Okumura Yuushi 奥村裕司

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OKUMURA Yuushi 奥村裕司

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Researcher Number	70294725
Other IDs
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Affiliation (Current)	2025: 相模女子大学, 栄養科学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2022: 相模女子大学, 栄養科学部, 教授 2013 – 2015: 相模女子大学, 公私立大学の部局等, 教授 2012: 徳島大学, ヘルスバイオサイエンス研究部, 准教授 2009 – 2011: The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 2000 – 2006: 徳島大学, 分子酵素学研究センター, 助手
Review Section/Research Field	Principal Investigator Infectious disease medicine / Basic Section 54030:Infectious disease medicine-related / Sports science / Pathological medical chemistry / General medical chemistry Except Principal Investigator Metabolomics / Pathological medical chemistry / General medical chemistry / Environmental physiology (including Physical medicine and Nutritional physiology) / Science and Engineering / Biological Sciences
Keywords	Principal Investigator 膜結合型プロテアーゼ / ウイルス活性化酵素 / 高病原性感染症 / プロテアーゼ阻害剤 / 高病原性鳥インフルエンザウイルス / 膜結合型酵素 / 治療薬 / 酵素特異的阻害剤 / 酵素阻害剤 / 高病原性ウイルス感染症 … More / 筋委縮 / 筋萎縮 / 筋量決定サイトカイン / インフルエンザ / ウイルス / 上皮型ナトリウムチャンネル / 膜型セリンプロテアーゼ … More Except Principal Investigator ATP-ADP exchange reaction / ADP / ATP / 19S Cap / ミニプラスミン / プラスミン / 内科 / 骨粗鬆症 / 骨・カルシウム代謝異常 / 骨粗しょう症 / miRNA / SNPs / 骨・カルシウム代謝 / edema / blood-brain barrier / mini-plasmin encephalopathy / pneumonia / influenza associated / triggering protease for infection / Protease / Influenza virus / ウイルス増殖 / 血管-脳血管関門 / プロテアーゼ活性化レセプター / トリプシン / センダイウイルス / 脂肪酸代謝障害 / 血管-脳関門 / 浮腫 / 血液脳関門 / 肺炎 / インフルエンザ脳炎・脳症 / 感染トリガープロテアーゼ / プロテアーゼ / インフルエンザウイルス / Aggregation of heat-denatured proteins / Refolding / Proteasome / Molecular chaperone / 活性中心 / アンフォールディング / Hsp70 / 熱変性凝集塊形成 / リフォールディング / プロテアソーム / 分子シャペロン / 肥満 / PDK4 / UCP / 骨格筋 / 中鎖脂肪酸 / 栄養生理学 / 好中球 / エンドセリンレセプター / IL-5 / エオタキシン / 好酸球 / ケモカイン / エンドセリン(1-31) / エンドセリン(1-21) / アンチプラスミン / 癌浸潤 / プロセシング / マトリックスメタロプロテアーゼ / 癌転移 Less

The development of the new therapeutic drug by targeting host proteases: A novel regulatory method for highly pathogenic infectious diseases.Principal Investigator
- Principal Investigator
  
  Okumura Yuushi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Sagami Women's University
Regulation of bone metabolism by miRNAs located near the osteoporosis-related SNPs
- Principal Investigator
  
  Shimada Masako
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Sagami Women's University
The development of the new therapeutic drug which based on the structure of the virus activation enzyme: The new control method of the highly pathogenic infectious diseases.Principal Investigator
- Principal Investigator
  
  Okumura Yuushi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Sagami Women's University
Identification of novel proteases involved in the regulation of highly pathogenic avian influenza (HPAI) viruses infectionPrincipal Investigator
- Principal Investigator
  
  YUUSHI Okumura
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Sagami Women's University
  The University of Tokushima
Molecular mechanisms of muscle mass regulation : Identification of a novel protease involved in myostatin activation.Principal Investigator
- Principal Investigator
  
  OKUMURA Yuushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  The University of Tokushima
Medium chain fatty acid regulates uncoupling protein 3 expression in skeletal muscle
- Principal Investigator
  
  NIKAWA Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  The University of Tokushima
新規膜結合型線毛特異的セリンプロテアーゼのインフルエンザウイルス活性化と生理機能Principal Investigator
- Principal Investigator
  
  奥村裕司
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
上皮型ナトリウムチャンネルを活性化する新規膜型セリンプロテアーゼの発見と機序解明Principal Investigator
- Principal Investigator
  
  奥村裕司
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
生体内新規鍵物質エンドセリン(1-31)の生理機能:ケモカイン作用と未梢循環制御
- Principal Investigator
  
  木戸博
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokushima
Molecular chaperone activity of the 20S proteasome : Inhibitory activity of the substrate protein aggregation and unflodase activity
- Principal Investigator
  
  KIDO Hiroshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
Development of new influenza virus treatments based an the findings of triggering proteases for influenza virus entry into the cells and on the findings of protease-activating receptors
- Principal Investigator
  
  KIDO Hiroshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
癌細胞膜上のMMP9前躯体新規活性化機構の発見と癌細胞浸潤機序の解析
- Principal Investigator
  
  KIDO Hiroshi
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima

[Book] Surgery Frontier-蛋白質の構造、性質、分類-2011
- Author(s)
  奥村裕司, 他
- Total Pages
  3
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21500632
[Book] Surgery Frontier-蛋白質の構造、性質、分類-2011
- Author(s)
  奥村裕司、二川健
- Total Pages
  3
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21500632
[Book] Mechanobiology in Space : In Mechanosensing Biology (Ed M.Noda)2011
- Author(s)
  Yuushi Okumura, Takeshi Nikawa
- Total Pages
  8
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-21590257
[Book] Surgery Frontier-蛋白質の合成と分解-2011
- Author(s)
  奥村裕司、二川健
- Total Pages
  3
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21500632
[Book] Mechanobiology in Space : Mechanosensing Biology(Ed M. Noda)2011
- Author(s)
  Yuushi Okumura, and Takeshi Nikawa
- Total Pages
  8
- Publisher
  Springer社
- Data Source
  KAKENHI-PROJECT-21500632
[Book] Mechanobiology in Space : In Mechanosensing Biology(Ed M.Noda)2011
- Author(s)
  Yuushi Okumura, Takeshi NikaWa
- Total Pages
  8
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-21500632
[Book] Surgery Frontier-蛋白質の合成と分解-2011
- Author(s)
  奥村裕司, 他
- Total Pages
  3
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21500632
[Journal Article] Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza2021
- Author(s)
  Ohno Ayako、Maita Nobuo、Tabata Takanori、Nagano Hikaru、Arita Kyohei、Ariyoshi Mariko、Uchida Takayuki、Nakao Reiko、Ulla Anayt、Sugiura Kosuke、Kishimoto Koji、Teshima-Kondo Shigetada、Okumura Yuushi、Nikawa Takeshi
- Journal Title
  
  Life Science Alliance
  
  Volume: 4 Issue: 6 Pages: e202000849-e202000849
- DOI
  10.26508/lsa.202000849
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-19H05739, KAKENHI-PROJECT-19H04054, KAKENHI-PROJECT-18K08453, KAKENHI-PROJECT-18K10994, KAKENHI-PLANNED-19H05741, KAKENHI-PROJECT-19K05696
[Journal Article] Reactive oxygen species up-regulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells.2018
- Author(s)
  Yuushi Okumura et al.
- Journal Title
  
  Am J Physiol Cell Physiol.
  
  Volume: 印刷中 Issue: 6 Pages: C721-C731
- DOI
  10.1152/ajpcell.00184.2017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09585, KAKENHI-PLANNED-15H05937, KAKENHI-PROJECT-15H04931, KAKENHI-PROJECT-15J40096, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-18K08453, KAKENHI-PLANNED-15H05936, KAKENHI-PUBLICLY-18H04981, KAKENHI-ORGANIZER-15H05935
[Journal Article] Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin2016
- Author(s)
  Ohno A, Ochi A, Maita N, Ueji T, Bando A, Nakao R, Hirasaka K, Abe T, Teshima-Kondo S, Nemoto H, Okumura Y, Higashibata A, Yano S, Tochio H, Nikawa T
- Journal Title
  
  Arch Biochem Biophys
  
  Volume: 594 Pages: 1-7
- DOI
  10.1016/j.abb.2016.02.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350148, KAKENHI-PROJECT-25650024, KAKENHI-PROJECT-15K16499, KAKENHI-PROJECT-15J40096, KAKENHI-PROJECT-15K13747, KAKENHI-PROJECT-15H04931, KAKENHI-PROJECT-15H04960, KAKENHI-PROJECT-26350502, KAKENHI-PROJECT-15K09585
[Journal Article] UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion2016
- Author(s)
  Hirasaka K, Mills EM, Haruna M, Bando A, Ikeda C, Abe T, Kohno S, Nowinski SM, Lago CU, Akagi K, Tochio H, Ohno A, Teshima-Kondo S, Okumura Y, Nikawa T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 472 Issue: 1 Pages: 108-113
- DOI
  10.1016/j.bbrc.2016.02.075
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350148, KAKENHI-PROJECT-25650024, KAKENHI-PROJECT-15J40096, KAKENHI-PUBLICLY-16H01645, KAKENHI-PROJECT-15H04931, KAKENHI-PROJECT-15H04960, KAKENHI-PROJECT-15K09585
[Journal Article] Capric Acid Up-Regulates UCP3 Expression without PDK4 Induction in Mouse C2C12 Myotubes2016
- Author(s)
  Abe T, Hirasaka K, Kohno S, Tomida C, Haruna M, Uchida T, Ohno A, Oarada M, Teshima-Kondo S, Okumura Y, Choi I, Aoyama T, Terao J, Nikawa T*.
- Journal Title
  
  Journal of Nutritional Science and Vitaminology
  
  Volume: 62 Issue: 1 Pages: 32-39
- DOI
  10.3177/jnsv.62.32
- NAID
  130005148603
- ISSN
  0301-4800, 1881-7742
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01645, KAKENHI-PROJECT-15H04931, KAKENHI-PROJECT-15H04960, KAKENHI-PROJECT-26350148, KAKENHI-PROJECT-15K09585
[Journal Article] Modulation of cutaneous extracellular collagen contraction by phosphorylation status of p130Cas.2016
- Author(s)
  Yuushi Okumura et al.
- Journal Title
  
  J Physiol Sci.
  
  Volume: - Issue: 5 Pages: 613-622
- DOI
  10.1007/s12576-016-0493-9
- NAID
  40021302104
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09585
[Journal Article] A novel myogenic function residing in the 5’ non-coding region of Insulin receptor substrate-1 (Irs-1) transcript.2015
- Author(s)
  Nagano H, Yamagishi N, Tomida C, Yano C, Aibara K, Kohno S, Abe T, Ohno A, Hirasaka K, Okumura Y, Mills EM, Nikawa T, Teshima-Kondo S.
- Journal Title
  
  BMC Cell Biol
  
  Volume: in press Issue: 1 Pages: 1-10
- DOI
  10.1186/s12860-015-0054-8
- NAID
  120006859993
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390355, KAKENHI-PROJECT-24591481, KAKENHI-PROJECT-26350148, KAKENHI-PROJECT-15H04931
[Journal Article] Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70.2014
- Author(s)
  H Endo, M Yano, Y Okumura, H Kido
- Journal Title
  
  Cell Death and Disease
  
  Volume: 2014 Jan 30;5:e1027 Issue: 1 Pages: 1-10
- DOI
  10.1038/cddis.2013.550
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591477, KAKENHI-PROJECT-24249059, KAKENHI-PROJECT-24591481, KAKENHI-PROJECT-25670466, KAKENHI-PROJECT-25860787, KAKENHI-PROJECT-26350126
[Journal Article] Soy Glycinin Contains a Functional Inhibitory Sequence against Muscle Atrophy -Associated Ubiquitin Ligase Cbl-b2013
- Author(s)
  Abe T, Kohno S, Yama T, Ochi A, Suto T, Hirasaka K, Ohno A, Teshima-Kondo S, Okumura Y, Oarada M, Choi I, Mukai R, Terao J, Nikawa T
- Journal Title
  
  Int J Endocrinol
  
  Volume: 2013 Pages: 907565-907565
- DOI
  10.1155/2013/907565
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390198, KAKENHI-PROJECT-23650599, KAKENHI-PROJECT-24390355, KAKENHI-PROJECT-24591481, KAKENHI-PROJECT-24700753
[Journal Article] Cbl-b Is a Critical Regulator of Macrophage Activation Associated With Obesity-Induced Insulin Resistance in Mice2013
- Author(s)
  Abe T, Nikawa T, et al
- Journal Title
  
  Diabetes
  
  Volume: 62(6) Issue: 6 Pages: 1957-1969
- DOI
  10.2337/db12-0677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591658, KAKENHI-PROJECT-23390198, KAKENHI-PROJECT-23650599, KAKENHI-PROJECT-24390355, KAKENHI-PROJECT-24590585, KAKENHI-PROJECT-24591481, KAKENHI-PROJECT-24700753
[Journal Article] Isoflavones Derived from Soy Beans Prevent MuRF1-Mediated Muscle Atrophy in C2C12 Myotubes through SIRT1 Activation2013
- Author(s)
  Yuushi Okumura et al.
- Journal Title
  
  Journal of Nutritional Science and Vitaminology
  
  Volume: 59 Issue: 4 Pages: 317-324
- DOI
  10.3177/jnsv.59.317
- NAID
  130004491354
- ISSN
  0301-4800, 1881-7742
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591481
[Journal Article] Unloading stress disturbs muscle regeneration through perturbed recruitment and function of macrophages.2012
- Author(s)
  Kohno S, Nikawa T, et al
- Journal Title
  
  J Appl Physiol
  
  Volume: 112(10) Issue: 10 Pages: 1773-1782
- DOI
  10.1152/japplphysiol.00103.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591658, KAKENHI-PROJECT-23390198, KAKENHI-PROJECT-23650599, KAKENHI-PROJECT-24390355, KAKENHI-PROJECT-24591481, KAKENHI-PROJECT-24700753
[Journal Article] An Intracellular Fragment of Osteoactivin Formed by Ectodomain Shedding Translocated to the Nucleoplasm and Bound to RNA Binding Proteins2012
- Author(s)
  Utsunomiya K, Nikawa T, et al
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 76 Issue: 12 Pages: 2225-2229
- DOI
  10.1271/bbb.120515
- NAID
  10031146836
- ISSN
  0916-8451, 1347-6947
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591658, KAKENHI-PROJECT-24591481
[Journal Article] RANTES Secreted from Macrophages Disturbed Skeletal Muscle Regeneration after Cardiotoxin Injection in Cbl-b-Deficient Mice2011
- Author(s)
  Kohno S, Okumura Y, Nikawa T(他10名, 12番目)
- Journal Title
  
  Muscle & Nerve
  
  Volume: 43(2) Issue: 2 Pages: 223-229
- DOI
  10.1002/mus.21829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500632, KAKENHI-PROJECT-21590257, KAKENHI-PROJECT-22591658
[Journal Article] "Hybrid exercise" prevents muscle atrophy in association with a distinct gene expression pattern2011
- Author(s)
  Matsugaki T, Shiba N, Kohno S, Nikawa T, Hirasaka K, Okumura Y, Ishidoh K, Soejima T, Yoshimitsu K, Nagata K
- Journal Title
  
  Kurume Med J
  
  Volume: 57(4) Pages: 101-108
- NAID
  130001055545
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21778671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590257
[Journal Article] Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure2011
- Author(s)
  Kido H, Okumura Y, Takahashi E., et al
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1824(1) Issue: 1 Pages: 186-194
- DOI
  10.1016/j.bbapap.2011.07.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249061, KAKENHI-PROJECT-21500632, KAKENHI-PROJECT-23591477, KAKENHI-PROJECT-23791180
[Journal Article] "Hybrid Exercise" prevents muscle atrophy in association with a distinct gene expression pattern2010
- Author(s)
  Matsugaki T, Nikawa T, Okumura Y(他7名, 6番目)
- Journal Title
  
  Kurume Medical Journal
  
  Volume: 57(4) Pages: 1-8
- NAID
  130001055545
- URL
  http://dx.doi.org/10.2739/kurumemedj.57.101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500632
[Journal Article] Novel type II transmembrane serine proteases, MSPL and TMPRSS13, proteolytically activate membrane fusion activity of hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.2010
- Author(s)
  Y.Okumura, et al.
- Journal Title
  
  Journal of Vrology
  
  Volume: 84(10) Pages: 5089-5096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590257
[Journal Article] Novel type II transmembrane serine proteases, MSPL and TMPRSS13, proteolytically activate membrane fusion activity of hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.2010
- Author(s)
  Yuushi Okumura, et al.
- Journal Title
  
  Journal of Virology 84(10)(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500632
[Journal Article] Novel type II transmembrane serine proteases, MSPL and TMPRSS13, proteolytically activate membrane fusion activity of hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.2010
- Author(s)
  Yuushi Okumura, et al.
- Journal Title
  
  Journal of Virology
  
  Volume: 84(10) Pages: 5089-5096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500632
[Journal Article] Novel type II transmembrane serine proteases, MSPL and TMPRSS13, proteolytically activate membrane fusion activity of hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication2010
- Author(s)
  Okumura Y, Takahashi E, Kido H(他7名, 1番目)
- Journal Title
  
  Journal of Virology
  
  Volume: 84(10) Issue: 10 Pages: 5089-5096
- DOI
  10.1128/jvi.02605-09
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500632
[Journal Article] Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro.2009
- Author(s)
  Yuushi Okumura, et al.
- Journal Title
  
  PLoS One 4(11)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500632
[Journal Article] Polyphenols prevent clinorotation-induced expression of atrogenes in mouse C2C12 skeletal myotubes2009
- Author(s)
  Hemdan DI, Hirasaka K, Nakao R, Kohno S, Kagawa S, Abe T, Harada-Sukeno A, Okumura Y, Nakaya Y, Terao J, Nikawa T
- Journal Title
  
  J Med Invest
  
  Volume: 56(1-2) Pages: 26-32
- NAID
  130004465163
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/19262011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590257
[Journal Article] Awa(Tokushima) lactate-fermented tea as well as green tea enhance the effect of diet restriction on obesity in rats2009
- Author(s)
  Sogawa M, Seura T, Kohno S, Hirasaka K, Yamaguchi Y, Takagaki R, Harada A, Okumura Y, Yamamoto S, Kishi K, Nikawa T
- Journal Title
  
  J Med Invest
  
  Volume: 56(1-2) Pages: 42-48
- NAID
  130004465165
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/19262013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590257
[Journal Article] Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading2009
- Author(s)
  N akao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T
- Journal Title
  
  Mol Cell Biol
  
  Volume: 17 Issue: 17 Pages: 4798-4811
- DOI
  10.1128/mcb.01347-08
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300149, KAKENHI-PROJECT-21500632
[Journal Article] Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro2009
- Author(s)
  Kam YW, Okumura Y, Kido H(他3名, 2番目)
- Journal Title
  
  PLoS One
  
  Volume: 4(11)
- URL
  http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500632
[Journal Article] Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading2009
- Author(s)
  Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T
- Journal Title
  
  Mol Cell Biol
  
  Volume: 29(17) Pages: 4798-4811
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/19546233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590257
[Journal Article] Glucose infusion suppresses surgery-induced muscle protein breakdown by inhibiting ubiquitin-proteasome pathway in rats2009
- Author(s)
  Mikura M, Yamaoka I, Doi M, Kawano Y, Nakayama M, Nakao R, Hirasaka K, Okumura Y, Nikawa T
- Journal Title
  
  Anesthesiology
  
  Volume: 110(1) Pages: 81-88
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/19104174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590257
[Journal Article] Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates urokinase-type plasminogen activator and the proteolytic activation is negatively regulated by glycosaminoglycans2006
- Author(s)
  Yuushi Okumura et al.
- Journal Title
  
  Biochemical Journal 400
  
  Pages: 551-561
- Data Source
  KAKENHI-PROJECT-17790213
[Journal Article] 広がりを見せるプロテアーゼファミリー、II型膜結合型セリンプロテアーゼの生理機能2006
- Author(s)
  奥村裕司
- Journal Title
  
  生化学 78・12
  
  Pages: 1155-1159
- NAID
  10018675676
- Data Source
  KAKENHI-PROJECT-17790213
[Journal Article] Cloning and Characterization of Transmembrane-Type Serine Protease from Rat Kidney, a New Sodium Channel Activator2003
- Author(s)
  Yuushi Okumura et al.
- Journal Title
  
  Biological Chemistry 384
  
  Pages: 1483-1495
- Data Source
  KAKENHI-PROJECT-15790154
[Patent] 高病原性インフルエンザウイルス感染に関わる宿主酵素MSPL特異的な阻害ペプチドの開発2018
- Inventor(s)
  奥村裕司他
- Industrial Property Rights Holder
  奥村裕司他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-126822
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K08453
[Presentation] 高病原性インフルエンザ感染に関わる宿主酵素MSPLと阻害剤との複合体構造2018
- Author(s)
  奥村　裕司他
- Organizer
  日本病態プロテアーゼ学会
- Data Source
  KAKENHI-PROJECT-18K08453
[Presentation] 高病原性インフルエンザ感染に関わる宿主酵素MSPLと阻害ペプチドとの複合体構造2017
- Author(s)
  奥村　裕司　他
- Organizer
  日本栄養・食糧学会
- Data Source
  KAKENHI-PROJECT-15K09585
[Presentation] 無重力ストレスによる筋委縮における酸化ストレスの重要性2017
- Author(s)
  奥村　裕司　他
- Organizer
  日本病態プロテアーゼ学会
- Data Source
  KAKENHI-PROJECT-15K09585
[Presentation] 廃用性筋委縮原因酵素Cbl-bと阻害ペプチドCblinとの複合体結晶構造解析2016
- Author(s)
  奥村　裕司　他
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター（大阪）
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-15K09585
[Presentation] 骨格筋細胞分化を制御する新たな機能性RNAの解明2016
- Author(s)
  奥村　裕司　他
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K09585
[Presentation] II型膜貫通型セリンプロテアーゼMSPLとペプチド性阻害剤との複合体結晶構造解析2016
- Author(s)
  奥村　裕司　他
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K09585
[Presentation] A novel myogenic functional residing in the 5'non-cording regain of Insulin receptor substrate-1(Irs-1) transcript2015
- Author(s)
  Yuushi Okumura et al.
- Organizer
  12th Asian Congress of Nutrition
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09585
[Presentation] UCP3と Hax-1の相互作用様式の解明2015
- Author(s)
  奥村裕司　他
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  ANAクラウンプラザホテルグランコート名古屋
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-15K09585
[Presentation] ユビキチンリガーゼCbl-bと脂肪組織浸潤マクロファージの活性化2013
- Author(s)
  奥村裕司　他
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府）
- Data Source
  KAKENHI-PROJECT-24591481
[Presentation] II型膜結合型セリンプロテアーゼ、MSPL/TMPRSS13-KOマウスにおける高病原性鳥インフルエンザウイルス(H5N1)の感染病態解析2012
- Author(s)
  奥村裕司　他
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  オークラアクトシティホテル浜松（静岡県）
- Data Source
  KAKENHI-PROJECT-24591481
[Presentation] II型膜結合型セリンプロテアーゼのMSPL/TMPRSS13のノックアウトマウスは高病原性鳥インフルエンザウイルスの増殖を抑制する2012
- Author(s)
  奥村裕司　他
- Organizer
  日本生化学会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-24591481
[Presentation] TYPE II TRANSMEMBRANE SERINE PROTEASES MSPL AND TMPRSS13 PROTEOLYTICALLY ACTIVATE MEMBRANE FUSION ACTIVITY OF HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS AND INDUCE THEIR MULTICYCLE REPLICATION2011
- Author(s)
  Yuushi Okumura et al
- Organizer
  7th General Meeting of the International Proteolysis Society
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] Molecular mechanism of unloading-induced muscle atrophy and development of its countermeasures2011
- Author(s)
  Takeshi Nikawa, Nakao Reiko, Katsuya Hirasaka, Akira Higashibata, Inho Choi, Makoto Asashima, Edward M. Mills, Yuushi Okumura
- Organizer
  2nd Annual Meeting of the Korean Microgravity Society, 2011
- Place of Presentation
  延世大学原州キャンパス(韓国・原州市)
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-21590257
[Presentation] 高病原性鳥インフルエンザウイルスヘマグルテニンの新規活性化酵素、II型膜結合型セリンプロテアーゼのMSPL/TMRSS13の性状解析2011
- Author(s)
  奥村裕司, 他
- Organizer
  日本生化学会
- Place of Presentation
  京都国際会議場(京都府)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] Unloadingストレス下における筋固有の生体反応機構:オステオアクチビンの発現調節と作用機序について2011
- Author(s)
  奥村裕司, 他
- Organizer
  日本栄養・食糧学会
- Place of Presentation
  御茶の水女子大(東京都)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] Unloadingストレス下における筋固有の生体反応機構:オステオアクテビンの発現調節と作用機序について2011
- Author(s)
  奥村裕司, 他
- Organizer
  日本栄養・食糧学会
- Place of Presentation
  御茶の水女子大(東京都)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 高病原性鳥インフルエンザウイルスヘマグルチニンの新規活性化酵素、II型膜結合型セリンプロテアーゼのMSPL/ TMPRSS13の性状解析2011
- Author(s)
  奥村裕司, 他
- Organizer
  日本生化学会
- Place of Presentation
  京都国際会議場(京都府)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] TYPE II TRANSMEMBRANE SERINE PROTEASES MSPL AND TMPRSS13 PROTEOLYTICALLY ACTIVATE MEMBRANE FUSION ACTIVITY OF HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS AND INDUCE2011
- Author(s)
  Yuushi Okumura, et al
- Organizer
  7th General Meeting of the International Proteolysis Society
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 骨格筋の脂肪酸代謝への中鎖脂肪酸の作用2010
- Author(s)
  安倍知紀、市川雅子、平坂勝也、河野尚平、山下結衣、真板綾子、原田晃子、奥村裕司、青山敏明、二川健
- Organizer
  第43回日本栄養・食糧学会中国・四国支部大会
- Place of Presentation
  高知女子大学(高知市)
- Year and Date
  2010-10-06
- Data Source
  KAKENHI-PROJECT-21590257
[Presentation] Novel type II transmembrane serine proteases, MSPL and TMPRSS13, proteolytically activate membrane fusion activity of hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication2010
- Author(s)
  Yuushi Okumura et al
- Organizer
  Cell Symposia, Influenza ; translating basic insights
- Place of Presentation
  Washington Marriott Hotel, Washington D. C., USA
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] II型膜結合型セリンプロテアーゼ、MSPL/ TMPRSS13による高病原性鳥インフルエンザウイルス感染活性化と、その阻害剤の検討2010
- Author(s)
  奥村裕司, 他
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター(大阪府)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] Novel type II transmembrane serine proteases, MSPL and TMPRSS13, proteolytically activate membrane fusion activity of hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication2010
- Author(s)
  Yuushi Okumura, et al.
- Organizer
  Cell Symposia, Influenza ; translating basicinsights
- Place of Presentation
  Washington Marriott Hotel, Washington D.C., USA
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 高病原性鳥インフルエンザウイルスはII型膜結合型セリンプロテアーゼのMSPL/TMPRSS13によってヘマグルチニンが切断され、膜融合が活性化される2010
- Author(s)
  奥村裕司, 他
- Organizer
  日本ウイルス学会
- Place of Presentation
  あわぎんホール(徳島県)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 骨格筋における無重力感知の分子機構:ユビキチンリガーゼCbl-bの発現調節について2010
- Author(s)
  奥村裕司, 他
- Organizer
  日本栄養・食糧学会
- Place of Presentation
  アスティとくしま(徳島県)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 高病原性鳥インフルエンザウイルスはII型膜結合型セリンプロテアーゼのMSPL/ TMPRSS13によってヘマグルチニンが切断され、膜融合が活性化される2010
- Author(s)
  奥村裕司, 他
- Organizer
  日本ウイルス学会2010
- Place of Presentation
  あわぎんホール(徳島県)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] II型膜結合型セリンプロテアーゼ、MSPL/TMPRSS13による高病原性鳥インフルエンザウイルス感染活性化と、その阻害剤の検討2010
- Author(s)
  奥村裕司, 他
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター(大阪府)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 骨格筋における無重力感知の分子機構:ユビキチンリガーゼCb1-bの発現調節について2010
- Author(s)
  奥村裕司, 他
- Organizer
  日本栄養・食糧学会
- Place of Presentation
  アスティとくしま(徳島県)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] Role of the host cellular processing proteases in influenza virus infection2009
- Author(s)
  Yuushi Okumura
- Organizer
  6^<th> General Meeting of the International Proteolysis Society
- Place of Presentation
  Surfers Paradise Marriott Resort (Australia)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 高病原性鳥インフルエンザウイルスはII型膜結合型セリンプロテアーゼ、MSPL/ TMPRSS13により活性化され、その膜融合活性はインヒビターによって低下する2009
- Author(s)
  奥村裕司, 他
- Organizer
  日本生化学会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 骨格筋における中鎖脂肪酸の新規機能の探索2009
- Author(s)
  安倍知紀、平坂勝也、加川祥子、中尾玲子、河野尚平、矢野桃子、奥村裕司、青山敏明、二川健
- Organizer
  第42回日本栄養・食糧学会中国・四国支部大会
- Place of Presentation
  鳥取大学(鳥取)
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-21590257
[Presentation] 寝たきりにおける筋固有の応答機構:オステオアクチビンの発現調節と活性化、作用機構について2009
- Author(s)
  奥村裕司, 他
- Organizer
  日本栄養・食糧学会
- Place of Presentation
  ブリックホール(長崎県)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 寝たきりにおける筋固有の応答機構:オステオアクチビンの発現調節と活性化、作用機構について2009
- Author(s)
  奥村裕司, 他
- Organizer
  日本栄養・食糧学会
- Place of Presentation
  日本ブリックホール(長崎県)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 高病原性鳥インフルエンザウイルス感染活性化酵素として新たに見出されたII型膜結合型セリンプロテアーゼ、MSPL/ TMPRSS13による膜融合活性の証明2009
- Author(s)
  奥村裕司, 他
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター(大阪府)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] Role of the host cellular processing proteases in influenza virus infection2009
- Author(s)
  Yuushi Okumura
- Organizer
  6th General Meeting of the International Proteolysis Society
- Place of Presentation
  Surfers Paradise Marriott Resort(Australia)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 高病原性鳥インフルエンザウイルスはII型膜結合型セリンプロテアーゼ、MSPL/TMPRSS13により活性化され、その膜融合活性はインヒビターによって低下する2009
- Author(s)
  奥村裕司, 他
- Organizer
  日本生化学会
- Place of Presentation
  神戸国際会議場(兵庫県〉
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] 高病原性鳥インフルエンザウイルス感染活性化酵素として新たに見出されたII型膜結合型セリンプロテアーゼ、MSPL/TMPRSS13による膜融合活性の証明2009
- Author(s)
  奥村裕司, 他
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター(大阪府)
- Data Source
  KAKENHI-PROJECT-21500632
[Presentation] Myostatin活性化を標的としたプロテアーゼ阻害剤はステロイド性筋萎縮を抑制する
- Author(s)
  奥村裕司　他
- Organizer
  日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2014-08-08 – 2014-08-09
- Data Source
  KAKENHI-PROJECT-24591481

1. KIDO Hiroshi (50144978)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. NIKAWA Takeshi (20263824)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
3. Shimada Masako (30637369)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. NAKAYA Yutaka (50136222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HIRASAKA Katsuya (70432747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. YANO Mihiro (40304555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. TASHIRO Masato (90111343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YAMADA Hiroshi (30343304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OUCHI Masato (80107185)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 永野ひかる (10748924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 手嶋茂忠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 武田伸一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 有田恭平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okumura Yuushi 奥村 裕司

OKUMURA Yuushi 奥村 裕司

Research Projects

Research Products

Co-Researchers

The development of the new therapeutic drug by targeting host proteases: A novel regulatory method for highly pathogenic infectious diseases.Principal Investigator

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Regulation of bone metabolism by miRNAs located near the osteoporosis-related SNPs

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The development of the new therapeutic drug which based on the structure of the virus activation enzyme: The new control method of the highly pathogenic infectious diseases.Principal Investigator

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Identification of novel proteases involved in the regulation of highly pathogenic avian influenza (HPAI) viruses infectionPrincipal Investigator

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Molecular mechanisms of muscle mass regulation : Identification of a novel protease involved in myostatin activation.Principal Investigator

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Medium chain fatty acid regulates uncoupling protein 3 expression in skeletal muscle

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新規膜結合型線毛特異的セリンプロテアーゼのインフルエンザウイルス活性化と生理機能Principal Investigator

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上皮型ナトリウムチャンネルを活性化する新規膜型セリンプロテアーゼの発見と機序解明Principal Investigator

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生体内新規鍵物質エンドセリン(1-31)の生理機能:ケモカイン作用と未梢循環制御

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Molecular chaperone activity of the 20S proteasome : Inhibitory activity of the substrate protein aggregation and unflodase activity

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Development of new influenza virus treatments based an the findings of triggering proteases for influenza virus entry into the cells and on the findings of protease-activating receptors

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癌細胞膜上のMMP9前躯体新規活性化機構の発見と癌細胞浸潤機序の解析

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[Book] Surgery Frontier-蛋白質の構造、性質、分類-2011

Author(s)

Total Pages

Okumura Yuushi 奥村裕司

OKUMURA Yuushi 奥村裕司