OHE Tohru 大江透

Researcher Number	70263556
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External Links
Affiliation (based on the past Project Information) *help	2009: 岡山大学, 大学院・医歯薬学総合研究科, 教授 2006 – 2007: 岡山大学, 医歯(薬)学総合研究科, 教授 2005 – 2007: 岡山大学, 大学院・医歯薬学総合研究科, 教授 2005 – 2006: 岡山大学, 大学院医歯薬学総合研究科, 教授 2001 – 2004: 岡山大学, 大学院・医歯学総合研究科, 教授 1997 – 2000: 岡山大学, 医学部, 教授
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Biomedical engineering/Biological material science / Circulatory organs internal medicine / Biomedical engineering/Biological material science
Keywords	Principal Investigator QT延長症候群 / K channel / dispersion / ethanol / repolarization / Long QT syndrome / Brugada Syndrome / チャンネル / KvLQT1遺伝子 / Brugada症候群 … More / QT alternans / チャネル / 特発性心室細動 / Kチャンネル / ばらつき / エタノール / 再分極 / Brugada症候詳 / gene diagnosis / electrocardiogram / long QT Syndrome / 遺伝子診断 / 心電図 … More Except Principal Investigator 心不全 / SPring-8 / β遮断薬 / 酸化ストレス / QT延長症候群 / tissue repair / cytokine / progenitor cell / apoptosis / gene therapy / myocardial ischemia / angiogenesis / sonic hedgehog / 心筋再生 / Sonic Hedgehog / 再生医療 / 組織修復 / サイトカイン / 幹細胞 / アポトーシス / 遺伝子治療 / 心筋虚血 / 血管新生 / sonic Hedgehog / cardiac output / pulmonary vascular smooth muscle / liposome / oxygen affinity / vascular resistance / right ventricular dysfunction / oxygen carrier / pulmonary hypertension / ヘモグロビン / 肺動脈抵抗 / 人工赤血球 / 心拍出量 / 肺動脈血管平滑筋 / リポソーム / 酸素親和度 / 血管抵抗 / 右心不全 / 酸素運搬体 / 原発性肺高血圧症 / Vascular regUlation / Transmural characteristics / Intravital CCD / Crossbridge Dynamics / Cardiac Contraction / Coronary Circulation / Physiome / 3D-microCT / 心筋クロスブリッジ / 筋線維 / 冠循環 / 放射光 / 拍動心臓 / 培養心筋細胞 / ミオシン / アクチン / 容量血管 / 3次元解析 / 毛細血管可視化 / 冠微小血管 / マクロモレキュール / 心筋線維配向 / X線回折像解析 / アクチン・ミオシン / 分子トレーサー / 心筋内灌流分布 / 冠微小血管造影 / X線回折 / ミオシン格子 / 筋節構造 / クロスブリッジ動態 / 貫壁性 / 血流速度 / 冠微小循環 / Atrial fibrillation / Brugada syndrome / action potentials / T wave / extrasystoles / Early afterdepolarization / I(Kr) / QT intervals / 活動電位持続時間 / 交感神経 / 遅延整流カリウム電流 / 動脈灌流左室心筋切片 / 拡張型心筋症 / 伝導遅延 / 有効不応期 / Brugada症候群型 / 不全心 / 内向き整流Kチャンネル / アルデヒド / 低カリウム血症 / 潜在性QT延長 / 先天性QT延長 / 後天性QT延長 / 心房細動 / Brugada症候群 / 活動電位 / T波 / 期外収縮 / 早期後脱分極 / Ikr / QT間隔 / Ca exchanger / Na / 心筋症 / 4-Hydroxy-2-nonenal(HNE) / マクロファージ / 抗酸化酵素 / 電子スピン共鳴法 / 不整脈発生 / 心筋内カルシウム濃度 / SCN5A遺伝子 / Brugda症候群 / NADPH oxidase / カルシウム / 活性酸素 / 4-Hydroxy-2-nonenAL(HNE) / Ca2+交換体 / Na+ / 大動脈結窄モデル / Ca2+オーバーロード / 心機能 / 心筋細胞 / NO産生 / トランスポーター / チャネル / 心血管細胞の機械受容機構 / Ca2+ハンドリング / 血行動態負荷 / チャネル・トランスポーター / Ca2+輸送体 / トランスレーショナルリサーチ / Ca^<2+>ハンドリング / メカノセンサー / 心肥大 / カルシウムチャネル / エストロゲン / プロゲステロン / 性差 / カベオラ / リン酸化 / カリウムチャネル / タンパク間相互作用 / カルモデュリン / レドックス / 不整脈 / ニトロシル化 / 酸化修飾 / 一酸化窒素 / 性差医療 / 性ホルモン / 細胞移植 / Cell Cycle / 不死化 / SV40T / 心筋細胞株 / Creリコンビナーゼ / ペースメーカー / 可逆性不死化システム Less

The role of mechanosensor on cardiovascular disease.
- Principal Investigator
  
  NARUSE Keiji
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Okayama University
gp91phox遺伝子に対するsiRNAを用いた心不全に伴う心室性不整脈の治療
- Principal Investigator
  
  中村一文
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Okayama University
性ホルモンによる心筋イオンチャネル制御の検討-不整脈の性差医療の基礎戦略
- Principal Investigator
  
  FURUKAWA Tetsushi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
Investigation of vascular resistance reducing therapy for primary pulmonary hypertension: replacement of RBC with nano-order liposomal hemoglobin
- Principal Investigator
  
  MOHRI Satoshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Okayama University
Sonic hedgehog gene therapy in myocardial ischemia
- Principal Investigator
  
  KUSANO Kengo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Okayama University
可逆性不死化培養心筋細胞を用いたペースメーカー細胞の再生
- Principal Investigator
  
  NAKAMURA Kazufumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Okayama University
The Mechanism of Ventricular Repolarization Abnormality and Acquired Long QT Syndrome in Chronic Heart Failure.
- Principal Investigator
  
  EMORI Tetsuro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  OKAYAMA UNIVERSITY
Analysis of coronary microcirculation and myocardial crossbridge dynamic using SPring-8 synchrotron facility
- Principal Investigator
  
  KAJIYA Fumihiko
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Okayama University
The investigation of pathogenesis and gene abnormality in heart disease caused by disorder of ion channelPrincipal Investigator
- Principal Investigator
  
  OHE Tohru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  OKAYAMA University
Multiple mechanisms in the long-QT Syndrome.Principal Investigator
- Principal Investigator
  
  OHE Tohru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  OKAYAMA Universty

All 2008 2007 2006 Other

All Journal Article

[Journal Article] 心不全患者の不整脈をどう治療するか2008
- Author(s)
  大江透, 中村一文, 他
- Journal Title
  
  不整脈News & Views No. 26
  
  Pages: 3-9
- Data Source
  KAKENHI-PROJECT-19659205
[Journal Article] Anti-KCNH2 antibody-induced long QT syndrome. Novel acquired form of LQT syndrome2007
- Author(s)
  Nakamura K, Katayama Y, Kusano K, Haraoka K, Tani Y, Nagase S, Morita H, Miura S, Fujimoto Y, Furukawa T, Ueda K, Aizawa Y, Kimura A, Kurachi Y, Ohe T
- Journal Title
  
  J.Am.Coll.Cardiol 50
  
  Pages: 1808-1809
- Data Source
  KAKENHI-PROJECT-18390231
[Journal Article] Impaired NO-mediatevasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats.2007
- Author(s)
  Kajiya M, Hirota M, Inai Y, Kiyooka T, Morimoto T, Iwasaki T, Endo K, Mohri S, Shimizu J, Yada T, Ogasawara Y, Naruse K, Ohe T, Kajiya F
- Journal Title
  
  Am J Physiol Heart Circ Physiol 292(6)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19200037
[Journal Article] Anti-KCNH2 antibody-induced long QT syndrome? Novel acquired form of LQT syndrome?2007
- Author(s)
  Nakamura K, Katayama Y, Kusano K, Haraoka K, Tani Y, Nagase S, Moritsa H, Miura D, Fujimoto Y, Furukawa T, Ueda K, Aizawa Y, Kimura A, Kurachi Y, Ohe T.
- Journal Title
  
  J. Amer. Coll. Cardiol. 50
  
  Pages: 1808-1809
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390231
[Journal Article] 血管新生因子 Shh。2006
- Author(s)
  草野研吾, 大江透
- Journal Title
  
  J Jpn Coll Angiol 46
  
  Pages: 311-316
- NAID
  10020298315
- Data Source
  KAKENHI-PROJECT-17590736
[Journal Article] 血管新生因子 Shh2006
- Author(s)
  草野研吾, 大江透
- Journal Title
  
  J Jpn Coll Angiol 46
  
  Pages: 311-316
- NAID
  10020298315
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590736
[Journal Article] Impaired NO-mediated vasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats.
- Author(s)
  Kajiya M, Hirota M, Inai Y, Kiyooka T, Morimoto T, Iwasaki T, Endo K, Mohri S, Shimizu J, Yada T, Ogasawara Y, Naruse K, Ohe T, Kajiya F
- Journal Title
  
  Am J Physiol Heart Circ Physiol. (In press)
- Data Source
  KAKENHI-PROJECT-17390230

1. NAKAMURA Kazufumi (10335630)

# of Collaborated Projects: 7 results

# of Collaborated Products: 1 results
2. KUSANO Kengo (60314689)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
3. SHIMIZU Jyuichiro (80294403)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. MORI Satoshi (00294413)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. KAJIYA Fumihiko (70029114)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
6. FURUKAWA Tetsushi (80251552)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. IRIBE Gentaro (90284885)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. EMORI Tetsuro (20273964)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 中谷晴昭 (60113594)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 柳圭子 (70265990)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. NARUSE Keiji (40252233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. MATSUI Hideki (30157234)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TOMIZAWA Kazuhito (40274287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KATANOSAKA Yuki (60432639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MORITA Hiroshi (50322227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YAMANARI Hiroshi (00240060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. SUGA Hiroyuki (90014117)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. YAGI Naoto (80133940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ASAHARA Takayuki (20246200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 小林直哉 (10325102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 黒川洵子 (40396982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 荒木淳一 (80271055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 伊達洋至 (60252962)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHE Tohru 大江 透

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The investigation of pathogenesis and gene abnormality in heart disease caused by disorder of ion channelPrincipal Investigator

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Multiple mechanisms in the long-QT Syndrome.Principal Investigator

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[Journal Article] 心不全患者の不整脈をどう治療するか2008

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[Journal Article] Anti-KCNH2 antibody-induced long QT syndrome. Novel acquired form of LQT syndrome2007

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[Journal Article] Impaired NO-mediatevasodilation with increased superoxide but robust EDHF function in right ventricular arterial microvessels of pulmonary hypertensive rats.2007

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[Journal Article] Anti-KCNH2 antibody-induced long QT syndrome? Novel acquired form of LQT syndrome?2007

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[Journal Article] 血管新生因子 Shh。2006

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NAID

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[Journal Article] 血管新生因子 Shh2006

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OHE Tohru 大江透