Miyata Yoshihiko 宮田愛彦

… Alternative Names

MIYATA Yoshihiko 宮田愛彦

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Researcher Number	70209914
Other IDs
External Links
Affiliation (Current)	2025: 京都大学, 生命科学研究科, 助教
Affiliation (based on the past Project Information) *help	2018 – 2023: 京都大学, 生命科学研究科, 助教 2012 – 2015: 京都大学, 生命科学研究科, 助教 2010: 京都大学, 生命科学研究科, 助教 2008 – 2010: Kyoto University, 大学院・生命科学研究科, 助教 2006: 京都大学, 大学院生命科学研究科, 助手 … More 2005 – 2006: 京都大学, 生命科学研究科, 助手 2005: 京都大学, 生命科学研究所, 助手 2004: 京都大学, 大学院・生命科学研究科, 助手 1999 – 2003: 京都大学, 生命科学研究科, 助手 1996: 財団法人東京都臨床医学総合研究所, 細胞生物学研究部門, 研究員 1996: 財団法人東京都臨床医学総合研究所, 細胞生物学, 研究員 1995: (財)東京都臨床医学総合研究所, 細胞生物学研究部門, 研究員 1994 – 1995: 財団法人東京都臨床医学総合研究所, 細胞生物学研究部門, 研究員 1993: TMIMS.Dept. Cell. Biol., Res. Sci. 1993: TMIMS.Dept. Cell. Biol., Res. Sci., 細胞生物学研究部門, 研究員 1993: 財団法人東京都臨床医学総合研究所, 細胞生物学研究部門, 研究員 1993: 都臨床研, 細胞生物, 研究員 1992: 財団法人東京都臨床医学総合研究所 1992: 財団法人東京都臨床医学総合研究所, 細胞生物, 研究員 1991: 東京都臨床医学総合研究所, 細胞生物, 研究員 1990: (財)東京都臨床医学総合研究所, 細胞生物学研究部門, 研究員 1989: 都臨床研, 細胞生物, 研究員 Less
Review Section/Research Field	Principal Investigator Cell biology / Functional biochemistry / Biological Sciences / Basic Section 43030:Functional biochemistry-related / Biological Sciences Except Principal Investigator Structural biochemistry / 物質生物化学
Keywords	Principal Investigator 分子シャペロン / Cdc37 / キナーゼ / シグナル伝達 / Hsp90 / HSP90 / DYRK / MOK / Kinase / CK2 … More / MAPK / リン酸化 / ダウン症候群 / WDR68 / DYRK1A / Dyrk / ゲルダナマイシン / HSP / ストレス蛋白質 / HIPK / Proteasome / Molecular chaperone / プロテアソーム / タンパク質間相互作用 / タンパク質キナーゼ / WD40ドメイン / タンパク質リン酸化 / 細胞増殖 / GRP94 / 核移行シグナル / カゼインキナーゼII / 熱ショック蛋白質 / 自閉症スペクトラム症候群 / リン酸化プロテオーム解析 / DCAF7/WDR68 / FAM53C / WDR68/DCAF7 / Down's syndrome / geldanamycin / Protein kinases / Dyrk2 / Knockout Mouse / Molecular Chaperone / ES細胞 / ゲノム構造 / ノックアウトマウス / Signal transduction / 細胞周期 / 発がんプロモーター / ESTクローニング / MAPキナーゼ / TCP1α / TRiC/CCT / タンパク質フォルディング / プロテインキナーゼ / 天然変性タンパク質 / 天然変性領域 / プロテオーム解析 / DYRK-BP / WD40 / DYRK1B / WD40リピート / 細胞情報伝達 / 核移行 / WD40-repeat / ユビキチン / 自己リン酸化 / タンパク質翻訳 / がん / 立体構造 / タンパク質分解 / X線結晶解析 / キナーゼインヒビター / ペプチド / 免疫抑制剤 / FKBP / FK506 / p53 / オリゴマー酵素 / ラージT抗原 / SV40 … More Except Principal Investigator HSP90 / ストレス蛋白質 / カルモデュリン / グルココルチコイド受容体 / 分子シャペロン / カルパイン処理 / SV40ラージT抗原 / カルシウムイオン / アクチン / ダイオキシン受容体 / chaperone / protein degradation / quality control / endoplasmic reticulum / システインプロテアーゼ / シャペロン / タンパク質分解 / クオリティコントロール / 小胞体 / temperature-sensitive mutants / budding yeast / casein kinase II / molecular chaperone / dimerization domain / calmodulin-binding domain / stress proteins / 複合体形成 / カゼインキナ-ゼII / 合成致死変異 / 酵母温度感受性変異株 / アクチン結合タンパク質 / 会合体形成 / 酵素の失活 / 温度感受性変異株 / 出芽酵母 / カゼインキナーゼII / 2量体形成ドメイン / カルモデュリン結合ドメイン / ストレスタンパク質 / ヘキサマー形成 / HSP70 / ルシフェラーゼ / 熱ショック蛋白質 / 免疫共沈殿 / 6量体形成 / カゼインキナーゼ II / がん遺伝子産物 / トランスジェニックマウス / アンチセンスRNA法 / シグナル伝達 / モノクローナル抗体 / GM-CSF / インターロイキン3受容体 / インターロイキン3 / 遺伝子発現 / 核内移行 / 熱ショック蛋白質HSP90 / ステロイドホルモン受容体 Less

Analysis of physiological function of DYRK1A-WDR68 complexPrincipal Investigator
- Principal Investigator
  
  Miyata Yoshihiko
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Kyoto University
Analysis of physiological function of the complex between the Down syndrome kinase DYRK1A and WDR68Principal Investigator
- Principal Investigator
  
  Miyata Yoshihiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyoto University
Ｃｄｃ３７の天然変性領域によるシグナル伝達キナーゼ群の曖昧認識の分子機構の解明Principal Investigator
- Principal Investigator
  
  宮田愛彦
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Identification and functional analyses of cellular proteins that specifically interact with DYRK family protein kinasesPrincipal Investigator
- Principal Investigator
  
  MIYATA Yoshihiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyoto University
シグナル伝達キナーゼの機能を保障するHsp90-Cdc37分子シャペロンの解析Principal Investigator
- Principal Investigator
  
  宮田愛彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Analysis of cellular function of DYRK family protein kinasesPrincipal Investigator
- Principal Investigator
  
  MIYATA Yoshihiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  KYOTO UNIVERSITY
キナーゼのクオリティーコントロールに関わるCdc37の構造と機能の解析Principal Investigator
- Principal Investigator
  
  宮田愛彦
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
HSP90-Cdc37シャペロンによる情報伝達キナーゼのクオリティーコントロールPrincipal Investigator
- Principal Investigator
  
  宮田愛彦
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Analysis of physiological role of protein kinase MOK, a novel member of MAP kinase superfamilyPrincipal Investigator
- Principal Investigator
  
  MIYATA Yoshihiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  KYOTO UNIVERSITY
Identification and functional analysis of a novel type of MAP kinase superfamily.Principal Investigator
- Principal Investigator
  
  MIYATA Yoshihiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  KYOTO UNIVERSITY
ストレス蛋白質HSP90によるがん遺伝子産物機能発現の調節
- Principal Investigator
  
  矢原一郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
カゼインキナーゼIIの活性を細胞内で制御する蛋白質因子の同定と精製Principal Investigator
- Principal Investigator
  
  宮田愛彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
核移行シグナルペプチドによって活性化されるGRP94キナーゼの同定と解析Principal Investigator
- Principal Investigator
  
  宮田愛彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Studies of quality control of proteins in the endoplasmic reticulum.
- Principal Investigator
  
  KITO Makoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Structural biochemistry
- Research Institution
  KYOTO UNIVERSITY
熱ショック蛋白質HSP90とFK506結合蛋白質FKBP52との複合体の解析Principal Investigator
- Principal Investigator
  
  宮田愛彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
ストレス蛋白質によるがん遺伝子産物機能発現の保証機構
- Principal Investigator
  
  矢原一郎
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
熱ショック蛋白質HSP90のSV40ラージT抗原との複合体形成の解析Principal Investigator
- Principal Investigator
  
  宮田愛彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
インターロイキン3受容体の構製とシグナル伝達
- Principal Investigator
  
  矢原一郎
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
HSP90, a stress protein which regulates functional proteins
- Principal Investigator
  
  YAHARA Ichiro
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science
P450、発現を誘導する薬物受容体の細胞内存在様式
- Principal Investigator
  
  矢原一郎
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
P450発現を誘導する薬物の受容体の細胞内存在様式
- Principal Investigator
  
  YAHARA Ichiro
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research

[Book] CK2 Inhibitors and the DYRK Family Protein Kinases. In Advances in Biochemistry in Health and Disease Vol.12: “Protein Kinase CK2 Cellular Function in Normal and Disease States”, Eds. K. Ahmed, O.-G. Issinger, and R. Szyska, pp.341-359. (DOI 10.1007/978-3-319-14544-0_19)2015
- Author(s)
  Miyata, Y.
- Total Pages
  378
- Publisher
  Springer International Publishing Switzerland
- Data Source
  KAKENHI-PROJECT-25440046
[Book] The pivotal role of CK2 in the kinome-targeting Hsp90 chaperone machinery. “The Wiley-IUBMB Series on Biochemistry and Molecular Biology: Protein Kinase CK2”, ed. L.A.Pinna, pp.205-238.2013
- Author(s)
  Miyata, Y.
- Total Pages
  460
- Publisher
  Wiley-Blackwell Publishing (John Wiley & Sons, Inc., Publication)
- Data Source
  KAKENHI-PROJECT-25440046
[Book] The pivotal role of CK2 in the kinome-targeting Hsp90 chaperone machinery. “The Wiley-IUBMB Series on Biochemistry and Molecular Biology: Protein Kinase CK2”, ed. L.A.Pinna, pp.205-2382013
- Author(s)
  Miyata, Y.
- Total Pages
  460
- Publisher
  Wiley-Blackwell Publishing (John Wiley & Sons, Inc., Publication)
- Data Source
  KAKENHI-PUBLICLY-24113714
[Book] The pivotal role of CK2 in the kinome-targeting Hsp90 chaperone machinery. “The Wiley-IUBMB Series on Biochemistry and Molecular Biology: Protein Kinase CK2”, ed. L.A.Pinna2012
- Author(s)
  Miyata Y.
- Total Pages
  460
- Publisher
  Wiley-Blackwell Publishing (John Wiley Sons, Inc., Publication)
- Data Source
  KAKENHI-PUBLICLY-24113714
[Book] シグナル伝達の原理と多様性「医学のための細胞生物学」(永田和宏・塩田浩平編)2009
- Author(s)
  宮田愛彦
- Publisher
  南山堂(印刷中)
- Data Source
  KAKENHI-PROJECT-20570129
[Book] シグナル伝達の原理と多様性「医学のための細胞生物学」2009
- Author(s)
  宮田愛彦
- Total Pages
  315
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-20570129
[Book] 医学のための細胞生物学(永田和宏・塩田浩平編)(南山堂)2009
- Author(s)
  宮田愛彦
- Publisher
  シグナル伝達の原理と多様性
- Data Source
  KAKENHI-PROJECT-20570129
[Book] キーワード:蛋白質の一生(遠藤斗志也・小椋光・永田和宏・森和俊・田口英樹・吉田賢右編)2008
- Author(s)
  宮田愛彦
- Publisher
  Hsp90.蛋白質・核酸・酵素増刊号
- Data Source
  KAKENHI-PROJECT-20570129
[Book] 「Hsp90」蛋白質・核酸・酵素増刊号「キーワード : 蛋白質の一生」(遠藤斗志也・小椋光・永田和宏・森和俊・田口英樹・吉田賢右編)2008
- Author(s)
  宮田愛彦
- Total Pages
  1114
- Publisher
  共立出版
- Data Source
  KAKENHI-PROJECT-20570129
[Journal Article] Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of the kinase DYRK1A2023
- Author(s)
  Miyata Yoshihiko、Nishida Eisuke
- Journal Title
  
  Life Science Alliance
  
  Volume: 6 Issue: 12 Pages: e202302129-e202302129
- DOI
  10.26508/lsa.202302129
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06131
[Journal Article] MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS2023
- Author(s)
  Perez-Cabello Jesus, Silvera-Carrasco Lucia, Franco Jaime, Capilla-Gonzalez Vivian, Armaos Alexandros, Gomez-Lima Maria, Garcia-G. Raquel, Yap Xin Wen, Leal-Lasarte Magdalena, Lall Deepti, Baloh Robert, Martinez Salvador, Miyata Yoshihiko, Tartaglia Gian, Sawarkar Ritwick, Garcia-D. Mario, Pozo David, Roodveldt Cintia
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 28
- DOI
  10.1073/pnas.2302143120
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06131
[Journal Article] Identification of FAM53C as a suppressive binding protein of a neurodevelopmental disorders-related kinase DYRK1A.2023
- Author(s)
  Yoshihiko Miyata and Eisuke Nishida
- Journal Title
  
  BioRxiv
  
  Volume: -
- DOI
  10.1101/2023.04.21.537794
- Open Access
- Data Source
  KAKENHI-PROJECT-18K06131
[Journal Article] Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone.2021
- Author(s)
  Miyata, Y., and Nishida, E.
- Journal Title
  
  Biochimica et Biophysica Acta - Molecular Cell Research
  
  Volume: 1868 Issue: 10 Pages: 119081-119081
- DOI
  10.1016/j.bbamcr.2021.119081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06131
[Journal Article] A cyclic lipopeptide surfactin is a species-selective Hsp90 inhibitor that suppresses cyanobacterial growth2021
- Author(s)
  Hitoshi Nakamoto, Yuhei Yokoyama, Takahiro Suzuki, Yuri Miyamoto, Takashi Fujishiro, Masaaki Morikawa, Yoshihiko Miyata
- Journal Title
  
  J. Biochem.
  
  Volume: － Issue: 2 Pages: 255-264
- DOI
  10.1093/jb/mvab037
- NAID
  40022722358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05407, KAKENHI-PROJECT-18K06131
[Journal Article] Structural characterization of the N-terminal kinase-interacting domain of an Hsp90-cochaperone Cdc37 by CD and solution NMR spectroscopy.2019
- Author(s)
  Ihama, F., Yamamoto, M., Kojima, C., Fujiwara, T., Matsuzaki, K., Miyata, Y., Hoshino, M.
- Journal Title
  
  Biochim. Biophys. Acta-Proteins Proteom.
  
  Volume: 1867 Issue: 9 Pages: 813-820
- DOI
  10.1016/j.bbapap.2019.06.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06131, KAKENHI-PROJECT-18K06151, KAKENHI-PUBLICLY-19H04856, KAKENHI-PROJECT-17H03641
[Journal Article] Stimulation of the ATPase activity of Hsp90 by zerumbone modification of its cysteine residues destabilizes its clients and causes cytotoxicity.2018
- Author(s)
  Nakamoto, H., Amaya, Y., Komatsu, T., Suzuki, T., Dohmae, N., Nakamura, Y., Jantan, I., and Miyata, Y.
- Journal Title
  
  Biochemical Journal
  
  Volume: 475 Issue: 15 Pages: 2559-2576
- DOI
  10.1042/bcj20180230
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06131, KAKENHI-PROJECT-15K07349
[Journal Article] Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells.2015
- Author(s)
  Guerra, B., Rasmussen, T., Schnitzler, A., Jensen, H., Boldyreff, B., Miyata, Y., Marcussen, N., Niefind, K., and Issinger, O.G.
- Journal Title
  
  Cancer Letters
  
  Volume: 356 Issue: 2 Pages: 751-761
- DOI
  10.1016/j.canlet.2014.10.026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440046
[Journal Article] CK2 Inhibitors and the DYRK Family Protein Kinases. In “Protein Kinase CK2 Cellular Function in Normal and Disease States”, Eds. K. Ahmed, O.-G. Issinger, and R. Szyska2015
- Author(s)
  Miyata, Y.
- Journal Title
  
  Advances in Biochemistry in Health and Disease (Springer International Publishing Switzerland)
  
  Volume: 12 Pages: 341-359
- DOI
  10.1007/978-3-319-14544-0_19
- ISBN
  9783319145433, 9783319145440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25440046
[Journal Article] Phosphorylation, signaling, and cancer: Targets and targeting.2015
- Author(s)
  Marmiroli, S., Fabbro, D., Miyata, Y., Pierobon, M., and Ruzzene, M.
- Journal Title
  
  Biomed. Res. Int.
  
  Volume: 2015 Pages: 601543-601543
- DOI
  10.1155/2015/601543
- NAID
  120005745645
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440046
[Journal Article] The Molecular Chaperone TRiC/CCT Binds to the Trp-Asp (WD) 40-repeat Protein WDR68 and Promotes Its Folding, Protein Kinase DYRK1A-binding, and Nuclear Accumulation.2014
- Author(s)
  Miyata, Y., Shibata, T., Aoshima, M., Tsubata, T., and Nishida, E.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 289 Issue: 48 Pages: 33320-33332
- DOI
  10.1074/jbc.m114.586115
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440046
[Journal Article] The therapeutic target Hsp90 and cancer hallmarks2013
- Author(s)
  Miyata, Y., Nakamoto, H., and Neckers, L.
- Journal Title
  
  Current Pharmaceutical Design
  
  Volume: 19 Issue: 3 Pages: 347-365
- DOI
  10.2174/1381612811306030347
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24113714, KAKENHI-PROJECT-24580102, KAKENHI-PROJECT-25440046
[Journal Article] Phosphorylation of CRN2 by CK2 regulates F-actin and Arp2/3 interaction and inhibits cell migration.2012
- Author(s)
  Xavier CP, Rastetter RH, Blomacher M, Stumpf M, Himmel M, Morgan RO, Fernandez MP, Wang C, Osman A, Miyata Y, Gjerset RA, Eichinger L, Hofmann A, Linder S, Noegel AA, and Clemen CS.
- Journal Title
  
  Science Report
  
  Volume: 2 Issue: 1 Pages: 241-254
- DOI
  10.1038/srep00241
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24113714
[Journal Article] Dynamic tyrosine phosphorylation modulates cycling of the Hsp90-p50Cdc37-Aha1 chaperone machine.2012
- Author(s)
  Xu W, Mollapour M, Prodromou C, Wang S, Scroggins BT, Palchick Z, Beebe K, Siderius M, Lee MJ, Couvillon A, Trepel JB, Miyata Y, Matts R, and Neckers L.
- Journal Title
  
  Molecular Cell
  
  Volume: 47 Issue: 3 Pages: 434-443
- DOI
  10.1016/j.molcel.2012.05.015
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24113714
[Journal Article] Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells.2012
- Author(s)
  Zanin S, Borgo C, Girardi C, O'Brien SE, Miyata Y, Pinna LA, Donella-Deana A, and Ruzzene M.
- Journal Title
  
  PLOS One
  
  Volume: 7 Issue: 11 Pages: e49193-e49193
- DOI
  10.1371/journal.pone.0049193
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24113714
[Journal Article] Efficient soluble protein production on transgenic silkworms expressing cytoplasmic chaperones.2010
- Author(s)
  Hong S.M., Yamashita J., Mitsunobu H., Uchino K., Kobayashi I., Sezutsu H., Tamura T., Nakajima H., Miyagawa Y., Lee, J.M., Mon H., Miyata Y., Kawaguchi Y., Kusakabe T.
- Journal Title
  
  Appl.Microbiol. Biotechnol. 87
  
  Pages: 2147-2156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570129
[Journal Article] Efficient soluble protein production on transgenic silkworms expressing cytoplasmic chaperones2010
- Author(s)
  Hong, S.M., Yamashita, J., Mitsunobu, H., Uchino, K., Kobayashi, I., Sezutsu, H., Tamura, T., Nakajima, H., Miyagawa, Y., Lee, J.M., Mon, H., Miyata.Y., Kawaguchi, Y., Kusakabe, T.
- Journal Title
  
  Appl.Microbiol.Biotechnol
  
  Volume: 87 Pages: 2147-2156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570129
[Journal Article] CK2 : The kinase controlling the Hsp90 chaperone machinery.2009
- Author(s)
  Miyata, Y.
- Journal Title
  
  Cellular and Molecular Life Sciences (印刷中)
- Data Source
  KAKENHI-PROJECT-20570129
[Journal Article] Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms.2009
- Author(s)
  Tsuchiya, Y., Akashi, M., Matsuda, M., Goto, K., Miyata, Y., Node, K., Nishida, E.
- Journal Title
  
  Science Signaling (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570129
[Journal Article] CK2 : The kinase controlling the Hsp90 chaperone machinery.2009
- Author(s)
  宮田愛彦
- Journal Title
  
  Cell. Mol. Life Sci. 66(総説)
  
  Pages: 1840-1849
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570129
[Journal Article] Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms.2009
- Author(s)
  Tsuchiya Y., Akashi M., Matsuda M., Goto K., Miyata Y., Node K., Nishida E.
- Journal Title
  
  Science Signaling 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570129
[Journal Article] Involvement of the protein kinase CK2 in the regulation of mammalian circadian rhythms.2009
- Author(s)
  Tsuchiya, Y., Akashi, M., Matsuda, M., Goto, K., Miyata, Y., Node, K., Nishida, E.
- Journal Title
  
  Science Signaling 2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570129
[Journal Article] CK2 : The kinase controlling the Hap90 chaperone machinery.2009
- Author(s)
  Miyata, Y.
- Journal Title
  
  Cellular and Molecular Life Sciences 66
  
  Pages: 1840-1849
- Data Source
  KAKENHI-PROJECT-20570129
[Journal Article] Evaluating CK2 activity with the antibody specific for the CK2-phosphorylated form of a kinase-targeting cochaperone Cdc37.2008
- Author(s)
  Miyata Y., Nishida E.
- Journal Title
  
  Mol. Cell. Biochem. 316
  
  Pages: 127-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570129
[Journal Article] Evaluating CK2 activity with the antibody specific for the CK2-phosphorylated form of a kinase-targeting cochaperone Cdc37.2008
- Author(s)
  Miyata, Y., Nishida, E.
- Journal Title
  
  Molecular and Cellular Biochemistry 316
  
  Pages: 127-134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570129
[Journal Article] 分子シャペロンHsp90阻害薬(ゲルダナマイシン)2005
- Author(s)
  宮田愛彦
- Journal Title
  
  癌治療と宿主特集「癌の分子標的治療の進歩」 17
  
  Pages: 277-281
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570110
[Journal Article] CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37,an Hsp90-cochaperone.2005
- Author(s)
  Y.Miyata, E.Nishida
- Journal Title
  
  Molecular and Cellular Biochemistry (In press)
- Data Source
  KAKENHI-PROJECT-15032225
[Journal Article] 分子シャペロンHsp90阻害薬(ゲルダナマイシン)2005
- Author(s)
  宮田愛彦
- Journal Title
  
  癌治療と宿主 17
  
  Pages: 277-281
- Data Source
  KAKENHI-PROJECT-17028030
[Journal Article] Hsp90 Inhibitor Geldanamycin and Its Derivatives as Novel Cancer Chemotherapeutic Agents.2005
- Author(s)
  Miyata, Y.
- Journal Title
  
  Current Pharmaceutical Design 11
  
  Pages: 1131-1138
- Data Source
  KAKENHI-PROJECT-17028030
[Journal Article] Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chermotherapeutic agents.2005
- Author(s)
  Y.Miyata
- Journal Title
  
  Current Pharmaceutical Design 11
  
  Pages: 1131-1138
- Data Source
  KAKENHI-PROJECT-15032225
[Journal Article] An inhibitor of the molecular chaperone Hsp90 (geldanamycin) (in Japanese)2005
- Author(s)
  Miyata, Y.
- Journal Title
  
  Frontiers in Cancer Treatment 17
  
  Pages: 277-281
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570110
[Journal Article] CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperone.2005
- Author(s)
  Miyata, Y., Nishida, E.
- Journal Title
  
  Molecular and Cellular Biochemistry 274
  
  Pages: 171-179
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570110
[Journal Article] 分子シャペロンHsp90阻害薬(ゲルダナマイシン)2005
- Author(s)
  宮田愛彦
- Journal Title
  
  癌治療と宿主 17
  
  Pages: 277-281
- Data Source
  KAKENHI-PROJECT-17570110
[Journal Article] Hsp90 Inhibitor Geldanamycin and Its Derivatives as Novel Cancer Chemotherapeutic Agents.2005
- Author(s)
  Miyata, Y.
- Journal Title
  
  Current Pharmaceutical Design 11
  
  Pages: 1131-1138
- Data Source
  KAKENHI-PROJECT-17570110
[Journal Article] CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperone.2005
- Author(s)
  Miyata, Y., Nishida, E.
- Journal Title
  
  Molecular and Cellular Biochemistry 274
  
  Pages: 171-179
- Data Source
  KAKENHI-PROJECT-17028030
[Journal Article] 細胞内シグナル伝達分子の生成と機能発現にかかわるHsp902004
- Author(s)
  宮田愛彦
- Journal Title
  
  蛋白質・核酸・酵素 49・7
  
  Pages: 862-866
- Data Source
  KAKENHI-PROJECT-15032225
[Journal Article] CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.2004
- Author(s)
  Y.Miyata, B.Nishida
- Journal Title
  
  Molecular and Cellular Biology 24・9
  
  Pages: 4065-4074
- Data Source
  KAKENHI-PROJECT-15032225
[Journal Article] Supervision of multiple signaling protein kinases by the CK2-Cdc37 couple, a possible novel cancer therapeutic target.2004
- Author(s)
  Y.Miyata, E.Nishida
- Journal Title
  
  Annals of the New York Academy of Sciences 1030
  
  Pages: 150-157
- Data Source
  KAKENHI-PROJECT-15032225
[Presentation] Identification of FAM53C as a novel regulatory binding protein of DYRK1A2022
- Author(s)
  Yoshihiko Miyata and Eisuke Nishida
- Organizer
  International conference "DYRK1A, related kinases and human disease"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06131
[Presentation] Functional regulation of DYRK1A, a kinase intimately involved in Down syndrome and autism spectrum disorder, by cellular binding partners.2018
- Author(s)
  Yoshihiko Miyata
- Organizer
  Seminar at Institut de Genetique et de Biologie Moleculaire et Cellulaire (Illkirch, France)
- Invited
- Data Source
  KAKENHI-PROJECT-18K06131
[Presentation] Hsp90 molecular chaperone, signaling protein kinases, and cancer.2018
- Author(s)
  Yoshihiko Miyata
- Organizer
  Seminar at Institut de Biologie Moleculaire et Cellulaire, Universite de Strasbourg (Strasbourg, France)
- Invited
- Data Source
  KAKENHI-PROJECT-18K06131
[Presentation] Essential role of TRiC/CCT in folding and function of a DYRK1A-binding WD40-repeat protein WDR682015
- Author(s)
  Miyata, Y., Shibata, T., Aoshima, M., Tsubata, T., and Nishida, E.
- Organizer
  Gordon Research Conference on “Stress Proteins in Growth, Development and Disease”
- Place of Presentation
  Lucca-Barga, Italy
- Year and Date
  2015-07-05
- Data Source
  KAKENHI-PROJECT-25440046
[Presentation] The Pivotal Role of A Molecular Chaperone Hsp90 for Cellular Signaling Protein Kinases2015
- Author(s)
  Miyata, Y.
- Organizer
  Seminar in Hungarian Academy of Sciences, Biological Research Center, Institute of Biochemistry
- Place of Presentation
  Szeged, Hungary
- Year and Date
  2015-10-05
- Invited
- Data Source
  KAKENHI-PROJECT-25440046
[Presentation] The Pivotal Role of A Molecular Chaperone Hsp90 for Cellular Signaling Protein Kinases2015
- Author(s)
  Miyata, Y.
- Organizer
  The 17th symposium, Graduate School of Biostudies, Kyoto University (第17回京都大学・大学院生命科学研究科シンポジウム)
- Place of Presentation
  京都市
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-25440046
[Presentation] Interaction of Hsp90 and Cdc37 with specific members of the DYRK/Minibrain family protein kinases2015
- Author(s)
  Miyata, Y.
- Organizer
  Seminar in Semmelweis University, Department of Medical Chemistry
- Place of Presentation
  Budapest, Hungary
- Year and Date
  2015-10-07
- Invited
- Data Source
  KAKENHI-PROJECT-25440046
[Presentation] TRiC/CCTはWD40リピートタンパク質WDR68の高次構造形成・DYRK1A結合・核局在に必須の分子シャペロンである (Essential role of TRiC/CCT chaperone in folding and function of a DYRK1A-binding WD40-repeat protein WDR68)2015
- Author(s)
  宮田愛彦、柴田猛、青島理人、津幡卓一、西田栄介
- Organizer
  BMB2015 (第38回日本分子生物学会年会、第88回日本生化学会大会)
- Place of Presentation
  神戸市
- Year and Date
  2015-12-03
- Data Source
  KAKENHI-PROJECT-25440046
[Presentation] Functional regulation of different DYRK family protein kinase members by distinctive cellular binding partners including Hsp90, Cdc37, and WDR68.2012
- Author(s)
  Miyata Y, and Nishida E.
- Organizer
  The 4th EMBO Meeting 2012
- Place of Presentation
  Nice, France
- Year and Date
  2012-09-24
- Data Source
  KAKENHI-PUBLICLY-24113714
[Presentation] タンパク質キナーゼDYRK群の細胞内結合タンパク質による特異的制御機構2012
- Author(s)
  宮田愛彦、西田栄介
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  博多
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PUBLICLY-24113714
[Presentation] A possible role of CK2 in protein nuclear translocation signalling2010
- Author(s)
  Miyata.Y., Nishida, E.
- Organizer
  6th International Conference on Protein Kinase CK2
- Place of Presentation
  Wahn Castle, Cologne, Germany(招待講演)
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] A possible role of CK2 in protein nuclear translocation signalling2010
- Author(s)
  宮田愛彦, 西田栄介
- Organizer
  6th International Conference on Protein Kinase CK2
- Place of Presentation
  Cologne, Germany(招待口演)
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] ダウン症候群に関連するDYRK1Aキナーゼは高度に保存されたWD40タンパク質WDR68と特異的に結合してその核移行を促進する2010
- Author(s)
  宮田愛彦、西田栄介
- Organizer
  BMB2010 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸(ポスター発表)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] ダウン症候群に関連するDYRK1Aキナーゼは高度に保存されたWD40タンパク質WDR68と特異的に結合してその核移行を促進する2010
- Author(s)
  宮田愛彦、西田栄介
- Organizer
  BMB2010第33回日本分子生物学会年会第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] CK2によるCdc37のリン酸化を介したkinome制御2009
- Author(s)
  宮田愛彦, 西田栄介
- Organizer
  キナーゼシグナル研究会
- Place of Presentation
  北里大学薬学部(東京)
- Year and Date
  2009-03-21
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] An authentic molecular chaperone activity of Hsp90 and Cdc37 for the signaling protein kinases DYRKs2009
- Author(s)
  宮田愛彦, 西田栄介
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Sapporo, Japan(ワークショップ口頭発表及びポスター発表)
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] An authentic molecular chaperone activity of Hsp90 and Cdc37 for the signaling protein kinases DYRKS.2009
- Author(s)
  Miyata, Y., Nishida, E.
- Organizer
  The 4th International Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] Hsp90のキナーゼ特異的コシャペロンCdc37に対するリン酸化認識抗体を用いたCK2活性変動の解析2009
- Author(s)
  宮田愛彦、西田栄介
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] Hsp90のキナーゼ特異的コシャペロンCdc37に対するリン酸化認識抗体を用いたCK2活性変動の解析2009
- Author(s)
  宮田愛彦、西田栄介
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸(ポスター発表及び口頭発表)
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] キナーゼ特異的Hsp90コシャペロンCdc37のCK2によるリン酸化-リン酸化特異的抗体及びリン酸基アフィニティーゲル電気泳動による解析2008
- Author(s)
  宮田愛彦, 西田栄介
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会合同大会(BMB2008)
- Place of Presentation
  神戸ポートアイランド(神戸)
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] マス・スペクトルによるシグナル伝達キナーゼ複合体の網羅的リン酸化プロテオーム解析2008
- Author(s)
  宮田愛彦
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会合同大会(BMB2008)バイオテクノロジーセミナー
- Place of Presentation
  神戸ポートアイランド(神戸)
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] マス・スペクトルによるシグナル伝達キナーゼ複合体の網羅的リン酸化プロテオーム解析2008
- Author(s)
  宮田愛彦
- Organizer
  BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同年会テクニカルセミナー「網羅的リン酸化解析を可能にする"最先端"質量分析テクノロジー」
- Place of Presentation
  神戸(招待講演)
- Year and Date
  2008-12-10
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] キナーゼ特異的Hsp90コシャペロンCdc37のCK2によるリン酸化-リン酸化特異的抗体及びリン酸基アフィニティーゲル電気泳動による解析2008
- Author(s)
  宮田愛彦、西田栄介
- Organizer
  BMB2008第31回日本分子生物学会年会・第81回日本生化学会大会合同年会
- Place of Presentation
  神戸(ポスター発表)
- Data Source
  KAKENHI-PROJECT-20570129
[Presentation] DYRKファミリーキナーゼとキナーゼシグナルを媒介するWDR68
- Author(s)
  宮田愛彦
- Organizer
  蛋白研セミナー「キナーゼ・シグナリング研究の進展」
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PUBLICLY-24113714
[Presentation] Functional regulation of DYRK family protein kinases by cellular binding partners
- Author(s)
  Miyata, Y., and Nishida, E.
- Organizer
  7th International Conference on Protein Kinase CK2
- Place of Presentation
  Lublin, Poland
- Invited
- Data Source
  KAKENHI-PUBLICLY-24113714
[Presentation] DYRKファミリーキナーゼの細胞内結合タンパク質による機能制御
- Author(s)
  宮田愛彦、西田栄介
- Organizer
  第36回日本分子生物学会年会ワークショップ「キナーゼ・シグナルから生理機能へ」
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PROJECT-25440046
[Presentation] DYRKファミリーキナーゼとキナーゼシグナルを媒介するWDR68
- Author(s)
  宮田愛彦
- Organizer
  蛋白研セミナー「キナーゼ・シグナリング研究の進展」
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-25440046
[Presentation] DYRKファミリーキナーゼの細胞内結合タンパク質による機能制御
- Author(s)
  宮田愛彦、西田栄介
- Organizer
  第36回日本分子生物学会年会ワークショップ「キナーゼ・シグナルから生理機能へ」
- Place of Presentation
  神戸
- Invited
- Data Source
  KAKENHI-PUBLICLY-24113714
[Presentation] Functional regulation of DYRK family protein kinases by cellular binding partners
- Author(s)
  Miyata, Y., and Nishida, E.
- Organizer
  7th International Conference on Protein Kinase CK2
- Place of Presentation
  Lublin, Poland
- Invited
- Data Source
  KAKENHI-PROJECT-25440046

1. YAHARA Ichiro (60109957)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. MINAMI Yasufumi (40181953)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. IIDA Kazuko (40151229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MATSUMOTO Seiji (40190532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KITO Makoto (60027183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SATO Ryuichiro (50187259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKANO Akihiko (90142140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOHNO Kenji (50142005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IKEHARA Yukio (70037612)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KIKUCHI Masakazu (10278492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 米原美奈子 (10124471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 石井愛 (80124436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小安重夫 (90153684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 久下理 (30177977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 仲本準

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miyata Yoshihiko 宮田 愛彦

MIYATA Yoshihiko 宮田 愛彦

Research Projects

Research Products

Co-Researchers

Analysis of physiological function of DYRK1A-WDR68 complexPrincipal Investigator

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Analysis of physiological function of the complex between the Down syndrome kinase DYRK1A and WDR68Principal Investigator

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Ｃｄｃ３７の天然変性領域によるシグナル伝達キナーゼ群の曖昧認識の分子機構の解明Principal Investigator

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Identification and functional analyses of cellular proteins that specifically interact with DYRK family protein kinasesPrincipal Investigator

Principal Investigator

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シグナル伝達キナーゼの機能を保障するHsp90-Cdc37分子シャペロンの解析Principal Investigator

Principal Investigator

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Analysis of cellular function of DYRK family protein kinasesPrincipal Investigator

Principal Investigator

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キナーゼのクオリティーコントロールに関わるCdc37の構造と機能の解析Principal Investigator

Principal Investigator

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Research Institution

HSP90-Cdc37シャペロンによる情報伝達キナーゼのクオリティーコントロールPrincipal Investigator

Principal Investigator

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Analysis of physiological role of protein kinase MOK, a novel member of MAP kinase superfamilyPrincipal Investigator

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Identification and functional analysis of a novel type of MAP kinase superfamily.Principal Investigator

Principal Investigator

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ストレス蛋白質HSP90によるがん遺伝子産物機能発現の調節

Principal Investigator

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カゼインキナーゼIIの活性を細胞内で制御する蛋白質因子の同定と精製Principal Investigator

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核移行シグナルペプチドによって活性化されるGRP94キナーゼの同定と解析Principal Investigator

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Project Period (FY)

Research Category

Miyata Yoshihiko 宮田愛彦

MIYATA Yoshihiko 宮田愛彦

[Book] シグナル伝達の原理と多様性「医学のための細胞生物学」(永田和宏・塩田浩平編)2009