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AMANO Shigeru  天野 滋

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… Alternative Names

天野 滋  アマノ シゲル

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Researcher Number 90167958
Other IDs
Affiliation (Current) 2020: 明海大学, 歯学部, 准教授
Affiliation (based on the past Project Information) *help 2020: 明海大学, 歯学部, 准教授
2018: 明海大学, 歯学部, 准教授
2010 – 2016: 明海大学, 歯学部, 准教授
2006: Meikai Univ., Dentistry, Associate Prof., 歯学部, 准教授
2000 – 2006: Meikai Univ. School. of Dent. Assoc. Prof., 歯学部, 助教授 … More
1999: 明海大学, 歯学部, 講師
1997: 明海大, 歯学部, 講師
1991 – 1996: Meikai University School of Dentistry Instructor, 歯学部, 講師
1993: 明海大学, 医学部, 講師
1990: 明海大学, 歯学部, 助手
1986 – 1987: 城西歯科大学, 歯学部, 助手 Less
Review Section/Research Field
Principal Investigator
Morphological basic dentistry / Morphological basic dentistry / Pathobiological dentistry/Dental radiology
Except Principal Investigator
Morphological basic dentistry / Morphological basic dentistry / Periodontal dentistry / Functional basic dentistry / Basic Section 57060:Surgical dentistry-related / Basic Section 57010:Oral biological science-related
Keywords
Principal Investigator
破骨細胞 / 破骨細胞前駆細胞株4B12細胞 / ODF / 破骨細胞分化 / CD13 / 破骨細胞形成 / Fibronectin / 分化 / Osteoclast / SCL … More / LPS / IL-6 / OCIF / CD14 / TLR4 / 骨吸収 / RANKL / bone resorption / 細胞分化 / 組織形成 / 発生 / 分化制御 / 骨代謝学 / 免疫 / 感染 / 炎症 / 内因性Wntシグナル / β-catenin / GSK-3β阻害 / TCF/LEF / DC-STAMP / Wnt / canonical経路 / Tm7sf4 / Sclerostin / 破細胞分化 / 破骨細胞上駆細胞株4B12細胞 / sFrp2 / sclerostin / β-カテニン / siRNA / 破骨細胞前駆細胞機能維持因子 / Insulin / Fibronectin N末端 / IGFBP-2 / Nidogen-2 / 破骨細胞前駆細胞株4B12細胞 / 破骨細胞前駆細胞分化機能維持因子 / 骨基質 / Differentiation / Bone matrix / 核内転写因子 / 骨吸収機能 / Bone-resorbing function / Transcriptional factor / IL-1β / TNFα / ST-2 / P.gingivalis GroEL / γδT細胞 / P. gingivalis groEL / γδ T細胞 / Porphyromonas gingivails / HSP / T cell / P. gingivalis GroEL / γδT cells / プロテオーム / リン酸化蛋白質 / ERK / p38 / JNK / c-Fos / NFATcl / リン酸化タンパク質 / リン酸化タンパク / AP-1 / NFATc / 走化性 / ケモカインレセプター / ケモカイン / Proteome / Osteoclasts / Phosphorylated proteins / CD13 / NGR配列 / がん細胞 / HT1080 / 歯学 / 細菌 / 免疫学 / 発生・分化 / シグナル伝達 … More
Except Principal Investigator
サイトカイン / 遺伝子発現 / P.gingivalis / 炎症 / 歯周疾患 / Inflammation / Gene expression / Cytokine / 線毛 / 脂肪酸 / 酪酸 / T細胞 / アポトーシス / 線維芽細胞 / 歯周病 / Apoptosis / Butyric acid / Porphyromanas gingivalis / クロモン誘導体 / 歯肉線維芽細胞 / 歯周病病原性細菌 / Cytokines / Gingival fibroblasts / Periodonal pathogen / Periodontal disease / 歯周組織 / 情報伝達 / ネットワーク機構 / 骨芽細胞 / TGT-beat / 単球走化性因子 / Pgingivalis / 歯周ポケット / Periodontal tissues / Signal transduction / Network mechanism / 骨吸収作用 / ワクチン / P..gingivalis / Fimbriae / Bone resorption / Vaccination / 成人性歯周病 / 遺伝子組換え / マクロファージ / 活性部位 / 骨吸収 / レセプター / 遺伝子組み換え / Fibronectin / adult periodontitis / fimbriae / recombination / macrophages / active domain / gene expression / bone resorption / 歯周病原菌 / 接着因子 / 嫌気性菌 / Periodontitis / Anaerobic bacteria. / Fatty acids / T-cell Fibroblast / Adhesion molecules / 接着分子 / 上皮細胞 / tight junction / T cell / Fibroblast / Adhesion molecule / Short-chain fatty acid / 内毒素 / 合成リピドA / 生物活性 / 化学合成 / periodontal disease / lipopolysaccharide / synthetic lipid A / biological properties / 単一クローン抗体 / 歯周疾患関連細菌 / 診断学への応用 / B.gingivalis / 特異精製抗原 / Monoclonal antibody / Periodontal disease associated bacteria / ハイパーサーミア / 口腔癌 / 細胞透過性ペプチド / Geranylgeraniol / 選択毒性 / 細胞死 / 口腔扁平上皮癌 / シグナル伝達 Less
  • Research Projects

    (19 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (35 People)
  •  Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticlesOngoing

    • Principal Investigator
      藤内 祝
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Meikai University
  •  Elucidation of selective cytotoxicity against malignant cells by chromone derivativesOngoing

    • Principal Investigator
      坂上 宏
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57010:Oral biological science-related
    • Research Institution
      Meikai University
  •  Clarification of the role of CD13 combined with N-terminal fragment of fibronectin on inflammatory bone resorption.Principal Investigator

    • Principal Investigator
      AMANO Shigeru
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Meikai University
  •  Identification of stromal cell-derived factors required for maintaining functional osteoclast precursors and elucidation of the role of the factors in inflammatory bone destructionPrincipal Investigator

    • Principal Investigator
      Amano Shigeru
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Meikai University
  •  Investigation of the role of endogenous Wnt signaling in osteoclast differentiation and functionPrincipal Investigator

    • Principal Investigator
      AMANO Shigeru
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Meikai University
  •  A drug development study for a periodontal disease : Biological properties of synthetic lipid A of Porphyromonas gingivalis lipopolysaccharide

    • Principal Investigator
      KUMADA Hidefumi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Kanagawa Dental College
  •  Apoptosis induced by butyric acid modulates immunoresponses : Role of epitherial cells and fibroblasts in inhibiting butyric acid-induced T cell apoptosis

    • Principal Investigator
      OCHIAI Kuniyasu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Nihon University
      Meikai University
  •  Proteome analysis of phosphorylated proteins associated with osteoclast formation using established osteoclast precursor cell linePrincipal Investigator

    • Principal Investigator
      AMANO Shigeru
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Meikai University
  •  Effects of adhesion molecules and mechanism of gingival fibroblast rescue butyric acid-induced T-cell apoptosis.

    • Principal Investigator
      OCHIAI Kuniyasu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Meikai University
  •  The study of an effect of Porphyromonas gingivalis heat shock protein on bone resorptionPrincipal Investigator

    • Principal Investigator
      AMANO Shigeru
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Meikai University
  •  Identification and application of functional active domain of P.gingivalis fimbriae

    • Principal Investigator
      HANAZAWA Shigemasa
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Morphological basic dentistry
    • Research Institution
      KYUSHU UNIVERSITY
      Meikai University
  •  Regulatory mechanism of expression of ODF and OCIF genes in P.gingivalis LPS-induced bone resorption.Principal Investigator

    • Principal Investigator
      AMANO Shigeru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Meikai University
  •  破骨細胞の骨吸収機能発現におけるシスエレメントE−boxの役割Principal Investigator

    • Principal Investigator
      天野 滋
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Meikai University
  •  Role of basic helix-loop-helix SCL protein in osteoclast differentiationPrincipal Investigator

    • Principal Investigator
      AMANO Shigeru
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Meikai University
  •  P.gingivalis線毛の成人型歯周疾患ワクチンへの応用に関する基礎的研究

    • Principal Investigator
      KITANO Shigeo
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Meikai University
  •  Purification and identification of factors involved in osteoclastic maturation from bovine bone matrixPrincipal Investigator

    • Principal Investigator
      AMANO Shigeru
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Meikai University
  •  Gene expression of inflammatory cytokines in periodontal tissues and network of thier cytokines

    • Principal Investigator
      HANAWAWA Shigemasa
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Meikai University, School of Dentistry
  •  Regulation of Cytokines for Gene Expression and Function of Gingival Fibroblasts

    • Principal Investigator
      HANAZAWA Shigemasa
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Morphological basic dentistry
    • Research Institution
      Miekai University School of Dentistry
  •  Application for diagnosis of B.gingivalis-specific monoclonal antibody in periodontal disease.

    • Principal Investigator
      HANAZAWA Shigemasa
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Josai dental University, Dept. of Oral Microbiology

All 2015 2014 2012 2011 2004

All Journal Article Presentation

  • [Journal Article] ERK5 activation is essential for osteoclast differentiation2015

    • Author(s)
      Shigeru Amano, Yu-Tzu Chang, Yasuhisa Fukui
    • Journal Title

      PLOS ONE

      Volume: 10(4)

    • DOI

      10.1371/journal.pone.0125054

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25670799
  • [Journal Article] Osteocalcin fragment in bone matrix enhances osteoclast maturation at a late stare of osteoclast differentiation2004

    • Author(s)
      Masami Ishida, Shigeru Amano
    • Journal Title

      J bone Miner Metab 22・5

      Pages: 415-429

    • Data Source
      KAKENHI-PROJECT-16591835
  • [Journal Article] Osteocalcin fragment in bone matrix enhances osteoclast maturation at a late stage ofosteoclast differentiation.2004

    • Author(s)
      Masami Ishida, Shigeru Amano
    • Journal Title

      J Bone Miner Metab 22・5

      Pages: 415-429

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16591835
  • [Journal Article] Osteocalcin fragment in bone matrix enhances osteoclast maturation at a late stage ofosteoclast differentiation.2004

    • Author(s)
      Masami Ishida, Shigeru Amano
    • Journal Title

      J Bone Miner Metab Vol-22

      Pages: 415-429

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591835
  • [Presentation] ERK5 activation is essential for osteoclast differentiation2015

    • Author(s)
      Shigeru Amano, Yu-Tzu Chang, Yasuhisa Fukui
    • Organizer
      4th Joint Meeting of ECTS and IBMS
    • Place of Presentation
      Rotterdam, The Netherlands
    • Year and Date
      2015-04-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25670799
  • [Presentation] Roles of N-terminal region of Fibronectin in maintaining of osteoclast precursors2015

    • Author(s)
      Shigeru Amano, Yoshihiro Ohmori
    • Organizer
      The 57th Annual Meeting of The Japanese Association for Oral Biology
    • Place of Presentation
      新潟コンベンションセンター、新潟県新潟市
    • Year and Date
      2015-09-11
    • Data Source
      KAKENHI-PROJECT-25670799
  • [Presentation] 間質細胞から産生されている破骨細胞前駆細胞分化機能維持に影響する因子について2014

    • Author(s)
      天野滋、大森喜弘
    • Organizer
      第56回歯科基礎医学会学術大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-09-27
    • Data Source
      KAKENHI-PROJECT-25670799
  • [Presentation] Wnt6/・-catenin シグナルは DC-STAMP の発現を上昇させることによって破骨細胞の融合を促進する2012

    • Author(s)
      天野 滋、大森喜弘
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      奥羽大学記念講堂
    • Year and Date
      2012-09-16
    • Data Source
      KAKENHI-PROJECT-22592047
  • [Presentation] Wnt6/β-cateninシグナルはDC-STAMPの発現を上昇させることによって破骨細胞の融合を促進する2012

    • Author(s)
      天野 滋
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      奥羽大学
    • Data Source
      KAKENHI-PROJECT-22592047
  • [Presentation] 破骨細胞分化における内因性Wntシグナルの役割2011

    • Author(s)
      天野滋
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜長良川国際会議場
    • Year and Date
      2011-10-01
    • Data Source
      KAKENHI-PROJECT-22592047
  • [Presentation] 破骨細胞分化における内因性 Wnt シグナルの役割2011

    • Author(s)
      天野 滋、関根圭輔、大森喜弘
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場
    • Year and Date
      2011-10-01
    • Data Source
      KAKENHI-PROJECT-22592047
  • 1.  HANAZAWA Shigemasa (60060258)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  TAKESHITA Akira (70236454)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  KIKUCHI Hirotaka (70234193)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  TAGAWA Yumi (20348189)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  SEKINE Keisuke (00323569)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  OCHIAI Kuniyasu (50095444)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  奥平 准之 (10635585)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  杉田 義昭 (20255029)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  坂上 宏 (50138484)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  坂東 健二郎 (50347093)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  高尾 浩一 (70337484)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  植沢 芳広 (90322528)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  KITANO Shigeo (30049374)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  SHIOTA Susumu (00150467)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  WATANABE Kazuyuki (20271231)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MIYATA Takashi (10146251)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  OCHIAI Kurita tomoko (20130594)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  AMANO Osamu (60193025)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  SETO Shintaro (50383203)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  KUMADA Hidefumi (60120995)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  WATANABE Kiyoko (70148021)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  HAISHIMA Yuji (80228379)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  HAMADA Nobushiro (20247315)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TAKAHASHI Yusuke (20267511)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  大森 喜弘 (50194311)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  斉藤 貴江子 (10162190)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  三好 武仁 (90174226)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  藤内 祝 (50172127)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  坂下 英明 (10178551)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  友村 美根子 (30217559)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  光藤 健司 (70303641)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  小泉 敏之 (80323575)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  中鍛治 里奈 (80845511)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  田沼 靖一 (10142449)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  佐藤 聡 (40530663)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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