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HORIGUCHI Takashi  堀口 剛

ORCIDConnect your ORCID iD *help
Researcher Number 70221570
External Links
Affiliation (based on the past Project Information) *help 2018 – 2019: 秋田大学, 医学部附属病院, 准教授
2007 – 2017: 秋田大学, 医学部, 准教授
1990 – 1991: 秋田大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Anesthesiology/Resuscitation studies / Anesthesiology
Except Principal Investigator
Anesthesiology / 麻酔学 / Anesthesiology/Resuscitation studies
Keywords
Principal Investigator
術後認知機能障害 / 高齢者 / 脳 / セボフルラン / 吸入麻酔薬 / NMDA受容体 / シナプス可塑性 / depotentiation / LTP / 硫化水素 … More / 国際情報交換 / 吸入麻酔 / 手術 / 血管新生 / 微細構造 / 術後認知機能 / SIM分析 / 内部標準法 / ガスクロマトグラフ / 血液 / イソフルラン / プロポフォール / 術後認知機能低下 / 麻酔学 … More
Except Principal Investigator
高次脳機能障害 / アポトーシス / リチウム / デクスメデトミジン / キセノン / セボフルラン / 全身麻酔 / 認知機能障害 / 新奇物体認識試験 / 手術 / 炎症性サイトカイン / rabbit / goat / heparin・protamine complex / protamine / thromboxane / pulmonary intravascular macrophages / 肺高血圧 / 肺血管内マクロフィ-ジ / 家兎 / 山羊 / ヘパリン・プロタミン複合体 / プロタミン / トロンボキサン / 肺血管内マクロファ-ジ / 神経毒性 / α2受容体作動薬 / 術後認知機能障害 / 肺虚血再灌流障害 / 吸入麻酔薬 Less
  • Research Projects

    (7 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (10 People)
  •  The role and effect of hydrogen sulfate on the postoperative cognitive dysfunctionPrincipal Investigator

    • Principal Investigator
      Horiguchi Takashi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Akita University
  •  Preventive measures against cognitive dysfunction following general anesthesia

    • Principal Investigator
      Nishikawa Toshiaki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Akita University
  •  Preventive measures against cognitive dysfunction following general anesthesia

    • Principal Investigator
      Nishikawa Toshiaki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology
    • Research Institution
      Akita University
  •  Mechanisms of postoperative cognitive dysfunction after inhalation of volatile anestheticsPrincipal Investigator

    • Principal Investigator
      Horiguchi Takashi
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Akita University
  •  Mechanisms of postoperative cognitive dysfunction after inhalation anesthesiaPrincipal Investigator

    • Principal Investigator
      HORIGUCHI Takashi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Akita University
  •  Protective effect of volatile anesthetics on ischemic-reperfusion injury of lung

    • Principal Investigator
      ABE Kyoko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Akita University
  •  Mechanism of Pulmonary Arterial Hypertension after Protamine Reversal

    • Principal Investigator
      ENZAN Keiji
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      麻酔学
    • Research Institution
      Akita University

All 2019 2018 2016 2015 2014 2012 2011 2010 2009 Other

All Journal Article Presentation

  • [Journal Article] セボフルラン麻酔後の脳内・血液内のセボフルラン量2009

    • Author(s)
      堀口剛, 真崎容子, 西川俊昭
    • Journal Title

      神経麻酔・集中治療2009

      Pages: 59-60

    • Data Source
      KAKENHI-PROJECT-21591968
  • [Journal Article] セボフルラン麻酔後の脳内・血液内のセボフルラン量2009

    • Author(s)
      堀口剛
    • Journal Title

      神経麻酔・集中治療

      Pages: 59-60

    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] 高齢ラットにおける吸入麻酔薬濃度の違いによる術後認知機能への影響2019

    • Author(s)
      山本夏子,堀口剛,西川俊昭,藤井聡
    • Organizer
      第23回神経麻酔集中治療学会
    • Data Source
      KAKENHI-PROJECT-17K11043
  • [Presentation] Effects of surgery under anesthesia with different concentrations of sevoflurane on the acquisition of spatial memory in adult rats.2018

    • Author(s)
      Yamamoto N, Horiguchi, T., Nishikawa, T.
    • Organizer
      The European Anaesthesiology Congress 2014
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11043
  • [Presentation] Angiogenesis in the brain after sevoflurane anesthesia in rats.2016

    • Author(s)
      Horiguchi T, Masaki Y, Kawamura K, Nishikawa T
    • Organizer
      The European Anaesthesiology Congress
    • Place of Presentation
      London, UK
    • Year and Date
      2016-05-28
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-24592292
  • [Presentation] セボフルラン麻酔による脳の微細構造の変化2015

    • Author(s)
      堀口 剛、真崎 容子、川村 公一、西川 俊昭
    • Organizer
      第19回日本神経麻酔集中治療学会
    • Place of Presentation
      岐阜
    • Year and Date
      2015-04-10
    • Data Source
      KAKENHI-PROJECT-24592292
  • [Presentation] イソフルラン麻酔後の各臓器におけるイソフルラン濃度2015

    • Author(s)
      真崎 容子、堀口 剛、西川 俊昭
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-05-28
    • Data Source
      KAKENHI-PROJECT-24592292
  • [Presentation] イソフルラン麻酔後の脳内濃度変化2015

    • Author(s)
      真崎 容子、堀口 剛、西川 俊昭
    • Organizer
      日本蘇生学会第34回大会
    • Place of Presentation
      秋田
    • Year and Date
      2015-11-04
    • Data Source
      KAKENHI-PROJECT-24592292
  • [Presentation] セボフルラン麻酔直後における脳、肝臓の微細構造変化2014

    • Author(s)
      真崎容子、堀口剛、西川俊昭
    • Organizer
      日本麻酔科学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24592292
  • [Presentation] Ultrastructural changes in the brain cells after discontinuation of sevoflurane anesthesia in rats2014

    • Author(s)
      Horiguchi T, Masaki Y, Kawamura K, Nishikawa T
    • Organizer
      Euroanaesthesia
    • Place of Presentation
      Sweden, Stockholm
    • Data Source
      KAKENHI-PROJECT-24592292
  • [Presentation] Residual concentrations of propofol in the blood and brain afteradministration in rats2012

    • Author(s)
      Horiguchi T, Masaki Y, Nishikawa T
    • Organizer
      15th WFSA World Congress of Anaesthesiologists
    • Place of Presentation
      La Rural, Buenos Aires, Argentina
    • Year and Date
      2012-03-27
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] Comparative Residual concentrations of isoflurane and sevoflurane in blood and brain after anesthesia in Rats.2012

    • Author(s)
      Horiguchi T, Masaki Y, Muto H, Nishikawa T, Tobe Y
    • Organizer
      The 65th American Society of Anesthesiologist, Annual Meeting
    • Place of Presentation
      Washington DC
    • Data Source
      KAKENHI-PROJECT-24592292
  • [Presentation] Residual concentrations of propofol in the blood and brain after administration in rats2012

    • Author(s)
      Horiguchi T, Masaki Y, Nishikawa T
    • Organizer
      15th WFSA World Congress of Anaesthesiologists
    • Place of Presentation
      Buenos Aires, Argentina
    • Year and Date
      2012-03-27
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] セボフルラン麻酔後の血中残存セボフルラン濃度2011

    • Author(s)
      堀口剛、真崎容子、西川俊昭
    • Organizer
      日本臨床麻酔学会第31回大会
    • Place of Presentation
      沖縄コンベンションセンター(宜野湾市)
    • Year and Date
      2011-11-05
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] Residual concentration of sevoflurane in blood after sevoflurane anesthesia in humans2011

    • Author(s)
      Horiguchi T, Masaki Y, Muto H, Nishikawa T
    • Organizer
      The 64th American Society of Anesthesiologists (ASA) Annual Meeting
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2011-10-18
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] Residual concentration of sevoflurane in blood after sevoflurane anesthesia in humans2011

    • Author(s)
      Horiguchi T, Masaki Y, Nishikawa T
    • Organizer
      The 64th American Society of Anesthesiologist, Annual Meeting
    • Place of Presentation
      McComick place convention center, Chicago, IL, USA
    • Year and Date
      2011-10-18
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] プロポフォール麻酔2日後の脳内プロポフォール濃度2011

    • Author(s)
      堀口剛, 真崎容子, 西川俊昭
    • Organizer
      日本麻酔科学会第58回大会
    • Place of Presentation
      神戸
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] プロポフォール麻酔2日後の脳内プロポフォール濃度2011

    • Author(s)
      堀口剛、真崎容子、西川俊昭
    • Organizer
      日本麻酔科学会第58回大会
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] セボフラン麻酔後の血中残存セボフルラン濃度2011

    • Author(s)
      堀口剛, 真崎容子, 西川俊昭
    • Organizer
      日本臨床麻酔学会第31回大会
    • Place of Presentation
      宜野湾
    • Year and Date
      2011-11-05
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] セボフルラン麻酔後2目目の血中セボフルラン濃度2010

    • Author(s)
      堀口剛
    • Organizer
      日本臨床麻酔学会第30回大会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-04
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] Residual concentration of sevoflurane in brain after sevoflurane anesthesia differed among ages in rats2010

    • Author(s)
      Horiguchi T
    • Organizer
      The 63nd American Society of Anesthesiologist, Annual Meeting
    • Place of Presentation
      San Diego Convention Center, San Diego, CA, USA
    • Year and Date
      2010-10-19
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] セボフルラン麻酔後2日目の血中セボフルラン濃度2010

    • Author(s)
      堀口剛, 真崎容子, 西川俊昭
    • Organizer
      日本臨床麻酔学会第30回大会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-04
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] トと成年ラットにおけるセボフルラン麻酔後2日目の脳内セボフルラン残存の有無2010

    • Author(s)
      堀口剛, 真崎容子, 西川俊昭
    • Organizer
      日本麻酔科学会第57回大会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-04
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] Residual concentration of sevoflurane in brain after sevoflurane anesthesia differed among ages in rats2010

    • Author(s)
      Horiguchi T, Masaki Y, Nishikawa T, Tobe Y
    • Organizer
      The 63th American Society of Anesthesiologists (ASA) Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2010-10-19
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] 新生ラットと成年ラットにおけるセボフルラン麻酔後2日目の脳内セボフルラン残存の有無2010

    • Author(s)
      堀口剛
    • Organizer
      日本麻酔科学会第57回大会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-04
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] Histological changes and acquisition of spatial memory after sevoflurane anesthesia in rats.2009

    • Author(s)
      堀口剛
    • Organizer
      The 62nd American Society of Anesthesiologist, Annual Meeting
    • Place of Presentation
      New Orleans Morial Convention Center, New Orleans, LA, USA
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] Histological changes and acquisition of spatial memory after sevoflurane anesthesia in rats2009

    • Author(s)
      Horiguchi, T, Masaki, Y, Nishikawa, T, Tobe, Y
    • Organizer
      The 62th American Society of Anesthesiologists (ASA) Annual Meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] 高齢ラットではセボフルラン麻酔後、セボフルランは脳内に長期間残存する2009

    • Author(s)
      堀口剛, 真崎容子, 西川俊昭
    • Organizer
      日本麻酔科学会第56回大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-08-17
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] Residual concentration of sevoflurane in blood and brain after sevoflurane anesthesia in rats2009

    • Author(s)
      Horiguchi, T, Masaki, Y, Nishikawa, T, Tobe, Y
    • Organizer
      The 62th American Society of Anesthesiologists (ASA) Annual Meeting
    • Place of Presentation
      New Orleans, LA, USA
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] Residual concentration of sevoflurane in blood and brain after sevoflurane anesthesia in rats.2009

    • Author(s)
      堀口剛
    • Organizer
      The 62nd American Society of Anesthesiologist, Annual Meeting
    • Place of Presentation
      New Orleans Morial Convention Center, New Orleans, LA, USA
    • Year and Date
      2009-10-18
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] 高齢ラットではセボフルラン麻酔後、セボフルランは脳内に長期間残存する2009

    • Author(s)
      堀口剛
    • Organizer
      日本麻酔科学会第56回大会
    • Place of Presentation
      神戸国際展示場(神戸市)
    • Year and Date
      2009-08-17
    • Data Source
      KAKENHI-PROJECT-21591968
  • [Presentation] Ultrastructural changes in the brain cells after discontinuation of sevoflurane anesthesia in rats.

    • Author(s)
      Horiguchi T, Masaki Y, Kawamura K, Nishikawa T
    • Organizer
      The European Anaesthesiology Congress 2014
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2014-05-31 – 2014-06-03
    • Data Source
      KAKENHI-PROJECT-24592292
  • [Presentation] セボフルラン麻酔直後における脳、肝臓の微細構造変化

    • Author(s)
      真崎容子,堀口 剛,川村公一,西川俊昭
    • Organizer
      日本麻酔科学会第61回大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-05-16 – 2014-05-17
    • Data Source
      KAKENHI-PROJECT-24592292
  • 1.  NISHIKAWA Toshiaki (50156048)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 26 results
  • 2.  MASAKI Yoko (30125744)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 24 results
  • 3.  ABE Kyoko (30311575)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  KAWAMURA Koichi (00091801)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 5.  KIMURA Tetsu (00312702)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  GOYAGI Toru (30302277)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  ENZAN Keiji (80125707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MITSUHATA Hiromasa (70108934)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  山本 夏子 (40771514)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 10.  藤井 聡 (80173384)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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