Kasai Kenji 笠井謙次

… Alternative Names

笠井謙次カサイケンジ

KASAI Kenji 笠井謙次

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Researcher Number	70242857
Other IDs
Affiliation (Current)	2025: 愛知医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023: 愛知医科大学, 医学部, 教授 2019 – 2021: 愛知医科大学, 医学部, 教授 2017: 愛知医科大学, 医学部, 教授 2007 – 2016: Aichi Medical University, 医学部, 准教授 1993 – 1994: Nagoya University School of Medicine, research Associate, 医学部, 助手
Review Section/Research Field	Principal Investigator Human pathology / Basic Section 49030:Experimental pathology-related / Basic Section 49020:Human pathology-related Except Principal Investigator Human pathology / Experimental pathology
Keywords	Principal Investigator ヘッジホッグ / 膵臓癌 / クロマチン制御 / FAM64A / 乳癌 / SIL / 分子病理 / がん / ENTREP / PD-L1 … More / ユビキチン / 細胞周期 / トリプルネガティブ / DNA修復機構 / トリプルネガティブ乳癌 / DNA複製 / 標的遺伝子 / 転写抑制因子 / DCIS / TSHZ2 / Hedgehog / 遺伝子制御 / Pak1 / ArhGEF7 / 細胞運動 / SIX3 / 前癌病変 / 癌 / 病理学 / 転移 / 浸潤 / シグナル伝達 … More Except Principal Investigator Dendritic cell / CD5positive B cell / Ellipsoidal sheath / Splenic marginal zone / Immunohistochemistry / Electron microsopy / Lymphomyeloid tissue / Fibroblastic reticular cell / 造血間質細胞 / モノクローナル抗体 / 電顕的画像解析 / 骨髄移植 / CD5陽性B細胞 / 濾胞周辺帯 / 免疫一次応答 / 細網内皮系 / 樹状細胞 / CDS陽性B細胞 / 脾臓莢組織 / 脾臓濾胞周辺帯 / 免疫組織化学 / 電顕的形態計測 / リンパ・造血組織 / 細網線維 / CDRIII / RT-PCR / PCR / 免疫グロブリン遺伝子 / Hodgkin病 / λ鎖様遺伝子 / VpreB / λ5 / non-T ALL Less

ENTREP-mediated modulation of PD-L1 ubiquitination and the tumor immunity.Principal Investigator
- Principal Investigator
  
  笠井謙次
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Aichi Medical University
Cell cycle regulation of triple-negative breast cancer by newly-identified nuclear protein network.Principal Investigator
- Principal Investigator
  
  Kasai Kenji
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Aichi Medical University
Downstream of newly identified transcriptional repressor and its role in the progression of non-invasive breast cancer.Principal Investigator
- Principal Investigator
  
  KASAI KENJI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Medical University
Hedgehog signaling molecule SIL regulates the migration and progression of pancreatic ductal adenocarcinoma.Principal Investigator
- Principal Investigator
  
  KASAI Kenji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Medical University
Roles of SIX3 and SIL in the Hedgehog signaling during pancreatic carcinogenesis.Principal Investigator
- Principal Investigator
  
  KASAI Kenji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Medical University
Roles of the Hedgehog signaling in invasion and metastasis of pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  KASAI Kenji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Aichi Medical University
ホジキン病における免疫グロブリン超可変領域の遺伝子的検討
- Principal Investigator
  
  森尚義
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagoya University
non-T ALLにおける免疫グロブリン入鎖高頻度発現の遺伝子的解明
- Principal Investigator
  
  森尚義
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Nagoya University
Studies on the structure of reticular framework and its micro-environment in the lymphoid
- Principal Investigator
  
  ASAI Junpei
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagoya University

All 2024 2022 2020 2019 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer2022
- Author(s)
  Takumi Tsunoda, Miho Riku, Norika Yamada, Hikaru Tsuchiya, Takuya Tomita, Minako Suzuki, Mari Kizuki, Akihito Inoko, Hideaki Ito, Kenta Murotani, Hideki Murakami, Yasushi Saeki, Kenji Kasai
- Journal Title
  
  EMBO reports
  
  Volume: 23 Issue: 2
- DOI
  10.15252/embr.202051182
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07449, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-19K06671, KAKENHI-PROJECT-20K16182, KAKENHI-PROJECT-20K16205
[Journal Article] Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex2020
- Author(s)
  Hideaki Ito, Takumi Tsunoda, Miho Riku, Shingo Inaguma, Akihito Inoko, Hideki Murakami, Hiroshi Ikeda, Michiyuki Matsuda & Kenji Kasai
- Journal Title
  
  Oncogene
  
  Volume: 39 Issue: 9 Pages: 1931-1943
- DOI
  10.1038/s41388-019-1115-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06671, KAKENHI-PROJECT-19K07449, KAKENHI-PROJECT-16K19091, KAKENHI-PROJECT-16H06280, KAKENHI-PLANNED-15H05949, KAKENHI-PROJECT-19H00993
[Journal Article] GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells2015
- Author(s)
  Shingo Inaguma, Miho Riku, Hideaki Ito, Takumi Tsunoda, Hiroshi Ikeda, Kenji Kasai
- Journal Title
  
  Oncotarget
  
  Volume: Vol6, No32 Issue: 32 Pages: 33648-33657
- DOI
  10.18632/oncotarget.5203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08358
[Journal Article] Down-regulation of the zinc-finger homeobox protein TSHZ2 releases GLI1 from the nuclear repressor complex to restore its transcriptional activity during mammary tumorigenesis2015
- Author(s)
  Miho Riku, Shingo Inaguma, Hideaki Ito, Takumi Tsunoda, Hiroshi Ikeda, Kenji Kasai
- Journal Title
  
  Oncotarget
  
  Volume: vol7, No5 Issue: 5 Pages: 5690-5701
- DOI
  10.18632/oncotarget.6788
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08358
[Journal Article] GLI1 interferes with the DNA mismatch repair system in pancreatic cancer through BHLHE41-mediated suppression of MLH1.2013
- Author(s)
  Shingo Inaguma, Miho Riku, Mitsuyoshi Hashimoto, Hideki Murakami, Shinsuke Saga, Hiroshi Ikeda and Kenji Kasai.
- Journal Title
  
  Cancer Research
  
  Volume: 73 Pages: 7313-7323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590456
[Journal Article] GLI1 modulates EMT in pancreatic cancer-Letter2012
- Author(s)
  Shingo Inaguma, Kenji Kasai, Mitsuyoshi Hashimoto, Hiroshi Ikeda
- Journal Title
  
  Cancer Research
  
  Volume: (in press) Issue: 14 Pages: 3702-3
- DOI
  10.1158/0008-5472.can-12-0379
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590408, KAKENHI-PROJECT-23790424, KAKENHI-PROJECT-24590456
[Journal Article] GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin2011
- Author(s)
  Shingo Inaguma, Kenji Kasai, Hiroshi Ikeda
- Journal Title
  
  Oncogene
  
  Volume: 30 Issue: 6 Pages: 714-723
- DOI
  10.1038/onc.2010.459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590408
[Journal Article] GLI1 facilitates the migarion and invasion of pancreatic cancer cellls through MUC5AC-mediated attenuation of E-cadherin.2011
- Author(s)
  S Inaguma, K Kasai, H Ikeda.
- Journal Title
  
  Oncogene
  
  Volume: 30巻 Pages: 714-723
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590408
[Journal Article] SCL/TAL1 Interrupting Locus derepresses GLI1 from the negative control of Suppressor-of-Fused in pancreatic cancer cell2008
- Author(s)
  Kenji Kasai, Shingo Inaguma, Akiko Yoneyama, Kazuhiro Yoshikawa, Hiroshi Ikeda
- Journal Title
  
  Cancer Research 66
  
  Pages: 7723-7729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590371
[Journal Article] SCL/TAL1 Interrupting Locus derepresses GLI1 from the negative control of Suppressor-of-Fused in pancreatic cancer cell2008
- Author(s)
  Kenji Kasai
- Journal Title
  
  Cancer Res 68
  
  Pages: 7723-7729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590371
[Journal Article] Paracrine factors of vascular endothelial cells facilitate cardiomyocyte differentiation of mouse embryonic stem cells2008
- Author(s)
  Miwako Kado, Jong-Kook Lee, Kyoko Hidaka, Keiko Miwa, Toyoaki Murohara, Kenji Kasai, Shinsuke Saga, Takayuki Morisaki, Yuichi Ueda, Itsuo Koodama
- Journal Title
  
  Biochemical and Biophysical Research Communications 377
  
  Pages: 413-418
- NAID
  120000976725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590371
[Journal Article] Versican and Fibrillin-1 form a major Hyaluronan-binding complex in the ciliary body2008
- Author(s)
  Akiko Ohno-Jinno, Zenzo Isogai, Masahiko Yoneda, Kenji Kasai, Osamu Miyaishi, Yoko Inoue, Takuya Kataoka, Jing-Song Zhao, Huili Li, Masayuki Takeyama, Douglas R. Keene, Lynn Y. Sakai, Koji Kimata, Masayoshi Iwaki, Masahiro Zako
- Journal Title
  
  Investigative Ophthalmology & Visual Science 49
  
  Pages: 2870-2877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590371
[Presentation] 小規模ラボの試み：乳癌予後予測因子 ENTREP1の同定と機能解析の経験2024
- Author(s)
  笠井謙次
- Organizer
  第113回日本病理学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06505
[Presentation] 網羅的遺伝子解析から着目した遺伝子産物FAM64Aの乳癌における臨床病理的解析2019
- Author(s)
  井戸美来、坂野福奈、伊藤由季絵、後藤真奈美、安藤考人、毛利有佳子、高坂絢子、藤井公人、笠井謙次、中野正吾
- Organizer
  第27回日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07449
[Presentation] ヘッジホッグ系転写因子GLI1はCXCL12/CXCR4経路の活性化により乳癌細胞の遊走能を亢進させる2015
- Author(s)
  稲熊真悟、笠井謙次、伊藤秀明、陸美穂、池田洋
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K08358
[Presentation] Hedgehogシグナル伝達から見た膵臓癌の分子病態（日本病理学会学術研究賞受賞講演）2015
- Author(s)
  笠井謙次
- Organizer
  第61回日本病理学会秋期特別総会
- Place of Presentation
  東京大学安田講堂
- Year and Date
  2015-11-05
- Invited
- Data Source
  KAKENHI-PROJECT-15K08358
[Presentation] 新規転写抑制因子TSHZ2からみた乳癌進展機構2015
- Author(s)
  陸美穂、笠井謙次、稲熊真悟、伊藤秀明、池田洋
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K08358
[Presentation] ヘッジホッグシグナル系転写因子ZIC2はFGFR3、ANXA8L2発現誘導を介して膵発がんを促進する2014
- Author(s)
  稲熊真悟、笠井謙次、橋本光義、陸美穂、池田洋
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場
- Data Source
  KAKENHI-PROJECT-24590456
[Presentation] ZIC2 is an indispensable transcriptional factor for the cell gwoth of pancreatic duct adenocarcinoma.2014
- Author(s)
  S Inaguma, K Kasai, M Hashimoto, M Riku, H Ikeda
- Organizer
  103rd Annuak Meeting of USCAP
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-24590456
[Presentation] Hedgehogシグナル系転写活性化因子GLI1から見た膵臓前がん病変の細胞生物学的特性2013
- Author(s)
  稲熊真悟、笠井謙次。橋本光義、陸美穂、池田洋
- Organizer
  第102回日本病理学会総会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-24590456
[Presentation] 膵臓癌細胞において転写因子GLI1はBHLHE41依存性にMLH1発現を抑制し、ミスマッチ修復機構の機能不全を惹起する2013
- Author(s)
  稲熊真悟、笠井謙次、橋本光義、陸美穂、池田洋
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24590456
[Presentation] 胃小細胞癌の一例:遺伝子変異LOH解析を含めた検討2011
- Author(s)
  稲熊真悟、笠井謙次、池田洋
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-04-29
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] 胃小細胞癌の一例遺伝子変異・LOH解析を含めた検討2011
- Author(s)
  稲熊真悟、笠井謙次、池田洋
- Organizer
  第100回日本病理学会総会
- Place of Presentation
  パシフィコ横浜(横浜市)(一般示説)
- Year and Date
  2011-04-29
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] GLI1はMUC5ACの発現誘導によってE-cadherinによる細胞間接着を阻害し膵癌細胞の遊走・浸潤を促進する2010
- Author(s)
  稲熊真悟、笠井謙次、米山亜紀子、池田洋
- Organizer
  第99回日本病理学会総会
- Place of Presentation
  京王プラザホテル(東京都)
- Year and Date
  2010-04-29
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] 膵臓癌においてGLI1はbHLH型転写抑制因子DEC2の発現を直接誘導しMLH1を介した遺伝子不安定性に寄与する2009
- Author(s)
  稲熊真悟、笠井謙次、米山亜紀子、池田洋
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2009-05-03
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] 膵臓癌およびPancreatic Intraepithelial Neoplasia(PanIN)におけるSIL発現状況の免疫組織学的解析2009
- Author(s)
  米山亜紀子、稲熊真悟、笠井謙次、池田洋
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2009-05-03
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] GLI1 enhances themotility and invasion by gel forming mucin MUC5AC up-regulation in pancreatic cancer cells2009
- Author(s)
  稲熊真悟、笠井謙次
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21590408
[Presentation] がん細胞において転写因子GLI1はbHLH型転写抑制因子DEC2、HES1の発現を直接誘導する2008
- Author(s)
  稲熊真悟、笠井謙次、池田洋
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590371
[Presentation] 膵臓癌におけるHedgehogシグナル系転写因子GLI1のSUFU依存性制御からの離脱機構2008
- Author(s)
  笠井謙次、稲熊真悟、米山亜紀子、池田洋
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢市
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19590371
[Presentation] SILによるGLI1のSUFU依存性制御からの離脱機構2008
- Author(s)
  笠井謙次、稲熊真悟、池田洋
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590371
[Presentation] 膵前癌病変におけるShh-GLI1標的遺伝子MUC5ACの発現解析2008
- Author(s)
  稲熊真悟、笠井謙次、米山亜紀子、池田洋
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢市
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19590371
[Presentation] ヘッジホッグ系転写因子GLI1はCXCL12/CXCR4経路の活性化により乳癌細胞の遊走能を亢進させる
- Author(s)
  稲熊真悟、笠井謙次、伊藤秀明、陸美穂、池田洋
- Organizer
  第104回日本病理学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-04-30 – 2015-05-02
- Data Source
  KAKENHI-PROJECT-24590456

1. IKEDA Hiroshi (00131219)

# of Collaborated Projects: 5 results

# of Collaborated Products: 23 results
2. INAGUMA Shingo (80410786)

# of Collaborated Projects: 5 results

# of Collaborated Products: 24 results
3. ITO Masafumi (50184693)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. ITO Hideaki (90711276)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. 森尚義 (90045732)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ASAI Junpei (40022793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUMI Yukiko (00022806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKAYAMA Atsushi (50227964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 猪子誠人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kasai Kenji 笠井 謙次

笠井 謙次 カサイ ケンジ

KASAI Kenji 笠井 謙次

Research Projects

Research Products

Co-Researchers

ENTREP-mediated modulation of PD-L1 ubiquitination and the tumor immunity.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cell cycle regulation of triple-negative breast cancer by newly-identified nuclear protein network.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Downstream of newly identified transcriptional repressor and its role in the progression of non-invasive breast cancer.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hedgehog signaling molecule SIL regulates the migration and progression of pancreatic ductal adenocarcinoma.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of SIX3 and SIL in the Hedgehog signaling during pancreatic carcinogenesis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of the Hedgehog signaling in invasion and metastasis of pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ホジキン病における免疫グロブリン超可変領域の遺伝子的検討

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

non-T ALLにおける免疫グロブリン入鎖高頻度発現の遺伝子的解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the structure of reticular framework and its micro-environment in the lymphoid

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Down-regulation of the zinc-finger homeobox protein TSHZ2 releases GLI1 from the nuclear repressor complex to restore its transcriptional activity during mammary tumorigenesis2015

Author(s)

Journal Title

DOI

Data Source

Kasai Kenji 笠井謙次

笠井謙次カサイケンジ

KASAI Kenji 笠井謙次