal Investigator
  
  TSUJI Tsutomu
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Hoshi University
Identification of QTLs for various lipid phenotypes In the stroke-prone spontaneously hypertensive rats and their relation to the susceptibility to cerebral stroke
- Principal Investigator
  
  NABIKA Toru
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Shimane Medical University
遺伝子多型マーカーによる血管合併症の一次予防とその診断方の開発Principal Investigator
- Principal Investigator
  
  益田順一
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Shimane Medical University
LONGITUDINAL STUDY ON STROKE RECURRENCE AND DEVELOPMENT OF DEMENTIA
- Principal Investigator
  
  KOBAYASHI Shotai
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  SHIMANE MEDICAL UNIVERSITY
Role of macrophages and extracellular matrix in vascular remodelingPrincipal Investigator
- Principal Investigator
  
  MASUDA Junichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Shimane Medical University
The Research for Regulation of Vascular Stenosis by Antisense Delivery System
- Principal Investigator
  
  SAWA Yoshiki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka University
Development of anti-inflammatory drugs affecting functions of platelet adhesion molecules
- Principal Investigator
  
  TSUJI Tsutomu
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  University of Tokyo
Role of Hematopoietic Factors in Regulation of Macrophage Functions During AtherogenesisPrincipal Investigator
- Principal Investigator
  
  MASUDA Junichi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  NATIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE
The Effect of IFN-gamma on Proliferation of Vascular SMCS.
- Principal Investigator
  
  SHIMOKADO Kentaro
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute

All 2011 2010 2009 2008 2005 2004

All Journal Article Presentation

[Journal Article] Effects of Six Functional SNPs on the Urinary 8-isoprostane Level in a General Japanese Population;2011
- Author(s)
  Suyama Y, Matsuda C, Isomura M, Hamano T, Karino K, Yamasaki M, Yamaguchi S, Shiwaku K, Masuda J, Nabika T
- Journal Title
  
  Shimane COHRE Study.Disease Markers 30in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300220
[Journal Article] Microglia transplantation attenuates white matter injury in rat chronic ischemia model via matrix metalloproteinase-2 inhibition.2010
- Author(s)
  Narantuya D, Nagai A, Sheikh AM, Wakabayashi K, Shiota Y, Watanabe T, Masuda J, Kobayashi S, Kim SU, Yamaguchi S
- Journal Title
  
  Brain Res 1316
  
  Pages: 145-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300220
[Journal Article] Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model.2010
- Author(s)
  Wakabayashi K, Nagai A, Sheikh AM, Shiota Y, Narantuya D, Watanabe T, Masuda J, Kobayashi S, Kim SU, Yamaguchi S
- Journal Title
  
  J Neurosci Res 88
  
  Pages: 1017-1025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300220
[Journal Article] Human microglia transplanted in rat focal ischemia brain induce neuroprotection and behavioral improvement.2010
- Author(s)
  Narantuya D, Nagai A, Sheikh AM, Masuda J, Kobayashi S, Yamaguchi S, Kim SU
- Journal Title
  
  PloS one 5:e11746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300220
[Journal Article] Evaluation of asymmetric dimethylarginine and homocysteine in microangiopathy-relatede cerebral damage.2009
- Author(s)
  Notsu Y, Nabika T, Bokura H, Suyama Y, Kobayashi S, Yamaguchi S, Masuda J
- Journal Title
  
  Am J Hypertens 22
  
  Pages: 257-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300220
[Journal Article] Effects of G994T in the Lp-PLA2 gene on the plasma oxidized LDL level and carotid intima-media thickness in Japanese : the Shimane study.2009
- Author(s)
  Wang T, Karino K, Yamasaki M, Zhang Y, Masuda J, Yamaguchi S, Shiwaku K, Nabika T
- Journal Title
  
  Am J Hypertens. 22
  
  Pages: 742-747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300220
[Journal Article] Evaluation of diabetic neuropathy using the tone-entropy analysis, a noninvasive method to estimate the autonomic nervous function.2009
- Author(s)
  Karino K, Nabika T, Nishiki M, Iijima K, Nagai A, Masuda J
- Journal Title
  
  Biomed Res 30
  
  Pages: 1-6
- NAID
  130004903743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300220
[Journal Article] Lysophosphatidylcholine induces glial cell activation : role of rho kinase.2009
- Author(s)
  Sheikh AM, Nagai A, Ryu JK, McLarnon JG, Kim SU, Masuda J
- Journal Title
  
  Glia 57
  
  Pages: 898-907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300220
[Journal Article] Cystatin C expression in ischemic white matter lesions.2008
- Author(s)
  Umegae N, Nagai A, Terashima M, Watanabe T, Shimode K, Kobayashi S, Masuda J, Kim SU, Yamaguchi S
- Journal Title
  
  Acta Neurol Scand 118
  
  Pages: 60-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300220
[Journal Article] Involvement of cystatin C in pathophysiology of CNS diseases.2008
- Author(s)
  Nagai A, Terashima M, Sheikh AM, Notsu Y, Shimode K, Yamaguchi S, Kobayashi S, Kim SU, Masuda J
- Journal Title
  
  Front Biosci 13
  
  Pages: 3470-3479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20300220
[Journal Article] 脳血管障害の危険因子2005
- Author(s)
  益田順一
- Journal Title
  
  臨床病理 53
  
  Pages: 422-429
- NAID
  10016685136
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16615004
[Journal Article] 頚動脈硬化の病理2004
- Author(s)
  益田順一
- Journal Title
  
  脳卒中 26
  
  Pages: 614-616
- NAID
  10017000495
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16615004
[Journal Article] Moyamoya Disease2004
- Author(s)
  Masuda J, et al.
- Journal Title
  
  Stroke (Mohr JP, Choi DW, Grotta JC, Weir B, Wolf PA (eds)) Pathophysiology, Diagnosis, and Management(4th ed.Philadelphia : Churchill Livingstone)
  
  Pages: 603-618
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16615004
[Presentation] Modulation of transcription factors expression by mesenchymal stem cell transplantation in rat MCAO model.2010
- Author(s)
  Sheikh AM, Nagai A, Narantuya D, Masuda J, Kobayashi S, Yamaguchi S
- Organizer
  第22回日本脳循環代謝学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-20300220
[Presentation] 脳虚血ラットのIBa1/ED1陽性細胞における遺伝子発現の相違2010
- Author(s)
  Narantuya D, 長井篤, Sheikh AM, 益田順一, 小林祥泰, 山口修平
- Organizer
  Stroke2010(第35回日本脳卒中学会,第39回日本脳卒中の外科学会,第26回スパズム・シンポジウム)
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-20300220
[Presentation] 脳卒中モデル動物の骨髄間葉系幹細胞移植による症状改善因子の検討2009
- Author(s)
  長井篤, 若林規良, Sheikh AM, 渡邊達三, 塩田由利, 三瀧真悟, Narantuya D, 益田順一, 小林祥泰, 山口修平
- Organizer
  Stroke2009(第34回日本脳卒中学会,第38回日本脳卒中の外科学会,第25回スパズム・シンポジウム)
- Place of Presentation
  松江
- Data Source
  KAKENHI-PROJECT-20300220
[Presentation] 間葉系幹細胞移植による脳梗塞モデルラットの神経炎症の抑制効果2009
- Author(s)
  Sheikh AM, 長井篤, 若林規良, 塩田由利, Narantuya D, 小林祥泰, 山口修平, 益田順一
- Organizer
  第50回日本神経病理学会総会学術研究会
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-20300220
[Presentation] The Plasma Level of ARG/ADMA was Assoicated with the Microangiopathy-related Cerebral Damage (MARCD).2009
- Author(s)
  Nabika T, Notsu Y, Bokura H, Suyama Y, Kobayashi S, Yamaguchi S, Masuda J
- Organizer
  19^<th> European Meeting on Hypertension
- Place of Presentation
  Milan
- Data Source
  KAKENHI-PROJECT-20300220
[Presentation] Mesenchymal stem cell transplantation inhibits iNOS and COX-2 in MCAO rats.2008
- Author(s)
  Sheikh AM, 長井篤, 若林規良, 塩田由利, 山口修平, 益田順一
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20300220
[Presentation] Cystain C刺激培養神経細胞におけるアポトーシス関連因子の発現2008
- Author(s)
  塩田由利, 長井篤, Sheikh AM, 益田順一, Kim SU, 山口修平
- Organizer
  第49回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20300220
[Presentation] 脳虚血モデルにおけるrhoキナーゼ阻害剤のミクログリア/マクロファージ抑制効果2008
- Author(s)
  長井篤, Chowdhury MH, Sheikh AM, 渡邊達三, 小林祥泰, 益田順一, 山口修平
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20300220
[Presentation] Alcohol and Aldehyde Dehydrogenase Polymorphisms and 20-year Follow-up Blood Pressure in Japanese.2008
- Author(s)
  Wang T, Shiwaku K, Yamasaki M, Masuda J, Yamaguchi S, Nabika T
- Organizer
  13^<th> International SHR Symposium
- Place of Presentation
  Prague
- Data Source
  KAKENHI-PROJECT-20300220
[Presentation] 慢性脳虚血ラット脳におけるサイトカイン、栄養因子、プロテアーゼの発現検討2008
- Author(s)
  Narantuya D, 長井篤, Sheikh AM, 益田順一, 小林祥泰, Kim SU, 山口修平
- Organizer
  第49回日本神経病理学会総会学術研究会
- Place of Presentation
  東京
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-20300220

1. KOBAYASHI Shotai (00118811)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. NABIKA Toru (50180534)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
3. YAMAGUCHI Syuhei (80135904)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
4. TSUJI Tsutomu (00143503)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. SHIWAKU Kuninori (10108384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. SHIMOKADO Kentaro (30192115)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAWA Yoshiki (00243220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKAHASHI Toshiki (50263257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FUKUSSHIMA Norihide (30263247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIRAKURA Ryota (00116047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YAMAMOTO Kazuo (20174782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. IMAI Yasuyuki (80160034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IRIMURA Tatsuro (80092146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ABUMIYA Takeo (80270726)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. OGAWA Hiroshi (00133546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAGAI Atsushi (40273940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TERASHIMA Masaharu (40227517)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HAYSHI Kazuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MASUDA Junichi 益田 順一

Research Projects

Research Products

Co-Researchers

Long-term follow-up population study of rural residents for prediction and prophylaxis of life-style related diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regenerative medicine for cerebral infarction: Stem cell transplantation in the rat model of middle cerebral artery occlusion

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic predisposition of cerebrovascular diseases and their prophylactic strategyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of platelet-leukocyte interaction and pharmaceutical application

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of QTLs for various lipid phenotypes In the stroke-prone spontaneously hypertensive rats and their relation to the susceptibility to cerebral stroke

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

遺伝子多型マーカーによる血管合併症の一次予防とその診断方の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

LONGITUDINAL STUDY ON STROKE RECURRENCE AND DEVELOPMENT OF DEMENTIA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of macrophages and extracellular matrix in vascular remodelingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Research for Regulation of Vascular Stenosis by Antisense Delivery System

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of anti-inflammatory drugs affecting functions of platelet adhesion molecules

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Hematopoietic Factors in Regulation of Macrophage Functions During AtherogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Effect of IFN-gamma on Proliferation of Vascular SMCS.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effects of Six Functional SNPs on the Urinary 8-isoprostane Level in a General Japanese Population;2011

Author(s)

Journal Title

Data Source

MASUDA Junichi 益田順一