WADA Akihiro 和田昭裕

Researcher Number	70253698
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2023: 近畿大学, 医学部, 助教 2012: 長崎大学, 熱帯医学研究所, 講師 2003 – 2007: Nagasaki University, Institute of Tropical Medicine, Lecturer, 熱帯医学研究所, 講師 1994 – 2003: 長崎大学, 熱帯医学研究所, 助手
Review Section/Research Field	Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / Basic Section 50010:Tumor biology-related / Chemical biology Except Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / Bioproduction chemistry/Bioorganic chemistry
Keywords	Principal Investigator guanylyl cyclase / heat-stable enterotoxin / Nod1 / CagA / NF-κB / 病原性遺伝子群 / 抗体医薬 / CADM1 / 内在化抗体 / KRAS … More / GM1 / immune modulation / receptor / CT-B / cholera toxin / Bサブユニット / アジュバンド / 毒素 / コレラ / H.pylori / 炎症 / Cag / ヘリコバクター / OMV / アウターメンブランベシクル / 抗菌性ペプチド / ディフェンシン / ヘリコバクター・ピロリ / LPS / IL-8 / ヘリコバクターピロリ / 膜結合型グアニル酸シクラーゼ / 耐熱性エンテロトキシン受容体 / 耐熱性エンテロトキシン … More Except Principal Investigator 細菌毒素 / VacA / 毒性発現 / ヘリコバクター・ピロリ / 毒素受容体 / VacA毒素 / 空胞化毒素 / ヘリコバクター / bacterial toxin / レセプター / グアニル酸シクラーゼ / エンテロトキシン / 大腸菌 / 下痢毒素 / 腸管感染症 / COX-2 / Bacterial toxin / VacA toxin / vacuolating cytotoxin / toxin receptor / Helicobacter pylori / BACTERIAL INFECTION / 細菌感染症 / 病原因子 / Pathogenesis / ATF-2 cascade / p38 MAP kinase / PGE_2 / AZ-521 cells / ミトコンドリア障害 / Inhibitor of growth / Helicobacter Pyroli / cyclodextrin / 増殖阻害 / 増殖阻害物質 / ピロリ菌 / シクロデキストリン / Toxin comparison / diseases / Helicobocter pylori / ヘリコバクター・ピロリ感染症 / 多形比較 / 多様な疾患 / RPTP β / Toxicity / Vacuolating cytotoxin / Helicobacter / vaccine / toxicity / Helicobacier pylori / 病原遺伝子群 / ワクチン開発 / CagPAI / 成分ワクチン / ワクチン / differentiation of HL-60 cell / protein tyrosine phosphatase beta / cytotoxin / HL-60 / 結合部位 / 細胞毒素 / 細菌感染 / RPTPβ / 受容体 / 空胞化致死毒素 / GUANYLYL CYCLASE / TOXIN RECEPTOR / HEAT-STABEL ENTEROTOXIN / ENTEROTOXIGENIC ESCHERICHIA COLI / ENTEROTOXITY / 腸管感帯症 / 毒素原性大腸菌 / 耐熱性エンテロトキシン / 下痢原性発現 / ETIOLOGIC AGENT / BACTERIAL TOXIN / ADP-RIBOSYLTRANSFERASE / HELICOBACTER PYLORI / ADP-リボシル化酵素 Less

内在化する抗体による細胞内癌抗原標的創薬の基礎研究Principal Investigator
- Principal Investigator
  
  和田昭裕
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kindai University
Outer membrane vesicles (OMVs)mediated protection of E. coli against effects of human antimicrobial peptides.Principal Investigator
- Principal Investigator
  
  WADA Akihiro
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  Nagasaki University
Identification of cholera toxin B subunit binding protein and its bioactive analysisPrincipal Investigator
- Principal Investigator
  
  WADA Akihiro
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Study on the function of receptor for Helicobacter pylori VacA and the mechanism of its intoxication
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Mechanism of cag pathogenicity island-positive Helicobacter pylori mediated inflammatory reactionPrincipal Investigator
- Principal Investigator
  
  WADA Akihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Research for comparison of VacA in H. pylori infectious diseases
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Synthesis of novel cyclodextrin derivatives and its application to search for the inhibitor of H.pyroli growth
- Principal Investigator
  
  HOJO Hironobu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  TOKAI UNIVERSITY
ヘリコバクター・ピロリの病原性遺伝子群の機能解析Principal Investigator
- Principal Investigator
  
  和田昭裕
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
Basic research for H. pylori component vaccine
- Principal Investigator
  
  HITAYAMA Toshiya
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
TOXICITY OF HELICOBACTER PYLORI VACA TOXIN THROUGH ITS CELLULAR RECEPTOR
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  NAGASAKI UNIVERSITY
耐熱性エンテロトキシン受容体のグアニル酸シクラーゼ活性制御蛋白質Principal Investigator
- Principal Investigator
  
  和田昭裕
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
RECEPTOR OF HELICOBACTER PYLORI VACA TOXIN AND ITS SIGNAL FOR TOXIXITY
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  NAGASAKI UNIVERSITY
耐熱性エンテロトキシン受容体のC末端領域の機能Principal Investigator
- Principal Investigator
  
  和田昭裕
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
ADP-RIBOSYLTRANSFERASE OF HELIOBACTER PYLORI
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
ENTEROTOXICITY OF HEAT-STABLE ENTEROTOXIN PRODUCED FROM ENTEROTOXIGENIC ESCHERICHIA COLI
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  NAGASAKI UNIVERSITY
ヘリコバクターピロリのIL-8誘導因子についてPrincipal Investigator
- Principal Investigator
  
  和田昭裕
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
毒素原性大腸菌の耐熱性エンテロトキシンの受容体活性化
- Principal Investigator
  
  平山壽哉
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
耐熱性エンテロトキシン受容体の毒素結合に重要な部位の機能についてPrincipal Investigator
- Principal Investigator
  
  和田昭裕
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
毒素原性大腸菌の耐熱性下痢毒素の受容体活性化
- Principal Investigator
  
  HIRAYAMA Toshiya
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University
毒素原性大腸菌耐熱性下痢毒素の受容体結合部位とダイマー構造形成部位Principal Investigator
- Principal Investigator
  
  和田昭裕
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Nagasaki University

All 2023 2013 2012 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Potential Contribution of Cell Adhesion Molecule 1 to the Binding of SARS-CoV-2 Spike Protein to Mouse Nasal Mucosa.2023
- Author(s)
  Takeuchi F, Sugano A, Yoneshige A, Hagiyama M, Inoue T, Wada A, Takaoka Y, Ito A.
- Journal Title
  
  Cells Tissues Organs
  
  Volume: Online ahead of print. Issue: 4 Pages: 1-12
- DOI
  10.1159/000534892
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06494, KAKENHI-PROJECT-23K06682, KAKENHI-PROJECT-21K12110
[Journal Article] Alarin but not its alternative-splicing form, GALP (Galanin- like peptide) has antimicrobial activity.2013
- Author(s)
  A. Wada, Y. Kuboら
- Journal Title
  
  Biochemical and Biophysical Research Communication
  
  Volume: 434 Issue: 2 Pages: 223-227
- DOI
  10.1016/j.bbrc.2013.03.045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590416, KAKENHI-PROJECT-24510317, KAKENHI-PROJECT-24592432, KAKENHI-PROJECT-24651263
[Journal Article] Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial peptide2013
- Author(s)
  Wada A. et al.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 434 Pages: 223-227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24651263
[Journal Article] Oncogenesis and the link between inflammation and cancer due to human papillomavirus(HPV)infection,and the development of vaccine control strategies2008
- Author(s)
  Senba M., Mori N., Wada A.
- Journal Title
  
  Cancer Research Joumal (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590430
[Journal Article] Oncogenesis and the link between inflammation and cancer due to human papillomavirus(HPV) infection, and the development of vaccine control strategies2008
- Author(s)
  M., Senba, N., Mori, A., Wada
- Journal Title
  
  Cancer Research Journal (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590430
[Journal Article] Oncogenesis and the link between inflammation and cancer due to human papillomavirus (HPV) infection, and the development of vaccine control strategies2008
- Author(s)
  Senba M., Mori N., and Wada A.
- Journal Title
  
  Cancer Research Journal (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590430
[Journal Article] 燐タングステン酸およびモリブデン酸アンモニウムによるグラム陰性菌のネガティブ染色法の改良2007
- Author(s)
  一ノ瀬昭豊、和田昭裕
- Journal Title
  
  医生電顕技術誌 21(1)
  
  Pages: 1-6
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590430
[Journal Article] Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic protein Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation.2006
- Author(s)
  Yamasaki E, Wada A, Kumatori A, Nakagawa I, Funao J, Nakayama M, Hisatsune J, Kimura M, Moss J, Hirayama T
- Journal Title
  
  J Biol Chem. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590364
[Journal Article] Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteirs Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation2006
- Author(s)
  E., Yamasaki, A., Wada, A., Kumatori, I., Nakagawa, J., Funao, M., Nakayama, J., Hisatsune, M., Kimura, J., Moss, T., Hirayama
- Journal Title
  
  J Biol Chem 281(16)
  
  Pages: 11250-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590430
[Journal Article] Helicobacter pylori VacA clustering in lipid rafts, mediated by receptor, RPTP β, is required for intoxication in AZ-521 cells.2006
- Author(s)
  Nakayama M, Hisatsune J, Yamasaki E, Nishi Y, Wada A, Kurazono H, Sap J, Yahiro K, Moss J, Hirayama T
- Journal Title
  
  Infect Immun 74
  
  Pages: 6571-6580
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209015
[Journal Article] Endoscope disinfection using chlorine dioxide in an automated washer-disinfector2006
- Author(s)
  H., Isomoto, M., Urata, K., Kawazoe, J., Matsuda, Y., Nishi, A., Wada, K., Ohnita, Y., Hirakata, N., Matsuo, K., Inoue, T., Hirayama, S., Kamihira, S., Kohno
- Journal Title
  
  J Hosp Infect 63(3)
  
  Pages: 298-305
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590430
[Journal Article] Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic protein Bax, leading to cytochrome c release and cell death, independent of vacuolation2006
- Author(s)
  Yamasaki E., Wada A., Kumatori A., Nakagawa I., Funao J., Nakayama M., Hisatsune J., Kimura M., Moss J., Hirayama T.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 11250-11259
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209015
[Journal Article] Endoscope disinfection using chlorine dioxide in an automated washer-disinfector.2006
- Author(s)
  Isomoto H., Urata M, Kawazoe K, Matsuda J, Nishi Y, Wada A, Ohnita K, Hirakata Y, Matsuo N, Inoue K, Hirayama T, Kamihira S, Kohno S.
- Journal Title
  
  J. Hosp. Infect 63
  
  Pages: 298-305
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209015
[Journal Article] Helicobacter pylori vacoulating cytotoxin induces activation of the proapoptoic proteins Bax and Bak,leading to cytochrome c release and cell death,independent of vacuolation2006
- Author(s)
  Yamasaki, E., Wada, A., et. al.
- Journal Title
  
  J Biol Chem. 281(16)
  
  Pages: 11250-11259
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590430
[Journal Article] Clustering of Helicobacter pylori VacA in lipid rafts, mediated by its receptor, receptor-like protein tyrosine phosphatase beta, is required for intoxication in AZ-521 Cells2006
- Author(s)
  M., Nakayama, J., Hisatsune, E., Yamasaki, Y., Nishi, A., Wada, H., Kurazono, J., Sap, K., Yahir, J., Moss, T., Hirayama
- Journal Title
  
  Infect Immun 74(12)
  
  Pages: 6571-80
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590430
[Journal Article] High concentrations of human beta-defensin 2 in gastric juice of patients with Helicobacter pylori infection.2005
- Author(s)
  Isomoto H, Mukae H, Ishimoto H, Nishi Y, Wen CY, Wada A, Ohnita K, Hirayama T, Nakazato M, Kohno S.
- Journal Title
  
  World J Gastroenterol 11(31)
  
  Pages: 4782-4787
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590364
[Journal Article] Cytotoxicity and recognition of receptor-like protein tyrosine phosphatases, RPTPalpha and RPTPbeta, by Helicobacter pylori m2VacA.2005
- Author(s)
  De Guzman BB, Hisatsune J, Nakayama M, Yahiro K, Wada A, Yamasaki E, Nishi Y, Yamazaki S, Azuma T, Ito Y, Ohtani M, van der Wijk T, den Hertog J, Moss J, Hirayama T.
- Journal Title
  
  Cell Microbiol. 7(9)
  
  Pages: 1285-1293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590364
[Journal Article] Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells.2005
- Author(s)
  Yokoyama K, Higashi H, Ishikawa S, Fujii Y, Kondo S, Kato H, Azuma T, Wada A, Hirayama T, Aburatani H, Hatakeyama M.
- Journal Title
  
  Proc Natl Acad Sci U S A. 102(27)
  
  Pages: 9661-9666
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590364
[Journal Article] Helicobacter pylori vacuolating cytotoxin, VacA, is responsible for gastric ulceration.2004
- Author(s)
  Wada A.et al.
- Journal Title
  
  J Biochem 136(6)
  
  Pages: 741-746
- NAID
  10016203994
- Data Source
  KAKENHI-PROJECT-16590364
[Presentation] 摂食亢進ペプチドAlarinの新規な生物活性2012
- Author(s)
  和田昭裕ら
- Organizer
  日本熱帯医学会
- Place of Presentation
  帯広市, とかちプラザ, 北海道
- Data Source
  KAKENHI-PROJECT-24651263
[Presentation] 摂食亢進ペプチドAlarinの新規な生物活性2012
- Author(s)
  和田昭裕ら
- Organizer
  日本熱帯医学会
- Place of Presentation
  帯広
- Data Source
  KAKENHI-PROJECT-24651263
[Presentation] コレラ毒素Bサブユニットが示す生物活性の解析2008
- Author(s)
  和田昭裕, ら
- Organizer
  第81回日本細菌学会
- Place of Presentation
  京都
- Year and Date
  2008-03-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590430

1. HIRAYAMA Toshiya (50050696)

# of Collaborated Projects: 9 results

# of Collaborated Products: 3 results
2. AOYAMA Nobuo (30243299)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. NODA Masatoshi (60164703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. MAKINO Souichi (30181621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. YAHIRO Kinnosuke (80345024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KURAZONO Hisao (90186487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HOJO Hironobu (00209214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MOSS Joel

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIRASAKA Daisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 久保嘉直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 萩山満

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

WADA Akihiro 和田 昭裕

Research Projects

Research Products

Co-Researchers

内在化する抗体による細胞内癌抗原標的創薬の基礎研究Principal Investigator

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Outer membrane vesicles (OMVs)mediated protection of E. coli against effects of human antimicrobial peptides.Principal Investigator

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Identification of cholera toxin B subunit binding protein and its bioactive analysisPrincipal Investigator

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Mechanism of cag pathogenicity island-positive Helicobacter pylori mediated inflammatory reactionPrincipal Investigator

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ヘリコバクター・ピロリの病原性遺伝子群の機能解析Principal Investigator

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耐熱性エンテロトキシン受容体のグアニル酸シクラーゼ活性制御蛋白質Principal Investigator

Principal Investigator

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Principal Investigator

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耐熱性エンテロトキシン受容体のC末端領域の機能Principal Investigator

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Principal Investigator

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WADA Akihiro 和田昭裕