akiyama yasuto 秋山靖人

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AKIYAMA Yasuto 秋山靖人

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Researcher Number	70222552
Other IDs
Affiliation (Current)	2025: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2016 – 2024: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 2018: 静岡県立静岡がんセンター(研究所), その他部局等, 副所長 2016 – 2017: 静岡県立静岡がんセンター(研究所), その他部局等, 副研究所長 2013 – 2015: 静岡県立静岡がんセンター(研究所), その他部局等, その他 2014: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 … More 2014: 静岡県立静岡がんセンター, 免疫治療研究部, 部長 2014: 静岡県立静岡がんセンター研究所 2012: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 2010 – 2011: 静岡県立静岡がんセンター(研究所), 免疫治療研究部, 部長 2009: Shizuoka Cancer Center Research Institute, 研究所・免疫治療研究部, 部長 2006 – 2008: 静岡県立静岡がんセンター(研究所), 免疫治療研究部, 部長 Less
Review Section/Research Field	Principal Investigator Science and Engineering / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor diagnostics / Tumor therapeutics / Dermatology Except Principal Investigator Tumor therapeutics / Plastic surgery / Basic Section 56070:Plastic and reconstructive surgery-related / Basic Section 90130:Medical systems-related / Clinical oncology
Keywords	Principal Investigator がん免疫療法 / 次世代シークエンサー / 腫瘍内浸潤リンパ球 / 免疫学 / 遺伝子スクリーニング / 免疫細胞 / 1細胞蛍光検出 / がんゲノム解析 / ドライバー変異 / ゲノム編集 … More / HLAタイピング / がんドライバー遺伝子変異 / MHC安定化試験 / がんのドライバー変異 / ネオアンチゲン / マイクロアレイ / ゲノム / 癌 / がんエクソーム解析 / 免疫チェックポイント抗体 / 免疫応答関連遺伝子 / がんエキソーム解析 / 高頻度遺伝子変異腫瘍 / T細胞受容体 / Hypermutator / ヒトモノクローナル抗体 / ヒト化マウス / 悪性グリオーマ / がん性幹細胞 / 抗体医薬 / プロテオーム / バイオマーカー / メラノーマ / 遺伝子クローニング … More Except Principal Investigator 腫瘍免疫 / マウスモデル / グリオーマ / 悪性腫瘍 / 免疫皮弁 / 免疫療法 / 樹状細胞 / 皮弁 / 国際共同研究 / 異分野共同研究 / 移植医療 / 機能再建 / 複合組織移植 / メラノーマ / 遺伝子変異がん細胞 / 循環がん細胞 / 核酸プローブ / 細胞チップ / 1細胞解析 / 抗がん剤 / 類縁体合成 / 低分子化合物 / 増殖抑制 / 脳腫瘍 / 悪性脳腫瘍 / NOGマウス / CD3 / T細胞 / PD-L1 / ヒト化マウスモデル / 乳癌 / 二重特異性抗体 / B7-H4 / リンパ節 / ブタ / リンパ管静脈吻合 / リンパ管 / 癌精巣抗原 / 変異抗原 / 遊離組織移植 / 乳房再建 / 頭頸部再建 / 遊離皮弁 / がん免疫療法 / 形成外科 / 国際情報交換 / がん幹細胞治療薬 Less

Collaborative research for novel vascularized composite transplantation
- Principal Investigator
  
  荒木淳
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Shizuoka Cancer Center Research Institute
Development of on-chip cancer diagnostic system using high-integrated cell chips and nucleic acid probes
- Principal Investigator
  
  山村昌平
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Development of driver mutation-specific novel neoantigen vaccines based on cancer genome analysisPrincipal Investigator
- Principal Investigator
  
  Akiyama Yasuto
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shizuoka Cancer Center Research Institute
Immune response-associated gene expression profiling for biomarker development in hypermutated tumorsPrincipal Investigator
- Principal Investigator
  
  Akiyama Yasuto
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Shizuoka Cancer Center Research Institute
Bispesific-antibody targeting B7-H4
- Principal Investigator
  
  Iizuka Akira
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Shizuoka Cancer Center Research Institute
Study of novel salicylic acid analogs for anti brain tumor reagent
- Principal Investigator
  
  Ando Takayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Shizuoka Institute of Environment and Hygiene
Novel cancer immunotherapy: Application of Immuno-flap
- Principal Investigator
  
  Inoue Keita
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Jichi Medical University
  Shizuoka Cancer Center Research Institute
Anti-tumor immunotherapy in humanized the NOG-MHC double knockout mouse
- Principal Investigator
  
  Iizuka Akira
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Shizuoka Cancer Center Research Institute
Development of novel human antibody against malignant glioma-derived stem cellPrincipal Investigator
- Principal Investigator
  
  Akiyama Yasuto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Shizuoka Cancer Center Research Institute
Development of a novel small-molecule compounds targeting cancer stem cells derived from malignant glioma
- Principal Investigator
  
  ASHIZAWA Tadashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Shizuoka Cancer Center Research Institute
Immunologically augmented skin flap as a novel dendritic cell vaccine against head and neck cancer in a rat model
- Principal Investigator
  
  INOUE Keita
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Plastic surgery
- Research Institution
  Shizuoka Cancer Center Research Institute
Identification of melanoma-specific serum biomarker and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Yasuto
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Shizuoka Cancer Center Research Institute
1細胞蛍光検出技術を用いた腫瘍内がん特異的免疫細胞の遺伝子スクリーニング法の開発Principal Investigator
- Principal Investigator
  
  秋山靖人
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Shizuoka Cancer Center Research Institute
1細胞蛍光検出技術を用いたがん特異的免疫細胞の遺伝子スクリーニング法の開発Principal Investigator
- Principal Investigator
  
  秋山靖人
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Shizuoka Cancer Center Research Institute

[Book] Novel approach to the characterization of melanoma-peptide-specific CTL lines from metastatic melanoma patients2011
- Author(s)
  Akiyama Y, et al
- Total Pages
  495
- Publisher
  Intech
- Data Source
  KAKENHI-PROJECT-21591451
[Book] Chaper23 : Novel approach to the characterization of melanoma-peptide-specific CTL lines from metastatic melanoma patients. Breakthroughs in melanoma research, ISBN 978-953-307-291-32011
- Author(s)
  Yasuto Akiyama
- Publisher
  INTECH
- Data Source
  KAKENHI-PROJECT-21591451
[Book] シングルセル解析の最前線第4章mRNAをターゲットとしたデジタル精密計測技術の開発10.1細胞分離技術を用いたがん特異的免疫細胞の遺伝子スクリーニング法の開発2010
- Author(s)
  秋山靖人、新垣篤史
- Total Pages
  274
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] Localization of EGFR mutations in non-small cell lung cancer tissues using mutation-specific DNA-PNA probes2023
- Author(s)
  Shigeto H, Miyata H, Ashizawa T, Iizuka A, Kikuchi Y, Hozumi C, Maeda C, Yamaguchi K, Yamamura S, Akiyama Y
- Journal Title
  
  Cancer Genomics Proteomics
  
  Volume: 20 Issue: 4 Pages: 375-382
- DOI
  10.21873/cgp.20389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K25237
[Journal Article] Development of novel small antitumor compounds inhibiting PD-1/PD-L1 binding2022
- Author(s)
  Akiyama Yasuto, Yamaguchi Ken, et al.
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 11 Pages: 5233-5247
- DOI
  10.21873/anticanres.16030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07649
[Journal Article] Tumor cell enrichment by tissue suspension enables detection of mutations with low variant allele frequency and estimation of germline mutations2022
- Author(s)
  Hatakeyama K, Akiyama Y, et al.
- Journal Title
  
  Sci Rep
  
  Volume: 12 Issue: 1 Pages: 2953-2953
- DOI
  10.1038/s41598-022-06885-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07649, KAKENHI-PROJECT-22K07315
[Journal Article] Development of an automatic measurement method for CD8 and PD-1 positive T cells using image analysis software2022
- Author(s)
  Miyata H, Akiyama Y, et al.
- Journal Title
  
  Anticancer Res
  
  Volume: 42 Issue: 1 Pages: 419-427
- DOI
  10.21873/anticanres.15500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07649
[Journal Article] Characterization of the immunological status of hypermutated solid tumors in the cancer genome analysis project HOPE2022
- Author(s)
  Akiyama Yasuto, Yamaguchi Ken, et al.
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 7 Pages: 3537-3549
- DOI
  10.21873/anticanres.15840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07649
[Journal Article] Development of two 410-cancer-gene panel tests for solid tumors and liquid biopsy based on genome data of 5,143 Japanese cancer patients2022
- Author(s)
  Shimoda Yuji, Akiyama Yasuto, et al.
- Journal Title
  
  Biomed. Res.
  
  Volume: 43 Issue: 4 Pages: 115-126
- DOI
  10.2220/biomedres.43.115
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2022-08-18
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07649
[Journal Article] Comparison of genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma in Japanese patients using a novel panel for cancer-related drug-metabolizing enzyme genes2022
- Author(s)
  Ohnami Sumiko, Akiyama Yasuto, et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 17928-17928
- DOI
  10.1038/s41598-022-22914-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07649
[Journal Article] Immunological and genetic characterization of patients with head and neck cancer who developed recurrence2022
- Author(s)
  Yasui Kazuaki, Akiyama Yasuto, et al.
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 9 Pages: 4417-4428
- DOI
  10.21873/anticanres.15942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07649
[Journal Article] Molecular classification of gastric cancer predicts survival in patients undergoing radical gastrectomy based on project HOPE2021
- Author(s)
  Furukawa Kenichiro、Hatakeyama Keiichi、Terashima Masanori、Nagashima Takeshi、Urakami Kenichi、Ohshima Keiichi、Notsu Akifumi、Sugino Takashi、Yagi Taisuke、Fujiya Keiichi、Kamiya Satoshi、Hikage Makoto、Tanizawa Yutaka、Bando Etsuro、Kanai Yae、Akiyama Yasuto、Yamaguchi Ken
- Journal Title
  
  Gastric Cancer
  
  Volume: 25 Issue: 1 Pages: 138-148
- DOI
  10.1007/s10120-021-01242-0
- NAID
  40022799797
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02705, KAKENHI-PROJECT-20K07649, KAKENHI-PROJECT-21K16476
[Journal Article] BMP4 and PHLDA1 are plausible drug-targetable candidate genes for KRAS G12A-, G12D-, and G12V-driven colorectal cancer2021
- Author(s)
  Ohnami S, Maruyama K, et. al.
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 476 Issue: 9 Pages: 3469-3482
- DOI
  10.1007/s11010-021-04172-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07957, KAKENHI-PROJECT-20K07649
[Journal Article] Alternative evaluation of an ELISPOT assay using cytokine activity as a novel parameter2021
- Author(s)
  Maeda C, Akiyama Y, et al.
- Journal Title
  
  Anticancer Res
  
  Volume: 41 Issue: 8 Pages: 3825-3831
- DOI
  10.21873/anticanres.15175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07649
[Journal Article] EMID1, a multifunctional molecule identified in a murine model for the invasion independent metastasis pathway2021
- Author(s)
  Kawata T, Akiyama Y, et al.
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 16372-16372
- DOI
  10.1038/s41598-021-96006-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07649
[Journal Article] JCGA: the Japanese version of the cancer genome atlas and its contribution to the interpretation of gene alterations detected in clinical cancer genome sequencing2021
- Author(s)
  Serizawa M, Akiyama Y, et al.
- Journal Title
  
  Hum Genome Var
  
  Volume: 8 Issue: 1 Pages: 38-38
- DOI
  10.1038/s41439-021-00170-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07649
[Journal Article] MAGEA10 expression is a predictive marker of early hepatic recurrence after curative gastrectomy for gastric and gastroesophageal junction cancer2021
- Author(s)
  Fujiya K, Akiyama Y, et al.
- Journal Title
  
  Gastric cancer
  
  Volume: 24 Issue: 2 Pages: 341-351
- DOI
  10.1007/s10120-020-01123-y
- NAID
  40022501528
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07649
[Journal Article] Identification of tumor microenvironment-associated immunological genes as potent prognostic markers in the cancer genome analysis project HOPE2021
- Author(s)
  Kondou R, Akiyama Y, et al.
- Journal Title
  
  Mol Clin Oncol
  
  Volume: 15 Issue: 5 Pages: 232-232
- DOI
  10.3892/mco.2021.2395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07649
[Journal Article] Alpha-type-1 polarized dendritic cell-based vaccination in newly diagnosed high-grade glioma: A phase II clinical trial2020
- Author(s)
  Mitsuya K, Akiyama Y, et al.
- Journal Title
  
  Anticancer Res
  
  Volume: 40 Issue: 11 Pages: 6473-6484
- DOI
  10.21873/anticanres.14669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07649, KAKENHI-PROJECT-18K07315
[Journal Article] Japanese version of The Cancer Genome Atlas, JCGA, established using fresh frozen tumors obtained from 5143 cancer patients.2020
- Author(s)
  Nagashima T, Yamaguchi K, Terashima M, et al.
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 2 Pages: 687-699
- DOI
  10.1111/cas.14290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-18K07343, KAKENHI-PROJECT-18K07957
[Journal Article] Characterization of tumors with ultralow tumor mutational burden in Japanese cancer patients2020
- Author(s)
  Hatakeyama K, Akiyama Y, et al.
- Journal Title
  
  Cancer Sci
  
  Volume: 111 Issue: 10 Pages: 3893-3901
- DOI
  10.1111/cas.14572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07649, KAKENHI-PROJECT-18K07315
[Journal Article] Analysis of single nucleotide-mutated single-cancer cells using the combined technologies of single-cell microarray chips and peptide nucleic acid-DNA probes2020
- Author(s)
  Shigeto H, Akiyama Y et al.
- Journal Title
  
  Micromachines
  
  Volume: 11 Issue: 7 Pages: 628-628
- DOI
  10.3390/mi11070628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07649, KAKENHI-PROJECT-18K15299
[Journal Article] Assessment of associations between clinical and immune microenvironmental factors and tumor mutation burden in resected nonsmall cell lung cancer by applying machine learning to whole-slide images.2020
- Author(s)
  Ono A, Terada Y, Kawata T, Serizawa M, Isaka M, Kawabata T, Imai T, Mori K, Muramatsu K, Hayashi I, Kenmotsu H, Ohshima K, Urakami K, Nagashima T, Kusuhara M, Akiyama Y, Sugino T, Ohde Y, Yamaguchi K, Takahashi T.
- Journal Title
  
  Cancer Med.
  
  Volume: - Issue: 13 Pages: 4864-4875
- DOI
  10.1002/cam4.3107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07792, KAKENHI-PROJECT-17K07209
[Journal Article] Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse2019
- Author(s)
  Ashizawa T, Iizuka A, Tanaka E, Kondou R, Miyata H, Maeda C, Sugino T, Yamaguchi K, Ando T, Ishikawa Y, Ito M, Akiyama Y.
- Journal Title
  
  Biomed. Res.
  
  Volume: 40 Issue: 6 Pages: 243-250
- DOI
  10.2220/biomedres.40.243
- NAID
  130007761178
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2019-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-17K07209
[Journal Article] Driver gene alterations and activated signaling pathways toward malignant progression of gastrointestinal stromal tumors.2019
- Author(s)
  Ohshima K, Fujiya K, Nagashima T, Ohnami S, Hatakeyama K, Urakami K, Naruoka A, Watanabe Y, Moromizato S, Shimoda Y, Ohnami S, Serizawa M, Akiyama Y, Kusuhara M, Mochizuki T, Sugino T, Shiomi A, Tsubosa Y, Uesaka K, Terashima M, Yamaguchi K.
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 12 Pages: 3821-3833
- DOI
  10.1111/cas.14202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-17K07209
[Journal Article] Imaging analysis of EGFR mutated cancer cells using peptide nucleic acid (PNA)?DNA probes2019
- Author(s)
  Shigeto Hajime、Ohtsuki Takashi、Iizuka Akira、Akiyama Yasuto、Yamamura Shohei
- Journal Title
  
  The Analyst
  
  Volume: 144 Issue: 15 Pages: 4613-4621
- DOI
  10.1039/c9an00725c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15299, KAKENHI-PROJECT-17K07209
[Journal Article] Identification of a neoantigen epitope in a melanoma patient with good response to anti-PD-1 antibody therapy2019
- Author(s)
  Nonomura C, Otsuka M, Kondou R, Iizuka A, Miyata H, Ashizawa T, Sakura N, Yoshikawa S, Kiyohara Y, Ohshima K, Urakami K, Nagashima T, Ohnami S, Kusuhara M, Mitsuya K, Hayashi N, Nakasu Y, Mochizuki T, Yamaguchi K, Akiyama Y
- Journal Title
  
  Immunol Lett
  
  Volume: 208 Pages: 52-59
- DOI
  10.1016/j.imlet.2019.02.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-17K07209
[Journal Article] A T-cell-engaging B7-H4/CD3-bispecific Fab-scFv Antibody Targets Human Breast Cancer2019
- Author(s)
  Iizuka Akira、Nonomura Chizu、Ashizawa Tadashi、Kondou Ryota、Ohshima Keiichi、Sugino Takashi、Mitsuya Koichi、Hayashi Nakamasa、Nakasu Yoko、Maruyama Kouji、Yamaguchi Ken、Akiyama Yasuto
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 25 Issue: 9 Pages: 2925-2934
- DOI
  10.1158/1078-0432.ccr-17-3123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07235, KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-17K07209
[Journal Article] Mutational burden and signatures in 4000 Japanese cancers provide insights into tumorigenesis and response to therapy2019
- Author(s)
  Hatakeyama K, Akiyama Y
- Journal Title
  
  Cancer Sci
  
  Volume: 110 Issue: 8 Pages: 2620-2628
- DOI
  10.1111/cas.14087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07209
[Journal Article] Impact of combination therapy with anti-PD-1 blockade and a STAT3 inhibitor on the tumor-infiltrating lymphocyte status.2019
- Author(s)
  Ashizawa T, Iizuka A, Maeda C, Tanaka E, Kondou R, Miyata H, Sugino T, Kawata T, Deguchi S, Mitsuya K, Hayashi N, Asai A, Ito M, Yamaguchi K, Akiyama Y.
- Journal Title
  
  Immunol Lett.
  
  Volume: 216 Pages: 43-50
- DOI
  10.1016/j.imlet.2019.10.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-18H02559, KAKENHI-PROJECT-17K07209
[Journal Article] Classification of tumor microenvironment immune types based on immune response-associated gene expression2019
- Author(s)
  Kondou R, Iizuka A, Nonomura C, Miyata H, Ashizawa T, Nagashima T, Ohshima K, Urakami K, Kusuhara M, Yamaguchi K, Akiyama Y
- Journal Title
  
  Int J Oncol
  
  Volume: 54 Pages: 219-228
- DOI
  10.3892/ijo.2018.4617
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-18K07315
[Journal Article] Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations2018
- Author(s)
  Hatakeyama K, Ohshima K, Nagashima T, Ohnami S, Ohnami S, Serizawa M, Shimoda Y, Maruyama K, Akiyama Y, Urakami K, Kusuhara M, Mochizuki T, Yamaguchi K
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 8700-8700
- DOI
  10.1038/s41598-018-26967-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07209
[Journal Article] <b>Tumor mutational burden analysis of 2,000 Japanese cancer genomes using whole exome and targeted gene panel </b><b>sequencing </b>2018
- Author(s)
  Hatakeyama K, Nagashima T, Urakami K, Ohshima K, Serizawa M, Ohnami S, Shimoda Y, Ohnami S, Maruyama K, Naruoka A, Akiyama Y, Kusuhara M, Mochizuki T, Yamaguchi K
- Journal Title
  
  Biomed. Res.
  
  Volume: 39 Issue: 3 Pages: 159-167
- DOI
  10.2220/biomedres.39.159
- NAID
  130007396436
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2018-06-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07209
[Journal Article] Changes in programmed death ligand 1 expression in non-small cell lung cancer patients who received anticancer treatments2018
- Author(s)
  Omori S, Kenmotsu H, Abe M, Watanabe R, Sugino T, Kobayashi H, Nakashima K, Wakuda K, Ono A, TairaT, Naito T, Murakami H, Ohde Y, Endo M, Akiyama Y, Nakajima T, Takahashi T
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 23 Issue: 6 Pages: 1052-1059
- DOI
  10.1007/s10147-018-1305-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07209
[Journal Article] Sutureless microvascular anastomosis assisted by an expandable shape-memory alloy stent2017
- Author(s)
  Saegusa Noriko、Sarukawa Shunji、Ohta Kunihiro、Takamatsu Kensuke、Watanabe Mitsuhiro、Sugino Takashi、Nakagawa Masahiro、Akiyama Yasuto、Kusuhara Masatoshi、Kishi Kazuo、Inoue Keita
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 7 Pages: e0181520-e0181520
- DOI
  10.1371/journal.pone.0181520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08727, KAKENHI-PROJECT-17K07209
[Journal Article] Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors.2017
- Author(s)
  Ohshima K, Hatakeyama K, Nagashima T, Watanabe Y, Kanto K, Doi Y, Ide T, Shimoda Y, Tanabe T, Ohnami S, Ohnami S, Serizawa M, Maruyama K, Akiyama Y, Urakami K, Kusuhara M, Mochizuki T, Yamaguchi K
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 641-641
- DOI
  10.1038/s41598-017-00219-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430150, KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-15K06893
[Journal Article] Immune response-associated gene profiling in Japanese melanoma patients using multi-omics analysis2017
- Author(s)
  Akiyama Yasuto、Kiyohara Yoshio、Yoshikawa Shusuke、Otsuka Masaki、Kondou Ryota、Nonomura Chizu、Miyata Haruo、Iizuka Akira、Ashizawa Tadashi、Ohshima Keiichi、Urakami Kenichi、Nagashima Takeshi、Kusuhara Masatoshi、Sugino Takashi、Yamaguchi Ken
- Journal Title
  
  Oncology Reports
  
  Volume: 39 Pages: 1125-1131
- DOI
  10.3892/or.2017.6173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08727, KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-18K07315
[Journal Article] Antitumor Effect of Programmed Death-1 (PD-1) Blockade in Humanized the NOG-MHC Double Knockout Mouse.2017
- Author(s)
  Ashizawa T, Iizuka A, Nonomura C, Kondou R, Maeda C, Miyata H, Sugino T, Mitsuya K, Hayashi N, Nakasu Y, Maruyama K, Yamaguchi K, Katano I, Ito M, Akiyama Y.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 23(1) Issue: 1 Pages: 149-158
- DOI
  10.1158/1078-0432.ccr-16-0122
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430178, KAKENHI-PROJECT-16K08727, KAKENHI-PROJECT-16K18405
[Journal Article] The anti-tumor activity of the STAT3 inhibitor STX-0119 occurs via promotion of tumor-infiltrating lymphocyte accumulation in temozolomide-resistant glioblastoma cell line2017
- Author(s)
  Akiyama Yasuto、Nonomura Chizu、Ashizawa Tadashi、Iizuka Akira、Kondou Ryota、Miyata Haruo、Sugino Takashi、Mitsuya Koichi、Hayashi Nakamasa、Nakasu Yoko、Asai Akira、Ito Mamoru、Kiyohara Yoshio、Yamaguchi Ken
- Journal Title
  
  Immunology Letters
  
  Volume: 190 Pages: 20-25
- DOI
  10.1016/j.imlet.2017.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08727, KAKENHI-PROJECT-17K07209
[Journal Article] In situ delivery and production system of trastuzumab scFv with Bifidobacterium2017
- Author(s)
  Kikuchi Takeshi、Shimizu Hitomi、Akiyama Yasuto、Taniguchi Shun'ichiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 493 Issue: 1 Pages: 306-312
- DOI
  10.1016/j.bbrc.2017.09.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-15K08022
[Journal Article] Effect of STAT3 inhibition on the metabolic switch in a highly STAT3-activated lymphoma cell line2015
- Author(s)
  Akiyama Y
- Journal Title
  
  Cancer Genomics Proteomics
  
  Volume: 12(3) Pages: 133-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430166
[Journal Article] Immunologically augmented skin flap as a novel dendritic cell vaccine against head and neck cancer in a rat model.2015
- Author(s)
  Inoue K, Saegusa N, Omiya M, Ashizawa T, Miyata H, Komiyama M, Iizuka A, Kume A, Sugino T, Yamaguchi K, Kiyohara Y, Nakagawa M, Akiyama Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 106 (2) Issue: 2 Pages: 143-150
- DOI
  10.1111/cas.12586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-24592725, KAKENHI-PROJECT-25430166, KAKENHI-PROJECT-26430178
[Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of temozolomide-resistant glioblastoma cell line2014
- Author(s)
  Ashizawa T, Akiyama Y, Miyata H, Iizuka A, Komiyama M, Kume A, Omiya M, Sugino T, Asai A, Hayashi N, Mitsuya K, Nakasu Y, Yamaguchi K
- Journal Title
  
  Int. J. Oncology
  
  Volume: 45 Pages: 411-418
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24501362
[Journal Article] Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients2014
- Author(s)
  Akiyama Y et al.
- Journal Title
  
  Oncol Rep
  
  Volume: 31 Pages: 1683-1690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430166
[Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of a temozolomide-resistant glioblastoma cell line2014
- Author(s)
  Ashizawa T, Akiyama Y, Miyata H, Iizuka A, Komiyama M, Kume A, Omiya M, Sugino T, Asai A, Hayashi N, Mitsuya K, Nakasu Y, Yamaguchi K
- Journal Title
  
  Int J Oncol.
  
  Volume: 411-8 Issue: 1 Pages: 411-418
- DOI
  10.3892/ijo.2014.2439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510281, KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-25430166, KAKENHI-PROJECT-26430166
[Journal Article] Anti-vascular endothelial growth factor receptor (VEGFR) 2 autoantibody identification in glioblastoma patient using single B cell-based antibody gene cloning2014
- Author(s)
  Iizuka A, Akiyama Y et al.
- Journal Title
  
  Immunol Lett
  
  Volume: 159 Issue: 1-2 Pages: 15-22
- DOI
  10.1016/j.imlet.2014.02.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430166
[Journal Article] YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell line.2014
- Author(s)
  Akiyama Y, Ashizawa T, Komiyama M, Miyata H, Oshita C, Omiya M, Iizuka A, Kume A, Sugino T, Hayashi N, Mitsuya K, Nakasu Y, Yamaguchi K.
- Journal Title
  
  Oncol Rep
  
  Volume: 32 (1) Issue: 1 Pages: 159-166
- DOI
  10.3892/or.2014.3195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-24501362, KAKENHI-PROJECT-25430166
[Journal Article] Anti-vascular endothelial growth factor receptor (VEGFR) 2 autoantibody identification in glioblastoma patient using single B cell-based antibody gene cloning2014
- Author(s)
  Iizuka A, Komiyama M, Oshita C, Kume A, Ashizawa T, Mitsuya K, Hayashi N, Nakasu Y, Yamaguchi K and Akiyama Y
- Journal Title
  
  Immunol Lett.
  
  Volume: 159 Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501362
[Journal Article] Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients.2014
- Author(s)
  Akiyama Y, Komiyama M, Miyata H, Yagoto M, Ashizawa T, Iizuka A, Oshita C, Kume A, Nogami M, Ito I, Watanabe R, Sugino T, Mitsuya K, Hayashi N, Nakasu Y, Yamaguchi K.
- Journal Title
  
  Oncol Rep.
  
  Volume: 31 Issue: 4 Pages: 1683-1690
- DOI
  10.3892/or.2014.3049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-24501362, KAKENHI-PROJECT-26430178
[Journal Article] The identification of affinity peptide ligands specific to the variable region of human antibodies2014
- Author(s)
  Akiyama Y
- Journal Title
  
  Biomed Res
  
  Volume: 35 Pages: 105-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430166
[Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proligeration of cancer stem cells derived from glioblastoma patients2013
- Author(s)
  Ashizawa T, Akiyama Y et al.
- Journal Title
  
  Int J Oncol
  
  Volume: 43 Pages: 219-227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25430166
[Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma2013
- Author(s)
  Tadashi Ashizawa, Haruo Miyata, Akira Iizuka, Masaru Komiyama, Chie Oshita, Akiko Kume, Masahiro Nogami, Mika Yagoto, Ichiro Ito, Takuma Oishi, Reiko Watanabe, Koichi Mitsuya, Kenji Matsuno, Toshio Furuya, Tadashi Okawara, Masami Otsuka, Naohisa Ogo, Akira Asai, Yoko Nakasu, Ken Yamaguchi Yasuto Akiyama
- Journal Title
  
  International Journal of Oncology
  
  Volume: 43 Issue: 1 Pages: 219-227
- DOI
  10.3892/ijo.2013.1916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390028, KAKENHI-PROJECT-23510281, KAKENHI-PROJECT-24501362, KAKENHI-PROJECT-24659048
[Journal Article] Dendritic cell-based vaccination in metastatic melanoma patients: phase II clinical trial2012
- Author(s)
  Oshita C, Takikawa M, Kume A, Miyata H, Ashizawa T, Iizuka A, Kiyohara Y, Yoshikawa S, Tanosaki R, Yamazaki N, Yamamoto A, Takesako K, Yamaguchi K and Akiyama Y
- Journal Title
  
  Oncol Rep
  
  Volume: 28 Issue: 4 Pages: 1131-8
- DOI
  10.3892/or.2012.1956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501362
[Journal Article] Identification of novel MAGE-A6- and MAGE-A12-derived HLA-A24-restricted cytotoxic T lymphocyte epitopes using an in silico peptide-docking assay2012
- Author(s)
  Akiyama Y, Komiyama M, Nakamura Y, Iizuka A, Oshita C, Kume A, Nogami M, Miyata H, Ashizawa T, Yoshikawa S, Kiyohara Y and Yamaguchi K
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 61 Issue: 12 Pages: 2311-9
- DOI
  10.1007/s00262-012-1298-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501362
[Journal Article] α-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial.2012
- Author(s)
  Akiyama Y, Oshita C, Kume A, Iizuka A, Miyata H, Komiyama M, Ashizawa T, Yagoto M, Abe Y, Mitsuya K, Watanabe R, Sugino T, Yamaguchi K, Nakasu Y.
- Journal Title
  
  BMC Cancer
  
  Volume: 27;12 Issue: 1 Pages: 623-623
- DOI
  10.1186/1471-2407-12-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-24501362
[Journal Article] Identification of cytomegalovirus(CMV) pp65 antigenspecific human monoclonal antibodies using single B cell-based antibody gene cloning from melanoma patients2011
- Author(s)
  Iizuka A, Komiyama M, Tai S, Oshita C, Kurusu A, Kume A, Ozawa K, Nakamura Y, Ashizawa T, Yamamoto A, Yamazaki N, Yoshikawa S, Kiyohara Y, Yamaguchi K, Akiyama Y
- Journal Title
  
  Immunol Lett
  
  Volume: 135 Pages: 64-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] Antitumor activity of a novel small molecule STAT3 inhibitor2011
- Author(s)
  Ashizawa T, Miyata H, Ishii H, Oshita C, Matsuno K, Masuda Y, Furuya T, Okawara T, Otsuka M, Ogo N, Asai A, and Akiyama Y
- Journal Title
  
  Int J Oncol
  
  Volume: 38(5) Pages: 1245-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] Analysis of HLA-A24-restricted peptides of Carcinogenic embryonic antigen(CEA) using a novel structure-based peptide-HLA docking algorithm2011
- Author(s)
  Nakamura Y, Oshita C, Iizuka A, Ashizawa T, Saito S, Yamaguchi S, Kondo H, Yamaguchi K, Akiyama Y
- Journal Title
  
  Cancer Sci
  
  Volume: 102(4) Pages: 690-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] Identification of melanoma antigens using SERPA(serological proteome approach)2010
- Author(s)
  Suzuki A, Iizuka A, Komiyama M, Takikawa M, Kume A, Tai S, Ohshita C, Kurusu A, Nakamura Y, Yamamoto A, Yamazaki N, Yoshikawa S, Kiyohara Y, Akiyama Y
- Journal Title
  
  Cancer Genomics and Proteomics
  
  Volume: 7(1) Pages: 17-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] TCR-βRepertoire Analysis of Antigen-specific Single T Cells Using a High-density Microcavity Array2010
- Author(s)
  Arakaki A, Ooya K, Akiyama Y, Hosokawa M, Komiyama M, Tai S, Iizuka A, Yamaguchi K, Matsunaga T
- Journal Title
  
  Biotechnol Bioeng
  
  Volume: 106(2) Pages: 311-318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] S-trityl-L-cysteine derivative indices caspase-independent cell death in K562 human chronic myeloid leukemia cell line2010
- Author(s)
  Shimizu M, Ishii H, Ogo N, Unno Y, Matsuno K, Sawada J, Akiyama Y, Asai A
- Journal Title
  
  Cancer Lett
  
  Volume: 298(1) Pages: 99-106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] Identification of a new series of STAT3 inhibitors by virtual screening2010
- Author(s)
  Matsuno K, Masuda Y, Uehara Y, Sato H, Muroya A, Takahashi O, Yokotagawa T, Furuya T, Okawara T, Otsuka M, Ogo N, Ashizawa T, Oshita C, Tai S, Ishii H, Akiyama Y, Asai A
- Journal Title
  
  ACS Med Chem Lett
  
  Volume: 1(8) Pages: 371-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] CIG-DB : the database for human or mouse immunoglobulin and T cell receptor genes available for cancer studies2010
- Author(s)
  Nakamura Y, Komiyama T, Furue M, Gojobori T, Akiyama Y
- Journal Title
  
  BMC Bioinformatics
  
  Volume: 11 Pages: 398-398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] Disrupting actin filaments promotes efficient transfection of a leukemic cell line using cell adhesive protein-embedded carbonate apatite particles2009
- Author(s)
  Kutsuzawa K, Tada S, Hossain S, Fukuda K, Maruyama K, Akiyama Y, Akaike T, Chowdhury EH
- Journal Title
  
  Anal Biochem
  
  Volume: 388 Pages: 164-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] Characterization of a MAGE-1-derived HLA-A24 Epitope-specific CTL Line from a Japanese Metastatic Melanoma Patient2009
- Author(s)
  Akiyama Y et al.
- Journal Title
  
  Anticancer Res 29
  
  Pages: 647-656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021050
[Journal Article] Magnetic separation of melanoma-specific cytotoxic T lymphocytes from a vaccinated melanoma patient using MHC/peptide complex-conjugated bacterial magnetic particles2009
- Author(s)
  Takahashi M, Akiyama Y et al.
- Journal Title
  
  Bioconjugate Chem 20
  
  Pages: 304-309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021050
[Journal Article] 一細胞分離技術を用いたがん特異的免疫細胞の遺伝子スクリーニング法の開発2009
- Author(s)
  秋山靖人
- Journal Title
  
  応用物理
  
  Volume: 78(12) Pages: 1123-1127
- NAID
  10026198589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] Identification of melanoma-specific serological markers using proteomic analyses2009
- Author(s)
  Takikawa M, Akiyama Y, Ashizawa T, Yamamoto A, Yamazaki N, Kiyohara Y, Oku N, Yamaguchi K
- Journal Title
  
  Proteomics-CA
  
  Pages: 552-562
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] Disrupting actin filaments ptomotes efficient transfection of a leukemic cell line using cell adhesive protein-embedded carbonate apatite particles2009
- Author(s)
  Kutsuzawa K, Akiyama Y et al.
- Journal Title
  
  Anal Biochem (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021050
[Journal Article] Characterization of cytomegalovirus(CMV) pp65-HLA-A24 peptide-specific CTL lines from metastatic melanoma patients2009
- Author(s)
  Akiyama Y, Tai S, Komiyama M, Takikawa M, Ohshita C, Yamamoto A, Yamazaki N, Kiyohara Y
- Journal Title
  
  Oncol Rep
  
  Volume: 22(1) Pages: 185-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591451
[Journal Article] Efficient transfection of mouse embryonic stem cells with cell-adhesive protein-embedded inorganic nanocarrier2008
- Author(s)
  Kutsuzawa K, Akiyama Y et al.
- Journal Title
  
  Anal Biochem 372
  
  Pages: 122-124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021050
[Journal Article] Changes in the expression of CDユ06,osteogenic genes,and transcriptionfactors involved in the osteogenic differentiation of human bone marrormesenchymal stem cells2008
- Author(s)
  Liu F, Akiyama Y, et. al.
- Journal Title
  
  J Bone Miner Metab 26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021050
[Journal Article] Preparation of human immune T Cells containing iron-oxide nanoparticles for magnetically mediated immunotherapy2008
- Author(s)
  Iida H, Akiyama Y et al.
- Journal Title
  
  Biotecnol Bioeng 101(6):1123-1128,2008 101
  
  Pages: 1123-1128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021050
[Journal Article] Novel approach to the characterization of melanoma associated-peptide-specific CTL lines from Japanese metastatic melanoma patients2008
- Author(s)
  Akiyama Y et al.
- Journal Title
  
  Int J Oncol 33
  
  Pages: 433-442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021050
[Journal Article] Protein kinase C activation enhances transfection efficacy of cell-adhesive protein-anchored carbonate apatite nanocrystals2007
- Author(s)
  Kutsuzawa K, Akiyama Y, et. al.
- Journal Title
  
  Anal Biochem 371
  
  Pages: 116-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19021050
[Patent] 国際特許、優先権2017
- Inventor(s)
  AKIYAMA Yasuto; IIZUKA Akira
- Industrial Property Rights Holder
  Shizuoka prefecture
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K07235
[Patent] 抗蛍光色素モノクローナル抗体2013
- Inventor(s)
  秋山靖人、飯塚　明
- Industrial Property Rights Holder
  静岡県
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-248159
- Filing Date
  2013-11-29
- Data Source
  KAKENHI-PROJECT-25430166
[Patent] ELISA法を用いたヒト血清中の抗原特異的なIgG抗体力価測定の標準化法2009
- Inventor(s)
  秋山靖人,飯塚明
- Industrial Property Rights Holder
  静岡県
- Filing Date
  2009-03-31
- Data Source
  KAKENHI-PROJECT-19021050
[Patent] プロテオミクス解析を用いたメラノーママーカーの同定2008
- Inventor(s)
  秋山靖人,瀧川雅子
- Industrial Property Rights Holder
  静岡県
- Industrial Property Number
  2008-149728
- Filing Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-19021050
[Patent] T細胞レセプターβ鎖遺伝子およびα鎖遺伝子2008
- Inventor(s)
  秋山靖人丸山宏二
- Industrial Property Rights Holder
  静岡県
- Industrial Property Number
  2008-008755
- Filing Date
  2008-01-18
- Data Source
  KAKENHI-PROJECT-19021050
[Patent] プロテオミクス解析を用いたメラノーママーカーの同定2008
- Inventor(s)
  秋山靖人、瀧川雅子
- Industrial Property Rights Holder
  秋山靖人、瀧川雅子
- Industrial Property Number
  2008-149728
- Filing Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-21591451
[Patent] 1細胞レベルでのT細胞抗原レセプター遺伝子の解析・同定方法2007
- Inventor(s)
  秋山靖人松永是新垣篤史
- Industrial Property Rights Holder
  静岡県
- Industrial Property Number
  2007-176683
- Filing Date
  2007-07-04
- Data Source
  KAKENHI-PROJECT-19021050
[Patent] 1細胞レベルでめ抗体遺伝子の解析・同定方法2007
- Inventor(s)
  秋山靖人
- Industrial Property Rights Holder
  静岡県
- Industrial Property Number
  2007-147525
- Filing Date
  2007-06-01
- Data Source
  KAKENHI-PROJECT-19021050
[Patent] ヒトー本鎖抗体遺伝子断片の効率的な新規調整法2007
- Inventor(s)
  秋山靖人丸山宏二
- Industrial Property Rights Holder
  静岡県
- Industrial Property Number
  2007-092968
- Filing Date
  2007-03-30
- Data Source
  KAKENHI-PROJECT-19021050
[Patent] T細胞レセプターβ鎖遺伝子2007
- Inventor(s)
  秋山靖人, 丸山宏二
- Industrial Property Rights Holder
  静岡県
- Industrial Property Number
  2007-077568
- Filing Date
  2007-03-23
- Data Source
  KAKENHI-PROJECT-18038049
[Presentation] Anorectal transplantation: the first long-term success in a canine model2024
- Author(s)
  Jun ARAKI, Yuji NISHIZAWA, Naoki FUJITA, Kaori FUKUSHIGE, Yasuto AKIYAMA, Kana SANO, Flavio GALVAO, Munekazu NAITO
- Organizer
  12th ERC Meeting & 34th EURAPS Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27759
[Presentation] Anorectal Transplantation: International Collaboration Research for Stoma Patients2024
- Author(s)
  Jun ARAKI, Yuji NISHIZAWA, Naoki FUJITA, Kaori FUKUSHIGE, Yasuto AKIYAMA, Kana SANO, Flavio GALVAO, Munekazu NAITO
- Organizer
  16th Congress of the European Federation of Societies for Microsurgery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27759
[Presentation] 1細胞トラップおよび培養のための細胞マイクロアレイチップ形状の最適化2023
- Author(s)
  上野秀貴、重藤元、飯塚明、秋山靖人、山村昌平
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-23K25237
[Presentation] ペプチド核酸プローブと１細胞マイクロアレイチップの融合による遺伝子変異がん細胞のイメージング検出法の開発2023
- Author(s)
  重藤元、北松瑞生、大槻高史、飯塚明、秋山靖人、山村昌平
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-23K25237
[Presentation] 肺がん細胞株における新規核酸プローブを用いた変異EGFR遺伝子の検出2022
- Author(s)
  宮田　治男、秋山　靖人、他
- Organizer
  第81回日本癌学会学術総会～横浜
- Data Source
  KAKENHI-PROJECT-20K07649
[Presentation] HLA-ABC単一アレルノックイン、TAP2-KO-TISI株を用いたがん遺伝子変異由来標的エピトープのインビトロ検証2022
- Author(s)
  飯塚　明、秋山　靖人、他
- Organizer
  第81回日本癌学会学術総会～横浜
- Data Source
  KAKENHI-PROJECT-20K07649
[Presentation] 2段型マイクロチャンバーアレイチップを用いた1細胞培養技術2022
- Author(s)
  上野秀貴、重藤元、飯塚明、秋山靖人、山村昌平
- Organizer
  第45回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-23K25237
[Presentation] Development of automatic measurement method for CD8 and PD-1 positive T cells using image analysis software2021
- Author(s)
  Miyata H, Akiyama Y, et al.
- Organizer
  The 80th Annual meeting of the Japan Cancer Association, Hirosima
- Data Source
  KAKENHI-PROJECT-20K07649
[Presentation] Association of immune types classification based on tumor microenvironment with patients' prognosis in project HOPE2021
- Author(s)
  Kondou R, Akiyama Y, et al.
- Organizer
  The 80th Annual meeting of the Japan Cancer Association, Yokohama
- Data Source
  KAKENHI-PROJECT-20K07649
[Presentation] Evaluation of ELISPOT assay using cytokine activity parameter2021
- Author(s)
  Maeda C, Akiyama Y, et al.
- Organizer
  The 80th Annual meeting of the Japan Cancer Association, Yokohama
- Data Source
  KAKENHI-PROJECT-20K07649
[Presentation] Development of tumor-infiltrating lymphocytes (TIL)-measuring method using image analysis software2020
- Author(s)
  Miyata H, Akiyama Y et al.
- Organizer
  The 79th Annual meeting of the Japan Cancer Association, Hirosima
- Data Source
  KAKENHI-PROJECT-20K07649
[Presentation] Association of immune types classification based on tumor microenvironment with patients' prognosis in project HOPE2020
- Author(s)
  Kondou R, Akiyama Y, et al.
- Organizer
  The 79th Annual meeting of the Japan Cancer Association, Hirosima
- Data Source
  KAKENHI-PROJECT-20K07649
[Presentation] Alpha-type-1 polarized dendritic cell-based vaccination in newly diagnosed high-grade glioma: A phase II clinical trial2020
- Author(s)
  Maeda C, Akiyama Y, et al.
- Organizer
  The 79th Annual meeting of the Japan Cancer Association, Hirosima
- Data Source
  KAKENHI-PROJECT-20K07649
[Presentation] 抗PD-1抗体療法が奏功したメラノーマ症例におけるネオアンチゲンの同定2019
- Author(s)
  秋山靖人
- Organizer
  第78回癌学会学術総会（京都）
- Data Source
  KAKENHI-PROJECT-17K07209
[Presentation] T-cell-engaging B7-H4/CD3 bispecific Fab-scFv antibody targeting human breast cancer2018
- Author(s)
  Akira Iizuka, Tadashi Ashizawa, Keiichi Ohshima, Masatoshi Kusuhara, Ken Yamaguchi, Yasuto Akiyama
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K07235
[Presentation] Characterization of hypermutated tumors based on tumor microenvironment immune types classification2018
- Author(s)
  Akiyama　Y, Iizuka A, Nagashima T, Shimoda Y, Tanabe T, Ohnami S, Ohnami S, Ohshima K, Urakami K, Kusuhara M, Mochizuki T, Yamaguchi K
- Organizer
  第77回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-17K07209
[Presentation] Classification of tumor microenvironment immune types based on the immune response-associated gene expression2017
- Author(s)
  Akiyama Y, Iizuka A, Nagashima T, Shimoda Y, Tanabe T, Ohnami S, Ohnami S, Ohshima K, Urakami K, Kusuhara M, Mochizuki T, Yamaguchi K
- Organizer
  第76回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-17K07209
[Presentation] Anti-PD-1 antibody therapy using humanized MHC-dKO NOG mouse2015
- Author(s)
  Tadashi Ashizawa, Akira Iizuka, Kouji Maruyama, Ken Yamaguchi, Yasuto Akiyama
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  Nagoya Congress Center
- Year and Date
  2015-10-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430178
[Presentation] Progect HOPE (High-tech Omics-based Patient Evaluation)-Immunosuppressive gene expression for 1,000 cancer patients2015
- Author(s)
  秋山靖人
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-25430166
[Presentation] プロジェクトHOPE（マルチオーミクス解析を用いたがん患者評価)－グリオブラストーマ細胞株における遺伝子解析2014
- Author(s)
  秋山靖人、小宮山優、長嶋剛史、下田勇次、田邉智絵、大浪澄子、大浪俊平、大島啓一、浦上研一、楠原正俊、望月徹、山口建
- Organizer
  第７３回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26430178
[Presentation] Project HOPE (High-tech Omics-based Patient Evaluation) for cancer clinics-Studies on glioblastoma cell lines2014
- Author(s)
  秋山　靖人
- Organizer
  第73回日本癌学会総会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-25430166
[Presentation] 神経膠芽腫患者由来のがん性幹細胞の増殖に及ぼすSTAT3阻害剤STX-0119の効果2013
- Author(s)
  芦澤　忠、飯塚　明、小宮山　優、浅井章良、山口　建、秋山靖人
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24501362
[Presentation] Effect of the STAT3 inhibitor STX-0119 on the proligeration of cancer stem cells derived from glioblastoma patients2013
- Author(s)
  Ashizawa T, Akiyama Y et al.
- Organizer
  第72回日本癌学会総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-25430166
[Presentation] HLA-ペプチドドッキング解析に基づいた免疫創薬的アプローチ2011
- Author(s)
  秋山靖人
- Organizer
  第20回日本組織適合性学会大会
- Place of Presentation
  ツインメッセ静岡静岡市
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-21591451
[Presentation] Novel approach to the characterization of melanoma associatedpeptide-specific CTL lines from metastatic melanoma patients2011
- Author(s)
  Akiyama Y
- Organizer
  China-Japan Symposium on Cancer Reasearch
- Place of Presentation
  Pattaya Hotel, Shenzhen, China
- Data Source
  KAKENHI-PROJECT-21591451
[Presentation] HLA-ペプチドドッキング解析に基づいた免疫創薬的アポローチ2011
- Author(s)
  秋山靖人
- Organizer
  第20回日本組織適合性学会
- Place of Presentation
  静岡市
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-21591451
[Presentation] Novel approach to the characterization of melanoma-peptide-specific CTL lines from metastatic melanoma patients2011
- Author(s)
  Yasuto Akiyama
- Organizer
  China-Japan symposium on Cancer Research
- Place of Presentation
  Shenzhen, China
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21591451
[Presentation] Development of single cell-based screening method for cancer-specific immune cell-related genes2009
- Author(s)
  秋山靖人他
- Organizer
  International Life Surveyor Symposium
- Place of Presentation
  日立中央研究所、東京
- Year and Date
  2009-01-29
- Data Source
  KAKENHI-PROJECT-19021050
[Presentation] Single cell-based characterization of cancer-specific immuno-biomarker genes2009
- Author(s)
  秋山靖人他
- Organizer
  International Workshop HITS 2009
- Place of Presentation
  東京工大、横浜
- Year and Date
  2009-02-05
- Data Source
  KAKENHI-PROJECT-19021050
[Presentation] Development of single cell-based screening method for cancer-specific immune cell-related genes2008
- Author(s)
  秋山靖人
- Organizer
  Prof. Michael Nobel Symposium
- Place of Presentation
  静岡がんセンター研究所
- Year and Date
  2008-09-24
- Data Source
  KAKENHI-PROJECT-19021050
[Presentation] プロテオミクス解析によるメラノーマ特異的な血清学的マーカーの同定2008
- Author(s)
  瀧川雅子、秋山靖人他
- Organizer
  第67回日本がん学会総会
- Place of Presentation
  名古屋市
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19021050
[Presentation] 1細胞蛍光検出技術を用いたがん特異的免疫細胞の遺伝子スクリーニング法の開発2008
- Author(s)
  秋山靖人他
- Organizer
  文科省特定領域研究班第6回シンポジウム
- Place of Presentation
  大阪大学
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-19021050
[Presentation] 免疫療法の基盤技術の開発と臨床応用への展開2007
- Author(s)
  秋山靖人, 他
- Organizer
  平成19年度都市エリア発展型研究成果発表会
- Place of Presentation
  静岡県沼津市
- Year and Date
  2007-03-04
- Data Source
  KAKENHI-PROJECT-19021050
[Presentation] Development of single cell-based screening method for cancer-specificimmune cell-related genes2007
- Author(s)
  Akiyama Y, Arakaki A, et. al.
- Organizer
  The 2nd international workshop on approaches to single-cell analysis
- Place of Presentation
  早稲田大学(東京)
- Year and Date
  2007-09-06
- Data Source
  KAKENHI-PROJECT-19021050
[Presentation] 1細胞蛍光検出技術を用いたがん特異的免疫細胞の遺伝子スクリーニング法の開発2007
- Author(s)
  秋山靖人, 他
- Organizer
  文科省特定領域研究班領域班シンポジウム
- Place of Presentation
  名古屋大
- Year and Date
  2007-01-31
- Data Source
  KAKENHI-PROJECT-19021050
[Presentation] バイオマーカーとしての生体内免疫応答の解析2007
- Author(s)
  秋山靖人, 他
- Organizer
  東海大学クリニカルバイオメデイカルマスターコースシンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-09-13
- Data Source
  KAKENHI-PROJECT-19021050
[Presentation] 悪性グリオーマ患者より樹立したグリオーマ初代培養細胞株での腫瘍抗原の発現
- Author(s)
  小宮山　優、飯塚　明、芦沢　忠、久米　亜希子、三矢　幸一、中洲　庸子、山口　建、秋山　靖人
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-24501362
[Presentation] テモゾロミド耐性神経膠芽腫細胞に対するSTAT3阻害剤STX-0119のin vitro及びin vivo抗腫瘍効果
- Author(s)
  芦澤　忠、飯塚　明、小宮山　勝、浅井　章良、山口　建、秋山　靖人
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24501362

1. KIYOHARA Yoshio (70205037)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. ANDO Takayuki (40402226)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. INOUE Keita (80618520)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAKAGAWA Masahiro (00285793)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Iizuka Akira (00463183)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. ASHIZAWA Tadashi (10443441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. UDA Hirokazu (20337306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 新垣篤史 (10367154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 小郷尚久 (20501307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 三枝紀子 (10642639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 山村昌平 (50432141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. 重藤元 (60805662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
13. 荒木淳 (00508088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 藤田直己 (10554488)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 福重香 (30805023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 西澤祐吏 (50545001)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 佐野加奈 (90899858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. ASAI Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 金井弥栄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 杉野隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
21. 大島啓一

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
22. 寺島雅典

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 楠原正俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 大浪俊平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 大塚雅巳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 芹澤昌邦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 釼持広知

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 盛啓太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

akiyama yasuto 秋山 靖人

AKIYAMA Yasuto 秋山 靖人

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Development of driver mutation-specific novel neoantigen vaccines based on cancer genome analysisPrincipal Investigator

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Immune response-associated gene expression profiling for biomarker development in hypermutated tumorsPrincipal Investigator

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Development of novel human antibody against malignant glioma-derived stem cellPrincipal Investigator

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Identification of melanoma-specific serum biomarker and its clinical applicationPrincipal Investigator

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1細胞蛍光検出技術を用いた腫瘍内がん特異的免疫細胞の遺伝子スクリーニング法の開発Principal Investigator

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1細胞蛍光検出技術を用いたがん特異的免疫細胞の遺伝子スクリーニング法の開発Principal Investigator

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akiyama yasuto 秋山靖人

AKIYAMA Yasuto 秋山靖人