AMANO Shigeru 天野滋

… Alternative Names

Researcher Number	90167958
Other IDs
Affiliation (Current)	2021: 明海大学, 歯学部, 准教授
Affiliation (based on the past Project Information) *help	2020: 明海大学, 歯学部, 准教授 2010 – 2018: 明海大学, 歯学部, 准教授 2006: Meikai Univ., Dentistry, Associate Prof., 歯学部, 准教授 2000 – 2006: Meikai Univ. School. of Dent. Assoc. Prof., 歯学部, 助教授 1999: 明海大学, 歯学部, 講師 … More
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Morphological basic dentistry / Pathobiological dentistry/Dental radiology Except Principal Investigator Morphological basic dentistry / Morphological basic dentistry / Periodontal dentistry / Functional basic dentistry / Basic Section 57060:Surgical dentistry-related / Basic Section 57010:Oral biological science-related
Keywords	Principal Investigator 破骨細胞 / 破骨細胞前駆細胞株4B12細胞 / ODF / 破骨細胞分化 / CD13 / 破骨細胞形成 / Fibronectin / 分化 / Osteoclast / SCL … More Except Principal Investigator サイトカイン / 遺伝子発現 / P.gingivalis / 炎症 / 歯周疾患 / Inflammation / Gene expression / Cytokine / 線毛 / 脂肪酸 / 酪酸 / T細胞 / アポトーシス / 線維芽細胞 / 歯周病 / Apoptosis / Butyric acid / Porphyromanas gingivalis / クロモン誘導体 / 歯肉線維芽細胞 / 歯周病病原性細菌 / Cytokines / Gingival fibroblasts / Periodonal pathogen / Periodontal disease / 歯周組織 / 情報伝達 / ネットワーク機構 / 骨芽細胞 / TGT-beat / 単球走化性因子 / Pgingivalis / 歯周ポケット / Periodontal tissues / Signal transduction / Network mechanism / 骨吸収作用 / ワクチン / P..gingivalis / Fimbriae / Bone resorption / Vaccination / 成人性歯周病 / 遺伝子組換え / マクロファージ / 活性部位 / 骨吸収 / レセプター / 遺伝子組み換え / Fibronectin / adult periodontitis / fimbriae / recombination / macrophages / active domain / gene expression / bone resorption / 歯周病原菌 / 接着因子 / 嫌気性菌 / Periodontitis / Anaerobic bacteria. / Fatty acids / T-cell Fibroblast / Adhesion molecules / 接着分子 / 上皮細胞 / tight junction / T cell / Fibroblast / Adhesion molecule / Short-chain fatty acid / 内毒素 / 合成リピドA / 生物活性 / 化学合成 / periodontal disease / lipopolysaccharide / synthetic lipid A / biological properties / 単一クローン抗体 / 歯周疾患関連細菌 / 診断学への応用 / B.gingivalis / 特異精製抗原 / Monoclonal antibody / Periodontal disease associated bacteria / ハイパーサーミア / 口腔癌 / 細胞透過性ペプチド / Geranylgeraniol / 選択毒性 / 細胞死 / 口腔扁平上皮癌 / シグナル伝達 Less

Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticlesOngoing
- Principal Investigator
  
  藤内祝
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Meikai University
Elucidation of selective cytotoxicity against malignant cells by chromone derivativesOngoing
- Principal Investigator
  
  坂上宏
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Meikai University
Clarification of the role of CD13 combined with N-terminal fragment of fibronectin on inflammatory bone resorption.Principal Investigator
- Principal Investigator
  
  AMANO Shigeru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Meikai University
Identification of stromal cell-derived factors required for maintaining functional osteoclast precursors and elucidation of the role of the factors in inflammatory bone destructionPrincipal Investigator
- Principal Investigator
  
  Amano Shigeru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Meikai University
Investigation of the role of endogenous Wnt signaling in osteoclast differentiation and functionPrincipal Investigator
- Principal Investigator
  
  AMANO Shigeru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
A drug development study for a periodontal disease : Biological properties of synthetic lipid A of Porphyromonas gingivalis lipopolysaccharide
- Principal Investigator
  
  KUMADA Hidefumi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Kanagawa Dental College
Apoptosis induced by butyric acid modulates immunoresponses : Role of epitherial cells and fibroblasts in inhibiting butyric acid-induced T cell apoptosis
- Principal Investigator
  
  OCHIAI Kuniyasu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Nihon University
  Meikai University
Proteome analysis of phosphorylated proteins associated with osteoclast formation using established osteoclast precursor cell linePrincipal Investigator
- Principal Investigator
  
  AMANO Shigeru
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Effects of adhesion molecules and mechanism of gingival fibroblast rescue butyric acid-induced T-cell apoptosis.
- Principal Investigator
  
  OCHIAI Kuniyasu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
The study of an effect of Porphyromonas gingivalis heat shock protein on bone resorptionPrincipal Investigator
- Principal Investigator
  
  AMANO Shigeru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Identification and application of functional active domain of P.gingivalis fimbriae
- Principal Investigator
  
  HANAZAWA Shigemasa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Morphological basic dentistry
- Research Institution
  KYUSHU UNIVERSITY
  Meikai University
Regulatory mechanism of expression of ODF and OCIF genes in P.gingivalis LPS-induced bone resorption.Principal Investigator
- Principal Investigator
  
  AMANO Shigeru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
破骨細胞の骨吸収機能発現におけるシスエレメントE−boxの役割Principal Investigator
- Principal Investigator
  
  天野滋
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Role of basic helix-loop-helix SCL protein in osteoclast differentiationPrincipal Investigator
- Principal Investigator
  
  AMANO Shigeru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
P.gingivalis線毛の成人型歯周疾患ワクチンへの応用に関する基礎的研究
- Principal Investigator
  
  KITANO Shigeo
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Purification and identification of factors involved in osteoclastic maturation from bovine bone matrixPrincipal Investigator
- Principal Investigator
  
  AMANO Shigeru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University
Gene expression of inflammatory cytokines in periodontal tissues and network of thier cytokines
- Principal Investigator
  
  HANAWAWA Shigemasa
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Meikai University, School of Dentistry
Regulation of Cytokines for Gene Expression and Function of Gingival Fibroblasts
- Principal Investigator
  
  HANAZAWA Shigemasa
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Miekai University School of Dentistry
Application for diagnosis of B.gingivalis-specific monoclonal antibody in periodontal disease.
- Principal Investigator
  
  HANAZAWA Shigemasa
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Josai dental University, Dept. of Oral Microbiology

All 2015 2014 2012 2011 2004

All Journal Article Presentation

[Journal Article] ERK5 activation is essential for osteoclast differentiation2015
- Author(s)
  Shigeru Amano, Yu-Tzu Chang, Yasuhisa Fukui
- Journal Title
  
  PLOS ONE
  
  Volume: 10(4)
- DOI
  10.1371/journal.pone.0125054
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25670799
[Journal Article] Osteocalcin fragment in bone matrix enhances osteoclast maturation at a late stage ofosteoclast differentiation.2004
- Author(s)
  Masami Ishida, Shigeru Amano
- Journal Title
  
  J Bone Miner Metab 22・5
  
  Pages: 415-429
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591835
[Journal Article] Osteocalcin fragment in bone matrix enhances osteoclast maturation at a late stare of osteoclast differentiation2004
- Author(s)
  Masami Ishida, Shigeru Amano
- Journal Title
  
  J bone Miner Metab 22・5
  
  Pages: 415-429
- Data Source
  KAKENHI-PROJECT-16591835
[Journal Article] Osteocalcin fragment in bone matrix enhances osteoclast maturation at a late stage ofosteoclast differentiation.2004
- Author(s)
  Masami Ishida, Shigeru Amano
- Journal Title
  
  J Bone Miner Metab Vol-22
  
  Pages: 415-429
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591835
[Presentation] Roles of N-terminal region of Fibronectin in maintaining of osteoclast precursors2015
- Author(s)
  Shigeru Amano, Yoshihiro Ohmori
- Organizer
  The 57th Annual Meeting of The Japanese Association for Oral Biology
- Place of Presentation
  新潟コンベンションセンター、新潟県新潟市
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-25670799
[Presentation] ERK5 activation is essential for osteoclast differentiation2015
- Author(s)
  Shigeru Amano, Yu-Tzu Chang, Yasuhisa Fukui
- Organizer
  4th Joint Meeting of ECTS and IBMS
- Place of Presentation
  Rotterdam, The Netherlands
- Year and Date
  2015-04-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25670799
[Presentation] 間質細胞から産生されている破骨細胞前駆細胞分化機能維持に影響する因子について2014
- Author(s)
  天野滋、大森喜弘
- Organizer
  第56回歯科基礎医学会学術大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-25670799
[Presentation] Wnt6/β-cateninシグナルはDC-STAMPの発現を上昇させることによって破骨細胞の融合を促進する2012
- Author(s)
  天野　滋
- Organizer
  第54回歯科基礎医学会学術大会
- Place of Presentation
  奥羽大学
- Data Source
  KAKENHI-PROJECT-22592047
[Presentation] Wnt6/・-catenin シグナルは DC-STAMP の発現を上昇させることによって破骨細胞の融合を促進する2012
- Author(s)
  天野滋、大森喜弘
- Organizer
  第54回歯科基礎医学会学術大会
- Place of Presentation
  奥羽大学記念講堂
- Year and Date
  2012-09-16
- Data Source
  KAKENHI-PROJECT-22592047
[Presentation] 破骨細胞分化における内因性Wntシグナルの役割2011
- Author(s)
  天野滋
- Organizer
  第53回歯科基礎医学会学術大会
- Place of Presentation
  岐阜長良川国際会議場
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-22592047
[Presentation] 破骨細胞分化における内因性 Wnt シグナルの役割2011
- Author(s)
  天野滋、関根圭輔、大森喜弘
- Organizer
  第53回歯科基礎医学会学術大会
- Place of Presentation
  長良川国際会議場
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-22592047

1. HANAZAWA Shigemasa (60060258)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. TAKESHITA Akira (70236454)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. KIKUCHI Hirotaka (70234193)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TAGAWA Yumi (20348189)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. SEKINE Keisuke (00323569)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. OCHIAI Kuniyasu (50095444)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 奥平准之 (10635585)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 杉田義昭 (20255029)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 坂上宏 (50138484)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 坂東健二郎 (50347093)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 高尾浩一 (70337484)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 植沢芳広 (90322528)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. KITANO Shigeo (30049374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SHIOTA Susumu (00150467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. WATANABE Kazuyuki (20271231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MIYATA Takashi (10146251)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. OCHIAI Kurita tomoko (20130594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. AMANO Osamu (60193025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. SETO Shintaro (50383203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KUMADA Hidefumi (60120995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. WATANABE Kiyoko (70148021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HAISHIMA Yuji (80228379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. HAMADA Nobushiro (20247315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. TAKAHASHI Yusuke (20267511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 大森喜弘 (50194311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 斉藤貴江子 (10162190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 三好武仁 (90174226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 藤内祝 (50172127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 坂下英明 (10178551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 友村美根子 (30217559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 光藤健司 (70303641)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 小泉敏之 (80323575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 中鍛治里奈 (80845511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 田沼靖一 (10142449)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 佐藤聡 (40530663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AMANO Shigeru 天野 滋

天野 滋 アマノ シゲル

Research Projects

Research Products

Co-Researchers

Development of minimally invasive therapy for oral cancer by hyperthermia with tumor-specific targeting magnetic nanoparticlesOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of selective cytotoxicity against malignant cells by chromone derivativesOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of the role of CD13 combined with N-terminal fragment of fibronectin on inflammatory bone resorption.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of stromal cell-derived factors required for maintaining functional osteoclast precursors and elucidation of the role of the factors in inflammatory bone destructionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the role of endogenous Wnt signaling in osteoclast differentiation and functionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Proteome analysis of phosphorylated proteins associated with osteoclast formation using established osteoclast precursor cell linePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of an effect of Porphyromonas gingivalis heat shock protein on bone resorptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulatory mechanism of expression of ODF and OCIF genes in P.gingivalis LPS-induced bone resorption.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

破骨細胞の骨吸収機能発現におけるシスエレメントE−boxの役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of basic helix-loop-helix SCL protein in osteoclast differentiationPrincipal Investigator

AMANO Shigeru 天野滋

天野滋アマノシゲル