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Harada-Shiba Mariko  斯波 真理子

ORCIDConnect your ORCID iD *help
… Alternative Names

斯波 真理子  シバ マリコ

HARADA-SHIBA Mariko  斯波 真理子

SHIBA Mariko  斯波 真理子

SEHIBA Mariko  斯波 真理子

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Researcher Number 70271575
Other IDs
External Links
Affiliation (Current) 2025: 大阪医科薬科大学, 医学部, 特別職務担当教員(教授)
Affiliation (based on the past Project Information) *help 2023: 大阪医科薬科大学, 医学部, 特別職務担当教員(教授)
2020 – 2021: 国立研究開発法人国立循環器病研究センター, 研究所, 非常勤研究員
2019: 国立研究開発法人国立循環器病研究センター, 研究所, 部長
2017: 国立循環器病研究センター, 研究所, 部長
2013: 独立行政法人国立循環器病研究センター, その他部局等, その他 … More
2012: 独立行政法人国立循環器病研究センター, 研究所, 部長
2011: 独立行政法人国立循環器病研究センター, 病態代謝部, 特任部長
2010: 独立行政法人国立循環器病研究センター, 分子薬理部, 室長
2009: 国立循環器病センター研究所, バイオサイエンス部, 室長
2003 – 2004: 国立循環器病センター研究所, 室長(研究職)
2003 – 2004: 国立循環器病センター研究所, バイオサイエンス部, 室長
2002: 国立循環器病センター, 研究所, 室長(研究職)
1999 – 2001: 国立循環器病センター研究所, 循環動態機能部, 室員
1995 – 1996: 国立循環器病センター研究所, 循環動態機能部, 室員 Less
Review Section/Research Field
Principal Investigator
Metabolomics / Basic Section 47060:Clinical pharmacy-related / 内分泌・代謝学
Except Principal Investigator
Circulatory organs internal medicine / Basic Section 55030:Cardiovascular surgery-related / Basic Section 53020:Cardiology-related / Basic Section 37010:Bio-related chemistry / Cardiovascular medicine / Biomedical engineering/Biological material science / Circulatory organs internal medicine / Biomedical engineering/Biological material science
Keywords
Principal Investigator
PEG-DET / 遺伝子治療 / THP-1細胞 / コレステロール / マクロファージ / 動脈硬化 / 安全性 / アンチセンス / 経口投与 / DDS … More / 家族性高コレステロール血症 / 核酸医薬 / Polymerization / Atherosclerosis lesion selective / Polymer vector / in vivo gene transfer / Intra tracheal gene transfer / Nano-particle / Gene therapy / 血管内皮細胞 / 血中安定性 / SS結合 / 遺伝子導入ベクター / 重合度 / 動脈硬化巣選択的 / ポリマーベクター / in vivo遺伝子導入 / 気管内投与 / 高分子ナノ微粒子 / POLY-L-LYSINE / LIVER / CATIONIC POLYMER / HEP G2 CELL / PIC MICELLES / BLOCK COPOLYMER / NON-VIRAL VECTOR / GENE THERAPY / DNAコンプレックス / DNA / ポリマー / ポリLリジン / 肝臓 / カチオニックポリマー / HepG2細胞 / PICミセル / 共重合体 / non-viralベクター / Transforming growth factor-beta1 / Scavenger receptor / Macrophage / Low-density lipoprotein / Cholesterol / Atherosclerosis / Apolipoprotein / 泡沫化 / PAI-1 / TGF-β1 / サイトカイン / TGF-β / スカベンジャー受容体 / LDL / アポリポ蛋白 / アポEノックアウトマウス / 動脈硬化症硬 / ニューロメジンU / 脂質異常症 / モデル動物 / ニューロメジンU … More
Except Principal Investigator
家族性高コレステロール血症 / 核酸医薬 / DNA / アンチセンス医薬 / 組織標的ペプチド / 心筋保護治療 / 糖鎖リガンド / ドラッグデリバリー / ゲノム編集治療 / 表面受容体 / 脂質異常症 / オリゴヌクレオチド / 糖リガンド / アシアロ糖タンパク質 / CRISPR/Cas / ドラッグデリバリーシステム / 遺伝子編集技術 / ゲノム編集技術 / DDS / 核酸 / CRISPR/Cas9 / ゲノム編集 / ApoB / プロドラッグ型RNA / 還元環境に応答する / Apolipoprotein B / ホモ接合体家族性高コレステロール血症 / 還元環境応答型 / プロドラッグ型核酸 / 還元環境 / プロドラッグ型 / siRNA / 粒子組成 / HDL粒子組成 / HDLの質 / 抗酸化能 / コレステロール引き抜き能 / 一般住民コホート / HDLコレステロール / HDL機能 / polyethylene glycol / Biocompartibility / nanocapsul / block copolymer / gene delivery / polymeric micelle / ポリエチレングリコール / 生体適合性 / ナノカプセル / ブロック共重合体 / 遺伝子デリバリー / 高分子ミセル / phosphatidylinositol 3-kinase / Signal Transduction, / Inhibitors. / PDGF, / Inositol lipid / Chemotaxis, / Vascular Smooth Muscle Cells, / phosphatidylinositol 3-Kinase / Phosphatidylinositol 3-kinase / phosphatidylinositol 3-kinas / 細胞内情報伝達 / 阻害剤 / PDGF / イノシトールリン脂質 / ケモタキシス / 血管平滑筋 / ABCA1 / HDL / アフェレーシス / 病因物質 / DNCS / メタボリックスイッチング / 自己免疫疾患 / 高脂血症 / 徐放 / 血管新生因子 / 下肢虚血モデル / 虚血性疾患 / ゼラチンハイドロゲル / 狭心症 / 心筋梗塞 / 閉塞性動脈硬化症 / 微小循環 / 血管成長因子 / 再生医療 / 血管新生 / 遺伝子治療 Less
  • Research Projects

    (14 results)
  • Research Products

    (78 results)
  • Co-Researchers

    (29 People)
  •  虚血心筋標的ペプチドを用いたアンチセンス医薬による心筋保護治療の開発

    • Principal Investigator
      神吉 佐智子
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Osaka Medical and Pharmaceutical University
  •  Design of siRNA-based prodrug-type therapeutics for familial hypercholesterolemia

    • Principal Investigator
      Urata Hidehito
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37010:Bio-related chemistry
    • Research Institution
      Osaka Medical and Pharmaceutical University
      Osaka University of Pharmaceutical Sciences
  •  Establishment of a new platform for nucleic acid oral formulation technology to realize patient-friendly nucleic acid medicinesPrincipal Investigator

    • Principal Investigator
      Harada-Shiba Mariko
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Development of drug delivery system for CRISPR/Cas9 for the treatment of familial hypercholesterolemia

    • Principal Investigator
      Yamamoto Tsuyoshi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Nagasaki University
  •  Is HDL quality a good candidate for novel therapeutic target of cardiovascular disease?

    • Principal Investigator
      Ogura Masatsune
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Development of increasing functional HDL-C using antisense oligonucleotides as innovative therapy

    • Principal Investigator
      IWAMOTO Noriyuki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Elucidation of the roles of Neuromedin U on development of atherosclerosis and its therapeutic applicationPrincipal Investigator

    • Principal Investigator
      SHIBA Mariko
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      National Cardiovascular Center Research Institute
  •  病因物質を体内から除去する新たな戦略:メタボリックスイッチング

    • Principal Investigator
      山岡 哲二
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Development of the vectors for atherosclerosis lesion specific gene delivery using polyion compex micellesPrincipal Investigator

    • Principal Investigator
      SHIBA Mariko
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Creation of intelligent polymeric micelle nanocapsuls for gene delivery

    • Principal Investigator
      KATAOKA Kazunori
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      The University of Tokyo
  •  血管新生因子発現遺伝子の徐放による虚血組織の再生

    • Principal Investigator
      盛 英三
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  DEVELOPMENT OF THE METHOD OF GENE DELIVERY USING BLOCK COPOLYMER FOR THE TREATMENT OF CARDIOVASCULAR DISEASESPrincipal Investigator

    • Principal Investigator
      SEHIBA Mariko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Institution
      NATIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE
  •  Role of phosphatidylinositol 3-kinase in vascular remodeling

    • Principal Investigator
      SHIMOKADO Kentaro
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Studies on the regulation of cholesteryl ester synthesis and mechanism of lipid accumulation in macrophage cellsPrincipal Investigator

    • Principal Investigator
      YAMAMURA Taku, 斯波 真理子
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      National Cardiovascular Center Research Institute

All 2022 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 2010 2005 2004 2003

All Journal Article Presentation Book Patent

  • [Book] Inhibition of Tumor Growth and Metastasis by a Combination of Anti-VEGF-C and Enhanced IL-12 Therapy in an Immunocompetent Mouse Mammary Cancer Model2011

    • Author(s)
      Shibata M
    • Publisher
      In Tech
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Book] Intratracheal Gene Transfer Using Polyplex Nanomicelles and Their Application to Cardiology, Nanomedicine and the Cardiovascular System, edited by Ross J.Hunter,Victor R. Preedy, Nanomedicine and the Cardiovascular System2011

    • Author(s)
      Iwamoto N, Harada-Shiba M
    • Publisher
      Science Publishers
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Book] Non-viral gene therapy2005

    • Author(s)
      Mariko Harada-Shiba
    • Total Pages
      487
    • Publisher
      Springer-Verlag Tokyo
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590964
  • [Book] Non-viral gene therapy2005

    • Author(s)
      Harada-Shiba
    • Publisher
      Gene transfer and target diseases (in press)
    • Data Source
      KAKENHI-PROJECT-15590964
  • [Journal Article] Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides2021

    • Author(s)
      Yamamoto Tsuyoshi、Mukai Yahiro、Wada Fumito、Terada Chisato、Kayaba Yukina、Oh Kaho、Yamayoshi Asako、Obika Satoshi、Harada-Shiba Mariko
    • Journal Title

      Pharmaceutics

      Volume: 13 Issue: 6 Pages: 817-817

    • DOI

      10.3390/pharmaceutics13060817

    • NAID

      120007168845

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656
  • [Journal Article] Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides2021

    • Author(s)
      Wada Fumito、Yamamoto Tsuyoshi、Kobayashi Tadayuki、Tachibana Keisuke、Ito Kosuke Ramon、Hamasaki Mayumi、Kayaba Yukina、Terada Chisato、Yamayoshi Asako、Obika Satoshi、Harada-Shiba Mariko
    • Journal Title

      Molecular Therapy - Nucleic Acids

      Volume: 26 Pages: 957-969

    • DOI

      10.1016/j.omtn.2021.10.008

    • Data Source
      KAKENHI-PROJECT-19H03393
  • [Journal Article] Programmed Instability of Ligand Conjugation Manifold for Efficient Hepatocyte Delivery of Therapeutic Oligonucleotides2021

    • Author(s)
      Terada Chisato、Wada Fumito、Uchida Mei、Yasutomi Yukari、Oh Kaho、Kawamoto Seiya、Kayaba Yukina、Yamayoshi Asako、Harada-Shiba Mariko、Obika Satoshi、Yamamoto Tsuyoshi
    • Journal Title

      Nucleic Acid Therapeutics

      Volume: 31 Issue: 6 Pages: 404-416

    • DOI

      10.1089/nat.2021.0036

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-20H05874, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656
  • [Journal Article] Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides2019

    • Author(s)
      Yamamoto Tsuyoshi、Sawamura Motoki、Terada Chisato、Kashiwada Koki、Wada Fumito、Yamayoshi Asako、Obika Satoshi、Harada-Shiba Mariko
    • Journal Title

      Nucleosides, Nucleotides and Nucleic Acids

      Volume: 39 Issue: 1-3 Pages: 1-10

    • DOI

      10.1080/15257770.2019.1677911

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02087, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656, KAKENHI-PROJECT-18K14363
  • [Journal Article] Synthesis of Monovalent N ‐Acetylgalactosamine Phosphoramidite for Liver‐Targeting Oligonucleotides2019

    • Author(s)
      Yamamoto Tsuyoshi、Terada Chisato、Kashiwada Koki、Yamayoshi Asako、Harada‐Shiba Mariko、Obika Satoshi
    • Journal Title

      Current Protocols in Nucleic Acid Chemistry

      Volume: 78 Issue: 1 Pages: 1-18

    • DOI

      10.1002/cpnc.99

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02087, KAKENHI-PROJECT-19H03393, KAKENHI-PROJECT-19H03656
  • [Journal Article] Serum FABP5 concentration is a potential biomarker for residual risk of atherosclerosis in relation to cholesterol efflux from macrophages.2017

    • Author(s)
      Furuhashi M, Ogura M, Matsumoto M, Yuda S, Muranaka A, Kawamukai M, Omori A, Tanaka M, Moniwa N, Ohnishi H, Saitoh S, Harada-Shiba M, Shimamoto K, Miura T.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 217-217

    • DOI

      10.1038/s41598-017-00177-w

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461384, KAKENHI-PROJECT-15K09130, KAKENHI-PROJECT-16K09621, KAKENHI-PROJECT-17K09594
  • [Journal Article] VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body.2017

    • Author(s)
      Yamamoto H, Takada T, Yamanashi Y, Ogura M, Masuo Y, Harada-Shiba M, Suzuki H
    • Journal Title

      Scientific Reports

      Volume: 7 (1) Issue: 1 Pages: 633-633

    • DOI

      10.1038/s41598-017-00685-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K14996, KAKENHI-PROJECT-16K15155, KAKENHI-PROJECT-16H06219, KAKENHI-PROJECT-15K09130
  • [Journal Article] HDL機能と心血管疾患-FH患者からの知見-2016

    • Author(s)
      小倉正恒, 斯波真理子
    • Journal Title

      循環plus

      Volume: 17 Pages: 7-9

    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Journal Article] Association between Cholesterol Efflux Capacity and Atherosclerotic Cardiovascular Disease in Patients with Familial Hypercholesterolemia2016

    • Author(s)
      Masatsune Ogura, Mika Hori, Mariko Harada-Shiba.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 36(1) Issue: 1 Pages: 181-188

    • DOI

      10.1161/atvbaha.115.306665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09130, KAKENHI-PROJECT-15K19038
  • [Journal Article] リスクファクターコントロール:脂質代謝異常-さらなるLDL-Cの低下とHDLへの介入2016

    • Author(s)
      小倉正恒, 斯波真理子
    • Journal Title

      医学のあゆみ

      Volume: 256 Pages: 689-694

    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Journal Article] 家族性高コレステロール血症をめぐる最近の話題(小児を含む)2016

    • Author(s)
      小倉正恒, 斯波真理子
    • Journal Title

      Total Vascular Management

      Volume: 3 Pages: 18-22

    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Journal Article] FH診療の展望と課題2016

    • Author(s)
      小倉正恒, 斯波真理子
    • Journal Title

      呼吸と循環

      Volume: 64 Pages: 1095-1101

    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Journal Article] FH診療-これからの展望と課題2016

    • Author(s)
      小倉正恒, 斯波真理子
    • Journal Title

      BIO Clinica

      Volume: 13 Pages: 23-27

    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Journal Article] Defining patients at extremely high risk for coronary artery disease in heterozygous familial hypercholesterolemia.2012

    • Author(s)
      Sugisawa T, Okamura T, Makino H, Watanabe M, Kishimoto I, Miyamoto Y, Iwamoto N, Yamamoto A, Yokoyama S, Harada-Shiba M
    • Journal Title

      J Atheroscler Thromb

      Volume: 19(4) Pages: 369-375

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Journal Article] Guidelines for the management of familial hypercholesterolemia2012

    • Author(s)
      Harada-Shiba M
    • Journal Title

      J Atheroscler Thromb

      Volume: 19(12) Pages: 1043-1060

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Journal Article] Multicenter study to determine the diagnosis criteria of heterozygous familial hypercholesterolemia in Japan2012

    • Author(s)
      Harada-Shiba M, Arai H, Okamura T, Yokote K, Oikawa S, Nohara A, Okada T, Ohta T, Bujo H, Watanabe M, Wakatsuki A, Yamashita S
    • Journal Title

      J Atheroscler Thromb

      Volume: 19(11) Pages: 1019-1026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Journal Article] Mammary cancer gene therapy targeting lymphangiogenesis:VEGF-C siRNA and soluble VEGF receptor-s, a splicing variant2012

    • Author(s)
      Shibata M-A
    • Journal Title

      Med Mol Morphlo

      Volume: 45 Issue: 4 Pages: 179-184

    • DOI

      10.1007/s00795-012-0576-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Journal Article] Impact of statin treatment on the clinical fate of heterozygous familial hypercholesterolemia.2010

    • Author(s)
      Harada-Shiba M
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: VOL.17,7 Pages: 667-674

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Journal Article] Liver-targeted siRNA delivery by polyethylenimine (PEI)-pullulan carrier2010

    • Author(s)
      Jeong-Hun Kang, Yoichi Tachibana, Wakako Kamata, Atsushi Mahara, Mariko Harada-Shiba, Tetsuji Yamaoka
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 18 Pages: 3946-3950

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21650123
  • [Journal Article] Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo2004

    • Author(s)
      Mariko Harada-Shiba, Atsuko Takagi, et al.
    • Journal Title

      Circ.Res 95, 9

      Pages: 945-952

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590964
  • [Journal Article] Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo2004

    • Author(s)
      Harada-Shiba M, Takagi A, et al.
    • Journal Title

      Circulation Research 95・9

      Pages: 945-952

    • Data Source
      KAKENHI-PROJECT-15590964
  • [Journal Article] Disruption of autosornal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo2004

    • Author(s)
      Mariko Harada-Shiba, Atsuko Takagi, et al.
    • Journal Title

      Circ.Res 95

      Pages: 945-952

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590964
  • [Journal Article] Clinical features and genetic analysis of autosomal recessive hypercholesterolemia2003

    • Author(s)
      Mariko Harada-Shiba, Atsuko Takagi, et al.
    • Journal Title

      J Clin Endocrinol Metab 88

      Pages: 2541-2547

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590964
  • [Journal Article] Long-term effect of low-density lipoprotein apheresis inpatients with homozygous familial hypercholesterolemia2003

    • Author(s)
      Hisashi Makino, Mariko Harada-Shiba
    • Journal Title

      Therap Apher Dial 7

      Pages: 397-401

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590964
  • [Journal Article] Clinical features and genetic analysis of autosomalrecessive hypercholesterolemia2003

    • Author(s)
      Mariko Harada-Shiba, Atsuko Takagi, et al.
    • Journal Title

      J Clin Endocrinol Metab 88, 6

      Pages: 2541-2547

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590964
  • [Journal Article] Long-term effect of low-density lipoprotein apheresis inpatients with homozygous familial hypercholesterolemia2003

    • Author(s)
      Hisashi Makino, Mariko Harada-Shiba
    • Journal Title

      Therap Apher Dial 7, 4

      Pages: 397-401

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590964
  • [Patent] オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する脂質異常症治療剤2012

    • Inventor(s)
      小比賀聡、斯波真理子他
    • Industrial Property Rights Holder
      国立大学法人大阪大学、独立行政法人国立循環器病研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-150292
    • Filing Date
      2012-07-04
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Patent] PCSK9の吸着体およびPCSK9の吸着器2011

    • Inventor(s)
      斯波真理子、湯浅由美子, 他
    • Industrial Property Rights Holder
      国立循環器病研究センター、株式会社カネカ
    • Filing Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Patent] 高コレステロール血症と動脈硬化の検出方法2011

    • Inventor(s)
      斯波真理子, 他
    • Industrial Property Rights Holder
      株式会社ビー・エム・エル、国立循環器病研究センター
    • Industrial Property Number
      2011-100682
    • Filing Date
      2011-04-28
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Patent] オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する高脂血症治療剤2011

    • Inventor(s)
      小比賀聡、斯波真理子, 他
    • Industrial Property Rights Holder
      国立大学法人大阪大学、独立行政法人国立循環器病研究センター
    • Industrial Property Number
      2011-271751
    • Filing Date
      2011-12-12
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Patent] 高コレステロール血症と動脈硬化の検出方法2011

    • Inventor(s)
      斯波真理子他
    • Industrial Property Rights Holder
      株式会社ビー・エム・エル、国立循環器病研究センター
    • Industrial Property Number
      2011-100682
    • Filing Date
      2011-04-28
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Patent] 高コレステロール血症の疾患モデルマウス2011

    • Inventor(s)
      斯波真理子、寒川賢治
    • Industrial Property Rights Holder
      財団法人ヒューマンサイエンス振興財団
    • Acquisition Date
      2011-05-13
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Patent] オリゴヌクレオチド、およびオリゴヌクレオチドを有効成分として含有する脂質異常症治療剤2010

    • Inventor(s)
      斯波真理子
    • Industrial Property Rights Holder
      斯波真理子
    • Industrial Property Number
      2010-195187
    • Filing Date
      2010-08-31
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] プロドラッグ型ホスホトリエステル修飾ギャップマー型核酸の合成とその2022

    • Author(s)
      杉本 紀人、林 淳祐、船木 涼平、保積 慧美、和田 郁人、斯波 真理子、和田 俊一、浦田 秀仁
    • Organizer
      日本薬学会第143年会(名古屋)
    • Data Source
      KAKENHI-PROJECT-19K05702
  • [Presentation] 肝臓指向型アンチセンス核酸の動態改善に向けた 新規GalNAcリガンドの構築と活性評価2021

    • Author(s)
      寺田知邑・和田郁人・山吉麻子・斯波真理子・小比賀聡・山本剛史
    • Organizer
      日本薬学会第141年会
    • Data Source
      KAKENHI-PROJECT-19H03656
  • [Presentation] プロドラッグ型ホスホトリエステル修飾を導入したGapmer核酸の合成とその評価2021

    • Author(s)
      杉本紀人、林淳祐、船木涼平、保積恵美、和田郁人、斯波真理子、和田俊一、浦田秀仁
    • Organizer
      日本核酸医薬学会 第6回年会
    • Data Source
      KAKENHI-PROJECT-19K05702
  • [Presentation] 肝臓標的型アンチセンス核酸のためのリガンド/リンカー構造の最適化研究2020

    • Author(s)
      寺田知邑・和田郁人・ 山吉麻子・ 和田健彦・ 斯波真理子・山本剛史
    • Organizer
      第14回バイオ関連化学シンポジウム
    • Data Source
      KAKENHI-PROJECT-19H03656
  • [Presentation] 3-Amino-1,2-Propanediol-Linked Monomeric GalNAc Phosphoramidite For Efficient Delivery Of Antisense Oligonucleotides To Hepatocytes2020

    • Author(s)
      Terada Chisato; Wada Fumito; Yamayoshi Asako; Harada-shiba Mariko; Obika Satoshi; Yamamoto Tsuyoshi
    • Organizer
      16th Annual Meeting of the Oligonucleotide Therapeutics Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03656
  • [Presentation] 脂質異常症を対象としたアンチセンスの開発2019

    • Author(s)
      斯波真理子, 和田郁人, 山本剛史
    • Organizer
      第35回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03393
  • [Presentation] ヒト肝臓キメラマウスを核酸医薬の評価モデルに応用するための基礎検討と実用性評価.2019

    • Author(s)
      和田郁人, 加国雅和, 斯波真理子
    • Organizer
      日本核酸医薬学会第5回年会
    • Data Source
      KAKENHI-PROJECT-19H03393
  • [Presentation] Evaluation of Antisense Oligonucleotides Targeting Human mRNA Using Chimeric Mice with Humanized Liver.2019

    • Author(s)
      Wada F, Kakuni M, Harada-Shiba M
    • Organizer
      15th OTS
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03393
  • [Presentation] Cholesterol efflux capacity and incident atherosclerotic cardiovascular disease events in a Japanese general population: The Suita Study2018

    • Author(s)
      Masatsune Ogura, Makoto Watanabe, Megumu Horiuchi, Yoshihiro Miyamoto, Mariko Harada-Shiba
    • Organizer
      第50回日本動脈硬化学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] Cholesterol efflux capacity and incident atherosclerotic cardiovascular disease events in a Japanese general population: The Suita Study2018

    • Author(s)
      Masatsune Ogura, Makoto Watanabe, Megumu Horiuchi, Yoshihiro Miyamoto, Mariko Harada-Shiba
    • Organizer
      第82回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] 家族性高コレステロール血症患者におけるHDL分画中のαトコフェロール濃度とコレステロール引き抜き能、動脈硬化との関連2018

    • Author(s)
      小倉正恒, 廣渡祐史, 真仁田大輔, 斯波真理子
    • Organizer
      第55回日本臨床分子医学会
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] Antioxidant property of HDL and cholesterol efflux capacity as mutually independent risk markers for atherosclerotic cardiovascular disease in patients with familial hypercholesterolemia2017

    • Author(s)
      Masatsune Ogura, Megumu Morimoto, Mariko Harada-Shiba
    • Organizer
      3rd World Congress of Clinical Lipidology Congress
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      2017-02-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] Cholesterol Efflux Capacity and Incident Atherosclerotic Cardiovascular Disease Events in a Japanese General Population2017

    • Author(s)
      Masatsune Ogura, Makoto Watanabe, Megumu Horiuchi, Yoshihiro Miyamoto, Mariko Harada-Shiba
    • Organizer
      European Society of Cardiology Congress 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] Fatty acid-binding protein 5 as a residual risk for atherosclerotic cardiovascular disease in patients with familial hypercholesterolemia2017

    • Author(s)
      Masatsune OGURA, Masato FURUHASHI, Megumu MORIMOTO, Tetsuji MIURA, Mariko HARADA-SHIBA
    • Organizer
      85th European Atherosclerosis Society Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] Antioxidant property of HDL as a novel residual risk for atherosclerotic cardiovascular disease in patients with familial hypercholesterolemia2017

    • Author(s)
      Masatsune Ogura, Megumu Morimoto, Mariko Harada-Shiba
    • Organizer
      第81回日本循環器学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] High-Density Lipoprotein Phospholipid Content and Apolipoprotein A-I Level Are Determinants of Cholesterol Efflux Capacity in Patients with Familial Hypercholesterolemia2016

    • Author(s)
      Masatsune Ogura, Megumu Morimoto, Mariko Harada-Shiba
    • Organizer
      84th European Atherosclerosis Society Congress
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2016-05-29
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] High-density Lipoprotein Phospholipid Content and Apolipoprotein A-I Level Are Determinants of Cholesterol Efflux Capacity in Patients with Familial Hypercholesterolemia2016

    • Author(s)
      Masatsune Ogura, Mariko Harada-Shiba.
    • Organizer
      84th European Atherosclerosis Society Congress
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2016-05-29
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] Antioxidant property of high-density lipoprotein predicts the presence of atherosclerotic cardiovascular disease and corneal arcus in patients with familial hypercholesterolemia2016

    • Author(s)
      Masatsune Ogura, Megumu Morimoto, Mariko Harada-Shiba
    • Organizer
      European Society of Cardiology Congress 2016
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2016-08-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] Cholesterol Efflux Capacity as a Promising Marker for Atherosclerotic and Metabolic diseases2016

    • Author(s)
      Masatsune Ogura, Mariko Harada-Shiba.
    • Organizer
      第80回日本循環器学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-03-18
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] Cholesterol Efflux Capacity in Patients with Familial Hypercholesterolemia2015

    • Author(s)
      Masatsune Ogura, Mika Hori, Mariko Harada-Shiba.
    • Organizer
      The 17th International Symposium on Atherosclerosis
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      2015-05-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] Cholesterol Efflux Capacity as an Emergent Biomarker in Patients with Familial Hypercholesterolemia already Prescribed Statin2015

    • Author(s)
      Masatsune Ogura, Mariko Harada-Shiba.
    • Organizer
      第79回日本循環器学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24
    • Data Source
      KAKENHI-PROJECT-15K09130
  • [Presentation] Development of Anti Atherogenic Drug Targeting Apolipoprotein C-III Using Bridgend Nucleic Acids(BNAs)2013

    • Author(s)
      Harada-Shiba M
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] The role of apheresis treatment in familial hypercholesterolemia (FH) - long-term experiences from the Osaka Cardiovascular Research Institute2012

    • Author(s)
      Harada-Shiba M
    • Organizer
      The European Society for Artificial Organs (ESAO XXXIX)
    • Place of Presentation
      Rostock, Germany
    • Invited
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] Bioactive Peptide Neuromedin U is Associated with Lipid Metabolism and Inflammation2012

    • Author(s)
      Hori M, Harada-Shiba M,
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] Guideline for Management of FH in Japan2012

    • Author(s)
      Harada-Shiba M
    • Organizer
      Familial Hypercholesterolaemia and Genetic Dyslipidaemia Satellite Meeting, ISA2012
    • Place of Presentation
      Australia
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] 家族性高コレステロール血症の診断と治療2012

    • Author(s)
      斯波真理子
    • Organizer
      第44回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] Genetic Analysis of Familial Hypercholesterolemia2012

    • Author(s)
      Harada-Shiba M
    • Organizer
      XVI International Symposium on Atherosclerosis (ISA2012)
    • Place of Presentation
      Sydney, Australia
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] FHにおける遺伝子異変と臨床的意義2012

    • Author(s)
      斯波真理子
    • Organizer
      第44回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] Has Statin Delayed the Onset Age of Coronary Artery Disease in Heterozygous Familial Hypercholesterolemia?2012

    • Author(s)
      Harada-Shiba M
    • Organizer
      XVI International Symposium on Atherosclerosis (ISA2012)
    • Place of Presentation
      Sydney, Australia
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] 原発性高コレステロール血症2011

    • Author(s)
      斯波真理子
    • Organizer
      第14回日本病態栄養学会年次学術集会 シンポジウム
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] Effects of LDL-apheresis on patients with familial hyperchol esterolemia-long term experience from Japan2011

    • Author(s)
      Harada-Shiba M
    • Organizer
      8 International Society for Apheresis Congress (ISFA Vienna 2011)
    • Place of Presentation
      Vienna, Austria(招待講演)
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] Change of serum levels in patients of substances removed by LDL-Apheresis(LDL-A)treatment2011

    • Author(s)
      Yuasa Y, Iwamoto N, Makino H, Osaki T, Minamide N, Usami M, Harada-Shiba M
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] Development of Nucleic Acid Durg for Dyslipidemia Using 2',4'-Control HDL in Vivo2011

    • Author(s)
      Harada-Shiba M
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      神奈川
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] Management of familial hypercholesterolemia (FH)2011

    • Author(s)
      Harada-Shiba M
    • Organizer
      第43回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      北海道
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] LDLアファレシスに除去される物質と病態2010

    • Author(s)
      斯波真理子
    • Organizer
      第31回日本アフェレシス学会学術大会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] 家族性高コレステロール血症の病態と核酸医療治療へのアプローチ2010

    • Author(s)
      斯波真理子
    • Organizer
      第20回アンチセンスシンポジウム
    • Place of Presentation
      神戸(招待講演)
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] Diagnosis and treatment of familial hypercholesterolemia (FH)2010

    • Author(s)
      Harada-Shiba M
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] 「LDL-Aによって除去される動脈硬化危険因子について」排液Proteome解析からの検討2010

    • Author(s)
      湯浅由美子, 槇野久士, 岩本紀之, 尾崎司, 南野直人, 宇佐美眞, 斯波真理子
    • Organizer
      第31回日本アフェレシス学会学術大会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] 家族性高コレステロール血症(FH)の診断・治療の今日的課題2010

    • Author(s)
      斯波真理子
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] Long term effect of LDL-apheresis on familial hypercholesterolemia(家族性高コレステロール血症に対する長期的効果)2010

    • Author(s)
      Harada-Shiba M
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-22591004
  • [Presentation] Management of familial hypercholesterolemia(FH)2010

    • Author(s)
      Harada-Shiba M
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      岐阜
    • Data Source
      KAKENHI-PROJECT-22591004
  • 1.  KATAOKA Kasunori (00130245)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  YAMAMURA Taku (20132938)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  SHIMOKADO Kentaro (30192115)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  Yamamoto Tsuyoshi (80636994)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 5.  和田 郁人 (90760843)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 6.  IWAMOTO Noriyuki (70534709)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KAWAGUCHI Akito (70214608)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MIYAKE Yasuko (00132936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  YAMASAKI Yuichi (00322678)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  Ogura Masatsune (30532486)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 19 results
  • 11.  MIYAMOTO Hiroshi (10312224)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 12.  WATANABE Makoto (40343446)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 13.  ASAUMI Yasuhide (20629315)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Urata Hidehito (80211085)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 15.  盛 英三 (90146598)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  山岡 哲二 (50243126)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  馬原 淳 (80416221)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 18.  高市 成子 (00093930)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  山本 章 (00028408)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  原田 敦史 (50302774)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  橘 敬祐 (30432446)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 22.  神吉 佐智子 (40411350)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  SIGANO Ryo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  MORIMOTO Megumu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 25.  荻野 均
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  西上 和宏
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  YAMANASHI Yoshihide
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  山吉 麻子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 29.  古橋 眞人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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