KOSHIBA Seizo 小柴生造

Researcher Number	70332301
Other IDs
Affiliation (Current)	2025: 東北大学, 未来型医療創成センター, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 東北大学, 未来型医療創成センター, 教授 2017 – 2020: 東北大学, 東北メディカル・メガバンク機構, 教授 2014 – 2016: 東北大学, 東北メディカル・メガバンク機構, 准教授 2013: 独立行政法人理化学研究所, 生命システム研究センター, 客員研究員 2012: 独立行政法人理化学研究所, NMRパイプライン高度化研究チーム, 上級研究員
Review Section/Research Field	Principal Investigator Structural biochemistry Except Principal Investigator Basic Section 55060:Emergency medicine-related / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Basic Section 55010:General surgery and pediatric surgery-related / Basic Section 53020:Cardiology-related / General physiology / Eating habits
Keywords	Principal Investigator 動的構造 / 19F-NMR / In-Cell NMR / NMR / 酵素 / PAH / Keap1 / クライオ電子顕微鏡 / 動的構造変化 / 相互作用 … More / 細胞内環境 / タンパク質 / フッ素 / VRK1 / In-cell / キナーゼ … More Except Principal Investigator メタボローム / 治療反応生 / 治療反応性 / メタボローム関連解析 / ゲノム関連解析 / サブクラス分類 / 敗血症 / 遺伝学的リスク / 生活習慣病 / 個別化予防 / 乳癌 / ディープフェノタイピング / 人工知能 / バイオマーカー / オミックス / 収縮能が保持された心不全 / 個別化医療 / 酸塩基平衡 / 体液 / 腎 / 重炭酸 / クエン酸 / 尿毒症物質 / 経口アルカリ性化剤 / アルカリ性化剤 / 酸性尿 / 慢性腎臓病 / オミックス解析 / 栄養素 / 食事 / 脳形態 / 認知指標 Less

Study regarding metabolomics of participants with higher genetic risk of life-style related diseases
- Principal Investigator
  
  寳澤篤
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Tohoku University
Identifying Novel Sepsis Endotypes
- Principal Investigator
  
  工藤大介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Tohoku University
Interdisciplinary fusion research for precision medicine in heart failure patients with preserved ejection fraction
- Principal Investigator
  
  Anzai Toshihisa
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hokkaido University
Integrated analysis of genetic polymorphisms, lifestyle and plasma metabolomics for breast cancer morbidity risk reduction
- Principal Investigator
  
  Ishida Takanori
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Tohoku University
Effects of Diet and Nutrients on Cognitive Indices and Brain Morphology: An Examination Using Omics Analysis
- Principal Investigator
  
  Kogure Mana
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Tohoku University
Structural analysis of in vivo protein-ligand interactions by 19F-NMR and PREPrincipal Investigator
- Principal Investigator
  
  Koshiba Seizo
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tohoku University
Reno-protective mechanism by therapeutic intervention of metabolic acidosis on chronic kidney disease
- Principal Investigator
  
  Abe Michiaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tohoku University
Protein 19F Labeling Strategy for In-Cell NMR and Functional AnalysesPrincipal Investigator
- Principal Investigator
  
  Koshiba Seizo
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tohoku University
Dynamic behavior of human VRK1 kinase in living cellsPrincipal Investigator
- Principal Investigator
  
  KOSHIBA Seizo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tohoku University
  Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2012 Other

All Journal Article Presentation Book Patent Other

[Book] 最新医学 74巻2号特集　バイオインフォマティクスの進展・臨床応用2019
- Author(s)
  小柴生造
- Total Pages
  312
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-17K07298
[Book] 遺伝子医学MOOK(32)　難病研究up-to-date2017
- Author(s)
  小柴生造、山本雅之
- Total Pages
  280
- Publisher
  メディカルドゥ
- ISBN
  9784944157624
- Data Source
  KAKENHI-PROJECT-26440018
[Book] 遺伝子医学MOOK(32)　難病研究up-to-date2017
- Author(s)
  小柴生造、山本雅之
- Total Pages
  280
- Publisher
  メディカルドゥ
- ISBN
  9784944157624
- Data Source
  KAKENHI-PROJECT-17K07298
[Journal Article] Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut22023
- Author(s)
  Fujino Mitsunori、Morito Naoki、Hayashi Takuto、Ojima Masami、Ishibashi Shun、Kuno Akihiro、Koshiba Seizo、Yamagata Kunihiro、Takahashi Satoru
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 6
- DOI
  10.1172/jci.insight.163306
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-21K08220
[Journal Article] Genome-wide association study of the risk of chronic kidney disease and kidney-related traits in the Japanese population: J-Kidney-Biobank2022
- Author(s)
  Sugawara Yuka、Hirakawa Yosuke、Nagasu Hajime、Narita Akira、Katayama Akihiro、Wada Jun、Shimizu Miho、Wada Takashi、Kitamura Hiromasa、Nakano Toshiaki、Yokoi Hideki、Yanagita Motoko、Goto Shin、Narita Ichiei、Koshiba Seizo、Tamiya Gen、Nangaku Masaomi、Yamamoto Masayuki、Kashihara Naoki
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 68 Issue: 2 Pages: 55-64
- DOI
  10.1038/s10038-022-01094-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10439, KAKENHI-PROJECT-19H03674, KAKENHI-PROJECT-21H02937, KAKENHI-PROJECT-17K07298, KAKENHI-PUBLICLY-21H00179
[Journal Article] Plasma metabolic disturbances during pregnancy and postpartum in women with depression2022
- Author(s)
  Z Yu, N Matsukawa, D Saigusa, I. N. Motoike, C Ono, Y Okamura, T Onuma, Y Takahashi, M Sakai, H Kudo, T Obara, K Murakami, M Shirota, S Kikuchi, N Kobayashi, Y Kikuchi, J Sugawara, N Minegishi, S Ogishima, K Kinoshita, M Yamamoto, N Yaegashi, S Kuriyama, S Koshiba, H Tomita
- Journal Title
  
  iScience
  
  Volume: 25(12) Issue: 12 Pages: 105666-105666
- DOI
  10.1016/j.isci.2022.105666
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15742, KAKENHI-PROJECT-20H03374, KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-20K07962, KAKENHI-PROJECT-21H03537
[Journal Article] Maternal Baseline Characteristics and Perinatal Outcomes: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study2022
- Author(s)
  Sugawara, J.,et al., Koshiba, S., et al., Yamamoto, M.（合計32名、本研究者は21番目）
- Journal Title
  
  Journal of Epidemiology
  
  Volume: 32 Issue: 2 Pages: 69-79
- DOI
  10.2188/jea.JE20200338
- NAID
  130008157950
- ISSN
  0917-5040, 1349-9092
- Year and Date
  2022-02-05
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-20K07352, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-17K01011, KAKENHI-PROJECT-18K11545, KAKENHI-PROJECT-21H03537
[Journal Article] Identification of biomarkers to diagnose diseases and find adverse drug reactions by metabolomics2021
- Author(s)
  Saigusa Daisuke、Matsukawa Naomi、Hishinuma Eiji、Koshiba Seizo
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 37 Pages: 100373-100373
- DOI
  10.1016/j.dmpk.2020.11.008
- NAID
  210000172800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03374, KAKENHI-PROJECT-17K07298
[Journal Article] Nrf2 plays a critical role in the metabolic response during and after spaceflight2021
- Author(s)
  Uruno A、Saigusa D、Suzuki T、Yumoto A、Nakamura T、Matsukawa N、Yamazaki T、Saito R、Taguchi K、Suzuki M、Suzuki N、Otsuki A、Katsuoka F、Hishinuma E、Okada R、Koshiba S、Tomioka Y、Shimizu R、Shirakawa M、Kensler TW.、Shiba D、Yamamoto M
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1381-1381
- DOI
  10.1038/s42003-021-02904-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-19H03555, KAKENHI-PROJECT-20H03374, KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-20K07352, KAKENHI-PROJECT-23K21372
[Journal Article] Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study2021
- Author(s)
  Hozawa A, Tanno K, Nakaya N, Nakamura T, Tsuchiya N, Hirata T, Narita A, Kogure M, Nochioka K, Sasaki R, Takanashi N, Otsuka K, Sakata K, Kuriyama S, Kikuya M, 13名略, Kobayashi T, 53名略, Yamamoto M.
- Journal Title
  
  Journal of Epidemiology
  
  Volume: 31 Issue: 1 Pages: 65-76
- DOI
  10.2188/jea.JE20190271
- NAID
  130007966030
- ISSN
  0917-5040, 1349-9092
- Year and Date
  2021-01-05
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01011, KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-18K08523, KAKENHI-PROJECT-18K11420, KAKENHI-PROJECT-18K11545, KAKENHI-PROJECT-19K08547, KAKENHI-PUBLICLY-18H04795, KAKENHI-PUBLICLY-19H05200, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-17H00840, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-19H03555, KAKENHI-PROJECT-18H02940
[Journal Article] Molecular basis for the disruption of Keap1?Nrf2 interaction via Hinge & Latch mechanism2021
- Author(s)
  Horie Yuta、Suzuki Takafumi、Inoue Jin、Iso Tatsuro、Wells Geoffrey、Moore Terry W.、Mizushima Tsunehiro、Dinkova-Kostova Albena T.、Kasai Takuma、Kamei Takashi、Koshiba Seizo、Yamamoto Masayuki
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 576-576
- DOI
  10.1038/s42003-021-02100-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07298
[Journal Article] Metabolic Profiling of the Cerebrospinal Fluid in Pediatric Epilepsy2020
- Author(s)
  Akiyama T, Saigusa D, Hyodo Y, Umeda K, Saijo R, Koshiba S, Kobayashi K
- Journal Title
  
  Acta Medica Okayama
  
  Volume: 74 Issue: 1 Pages: 65-72
- DOI
  10.18926/AMO/57955
- NAID
  120006795622
- URL
  https://ousar.lib.okayama-u.ac.jp/57955
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07298
[Journal Article] Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective.2020
- Author(s)
  Kuriyama S, Metoki H, Kikuya M, Obara T, Ishikuro M, Yamanaka C, Nagai M, Matsubara H, Kobayashi T, 57名略, Yamamoto M.
- Journal Title
  
  Int J Epidemiol.
  
  Volume: 49(1) Issue: 1 Pages: 18-19
- DOI
  10.1093/ije/dyz169
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01011, KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-18K11420, KAKENHI-PROJECT-18K11545, KAKENHI-PUBLICLY-18H04795, KAKENHI-PUBLICLY-19H05200, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-17K17584
[Journal Article] jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population2020
- Author(s)
  Tadaka Shu、Hishinuma Eiji、Komaki Shohei、Motoike Ikuko N、Kawashima Junko、Saigusa Daisuke、Inoue Jin、Takayama Jun、Okamura Yasunobu、Aoki Yuichi、Shirota Matsuyuki、Otsuki Akihito、Katsuoka Fumiki、Shimizu Atsushi、Tamiya Gen、Koshiba Seizo、Sasaki Makoto、Yamamoto Masayuki、Kinoshita Kengo
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 49 Issue: D1 Pages: D536-D544
- DOI
  10.1093/nar/gkaa1034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07298
[Journal Article] Nrf2 contributes to the weight gain of mice during space travel2020
- Author(s)
  Suzuki, T., et al., Koshiba, S. et al., Yamamoto, M.（合計37名、本研究者は18番目）
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 496-496
- DOI
  10.1038/s42003-020-01227-2
- NAID
  120007161347
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-20K07352, KAKENHI-PROJECT-20K09474, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H02614, KAKENHI-PROJECT-18H02621, KAKENHI-ORGANIZER-15H05935, KAKENHI-WRAPUP-20H05615
[Journal Article] O-Glycan-Altered Extracellular Vesicles: A Specific Serum Marker Elevated in Pancreatic Cancer2020
- Author(s)
  Yokose, T., et al., Koshiba, S., et al., Kitagawa, Y.（合計32名、本研究者は26番目）
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 9 Pages: 2469-2469
- DOI
  10.3390/cancers12092469
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-19K18132, KAKENHI-PROJECT-19H03856, KAKENHI-PROJECT-18K06921, KAKENHI-PROJECT-18K08552
[Journal Article] Amino-acid selective isotope labeling enables simultaneous overlapping signal decomposition and information extraction from NMR spectra2020
- Author(s)
  Takuma Kasai, Shunsuke Ono, Seizo Koshiba, Masayuki Yamamoto, Toshiyuki Tanaka, Shiro Ikeda & Takanori Kigawa
- Journal Title
  
  Journal of Biomolecular NMR
  
  Volume: 74 Issue: 2-3 Pages: 125-137
- DOI
  10.1007/s10858-019-00295-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07298
[Journal Article] Design and Progress of Oral Health Examinations in the Tohoku Medical Megabank Project2020
- Author(s)
  Tsuboi, A., et al., Koshiba, S., et al., Yamamoto, M.（合計33名、本研究者は20番目）
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 251 Issue: 2 Pages: 97-115
- DOI
  10.1620/tjem.251.97
- NAID
  130007858973
- ISSN
  0040-8727, 1349-3329
- URL
  https://pure.teikyo.jp/en/publications/62d8f028-92aa-4584-9ae4-a57a88ed1675
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-18K11420, KAKENHI-PROJECT-18K17107, KAKENHI-PROJECT-19H03701, KAKENHI-PROJECT-18H02940
[Journal Article] ドーピング分析の最前線日本アンチ・ドーピング研究コンソーシアムの挑戦2019
- Author(s)
  小柴生造，山本雅之
- Journal Title
  
  体育の化学
  
  Volume: 69 Pages: 504-509
- Data Source
  KAKENHI-PROJECT-17K07298
[Journal Article] Biallelic GALM pathogenic variants cause a novel type of galactosemia2019
- Author(s)
  Wada, Y.,（途中略）,Koshiba, S., （途中略）, Kure, S.（合計２４名、本研究者は２２番目）
- Journal Title
  
  Genet. Med.
  
  Volume: 印刷中 Issue: 6 Pages: 1286-1294
- DOI
  10.1038/s41436-018-0340-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07298
[Journal Article] 3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome2019
- Author(s)
  Tadaka S. et al. Koshiba S. et al. Kinoshita K.（合計２５名、本研究者は１４番目）
- Journal Title
  
  Hum Genome Var
  
  Volume: 6 Issue: 1 Pages: 28-28
- DOI
  10.1038/s41439-019-0059-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-18K10099, KAKENHI-PUBLICLY-19H05200
[Journal Article] Estimating carrier frequencies of newborn screening disorders using a whole-genome reference panel of 3552 Japanese individuals2019
- Author(s)
  Yamaguchi-Kabata, Y.,（途中略）,Koshiba, S., （途中略）, Tohoku Medical Megabank Project Study Group.（合計１9名、本研究者は５番目）
- Journal Title
  
  Hum. Genet.
  
  Volume: 印刷中 Issue: 4 Pages: 389-409
- DOI
  10.1007/s00439-019-01998-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-18K11545, KAKENHI-PROJECT-16K00385, KAKENHI-PROJECT-16K08638, KAKENHI-PUBLICLY-19H05200, KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-16KK0195
[Journal Article] Metabolomic changes in the mouse retina after optic nerve injury.2018
- Author(s)
  Sato K, Saigusa D, Saito R, Fujioka A, Nakagawa Y, Nishiguchi KM, Kokubun T, Motoike IN, Maruyama K, Omodaka K, Shiga Y, Uruno A, Koshiba S, Yamamoto M, Nakazawa T.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 11930-11930
- DOI
  10.1038/s41598-018-30464-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-17K08233, KAKENHI-PROJECT-17K11475, KAKENHI-PROJECT-17K16958
[Journal Article] Genome analyses for the Tohoku Medical Megabank Project towards establishment of personalized healthcare2018
- Author(s)
  Yasuda Jun、Kinoshita Kengo、et al.,
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 165 Issue: 2 Pages: 139-158
- DOI
  10.1093/jb/mvy096
- NAID
  40021809939
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07193, KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-18K11420, KAKENHI-PROJECT-18K11545, KAKENHI-PROJECT-15K00295, KAKENHI-PROJECT-15K08539, KAKENHI-PROJECT-15K09464, KAKENHI-PROJECT-16K00385, KAKENHI-PROJECT-16K08638, KAKENHI-PROJECT-18H02940
[Journal Article] The Tohoku Medical Megabank Project: Design and Mission2016
- Author(s)
  Kuriyama S, Yaegashi N, et al. (Tamiya G; 11th in 58 authors)
- Journal Title
  
  Journal of Epidemiology
  
  Volume: 26 Issue: 9 Pages: 493-511
- DOI
  10.2188/jea.JE20150268
- NAID
  130005409018
- ISSN
  0917-5040, 1349-9092
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01528, KAKENHI-PROJECT-26240044, KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-26462472, KAKENHI-PROJECT-15K00295, KAKENHI-PROJECT-15K08539, KAKENHI-PROJECT-15K09464, KAKENHI-PROJECT-16K00385, KAKENHI-PROJECT-16K08638, KAKENHI-PROJECT-26440018
[Journal Article] Stable isotope labeling strategy based on coding theory.2015
- Author(s)
  Kasai T, Koshiba S, Yokoyama J, Kigawa T
- Journal Title
  
  J. Biomol. NMR
  
  Volume: 63 Issue: 2 Pages: 213-221
- DOI
  10.1007/s10858-015-9978-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26440018, KAKENHI-PROJECT-26650027, KAKENHI-PLANNED-25120003
[Journal Article] 核磁気共鳴 (NMR) のライフサイエンス応用の最新動向2012
- Author(s)
  前田秀明, 小柴生造
- Journal Title
  
  電気学会誌
  
  Volume: 132 Pages: 282-285
- NAID
  10030521850
- Data Source
  KAKENHI-PROJECT-24770108
[Journal Article] Solutionstructure and siRNA-mediated knockdown analysis of the mitochondorial disease-related protein C12orf652012
- Author(s)
  Kogure H, Hikawa Y, Hagihara M, Tochio N, Koshiba S, Inoue Y, Guntert P, Kigawa, T, Yokoyama S, and Nameki N
- Journal Title
  
  Proteins
  
  Volume: 80 Issue: 11 Pages: 2629-2642
- DOI
  10.1002/prot.24152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590354, KAKENHI-PROJECT-23570205, KAKENHI-PROJECT-24770108
[Patent] 腎機能維持又は改善剤2019
- Inventor(s)
  阿部倫明,小柴生造,西岡浩一郎,川口和彦,山崎里美,寺中康行
- Industrial Property Rights Holder
  阿部倫明,小柴生造,西岡浩一郎,川口和彦,山崎里美,寺中康行
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16K08487
[Patent] アルカリ性化剤による血液浄化2018
- Inventor(s)
  阿部倫明,小柴生造,西岡浩一郎,川口和彦,山崎里美,寺中康行
- Industrial Property Rights Holder
  阿部倫明,小柴生造,西岡浩一郎,川口和彦,山崎里美,寺中康行
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K08487
[Patent] 尿細管機能維持又は改善剤2018
- Inventor(s)
  伊藤貞嘉,阿部,小柴,西岡,川口,山崎,寺中康行
- Industrial Property Rights Holder
  伊藤貞嘉,阿部,小柴,西岡,川口,山崎,寺中康行
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16K08487
[Patent] アルカリ性化剤による血液浄化2017
- Inventor(s)
  阿部倫明,小柴生造,西岡浩一郎,川口和彦,山崎里美,寺中康行
- Industrial Property Rights Holder
  阿部倫明,小柴生造,西岡浩一郎,川口和彦,山崎里美,寺中康行
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K08487
[Patent] 経口アルカリ性化剤による尿毒症物質の薬物的血液浄化作用の実現化2017
- Inventor(s)
  阿部倫明，小柴生造，西岡浩一郎，川口和彦，山崎里美，寺中康行
- Industrial Property Rights Holder
  阿部倫明，小柴生造，西岡浩一郎，川口和彦，山崎里美，寺中康行
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-075610
- Filing Date
  2017-04-05
- Data Source
  KAKENHI-PROJECT-16K08487
[Presentation] 遺伝・生活習慣が日本人の血中代謝プロファイルに与える影響の解析2022
- Author(s)
  小柴生造、元池育子、井上仁、菱沼英史、青木裕一、櫻井美由紀、佐藤允治、七谷圭、田高周、城田松之、木下賢吾、山本雅之.
- Organizer
  第９５回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] 東北メディカル・メガバンク計画におけるメタボローム解析2021
- Author(s)
  小柴生造
- Organizer
  第３１回日本疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] 東北大学の最新クライオ電子顕微鏡の活用と共同利用について2021
- Author(s)
  小柴生造、木下賢吾、山本雅之
- Organizer
  第59回日本生物物理学会大会
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] Metabolic phenotyping of individuals in baseline and repeat surveys of Tohoku Medical Megabank Cohort Project2019
- Author(s)
  Koshiba S., Saigusa D., Motoike I., Inoue, J., Shirota M., Aoki Y., Tadaka S., Kinoshita K., Yamamoto M
- Organizer
  Metabolomics 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] コホート調査における代謝プロファイルの経時変化の解析2019
- Author(s)
  小柴生造，元池育子，三枝大輔，井上仁，菱沼英史，青木裕一，田高周，城田松之，木下賢吾，山本雅之
- Organizer
  第92回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] Oral alkali supplementation to reduce uremic toxin in early stage CKD patients.2018
- Author(s)
  Michiaki Abe, Daisuke Saigusa, Seizo Koshiba, Fumitoshi Satoh, Hiroshi Sato, Tadashi Ishii, Sadayoshi Ito and CKOALA study group.
- Organizer
  ISN Frontiers Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08487
[Presentation] Metabolic phenotyping in the population based cohort studies of Tohoku Medical Megabank Project2018
- Author(s)
  Seizo Koshiba, Daisuke Saigusa, Ikuko Motoike, Jin Inoue, Matsuyuki Shirota, Yuichi Aoki, Shu Tadaka, Kengo Kinoshita, Masayuki Yamamoto
- Organizer
  Metabolomics 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] Oral alkali supplementation to reduce uremic toxin in early stage CKD patients2018
- Author(s)
  Abe M, Saigusa D, Koshiba S, Tanabe O, Satoh F, Sato H, Ishii T, Ito S and CKOALA study group
- Organizer
  ISN Frontiers meetings
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08487
[Presentation] Multi Omics Research Project in Tohoku Medical Megabank Organizatio2018
- Author(s)
  S. Koshiba, I. Motoike, D. Saigusa, J. Inoue, M. Shirota, Y. Aoki, S. Tadaka, S. Tomo, K. Kinoshita, M. Yamamoto
- Organizer
  日本質量分析学会・日本プロテオーム学会　２０１８合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] メタボロームGWASによる日本人の代謝プロファイルの解析2018
- Author(s)
  小柴生造，元池育子，三枝大輔，井上仁，青木裕一, 田高周, 城田松之，木下賢吾，山本雅之
- Organizer
  第９１回　日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] Structural and functional analyses of oxidative stress response by Keap1-Nrf2 system2018
- Author(s)
  Seizo Koshiba, Tatsuro Iso, Jin Inoue, Aki Muramatsu, Takafumi Suzuki, Takanori Kigawa, and Masayuki Yamamoto
- Organizer
  ICMRBS 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] ゲノム情報と連携した日本人多層オミックス参照パネルの意義2018
- Author(s)
  小柴生造，元池育子，三枝大輔，井上仁，城田松之，青木裕一，田高周，斎藤智，木下賢吾，山本雅之
- Organizer
  第61回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] 東北メディカル・メガバンク機構のオミックス解析2017
- Author(s)
  小柴生造
- Organizer
  第11回メタボロームシンポジウム
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] コホート研究におけるオミックス解析2017
- Author(s)
  小柴生造
- Organizer
  日本人類遺伝学会（招待講演）
- Invited
- Data Source
  KAKENHI-PROJECT-26440018
[Presentation] 高精度日本人多層オミックス参照パネルの提供2017
- Author(s)
  小柴生造
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-26440018
[Presentation] 東北メディカル・メガバンク機構のオミックス解析2017
- Author(s)
  小柴生造
- Organizer
  第11回メタボロームシンポジウム
- Data Source
  KAKENHI-PROJECT-26440018
[Presentation] 経口アルカリ性化剤により薬物的血液浄化される尿毒症物質の検討2017
- Author(s)
  阿部倫明，三枝大輔，小柴生造，鈴木洋一，田邊修，安田純，佐藤文俊，工藤正孝，佐藤博，森本玲，中道崇，小川晋，清元秀泰，三木俊，高山真，宮崎真理子，石井正，伊藤貞嘉，CKOALA 研究グループ
- Organizer
  第60回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-16K08487
[Presentation] コホート研究におけるオミックス解析2017
- Author(s)
  小柴生造
- Organizer
  日本人類遺伝学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] Metabolomics Approach in Tohoku Medical Megabank Project Prospective Cohort Studies2017
- Author(s)
  Seizo Koshiba, Daisuke Saigusa, Ikuko Motoike, Natsuyuki Shirota, Jun Yasuda, Kenga Kinoshita, Masayuki Yamamoto
- Organizer
  Metabolomics 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440018
[Presentation] メタボローム解析による血液検体保管条件の検討2017
- Author(s)
  井上仁, 三枝大輔, 工藤久智, 峯岸直子, 小柴生造, 山本雅之.
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-26440018
[Presentation] 経口アルカリ性化剤により薬物的血液浄化される尿毒症物質の検討2017
- Author(s)
  阿部倫明,三枝大輔,小柴生造,鈴木洋一,田邊修,安田純,佐藤文俊,工藤正孝,佐藤博,森本玲,中道崇,小川晋,清元秀泰,三木俊,高山真,宮崎真理子,石井正,伊藤貞嘉,CKOALA 研究グループ
- Organizer
  第60回日本腎臓学会学術総会
- Place of Presentation
  仙台，仙台国際センター
- Year and Date
  2017-05-26
- Data Source
  KAKENHI-PROJECT-16K08487
[Presentation] 酸化ストレス応答におけるKeap1の構造・相互作用解析2017
- Author(s)
  井上仁, 村松亜紀, 鈴木隆史, 磯達朗, 小柴生造, 山本雅之
- Organizer
  第56回NMR討論会
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] 高精度日本人多層オミックス参照パネルの提供2017
- Author(s)
  小柴生造
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] メタボローム解析による血液検体保管条件の検討2017
- Author(s)
  井上仁, 三枝大輔, 工藤久智, 峯岸直子, 小柴生造, 山本雅之.
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] 酸化ストレス応答におけるKeap1の構造・相互作用解析2017
- Author(s)
  井上仁, 村松亜紀, 鈴木隆史, 磯達朗, 小柴生造, 山本雅之
- Organizer
  第56回NMR討論会
- Data Source
  KAKENHI-PROJECT-26440018
[Presentation] Metabolomics Approach in Tohoku Medical Megabank Project Prospective Cohort Studies.2017
- Author(s)
  Seizo Koshiba, Daisuke Saigusa, Ikuko Motoike, Natsuyuki Shirota, Jun Yasuda, Kenga Kinoshita, Masayuki Yamamoto.
- Organizer
  Metabolomics 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07298
[Presentation] Protein 19F Labeling Strategy for In-Cell NMR and Functional Analyses.2016
- Author(s)
  Koshiba S., Watanabe S., Ikari M., Matsuda N., Iso T., Suzuki, T. Yamamoto M., and Kigawa T.
- Organizer
  International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2016)
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440018
[Presentation] 19F標識技術を利用したKeap1-Nrf2タンパク質の構造機能解析2016
- Author(s)
  小柴生造，渡部暁，碇正臣，松田夏子，磯達郎，鈴木隆史，木川隆則，山本雅之
- Organizer
  第39回日本分子生物学会大会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26440018
[Presentation] 日本人多層オミックス参照パネルの拡張2016
- Author(s)
  小柴生造, 三枝大輔，元池育子，小島要，城田松之，齊藤智，勝岡史城，河合洋介，山口由美，田邉修，長﨑正郎，安田純，木下賢吾，山本雅之
- Organizer
  第８９回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26440018
[Presentation] Selective Isotope labeling methodology for structure determination of large-molecular-weight protein using th e cell-free protein synthesis system: application to 45 kDa human vaccinia related kinase 1 (VRK1)2012
- Author(s)
  Koshiba S., Tochio N., Yokoyama J., Yoon H., and Kigawa T.
- Organizer
  ICMRBS
- Place of Presentation
  Lyon (France)
- Data Source
  KAKENHI-PROJECT-24770108
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1. 寳澤篤 (00432302)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Kogure Mana (30789764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Abe Michiaki (40400246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. Anzai Toshihisa (60232089)

# of Collaborated Projects: 1 results

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5. Ishida Takanori (00292318)

# of Collaborated Projects: 1 results

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6. 瀧靖之 (10375115)

# of Collaborated Projects: 1 results

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7. 三枝大輔 (90545237)

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# of Collaborated Products: 5 results
8. 永井利幸 (00528218)

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9. 小川貴弘 (20524028)

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10. 横田勲 (20761414)

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11. 清水厚志 (30327655)

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12. 平田健司 (30431365)

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13. 櫻井美佳 (80508359)

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14. 布施昇男 (10302134)

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16. 栗山進一 (90361071)

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18. 工藤大介 (30455844)

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19. 田宮元 (10317745)

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20. 早川峰司 (10374282)

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21. 菱沼英史 (10824609)

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22. 久志本成樹 (50195434)

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23. 成田暁 (50459468)

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24. 山川一馬 (50597507)

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25. 佐藤哲哉 (50830197)

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26. 湯本哲也 (80535790)

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27. 後藤匡啓 (80622894)

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28. 近藤豊 (90642091)

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29. 石原唯史 (70648295)

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30. 佐藤幸男 (00445272)

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31. 錦見満曉 (00816118)

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32. 堤悠介 (50627320)

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33. 高山渉 (50825502)

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34. 鈴木浩大 (80724583)

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35. 春日井大介 (60844909)

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36. Shoji Mutsumi

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37. SUZUKI Takafumi

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38. TAGUCHI Keiko

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39. 宇留野晃

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40. 安田純

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41. 山本雅之

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42. 坂井舞

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44. 小林朋子

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45. 井上裕介

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46. 行木信一

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KOSHIBA Seizo 小柴 生造

Research Projects

Research Products

Co-Researchers

Study regarding metabolomics of participants with higher genetic risk of life-style related diseases

Principal Investigator

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Identifying Novel Sepsis Endotypes

Principal Investigator

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Interdisciplinary fusion research for precision medicine in heart failure patients with preserved ejection fraction

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Review Section

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Integrated analysis of genetic polymorphisms, lifestyle and plasma metabolomics for breast cancer morbidity risk reduction

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Review Section

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Effects of Diet and Nutrients on Cognitive Indices and Brain Morphology: An Examination Using Omics Analysis

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Structural analysis of in vivo protein-ligand interactions by 19F-NMR and PREPrincipal Investigator

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Reno-protective mechanism by therapeutic intervention of metabolic acidosis on chronic kidney disease

Principal Investigator

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Protein 19F Labeling Strategy for In-Cell NMR and Functional AnalysesPrincipal Investigator

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Dynamic behavior of human VRK1 kinase in living cellsPrincipal Investigator

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[Book] 最新医学 74巻2号 特集 バイオインフォマティクスの進展・臨床応用2019

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Total Pages

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[Book] 遺伝子医学MOOK(32) 難病研究up-to-date2017

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Total Pages

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[Book] 遺伝子医学MOOK(32) 難病研究up-to-date2017

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Total Pages

Publisher

ISBN

Data Source

[Journal Article] Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut22023

Author(s)

Journal Title

DOI

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KOSHIBA Seizo 小柴生造

[Book] 最新医学 74巻2号特集　バイオインフォマティクスの進展・臨床応用2019

[Book] 遺伝子医学MOOK(32)　難病研究up-to-date2017

[Book] 遺伝子医学MOOK(32)　難病研究up-to-date2017