KIKUCHI Hirotaka 菊地寛高

… Alternative Names

菊地寛高キクチヒロタカ

菊池寛高キクチヒロタカ

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Researcher Number	70234193
External Links
Affiliation (Current)	2022: 明海大学, 歯学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2016: 明海大学, 歯学部, 非常勤講師 2014 – 2015: 明海大学, 歯学部, その他 2010: 明海大学, 歯学部, 講師 2007: 明海大学, 歯学部, 講師 2006: 明海大学, 歯学部, 助手 2002 – 2004: 明海大学, 歯学部, 助手 1993 – 2000: 明海大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Conservative dentistry Except Principal Investigator Morphological basic dentistry / Conservative dentistry
Keywords	Principal Investigator 線毛 / IL-4 / 一酸化窒素 / 破骨細胞形成 / MCP-1 / 骨吸収 / サイトカイン産生 / Porphyromonas gingivalis / transforming growth factor-β / TGF-β … More / マクロライド / 根尖性歯周炎 / 歯内治療 / macrolides / apical periodontitis / endodontics … More Except Principal Investigator P.gingivalis / 線毛 / 歯周疾患 / 遺伝子発現 / 生体材料 / 再生医学 / 歯学 / 歯髄 / PRP / サイトカイン / 骨吸収 / LPS / IL-6 / ODF / OCIF / CD14 / TLR4 / 受動免疫 / 能動免疫 / 歯周組織 / 炎症性サイトカイン / 歯髄幹細胞 / 分化誘導 / 硬組織再生 / ヒアルロン酸 / CD44 / シグナル伝達系 / ヒト歯髄幹細胞 / 象牙芽細胞への分化 / シグナル伝達経路 / 石灰化誘導 / 象牙芽細胞 / 骨吸収作用 / 炎症 / ワクチン / P..gingivalis / Fimbriae / Bone resorption / Inflammation / Vaccination / 成人性歯周病 / 遺伝子組換え / マクロファージ / 活性部位 / レセプター / 遺伝子組み換え / Fibronectin / adult periodontitis / fimbriae / recombination / macrophages / active domain / gene expression / Cytokine / bone resorption / IL-1β / TNFα / ST-2 / 破骨細胞形成 Less

Analysis of PI3-kinase/Akt signaling on the osteogenesis of dental pulp stem cells in human.
- Principal Investigator
  
  KATAYAMA Tadashi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Meikai University
The analysis and significance of the autoderived-growthfactor as a stimulator of the proliferation and the differentiation of human dental pulp stem cells
- Principal Investigator
  
  KATAYAMA Tadashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Meikai University
The improvement PRP treatment was investigate the applied likelihood to endodontic treatment
- Principal Investigator
  
  SUDA Tomoyo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Meikai University
Inhibitory Effects of Antimicrobial Agent Macrolides on LPS-induced periodontal destruction in periapical region.Principal Investigator
- Principal Investigator
  
  KIKUCHI Hirotaka
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Conservative dentistry
- Research Institution
  Meikai University
Identification and application of functional active domain of P.gingivalis fimbriae
- Principal Investigator
  
  HANAZAWA Shigemasa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Morphological basic dentistry
- Research Institution
  KYUSHU UNIVERSITY
  Meikai University
Regulatory mechanism of expression of ODF and OCIF genes in P.gingivalis LPS-induced bone resorption.
- Principal Investigator
  
  AMANO Shigeru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
P．gingivalis線毛免疫による歯周組織破壊に関する防御機構の解析
- Principal Investigator
  
  KITANO Shigeo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
菌体構成成分による一酸化窒素産生誘導とTGF-βによる抑制作用Principal Investigator
- Principal Investigator
  
  菊地寛高
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
P.gingivalis線毛による一酸化窒素産生誘導とIL-4による抑制作用Principal Investigator
- Principal Investigator
  
  菊地寛高
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
P. gingivaris線毛によるリン酸化蛋白質の発現とIL-4による抑制作用Principal Investigator
- Principal Investigator
  
  菊地寛高
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
モノサイト走化性活性化因子MCP-1による破骨細胞形成制御機構の解析Principal Investigator
- Principal Investigator
  
  菊池寛高
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
P.gingivalis線毛の成人型歯周疾患ワクチンへの応用に関する基礎的研究
- Principal Investigator
  
  KITANO Shigeo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University

All 2016 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation

[Journal Article] Hyaluronan induces odontoblastic differentiation of dental pulp stem cells via CD44.2016
- Author(s)
  Naoki Umemura, Emika Ohkoshi, Masamichi Tajima, Hirotaka Kikuchi, Tadashi Katayama and Hiroshi Sakagami
- Journal Title
  
  Stem Cell Res Ther
  
  Volume: 7 Pages: 135-146
- DOI
  10.1186/s13287-016-0399-8
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462854, KAKENHI-PROJECT-26462892, KAKENHI-PROJECT-26861748
[Journal Article] Podoplanin expression in odontomas : clinicopathological study and immunohistochemical analysis of 86 case2010
- Author(s)
  Gonzalez-Alva P, Inoue H, Miyazaki Y, Tsuchiya H, Noguchi Y, Kikuchi K, Ide F, Ishihara S, Katayama T, Sakashita H, Kusama K
- Journal Title
  
  Joumal of Oral Science 53(1)
  
  Pages: 67-75
- NAID
  130000659038
- Data Source
  KAKENHI-PROJECT-20592232
[Journal Article] Podoplanin expression in odontomas : clinicopathological study and immunohistochemical analysis of 86 case2010
- Author(s)
  Gonzalez-Alva P, Inoue H, Miyazaki Y, Tsuchiya H, Noguchi Y, Kikuchi K, Ide F, Ishihara S, Katayama T, Sakashita H, Kusama K
- Journal Title
  
  Journal of Oral Science
  
  Volume: 53(1) Pages: 67-75
- NAID
  130000659038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592232
[Journal Article]2009
- Author(s)
  須田朋代,菊地寛高,田島雅道,龍田恒康,岩坂憲助,片山直
- Journal Title
  
  歯界展望『めざせ!健・口・美-未来に向けた歯科医療-』増刊号
  
  Pages: 0-0
- Data Source
  KAKENHI-PROJECT-18592097
[Journal Article] 臨床分離Staphylococcus aureusに対する水酸化カルシウムの抗菌活性のin vitroにおける評価2007
- Author(s)
  菊地寛高,高橋哲哉,呉崇史,杉山僚,須田朋代,小林健二,片山直
- Journal Title
  
  日歯保存誌 50 (1)
  
  Pages: 75-79
- NAID
  110007151144
- Data Source
  KAKENHI-PROJECT-18592097
[Journal Article] 臨床分離Staphylococcus aureusに対する水酸化カルシウムの抗菌活性のin vitroにおける評価2007
- Author(s)
  菊地寛高, 高橋哲哉, 呉崇史, 杉山僚, 須田朋代, 小林健二,片山直
- Journal Title
  
  日本歯科保存学雑誌 50・1
  
  Pages: 75-79
- NAID
  110007151144
- Data Source
  KAKENHI-PROJECT-18592097
[Journal Article] Inhibitry effects of platelet-rich plasma on osteoclast defferentiation by RAW264.7 cells.2006
- Author(s)
  Kikuchi H, Duan J, Kobayashi K, Suda T, Satoh M, Sugi Y, Katayama T, Nishikawa H.
- Journal Title
  
  J Hard Tissue Biology 14・2
  
  Pages: 99-100
- Data Source
  KAKENHI-PROJECT-18592097
[Journal Article] ヒト歯髄細胞のPGE2産生に対する多血小板血漿(platelet-rich plasma)および洗浄血小板の作用2006
- Author(s)
  段建民, 菊地寛高, 須田朋代, 田島雅道, 佐藤雅, 杉祐紀, 小林健二, 坂上宏,片山直
- Journal Title
  
  日本歯科保存学雑誌 49・2
  
  Pages: 152-157
- NAID
  110007151122
- Data Source
  KAKENHI-PROJECT-18592097
[Journal Article] Inhibitory effects of platelet-rich plasma on osteoclast differentiation in RAW264.7 cells.2006
- Author(s)
  Kikuchi H, Duan J, Kobayashi K, Suda T, Satho M, Sugi Y, Katayama T and Nishikawa H
- Journal Title
  
  J Hard Tissue Biol. 14(2)
  
  Pages: 98-100
- NAID
  110005853474
- Data Source
  KAKENHI-PROJECT-18592097
[Journal Article] ヒト歯髄細胞のPGE_2産生に対する多血小板血漿(platelet-rich plasma)及び洗浄血小板の作用2006
- Author(s)
  段建民、菊地寛高、須田朋代、佐藤雅、田島雅道、坂上宏、片山直
- Journal Title
  
  日本歯科保存学会誌 49 (3)
  
  Pages: 426-434
- Data Source
  KAKENHI-PROJECT-18592097
[Journal Article] マクロファージ活性化に対する多血小板血漿および洗浄血小板の効果2005
- Author(s)
  須田朋代,菊地寛高,高山直士,田島雅道,佐藤雅,杉祐紀,矢島晃司,嶋田淳,坂上宏,西川博文
- Journal Title
  
  日歯保存誌 48
  
  Pages: 152-157
- Data Source
  KAKENHI-PROJECT-18592097
[Journal Article] Cytotoxic activity strylchromones against human tumor cell lines.2005
- Author(s)
  Momoi K, Sugita Y, Ishihara M, Satoh K, Kikuchi H et al.
- Journal Title
  
  In vivo 19・1
  
  Pages: 157-164
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] マウスマクロファージ活性化に対する多血小板血漿及び洗浄血小板の効果2005
- Author(s)
  須田朋代, 菊地寛高, 高山直士他
- Journal Title
  
  日本歯科保存学雑誌 48・1
  
  Pages: 152-157
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Cytotoxicity and radical modulating activity of isoflavones and isoflavones from Sophora species2004
- Author(s)
  Shirataki Y, Wakae M, Yamamoto Y, Hashimoto K, Satoh K, Ishihara M, Kikuchi H, Nishikawa H, Minagawa K, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 1481-1488
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Structure -activity relationships of a, b-unsaturated ketones as assessed by their cytotoxicity against oral tumor cells2004
- Author(s)
  Nakayachi T, Yasumoto E, Nakano K, Morshed SRM, Hashimoto K, Kikuchi H, Nishikawa H, Kawase M, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 737-742
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Induction of apoptosis by b-diketones in human tumor cells.2004
- Author(s)
  Nakano K, Nakayachi T, Yasumoto E, Kikuchi H et al.
- Journal Title
  
  Anticancer Res. 24
  
  Pages: 711-718
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Structure-activity relationships of a, b-unsaturated ketones as assessed by their cytotoxicity against oral tumor cells.2004
- Author(s)
  Nakayachi T, Yasumoto E, Nakano K, Hashimoto K, Kikuchi H, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 737-742
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Cytotoxic activity of deferiprone, maltol and rerated hydroxyketones against human tumor cell lines.2004
- Author(s)
  Yasumoto E, Nakano K, Nakayachi T. Kikuchi H et al.
- Journal Title
  
  Anticancer Res. 24
  
  Pages: 755-762
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Cytotoxicity and radical modulating activity of isoflavones and isofravones from Sophora species.2004
- Author(s)
  Shirataki Y, Wakae M, Hashimoto K, Kikuchi H, Nishikawa H, Sakagami H
- Journal Title
  
  Anticancer Res 24
  
  Pages: 1481-1488
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Cytotoxic activity of tropolones against human oral tumor cell lines.2003
- Author(s)
  Wakabayashi H, Yokoyama K, Hashiba K, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Sakagami H
- Journal Title
  
  Anticancer Res 23
  
  Pages: 2385-2389
- NAID
  120005520607
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Cytotoxic activity of tropolones against human oral tumor cell lines2003
- Author(s)
  Wakabayashi H, Yokoyama K, Hashiba K, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Satoh K, Shioda S, Muto S, Terakubo S, Nakashima H, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 23
  
  Pages: 2385-2389
- NAID
  120005520607
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Cytotoxic activity of azulenes against human oral tumor cell lines2003
- Author(s)
  Wakabayashi H, Hashiba K, Yokoyama K, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Satoh K, Shioda S, Saito S, Kusano S, Nakashima H, Motohashi N, Sakagami H
- Journal Title
  
  Anticancer Res 23
  
  Pages: 3237-3241
- NAID
  120005520608
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Cytotoxic activity of azulenes against human oral tumor cell lines.2003
- Author(s)
  Wakabayashi H, Hashiba K, Yokoyama K, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Sakagami H
- Journal Title
  
  Anticancer Res 23
  
  Pages: 3237-3241
- NAID
  120005520608
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Transforming growth factor-beta 1 inhibits nitric oxide production of mouse osteoblastic cell line MC3T3-E1 through modulation of nuclear factor k-B activation2002
- Author(s)
  Kikuchi H, Furuya K, Shimada K, Kobayashi K, Suda T, Nakamura Y, Uchida A, Kotani Y, Sakata K, Nishikawa H
- Journal Title
  
  Meikai Univ Dent J 31
  
  Pages: 204-209
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Journal Article] Transforming growth factor-beta1 inhibits nitric oxide production of mouse osteoblastic cell line MC3T3-E1 through modulation of nuclear factor-kB activation2002
- Author(s)
  Kikuchi, H., Furuya, K., Shimada, K., Nishikawa, H.
- Journal Title
  
  Meikai Univ Dent J 31
  
  Pages: 204-209
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571821
[Presentation] 自己由来増殖因子による歯髄細胞の増殖および分化誘導活性の調節2008
- Author(s)
  須田朋代, 菊地寛高, 田島雅道, 岩坂憲助, 龍田恒康, 片山直, 中村幸雄
- Organizer
  第21回日本歯科医学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-18592097
[Presentation] Effects of Washed Platelets on osteoclast differentiation.2007
- Author(s)
  Tomoyo Suda, Hirotaka Kikuchi, and Tadashi Katayama.
- Organizer
  JADR.
- Data Source
  KAKENHI-PROJECT-18592097
[Presentation] Effect of Washed Platelets on osteoclast differentiation2007
- Author(s)
  Suda T, Kikuchi H, Katayama T
- Organizer
  JADR annual meeting
- Place of Presentation
  Tsurumi, Japan
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-18592097
[Presentation] 洗浄血小板抽出液によるヒト歯髄細胞のオステオカルシン発現の調節2007
- Author(s)
  菊地寛高、須田朋代、高橋哲哉、呉崇史杉山僚、小林健二、片山直
- Organizer
  日本歯科保存学会総会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-18592097
[Presentation] 4-トリフルオロメチルイミダゾール誘導体の腫瘍選択性と誘導される細胞死のタイプ
- Author(s)
  竹川文弘、岸野香織、天野修、菊地寛高、石原真理子、坂上宏
- Organizer
  第50回歯科基礎医学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20592232
[Presentation] 自己由来増殖因子による歯髄細胞の増殖および分化誘導活性の調節
- Author(s)
  須田朋代, 菊地寛高, 田島雅道, 岩坂憲助, 龍田恒康, 片山直, 中村幸雄
- Organizer
  第21回日本歯科医学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20592232

1. KATAYAMA Katayama (10105596)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
2. HANAZAWA Shigemasa (60060258)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. AMANO Shigeru (90167958)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. IAWSAKA Kensuke (60424058)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. SAKAGAMI Hiroshi (50138484)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
6. KITANO Shigeo (30049374)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TAKESHITA Akira (70236454)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SUDA Tomoyo (60226579)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
9. TAJIMA Masamichi (70130995)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
10. TATSUTA Tsuneyasu (40245163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. NAKAMURA Yukio (40207931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. ISHIHARA Satiyo (10223017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. SHIOTA Susumu (00150467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. WATANABE Kazuyuki (20271231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MIYATA Takashi (10146251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 梅村直己 (80609107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 村上幸生 (00286014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OHKOSHI Emika

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

KIKUCHI Hirotaka 菊地 寛高

菊地 寛高 キクチ ヒロタカ

菊池 寛高 キクチ ヒロタカ

Research Projects

Research Products

Co-Researchers

Analysis of PI3-kinase/Akt signaling on the osteogenesis of dental pulp stem cells in human.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis and significance of the autoderived-growthfactor as a stimulator of the proliferation and the differentiation of human dental pulp stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The improvement PRP treatment was investigate the applied likelihood to endodontic treatment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibitory Effects of Antimicrobial Agent Macrolides on LPS-induced periodontal destruction in periapical region.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and application of functional active domain of P.gingivalis fimbriae

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanism of expression of ODF and OCIF genes in P.gingivalis LPS-induced bone resorption.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

P．gingivalis線毛免疫による歯周組織破壊に関する防御機構の解析

Principal Investigator

Project Period (FY)

Research Category

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[Journal Article] Hyaluronan induces odontoblastic differentiation of dental pulp stem cells via CD44.2016

Author(s)

KIKUCHI Hirotaka 菊地寛高

菊地寛高キクチヒロタカ

菊池寛高キクチヒロタカ